PHARMAKINETICS LABORATORIES INC
SC 13D/A, 1998-01-09
TESTING LABORATORIES
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                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549

                                SCHEDULE 13D

                  Under the Securities Exchange Act of 1934
                              (Amendment No. 2)

                      PharmaKinetics Laboratories, Inc.
- --------------------------------------------------------------------------------

                             (Name of Issuer)

                  Common Stock, Par Value $0.001 Per Share

- --------------------------------------------------------------------------------

                    (Title of Class of Securities)

                              717131 10 6
                     -----------------------------

                            (CUSIP Number)

                           Leslie B. Daniels
                          CAI Advisors & Co.
                      767 Fifth Avenue, 5th Floor
                          New York, NY 10153
                            (212) 319-2525
- --------------------------------------------------------------------------------

 (Name, Address and Telephone Number of Persons Authorized to Receive Notices
                          and Communications)

                           December 23, 1997
                    ----------------------------

         (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Check the following box if a fee is being paid with this statement.| | (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be 
sent.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                                                         1

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         CAI Advisors & Co.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a) X
                                                                     (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           n\a
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                                  |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
           Quebec, Canada
                                                           7 SOLE VOTING POWER
                                                             0
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      0**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         0**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         0%**
     14  TYPE OF REPORTING PERSON*
         PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         2

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aster-Cephac S.A.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a) X
                                                                     (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          n\a
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                  |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         France
                                                           7 SOLE VOTING POWER
                                                             0
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      0**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         0**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                 |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         0%**
     14  TYPE OF REPORTING PERSON*
         CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         3

<PAGE>





                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Aster S.A.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           WC
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                                    |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
           France
                                                           7 SOLE VOTING POWER
                                                             2,916,600
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      2,916,600**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,916,600**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                 |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         13.5%**
     14  TYPE OF REPORTING PERSON*
         CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         4

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Leslie B. Daniels
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          PF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                   |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
                                                           7 SOLE VOTING POWER
                                                             1,818,016
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      1,818,016**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,818,016**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                 |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         8.4% **
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         5

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Richard J. Schmeelk
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           PF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                                    |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
          United States
                                                           7 SOLE VOTING POWER
                                                             1,818,016
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      1,818,016**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,818,016**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                  |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         8.4%**
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         6

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Peter M. Gottsegen
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          PF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                   |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
                                                           7 SOLE VOTING POWER
                                                             1,818,016
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      1,818,016**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,818.016**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                  |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         8.4%**
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"


                                                         7

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Peter G. Restler
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           AF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                                     |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
           United States
                                                           7 SOLE VOTING POWER
                                                             437,490
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      437,490**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         437,490**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                   |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         2.0%**
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         8

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         GES Investments S.A.
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          WC
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                    |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         Belgium
                                                           7 SOLE VOTING POWER
                                                             291,660
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      291,660**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         291,660**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                  |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         1.3%**
     14  TYPE OF REPORTING PERSON*
         CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                         9

<PAGE>





                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         David von Kauffmann
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
           PF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                                 |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
           France
                                                           7 SOLE VOTING POWER
                                                             291,660
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      291,660**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         291,660**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                   |_|
         PERCENT OF CLASS REPRESENTED
     13  BY AMOUNT IN ROW (11)
         1.3%**
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                        10

<PAGE>



                                  SCHEDULE 13D

CUSIP No. 717131 10 6


      1  NAME OF REPORTING PERSON
         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Manfred Yu
      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*             (a) X
                                                                       (b) |_|
      3  SEC USE ONLY
      4  SOURCE OF FUNDS*
          PF
      5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                  |_|
      6  CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
                                                           7 SOLE VOTING POWER
                                                             87,490
                      NUMBER OF
                       SHARES
                    BENEFICIALLY
                    OWNED BY EACH
                     REPORTING
                    PERSON WITH

                                                   8  SHARED VOTING POWER
                                                      0
                                                   9  SOLE DISPOSITIVE POWER
                                                      87,490**
                                                  10  SHARED DISPOSITIVE POWER
                                                      0**
     11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         87,490**
     12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                               |_|
     13  PERCENT OF CLASS REPRESENTED
         BY AMOUNT IN ROW (11)
         0.4%**
     14  TYPE OF REPORTING PERSON*
         IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                  **SEE DESCRIPTION PRESENTED UNDER THE CAPTION
                 "ITEM 5. INTEREST IN SECURITIES OF THE ISSUER"

                                                        11

<PAGE>





Item 1.  Security and Issuer.

         This  Statement  relates to 9,478,948  shares of the common stock,  par
value $0.001 per share (the "Common  Stock"),  of  PharmaKinetics  Laboratories,
Inc., a Maryland corporation (the "Company").  The Company's principal executive
offices are located at 302 West Fayette Street, Baltimore, Maryland 21201.

Item 2. Identity and Background.

         CAI  Advisors & Co.  ("CAI")  and  Aster-Cephac  S.A.  ("Aster-Cephac")
(together,  the  "Original  Reporting  Persons")  filed  the  Schedule  13D (the
"Schedule  13D") on November 13, 1997 and filed  Amendment No. 1 to the Schedule
13D ("Amendment No. 1") on December 15, 1997. The information required by Item 2
as to the  Original  Reporting  Persons is included in the  Schedule  13D.  This
Amendment No. 2 to the Schedule 13D is filed by the Original  Reporting  Persons
together with Leslie B. Daniels ("Daniels"),  Richard J. Schmeelk  ("Schmeelk"),
Peter M. Gottsegen ("Gottsegen"),  Peter G. Restler ("Restler"), GES Investments
S.A. ("GES"), David von Kauffmann  ("Kauffmann"),  and Manfred Yu ("Yu") (Aster,
Daniels, Schmeelk, Gottsegen, Restler, GES, Kauffmann, and Yu, collectively, the
"Assignees," and the Original Reporting Persons and the Assignees, collectively,
the  "Reporting  Persons") to reflect the  assignment  of rights to purchase the
securities of the Company, as described in Item 4 of this Amendment No. 2.

         Aster is a French  corporation  and is  wholly  owned by  Aster-Cephac,
which is in turn controlled by CAI. Aster's principal  executive offices located
at 3 et 5 rue Eugene Millon,  75015 Paris,  France. Aster is a contract research
organization  serving  the  pharmaceutical  industry.  A list  of the  executive
officers and directors of Aster is attached as Schedule 1.

         Daniels is a citizen of the United  States whose  business  address is:
CAI Advisors & Co., 767 Fifth  Avenue,  5th Floor,  New York,  New York,  10153.
Daniels is a managing partner of CAI.

         Schmeelk is an individual  citizen of the United States whose  business
address is: CAI Advisors & Co., 767 Fifth Avenue, 5th Floor, New York, New York,
10153. Schmeelk is a managing partner of CAI.

         Gottsegen is a citizen of the United States whose business  address is:
CAI Advisors & Co., 767 Fifth  Avenue,  5th Floor,  New York,  New York,  10153.
Gottsegen is a managing partner of CAI.

         Restler is a citizen of the United States whose business address is CAI
Advisors & Co., 767 Fifth Avenue, 5th Floor, New York, New York, 10153.  Restler
is a managing partner of CAI.

         GES is a Belgian  corporation,  affiliated with Aster and Aster-Cephac,
having its  principal  executive  offices at Avenue  Delleur 18, 1170  Brussels,
Belgium.  GES is an investment fund making investments in the pharmaceutical and
related industries.  The sole director and President of GES is Mr. Jean Jacques,
a French  citizen  whose  business  address for purposes of GES is: 13 Avenue de
Mercure1180 Uccle, Belgium.

         Kauffmann is a citizen of France whose business address is: CAI Capital
Corporation, 46 rue Paul Valery, 75016 Paris, France. Kauffmann is a director of
Aster-Cephac and Aster.


                                                        12

<PAGE>



         Yu is a citizen of the United  States  whose  business  address is: CAI
Advisors & Co., 767 Fifth Avenue,  5th Floor, New York, New York, 10153. Yu is a
partner of CAI.

         During  the last five  years,  no  Reporting  Person  nor any  partner,
executive  officer or director of any Reporting  Person, to the knowledge of any
Reporting Person, has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors) or has been a party to a civil proceeding of
a judicial or administrative  body of competent  jurisdiction and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

         The information with respect to a particular Reporting Person contained
in this Amendment No. 2 is given solely by such  Reporting  Person and the other
Reporting  Persons have no  responsibility  for the accuracy or  completeness of
information supplied by such Reporting Person.

Item 3. Source and Amount of Funds or Other Consideration.

         The source of funds used to purchase  the  securities  will  consist of
working  capital or personal  funds of the  Reporting  Persons,  except that the
source of funds used by Restler to purchase the  securities  is loans of $50,000
made by each of Daniels, Schmeelk, and Gottsegen for the purpose of funding such
a purchase.  The aggregate  amount of funds  required to purchase the Shares and
Warrants (as those terms are defined in Item 4) being  acquired by the Reporting
Persons is  $3,249,999.  The  aggregate  exercise  price of the  Warrants  being
acquired by the Reporting Persons is $4,874,997.60.

Item 4. Purpose of Transaction.

         The  purpose of the  acquisition  of  securities  of the Company by the
Reporting  Persons is for investment  and to facilitate a strategic  partnership
between  Aster-Cephac  and the  Company.  Except as discussed in this Item 4, no
Reporting  Person  currently  has any plan or proposal that relates to, or would
result  in,  any of the  actions  enumerated  in Item 4 of the  instructions  to
Schedule 13D.

         On December 4, 1997, CAI, Aster-Cephac, which is controlled by CAI, and
the Company entered into a Preferred Share and Warrant Purchase  Agreement (such
agreement,  along with the schedules thereto, the "Purchase Agreement") pursuant
to which CAI and Aster-Cephac  agreed to purchase an aggregate of 833,300 shares
of the Company's Class A Convertible  Preferred Stock convertible into 8,333,000
shares of Common Stock (the  "Shares")  and warrants to purchase an aggregate of
6,250,000  shares of Common  Stock at an exercise  price of $1.20 per share (the
"Warrants"). Under the Purchase Agreement, CAI was obligated to purchase 666,640
Shares  and  Warrants  to  purchase   5,000,000  shares  of  Common  Stock,  and
Aster-Cephac  was obligated to purchase  166,660 Shares and Warrants to purchase
1,250,000  shares  of Common  Stock.  The terms of the  Purchase  Agreement  are
described under Item No. 4 of Amendment No. 1.

         Pursuant to the terms of the Purchase  Agreement,  CAI and Aster-Cephac
assigned  their rights to purchase the Shares and the Warrants to the  Assignees
and  to  certain  other  entities  and  individuals  not  affiliated  with  CAI,
Aster-Cephac or the Assignees.  The Reporting  Persons are filing this Amendment
No. 2 to reflect the assignment of such rights.  The assignment  agreements (the
"Assignment  Agreements") pursuant to which CAI and Aster-Cephac,  respectively,
assigned their rights under the Purchase Agreement are filed as exhibits to this
Amendment No. 2.





                                                        13

<PAGE>



Item 5. Interest in Securities of the Company.

         In  accordance  with Rules  13d-3(d)(1)(i)  and  13d-5(b)(1)  under the
Securities  Act of 1933,  as  amended,  the  Reporting  Persons may be deemed to
beneficially   own  an  aggregate  of  9,478,948  shares  of  Common  Stock,  or
approximately  43.7% of the Company's  outstanding  Common Stock.  The Reporting
Persons  have the  right  to  acquire  5,416,450  shares  of  Common  Stock,  or
approximately 25.0% of the Company's  outstanding Common Stock, based upon their
ownership  of the Shares,  and the right to acquire  4,062,498  shares of Common
Stock, or approximately  18.7% of the Company's  outstanding Common Stock, based
upon their ownership of the Warrants.

         Having  assigned their rights to acquire  Shares and Warrants,  CAI and
Aster-Cephac  will not have  voting or  dispositive  power  with  respect to any
shares of Common Stock.  Aster will have sole voting and dispositive  power with
respect to  2,916,600  shares of Common  Stock,  or  approximately  13.5% of the
Company's   outstanding  Common  Stock.   Daniels  will  have  sole  voting  and
dispositive  power  with  respect  to  1,818,016  shares  of  Common  Stock,  or
approximately 8.4% of the Company's outstanding Common Stock. Schmeelk will have
sole voting and  dispositive  power with respect to  1,818,016  shares of Common
Stock,  or  approximately  8.4%  of  the  Company's  outstanding  Common  Stock.
Gottsegen will have sole voting and dispositive  power with respect to 1,818,016
shares of Common  Stock,  or  approximately  8.4% of the  Company's  outstanding
Common Stock.  Restler will have sole voting and dispositive  power with respect
to  437,490  shares of Common  Stock,  or  approximately  2.0% of the  Company's
outstanding  Common Stock. GES will have sole voting and dispositive  power with
respect  to  291,660  shares  of  Common  Stock,  or  approximately  1.3% of the
Company's  outstanding  Common  Stock.  Kauffmann  will  have  sole  voting  and
dispositive   power  with  respect  to  291,660  shares  of  Common  Stock,   or
approximately 1.3% of the Company's  outstanding Common Stock. Yu will have sole
voting and  dispositive  power with respect to 87,490 shares of Common Stock, or
approximately 0.4% of the Company's outstanding Common Stock.

         No Reporting Person nor any partner,  executive  officer or director of
any Reporting Person,  to the knowledge of any Reporting  Person,  had purchased
any of the Company's securities during the past sixty days.

tem 6. Contracts, Arrangements, Understandings or Relationships with Respect to 
Securities of the Company.

         None except as disclosed in Item 4.

Item 7. Material to be Filed as Exhibits.

         The Assignment Agreements and a Joint Filing Agreement are filed as 
exhibits to this Amendment No. 2.


                                   SIGNATURES

         After  reasonable  inquiry and to the best of his knowledge and belief,
the  undersigned  certifies that the  information set forth in this Statement is
true, complete and correct.

Date: January 8, 1998

                                      /s/ LESLIE B. DANIELS
                                          Leslie B. Daniels

                                                        14

<PAGE>


                                   SCHEDULE 1


                 DIRECTORS AND EXECUTIVE OFFICERS OF ASTER S.A.


NAME                              ADDRESS                          CITIZENSHIP

Mr. Jean Jacques Thebault         Aster o  Cephac                  French
                                  3 et 5 rue Eugene Millon
                                  75015 Paris France

Mr. David von Kauffmann           CAI Capital Corporation          French
                                  46 rue Paul Valery
                                  75016 Paris France

Ms. Sylvie Baudet Plazolles       Aster o  Cephac                  French
                                  3 et 5 rue Eugene Millon
                                  75015 Paris France



                                                        15



                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT  is made and entered  into as of the day of
December  1997 by and among ASTERo  CEPHAC S.A., a company  organized  under the
laws of France  ("Assignor"),  ASTER S.A., a company organized under the laws of
France ("Assignee"), and PharmaKinetics Laboratories,  Inc., a company organized
under the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,   Assignor,   PharmaKinetics,   and  CAI  Advisors  &  Co.,  a
partnership organized under the laws of Quebec, Canada ("CAI"), are parties to a
Preferred  Share and  Warrant  Purchase  Agreement  dated  December 4, 1997 (the
"Purchase  Agreement") and a Registration Rights Agreement dated December , 1997
(the "Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS, Assignee is a wholly owned subsidiary of Assignor;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for its own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred pursuant to Rule 144 under the Securities

                                                         1

<PAGE>



Act, all certificates representing all Shares, Warrants,  Contingent Warrants or
Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or its  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee, by itself or through its representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
it fully  capable of  evaluating  the merits  and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of its investment and
can afford a complete loss of its investment.

         (d)  Assignee  has full  power  and  authority  to make  the  foregoing
representations and to enter into this Assignment and to perform the obligations
contemplated  under the  Purchase  Agreement  in  accordance  with their  terms.
Assignee is a duly organized and validly existing company in good standing under
the laws of France. Assignee has obtained each required authorization,  consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) its
purchase of Shares,  Warrants and Contingent Warrants, and (iii) its performance
of its obligations  under this Assignment and the obligations under the Purchase
Agreement that it is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.


                                                         2

<PAGE>



         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required corporate action, and as of the Closing, will be
duly executed and delivered,  and will  constitute the legal,  valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict with any term or provision of any of Assignor's charter  documents,  or
any  other  instrument,   law,  statute,   rule  or  regulation;   and  (iv)  no
authorization,  consent,  or approval of, or filing or  registration  with,  any
court or governmental  department,  commission,  or agency,  whether domestic or
foreign,  is or will be necessary in connection  with the execution and delivery
by Assignor of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                   ASTERo CEPHAC S.A.


                                   By: /s/ JOHN J. THEBAULT
                                         John J. Thebault
                                    Chief Executive and President


                                   ASTER S.A.


                                   By:  /s/ JOHN J. THEBAULT
                                            John J. Thebault
                                            President


                                   PHARMAKINETICS LABORATORIES, INC.


                                   By: /s/ JAMES K. LESLIE
                                           James K. Leslie
                                             President

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec, Canada ("Assignor"), DAVID KAUFFMANN, an individual resident
in  France  ("Assignee"),  and  PharmaKinetics  Laboratories,  Inc.,  a  company
organized under the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing  all Shares,  Warrants,  Contingent  Warrants or Conversion  Shares
acquired by Assignee shall bear a legend reading substantially as follows:


                                                         1

<PAGE>



The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict  with  any  term  or  provision  of  any of  Assignor's  organizational
documents, or any other instrument,  law, statute, rule or regulation;  and (iv)
no authorization, consent, or approval

                                                         2

<PAGE>


of, or filing  or  registration  with,  any  court or  governmental  department,
commission,  or agency,  whether domestic or foreign, is or will be necessary in
connection  with the  execution  and  delivery by  Assignor  of this  Assignment
Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                    CAI ADVISORS & CO.


                                    By: /s/ LESLIE B. DANIELS
                                             Leslie B. Daniels
                                             Partner


                                    PHARMAKINETICS LABORATORIES, INC.


                                    By: /s/ JAMES K. LESLIE
                                             James K. Leslie
                                             President




                                    /s/ DAVID KAUFFMANN
                                    DAVID KAUFFMANN

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT  is made and entered  into as of the day of
December 1997 by and among CAI ADVISORS & CO., a partnership organized under the
laws of Quebec,  Canada  ("Assignor"),  INITIATIVE & FINANCE  INVESTISSEMENT,  a
company  organized  under the laws of France  ("Assignee"),  and  PharmaKinetics
Laboratories,   Inc.,   a  company   organized   under  the  laws  of   Maryland
("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France, are parties to a Preferred Share and Warrant
Purchase  Agreement  dated  December 4, 1997 (the  "Purchase  Agreement")  and a
Registration Rights Agreement dated December 19, 1997 (the "Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for its own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or its  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee, by itself or through its representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
it fully  capable of  evaluating  the merits  and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of its investment and
can afford a complete loss of its investment.

         (d)  Assignee  has full  power  and  authority  to make  the  foregoing
representations and to enter into this Assignment and to perform the obligations
contemplated  under the  Purchase  Agreement  in  accordance  with their  terms.
Assignee is a duly organized and validly existing company in good standing under
the laws of France. Assignee has obtained each required authorization,  consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) its
purchase of Shares,  Warrants and Contingent Warrants, and (iii) its performance
of its obligations  under this Assignment and the obligations under the Purchase
Agreement that it is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.


                                                         2

<PAGE>



         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required corporate action, and as of the Closing, will be
duly executed and delivered,  and will  constitute the legal,  valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict with any term or provision of any of Assignor's charter  documents,  or
any  other  instrument,   law,  statute,   rule  or  regulation;   and  (iv)  no
authorization,  consent,  or approval of, or filing or  registration  with,  any
court or governmental  department,  commission,  or agency,  whether domestic or
foreign,  is or will be necessary in connection  with the execution and delivery
by Assignor of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                    CAI ADVISORS & CO.


                                    By: /s/ LESLIE DANIELS
                                             Leslie Daniels
                                             Partner


                                    INITIATIVE & FINANCE INVESTISSEMENT


                                    By: /s/ JEROME METZ
                                             Name: Jerome Metz
                                             Title:  President


                                    PHARMAKINETICS LABORATORIES, INC.


                                    By: /s/ JAMES K. LESLIE
                                             James K. Leslie
                                             President

                                                         3






                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec, Canada ("Assignor"), JOHN KLEIN, an individual ("Assignee"),
and  PharmaKinetics  Laboratories,  Inc., a company  organized under the laws of
Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                   CAI ADVISORS & CO.


                                   By: /s/ LESLIE B. DANIELS
                                            Leslie B. Daniels
                                            Partner


                                   PHARMAKINETICS LABORATORIES, INC.


                                   By: /s/ JAMES K. LESLIE
                                            James K. Leslie
                                              President



                                   /s/ JOHN KLEIN
                                   JOHN KLEIN

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the  laws  of  Quebec,  Canada  ("Assignor"),   JOSEPH  RICARDO,  an  individual
("Assignee"),  and PharmaKinetics Laboratories,  Inc., a company organized under
the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                    CAI ADVISORS & CO.


                                    By: /s/ LESLIE B. DANIELS
                                             Leslie B. Daniels
                                             Partner


                                    PHARMAKINETICS LABORATORIES, INC.


                                    By:  /s/ JAMES K. LESLIE
                                             James K. Leslie
                                             President



                                    /s/ JOSEPH RICARDO
                                    JOSEPH RICARDO
 
                                                         3




                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of  Quebec,  Canada  ("Assignor"),  LESLIE B.  DANIELS,  an  individual
resident in New Jersey ("Assignee"),  and PharmaKinetics  Laboratories,  Inc., a
company organized under the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                               CAI ADVISORS & CO.


                               By: /s/ LESLIE B. DANIELS
                                        Leslie B. Daniels
                                        Partner


                               PHARMAKINETICS LABORATORIES, INC.


                               By: /s/ JAMES K. LESLIE
                                        James K. Leslie
                                        President




                               /s/ LESLIE B. DANIELS
                               LESLIE B. DANIELS

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of  Quebec,  Canada  ("Assignor"),  MICHAEL  F.  PRICE,  an  individual
resident in New Jersey ("Assignee"),  and PharmaKinetics  Laboratories,  Inc., a
company organized under the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing  all Shares,  Warrants,  Contingent  Warrants or Conversion  Shares
acquired by Assignee shall bear a legend reading substantially as follows:


                                                         1

<PAGE>



The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict  with  any  term  or  provision  of  any of  Assignor's  organizational
documents, or any other instrument,  law, statute, rule or regulation;  and (iv)
no authorization, consent, or approval

                                                         2

<PAGE>


of, or filing  or  registration  with,  any  court or  governmental  department,
commission,  or agency,  whether domestic or foreign, is or will be necessary in
connection  with the  execution  and  delivery by  Assignor  of this  Assignment
Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                    CAI ADVISORS & CO.


                                    By: /s/ LESLIE B. DANIELS
                                             Leslie B. Daniels
                                             Partner


                                    PHARMAKINETICS LABORATORIES, INC.


                                    By:  /s/ JAMES K. LESLIE
                                             James K. Leslie
                                             President




                                    /s/ MICHAEL F. PRICE
                                    MICHAEL F. PRICE

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec, Canada ("Assignor"), MANFRED YU, an individual ("Assignee"),
and  PharmaKinetics  Laboratories,  Inc., a company  organized under the laws of
Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing  all Shares,  Warrants,  Contingent  Warrants or Conversion  Shares
acquired by Assignee shall bear a legend reading substantially as follows:


                                                         1

<PAGE>



The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is not an  accredited  investor as defined in Regulation D
under the  Securities  Act.  Assignee has requisite  knowledge and experience in
financial and business  matters to render him fully  capable of  evaluating  the
merits  and  risks  of  the  purchase  of  the  Shares  and  Warrants.  Assignee
acknowledges that he has been furnished by  PharmaKinetics  with all information
required to be furnished to a nonaccredited  investor under paragraph (b)(2)(ii)
of Rule 502 of Regulation D promulgated  under the Securities Act.  Assignee can
bear the economic  risks of his investment and can afford a complete loss of his
investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of  complying  with  applicable  federal and state  securities  laws in
connection with the sale of Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this Assignment Agreement do not constitute, and with the passage of

                                                         2

<PAGE>


time or giving of notice will not constitute, a material default or violation of
or  conflict  with any term or  provision  of any of  Assignor's  organizational
documents, or any other instrument,  law, statute, rule or regulation;  and (iv)
no authorization,  consent,  or approval of, or filing or registration with, any
court or governmental  department,  commission,  or agency,  whether domestic or
foreign,  is or will be necessary in connection  with the execution and delivery
by Assignor of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                      CAI ADVISORS & CO.


                                      By: /s/ LESLIE B. DANIELS
                                               Leslie B. Daniels
                                               Partner


                                      PHARMAKINETICS LABORATORIES, INC.


                                      By: /s/ JAMES K. LESLIE
                                               James K. Leslie
                                               President



                                      /s/ MANFRED YU
                                      MANFRED YU

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec,  Canada  ("Assignor"),  PETER M.  GOTTSEGEN,  an  individual
("Assignee"),  and PharmaKinetics Laboratories,  Inc., a company organized under
the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing  all Shares,  Warrants,  Contingent  Warrants or Conversion  Shares
acquired by Assignee shall bear a legend reading substantially as follows:


                                                         1

<PAGE>



The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict  with  any  term  or  provision  of  any of  Assignor's  organizational
documents, or any other instrument,  law, statute, rule or regulation;  and (iv)
no authorization, consent, or approval

                                                         2

<PAGE>


of, or filing  or  registration  with,  any  court or  governmental  department,
commission,  or agency,  whether domestic or foreign, is or will be necessary in
connection  with the  execution  and  delivery by  Assignor  of this  Assignment
Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                     CAI ADVISORS & CO.


                                     By: /s/ LESLIE B. DANIELS
                                              Leslie B. Daniels
                                              Partner


                                     PHARMAKINETICS LABORATORIES, INC.


                                     By:  /s/ JAMES K. LESLIE
                                              James K. Leslie
                                              President



                                     /s/ PETER M. GOTTSEGEN
                                     PETER M. GOTTSEGEN

                                                         3




                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the  laws  of  Quebec,   Canada  ("Assignor"),   PETER  RESTLER,  an  individual
("Assignee"),  and PharmaKinetics Laboratories,  Inc., a company organized under
the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                CAI ADVISORS & CO.


                                By: /s/ LESLIE B. DANIELS
                                         Leslie B. Daniels
                                         Partner


                                PHARMAKINETICS LABORATORIES, INC.


                                By:  /s/ JAMES K. LESLIE
                                         James K. Leslie
                                         President




                                 /s/ PETER RESTLER
                                 PETER RESTLER

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec,  Canada  ("Assignor"),  RICHARD J.  SCHMEELK,  an individual
("Assignee"),  and PharmaKinetics Laboratories,  Inc., a company organized under
the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                  CAI ADVISORS & CO.


                                  By: /s/ LESLIE B. DANIELS
                                           Leslie B. Daniels
                                           Partner


                                  PHARMAKINETICS LABORATORIES, INC.


                                  By:  /s/ JAMES K. LESLIE
                                           James K. Leslie
                                           President



                                  /s/ RICHARD J. SCHMEELK
                                  RICHARD J. SCHMEELK

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of Quebec,  Canada  ("Assignor"),  THOMAS F. KEARNS, JR., an individual
resident in Connecticut ("Assignee"),  and PharmaKinetics Laboratories,  Inc., a
company organized under the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                  CAI ADVISORS & CO.


                                  By: /s/ LESLIE B. DANIELS
                                           Leslie B. Daniels
                                           Partner


                                  PHARMAKINETICS LABORATORIES, INC.


                                  By: /s/ JAMES K. LESLIE
                                           James K. Leslie
                                           President




                                  /s/ THOMAS F. KEARNS, JR.
                                  THOMAS F. KEARNS, JR.

                                                         3





                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the  laws  of  Quebec,   Canada  ("Assignor"),   WALTER  O'HARA,  an  individual
("Assignee"),  and PharmaKinetics Laboratories,  Inc., a company organized under
the laws of Maryland ("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for his own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing all Shares, Warrants, Contingent Warrants or

                                                         1

<PAGE>



Conversion Shares acquired by Assignee shall bear a legend reading substantially
as follows:

The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or his  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee,  himself or through his  representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
him fully  capable of  evaluating  the merits and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of his investment and
can afford a complete loss of his investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) his
purchase of Shares,  Warrants and Contingent Warrants, and (iii) his performance
of his obligations  under this Assignment and the obligations under the Purchase
Agreement that he is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms; (ii) Assignor has not previously

                                                         2

<PAGE>


assigned the rights  being  assigned  hereunder  to any other  party;  (iii) the
execution,  delivery  and  performance  of  this  Assignment  Agreement  do  not
constitute,  and  with  the  passage  of time  or  giving  of  notice  will  not
constitute,  a material  default or  violation  of or conflict  with any term or
provision  of  any  of  Assignor's   organizational   documents,  or  any  other
instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                   CAI ADVISORS & CO.


                                   By: /s/ LESLIE B. DANIELS
                                            Leslie B. Daniels
                                            Partner


                                   PHARMAKINETICS LABORATORIES, INC.


                                   By:  /s/ JAMES K. LESLIE
                                            James K. Leslie
                                            President



                                   /s/ WALTER O'HARA
                                   WALTER O'HARA
 
                                                         3





                                                         (accredited investor)
                              ASSIGNMENT AGREEMENT

         THIS  ASSIGNMENT  AGREEMENT is made and entered into as of the 19th day
of December 1997 by and among CAI ADVISORS & CO., a partnership  organized under
the laws of  Quebec,  Canada  ("Assignor"),  GES  INVESTMENTS  S.A.,  a  company
organized   under  the  laws  of  Belgium   ("Assignee"),   and   PharmaKinetics
Laboratories,   Inc.,   a  company   organized   under  the  laws  of   Maryland
("PharmaKinetics").

                               W I T N E S S E T H

         WHEREAS,  Assignor,  PharmaKinetics,  and Astero Cephac S.A., a company
organized under the laws of France ("Astero Cephac"), are parties to a Preferred
Share and Warrant  Purchase  Agreement  dated  December  4, 1997 (the  "Purchase
Agreement")  and a Registration  Rights  Agreement  dated December 19, 1997 (the
"Rights Agreement");

         WHEREAS,  pursuant to the  Purchase  Agreement,  Assignor has agreed to
purchase Shares and Warrants (as such terms are defined pursuant to Section 1 of
this Assignment  Agreement) from  PharmaKinetics  in the quantities set forth in
Schedule 1.1A to the Purchase Agreement;

         WHEREAS,  pursuant to Section 1.1 of the Purchase  Agreement,  Assignor
may assign its right to purchase  all or a portion of the Shares and Warrants to
one  or  more  affiliated  or  unaffiliated  third  parties  that  meet  certain
requirements set forth in the Purchase Agreement;

         WHEREAS,  Assignor desires to transfer its right to purchase Shares and
Warrants to Assignee, and Assignee desires to assume such rights;

         THEREFORE,  in consideration of the premises, and the mutual covenants,
terms and conditions contained herein, the parties hereto agree as follows:

         1. Definitions. All capitalized terms used but not defined in this 
Assignment Agreement shall have the meanings given to them in the Purchase 
Agreement.

         2. Assignment. Assignor hereby assigns to Assignee, and Assignee hereby
accepts and assumes,  all of Assignor's  rights to purchase  Shares and Warrants
under  the  Purchase  Agreement,  and all of  Assignor's  obligations  under the
Purchase Agreement and the Rights Agreement.

         3. Assignee's Representations.  Assignee hereby represents and warrants
to the Assignor and PharmaKinetics as follows:

         (a) Assignee intends to acquire Shares, Warrants,  Contingent Warrants,
and  Conversion  Shares for its own account.  All Shares,  Warrants,  Contingent
Warrants,  and Conversion  Shares to be acquired by Assignee will be acquired by
it for  investment  and  not  with a view to  distribution  or  resale  thereof.
Assignee  understands and agrees that, until registered under the Securities Act
or transferred  pursuant to Rule 144 under the Securities Act, all  certificates
representing  all Shares,  Warrants,  Contingent  Warrants or Conversion  Shares
acquired by Assignee shall bear a legend reading substantially as follows:

                                                         1

<PAGE>




The securities  represented by this  certificate  have not been registered under
the Securities Act of 1933 or applicable state securities laws. These securities
may not be offered for sale, sold, delivered after sale, transferred, pledged or
hypothecated in the absence of an effective registration statement covering such
securities  under  the Act and any  applicable  state  securities  laws,  or the
availability of an exemption from registration thereunder.

         (b) Assignee or its  representatives  have had the  opportunity  to ask
questions of and receive  answers from management of  PharmaKinetics  concerning
PharmaKinetics'  business,  assets, financial condition,  results of operations,
and liabilities.

         (c) Assignee is an accredited investor as defined in Regulation D under
the Securities Act. Assignee, by itself or through its representatives,  has the
requisite  knowledge and experience in financial and business  matters to render
it fully  capable of  evaluating  the merits  and risks of the  purchase  of the
Shares and Warrants.  Assignee can bear the economic risks of its investment and
can afford a complete loss of its investment.

         (d)  Assignee  has  obtained  each  required  authorization,   consent,
approval,  license,  qualification,  exemption of or filing or registration with
any court or  governmental  department,  commission,  board,  bureau,  agency or
instrumentality,  domestic  or foreign,  necessary  in  connection  with (i) the
execution  and  delivery  by  Assignee of this  Assignment  Agreement,  (ii) its
purchase of Shares,  Warrants and Contingent Warrants, and (iii) the performance
of its obligations  under this Assignment and the obligations under the Purchase
Agreement that it is assuming pursuant to this Assignment Agreement.

         4.  Acknowledgement  of Assignee.  Assignee  hereby  acknowledges  that
PharmaKinetics is relying on the representations and warranties made by Assignee
in Section 3 of this Assignment  Agreement in connection with the representation
made by PharmaKinetics  in the Purchase  Agreement that it has complied with all
applicable  federal and state securities laws,  including the Securities Act, in
connection with the offer, issuance and sale of Shares, Warrants, and Contingent
Warrants.

         5.   Acknowledgement   of   PharmaKinetics.    PharmaKinetics    hereby
acknowledges  that it has  received  all such  information  as it  requires  for
purposes of confirming that Assignee is an accredited  investor and of complying
with applicable federal and state securities laws in connection with the sale of
Shares and Warrants to Assignee.

         6. Representations of Assignor. Assignor hereby represents and warrants
to Assignee and to PharmaKinetics  that: (i) this Assignment  Agreement has been
duly authorized by all required partnership action, and as of the Closing,  will
be duly executed and delivered, and will constitute the legal, valid and binding
obligation of Assignor,  enforceable  against  Assignor in  accordance  with its
terms;  (ii)  Assignor has not  previously  assigned  the rights being  assigned
hereunder to any other party;  (iii) the execution,  delivery and performance of
this  Assignment  Agreement do not  constitute,  and with the passage of time or
giving of notice will not  constitute,  a material  default or  violation  of or
conflict  with  any  term  or  provision  of  any of  Assignor's  organizational
documents, or any other

                                                         2

<PAGE>


instrument,  law,  statute,  rule or  regulation;  and  (iv)  no  authorization,
consent,  or  approval  of,  or  filing  or  registration  with,  any  court  or
governmental department,  commission, or agency, whether domestic or foreign, is
or will be necessary in  connection  with the execution and delivery by Assignor
of this Assignment Agreement.

         IN WITNESS  WHEREOF,  the parties hereto have executed this  Assignment
Agreement on the day and year first written above.

                                         CAI ADVISORS & CO.


                                         By: /s/ LESLIE B. DANIELS
                                                  Leslie B. Daniels
                                                  Partner


                                         PHARMAKINETICS LABORATORIES, INC.


                                         By: /s/ JAMES K. LESLIE
                                                  James K. Leslie
                                                  President



                                         GES INVESTMENTS S.A.


                                         By: /s/ JOHN J. THEBAULT
                                                  John J. Thebault
                                                  President

                                                         3




CUSIP NO. 717131 106                      Schedule 13D/A


                                                             Exhibit 99.1

                             JOINT FILING AGREEMENT

         In accordance  with Rule  13d-1(f)(1)  of Regulation 13d of the General
Rules and  Regulations  of the  Securities  and  Exchange  Commission  under the
Securities Act of 1934, as amended, the undersigned agree to the joint filing on
behalf of each of them of this statement and any subsequent amendments thereto.

Date:  January 7, 1998




/s/ LESLIE B. DANIELS
Leslie B. Daniels



/s/ RICHARD J. SCHMEELK
Richard J. Schmeelk



/s/ PETER M. GOTTSEGEN
Peter M. Gottsegen



/s/ PETER G. RESTLER
Peter G. Restler



/s/ DAVID VON KAUFFMANN
David von Kauffmann



/s/ MANFRED YU
Manfred Yu






ASTER S.A.


By:      /s/ JEAN JACQUES THEBAULT
         Jean Jacques Thebault
         President



GES INVESTMENTS, S.A.


By:      /s/ JEAN JACQUES THEBAULT
         Jean Jacques Thebault
         President


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