INTERFERON SCIENCES INC
DEF 14A, 1997-04-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (RULE 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
           Proxy Statement Pursuant to Section 14(a) of the Securities
                      Exchange Act of 1934 (Amendment No. )

Filed by the  Registrant  Filed by a Party other than the  Registrant  Check the
appropriate box:
         Preliminary Proxy Statement
      x  Definitive Proxy Statement
         Definitive Additional Materials
         Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

         Confidential, for the use of the Commission Only (as permitted by
         Rule 14a-6(e)(2)


                            INTERFERON SCIENCES, INC.
                (Name of Registrant as Specified In Its Charter)

     Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

       x No fee required

         Fee computed on table below per Exchange Rules 14a-6(i)(4) and 0-11.
         (1)   Title of each class of securities to which transaction applies:

         (2)   Aggregate number of securities to which transaction applies:

         (3)   Per unit price or other underlying value of transaction  computed
               pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
               the filing fee is calculated and state how it was determined):

         (4)   Proposed maximum aggregate value of transaction:

         (5)   Total fee paid:


         Fee paid previously with preliminary materials.

         Check box if any part of the fee is offset as provided by Exchange  Act
         Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee
         was paid  previously.  Identify  the  previous  filing by  registration
         statement number, or the Form or Schedule and the date of its filing.

         (1)   Amount Previously Paid:

         (2)   Form, Schedule or Registration Statement No.:

         (3)   Filing Party:

(4)      Date Filed:



<PAGE>



                                                             






                            INTERFERON SCIENCES, INC.
                                783 JERSEY AVENUE
                         NEW BRUNSWICK, NEW JERSEY 08901

                    NOTICE  OF ANNUAL  MEETING OF  STOCKHOLDERS  To Be Held June
                            19, 1997


TO THE STOCKHOLDERS:

         The Annual Meeting of  Stockholders of Interferon  Sciences,  Inc. (the
"Company")  will be held at the  Brunswick  Hilton and  Towers,  3 Tower  Center
Boulevard,  East  Brunswick,  New  Jersey on the 19th day of June,  1997 at 1:30
p.m., local time, for the following purposes:

          1.   To elect nine  Directors  to serve until the next Annual  Meeting
               and until their respective successors are elected and qualify.

          2.   To transact  such other  business as may properly come before the
               meeting or any adjournment thereof.

                  Only  stockholders  of record as of the close of  business  on
         April 25,  1997 are  entitled  to receive  notice of and to vote at the
         meeting.  A list of such stockholders  shall be open to the examination
         of any stockholder  during ordinary business hours, for a period of ten
         days prior to the meeting,  at the principal  executive  offices of the
         Company, 783 Jersey Avenue, New Brunswick, New Jersey.

                       By Order of the Board of Directors
                               DONALD W. ANDERSON
                                                      Secretary



New Brunswick, New Jersey
April 30, 1997

         If you do not expect to be present at the meeting, please fill in, date
and sign the  enclosed  Proxy and  return it  promptly  in the  enclosed  return
envelope.










<PAGE>


                            INTERFERON SCIENCES, INC.
                                783 JERSEY AVENUE
                         NEW BRUNSWICK, NEW JERSEY 08901

                                                       New Brunswick, New Jersey
                                                                  April 30, 1997

                                 PROXY STATEMENT

         The  accompanying  Proxy is  solicited by and on behalf of the Board of
Directors of Interferon Sciences,  Inc., a Delaware corporation (the "Company"),
for use only at the Annual Meeting of  Stockholders  to be held at the Brunswick
Hilton and Towers, 3 Tower Center Boulevard,  East Brunswick,  New Jersey on the
19th day of June,  1997,  at 1:30  p.m.,  local  time,  and at any  adjournments
thereof. The approximate date on which this Proxy Statement and the accompanying
Proxy were first given or sent to security holders was May 1, 1997.

         Each Proxy executed and returned by a stockholder may be revoked at any
time thereafter,  by written notice to that effect to the Company,  attention of
the  Secretary,  prior  to  the  Annual  Meeting,  or to  the  Chairman,  or the
Inspectors of Election, at the Annual Meeting, or by the execution and return of
a  later-dated  Proxy,  except  as to  any  matter  voted  upon  prior  to  such
revocation.

         The Proxies in the  accompanying  form will be voted in accordance with
the specifications made and where no specifications are given, such Proxies will
be voted FOR the  nominees  for  election  as  directors  named  herein.  In the
discretion of the proxy  holders,  the Proxies will also be voted FOR or AGAINST
such other  matters as may properly come before the meeting.  The  management of
the Company is not aware that any other  matters are to be presented  for action
at the meeting.  The election of directors  will be determined by a plurality of
the votes of the shares of common  stock,  par value $.01 per share (the "Common
Stock"),  present in person or  represented  by proxy at the Annual  Meeting and
entitled  to vote on the  election  of  directors.  Accordingly,  in the case of
shares that are present or represented at the Meeting for quorum  purposes,  not
voting  such  shares  for  a  particular  nominee  for  director,  including  by
withholding  authority on the Proxy, will not operate to prevent the election of
such nominee if he or she otherwise receives a plurality of the votes.


                                VOTING SECURITIES

         The Board of  Directors  has fixed the close of  business  on April 25,
1997 as the  record  date for the  determination  of  stockholders  entitled  to
receive notice of and to vote at the Annual Meeting.  The issued and outstanding
stock of the Company on April 25, 1997 consisted of 12,285,105  shares of Common
Stock, each entitled to one vote. A quorum of the stockholders is constituted by
the  presence,  in person or by proxy,  of  holders  of record of Common  Stock,
representing  a majority of the number of votes  entitled  to be cast.  National
Patent  Development  Corporation  ("NPDC"),  which  beneficially owned 1,854,286
shares  of the  outstanding  Common  Stock  as of March  3,  1997  (representing
approximately  15.1%  of the  votes  entitled  to be cast at the  meeting),  has
advised  the  Company  that it  currently  intends  to vote all of the shares of
Common  Stock it  beneficially  owns for the  election  of the  directors  named
herein.

         All per share  amounts have been  adjusted for a  one-for-four  reverse
stock split that became  effective  as of 5:00 p.m.  New York City time on March
21, 1997.


<PAGE>


                             PRINCIPAL STOCKHOLDERS

         The  following  table sets  forth the number of shares of Common  Stock
beneficially  owned as of  March 3,  1997,  by each  person  who is known by the
Company to own  beneficially  more than 5% of the Company's  outstanding  Common
Stock.

Name and Address                             Number of shares      Percentage
of Beneficial Owner                         Beneficially Owned     of Class(1)

National Patent Development Corporation          1,854,286(2)         15.1%
Martin M. Pollak                                 1,994,911(2)(3)      16.1%
Jerome I. Feldman                                1,998,398(2)(4)      16.1%
Chancellor LGT Asset Management, Inc.            1,393,550(5)         11.3%
Forstmann-Leff Associates Inc.                     628,525(6)(7)       5.1%

(1)      The percentage of class  calculation  assumes for each beneficial owner
         that all of the options or warrants  are  exercised in full only by the
         named beneficial owner and that no other options or warrants are deemed
         to be exercised by any other stockholders.

(2)      Includes  (i)  1,310,537  shares of Common  Stock  owned by NPDC,  (ii)
         339,843 shares of Common Stock owned by Five Star Group, Inc. ("FSGI"),
         and (iii) 203,906 shares of Common Stock owned by MXL Industries,  Inc.
         ("MXL"). FSGI and MXL each is a wholly-owned  subsidiary of NPDC. Based
         upon the common stock and Class B Stock of NPDC outstanding at March 3,
         1997, Martin M. Pollak and Jerome I. Feldman, officers and directors of
         NPDC  and  directors  of  the  Company,  controlled  in  the  aggregate
         approximately  6.7% of the  voting  power of all voting  securities  of
         NPDC.  This percentage for Mr. Pollak and Mr. Feldman would increase to
         approximately 39.4% if they exercised all of the presently  outstanding
         and  currently  exercisable  stock  options to  purchase  shares of the
         common  stock  and  Class B Stock of NPDC  held by  them.  Accordingly,
         Messrs. Pollak and Feldman, through their ownership of common stock and
         Class B Stock of NPDC, may be deemed to beneficially  own the shares of
         Common Stock beneficially owned by NPDC, FSGI and MXL. However, Messrs.
         Pollak and Feldman  disclaim  beneficial  ownership  of such  1,854,286
         shares.  339,843 of the shares of Common  Stock owned by FSGI have been
         pledged to a bank by NPDC as collateral to secure  indebtedness owed to
         such bank. The address of NPDC and Messrs. Pollak and Feldman is 9 West
         57th Street, Suite 4170, New York, New York, 10019.

(3)      Includes (i)  1,854,286  shares of Common Stock  beneficially  owned by
         NPDC,  (ii)12,875 shares  beneficially  owned by Mr. Pollak,  (iii) 250
         shares of Common  Stock held by Mr.  Pollak's  wife,  and (iv)  127,500
         shares of Common Stock issuable upon exercise of currently  exercisable
         stock  options held by Mr.  Pollak.  Mr.  Pollak  disclaims  beneficial
         ownership of the shares of Common Stock owned by NPDC and his wife.

(4)      Includes (i)  1,854,286  shares of Common Stock  beneficially  owned by
         NPDC, (ii) 15,875 shares  beneficially owned by Mr. Feldman,  (iii) 737
         shares of Common Stock held by certain members of Mr. Feldman's family,
         and (iv)  127,500  shares of Common  Stock  issuable  upon  exercise of
         currently  exercisable  stock options held by Mr. Feldman.  Mr. Feldman
         disclaims  beneficial  ownership of the shares of Common Stock owned by
         NPDC and his family.

(5)      Shares owned by funds managed by Chancellor  LGT Asset  Management,
         Inc.,  which has voting  and  dispositive  power  with  respect to such
         shares of Common Stock. The address of Chancellor LGT Asset Management,
         Inc. is 50 California Street, San Francisco, California 94111.

(6)      Forstmann-Leff  Associates Inc., a registered  investment  adviser,
         has sole voting and  disposition  power with  respect to such shares of
         Common Stock. The address of  Forstman-Leff  Associates Inc. is 55 East
         52nd Street, New York, New York 10055.

(7)      Based on a Schedule 13G filed with the Securities and Exchange
         Commission.


          SECURITY OWNERSHIP OF DIRECTORS AND NAMED EXECUTIVE OFFICERS

         The  following  table  sets  forth,  as of  March 3,  1997,  beneficial
ownership of shares of Common Stock of the Company by each director, each of the
named executive officers and all directors and executive officers as a group.

                                                                 Of Total Number
                                                                    of Shares
                                                                  Beneficially
                                   Total Number    Percent of         Owned
                                     of Shares     Common         Shares Which
                                   Beneficially       Stock      May Be Acquired
Name                                   Owned        Owned(1)     Within 60 Days
- ----                                   -----        --------     --------------

Martin M. Pollak(2)(5)(7)            1,994,911         16.1%         127,500
Jerome I. Feldman(3)(5)(7)           1,998,398         16.1%         127,500
Samuel H. Ronel, Ph.D.(4)               90,250         *              83,875
Lawrence M. Gordon                      67,875         *              61,625
Stanley G. Schutzbank, Ph.D.            96,500         *              88,875
Drew Stoudt                             29,500         *              27,250
Mei-June Liao                            8,125         *               6,250
Scott N. Greenberg                      54,875         *              47,250
Leon Botstein, Ph.D.                     5,000         *               5,000
Roald Hoffmann, Ph.D.(6)                 1,250         *               1,250
Sheldon L. Glashow(6)                    1,250         *               1,250
Directors and Executive Officers
         as a Group (15 persons)     2,515,325         19.5%         599,000

*The number of shares owned is less than one percent of the  outstanding  shares
 of Common Stock.

(1)      The percentage of class  calculation  assumes for each beneficial owner
         that all of the options or warrants  are  exercised in full only by the
         named beneficial owner and that no other options or warrants are deemed
         to be exercised by any other stockholders.
(2)      See footnotes (2) and (3) to Principal Stockholders table.
(3)      See footnotes (2) and (4) to Principal Stockholders table.
(4)      Includes 3,875 shares  beneficially  held by Dr. Ronel and 2,500 shares
         of  Common  Stock  held  by  Dr.  Ronel's  wife.  Dr.  Ronel  disclaims
         beneficial ownership of the shares of Common Stock owned by his wife.
(5)      Member of the Executive Committee.
(6)      Member of the Audit Committee.
(7)      Member of the Compensation Committee.


                              ELECTION OF DIRECTORS

         Nine  directors will be elected at the meeting to hold office until the
next Annual Meeting of Stockholders  and until their  respective  successors are
elected and qualify.  The Proxies  solicited by this proxy  statement may not be
voted for a greater number of persons than the number of nominees  named.  It is
intended that these Proxies will be voted for the  following  nominees,  but the
holders of these Proxies reserve  discretion to cast votes for individuals other
than the nominees for director named below in the event of the unavailability of
any such nominee.  The Company has no reason to believe that any of the nominees
will  become  unavailable  for  election.  Set forth  below are the names of the
nominees,  the principal  occupation of each,  the year in which first elected a
director of the Company and certain  other  information  concerning  each of the
nominees.

         Martin M. Pollak has been a Director of the Company and a member of the
Executive  Committee  since  1981 and  Chairman  of the Board  from  1981  until
September l996. He is a founder of NPDC,  which is primarily a holding  company,
and has been Executive Vice President,  Treasurer,  and a director of NPDC since
1959.  Mr.  Pollak is Chief  Executive  Officer,  President  and a  director  of
American Drug Company  ("ADC"),  which provides  consulting  services to Western
companies doing business in Russia and Eastern  Europe.  He has been Chairman of
the Board of General  Physics  Corporation  ("GPC"),  and a director  from 1987;
Chairman of the Executive Committee of GTS Duratek,  Inc.  ("Duratek") from 1985
to 1995 and a director from 1982 until November 1996;  Chairman of the Board and
director of SGLG, since 1991; and a director of GSE Systems,  Inc. ("GSE") since
1994.  Mr.  Pollak is the former  Chairman of the Czech and Slovak United States
Economic Council, a trustee of the Board of Trustees of the Worcester Foundation
for Experimental  Biology and was a director of Brandon Systems Corporation from
1986 to 1996. Age 69.

         Jerome I.  Feldman  has been a Director  of the Company and a member of
the Executive  Committee since 1981,  Chairman of the Executive Committee of the
Company from 1981 until  September 1996 and Treasurer from 1984 until  September
1996.  Mr.  Feldman is founder  of,  and since  1959 has been  President,  Chief
Executive Officer, and a director of NPDC. He has been Chairman of the Executive
Committee  of GPC since 1988 and a director of GPC since  1987;  Chairman of the
Board of Duratek from 1985 to 1995 and a director from 1982 until November 1996;
Chairman of the  Executive  Committee  and a Director of SGLG since 1991;  and a
director of GSE since 1994 and Chairman of the Board of GSE since April 1997. He
is a trustee of the New England Colleges Fund and of Bard College. Age 68.

         Samuel H. Ronel,  Ph.D.  has been a Director of the Company  since 1981
and Chairman of the Board since February 1997. He was Vice Chairman from January
1996 until  February 1997 and was President and Chief  Executive  Officer,  from
1981 to  January  1996.  He was  responsible  for the  interferon  research  and
development  program since its inception in 1979.  Dr. Ronel joined NPDC in 1970
and served as the Vice  President of Research and  Development of NPDC from 1976
to  September  1996 and as the  President of Hydro Med  Sciences,  a division of
NPDC,  from  1976 to  September  1996.  Dr.  Ronel  served as  President  of the
Association  of   Biotechnology   Companies,   an   international   organization
representing United States and foreign  biotechnology  firms, from 1986-1988 and
has  served as a member of the Board of  Directors  until  1993.  Dr.  Ronel was
elected to the Board of Directors of the Biotechnology  Industry Organization in
1993. Age 60.

         Lawrence M. Gordon has been Chief  Executive  Officer and a director of
the Company  since  January  1996,  Vice  President  of the Company from 1991 to
January 1996, General Counsel of the Company since 1984, General Counsel of NPDC
since 1986, and Vice  President of NPDC from 1991 to September  1996. Mr. Gordon
has been a director of GPC since 1994. Age 43.

         Stanley G.  Schutzbank,  Ph.D.  has been President of the Company since
January 1996, Executive Vice President of the Company from 1981 to January 1996,
and a  director  of the  Company  since  1981 and has been  associated  with the
interferon  research and development  program since its inception in 1979. He is
involved with all facets of  administration  and planning of the Company and has
coordinated compliance with FDA regulations governing manufacturing and clinical
testing of  interferon,  leading to the approval of ALFERON N Injection in 1989.
Dr.  Schutzbank  joined  NPDC in 1972 and served as the  Corporate  Director  of
Regulatory and Clinical  Affairs of NPDC from 1976 until  September 1996, and as
Executive Vice President of Hydro Med Sciences from 1982 until  September  1996.
Dr. Schutzbank is a member of the Regulatory Affairs  Professionals  Society and
has  served as  Chairman  of the  Regulatory  Affairs  Certification  Board from
inception  until  1994.  Dr.  Schutzbank  received  the 1991  Richard  E.  Greco
Regulatory  Affairs  Professional  of the  Year  Award  for  his  leadership  in
developing the United States Regulatory Affairs Certification  Program. In 1995,
Dr.  Schutzbank was elected to serve as  President-elect  in 1996,  President in
1997, and Chairman of the Board in 1998 of the Regulatory Affairs  Professionals
Society. Age 51.

          Leon Botstein, Ph.D. has been a Director of the Company since 1981 and
has been  President of Bard College,  Annandale-on-Hudson,  New York since 1975.
Dr. Botstein was a Director of Intelogic Trace, Inc. from 1985 to 1995. Age 50.

         Scott N.  Greenberg  has been a director of the Company  since  January
1996, Vice  President,  Chief  Financial  Officer,  and a director of NPDC since
1989,  a director  of GPC since 1987,  a director of SGLG since 1991,  and Chief
Financial Officer of ADC since 1994. Age 40.

         Roald Hoffmann, Ph.D. has been a director of the Company since 1991 and
a director of NPDC since 1988.  Dr.  Hoffmann is a John A. Newman  Professor  of
Physical  Science  at  Cornell  University  since  1974 and is a  member  of the
National Academy of Sciences and the American  Academy of Arts and Sciences.  In
1981 he shared the Nobel Prize in Chemistry with Dr. Kenichi Fukui. Age 58.

          Sheldon L.  Glashow,  Ph.D.  has been a director of the Company  since
1991.  He has been a director of GPC since 1987, a director of GSE since 1995, a
director of CalCol,  Inc. since 1994, and was a director of Duratek from 1985 to
1995. Dr. Glashow is the Higgins  Professor of Physics and the Mellon  Professor
of the Sciences at Harvard  University.  He was a  Distinguished  Professor  and
Visiting  Professor of Physics at Boston  University.  In 1971,  he received the
Nobel Prize in Physics. Age 64.

Section 16 (a)  Beneficial Ownership Reporting Compliance

         The  Company  believes  that during the most recent  fiscal  year,  all
filing requirements applicable to its officers,  directors, and greater than 10%
beneficial  owners were complied with, except that James Knill and Magnus Precht
filed untimely reports on Form 3.

Board of Directors

         The Board of Directors has the  responsibility  for establishing  broad
corporate policies and for the overall  performance of the Company,  although it
is not involved in day-to-day  operating details.  Members of the Board are kept
informed of the Company's business by various reports and documents sent to them
as well as by  operating  and  financial  reports  made at Board  and  Committee
meetings.  The Board held two meetings in 1996. All of the directors attended at
least 75% of the  meetings  of the Board and  Committees  on which they  served,
except for Dr. Leon Botstein.



<PAGE>


Directors' Fees and Other Compensation

         Directors who are not employees of the Company received a fee of $1,000
for each  meeting of the Board of  Directors  attended,  but did not receive any
additional  compensation  for service on  committees  of the Board of Directors.
Officers of the Company do not receive  additional  compensation  for serving as
directors.

Executive Committee

         The Executive  Committee,  consisting of Martin M. Pollak and Jerome I.
Feldman,  meets on call and has  authority  to act on most  matters  during  the
intervals  between Board meetings.  The committee  formally acted seven times in
1996 through unanimous written consent.

Audit Committee

         The Audit  Committee  reviews the internal  controls of the Company and
the objectivity of its financial  reporting.  It meets with appropriate  Company
financial personnel and the Company's  independent  certified public accountants
in connection  with these reviews.  This  committee  recommends to the Board the
appointment of the independent certified public accountants to serve as auditors
for the following  year in examining  the books and records of the Company.  The
Audit Committee  currently consists of Roald Hoffmann and Sheldon L. Glashow and
met once in l997 to review the  Company's  financial  condition  and  results of
operations for the year ended December 31, l996.

Compensation Committee

         The Compensation  Committee,  consisting of Martin M. Pollak and Jerome
I.  Feldman,  meets on call and has the  authority  to act with  respect  to the
compensation of officers and employees of the Company. The Committee met once in
1996.



<PAGE>



                             EXECUTIVE COMPENSATION

         The following  table presents the  compensation  paid by the Company to
its Chief  Executive  Officer and the  Company's  four most  highly  compensated
executive officers for 1996.

<TABLE>

                           SUMMARY COMPENSATION TABLE

                               Annual Compensation
<CAPTION>
                                                                       Long Term
                                                                      Compensation
                                                                         Awards
                                                                         Stock              All Other
                                           Salary        Bonus          Options           Compensation
Name and Principal Position    Year          ($)          ($)             (#)                  ($)
- ---------------------------    ----          ---          ---             ---                  ---

<S>                <C>            <C>   <C>             <C>              <C>               <C>
Lawrence M. Gordon (1)            1996  135,000(1)      150,000          25,000            168,000(2)
Chief Executive Officer           1995    75,000(1)       -0-            27,500                -0-
                                  1994    75,000(1)     50,000            -0-                  -0-

Samuel H. Ronel, Ph.D.            1996  145,905(3)       52,500          41,375              8,363(4)
Chairman of the Board             1995  146,563(3)        -0-            18,750              6,110(4)
                                  1994  133,710(3)       30,000          57,625              6,306(4)

Stanley G. Schutzbank,            1996  197,341(5)       97,500          41,375              5,298(4)
Ph.D.                             1995  188,818(5)        -0-            31,250              4,998(4)
President                         1994  143,250(5)       50,000          57,625              4,601(4)

Drew Stoudt                       1996  119,452(6)      21,250           11,250              3,431(4)
Vice President, Regulatory        1995  114,018(6)        -0-            6,250               2,974(4)
Affairs and Quality               1994    88,354(6)     20,359           24,500              2,886(4)

Mei-June Liao, Ph.D.              1996  115,568          21,250           125                3,324(4)
Vice President, Research          1995  108,546           -0-            1,250               2,944(4)
and Development                   1994    92,061          -0-            3,875               2,491(4)
</TABLE>


(1)      Consists  of  $135,000  paid to Mr.  Gordon by NPDC for 1996,  1995 and
         1994,  respectively.  The  Company  reimbursed  NPDC for such amount in
         consideration  of NPDC's  permitting  Mr. Gordon to devote 60%, 33% and
         33%,  respectively,  of his working time to the Company for 1996,  1995
         and 1994, respectively.  Does not include additional salary paid to Mr.
         Gordon by NPDC for services  rendered solely to NPDC for 1996, 1995 and
         1994, respectively.

(2)      The  Company  forgave a $150,000  loan to Mr.  Gordon and also  forgave
         $18,000 of accrued  interest on such loan.  Such loan had been due July
         9, 1997 and bore interest at a rate of 6% per annum.

(3)      Dr. Ronel has been Chairman of the Board of the Company since  February
         1997,  was Vice  Chairman from January 1996 to February  1997,  and was
         President and Chief  Executive  Officer  until  January 1996.  Excludes
         $59,595,  $59,864 and $54,290  for 1996,  1995 and 1994,  respectively,
         paid by the Company to Dr.  Ronel for which the Company was  reimbursed
         by NPDC in  consideration  of the  Company's  permitting  Dr.  Ronel to
         devote a portion of his working hours to NPDC.

(4)      Matching  contribution  by the Company to the 401(k)  Savings Plan
         and payments by the Company for Group Term Life.

(5)      Dr. Schutzbank has been President of the Company since January 1996 and
         was  Executive  Vice  President  of the  Company  until  January  1996.
         Excludes  $21,927,   $20,980  and  $47,750  for  1996,1995,  and  1994,
         respectively,  paid by the  Company  to Dr.  Schutzbank  for  which the
         Company  was  reimbursed  by NPDC  in  consideration  of the  Company's
         permitting  Dr.  Schutzbank to devote a portion of his working hours to
         NPDC.

(6)      Excludes   $6,286,   $6,001  and  $22,088  for  1996,  1995  and  1994,
         respectively,  paid by the Company to Mr.  Stoudt for which the Company
         was reimbursed by NPDC in consideration of the Company's permitting Mr.
         Stoudt to devote a portion of his working hours to NPDC.



<PAGE>


                              Option Grants in 1996

         The following table sets forth certain information  relating to options
granted in 1996 to purchase shares of Common Stock of the Company.

<TABLE>

                                                                                                         Potential
                                                                                                        Realizable
<CAPTION>
                                                                                                         Value at
                                                  % of Total                                              Assumed
                                                    Options                                           Annual Rates of
                                                  Granted to     Exercise                               Stock Price
                                     Options       Employees      or Base                            Appreciation for
                                     Granted          in           Price     Expiration               Option Term(2)
                                     (#)(1)          1996         ($/Sh)        Date               5%              10%
                                     ------          ----         ------        ----               --              ---

<S>                                     <C>             <C>        <C>            <C>   <C>         <C>            <C>
Lawrence M. Gordon                      12,500          3.4%       $7.248         01/19/1999        $14,281        $29,989
                                        12,500          3.4%        $4.36         10/30/1999        $ 8,591        $18,040

Samuel H. Ronel, Ph.D.                   6,375          1.7%       $7.248         01/19/1999        $ 7,283        $15,294
                                         3,750          1.0%        $8.00         03/09/2001        $ 8,288        $18,315
                                         6,250          1.7%        $9.00         06/19/1999        $ 8,866        $18,619
                                        25,000          6.9%        $4.36         10/30/1999        $17,181        $36,079

Stanley G.
  Schutzbank, Ph.D.                      6,375          1.7%       $7.248         01/19/1999        $ 7,283        $15,294
                                         3,750          1.0%        $8.00         03/08/2001        $ 8,288        $18,315
                                         6,250          1.7%        $9.00         06/19/1999        $ 8,866        $18,619
                                        25,000          6.9%        $4.36         10/30/1999        $17,181        $36,079

Drew Stoudt                              2,500           .7%       $7.248         01/19/1999        $ 2,856        $ 5,998
                                         8,750          6.1%        $4.36         10/30/1999        $ 6,013        $12,628

Mei-June Liao, Ph.D.                       125           .1%       $7.248         01/19/1999        $   143        $   300

</TABLE>

         The 5% and 10% assumed  rates of stock  appreciation  used to calculate
         potential  gains  to  optionees  are  mandated  by  the  rules  of  the
         Commission.

(1)      Options were granted at 100% of fair market value on the date of the
         grant.

(2)      Represents  gain that would be realized  assuming the options were held
         for the entire three and five year terms and the stock price  increased
         at compounded  rates of 5% and 10% from a base price of $7.248,  $8.00,
         $9.00 and  $4.36.  The  potential  realizable  values per option or per
         share under such 5% and 10% rates of stock  appreciation would be $1.14
         and $2.40 per share for the $7.248 share price; $2.21 and $4.88 for the
         $8.00 share price;  $1.42 and $2.98 for the $9.00 share price; and $.69
         and $1.44 for the $4.36 share price.  These amounts  represent  assumed
         rates of  appreciations  only.  Actual gain, if any, on stock exercises
         and  Common  Stock   holdings  will  be  dependent  on  overall  market
         conditions and on the future  performance of the Company and its Common
         Stock.  There can be no  assurance  that the amount  reflected  in this
         table will be achieved.


<PAGE>



         The  following  table sets forth  information  for the named  executive
officers regarding  unexercised options held at the end of 1996. No options were
exercised by the named executive officers in 1996.

                    AGGREGATE DECEMBER 31, 1996 OPTION VALUES

<TABLE>
                                                                                             Value of Unexercised
<CAPTION>
                                        Number of Unexercised         In-the-Money
                                        Options at                    Options at
                                        December 31, 1996(#)          December 31, 1996($)(1)
                                        Exercisable/Unexercisable     Exercisable/Unexercisable

<S>                                         <C>            <C>           <C>          <C>
Lawrence M. Gordon                          61,625         16,500        $28,688      $  563
Samuel H. Ronel, Ph.D.                      83,875         11,250        $57,563      $1,406

Stanley G. Schutzbank, Ph.D.                88,875         18,750        $57,563      $1,406

Drew Stoudt                                 27,250          3,750        $19,819         -0-

Mei-June Liao, Ph.D.                         6,250          3,750            -0-         -0-

</TABLE>

(1) Calculated  based on the  closing  price of the  Common  Stock  ($6.625)  as
    reported by NASDAQ on December 31, 1996.

Compensation Committee Report on Executive Compensation

         The  Compensation   Committee  is  responsible  for  administering  the
compensation  program for the executive  officers of the Company,  including the
named executive officers.  The Compensation  Committee is currently comprised of
Messrs. Feldman and Pollak.

         The  Compensation   Committee's  executive  compensation  policies  are
designed  to  enhance  the  financial   performance  of  the  Company  and  thus
stockholder  value, by significantly  aligning the financial interest of the key
executives with those of stockholders. An executive's salary is determined by an
assessment of the significance of the executive's contribution to the operations
of the Company.

         The executive compensation program is reviewed in total considering all
of the component parts: base salary, annual bonus, and long-term compensation in
the form of stock options.  The  compensation  components  consist  generally of
relatively  lower base salaries  together  with  relatively  higher  performance
compensation through bonuses and stock options.

         In evaluating the  reasonableness of compensation paid to the Company's
executive officers,  the Committee takes into account how compensation  compares
to compensation paid by competing companies as well as the Company's performance
and the individual contribution of each executive officer.

         The  Compensation  Committee has from time to time  recommended  to the
Stock  Option  Committee  the grant of stock  options  to the  Company's  senior
management,  including the named  executive  officers,  whose  performance had a
significant  effect  on the  success  of the  Company.  These  option  grants to
management  reinforce the  Compensation  Committee's  philosophy that management
compensation should be closely linked with stockholder value.

         The Company has certain broad-based employee benefit plans in which all
employees,  including the named executive officers, are permitted to participate
on the same terms and conditions relating to eligibility and subject to the same
limitations on amounts that may be contributed. In 1996, the Company also made a
matching contribution to the 401(k) Savings Plan for those participants.

Mr. Gordon's 1996 Compensation

         In l996,  Mr.  Gordon  earned a base  salary of $135,000  for  services
rendered  to  the  Company  as  Chief  Executive  Officer.   In  addition,   the
Compensation  Committee  awarded Mr. Gordon a cash bonus of $150,000 and granted
him  options to purchase  25,000  shares of common  stock.  The  Committee  also
forgave a loan of $150,000 plus accrued interest of $18,000.

         In  reviewing  Mr.   Gordon's   performance  in  1996  and  determining
appropriate compensation, the Committee took the following major accomplishments
of the Company into consideration:

          the  strengthening  of the  Company's  financial  position  by raising
          needed  capital in 1996 of  approximately  $25,000,000  (less fees and
          expenses).

          the  reacquisition of the United States and Canadian  marketing rights
          to ALFERON N Injection(R) from Purdue.

          the significant  progress in the Company's  clinical  programs through
          the launch of two Phase 3 clinical  studies in major  indications (HIV
          infection and chronic hepatitis C) using ALFERON N Injection.

          the   development   of   international   marketing  and   distribution
          opportunities  through obtaining regulatory approvals in Germany, Hong
          Kong and Singapore and entering into a marketing  agreement  with Cell
          Pharm GmbH in Germany for ALFERON N Injection(R).

         Mr.  Gordon led the  Company's  efforts with respect to the  successful
consummation  of the  financing  transaction  in May 1996 of a  public  offering
underwritten  by Sunrise  Securities  Corp.,  pursuant to which the Company sold
2,000,000  shares of common stock and realized gross proceeds of $16,000,000.  A
portion of these funds ($3,760,000) was utilized by the Company to reacquire the
United  States and  Canadian  marketing  rights from Purdue,  which  enabled the
Company to make  significant  progress in achieving its goal of controlling  the
distribution of ALFERON N Injection(R),  which the Company believes will provide
it with  greater  financial  flexibility.  In April  1996,  Mr.  Gordon  led the
Company's  efforts in negotiating a marketing  agreement with Cell Pharm GmbH, a
privately-owned  pharmaceutical company headquartered in Germany. The Cell Pharm
Agreement,  as well as the foreign  regulatory  approvals,  further enhances the
Company's   efforts   to   distribute   and   market   ALFERON  N   Injection(R)
internationally.  In addition,  in December l996,  Mr. Gordon,  along with other
members  of  senior  management,  performed  an  integral  role  in  raising  an
additional  $9,124,375  of proceeds  in a private  placement  transaction  which
increased the Company's institutional shareholder base.

MARTIN M. POLLAK                                            JEROME I. FELDMAN

Compensation Committee Interlocks and Insider Participation in Compensation
Decisions

          Jerome I.  Feldman  and  Martin M.  Pollak  served as  members  of the
Compensation  Committee of the  Company's  Board of Directors.  Mr.  Feldman had
served as Chairman of the  Executive  Committee  of the Company  from 1981 until
September 1996 and Treasurer of the Company from 1984 until  September 1996. Mr.
Pollak had served as Chairman of the Board from 1981 until  September  1996. See
"Certain Transactions - Other Transactions".  In addition, Mr. Gordon, the Chief
Executive  Officer  and a director  of the  Company,  is a  director  of General
Physics  Corporation.  Mr. Feldman is Chief Executive Officer of General Physics
Corporation.


                                PERFORMANCE GRAPH

         The following  graph  compares the  performance  of the Company for the
period 1991 through 1996 with the performance of the Nasdaq Market Index and the
Dow Jones Industry Group BTC--Biotechnology.  The graph illustrates and compares
the 5 year cumulative  total return of a $100 investment on December 31, 1991 in
Interferon  Common  Stock,  NASDAQ  Market  Index and Dow Jones  Industry  Group
BTC-Biotechnology.  The values are as of December 31 of specified  year assuming
that dividends are reinvested.


                  Comparison of 5-Year Cumulative Total Return


 MEASUREMENT PERIOD
                                                                       NASDAQ
(FISCAL YEAR COVERED) INTERFERON SCIENCES, INC. DOW JONES BIOTECH   MARKET INDEX

        1991                   100.00                100.00            100.00
        1992                    36.11                 84.23            100.98
        1993                    52.09                 79.08            121.13
        1994                    14.93                 70.69            127.17
        1995                    20.83                120.64            164.96
        1996                    18.40                124.71            204.98

                              CERTAIN TRANSACTIONS

Agreements with NPDC

         Transfer  Agreement.  As of  January  1,  1981,  NPDC  entered  into an
agreement (the "Transfer Agreement") with the Company pursuant to which NPDC (i)
licensed to the Company in perpetuity all of its right,  title,  and interest in
and to certain  intellectual  property and  technology  rights (the  "Intangible
Assets") relating to its programs in human leukocyte  interferon and recombinant
DNA and hybridoma  technology,  and (ii)  transferred  to the Company its rights
under certain consulting, supply, and research agreements (the "Agreements"). In
consideration  of the license  and  transfer  of the  Intangible  Assets and the
Agreements,  the Transfer Agreement provides that the Company will pay to NPDC a
royalty of $1,000,000.  Such amount is payable if and when the Company generates
net income before income taxes,  and is limited to 25% of such net income before
taxes per year until the amount is paid in full.

         Management  Agreement.  As of  January  1, 1981,  NPDC  entered  into a
management  agreement (the "Management  Agreement") with the Company pursuant to
which certain legal, financial and administrative services have been provided by
employees of NPDC. The fee for such services is $120,000 per annum. In addition,
during 1996 NPDC charged the Company $349,758 for personnel and services,  which
the  Company  used in its  operations,  provided by NPDC to the  Company,  which
charges  represented  NPDC's  approximate  cost.  The Company  also charged NPDC
$351,759  for certain  services  rendered by  employees  of the Company to NPDC,
which charges represented the Company's approximate cost.
         Lease  Agreement.   The  Company  owns  two  free  standing   buildings
aggregating  approximately  44,000  square feet  located in New  Brunswick,  New
Jersey.  The Company and NPDC have entered into an agreement  for the sharing of
the  office,   warehouse  and   laboratory   facility.   The  Company   occupies
approximately  25,000 square feet, shares  approximately  9,000 square feet with
NPDC,  and  leases  approximately  10,000  square  feet of space to NPDC at such
location.  During 1996, NPDC paid the Company as rent NPDC's proportionate share
of such  occupancy  costs  (based on both  square  feet  occupied  and number of
personnel), which amounted to $258,984.

         While the  above-described  agreements were negotiated with a principal
stockholder of the Company which was then its parent,  the Company  nevertheless
believes  that  such  agreements  are  equivalent  economically  to  arms-length
transactions with a third party.

Other Transactions

         In September  l996,  Messrs.  Feldman,  Pollak and Greenberg,  officers
and/or directors of the Company,  received bonuses for services  rendered to the
Company valued at $85,950, $85,950 and $51,570, respectively.

                              STOCKHOLDER PROPOSALS

         Stockholders may present  proposals for inclusion in the Company's 1998
proxy statement  provided they are received by the Company no later than January
13, 1998,  and are  otherwise  in  compliance  with  applicable  Securities  and
Exchange Commission regulations.

                         INDEPENDENT PUBLIC ACCOUNTANTS

         The Audit  Committee  has  recommended,  and the Board of Directors has
selected, the firm of KPMG Peat Marwick LLP to serve as independent auditors for
the Company for the year ending  December  31,  1997.  KPMG Peat Marwick LLP has
audited the Company's  books since 1981.  The Board  considers KPMG Peat Marwick
LLP to be well qualified for the function of serving as the Company's auditors.

         A representative  of KPMG Peat Marwick LLP is expected to be present at
the Annual  Meeting,  will have the  opportunity  to make a  statement  if he so
desires,  and is expected to be  available to respond to  appropriate  questions
from stockholders.

                                     GENERAL

         So far as is now known,  there is no business other than that described
above to be presented for action by the  stockholders at the meeting,  but it is
intended  that the proxies  will be voted upon any other  matters and  proposals
that may  legally  come  before  the  meeting  and any  adjournments  thereof in
accordance with the discretion of the persons named therein.

                              COST OF SOLICITATION

         The cost of solicitation of proxies will be borne by the Company. It is
expected  that the  solicitations  will be made  primarily by mail,  but regular
employees  or  representatives  of the  Company  may  also  solicit  proxies  by
telephone or telegraph and in person, and arrange for brokerage houses and other
custodians,  nominees and fiduciaries to send proxy material to their principals
at the expense of the Company.

                                                              DONALD W. ANDERSON
                                                              Secretary

<PAGE>


COMMON STOCK             INTERFERON SCIENCES, INC.            PROXY

                         Annual Meeting of Stockholders
                            To Be Held June 19, 1997

           This proxy is solicited on behalf of the Board of Directors

         Revoking any such prior appointment,  the undersigned, a stockholder of
Interferon  Sciences,  Inc.,  hereby  appoints  Jerome I.  Feldman and Martin M.
Pollak,  and each of them,  attorneys and agents of the  undersigned,  with full
power of substitution, to vote all shares of the Common Stock of the undersigned
in said Company at the Annual Meeting of Stockholders of said Company to be held
at the Brunswick  Hilton and Towers, 3 Tower Center  Boulevard,  East Brunswick,
New Jersey on June 19,  1997,  at 1:30 P.M.  local time and at any  adjournments
thereof,  as fully and  effectually  as the  undersigned  could do if personally
present and voting,  hereby  approving,  ratifying and  confirming all that said
attorneys  and  agents  or their  substitutes  may  lawfully  do in place of the
undersigned as indicated below.

         This proxy when  properly  executed  will be voted as  directed.  If no
direction is indicated, this proxy will be voted for proposal (1).

          1. Election of Directors:  Martin M. Pollak, Jerome I. Feldman, Samuel
H. Ronel,  Lawrence M. Gordon,  Stanley G. Schutzbank,  Leon Botstein,  Scott N.
Greenberg, Roald Hoffmann and Sheldon L. Glashow.

                                                                        For All
(INSTRUCTION: To withhold           For       Withhold                  Except
authority to vote for any
individual nominee, write
that nominee's name in the
space provided below)


          2. Upon any other  matters  which may properly come before the meeting
or any adjournments thereof.





<PAGE>


         Please sign exactly as name appears below.

                                                     Dated                , 1997

                                                     Signature

                            Signature if held jointly

                                                     Please mark, sign, date and
                                                     return   the   proxy   card
                                                     promptly using the enclosed
                                                     envelope.  When  shares are
                                                     held by joint  tenants both
                                                     should  sign.  When signing
                                                     as  attorney,  as executor,
                                                     administrator,  trustee  or
                                                     guardian,  please give full
                                                     title   as   such.   If   a
                                                     corporation, please sign in
                                                     full   corporate   name  by
                                                     President      or     other
                                                     authorized  officer.  If  a
                                                     partnership  please sign in
                                                     partnership     name     by
                                                     authorized person.



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