PHARMAKINETICS LABORATORIES INC
SC 13D/A, 1997-12-15
TESTING LABORATORIES
Previous: DAWSON GEOPHYSICAL CO, 10-K405, 1997-12-15
Next: PHARMAKINETICS LABORATORIES INC, SC 13D/A, 1997-12-15





                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                (Amendment No. 1)

                        PharmaKinetics Laboratories, Inc.
- --------------------------------------------------------------------------------

                                (Name of Issuer)

                    Common Stock, Par Value $0.001 Per Share

- --------------------------------------------------------------------------------

                         (Title of Class of Securities)

                                   717131 10 6
                          -----------------------------

                                 (CUSIP Number)

                                Leslie B. Daniels
                               CAI Advisors & Co.
                           767 Fifth Avenue, 5th Floor
                               New York, NY 10153
                                 (212) 319-2525
- --------------------------------------------------------------------------------

(Name, Address and Telephone Number of Persons Authorized to Receive Notices 
                              and Communications)

                                December 4, 1997
                          ----------------------------

             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with this statement.| | (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be 
sent.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                                                         1

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         CAI Advisors & Co.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a) X
                                                                (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           WC
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                             |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
           Quebec, Canada
                                                           7 SOLE VOTING POWER
                                                             11,666,400
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      11,666,400**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         11,666,400**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                 |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         43.6%**
     14  TYPE OF REPORTING PERSON*
         PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         2

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aster-Cephac S.A.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a) X
                                                                  (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          WC
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                               |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         France
                                                           7 SOLE VOTING POWER
                                                             2,916,600
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      2,916,600**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,916,600**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                  |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         10.9%**
     14  TYPE OF REPORTING PERSON*
         CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         3

<PAGE>




Item 1.  Security and Issuer.

         This Statement  relates to 14,583,000  shares of the common stock,  par
value $0.001 per share (the "Common  Stock"),  of  PharmaKinetics  Laboratories,
Inc., a Maryland corporation (the "Company").  The Company's principal executive
offices are located at 302 West Fayette Street, Baltimore, Maryland 21201.

Item 2. Identity and Background.

     CAI Advisors & Co. ("CAI") and Aster-Cephac S.A. ("Aster")  (together,  the
"Reporting Persons") filed the Schedule 13D (the "Schedule 13D") amended by this
Amendment No. 1 to Schedule 13D on November 13, 1997. The  information  required
by Item 2 is included in the Schedule 13D.

Item 3. Source and Amount of Funds or Other Consideration.

         The source of funds used to purchase  the  securities  will  consist of
working capital of the Reporting Persons. The aggregate amount of funds required
to purchase the Shares and Warrants (as those terms are defined in Item 4) is $5
million. The aggregate exercise price of the Warrants is $7.5 million.

Item 4. Purpose of Transaction.

         The  purpose of the  acquisition  of  securities  of the Company by the
Reporting  Persons is for investment  and to facilitate a strategic  partnership
between  Aster and the  Company.  Except as  discussed  in this Item 4,  neither
Reporting  Person  currently  has any plan or proposal that relates to, or would
result  in,  any of the  actions  enumerated  in Item 4 of the  instructions  to
Schedule 13D.

         On December 4, 1997,  CAI,  Aster,  which is controlled by CAI, and the
Company  entered into a Preferred  Share and Warrant  Purchase  Agreement  (such
agreement,  along with the schedules thereto, the "Purchase Agreement") pursuant
to which CAI and Aster have agreed to purchase an aggregate of 833,300 shares of
the Company's  Class A Convertible  Preferred Stock  convertible  into 8,333,000
shares of Common Stock (the  "Shares")  and warrants to purchase an aggregate of
6,250,000  shares of Common  Stock at an exercise  price of $1.20 per share (the
"Warrants").  Under the Purchase Agreement, CAI is obligated to purchase 666,640
Shares and Warrants to purchase  5,000,000  shares of Common Stock, and Aster is
obligated to purchase  166,660 Shares and Warrants to purchase  1,250,000 shares
of Common Stock. The Purchase  Agreement  provides that CAI and Aster may assign
their rights to purchase  the Shares and  Warrants to certain  parties with whom
they are affiliated,  as well as to certain unaffiliated  parties. The Reporting
Persons  will file an  additional  amendment  to the Schedule 13D to reflect the
assignment of such rights.

         The Purchase  Agreement  provides that the Shares may be converted into
Common  Stock at any time at the option of the holders and that  holders will be
entitled to vote on all matters submitted to a vote of the holders of the Common
Stock and will be entitled to that number of votes equal to the number of shares
of Common Stock into which their Shares could be converted. In addition, so long
as the Conversion Shares (as hereinafter defined) constitute at least 10% of the
Total Shares Outstanding (as hereinafter defined), holders of the Shares, voting
as a separate  class,  will have the right to elect that number of  Directors to
the Board of  Directors  of the Company  that bears the same  proportion  to the
total

                                                         4

<PAGE>



number of  directors  on the Board as the  Conversion  Shares  bear to the Total
Shares Outstanding.  So long as the Conversion Shares constitute at least 35% of
the Total Shares  Outstanding,  the holders of the Shares will have the right to
elect at least 50% of the Board members.  "Conversion  Shares" is defined as the
number of shares of Common Stock into which the Shares  could be converted  plus
the number of shares of Common Stock owned by CAI, Aster,  their  affiliates and
certain   assignees,   regardless  of  how  or  when  acquired.   "Total  Shares
Outstanding"  is defined as the Company's  outstanding  Common  Stock,  plus the
number of shares of Common  Stock  into  which the  Shares  could be  converted.
Holders  of the  Shares  also  will have  certain  anti-dilution,  dividend  and
liquidation  rights. For a complete  description of the terms of the Shares, see
Schedule 1.1B to the Purchase Agreement, "Description and Designation of Class A
Convertible Preferred Stock," filed as an exhibit to this Amendment No. 1.

         The  Purchase  Agreement  provides  that the  Warrants  will not be not
exercisable  until the Company files an amendment to its charter  increasing the
number of shares of Common Stock that it is authorized to issue. Thereafter, the
Warrants will be exercisable  at any time for a period of three years  following
the sale of the Shares and Warrants.  For a complete description of the terms of
the Warrants,  see Schedule 1.1C to the Purchase  Agreement,  "Form of Warrant,"
filed as an exhibit to this Amendment No. 1.

         In addition, the Purchase Agreement provides that in the event that (i)
the Company has not by April 30, 1998 filed an amended  charter  increasing  the
number of shares that it is  authorized  to issue and  reserved  such shares for
issuance upon exercise of the Warrants,  or (ii) the Company fails to consummate
the sale of the Shares or the  Warrants by December 31, 1997 (or such later date
as may be unanimously agreed by the parties to the Purchase Agreement), then the
Warrants   will  be  cancelled   and  the  Company   will,   for  no  additional
consideration, issue to CAI and Aster (or their assigns) warrants to purchase an
aggregate of 2,750,000  shares of Common Stock at an exercise  price of $.60 per
share and  otherwise  having terms  substantially  identical to the terms of the
Warrants.  The  Purchase  Agreement  further  provides  that  the  Common  Stock
underlying the Shares and the Warrants will have certain registration rights and
that the Company will enter into a technology  sharing agreement with Aster. See
Schedules 5.2 and 5.3 to the Purchase  Agreement,  "Form of Registration  Rights
Agreement" and "Form of Technology Sharing Agreement," filed as exhibits to this
Amendment No. 1.

Item 5. Interest in Securities of the Company.

         In  accordance  with Rules  13d-3(d)(1)(i)  and  13d-5(b)(1)  under the
Securities  Act of 1933,  as  amended,  the  Reporting  Persons may be deemed to
beneficially  own  an  aggregate  of  14,583,000  shares  of  Common  Stock,  or
approximately  54.5% of the Company's  outstanding  Common Stock.  The Reporting
Persons  will have the right to acquire  8,333,000  shares of Common  Stock,  or
approximately 31.1% of the Company's  outstanding Common Stock, based upon their
ownership  of the Shares,  and the right to acquire  6,250,000  shares of Common
Stock,  or 23.4% of the Company's  outstanding  Common  Stock,  based upon their
ownership of the Warrants.  CAI will have sole voting and dispositive power with
respect to 11,666,400  shares of Common  Stock,  or  approximately  43.6% of the
Company's  outstanding  Common  Stock,  and  Aster  will have  sole  voting  and
dispositive  power with  respect  to the  remaining  2,916,600  shares of Common
Stock, or approximately 10.9% of the Company's outstanding Common Stock.

         Neither Reporting Person nor any partner, executive officer or director
of either Reporting  Person,  to the knowledge of either Reporting  Person,  had
purchased any of the Company's securities during the past sixty days.

                                                         5

<PAGE>




Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
Securities of the Company.

         None except as disclosed in Item 4.

Item 7. Material to be Filed as Exhibits.

        The Purchase Agreement and certain schedules thereto are filed as 
exhibits to this Amendment No. 1.



                                   SIGNATURES

         After  reasonable  inquiry and to the best of his knowledge and belief,
each of the  undersigned  certifies  that  the  information  set  forth  in this
Statement is true, complete and correct.


Date: December 15, 1997


                                                     CAI ADVISORS & CO.


                                                     By: /s/ LESLIE B. DANIELS
                                                              Leslie B. Daniels
                                                              Partner


                                                     ASTER-CEPHAC S.A.


                                                     By:  /s/ LESLIE B. DANIELS
                                                              Leslie B. Daniels
                                                              Director


                                                         6













                 PREFERRED SHARE AND WARRANT PURCHASE AGREEMENT

                                  BY AND AMONG

                       PHARMAKINETICS LABORATORIES, INC.,

                               CAI ADVISORS & CO.

                                       AND

                               ASTERo CEPHAC S.A.










                                DECEMBER 4, 1997



                                      - i -

<PAGE>



                                TABLE OF CONTENTS

                                                                       Page

Section 1  PURCHASE AND SALE OF SHARES AND WARRANTS.....................1
           1.1      Purchase and Sale of Shares and Warrants............1
           1.2      Purchase Price......................................2
           1.3      Delivery of Certificates and Payment................2
           1.4      The Closing.........................................2

Section 2  REPRESENTATIONS AND WARRANTIES OF THE COMPANY................2
           2.1      Organization and Standing of the Company............2
           2.2      Corporate Action....................................2
           2.3      Compliance with Certain Instruments.................3
           2.4      Validity of Shares and Conversion Shares............3
           2.5      Capitalization; Status of Capital Stock.............3
           2.6      Governmental Approvals..............................4
           2.7      Securities Laws.....................................4
           2.8      Financial Information...............................4
           2.9      Litigation..........................................4
           2.10     Compliance with Law.................................4
           2.11     Good Laboratory and Clinical Practices..............5
           2.12     Licenses and Permits................................5
           2.13     Certain Agreements of Officers and Employees........5
           2.14     Transactions with Affiliates........................6
           2.15     Assumptions or Guaranties of Indebtedness...........6
           2.16     Investments.........................................6
           2.17     Title to Assets.....................................6
           2.18     Material Contracts..................................7
           2.19     ERISA...............................................8
           2.20     Insurance...........................................8
           2.21     Registration Rights.................................8
           2.22     Absence of Certain Developments.....................8
           2.23     Books and Records...................................9
           2.24     Disclosure..........................................9
           2.25     Brokers or Finders.................................10

Section 3  REPRESENTATIONS AND WARRANTIES OF PURCHASERS................10
           3.1      Investment Representations.........................10
           3.2      Access to Information..............................10
           3.3      Sophistication and Knowledge.......................10
           3.4      Power..............................................10

Section 4  COVENANTS...................................................11
           4.1      Use of Proceeds....................................11
           4.2      Best Efforts Cooperation...........................11

                                     - ii -

<PAGE>



           4.3      General Covenants..................................11
           4.4      Public Announcements...............................12
           4.5      Confidentiality....................................12
           4.6.     Charter Amendments.................................12
           4.7      Sales and Use Taxes................................12
           4.8      Validity of Warrants...............................12

Section 5  CONDITIONS PRECEDENT TO PURCHASERS' OBLIGATIONS TO PURCHASE
           THE SHARES AND THE WARRANTS.................................13
           5.1      Representations and Warranties.....................13
           5.2      Technology Sharing Agreement.......................13
           5.3      Registration Rights Agreement......................13
           5.4      Articles Supplementary.............................13
           5.5      Documentation at Closing...........................13
           5.6      No Actions or Proceedings..........................13
           5.7      Business Combination Act Opt-out...................14

Section 6  CONDITIONS PRECEDENT TO COMPANY'S OBLIGATIONS TO SELL THE
           SHARES AND THE WARRANTS.....................................14
           6.1      Representations and Warranties.....................14
           6.2      Technology Sharing Agreement.......................14
           6.3      Documentation at Closing...........................14
           6.4      No Actions or Proceedings..........................14

Section 7  CONTINGENT WARRANTS.........................................14
           7.1      Contingent Warrants................................14
           7.2      Opinion of Counsel.................................15
           7.3      Cancellation of Warrants...........................15

Section 8  MISCELLANEOUS...............................................15
           8.1      Survival of Representations and Warranties.........15
           8.2      Expenses...........................................15
           8.3      Notices............................................15
           8.4      Modification or Waiver.............................16
           8.5      Binding Effect and Assignment......................17
           8.6      Governing Law......................................17
           8.7      Section Headings...................................17
           8.8      Further Assurances.................................17
           8.9      Entire Agreement...................................17
           8.10     No Third Party Beneficiaries.......................17
           8.11     Counterparts.......................................17
           8.12     Severability.......................................17
           8.13     Termination........................................18





                                     - iii -

<PAGE>



                                    SCHEDULES

Schedule 1.1A     Purchasers

Schedule 1.1B     Description and Designation of Class A Convertible 
                  Preferred Stock

Schedule 1.1C     Form of Warrants

Schedule 2.3      Compliance with Certain Instruments

Schedule 2.5      Agreements Concerning Capital Stock

Schedule 2.9      Litigation

Schedule 2.10     Hazardous Materials

Schedule 2.12     Permits

Schedule 2.13     Agreements with Officers and Employees

Schedule 2.14     Transactions with Affiliates

Schedule 2.16     Investments

Schedule 2.17     Title to Assets

Schedule 2.18     Material Contracts

Schedule 2.19     ERISA

Schedule 2.22     Certain Developments

Schedule 5.2      Form of Technology Sharing Agreement

Schedule 5.3      Form of Registration Rights Agreement

Schedule 5.5(a)   Form of Opinion of Ober, Kaler, Grimes & Shriver



                                     - iv -

<PAGE>



                 PREFERRED SHARE AND WARRANT PURCHASE AGREEMENT

         THIS PREFERRED SHARE AND WARRANT PURCHASE AGREEMENT is made and entered
into on this 4th day of DECEMBER 1997, by and among PHARMAKINETICS LABORATORIES,
INC.  a  corporation  organized  under  the laws of the state of  Maryland  (the
"Company"),  CAI  ADVISORS  & CO.,  a  partnership  organized  under the laws of
Quebec,  Canada ("CAI"),  and ASTERo CEPHAC S.A., a company  organized under the
laws  of  France  ("Aster")  (CAI  and  Aster,  each  referred  to  herein  as a
"Purchaser" and together as the "Purchasers").

                                    RECITALS

         A. The  Company  desires to issue and sell to the  Purchasers,  and the
Purchasers  desire to purchase from the Company,  an aggregate of 833,300 shares
(the  "Shares")  of the  Company's  authorized  but  unissued  shares of Class A
Convertible Preferred Stock (the "Preferred Stock"),  initially convertible into
8,333,000  shares of the Company's  Common Stock, par value $.001 per share (the
"Common Stock").

         B. The  Company  desires to issue and sell to the  Purchasers,  and the
Purchasers  desire  to  purchase  from the  Company,  warrants  to  purchase  an
aggregate of 6,250,000 shares of the Company's Common Stock at an exercise price
of $1.20 per share and with a term of three years (the "Warrants").

         NOW, THEREFORE,  in consideration of the  representations,  warranties,
conditions,  and agreements  hereinafter set forth,  the parties hereto agree as
follows:

Section 1         PURCHASE AND SALE OF SHARES AND WARRANTS.

         1.1 Purchase  and Sale of Shares and  Warrants.  The Company  agrees to
issue and sell to the Purchasers at the Closing (as hereinafter defined) and the
Purchasers  agree to purchase,  severally  but not  jointly,  the Shares and the
Warrants, in the quantities set forth opposite each Purchaser's name in Schedule
1.1A.  The terms of the  Shares  and the form of the  Warrants  are set forth in
Schedules  1.1B and 1.1C,  respectively.  The Company  shall not be obligated to
issue and sell any of the Shares and the  Warrants  unless all of the Shares and
Warrants are purchased.

         The  Purchasers may assign their rights to purchase all or a portion of
the  Shares  and  Warrants  to one or more  Affiliates  (as  defined  below)  or
unaffiliated third parties; provided,  however, that any such assignees shall be
accredited  investors  as defined in  Regulation D under the  Securities  Act of
1933, as amended (the "Securities  Act"), and shall make  representations to the
Company  identical to the  representations  made by the Purchasers in Section 3;
and provided,  further,  that the Purchasers  must obtain the written consent of
the Company prior to assigning their rights to any  unaffiliated  third parties,
which  consent  shall  not be  unreasonably  withheld.  Prior to any  assignment
hereunder,  the Purchasers shall identify and provide such information regarding
each assignee as the Company may  reasonably  request for purposes of confirming
that the assignee is an  accredited  investor and of complying  with  applicable
federal  and  state   securities   laws.  For  purposes  of  this  Section  1.1,
"Affiliates" means any person that,

                                                         1

<PAGE>



directly  or  indirectly,  through  one or  more  intermediaries,  controls,  is
controlled by, or is under common control with either  Purchaser,  or any person
that is a partner of either Purchaser in any general or limited partnership.

         1.2 Purchase Price. The aggregate purchase price for the Shares and the
Warrants shall be $5,000,000 (the "Aggregate  Purchase  Price") payable in cash,
of which  $4,937,500 shall be allocated as the purchase price for the Shares and
$62,500 shall be allocated as the purchase price for the Warrants.

         1.3  Delivery  of  Certificates   and  Payment.   At  the  Closing  (as
hereinafter  defined),  the Company  shall  issue and deliver to the  Purchasers
certificates  representing the Shares and Warrants, and the Purchasers shall pay
the Aggregate Purchase Price by means of a wire transfer of funds to the account
of the Company.

         1.4 The Closing. The closing of the purchase and sale of the Shares and
the Warrants shall take place by telephone conference call on December 19, 1997,
or by such other means or such other date as the  Purchasers and the Company may
unanimously agree (the "Closing").

Section 2          REPRESENTATIONS AND WARRANTIES OF THE COMPANY.

         The Company hereby  represents and warrants to each Purchaser as of the
Closing as follows:

         2.1  Organization  and Standing of the  Company.  The Company is a duly
organized and validly  existing  corporation  in good standing under the laws of
the State of Maryland and is duly  qualified  and in good  standing as a foreign
corporation authorized to do business in all jurisdictions wherein the character
of the property owned or leased or the nature of the activities  conducted by it
makes such qualification necessary,  except where the failure to be so qualified
would  not  have a  material  adverse  effect  on the  business,  operations  or
financial condition of the Company.  The Company has no subsidiaries with active
business operations.

         2.2 Corporate Action. This Agreement,  the Technology Sharing Agreement
set forth as Schedule 5.2, and the  Registration  Rights  Agreement set forth as
Schedule 5.3 (the  Technology  Sharing  Agreement  and the  Registration  Rights
Agreement, along with the Warrants, being collectively herein referred to as the
"Ancillary  Agreements"),  and all of the transactions  contemplated  hereby and
thereby have been duly authorized by all required  corporate  action,  and as of
the Closing will be duly executed and  delivered,  and each will  constitute the
legal,  valid and binding  obligations of the Company,  enforceable  against the
Company in accordance with their  respective  terms. As of the date hereof,  the
Company has not  obtained  the  stockholder  approval  required to increase  the
number of shares of Common  Stock  that the  Company is  authorized  to issue in
order to  reserve a  sufficient  number  of shares of Common  Stock to cover the
shares of Common Stock issuable upon exercise of the Warrants.


                                                         2

<PAGE>



         2.3 Compliance with Certain  Instruments.  Except as listed on Schedule
2.3, the Company is in  compliance  in all material  respects with the terms and
provisions of its Charter and By-laws,  each as amended and/or restated to date,
and all mortgages,  indentures,  leases, agreements,  judgments, decrees, orders
and  other  instruments  by  which  it is  bound  or to  which  it or any of its
properties  or  assets  are  subject.   Neither  the  execution,   delivery  and
performance of this Agreement or the Ancillary  Agreements nor the  consummation
of any transaction  contemplated hereby or thereby has constituted,  or with the
passage  of time or giving of notice  will  constitute,  a  material  default or
violation  of or conflict  with any term or  provision  of any of the  foregoing
documents, instruments, laws, statutes, rules or regulations.

         2.4 Validity of Shares and Conversion Shares. The Shares and the Common
Stock  issuable  upon  conversion of the Shares and exercise of the Warrants and
the  Contingent  Warrants  (as  defined in Section  7.1) (such  shares of Common
Stock, collectively, the "Conversion Shares") when issued, sold and delivered in
accordance with the terms of this Agreement will be validly  issued,  fully paid
and nonassessable with no personal liability  attaching to the ownership thereof
and will be free and  clear of all  liens,  charges,  restrictions,  claims  and
encumbrances  imposed  by or  through  the  Company,  except  as  set  forth  in
applicable  state and federal  securities  laws.  The Company has  reserved  for
issuance a number of shares  sufficient to enable the  Purchasers to convert the
Shares and to exercise the Contingent Warrants.

         2.5  Capitalization;  Status of Capital Stock. As of November 30, 1997,
the authorized  capital stock of the Company  consisted of (i) 25,000,000 shares
of  Common  Stock,  par value  $.001 per  share,  and (ii)  1,500,000  shares of
Preferred Stock,  without par value, of which 12,195,819  shares of Common Stock
were issued and  outstanding  and  1,670,425  shares  reserved for issuance (not
including  shares  reserved for  issuance in  connection  with the  transactions
contemplated   hereby)  and  no  shares  of  Preferred   Stock  were  issued  or
outstanding.  All the  outstanding  shares of capital  stock of the Company have
been duly authorized, and are validly issued, fully paid and non-assessable.

         With  the  exception  of  the  Shares,  the  Warrants,  the  Contingent
Warrants,  options  to  purchase  1,385,825  shares of Common  Stock  granted to
directors,  officers and other  employees  of the  Company,  options to purchase
284,600 shares of Common Stock granted to the former Chief Executive  Officer of
the Company  and certain  consultants  of the  Company,  and options to purchase
1,591,200  shares of Common Stock authorized but not granted under the Company's
stock option plans, no options, warrants,  subscriptions or rights of any nature
to  acquire  from the  Company,  or  commitments  of the  Company  to issue,  or
securities  convertible  into,  shares of capital stock or other  securities are
authorized,  issued or outstanding. None of the Company's outstanding securities
or authorized capital stock are subject to any rights of redemption, repurchase,
rights of first  refusal,  preemptive  rights or other similar  rights,  whether
contractual,  statutory  or  otherwise,  for the  benefit  of the  Company,  any
stockholder,  or any other  person.  To the Company's  knowledge,  and except as
contemplated  by this  Agreement and as set forth in Schedule 2.5,  there are no
agreements,    understandings,   trusts   or   collaborative   arrangements   or
understandings concerning the voting or transfer of the capital stock of

                                                         3

<PAGE>



the Company. The offer and sale of all capital stock and other securities of the
Company  issued  prior to the  Closing  complied  with or were  exempt  from all
applicable  federal and state  securities laws and no stockholder has a right of
rescission or damages with respect thereto.

         2.6 Governmental  Approvals.  Except for the filing of (i) the Articles
Supplementary  (as defined in Section 5.4), (ii) a charter  amendment  providing
for an increase in the number of authorized  shares of Common  Stock,  (iii) the
approval of the  Maryland  Industrial  Development  Financing  Authority,  which
approval  has been  granted,  and (iv) any  notice  that may be  required  under
applicable state and/or federal  securities laws (which,  if required,  shall be
filed on or before the Closing), no authorization,  consent, approval,  license,
qualification,  exemption  of or  filing  or  registration  with  any  court  or
governmental department,  commission,  board, bureau, agency or instrumentality,
domestic  or  foreign,  is or will  be  necessary  in  connection  with  (i) the
execution  and  delivery  by the  Company  of this  Agreement  or the  Ancillary
Agreements, (ii) the offer, issuance, sale, execution or delivery of the Shares,
the Warrants and the Contingent Warrants, (iii) the issuance, sale, execution or
delivery of the Conversion Shares, or (iv) the performance by the Company of its
obligations under this Agreement or the Ancillary Agreements.

         2.7  Securities  Laws.  The Company has  complied  with all  applicable
federal and state securities  laws,  including the Securities Act, in connection
with  the  offer,  issuance  and  sale  of the  Shares,  the  Warrants,  and the
Contingent Warrants.

         2.8  Financial  Information.  The  financial  statements of the Company
included in the Company's 10-K for the year ended June 30, 1997 and 10-Q for the
three months  ended  September  30, 1997 (the  "Financial  Statements")  present
fairly the financial position and results of operations of the Company as of the
dates and for the periods indicated therein and have been prepared in accordance
with generally accepted accounting principles  consistently  applied.  Except as
set forth or reserved against in the Financial  Statements,  the Company did not
have as of the  date of the  Financial  Statements  any  material  liability  or
obligation of any nature, whether accrued,  absolute,  contingent,  or otherwise
and whether due or to become due.

         2.9  Litigation.  Except as  disclosed  in  Schedule  2.9,  neither the
Company  nor any  director  or officer  of the  Company is subject to any order,
writ, injunction or decree, of any court, commission,  board or other government
agency.  Except as set forth in  Schedule  2.9,  there  are no  actions,  suits,
investigations  or proceedings  pending or threatened (nor does the Company have
any  knowledge  of any basis  therefor)  that could  reasonably  be  expected to
result, either in any case or in the aggregate,  in a material adverse change in
the business,  operations,  affairs or financial  condition of the Company or in
any of its properties or assets,  or which could  reasonably be expected to call
into question the validity of this Agreement,  the Ancillary Agreements,  or any
action contemplated hereby or thereby.


                                                         4

<PAGE>



         2.10  Compliance with Law. The Company is in compliance in all material
respects with all applicable federal,  state, local and foreign laws,  statutes,
rules and regulations,  orders,  judgments,  injunctions,  decrees,  and similar
instruments,  including those relating to the environment or occupational safety
and health.  The Company has no knowledge of any pending  legislation,  rules or
regulations  that  would be  likely  to have a  material  adverse  effect on the
Company's  business  or results  of  operations.  The  Company  has not  caused,
suffered or permitted any hazardous  materials,  oil or other petroleum products
to be generated,  stored, handled, disposed or, released,  spilled or discharged
at, on, from or onto the  Company's  premises,  except as  disclosed on Schedule
2.10.

         2.11  Good  Laboratory  and  Clinical  Practices.  The  Company  is  in
compliance in all material  respects with all "good  laboratory  practices"  and
with all "good clinical  practices," to the extent such practices are applicable
to the Company's  operations,  in accordance  with the provisions of Title 21 of
the Code of Federal Regulations, and the Company is not the object of any notice
of insufficiency or of deficiency or of any notice of material corrective action
to be  taken,  from any  applicable  federal  or state  governmental  agency  or
regulatory body, including the U.S. Food and Drug Administration.

         2.12 Licenses and Permits.  The Company has all local,  state,  federal
and foreign licenses, permits, registrations,  certificates,  accreditations and
approvals (collectively, the "Permits") necessary for the Company to operate and
conduct its business as presently conducted,  and there do not exist any waivers
or  exemptions  relating  thereto.  The Company is in compliance in all material
respects  with,  and  there  exist no  grounds  for  revocation,  suspension  or
limitation of any of, the Permits.  No notices have been received by the Company
with respect to any threatened,  pending, or possible  revocation,  termination,
suspension  or  limitation  of the Permits.  To the  Company's  knowledge,  each
employee  of the Company has all  Permits  required to perform  such  employee's
designated  functions and duties for the Company in connection  with  conducting
the  business  of the Company as  presently  conducted,  and,  to the  Company's
knowledge,  there  exist no  waivers  or  exemptions  relating  thereto.  To the
Company's knowledge, there is no default under, nor does there exist any grounds
for revocation,  suspension or limitation of, any such Permits.  The Permits are
listed on Schedule 2.12.

         2.13     Certain Agreements of Officers and Employees.

         Neither  the Company  nor, to the  Company's  knowledge,  any  officer,
employee, agent,  representative or consultant of the Company is in violation of
any term of any employment or consulting  contract,  confidential or proprietary
information agreement,  noncompetition agreement,  nonsolicitation agreement, or
any similar  contract or agreement or any restrictive  covenant  relating to the
right of any such person to be employed or engaged by the  Company,  whether the
Company  is party to such  agreement  or not.  All of such  agreements,  and all
severance and similar agreements,  to which the Company is a party are listed on
Schedule 2.13 and copies have been provided or made  available to the Purchasers
or their representatives.

                                                         5

<PAGE>



         No officer,  consultant or employee of the Company  whose  termination,
either individually or in the aggregate, could have a material adverse effect on
the Company,  has been  terminated or has terminated his or her employment  with
the Company since January 1, 1997,  and no such officer,  consultant or employee
of the Company has, to the Company's  knowledge,  the  intention of  terminating
such person's employment or engagement with the Company.

         Schedule  2.13  sets  forth  each  officer,  employee,  consultant  and
contractor  of  the  Company  whose  involvement,   either  individually  or  in
conjunction with others, in the design or development of property or information
proprietary to the Company,  in the past two years has been, or in the future is
expected to be, material to the operations and prospects of the Company.

         2.14 Transactions with Affiliates. Except as set forth in Schedule 2.13
or Schedule 2.14,  there are no loans,  leases,  royalty  agreements,  guarantee
agreements or other  agreements  between (i) the Company or any of its customers
or  suppliers  and (ii) any  officer,  employee,  consultant  or director of the
Company or any person  owning five  percent or more of the capital  stock of the
Company or, to the Company's  knowledge,  any member of the immediate  family of
such officer, employee,  consultant,  director or stockholder or any corporation
or other entity controlled by such officer,  employee,  consultant,  director or
stockholder,  or a member of the  immediate  family of such  officer,  employee,
consultant,  director or stockholder, and, except as set forth on Schedule 2.14,
since June 30,  1997,  the  Company has not repaid any  principal  amount of any
loans from any such person.

         2.15  Assumptions  or Guaranties of  Indebtedness.  The Company has not
assumed,  guaranteed,  endorsed or  otherwise  become  directly,  indirectly  or
contingently liable for any indebtedness of any other person.

         2.16 Investments. Except as set forth in Schedule 2.16, the Company has
not made any loans or advances to any person that are outstanding on the date of
this  Agreement  in excess of $50,000 in the  aggregate,  nor is it committed or
obligated to make any such loan or advance,  nor does the Company own any equity
securities,  assets comprising the business of,  obligations of, or any interest
in, any person.

         2.17 Title to Assets. The Company has a ninety-nine percent interest in
a  limited  partnership  that has good and  marketable  title in fee to the real
property on which the Company's  principal executive offices are located and the
Company  enjoys  peaceful and  undisturbed  possession  of its real and personal
property under all leases under which it is operating.  The limited  partnership
agreement relating to such interest and all of such leases are valid and in full
force and effect,  and the Company is in material  compliance  with such limited
partnership agreement and all such leases, which are set forth on Schedule 2.17.
The Company has good and merchantable  title to all of its other assets.  All of
such  assets  are  free of any  mortgages,  pledges,  charges,  liens,  security
interests or other encumbrances, except those set forth in Schedule 2.17.


                                                         6

<PAGE>



         The Company has taken  reasonable  measures to protect and preserve the
security and confidentiality of its analytical methods,  trade secrets and other
confidential  information  (the  "Proprietary  Information").  All employees and
consultants  of the  Company  involved  in the  design,  review,  evaluation  or
development  of  Proprietary   Information  have  executed  valid  nondisclosure
agreements. None of the Proprietary Information, to the Company's knowledge, has
been used,  divulged or appropriated  for the benefit of any person or otherwise
to the  detriment of the Company.  To the  Company's  knowledge,  no employee or
consultant  of the  Company  has used  the  intellectual  property,  proprietary
property or information,  trade secrets or other confidential information of any
other person in the course of their work for the Company, and the conduct of the
Company's business as currently operated and as proposed to be operated does not
and will not conflict with or infringe upon such property,  information or trade
secrets.  Except  pursuant to the terms of any licenses or other  agreements set
forth in Schedule  2.18,  the Company has no obligation to compensate any person
to use, license or sell any such property,  information or trade secrets and the
Company has not granted any person any license or other right to the Proprietary
Information, whether requiring payment of royalties or not.

         2.18  Material  Contracts.  Except  as set  forth in  Schedule  2.18 or
Schedules 2.13,  2.14, 2.15 or 2.16, the Company is not a party to any contract,
agreement,  instrument,  commitment,  obligation,  plan or arrangement  (i) that
would be required to be  disclosed  in or filed as an exhibit to a  Registration
Statement on Form S-1 filed with the Securities and Exchange Commission, or (ii)
with any customer or supplier  providing  for payments in excess of $50,000 (all
such contracts,  agreements,  instruments,  commitments,  obligations, plans and
arrangements collectively being referred to herein as "Contracts").  The Company
has made available to the Purchasers or their  representatives true, correct and
complete copies of all written  Contracts.  Schedule 2.18 contains a list of all
written Contracts and an accurate and complete description of all Contracts that
are not in writing.

         Except as set forth in Schedule  2.18, all of the Contracts are in full
force and effect,  the Company and each other party to each of the Contracts has
performed all the obligations  required to be performed by it to date, and there
is not under any of the  Contracts any existing  default,  or any failure of the
Company to perform,  which failure,  with notice or lapse of time or both, would
constitute such a default.  The Company has no present  expectation or intention
of not fully performing all its obligations  under each of the Contracts and has
no  knowledge of any breach or  anticipated  breach by any other party to any of
the Contracts.  Except as set forth in Schedule 2.18,  none of the Contracts has
been terminated or notice of termination  given with respect thereto,  no notice
has been given by an party  thereto of any  alleged  default  thereunder  by any
party thereto, and the Company is aware of no intention or right of any party to
any Contract to declare a default by another party to any Contract. There exists
no actual or threatened termination, cancellation, or limitation of the business
relationship of the Company with any party to any Contract.  Except as set forth
in Schedule  2.18,  no customer of the Company has  notified the Company that it
intends to terminate or change

                                                         7

<PAGE>



its business relationship with the Company following the consummation of the
transactions contemplated hereby.

         As of the dates of the Company's Financial Statements,  the Company did
not have any material liability or commitment,  contingent or otherwise, arising
out of any Contract and not adequately  reflected in or reserved  against in the
Financial  Statements.  Except  as set  forth  on  Schedule  2.18,  none  of the
Contracts  contain  noncompetition,  exclusivity or other provisions that in any
manner  restrict or in the future could restrict the Company's  operations.  The
Company has not  recorded on its  Financial  Statements  for any period  revenue
attributable  to services to be provided  under any  Contract  that had not been
performed by the Company during such period.  As of October 3, 1997, the Company
had been engaged to perform  approximately  $6.479 million of services for which
revenue had not been recorded on the Financial  Statements,  which is consistent
with the Company's  experience  during the last three fiscal years.  The Company
has not incurred  material  losses in connection with any Contract that have not
been recorded on the Company's Financial Statements,  other than as set forth on
Schedule 2.18.

         2.19 ERISA.  Except as set forth on Schedule 2.19, the Company makes no
contributions  to, and has no present  intention to make  contributions  to, any
employee  pension  benefit  plans for its  employees  which are  subject  to the
Employee  Retirement  Income  Security Act of 1974,  as amended  ("ERISA").  The
Company  has  never  contributed  to or  been  required  to  contribute  to  any
multi-employer plan which is subject to ERISA.

         2.20 Insurance.  The Company carries insurance  covering its properties
and business  adequate and customary  for the type and scope of the  properties,
assets and business,  and similar to companies of comparable  size and condition
similarly  situated in the same industry in which the Company  operates,  but in
any event in amounts sufficient to prevent the Company from becoming a coinsurer
or self-insurer, with provision for reasonable deductible amounts.

         2.21  Registration  Rights.  Except  for  the  rights  granted  to  the
Purchasers pursuant to the Registration  Rights Agreement,  no person has demand
or other rights to cause the Company to file any  registration  statement  under
the  Securities  Act relating to any  securities  of the Company or any right to
participate in any such registration statement.

         2.22  Absence of Certain  Developments.  Except as provided in Schedule
2.22  attached  hereto,  since  September  30, 1997,  there has been no material
adverse  change in the  business,  assets,  operations,  affairs,  prospects  or
financial condition of the Company, and the Company has not:

                  (a)      entered into any transaction, agreement or commitment
other than in the ordinary course of business;

                  (b)  entered  into or  agreed to enter  into any  transaction,
agreement or commitment  or suffered the  occurrence of any event or events that
has interfered or is

                                                         8

<PAGE>



reasonably  likely to  interfere  with the usual  operations  of the business or
that, singly or in the aggregate, has or is reasonably likely to have a material
adverse effect on the Company's business or results of operations;

                  (c)  issued,  repurchased  or  redeemed  or  agreed  to issue,
purchase or redeem any stock, bonds or other corporate securities or any rights,
options or warrants with respect thereto, or paid any dividends on any shares of
the Company's capital stock;

                  (d) borrowed  any amount or incurred or become  subject to any
liabilities  (absolute or contingent) except current liabilities in the ordinary
course of  business  comparable  in nature  and  amount to  current  liabilities
incurred in the ordinary course of business during the comparable portion of its
prior fiscal year,  as adjusted to reflect the current  nature and volume of the
Company's  business,  or discharged or satisfied any lien or encumbrance or paid
any  obligation  or  liability  (absolute  or  contingent),  other than  current
liabilities paid in the ordinary course of business;

                  (e)  mortgaged  or  pledged  any of its  assets,  tangible  or
intangible, or subjected them to any liens, charge or other encumbrance,  except
liens for current property taxes not yet due and payable;

                  (f)      sold, assigned or transferred any assets, except in 
the ordinary course of business;

                  (g) made any  changes in employee  compensation  except in the
ordinary course of business and consistent with past practices;

                  (h) made capital  expenditures  or  commitments  therefor that
aggregate in excess of $50,000; or

                  (i) incurred any material liability, obligation or commitment,
contingent  or  otherwise,  including  those  arising  out of any  Contract,  or
incurred any material losses in connection with any Contract.

         2.23 Books and Records. The books of account,  order books, records and
documents  of  the  Company  accurately  and  completely  reflect  all  material
information relating to the business of the Company, the location and collection
of its assets, and the nature of all transactions giving rise to the obligations
or accounts receivable of the Company.

         2.24 Disclosure.  Neither this Agreement,  the Financial Statements nor
any other agreement, document, or certificate furnished to any of the Purchasers
or  their  counsel  by or on  behalf  of the  Company  in  connection  with  the
transactions  contemplated  hereby  contains any untrue  statement of a material
fact or omits to state a material fact necessary in order to make the statements
made or  contained  herein or therein,  in light of the  circumstances  in which
made, not misleading.  This section does not relate or refer to any predictions,
projections, forecasts or estimates of future operations provided by or

                                                         9

<PAGE>



on  behalf  of the  Company,  except  that  all such  predictions,  projections,
forecasts and estimates  provided by the Company to the Purchasers were prepared
in good faith. There is no fact known to the Company that has not been disclosed
herein or in writing to the Purchasers and that materially adversely affects, or
that the  Company  believes  is  reasonably  likely in the future to  materially
adversely affect,  the business,  operations,  properties,  assets or condition,
financial or otherwise, of the Company.

         2.25 Brokers or Finders.  Except for Pennsylvania  Merchant Group Ltd.,
which shall  receive a fee of $ 227,500  paid by the  Company,  no person has or
will have, as a result of the transactions  contemplated by this Agreement,  any
right, interest or claim against or upon the Company for any commission,  fee or
other compensation as a finder or broker because of any action by the Company or
its agents.

Section 3         REPRESENTATIONS AND WARRANTIES OF PURCHASERS.

         Each of the Purchasers  hereby  represents and warrants,  severally but
not jointly, to the Company as follows:

         3.1 Investment  Representations.  Each Purchaser intends to acquire the
Shares, the Warrants, the Contingent Warrants, and the Conversion Shares for its
own  account.  The  Shares,  the  Warrants,  the  Contingent  Warrants,  and the
Conversion Shares are being acquired by it for investment and not with a view to
distribution  or resale  thereof.  Each Purchaser  understands  and agrees that,
until  registered  under the Securities Act or transferred  pursuant to Rule 144
under  the  Securities  Act,  all  certificates  representing  the  Shares,  the
Warrants,  any Contingent Warrants and the Conversion Shares shall bear a legend
reading substantially as follows:

         The securities represented by this certificate have not been registered
         under the Securities Act of 1933 or applicable  state  securities laws.
         These  securities may not be offered for sale,  sold,  delivered  after
         sale,  transferred,  pledged  or  hypothecated  in  the  absence  of an
         effective registration statement covering such securities under the Act
         and any applicable  state  securities  laws, or the  availability of an
         exemption from registration thereunder.

         3.2 Access to Information. Purchasers or their representatives have had
the  opportunity to ask questions of and receive  answers from management of the
Company concerning the Company's business, assets, financial condition,  results
of operations, and liabilities.

         3.3  Sophistication  and  Knowledge.  Each  Purchaser is an  accredited
investor as defined in  Regulation D under the  Securities  Act.  Purchasers  or
their  representatives  have the requisite knowledge and experience in financial
and business  matters to render them fully capable of evaluating  the merits and
risks of the purchase of the Shares and the  Warrants.  Each  Purchaser can bear
the  economic  risks of its  investment  and can afford a  complete  loss of its
investment.

                                                        10

<PAGE>




         3.4 Power.  Each  Purchaser  has full power and  authority  to make the
foregoing  representations  and to enter into and to perform this  Agreement and
the Ancillary Agreements in accordance with their terms. CAI is a duly organized
and validly  existing  partnership  in good  standing  under the laws of Quebec,
Canada.  Aster is a duly  organized  and validly  existing  corporation  in good
standing  under the laws of France.  Each  Purchaser  has obtained each required
authorization, consent, approval, license, qualification, exemption of or filing
or registration with any court or governmental  department,  commission,  board,
bureau, agency or instrumentality,  domestic or foreign, necessary in connection
with (i) the execution and delivery by such  Purchaser of this  Agreement or the
Ancillary  Agreements,  (ii) its  purchase of the Shares,  the  Warrants and the
Contingent  Warrants,  and (iii) its performance of its  obligations  under this
Agreement or the Ancillary Agreements.

         Each Purchaser hereby  acknowledges  that the Company is relying on the
representations  and  warranties  made by such  Purchaser  in this  Section 3 in
connection  with the Company's  representation  herein that it has complied with
all applicable federal and state securities laws,  including the Securities Act,
in connection with the offer, issuance and sale of the Shares, the Warrants, and
the Contingent Warrants.

Section 4                  COVENANTS.

         4.1 Use of Proceeds.  The Company  shall use the proceeds from the sale
of the Shares and the Warrants to acquire instruments and software identified by
management  and  approved  by the  Board of  Directors,  to fund  the  Company's
expansion,  and for working capital and general  corporate  purposes,  including
acquisitions.

         4.2 Best  Efforts  Cooperation.  Until the  Closing,  the  Company  and
Purchasers shall use their best efforts in good faith to perform and fulfill all
conditions and  obligations to be fulfilled or performed by them  hereunder,  to
the end that the  transactions  contemplated  hereby  will be fully  and  timely
consummated.

         4.3      General Covenants.  The Company and Purchasers agree:

         (a) if any event should occur,  either within or without the control of
any party,  that would prevent  fulfillment of the conditions to the obligations
of any  party  hereto  to  consummate  the  transactions  contemplated  by  this
Agreement or the Ancillary Agreements, to use its or their reasonable efforts to
cure the same as expeditiously as possible;

         (b)  to  cooperate   fully  with  each  other  in  preparing,   filing,
prosecuting,  and taking any other actions that may be reasonable  and necessary
to obtain the consent of any governmental instrumentality, or any third party to
accomplish  the  transactions  contemplated  by this Agreement and the Ancillary
Agreements;


                                                        11

<PAGE>



         (c)  to  deliver  such  other  instruments,   certificates,   consents,
endorsements,  assignments,  assumptions, and other documents or instruments, in
form  reasonably  acceptable  to  the  parties  and  their  counsel,  as  may be
reasonably  necessary  to carry  out  and/or  to  comply  with the terms of this
Agreement and the Ancillary Agreements and the transactions  contemplated herein
and therein; and

         (d) to confer on a regular  basis with each  other,  report on material
operational  matters and promptly advise each other orally and in writing of any
change or event having, or which,  insofar as can reasonably be foreseen,  could
have a material  adverse  effect on the business or operations of the Company or
which would cause or constitute a material breach of any of the representations,
warranties or covenants of any party contained herein.

         4.4  Public  Announcements.  No public  announcements  shall be made by
either party without  prior consent of the other with respect to this  Agreement
or the transactions contemplated hereby, which consent shall not be unreasonably
withheld.

         4.5  Confidentiality.   CAI  and  their   representatives   shall  keep
confidential  all  confidential  information of the Company  consistent with the
terms of the  confidentiality  agreement dated November 10, 1997 between CAI and
the Company,  and Aster and their  representatives  shall keep  confidential all
confidential  information  of the  Company  consistent  with  the  terms  of the
confidentiality  agreement dated November 6, 1997 between Aster and the Company.
Any party to whom the  Purchasers  may assign  their rights to purchase all or a
portion of the Shares and Warrants  pursuant to Section 1.1 shall be required to
enter into a similar confidentiality agreement with the Company.

         4.6.  Charter  Amendments.  The Company  shall use its best  efforts to
obtain  prior to April 30, 1998 the  approval of its  stockholders  to amend the
Company's  Charter (i) to increase the number of shares of Common Stock that the
Company  is  authorized  to  issue  to a number  at  least  sufficient  to allow
Purchasers  to acquire the number of shares of Common Stock to which  Purchasers
would be entitled upon exercise of the Warrants,  and (ii) to provide that prior
to the  declaration  by the  Corporation  of any  dividend  on any  class of the
capital stock of the  Corporation,  such dividend  shall have been approved by a
vote of those  members  of the Board of  Directors  elected  exclusively  by the
holders of the Company's  Class A Convertible  Preferred  Stock.  The Purchasers
each agree that the Shares shall be voted in favor of such  Charter  amendments.
Upon the approval of such a charter amendment, the Company shall deliver to each
Purchaser an opinion of counsel concerning the validity and effectiveness of the
charter  amendment and otherwise  substantially  in the same form as the opinion
provided pursuant to Section 5.5(a).

         4.7 Sales and Use Taxes.  The Company shall pay any sales and use taxes
that may be imposed or due in  connection  with the  consummation  of any of the
transactions contemplated by this Agreement.

         4.8 Validity of Warrants.  The Company  hereby  covenants that it shall
not at any time assert any claim, and that it shall promptly  indemnify and hold
harmless the

                                                        12

<PAGE>



Purchasers  against any losses,  damages or expenses  (including legal expenses)
that any Purchaser  may incur or suffer in connection  with the assertion by any
third party of any claim,  that the  Warrants  have not been  authorized  by all
required corporate action, have not been duly executed and delivered, or are not
legal,  valid and binding  obligations  of the Company  enforceable  against the
Company in accordance  with their terms. In the event any such claim is asserted
by any party,  each Purchaser  shall have the option of electing to accept,  and
the Company shall issue, the Contingent  Warrants pro rata based upon the number
of shares underlying Warrants held by such Purchaser.  This election shall be in
addition to and not in lieu of any rights such  Purchaser  may have at law or in
equity as the result of a breach of this Section 4.8.

Section 5         CONDITIONS PRECEDENT TO PURCHASERS' OBLIGATIONS TO PURCHASE
                  THE SHARES AND THE WARRANTS.

         The  obligations  of each  Purchaser  to  purchase  the  Shares and the
Warrants are subject to the  satisfaction,  or waiver by the Purchasers,  of the
following conditions, at or prior to the Closing:

         5.1  Representations  and Warranties.  Each of the  representations and
warranties of the Company set forth in Section 2 hereof shall be true,  accurate
and correct on the date of the Closing.

         5.2  Technology  Sharing  Agreement.  Aster and the Company  shall have
entered  into a  Technology  Sharing  Agreement  substantially  in the  form  of
Schedule 5.2.

         5.3 Registration Rights Agreement. The Purchasers and the Company shall
have entered into a Registration  Rights Agreement  substantially in the form of
Schedule 5.3.

         5.4 Articles Supplementary.  The Company shall have duly filed with the
Maryland State  Department of Assessments and Taxation  ("Department")  articles
supplementary  including the terms of the Shares set forth in Schedule 1.1B (the
"Articles Supplementary") and the Articles Supplementary will have been accepted
by the Department and will be effective.

         5.5 Documentation at Closing.  The Purchasers shall have received prior
to or at the Closing each of the following documents:

         (a) The  opinion  of Ober,  Kaler,  Grimes & Shriver,  counsel  for the
Company,  in form and  substance  reasonably  satisfactory  to  counsel  for the
Purchasers, covering the matters set forth in Schedule 5.5(a).

         (b) A certificate of the President and the Chief  Financial  Officer of
the Company  stating  that the  representations  and  warranties  of the Company
contained  in Section 2 hereof and  otherwise  made by the Company in writing in
connection with the transactions  contemplated hereby are true and correct as of
the Closing and that all conditions  required to be performed prior to or at the
Closing have been performed or waived.

                                                        13

<PAGE>



         (c) Any consents or waivers of  governmental  entities or third parties
required to be  obtained at or prior to the Closing to execute and deliver  this
Agreement  and the  Ancillary  Agreements  and to  carry  out  the  transactions
contemplated hereby and thereby.

         5.6 No  Actions  or  Proceedings.  There  shall  not be any  action  or
proceeding by or before any court or other  governmental body that shall seek to
restrain,   prohibit  or  invalidate  the  transactions   contemplated  by  this
Agreement.

         5.7 Business  Combination  Act  Opt-out.  The Board of Directors of the
Company  shall have adopted a resolution  under Section  3-603(c)(1)(ii)  of the
Maryland  General  Corporation Law ("MGCL")  pursuant to which the Company shall
have opted out of the  requirements of Section 3-602 of the MGCL with respect to
any  business  combination  (as  defined  in the MGCL)  involving  either of the
Purchasers or their permitted assignees under Section 1.1 of this Agreement.

Section 6         CONDITIONS PRECEDENT TO COMPANY'S OBLIGATIONS TO SELL THE
                  SHARES AND THE WARRANTS.

         The  obligations of the Company to sell the Shares and the Warrants are
subject  to the  satisfaction,  or  waiver  by  the  Company,  of the  following
conditions, at or prior to the Closing:

         6.1  Representations  and Warranties.  Each of the  representations and
warranties  of each of the  Purchasers  set forth in  Section 3 hereof  shall be
true, accurate and correct on the date of the Closing.

         6.2  Technology  Sharing  Agreement.  Aster and the Company  shall have
entered  into a  Technology  Sharing  Agreement  substantially  in the  form  of
Schedule 5.2.

         6.3 Documentation at Closing.  The Company shall have received prior to
or at the Closing a certificate of authorized officers of each Purchaser stating
that the representations and warranties of such Purchaser contained in Section 3
hereof and otherwise  made by such  Purchaser in writing in connection  with the
transactions contemplated hereby are true and correct as of the Closing and that
all  conditions  required to be  performed  prior to or at the Closing have been
performed or waived.

         6.4 No  Actions  or  Proceedings.  There  shall  not be any  action  or
proceeding by or before any court or other  governmental body that shall seek to
restrain,   prohibit,  or  invalidate  the  transactions  contemplated  by  this
Agreement.

Section 7         CONTINGENT WARRANTS.

         7.1 Contingent Warrants. In the event that (i) the Company shall not by
April 30,  1998 have filed an amended  charter  with the  Secretary  of State of
Maryland  increasing the number of shares of the Company's  Common Stock that it
is  authorized  to issue by at least 10 million  shares and reserved such shares
for issuance upon exercise

                                                        14

<PAGE>



of the Warrants, or (ii) the Company shall have failed to consummate the sale of
the Shares or the  Warrants by  December  31, 1997 (or such later date as may be
unanimously  agreed by the parties hereto) for any reason other than a breach or
default of this  Agreement  by the  Purchasers,  including  a failure to pay the
Aggregate  Purchase  Price,  or the  failure  by the  Purchasers  to  satisfy  a
condition set forth in Section 6 hereof, then, in either such event, the Company
shall,  for no additional  consideration,  issue to the  Purchasers  warrants to
purchase an aggregate of 2,750,000  shares of the Common Stock of the Company at
an exercise  price of $0.60 per share and otherwise  having terms  substantially
identical  to the  terms  of  the  Warrants  (the  "Contingent  Warrants").  The
Contingent  Warrants  shall be issued to the  Purchasers pro rata based upon the
number of  Shares  held by each  Purchaser  or the  number  of Shares  that each
Purchaser  would have  acquired but for the failure of the Company to consummate
the transactions contemplated by this Agreement, as the case may be.

         7.2 Opinion of Counsel.  Simultaneously with the issuance of Contingent
Warrants,  the Company will  deliver to each  Purchaser an opinion of counsel in
form and substance  reasonably  satisfactory  to such  Purchaser  concerning the
validity of the Contingent Warrants and otherwise substantially in the same form
as the opinion provided pursuant to Section 5.5 (a).

         7.3 Cancellation of Warrants. Each Purchaser shall deliver the Warrants
to the Company for  cancellation  promptly upon receipt of  Contingent  Warrants
issued as a result of failure of the  Company to amend its  charter as set forth
in Section 7.1.

Section 8         MISCELLANEOUS.

         8.1 Survival of Representations  and Warranties.  Every  representation
and warranty of each of the parties set forth in this  Agreement  and all of the
rights and  remedies  of the other  parties  related to  misrepresentations  and
inaccuracies  related  thereto shall  survive,  and not be deemed waived by, the
Closing,  and shall be effective  regardless of any investigation  that may have
been made at any time by or on behalf of any party or its  directors,  officers,
employees, or agents.

         8.2  Expenses.   The  parties  shall  pay  their  respective   expenses
(including the fees,  disbursements,  and expenses of their respective attorneys
and  accountants)  in connection  with the  negotiation  and preparation of this
Agreement and the consummation of the transactions contemplated hereby.

         8.3 Notices.  Each party hereto shall  promptly give written  notice to
the other parties upon becoming  aware of the occurrence of, or any impending or
threatened  occurrence  of, any event that would cause or constitute a breach of
any  of  its  representations,   warranties,  or  covenants  contained  in  this
Agreement,  and such party  shall use its best  efforts  to prevent or  promptly
remedy the same.  Any  notice or other  communication  required  or which may be
given  hereunder shall be in writing and shall be deemed to have been duly given
on the date  delivered  if  delivered  personally  or sent by  facsimile  to the
persons identified below, one business day following deposit with a

                                                        15

<PAGE>



reputable overnight courier, or three business days after deposit in the U.S. 
mail if mailed by certified or registered mail, return receipt requested, 
addressed as follows:

                  If to the Company, to:

                           PharmaKinetics Laboratories, Inc.
                           302 West Fayette Street
                           Baltimore, MD 21201
                           Attention: James K. Leslie, President
                           Telephone:       (410) 385-4500
                           Facsimile:       (410) 385-1957

                  with a copy to:

                           Ober, Kaler, Grimes & Shriver
                           120 E. Baltimore Street
                           Baltimore, MD 21202
                           Attention: Melissa A. Warren, Esquire
                           Telephone:       (410) 347-7684
                           Facsimile:       (410) 547-0699

                  If to either Purchaser, to:

                           CAI Advisors & Co.
                           767 Fifth Avenue, 5th Floor
                           New York, NY 10153
                           Attention:  Leslie B. Daniels
                           Telephone:       (212) 319-2525
                           Facsimile:       (212) 319-0232

                  with a copy to:

                           Dyer Ellis & Joseph PC
                           600 New Hampshire Ave., N.W.
                           Washington, DC 20037
                           Attn: Michael Joseph
                           Telephone:       (202) 944-3000
                           Facsimile:       (202) 944-3068

Any party may change its address to which notices or other communications are to
be sent by giving  written  notice of any such  change  in the  manner  provided
herein for giving notice.

         8.4 Modification or Waiver. This Agreement may be amended, modified, or
superseded at any time by a written instrument  executed by the Company and each
Purchaser,  and any of the terms,  covenants,  representations,  warranties,  or
conditions

                                                        16

<PAGE>



hereof may be waived by the party intended to be benefited  hereby. No waiver of
any nature, in any one or more instances,  shall be deemed to be or construed as
a further or continued  waiver of any condition or any breach of any other term,
representation, or warranty in this Agreement.

         8.5 Binding Effect and Assignment. This Agreement shall be binding upon
and inure to the benefit of the parties hereto and their  respective  successors
and assigns.

         8.6      Governing Law.  This Agreement shall be governed by and 
construed in accordance with the laws of the state of Maryland.

         8.7 Section Headings.  The Section headings contained in this Agreement
are inserted for  convenience of reference only and shall not affect the meaning
or interpretation of this Agreement.

         8.8  Further  Assurances.  Subject to the terms and  conditions  herein
provided,  each of the parties agrees to use all reasonable  efforts to take, or
cause to be  taken,  all  action  and to do,  or cause  to be done,  all  things
necessary,  proper,  or  advisable  under  applicable  laws and  regulations  to
consummate  the purchase and sale of the Shares and Warrants in accordance  with
the terms of this Agreement. In case at any time any further action is necessary
or  desirable  to carry out the  purposes  of this  Agreement,  the  appropriate
officers of each party to this  Agreement are hereby  directed and authorized to
use their best efforts to effectuate all such action.

         8.9 Entire  Agreement.  This  Agreement  and the  Ancillary  Agreements
embody the  entire  agreement  and  understanding  between  the  parties  hereto
relating to the subject matter hereof and supersede any prior letters of intent,
agreements, and understandings relating to the subject matter hereof, other than
confidentiality agreements executed by the parties.

         8.10 No Third Party Beneficiaries.  Nothing expressed or referred to in
this  Agreement  is intended or shall be construed to give any person other than
the  parties to this  Agreement  or their  respective  successors  or  permitted
assigns any legal or equitable  right,  remedy,  or claim under or in respect of
this Agreement or any provision  contained herein, it being the intention of the
parties  to this  Agreement  that  this  Agreement  shall  be for the  sole  and
exclusive benefit of such parties or such successors and assigns and not for the
benefit of any other person.

         8.11  Counterparts.  Separate copies of this Agreement may be signed by
the parties hereto, with the same effect as though all of the parties had signed
one copy of this Agreement.

         8.12  Severability.  If any provision of this  Agreement  shall be held
invalid under any  applicable  law, such  invalidity  shall not affect any other
provision  of this  Agreement  that  can be given  effect  without  the  invalid
provision and, to this end, the provisions hereof are severable.

                                                        17

<PAGE>



         8.13  Termination.  In the event that the Company  shall have failed to
consummate the sale of the Shares and the Warrants by December 31, 1997 (or such
later date as may be unanimously agreed by the parties hereto),  and the Company
has, as a result, duly issued the Contingent  Warrants,  then the obligations of
both parties  hereunder shall terminate.  In the event that the Purchasers shall
have  determined  not to  purchase  the Shares and the  Warrants  and shall have
provided  written notice to that effect to the Company,  then the obligations of
the Company hereunder shall terminate.


                  [Remainder of Page Intentionally Left Blank]

                                                        18

<PAGE>



         IN  WITNESS  WHEREOF,   the  undersigned  parties  have  executed  this
Agreement as of the date first above written.

                                            PHARMAKINETICS LABORATORIES, INC.

                                            By:
                                                     James K. Leslie
                                    President

                                            CAI ADVISORS & CO.

                                            By:
                                                     Leslie B. Daniels
                                     Partner

                                            ASTER-CEPHAC

                                            By:
                                                     John J. Thebault
                                                 Chief Executive and President

                                                        19

<PAGE>



                               SCHEDULE 1.1B

        DESCRIPTION AND DESIGNATION OF CLASS A CONVERTIBLE PREFERRED STOCK

1.       DESIGNATION AND AMOUNT

         A total of 833,300 shares of the Corporation's Preferred Stock shall be
designated the "Class A Convertible Preferred Stock."

2.       VOTING RIGHTS

         2.1 General Each holder of Class A Convertible Preferred Stock shall be
entitled to vote on all matters submitted to a vote of the holders of the Common
Stock of the  Corporation  and,  with  respect  to each  such  matter,  shall be
entitled to that  number of votes equal to the number of whole  shares of Common
Stock into which such  holder's  shares of Class A Convertible  Preferred  Stock
could be converted,  pursuant to the provisions of Section 5, on the record date
for the determination of stockholders entitled to vote on such matters, or if no
such  record  date is  established,  on the date such  vote is taken.  Except as
otherwise provided herein or otherwise required by law, the holders of shares of
Class A  Convertible  Preferred  Stock and the holders of shares of Common Stock
shall  vote  together  as a  single  class  on  all  matters  submitted  to  the
stockholders of the Corporation.

         2.2      Director Election Rights

         (a)      Definitions   For purposes of this Subsection 2.2:

                  "Affiliate",  with respect to any person, shall mean any other
         person   that,   directly   or   indirectly,   through   one  or   more
         intermediaries,  controls, is controlled by, or is under common control
         with such person,  or any other person that is a partner of such person
         in any general or limited partnership;

                  "Conversion  Shares"  means the sum of (A) the number of whole
         shares of Common  Stock  into which the  outstanding  shares of Class A
         Convertible  Preferred Stock are convertible pursuant to the provisions
         of Section 5, plus (B) the  number of shares of Common  Stock  owned of
         record by the Initial Holders, regardless of how or when acquired.

                  "Initial  Holders"  means CAI  Advisors & Co.,  Astero  Cephac
         S.A.,  any Affiliate of CAI Advisors & Co. or Astero  Cephac S.A.,  and
         any  holder  of Class A  Convertible  Preferred  Stock or  warrants  to
         purchase Common Stock that obtained such preferred stock or warrants by
         assignment  from CAI Advisors & Co. or Astero  Cephac S.A.  pursuant to
         the  terms  of  that  certain  Preferred  Stock  and  Warrant  Purchase
         Agreement  dated  December  3, 1997 by and among the  Corporation,  CAI
         Advisors & Co., and Astero Cephac S.A. (the "Purchase Agreement");


                                                         1

<PAGE>



                  "Total  Shares  Outstanding"  means  the sum of (A) the  total
         number  of shares of Common  Stock  outstanding  and (B) the  number of
         whole shares of Common Stock into which the outstanding shares of Class
         A  Convertible   Preferred  Stock  are  convertible   pursuant  to  the
         provisions of Section 5.

         (b)  Director  Election  Rights of  Holders  So long as the  Conversion
Shares  constitute at least ten percent  (10%) of the Total Shares  Outstanding,
the holders of Class A Convertible  Preferred Stock, voting as a separate class,
shall have the right to elect that number of Directors to the Board of Directors
of the  Corporation  (the "Board")  that bears the same  proportion to the total
number of  directors  on the Board as the  Conversion  Shares  bear to the Total
Shares Outstanding, rounded up to the next whole number; provided, however, that
so long as the Conversion Shares  constitute at least thirty-five  percent (35%)
of the Total Shares  Outstanding,  the holders of Class A Convertible  Preferred
Stock  shall have the right to elect at least fifty  percent  (50%) of the Board
members. For purposes of this Subsection 2.2(b), the number of Conversion Shares
shall be determined  on the record date for the  determination  of  stockholders
entitled  to vote on the  election  of  directors,  or if no such record date is
established, on the date such vote is taken.

3.       DIVIDENDS

         If the Corporation declares a dividend on its Common Stock, each holder
of  shares  of  Class  A  Convertible  Preferred  Stock  shall  be  entitled  to
participate  in such  dividend as if such holder was the holder of the number of
whole  shares  of  Common  Stock  into  which  such  holder's  shares of Class A
Convertible  Preferred  Stock could be converted,  pursuant to the provisions of
Section 5, on the record date for the  determination  of holders of Common Stock
entitled to receive the declared dividend.

4.       LIQUIDATION, DISSOLUTION, OR WINDING-UP

         4.1 Preference Right Upon the liquidation,  dissolution,  or winding-up
of the  Corporation,  whether  voluntary or  involuntary,  before any payment or
distribution  shall be made to any holders of Common Stock or any other class or
series of capital stock of the Corporation  designated to be junior to the Class
A Convertible  Preferred  Stock,  the holders of Class A  Convertible  Preferred
Stock  shall  be  entitled  to be  paid  out of the  assets  of the  Corporation
available for distribution to its stockholders, whether from capital, surplus or
earnings (the  "Proceeds"),  an amount per share equal to the Preference  Amount
(as defined in  Subsection  4.2). If the Proceeds are  insufficient  to pay each
holder of Class A Convertible  Preferred  Stock an amount per share equal to the
Preference Amount, then each such holder shall share in the Proceeds in the same
proportion  that the  number of shares of Class A  Convertible  Preferred  Stock
registered  in the name of such  holder  bears to the total  number of shares of
Class A Convertible Preferred Stock outstanding.

         4.2  Preference  Amount  The  Preference  Amount  per  share of Class A
Convertible Preferred Stock shall be Five and 92.5/100 Dollars ($5.925).


                                                         2

<PAGE>



         4.3 Merger, Consolidation,  etc Upon any merger, consolidation or other
corporate   reorganization   or  combination  to  which  the  Corporation  is  a
non-surviving  party (other than a merger into  wholly-owned  subsidiary  of the
Corporation),  or any  sale of all or  substantially  all of the  assets  of the
Corporation,  the holders of Class A Convertible  Preferred  Stock that have not
converted  their shares to Common Stock  pursuant to Section 5 shall be entitled
to receive the cash,  securities or other property in the amount that they would
have received under Subsection 4.1 upon a liquidation.

5.       CONVERSION.

         5.1  Conversion  Right  and  Conversion  Rate  Any  holder  of  Class A
Convertible  Preferred  Stock shall have the right, at the holder's  option,  to
convert  at any  time,  or from  time to time,  any or all of the such  holder's
shares of Class A Convertible  Preferred Stock into fully-paid and nonassessable
shares  of the  Common  Stock  of the  Corporation,  subject  to the  terms  and
conditions of this Section 5. The number of shares of Common Stock  issuable for
each  share of Class A  Convertible  Preferred  Stock  upon any such  conversion
(herein  called the  "Conversion  Rate")  shall be 10 shares of Common Stock for
each share of Class A Convertible  Preferred Stock;  provided,  however, that if
the application of the then current  Conversion Rate to the aggregate  number of
shares of Class A Convertible  Preferred Stock surrendered by a single holder in
a single  transaction  would  result in a  fraction,  then the next lower  whole
number of shares of Common  Stock shall be issuable  upon such  conversion.  The
Conversion  Rate  shall be subject  to  adjustment  from time to time in certain
instances as provided in Section 5.3. The  Corporation  shall make no payment or
adjustment on account of any dividends accrued on the Common Stock issuable upon
such  conversion,  or on account of the  rounding  down to the next lower  whole
number of shares issuable upon any conversion.

         5.2  Manner  of  Conversion  In  order  to  convert  shares  of Class A
Convertible  Preferred Stock into Common Stock, the record holder of such shares
shall  surrender the  certificate  or  certificates  therefor,  duly endorsed or
accompanied  by duly  executed  stock  powers,  at the  principal  office of the
Corporation. Together with such certificates, the converting holder shall give a
written  conversion  notice to the  Corporation  of the  election  to  convert a
specified  number  of  shares  of  Class  A  Convertible  Preferred  Stock.  The
converting holder shall state in its notice of conversion the name or names that
shall appear on the certificate or  certificates  for Common Stock issuable upon
such conversion. The Corporation shall, as soon as practicable thereafter, cause
to be issued  and  delivered  to the  converting  holder,  or to the  converting
holder's  designated  transferees or nominees,  if permitted by applicable  law,
certificates  for the  number  of full  shares  of  Common  Stock to  which  the
converting  holder is entitled.  If the converting holder has elected to convert
only a portion of the shares of Class A Convertible  Preferred Stock represented
by the surrendered certificates,  the Corporation shall issue, at its expense, a
new  certificate  representing  the  unconverted  shares of Class A  Convertible
Preferred Stock, registered in the name of the converting holder, or in the name
or names of the  converting  holder's  designated  transferees  or nominees,  if
permitted by applicable law. Shares of Class A Convertible Preferred Stock shall
be deemed to have been  converted  as of the close of  business on the date when
the surrender of the certificates therefor and the giving of

                                                         3

<PAGE>



notice as required above has been completed.  The person or persons  entitled to
receive  the Common  Stock  issuable  upon  conversion  shall be treated for all
purposes as the record  holder or holders of such Common Stock at and after such
time.

         5.3.     Adjustment to Conversion Rate.

         (a) Generally.  In order to prevent  dilution of the conversion  rights
granted  under  Section 5.1 hereof,  the  Conversion  Rate in effect at any time
shall be subject to  adjustment  from time to time pursuant to this Section 5.3.
Any such adjustment  shall be automatic and shall not require any further action
on the part of the  Corporation  (except for the  preparation  of an  Adjustment
Certificate  pursuant  to  Section  5.4) or of any  registered  owner of Class A
Convertible Preferred Stock.

         (b) Sale or Issuance of Common Stock.  If and whenever the  Corporation
issues or sells,  or in  accordance  with  paragraph  (c) of this Section 5.3 is
deemed to have issued or sold, any shares of its Common Stock for  consideration
per share  less than  Fifty-Nine  and 25/100  Cents  ($0.5925)  (hereafter,  the
"Adjustment  Trigger  Price"),  then  immediately upon such issuance or sale (or
deemed  issuance or sale) the Conversion  Rate then in effect shall be increased
by multiplying such Conversion Rate by a fraction,  the numerator of which shall
be the sum of (i) the number of shares of Common Stock  outstanding  immediately
prior to such issuance or sale (or deemed issuance or sale) plus (ii) the number
of shares of Common Stock so issued or sold (or deemed issued or sold),  and the
denominator  of which  shall be the sum of (x) the  number  of  shares of Common
Stock outstanding immediately prior to such issuance or sale (or deemed issuance
or  sale)  plus the  number  of  shares  of  Common  Stock  that  the  aggregate
consideration   received  by  the   Corporation   (or  deemed  received  by  the
Corporation)  in connection  with such  issuance or sale (or deemed  issuance or
sale), determined in accordance with Subsection 5.3(e) hereof, would purchase at
a price per share equal to the Adjustment  Trigger  Price.  For purposes of this
Section  5.3,  the term  "Common  Stock"  shall  include all  securities  of the
Corporation  having  characteristics  substantially  equivalent  to those of the
Corporation's Common Stock.

         (c) Deemed  Sale or  Issuance  of Common  Stock.  For  purposes of this
Section 5.3, the following  events shall be deemed an issuance or sale of Common
Stock:

                  (i)   Issuance  of  Rights,   Warrants  or  Options.   If  the
         Corporation  in any manner  grants any  rights,  warrants or options to
         subscribe  for or to purchase  Common Stock (such  rights,  warrants or
         options  being  herein  called  "Options")  and the price per share for
         which  Common  Stock is issuable  upon the  exercise of such Options is
         less than the Adjustment  Trigger Price,  then the total maximum number
         of shares of Common  Stock  issuable  upon the exercise of such Options
         shall be deemed to have been  issued and sold by the  Corporation  upon
         the grant of such  Options  for such price per share.  For  purposes of
         this  paragraph,  the  "price  per  share  for  which  Common  Stock is
         issuable" will be determined by dividing (x) the total amount,  if any,
         received or  receivable by the  Corporation  as  consideration  for the
         granting  of  such  Options,  plus  the  minimum  aggregate  amount  of
         additional

                                                         4

<PAGE>



         consideration  payable to the Corporation upon the exercise of all such
         Options,  by (B) the total  maximum  number  of shares of Common  Stock
         issuable upon the exercise of all such Options.  No further  adjustment
         of the  Conversion  Rate shall be made when shares of Common  Stock are
         actually issued upon the exercise of such Options.

                  (ii) Issuance of Convertible Securities. If the Corporation in
         any  manner  issues  or  sells  any  securities   convertible  into  or
         exchangeable  for  Common  Stock  (such   convertible  or  exchangeable
         securities being herein called "Convertible  Securities") and the price
         per share for which Common Stock is issuable  upon such  conversion  or
         exchange  is less than the  Adjustment  Trigger  Price,  then the total
         maximum  number of shares of Common Stock  issuable upon the conversion
         or exchange of such Convertible Securities shall be deemed to have been
         issued  and sold by the  Corporation  for such price per share upon the
         issuance or sale of such Convertible  Securities.  For purposes of this
         paragraph,  the "price per share for which  Common  Stock is  issuable"
         shall be  determined  by  dividing  (x) the total  amount  received  or
         receivable by the Corporation as consideration for the issuance or sale
         of such Convertible  Securities,  plus the minimum  aggregate amount of
         additional  consideration,  if any, payable to the Corporation upon the
         conversion  or exchange  thereof,  by (y) the total  maximum  number of
         shares of Common Stock  issuable upon the conversion or exchange of all
         such Convertible  Securities.  No further  adjustment of the Conversion
         Rate shall be made when shares of Common Stock are actually issued upon
         the conversion or exchange of such Convertible Securities.

                  (iii) Treatment of Expired Options and Unexercised Convertible
         Securities. Upon the expiration of any Option or the termination of any
         right  to  convert  or  exchange  any  Convertible  Securities  without
         exercise of the  underlying  option or right,  provided such Options or
         Convertible  Securities  are  not  reissued  by  the  Corporation,  the
         Conversion  Rate  then in  effect  hereunder  will be  adjusted  to the
         Conversion  Rate  that  would  have  been in effect at the time of such
         expiration or termination had such Option or Convertible  Security,  to
         the  extent  outstanding   immediately  prior  to  such  expiration  or
         termination, never been issued.

                  (iv) Integrated Transactions.  In case any Option is issued in
         connection  with  the  issuance  or sale  of  other  securities  of the
         Corporation together comprising one integrated  transaction in which no
         specific  consideration  is  allocated  to such  Option by the  parties
         thereto,  the  Option  shall  be  deemed  to  have  been  issued  for a
         consideration of One Cent ($0.01).

         (d) Certain Events  Excepted.  Notwithstanding  the other provisions of
this Section 5.3, the  following  events shall not trigger an  adjustment to the
Conversion Rate:

                  (i) the  issuance  or sale  (or  deemed  issuance  or sale) of
         Common Stock reserved for issuance in connection with the Conversion of
         Class A Convertible Preferred Stock;

                                                         5

<PAGE>




                  (ii) the  issuance  or sale (or  deemed  issuance  or sale) of
         Common  Stock  reserved  for  issuance  upon the  exercise  of warrants
         purchased under the Purchase Agreement; and

                  (iii) the grant of Options, or the issuance or sale (or deemed
         issuance or sale) of Common Stock, to officers,  employees,  directors,
         consultants or advisors of the Corporation pursuant to any stock option
         plan or restricted stock purchase plan adopted by the Corporation.

         (e) Calculation of Consideration  Received. If any Common Stock, Option
or  Convertible  Security  is issued or sold,  or deemed to have been  issued or
sold, for cash, the  consideration  received  therefor shall be deemed to be the
net amount of cash  received  by the  Corporation  therefor.  In case any Common
Stock,  Option or  Convertible  Security  is issued or sold for a  consideration
other than cash, the amount of the consideration other than cash received by the
Corporation shall be the fair market value of such consideration.  If any Common
Stock, Option or Convertible Security is issued in connection with any merger in
which the Corporation is the surviving corporation,  the amount of consideration
therefor  shall be deemed to be the fair market value of such portion of the net
assets and business of the non-surviving  corporation as is attributable to such
Common  Stock,  Option or  Convertible  Security,  as the case may be.  The fair
market  value of any  consideration  other  than  cash and  securities  shall be
determined by the Board of Directors of the Corporation.

         (f)  Dividend  in Common  Stock If the  Corporation  pays a dividend in
shares  of  its  Common  Stock,  the  Conversion  Rate  shall  be  increased  by
multiplying the Conversion  Rate then in effect by a fraction,  the numerator of
which shall be the sum of (A) the number of shares of Common  Stock  outstanding
at the  opening of  business  on the date fixed for such  dividend  plus (B) the
total number of shares constituting such dividend,  and the denominator of which
shall be the  number of shares of Common  Stock  outstanding  at the  opening of
business on the date fixed for such dividend.

         (g)  Subdivision or Combination of Common Stock.  If the Corporation at
any time  subdivides (by any stock split,  stock dividend,  recapitalization  or
otherwise)  the  outstanding  shares of Common  Stock  into a greater  number of
shares,  the  Conversion  Rate  and  the  Adjustment  Trigger  Price  in  effect
immediately  prior to such  subdivision will be,  respectively,  proportionately
increased and  decreased.  If the  Corporation  at any time combines (by reverse
stock split or otherwise) the outstanding  shares of Common Stock into a smaller
number of shares, the Conversion Rate and the Adjustment Trigger Price in effect
immediately  prior to such  combination will be,  respectively,  proportionately
decreased and increased.

         (h) Waiver of  Automatic  Adjustment.  An automatic  adjustment  to the
Conversion Rate or the Adjustment Trigger Price pursuant to this Section 5.3 may
not be  waived  except by  written  notice to the  Corporation  executed  by the
registered  owners  of 100  percent  of  then  outstanding  shares  of  Class  A
Convertible Preferred Stock.

                                                         6

<PAGE>



         5.4 Adjustment  Certificate The Treasurer or Chief Financial Officer of
the Corporation shall compute all required adjustments to the Conversion Rate or
the  Adjustment  Trigger  Price  under  this  Section  5  and  shall  prepare  a
certificate  setting forth the adjusted  Conversion  Rate or Adjustment  Trigger
Price and showing in detail the facts upon which the  adjustment  was based (the
"Adjustment  Certificate").  The  Treasurer  or Chief  Financial  Officer  shall
promptly file the Adjustment  Certificate  with the Transfer  Agent, if any, for
the Class A Convertible  Preferred  Stock and shall  promptly mail a copy of the
Adjustment  Certificate  to each record holder of Class A Convertible  Preferred
Stock.

         5.5      Notice of Certain Events   In case:

                  (i)   the Corporation shall declare a dividend payable in 
         Common Stock;

                  (ii)  of  any  capital   reorganization  of  the  Corporation,
         reclassification of the capital stock of the Corporation, consolidation
         or merger  of the  Corporation  with or into  another  corporation,  or
         conveyance of all or substantially all of the assets of the Corporation
         to another corporation; or

                  (iii) of the voluntary or involuntary dissolution, liquidation
         or winding-up of the Corporation;

then,  and in any such case,  the  Corporation  shall  cause to be mailed to the
Transfer Agent,  if any, for the Class A Convertible  Preferred Stock and to the
record holders of the outstanding shares of Class A Convertible Preferred Stock,
at least  twenty  days prior to the  record  date for any such  event,  a notice
disclosing  the  event to occur and the  record  date for  determination  of the
stockholders entitled to participate in such event.

         5.6 Common Stock Reserve The Corporation shall at all times reserve and
keep available,  out of its authorized but unissued Common Stock, solely for the
purpose  of  effecting  the  conversion  of the  shares  of Class A  Convertible
Preferred  Stock,  the full number of shares of Common Stock  issuable  upon the
conversion  of all shares of Class A  Convertible  Preferred  Stock from time to
time outstanding.

         5.7 Taxes The Corporation shall pay any and all issue taxes that may be
payable in respect of the  issuance or  delivery of shares of Common  Stock upon
conversion of shares of Class A Convertible Preferred Stock.

6.       RESTRICTIONS AND LIMITATIONS ON CORPORATE ACTION

         The  approval  by vote of the  holders  of at least a  majority  of the
outstanding  shares of Class A Convertible  Preferred Stock,  voting as a single
class,  each share of Class A Convertible  Preferred Stock to be entitled to one
vote in each  instance,  shall be required for any action by the  Corporation or
any amendment to the  corporate  charter if such  corporate  action or amendment
would (i) change or limit any of the rights,  preferences,  or privileges of the
Class A Convertible  Preferred  Stock, or (ii) authorize,  create,  or issue, or
obligate the Corporation to authorize,  create,  or issue,  additional shares of
Class A

                                                         7

<PAGE>



Convertible  Preferred  Stock or shares  of any  other  class or series of stock
having rights, preferences, or privileges senior to or on a parity with those of
the Class A Convertible Preferred Stock.

7.       NO IMPAIRMENT

         The  Corporation  will not, by  amendment of its  corporate  charter or
through any reorganization,  transfer of capital stock or assets, consolidation,
merger, dissolution, issue or sale of securities, or through any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms
of the Class A Convertible  Preferred Stock, but will at all times in good faith
assist in the carrying out of all such terms.

8.       NO REISSUANCE OF CLASS A CONVERTIBLE PREFERRED STOCK; TERMINATION

         No share or shares of Class A Convertible  Preferred  Stock acquired by
the Corporation by reason of conversion or otherwise shall be reissued,  and all
such shares shall be canceled,  retired and eliminated from the shares which the
Corporation is authorized to issue.  Upon the  cancellation  of all  outstanding
shares of the Class A Convertible  Preferred  Stock,  these  charter  provisions
regarding the Description and Designation of Class A Convertible Preferred Stock
shall terminate and have no further force and effect.

                                                         8

<PAGE>



                                 SCHEDULE 1.1(C)

                                 FORM OF WARRANT

THE  WARRANTS  AND  COMMON  STOCK  ISSUABLE  UPON THEIR  EXERCISE  HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933 OR APPLICABLE STATE SECURITIES LAWS.
THESE  SECURITIES  MAY NOT BE OFFERED  FOR SALE,  SOLD,  DELIVERED  AFTER  SALE,
TRANSFERRED, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT  COVERING  SUCH  SECURITIES  UNDER  THE ACT AND ANY  SUCH  LAWS OR THE
AVAILABILITY OF AN EXEMPTION FROM REGISTRATION THEREUNDER.

                        PHARMAKINETICS LABORATORIES, INC.

                          COMMON STOCK PURCHASE WARRANT

         1. Issuance.  For good and valuable  consideration the receipt of which
is  hereby   acknowledged,   PHARMAKINETICS   LABORATORIES,   INC.,  a  Maryland
corporation  (the  "Company"),  hereby  grants  to (the  "Holder")  the right to
purchase at any time and from time to time until 5:00 P.M. Eastern Standard Time
on December , 2000 (the "Expiration Date"),  fully paid and nonassessable shares
of the Company's  Common Stock,  par value $0.001 per share (the "Common Stock")
at an exercise price of $1.20 per share (the "Exercise  Price"),  subject to the
limitation  set forth in Section 2(b) and to  adjustment as set forth in Section
6.

         2.  Exercise.  (a) The warrants  represented by this  Certificate  (the
"Warrants") are exercisable, in whole or in part, by surrendering to the Company
(i) this  Certificate,  (ii) the  attached  form of  notice of  exercise  of the
Warrants,  and  (iii)  unless  the  Holder  elects  "cashless  exercise"  of the
Warrants,  cash or a  certified  or  official  bank  check in the  amount of the
aggregate  Exercise Price.  In the event the Holder elects cashless  exercise of
the  Warrants,  the Holder  shall be  entitled  to receive a number of shares of
Common Stock equal in Market Value to the difference between the Market Value of
the shares of Common  Stock  issuable  upon  exercise  of the  Warrants  and the
aggregate cash Exercise  Price thereof.  For purposes of this Section 2, "Market
Value" shall be an amount  equal to the average of the closing  sales price of a
share of Common Stock for the ten (10) days immediately  preceding the Company's
receipt  of the form of  notice of  exercise  duly  executed,  via  delivery  or
facsimile,  multiplied by the number of shares of Common Stock to be issued upon
exercise.  Upon  surrender of this  Certificate  and the notice of exercise form
duly  executed,  together  with payment of the Exercise  Price for the shares of
Common Stock  purchased,  the Company promptly shall send or cause to be sent to
the Holder a certificate or certificates representing the shares of Common Stock
purchased.  Upon the exercise of less than all of the Warrants evidenced by this
Certificate,  the  Company  promptly  shall  send to the  Holder  a new  Warrant
Certificate representing the unexercised portion of the Warrants.

         (b) The Warrants shall not be exercisable  until the Company shall have
filed with the State of Maryland  Department  of  Assessments  and Taxation (the
"Department")  an amendment of the Company's  charter  increasing  the number of
shares Common Stock

                                                         1

<PAGE>



that it is authorized to issue to at least 35 million shares. If the Company has
not filed such  amendment  with the  Department by April 30, 1998 (or such later
date as may be unanimously agreed by the parties to that certain Preferred Share
and  Warrant  Purchase  Agreement  dated as of December 4, 1997 by and among the
Company,  CAI  Advisors & Co. and Astero  Cephac S.A.  (the  "Agreement")),  the
Warrants and the Holder's rights hereunder shall terminate.

         3.  Reservation of Shares.  The Company agrees that at all times during
the period of exercise of these Warrants there shall be reserved for issuance at
least that number of shares of Common Stock  required to be issued upon exercise
of the Warrants (the "Warrant Shares").

         4.  Mutilation  or Loss of  Warrant.  Upon  receipt  by the  Company of
evidence  satisfactory  to it of the loss,  theft,  destruction or mutilation of
this  Warrant  Certificate,  and,  in the  case of loss,  theft or  destruction,
receipt  of  reasonably  satisfactory  indemnification,  and,  in  the  case  of
mutilation,  upon surrender and  cancellation of this  Certificate,  the Company
will  execute and deliver a new Warrant  Certificate  of like tenor and date and
any  such  lost,  stolen,  destroyed  or  mutilated  Warrant  Certificate  shall
thereupon become void.

         5. Rights of the Holder.  The Holder  shall not, by virtue  hereof,  be
entitled to any rights of a stockholder in the Company, either at law or equity,
and the rights of the Holder are  limited  to those  expressed  in this  Warrant
Certificate and are not enforceable against the Company except to the extent set
forth herein.

         6. Protection  Against  Dilution.  The number of shares of Common Stock
that the Holder is entitled to purchase  upon  exercise of the  Warrants and the
Exercise Price shall be subject to adjustment from time to time as follows:

                  (a)  Adjustment  for  Subdivision.  If the Company at any time
subdivides (by any stock split, stock dividend,  recapitalization  or otherwise)
the  outstanding  shares of Common  Stock into a greater  number of shares,  the
number of shares that the Holder is entitled  to purchase  upon  exercise of the
Warrants  shall be  proportionately  increased and the Exercise  Price in effect
immediately prior to such subdivision shall be proportionately  reduced,  and if
the Company at any time  combines  (by reverse  stock  split or  otherwise)  the
outstanding  shares of Common Stock into a smaller number of shares,  the number
of shares that the Holder is entitled to purchase  upon exercise of the Warrants
shall be proportionately  decreased and the Exercise Price in effect immediately
prior to such  combination  and the  number  of  shares  of  Common  Stock to be
received  by the  Holder  pursuant  to the  Warrants  shall  be  proportionately
increased.

                  (b) Adjustment for Reorganization. Any capital reorganization,
reclassification,  consolidation,  merger or sale of all or substantially all of
the Company's  assets with or into another  person or entity that is effected in
such a manner  that  holders of Common  Stock are  entitled  to receive  (either
directly  or upon  subsequent  liquidation)  stock,  securities  or assets  with
respect to or in exchange for Common Stock shall be

                                                         2

<PAGE>



referred  to herein as an "Organic  Change."  Prior to the  consummation  of any
Organic Change,  the Company shall make appropriate  lawful provisions to ensure
that the Holder  shall  thereafter  have the right to acquire and  receive  upon
exercise of the Warrants during the period  specified herein and upon payment of
the Exercise Price then in effect such shares of stock,  securities or assets as
the Holder would have  received in  connection  with such Organic  Change if the
Holder had exercised the Warrants immediately prior to such Organic Change.

         7. Transfer  Complies with  Securities  Act. The Warrants have not been
registered under the Securities Act of 1933, as amended,  (the "Securities Act")
and have been  issued to the  Holder for  investment  and not with a view to the
distribution of either the Warrants or the Warrant Shares.  Neither the Warrants
nor any of the Warrant Shares may be sold, transferred,  pledged or hypothecated
in the absence of an effective  registration  statement under the Securities Act
relating to such security or an opinion of counsel  reasonably  satisfactory  to
the Company that  registration  is not required under the  Securities  Act. Each
Certificate  for the Warrants and the Warrant  Shares shall  contain a legend on
the face thereof, in form and substance satisfactory to counsel for the Company,
setting forth the restrictions on transfer contained in this Section 7.

         8.  Notices.  Any notice or other  communication  required or permitted
hereunder  shall be in writing and shall be delivered  personally,  telegraphed,
telexed,  sent by facsimile  transmission  or sent by  certified,  registered or
express mail,  postage  pre-paid.  Any such notice shall be deemed given when so
delivered personally,  telegraphed,  telexed or sent by facsimile  transmission,
or, if mailed, two days after the date of deposit in the United States mails, as
follows:

                  If to the Company, to:

                           PharmaKinetics Laboratories, Inc.
                           302 West Fayette Street
                           Baltimore, MD 21201
                           Attention: James K. Leslie, President
                           Telephone:                (410) 385-4500
                           Facsimile:                (410) 385-1957

                  with a copy to:

                           Ober, Kaler, Grimes & Shriver
                           120 E. Baltimore Street
                           Baltimore, MD 21202
                           Attention: Melissa A. Warren, Esquire
                           Telephone:                (410) 347-7684
                           Facsimile:                (410) 547-0699




                                                         3

<PAGE>




                  If to Holder, to:

                           [Astero Cephac S.A.        ]
                           [c/o] CAI Advisors & Co.
                           767 Fifth Avenue, 5th Floor
                           New York, NY 10153
                           Attention:  Leslie B. Daniels
                           Telephone:                (212) 319-2525
                           Facsimile:                (212) 319-0232

                  with a copy to:

                           Dyer Ellis & Joseph PC
                           600 New Hampshire Ave., N.W.
                           Washington, DC 20037
                           Attn: Michael Joseph
                           Telephone:                (202) 944-3000
                           Facsimile:                (202) 944-3068

Any party may  designate  another  address  or person  for  receipt  of  notices
hereunder by notice given to the other parties in  accordance  with this Section
8.

         9.  Transfer.  The Holder shall not  transfer the Warrants  without the
prior  written  consent of the  Company  except to parties to whom the rights to
purchase the Shares (as that term is defined in the  Agreement)  or the Warrants
have been assigned pursuant to Section 1.1 of the Agreement.

         10 Governing Law.  This Warrant Certificate shall be governed by and 
construed in accordance with the laws of the state of Maryland.

         11. Supplements and Amendments.  This Warrant Certificate may be 
amended or supplemented only by an instrument in writing signed by the parties 
hereto.

         12.  Counterparts.  This  Warrant  Certificate  may be  executed in any
number of  counterparts  and each such  counterpart  shall for all  purposes  be
deemed to be an original,  and all such counterparts  shall together  constitute
one and the same instrument.


                                                         4

<PAGE>




                  IN WITNESS  WHEREOF,  the parties have  executed  this Warrant
certificate as of the day of December 1997.

                                            PHARMAKINETICS LABORATORIES, INC.


                                            By:
                                                     James K. Leslie
                                    President

                                            [HOLDER]


                                            By:
                                      Name:
                                     Title:

                                                         5

<PAGE>






                         NOTICE OF EXERCISE OF WARRANTS

         The  undersigned  hereby  irrevocably  elects to  exercise  the  right,
represented by the attached Common Stock Purchase Warrant  Certificate  dated as
of (the  "Certificate") to purchase shares of the Common Stock, par value $0.001
per share, of PharmaKinetics Laboratories,  Inc. and either (i) tenders herewith
payment in accordance with said Certificate or (ii) elects  "cashless  exercise"
in accordance with the Certificate, as indicated below.

         The undersigned  hereby confirms and acknowledges  that the undersigned
will not offer, sell or otherwise dispose of any shares of Common Stock received
upon  exercise of the  Warrants  except  pursuant to an  effective  registration
statement  under the  Securities Act of 1933, as amended,  and applicable  state
securities laws or pursuant to an exemption form registration in accordance with
such Act and laws.

         Please issue in the name of the undersigned a new Common Stock Purchase
Warrant  Certificate  representing  the  unexercised  portion  of  the  Warrants
represent by the attached Certificate.

         Please issue the stock  certificate(s)  in the names and  denominations
and deliver them to the addresses set forth below:







Dated:______________________


By:_________________________



|_|                        CASH:            $ _______________________

|_|               CASHLESS EXERCISE




<PAGE>



                                  SCHEDULE 5.3

                      FORM OF REGISTRATION RIGHTS AGREEMENT

         THIS REGISTRATION RIGHTS AGREEMENT is made and entered into on this day
of DECEMBER 1997, by and among PHARMAKINETICS  LABORATORIES,  INC. a corporation
organized under the laws of the state of Maryland (the "Company"),  CAI ADVISORS
& CO., a partnership  organized under the laws of Quebec,  Canada  ("CAI"),  and
ASTERo CEPHAC S.A., a company organized under the laws of France ("Aster") (CAI,
Aster and any  successors  and assigns  permitted  pursuant to Section 7(c) each
being  referred  to  herein  as  a   "Stockholder"   and   collectively  as  the
"Stockholders").

                                    RECITALS

         A. The  Company,  CAI and Aster are  parties to a  Preferred  Stock and
Warrant  Purchase  Agreement  dated December 4, 1997 (the "Purchase  Agreement")
pursuant to which CAI and Aster or their  assigns will  purchase an aggregate of
833,300 shares of PharmaKinetics Class A Convertible Preferred Stock convertible
into 8,333,000 shares of PharmaKinetics  Common Stock, par value $.001 per share
(the  "Shares")  and warrants to purchase an  aggregate  of 6,250,000  shares of
PharmaKinetics  Common  Stock  with an  exercise  price of $1.20 per share  (the
"Warrants").

         B. The  execution  of this  Agreement  is a condition  precedent to the
obligations  of CAI and Aster under the  Purchase  Agreement to  consummate  the
purchase of the Shares and the Warrants.

         NOW,  THEREFORE,  in  consideration  of the Purchase  Agreement and the
conditions and agreements hereinafter set forth, the parties agree as follows:

Section 1.                 DEMAND REGISTRATION RIGHTS

         (a) Request for  Registration.  A Stockholder or  Stockholders  holding
Shares,  Warrants,  Contingent  Warrants  and/or  Conversion  Shares that in the
aggregate  represent  at least  50% of the  Underlying  Shares  then held by the
Stockholders  shall have the right on two  occasions to request the Company,  in
writing, to effect the registration of Conversion Shares with the Securities and
Exchange  Commission (the "Commission")  pursuant to the Securities Act of 1933,
as amended (the "Securities Act"); provided,  however, that the Stockholders may
not demand registration on more than one occasion within the twelve-month period
following  the  Closing.  Such  written  request  shall  specify  the  number of
Conversion  Shares to be registered  and the intended  method of  disposition of
such Conversion Shares. For purposes of this Section 1(a),  "Underlying  Shares"
shall include the shares of Common Stock  underlying  the Shares,  the Warrants,
and the Contingent Warrants, as well as any Conversion Shares.

         (b)  Notice  to  Stockholders.  Upon  receipt  of the  written  request
referred to in Section 1(a),  the Company shall (i) within five days give notice
of the requested  registration to all other Stockholders  (including information
regarding the intended method of disposition of the Conversion Shares),  who may
then elect to participate in such

                                                         1

<PAGE>



registration  by giving the Company notice of such election within 20 days after
notice of the requested  registration is received, and (ii) use its best efforts
to  effect  the  registration  on Form S-3 (or  other  appropriate  form) of the
Conversion Shares for which the Stockholders have requested registration.

         (c) Limitation on Rights.  Notwithstanding any other provisions of this
Section 1, the Company shall not be obligated to register  Conversion  Shares if
(i) all of the  Conversion  Shares  for which the  Stockholders  have  requested
registration are eligible for sale pursuant to Rule 144 under the Securities Act
without  regard to the  volume  limitations  set  forth in Rule 144 and  Company
causes its agents  promptly to transfer shares eligible for sale under Rule 144,
or (ii) the  aggregate  proceeds  of the  offering of the  Conversion  Shares so
registered (after deduction of underwriting  discounts and selling  commissions)
will not exceed $150,000.

         Notwithstanding   any  other   provisions   of  this   Section  1,  the
Stockholders shall not demand registration of the Conversion Shares in the event
that the  Board of  Directors  of the  Company  has  approved  the  filing  of a
registration statement covering securities issued for the Company's account in a
firm commitment  underwritten  public offering and has notified the Stockholders
of such  proposed  filing,  beginning 60 days prior to the intended date of such
filing as set forth on such  notice  and  ending  upon the  earlier  of (i) such
intended filing date, if such registration statement has not then been filed, or
(ii) 60 days  following  the  effective  date  of such  registration  statement;
provided  that the Company is actively  employing  in good faith all  reasonable
efforts to cause such registration statement to become effective;  and provided,
further, that the Stockholders may include or could have included the Conversion
Shares in such registration statement pursuant to Section 2.

         Notwithstanding any other provisions of this Section 1, if, at the time
of any request to register  Conversion  Shares  pursuant to this  Section 1, the
Company is engaged or intends to engage in any acquisition, disposition, merger,
business  combination,   corporate  reorganization,   or  other  transaction  or
development  that has not been publicly  disclosed and which,  in the good faith
determination of the Company's Board of Directors,  would be adversely  affected
by the requested registration,  then the Board of Directors may direct that such
request be delayed until such  transaction or development is publicly  disclosed
or has been  abandoned,  but in any event for a period not to exceed 60 days. In
such event, the Stockholders shall be deemed to have withdrawn their request for
registration  and such request shall not be counted as a demand  registration to
which such Stockholders are entitled pursuant to this Section 1.

         The  Company  shall not be  entitled  to invoke its rights set forth in
this Section 1(c) more than one time in any 12-month period.

         (d) Underwriting. In the event the Stockholders requesting registration
intend to distribute  the  Conversion  Shares by means of an  underwriting,  the
right of any

                                                         2

<PAGE>



Stockholders to be included in such registration  shall be conditioned upon such
Stockholders'  agreement  to pay  their  pro  rata  share  of  the  underwriting
discounts and commissions.

         The Company and the  Stockholders  holding the Conversion  Shares to be
registered  shall  enter  into an  underwriting  agreement  with an  underwriter
selected  by the  Stockholders  and  approved by the Board of  Directors  of the
Company  (which  approval  shall not be  unreasonably  withheld)  requesting the
registration   under   Section   1(a).   Such   agreement   shall   contain  the
representations,  warranties,  and covenants and other terms as are  customarily
contained in  agreements of that type and shall be  reasonably  satisfactory  in
form and substance to Company and the Stockholders holding the Conversion Shares
being registered.

         Notwithstanding  any  other  provisions  of  this  Section  1,  if such
underwriter  advises the Company in writing  that  marketing  factors  require a
reduction  in the  number  of  Conversion  Shares to be  underwritten,  then the
Company shall so advise the  Stockholders  holding the  Conversion  Shares to be
registered,  and the  number  of  Conversion  Shares  that are  included  in the
registration statement shall be reduced in accordance with such requirements pro
rata among Stockholders in accordance with the number of Conversion Shares being
registered.  The written notification from such underwriter to the Company shall
include a reasonable basis for such underwriter's advice.

         The Company shall not include or permit the inclusion of any securities
other than the Conversion Shares in any registration statement filed pursuant to
the  provisions  of this  Section 1 without  the prior  written  consent  of the
holders of the Conversion Shares being registered.

Section 2.                 PIGGYBACK REGISTRATION RIGHTS

         (a) Request for  Registration.  If the Company proposes to register any
of its  securities  under the  Securities  Act on Form  S-1,  S-2 or S-3 (or any
equivalent  general  registration  form then in effect not  relating to employee
benefit plans or transactions covered by Rule 145 under the Securities Act), the
Company  shall:  (i) promptly give written notice of such  registration  to each
Stockholder,  and  (ii)  include  in such  registration  the  Conversion  Shares
specified in any written requests received from such Stockholders within 20 days
following delivery of such notice.

         (b) Limitation on Rights.  Notwithstanding any other provisions of this
Section  2, the  Company  shall  have the  right at any time  after it has given
notice of the filing of a  registration  pursuant to this Section 2 to elect not
to proceed with such registration.

         Notwithstanding  any other  provisions  of this  Section 2, the Company
shall not be obligated to register  Conversion  Shares if such Conversion Shares
are  eligible  for sale  pursuant to Rule 144 under the  Securities  Act without
regard to the volume limitations set forth in Rule 144.


                                                         3

<PAGE>



         Notwithstanding  any  other  provisions  of  this  Section  2,  if  the
Company's managing underwriter advises the Company in writing that the number of
Conversion Shares requested to be included in the registration statement exceeds
the number of such  Conversion  Shares that can be sold in an orderly  manner in
the offering or that the  inclusion of such  Conversion  Shares would  adversely
affect the  offering,  then the Company  shall be required to include  only that
number of  Conversion  Shares  that  would not exceed  such  number or have such
adverse effect.  The written  notification  from such underwriter to the Company
shall include a reasonable  basis for such  underwriter's  advice.  In the event
that it is necessary to reduce the number of Conversion Shares to be included in
the  registration  statement,  such  reduction  shall  be made  pro  rata  among
Stockholders  in  accordance   with  the  number  of  Conversion   Shares  being
registered. Notwithstanding the other provisions of this Section 2, no reduction
in the number of Conversion Shares being registered shall be effected unless the
Conversion Shares represent the only securities held by any selling shareholders
covered by the registration  statement. To the extent that following the date of
this  Agreement the Company grants rights to any person or entity to participate
in any  registration  statement,  the agreement  setting forth such rights shall
provide that such rights shall in all respects be  subordinate to the rights set
forth in this Agreement.

Section 3.                 INFORMATION PROVIDED BY STOCKHOLDERS

         Any   Stockholder   whose   Conversion   Shares  are  included  in  any
registration  statement  hereunder shall furnish to the Company such information
regarding  such  Stockholder  and the  intended  method of  distribution  of the
Conversion Shares as the Company may request in writing.

Section 4.                  EXPENSES OF REGISTRATION

         All fees and expenses in connection  with any  registration  hereunder,
including  registration fees, printing expenses,  blue sky fees and expenses and
the  Company's  legal and  accounting  fees and  expenses  shall be borne by the
Company.  Underwriting  discounts and selling commissions and legal counsel fees
shall be borne by the  Stockholders  pro rata in  accordance  with the number of
Conversion Shares being registered.

Section 5.                 REGISTRATION PROCEDURES

         Whenever  the Company  shall be required  to  register  any  Conversion
Shares hereunder, the Company shall, as expeditiously as possible:

         (a)  Filings.  Prepare and file with the  Commission,  and use its best
efforts to cause to be declared and remain  continuously  effective for a period
of time not exceeding 120 days,  the  registration  statement and any amendments
and supplements  thereto and the prospectus used in connection  therewith as may
be necessary to keep the registration  statement  current and to comply with the
provisions of the Securities  Act with respect to the  disposition of Conversion
Shares covered by the registration statement.

                                                         4

<PAGE>



Notwithstanding  the other  provisions  of this Section  5(a),  in the event the
registration  statement  is filed on Form S-3 (or a successor  form that permits
incorporation  by  reference),  the Company  shall use its best efforts to cause
such  registration  statement to remain  continuously  effective for a period of
time not  exceeding  two  years;  provided,  however,  that the rules  under the
Securities  Act  permitting  the   incorporation  by  reference  of  information
contained in periodic  reports filed under the Securities  Exchange Act of 1934,
as amended,  are not repealed or amended in a manner so as to  materially  limit
the amount of such  information that may be so incorporated by reference and the
rules under the Securities  Act  permitting  offerings on a continued or delayed
basis are not repealed.

         (b) Copies of Documents.  Furnish to each Stockholder  participating in
the offering and each underwriter,  if any, copies of the registration statement
and each amendment and supplement thereto and copies of the prospectus  included
therein  (including each summary,  preliminary,  final,  amended or supplemented
prospectus) in conformity with the requirements of the Securities Act and copies
of such other documents as each such Stockholder and underwriters, if any, shall
reasonably  require in order to facilitate  the  disposition  of the  Conversion
Shares,  but only while the Company is required under the  provisions  hereof to
keep the registration statement current.

         (c) Blue Sky  Compliance.  Use its best  efforts to register or qualify
the Conversion  Shares covered by the  registration  statement  under such other
securities  or blue sky laws of such  jurisdictions  in the United States as the
Company or the managing  underwriter,  if any, determine is reasonably necessary
to enable each  participating  Stockholder to consummate the  disposition of the
Conversion Shares owned by it in compliance with the laws of such  jurisdiction;
provided,  however,  that the Company shall not be required to subject itself to
any suit (other than suits arising in connection with the sale of the Conversion
Shares) in any jurisdiction where it has not theretofore done so.

         (d) Experts. Furnish to each underwriter  participating in the offering
(i) an  opinion  of  counsel to the  Company  dated the  effective  date of such
registration  statement  and the  date of the  closing  under  the  underwriting
agreement,  and (ii) a "cold  comfort"  letter dated the effective  date of such
registration  statement  and the  date of the  closing  under  the  underwriting
agreement signed by the independent  public accountants who have issued a report
on the Company's financial  statements included in such registration  statement,
in each case covering the matters agreed upon by the parties to the underwriting
agreement.

         (e)  Material  Information.  Immediately  (i) notify  each  Stockholder
participating in the offering and the managing underwriter, if any, of any event
that results in the prospectus included in the registration  statement,  as then
in effect,  including  any untrue  statement  of a material  fact or omitting to
state any material fact  required to be stated  therein or necessary to make the
statements  therein,  in the  light  of the  circumstances  then  existing,  not
misleading,  and (ii) amend or supplant  such  prospectus as may be necessary so
that such prospectus  shall not include any untrue  statement of a material fact
or omit to state any material fact required to be stated therein or necessary to
make the

                                                         5

<PAGE>



statements therein, in light of the circumstances then existing, not misleading,
and so that such prospectus will comply with applicable law.

         (f) Other Compliance With Law. Otherwise use its best efforts to comply
with all applicable rules and regulations of the Commission.

         (g)  Transfer  Agent  and  Registrar.  Provide  a  transfer  agent  and
registrar (which may be the same entity) for the Conversion Shares.

Section 6.                 INDEMNIFICATION

         (a) The Company will indemnify each Stockholder whose Conversion Shares
are included in any registration hereunder and each of its officers,  directors,
and partners and each person controlling such Stockholders within the meaning of
Section 15 of the Securities Act, and each underwriter,  if any, and each of its
officers,  directors and partners,  and each person who controls any underwriter
within the meaning of Section 15 of the  Securities  Act,  against all expenses,
claims,  losses,  damages  and  liabilities  (and  actions  in  respect  thereof
commenced or  threatened),  arising out of or based on any untrue  statement (or
alleged  untrue  statement)  of a material  fact  contained in any  registration
statement or prospectus, or any amendment or supplement thereto, incident to any
such  registration,  or based on any  omission  (or alleged  omission)  to state
therein a material fact  required to be stated  therein or necessary to make the
statements  therein,  in light of the circumstances in which they were made, not
misleading,  or  any  violation  by  the  Company  of  any  rule  or  regulation
promulgated  under  the  Securities  Act  applicable  to the  Company  and  will
reimburse each such Stockholder,  each of its officers, directors, and partners,
and each person controlling such Stockholder, each such underwriter, each of its
officers,  directors,  and  partners  and  each  person  who  controls  any such
underwriter,  for any legal expenses and any other expenses  reasonably incurred
in connection with  investigating,  preparing or defending any such claim, loss,
damage,  liability,  or action,  provided that the Company will not be liable in
any such case to the extent that any such claim,  loss,  damage,  liability,  or
expense arises out of or is based on any untrue statement or omission or alleged
untrue  statement  or omission,  made in reliance  upon and in  conformity  with
information  furnished to the Company by such Stockholder or underwriter for use
therein.  The indemnity agreement contained in this Section 6(a) shall not apply
to amounts paid in settlement of any such loss,  claim,  damage,  liability,  or
action if such settlement is effected  without the consent of the Company (which
consent has not been unreasonably withheld).

         (b) Each  Stockholder  whose  Conversion  Shares are  included  in such
registration will indemnify the Company, and each of its directors and officers,
each underwriter, if any, and each of its officers, directors, and partners, and
each person who controls the Company or such  underwriter  within the meaning of
Section 15 of the  Securities  Act,  against  all  claims,  losses,  damages and
liabilities (and actions in respect thereof commenced or threatened) arising out
of or based on any untrue statement (or alleged untrue  statement) of a material
fact  contained  in  any  such  registration  statement  or  prospectus,  or any
amendment or supplement thereto, incident to any such registration,

                                                         6

<PAGE>



or any omission (or alleged  omission) to state therein a material fact required
to be stated therein or necessary to make the statement  therein not misleading,
and will  reimburse  the Company  and such  underwriters,  directors,  officers,
partners,  or control  persons  for any legal  expenses  for any other  expenses
reasonably  incurred in  connection  with  investigation  or defending  any such
claim, loss, damage,  liability, or action, in each case to the extent that such
untrue statement (or alleged untrue statement) or omission (or alleged omission)
resulted  from  the  Company's  reliance  upon  information  furnished  by  such
Stockholder.  The indemnity  agreement  contained in this Section 6(b) shall not
apply to amounts paid in settlement of any such loss, claim, damage,  liability,
or action  if such  settlement  is  effected  without  the  consent  of the each
Stockholder (which consent has not been unreasonably withheld).

         (d) Each party  entitled to  indemnification  under this Section 6 (the
"Indemnified  Party")  shall  give  notice  to the  party  required  to  provide
indemnification (the "Indemnifying  Party") promptly after the Indemnified Party
has actual  knowledge of any claim as to which indemnity may be sought and shall
permit  the  Indemnifying  Party to  assume  the  defense  of such  claim or any
litigation resulting therefrom provided that counsel for the Indemnifying Party,
who  shall  conduct  the  defense  of such  claim  or any  litigation  resulting
therefrom shall be approved by the  Indemnified  Party (whose approval shall not
be unreasonably  withheld),  and the  Indemnified  Party may participate in such
defense at such party's  expense,  and provided  further that the failure of any
Indemnified  Party to give  notice as  provided  herein  shall not  relieve  the
Indemnifying  Party of its obligations  under this Section 6, to the extent such
failure is not  prejudicial.  No  Indemnifying  Party in the defense of any such
claim or litigation,  shall,  except with the consent of each Indemnified Party,
consent to the entry of any judgment or enter into any settlement  that does not
include as an unconditional term thereof the giving by the claimant or plaintiff
to such  Indemnified  Party of a release  from all  liability in respect to such
claim or  litigation.  Each  Indemnified  Party shall  furnish such  information
regarding  itself  or  the  claim  in  question  as an  Indemnifying  Party  may
reasonably request in writing as shall be reasonably required in connection with
the defense of such claim and litigation resulting therefrom.

         (d) To the  extent  any  indemnification  by an  indemnifying  party is
prohibited or limited by law, the indemnifying  party agrees to make the maximum
contribution  with respect to any amounts for which it would otherwise be liable
under this Section 6 to the fullest extent permitted by law; provided,  however,
that  contribution  by any seller of the  Conversion  Shares shall be limited in
amount to the net amount of  proceeds  received  by such seller from the sale of
such Conversion Shares.

         Section 7.                 GENERAL

                  (a)  Defined Terms.   Capitalized terms not defined herein 
shall have the meanings attributed to them in the Purchase Agreement.

                  (b)  Notices.  Any notice or other  communication  required or
which may be given  hereunder  shall be in  writing  and shall be deemed to have
been  duly  given on the  date  delivered  if  delivered  personally  or sent by
facsimile to the persons identified below,

                                                         7

<PAGE>



one business day following deposit with a reputable  overnight courier, or three
business  days  after  deposit  in the  U.S.  mail if  mailed  by  certified  or
registered mail, return receipt requested, addressed as follows:



                  If to the Company, to:

                           PharmaKinetics Laboratories, Inc.
                           302 West Fayette Street
                           Baltimore, MD 21201
                           Attention: James K. Leslie, President
                           Telephone:                (410) 385-4500
                           Facsimile:                (410) 385-1957

                  with a copy to:

                           Ober, Kaler, Grimes & Shriver
                           120 E. Baltimore Street
                           Baltimore, MD 21202
                           Attention: Melissa A. Warren, Esquire
                           Telephone:                (410) 347-7684
                           Facsimile:                (410) 547-0699

                  If either Stockholder, to:

                           CAI Advisors & Co.
                           767 Fifth Avenue, 5th Floor
                           New York, NY 10153
                           Attention:  Leslie B. Daniels
                           Telephone:                (212) 319-2525
                           Facsimile:                (212) 319-0232

                  with a copy to:

                           Dyer Ellis & Joseph PC
                           600 New Hampshire Ave., N.W.
                           Washington, DC 20037
                           Attn: Michael Joseph
                           Telephone:                (202) 944-3000
                           Facsimile:                (202) 944-3068

Any party may change its address to which notices or other communications are to
be sent by giving  written  notice of any such  change  in the  manner  provided
herein for giving notice.


                                                         8

<PAGE>



                  (c) Assignment.  The Stockholders'  rights to have the Company
register the Conversion Shares pursuant to this Agreement automatically shall be
assigned to any party to whom the rights to purchase the Shares and the Warrants
have been assigned pursuant to Section 1.1 of the Purchase Agreement if: (a) the
Company is, within a reasonable time after such transfer, furnished with written
notice of (i) the name and address of such  transferee and (ii) a description of
the securities transferred.

                  (d) Lockup  Agreement.  If  requested  by the  Company and its
underwriter in connection with the registration of Conversion Shares in a firmly
underwritten public offering,  each holder of Conversion Shares being registered
shall agree not to sell,  transfer or otherwise dispose of any Conversion Shares
or other  securities  of the Company held by such holder (other than those being
registered)  for a  period  following  the  effective  date of the  registration
statement identified by the Company and such underwriter not to exceed 60 days.

                  (e)  Entire  Agreement.  This  Agreement  embodies  the entire
agreement and  understanding  between the parties hereto relating to the subject
matter  hereof and  supersedes  any prior  letters of  intent,  agreements,  and
understandings relating to the subject matter hereof.

                  (f)  Modification  or Waiver.  This  Agreement may be amended,
modified,  or  superseded  at any time by a written  instrument  executed by the
Company and each Stockholder, and any of the terms, covenants,  representations,
warranties,  or  conditions  hereof  may be waived by the party  intended  to be
benefited hereby.  No waiver of any nature, in any one or more instances,  shall
be deemed to be or construed as a further or continued  waiver of any  condition
or any breach of any other term, representation, or warranty in this Agreement.

                  (g)  Counterparts.  Separate  copies of this  Agreement may be
signed by the parties hereto,  with the same effect as though all of the parties
had signed one copy of this Agreement.

                  (h) Severability.  If any provision of this Agreement shall be
held invalid  under any  applicable  law, such  invalidity  shall not affect any
other  provision of this  Agreement that can be given effect without the invalid
provision and, to this end, the provisions hereof are severable.

                  (i)  Governing  Law. This  Agreement  shall be governed by and
construed in accordance with the laws of the state of Maryland.



                                                         9

<PAGE>


         IN  WITNESS  WHEREOF,   the  undersigned  parties  have  executed  this
Agreement as of the date first above written.

                                            PHARMAKINETICS LABORATORIES, INC.


                                            By:
                                                     James K. Leslie
                                    President

                                            CAI ADVISORS & CO.



                                            By:
                                                     Leslie B. Daniels
                                     Partner

                                            ASTERo CEPHAC S.A.


                                            By:
                                                     John J. Thebault
                                              Chief Executive and President

                                                        10



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission