INTERFERON SCIENCES INC
10-K/A, 1999-04-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 10-K/A

     /X/  Annual  Report  Pursuant  to  Section  13 or 15(d)  of the  Securities
          Exchange Act of 1934

          For the Fiscal Year Ended  December 31, 1998

     / /  Transition  Report  Pursuant to Section 13 or 15(d)of  the  Securities
          Exchange Act of 1934

          For the transition Period from ________to________

                         Commission File Number 0-10379

                            INTERFERON SCIENCES, INC.
             (Exact name of registrant as specified in its charter)

Delaware                                                    22-2313648
(State or other jurisdiction of                             (I.R.S. Employer
incorporation or organization)                              Identification No.)

783 Jersey Avenue, New Brunswick, New Jersey                  08901
(Address of principal executive offices)                      (Zip Code)

Registrant's telephone number, including area code:           (732) 249-3250

Securities registered pursuant to Section 12(b) of the Act:   None

Securities registered pursuant to Section 12(g) of the Act:

                     Common Stock, Par Value $0.01 Per Share
                                (Title of Class)

      Indicate by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  Period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days.

                                 Yes X No ----

     Indicate by check mark if disclosure of delinquent  filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to the
best of registrant's  knowledge,  in definitive proxy or information  statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. / /

     As of March 31, 1999, the aggregate market value of the outstanding  shares
of  the  registrant's   Common  Stock,  par  value  $.01  per  share,   held  by
non-affiliates  (assuming  for  this  calculation  only  that all  officers  and
directors  are  affiliates)  was  approximately  $2,300,000  based  on the  last
reported  sale price of such  stock on the  over-the-counter  bulletin  board on
March 31, 1999.

     Indicate  the  number of  shares  outstanding  of each of the  registrant's
classes of common stock, as of the latest practicable date.

       Class                               Outstanding at March 31 , 1999
       -----                               ------------------------------

Common Stock, par value $.01 per share       4,667,284 shares

                       DOCUMENTS INCORPORATED BY REFERENCE
None.

<PAGE>


                                                                                
     The Company's 10K for the year ended December 31, 1998 is hereby amended by
including Part III as follows:
                                    PART III

Item 10. Directors and Executive Officers of the Registrant

         Set forth below are the  officers  and  directors  of the Company as of
April 30, 1999.

       Samuel H. Ronel,  Ph.D. has been a Director of the Company since 1981 and
Chairman of the Board since  February  1997.  He was Vice  Chairman from January
1996 until  February 1997 and was President and Chief  Executive  Officer,  from
1981 to  January  1996.  He was  responsible  for the  interferon  research  and
development program since its inception in 1979. Dr. Ronel joined GP STRATEGIES,
Inc.  (formerly  National Patent  Development  Corporation)  ("NPDC"),  which is
primarily  a  holding  company,  in 1970 and  served  as the Vice  President  of
Research  and  Development  of NPDC  from  1976  to  September  1996  and as the
President  of Hydro Med  Sciences,  a division of NPDC,  from 1976 to  September
1996. Dr. Ronel served as President of Association of  Biotechnology  Companies,
an   international   organization   representing   United   States  and  foreign
biotechnology  firms,  from 1986 to 1988 and has served as a member of the Board
of Directors  until 1993. Dr. Ronel was elected to the Board of Directors of the
Biotechnology Industry Organization in 1993. Age 62.

      Lawrence M. Gordon has been Chief Executive  Officer and a director of the
Company since January 1996,  Vice  President of the Company from 1991 to January
1996, and General Counsel of the Company since 1984. Age 45.

       Stanley G.  Schutzbank,  Ph.D.  has been  President of the Company  since
January 1996, Executive Vice President of the Company from 1981 to January 1996,
and a  director  of the  Company  since  1981 and has been  associated  with the
interferon  research and development  program since its inception in 1979. He is
involved with all facets of  administration  and planning of the Company and has
coordinated compliance with FDA regulations governing manufacturing and clinical
testing of  interferon,  leading to the approval of ALFERON N Injection in 1989.
Dr.  Schutzbank  joined  NPDC in 1972 and served as the  Corporate  Director  of
Regulatory and Clinical  Affairs of NPDC from 1976 until  September 1996, and as
Executive Vice President of Hydro Med Sciences from 1982 until  September  1996.
Dr. Schutzbank is a member of the Regulatory Affairs  Professionals  Society and
has  served as  Chairman  of the  Regulatory  Affairs  Certification  Board from
inception  until  1994.  Dr.  Schutzbank  received  the 1991  Richard  E.  Greco
Regulatory  Affairs  Professional  of the  Year  Award  for  his  leadership  in
developing the United States Regulatory Affairs Certification  Program. In 1995,
Dr.  Schutzbank was elected to serve as  President-elect  in 1996,  President in
1997, and Chairman of the Board in 1998 of the Regulatory Affairs  Professionals
Society. Age 53.

     Sheldon L. Glashow, Ph.D. has been a director of the Company since 1991. He
has been a director of GPC since 1987,  a director of GSE since 1995, a director
of CalCol, Inc. since 1994, and was a director of Duratek from 1985 to 1995. Dr.
Glashow is the  Higgins  Professor  of Physics and the Mellon  Professor  of the
Sciences at Harvard  University.  He was a Distinguished  Professor and visiting
Professor of Physics at Boston University.  In 1971, he received the Nobel Prize
in Physics. Age 66.


<PAGE>


Item 11.   Executive Compensation

         The following  table presents the  compensation  paid by the Company to
its Chief  Executive  Officer and the  Company's  four most  highly  compensated
executive officers for 1998.

<TABLE>
<CAPTION>

                           SUMMARY COMPENSATION TABLE
                                                                               Long-Term
                                              Annual Compensation         Compensation Awards
                                              -------------------      -----------------------------
                                                                         Stock         All Other
                                    Year       Salary       Bonus       Options       Compensation
Name and Principal Position         ($)          ($)         ($)          (#)             ($)
- ---------------------------         ----       ------      ------       --------      ------------
<S>                                <C>        <C>          <C>            <C>          <C>    

Lawrence M. Gordon (1)             1998       270,000      103,000(6)     60,000        10,000(4)
Chief Executive Officer            1997       135,000(1)     - 0 -        42,525         4,718(4)
                                   1996       135,000(1)   150,000        25,000       168,000(2)

Samuel H. Ronel, Ph.D.             1998       213,000       27,000(6)     40,000        10,000(4)
Chairman of the Board              1997       205,154        - 0 -        51,200         5,083(4)
                                   1996       145,905(3)    52,000        41,375         5,298(4)

Stanley G. Schutzbank, Ph.D.       1998       251,000       77,000(6)     60,000        10,000(4)
President                          1997       231,302        - 0 -        51,750         4,860(4)
                                   1996       197,341(5)    97,500        41,375         5,298(4)

James Knill, M.D.                  1998       170,000       16,800(6)     10,000        10,000(4)
Vice President,                    1997       130,646        - 0 -        15,400         3,582(4)
Medical Affairs                    1996       119,452(6)    21,250        11,250         3,431(4)

Mei-June Liao, Ph.D.               1998       133,000       16,500(6)     15,000         7,500(4)
Vice President, Research           1997       122,380        - 0 -         7,325         3,744(4)
and Development                    1996       115,568       21,250           125         3,324(4)

</TABLE>


- ------------
[FN]
(1)  In 1997 and 1996, Mr. Gordon spent 60% of his time working on the Company's
     business.

(2)  The Company  forgave a $150,000 loan to Mr. Gordon and also forgave $18,000
     of accrued  interest on such loan.  Such loan had been due July 9, 1997 and
     bore interest at a rate of 6% per annum.

(3)  Dr.  Ronel has been  Chairman  of the Board of the Company  since  February
     1997,  was Vice  Chairman  from  January  1996 to  February  1997,  and was
     President and Chief Executive Officer until January 1996.  Excludes $59,595
     for 1996,  respectively,  paid by the  Company  to Dr.  Ronel for which the
     Company was reimbursed by NPDC in consideration of the Company's permitting
     Dr. Ronel to devote a portion of his working hours to NPDC.

(4)  Matching  contribution  by the  Company  to the  401(k)  Savings  Plan  and
     payments by the Company for Group Term Life.

(5)  Dr. Schutzbank has been President of the Company since January 1996 and was
     Executive  Vice  President  of the Company  until  January  1996.  Excludes
     $21,927  for 1996  paid by the  Company  to Dr.  Schutzbank  for  which the
     Company was reimbursed by NPDC in consideration of the Company's permitting
     Dr. Schutzbank to devote a portion of his working hours to NPDC.

(6)  Bonuses of $100,000, $25,000, $75,000, $15,000, and $15,000 paid to Messrs.
     Gordon, Ronel, Schutzbank, Knill and Ms. Liao, were paid in January 1998.
</FN>


<PAGE>


         The  following  table sets forth  information  for the named  executive
officers  regarding the unexercised  options held at the end of 1998. No options
were exercised by the named executive officers in 1998.

<TABLE>
<CAPTION>

                   AGGREGATED DECEMBER 31, 1998 OPTION VALUES


                                Number of Unexercised         Value of Unexercised
                                     Options at               In-the-Money Options at
                                December 31, 1998(#)          December 31, 1998($)(1)
                                Exercisable/Unexercisable    Exercisable/Unexercisable
                                -------------------------    -------------------------
<S>                             <C>            <C>            <C>            <C>    

Lawrence M. Gordon              30,877         48,128         $43,227        $67,379
Samuel H. Ronel, Ph.D.          29,571         32,694         $41,399        $45,771
Stanley G. Schutzbank, Ph.D.    36,615         48,260         $51,261        $67,564
James Knill, M.D.                4,200          9,040         $ 6,104        $12,656
Mei-June Liao, Ph.D.             5,871         12,169         $ 8,219        $17,036

</TABLE>













- -------------------
[FN]

(1)  Calculated  based on the closing  price of the Common  Stock as reported by
     NASDAQ on December 31, 1998.

</FN>


<PAGE>


Item 12.  Security Ownership Of Directors And Named Executive Officers


Principal Stockholders

      The  following  table  sets  forth the  number  of shares of Common  Stock
beneficially  owned as of March 31,  1999,  by each  person  who is known by the
Company to own  beneficially  more than 5% of the Company's  outstanding  Common
Stock.

Name and Address                              Number of Shares
of Beneficial Owner                           Beneficially Owned
- -------------------                           ------------------

GP Strategies, Inc.                                 301,800
9 West 57th Street
Suite 4170
New York, NY  10019


<PAGE>


         The  following  table  sets  forth,  as of April 30,  1999,  beneficial
ownership of shares of Common Stock of the Company by each director, each of the
named executive officers and all directors and executive officers as a group.

<TABLE>
<CAPTION>

                                                                     Of Total Number
                                                                        of Shares
                                                                      Beneficially
                                    Total Number      Percent of         Owned
                                      of Shares         Common        Shares which
                                    Beneficially        Stock        May be Acquired
Name                                   Owned           Owned(1)       Within 60 Days
- ----                                 ----------       ----------     -----------------
<S>                                     <C>             <C>              <C>    

Samuel H. Ronel, Ph.D.                   31,471           *               29,571
Lawrence M. Gordon                       31,777           *               30,877
Stanley G. Schutzbank, Ph.D.             38,140           *               36,615
Sheldon L. Glashow                        5,250           *                5,250
Directors and Executive Officers
  as a Group (9 persons)                375,000         7.5%             335,200


</TABLE>

- -------------
[FN]

*    The  number of shares  owned is less than one  percent  of the  outstanding
     shares of Common Stock.

(1)   The percentage of class calculation assumes for each beneficial owner that
      all of the options or  warrants  are  exercised  in full only by the named
      beneficial  owner and that no other  options or warrants  are deemed to be
      exercised by any other stockholders.

</FN>


<PAGE>


Item 13.  Certain Relationships and Related Transactions.

Agreements with NPDC

     Transfer  Agreement.  As of January 1, 1981, NPDC entered into an agreement
(the "Transfer  Agreement") with the Company pursuant to which NPDC (i) licensed
to the Company in  perpetuity  all of its right  title,  and  interest in and to
certain  intellectual  property and technology rights (the "Intangible  Assets")
relating to its programs in human  leukocyte  interferon and recombinant DNA and
hybridoma  technology,  and (ii)  transferred  to the Company  its rights  under
certain  consulting,  supply,  and research  agreements (the  "Agreements").  In
consideration  of the license  and  transfer  of the  Intangible  Assets and the
Agreements,  the Transfer Agreement provides that the Company will pay to NPDC a
royalty of $1,000,000.  Such amount is payable if and when the Company generates
net income before income taxes,  and is limited to 25% of such net income before
taxes per year until the amount is paid in full.

         Management  Agreement.  As of  January  1, 1981,  NPDC  entered  into a
management  agreement (the "Management  Agreement") with the Company pursuant to
which certain legal, financial and administrative services have been provided by
employees of NPDC. The fee for such services is $120,000 per annum.

       Lease  Agreement.  While the  above-described  agreements were negotiated
with a  principal  stockholder  of the Company  which was then its  parent,  the
Company nevertheless  believes that such agreements are equivalent  economically
to arms-length transactions with a third party.

Other Transactions

         In an agreement dated March 25, 1999, GP Strategies  agreed to lend the
Company $500,000 at the rate of $250,000 a month (the "GP Strategies  Debt"). In
return,  the Company  agreed to grant GP Strategies  (i) a first mortgage on the
Company's  real estate,  (ii) a two-year  option to purchase the Company's  real
estate,  provided that the Company has  terminated  its  operations  and the Red
Cross Debt has been repaid,  and (iii) a two-year  right of first refusal in the
event the Company  desires to sell its real  estate.  In  addition,  the Company
agreed to allow a designee of GP  Strategies  to attend any meeting with the FDA
with respect to approval of ALFERON N Injection  for the  treatment  hepatitis B
and to issue GP Strategies  500,000 shares of Common Stock and five-year options
to  purchase  500,000  shares of Common  Stock at a price of $1 per  share.  The
Company  also  agreed  not to  increase  its  payroll  during the term of the GP
Strategies  Debt  without the prior  consent of GP  Strategies.  Pursuant to the
agreement,  the Company has issued a note to GP Strategies  representing  the GP
Strategies  Debt,  which note matures on September 30, 1999 and bears  interest,
payable at maturity,  at the rate of 6% per annum. In addition,  the Company has
negotiated a  subordination  agreement  with the Red Cross pursuant to which the
Red Cross has agreed that its lien on the Company's  real estate is  subordinate
to GP Strategies' lien.

Employment Agreement

         As of October 1, 1997,  Lawrence M. Gordon and the Company entered into
an  employment  agreement  pursuant to which Mr. Gordon is employed as the Chief
Executive  Officer of the Company until December 31, 2001. On December 31, 1999,
and on each  December  31 of each  year  thereafter,  the  employment  period is
automatically  extended for one additional  year unless,  not later than June 30
immediately  preceding any such December 31, either party  delivers to the other
written notice that the employment period is not further extended.

         Commencing  January  1,  1997,  Mr.  Gordon's  base  annual  salary  is
$250,000,  subject to annual  increases  of 6%. The Company  granted Mr.  Gordon
under the  Company's  option  plan  options to  purchase  150,000  shares of the
Company's  common  stock at an exercise  price of $8.50.  Such  options vest 20%
immediately  and 20% on each January 1 commencing  January 1, 1998 and terminate
on December  31,  2001.  The  Company's  Board of Directors  may  determine  Mr.
Gordon's  bonus  for each  year,  and  whether  to grant Mr.  Gordon  additional
options,  based  upon the  Company's  revenues,  profits  or  losses,  financing
activities,  progress in clinical trials, and such other factors deemed relevant
by the Board.

         The Company may terminate the employment  agreement for Cause, which is
defined as (i) the willful and continued  failure by Mr. Gordon to substantially
perform his duties or obligations or (ii) the willful  engaging by Mr. Gordon in
misconduct  which  is  materially   monetarily  injurious  to  the  Company.  If
employment agreement is terminated for Cause, the Company is required to pay Mr.
Gordon his full salary through the termination date.

         Mr.  Gordon can  terminate  the  employment  agreement for Good Reason,
which is defined as (i) a change in control of the  Company or (ii) a failure by
the Company to comply with any material  provision of the  employment  agreement
which has not been cured within ten days after notice.  A "change in control" of
the  Company is  defined  as (i) a change in  control of a nature  that would be
required to be  reported in response to Item 1(a) of Current  Report on Form 8-K
pursuant  to Section  13 or 15(d) of the  Securities  Exchange  Act of 1934 (the
"Exchange  Act"),  (ii) any "person" (as such term is used in Sections 13(d) and
14(d) of the Exchange Act) is or becomes the  "beneficial  owner" (as defined in
Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the
Company  representing  20% or more of the combined voting power of the Company's
then  outstanding  securities,  or (iii) at any time individuals who were either
nominated for election or elected by the Board of Directors of the Company cease
for any reason to constitute at least a majority of the Board.

         If the Company  wrongfully  terminates the employment  agreement or Mr.
Gordon terminates the employment agreement for Good Reason, then (i) the Company
is required to pay Mr. Gordon his full salary through the termination date; (ii)
the Company is required to pay as severance pay to Mr. Gordon an amount equal to
(a) Mr. Gordon's average annual cash  compensation  received from the Company or
GP  Strategies  Corporation  during the three full  calendar  years  immediately
preceding the termination date,  multiplied by (b) the greater of (I) the number
of years  (including  partial  years)  that  would  have been  remaining  in the
employment  period if the  employment  agreement had not so terminated  and (II)
three,  such  payment  to be made (c) if  termination  is  based on a change  of
control of the Company,  in a lump sum on or before the fifth day  following the
termination  date  or (d) if  termination  results  from  any  other  cause,  in
substantially  equal semimonthly  installments  payable over the number of years
(including  partial  years)  that would have been  remaining  in the  employment
period if the employment  agreement had not so terminated;  (iii) all options to
purchase the  Company's  common stock  granted to Mr. Gordon under the Company's
option plan or otherwise  immediately  become fully vested and terminate on such
date as they would have terminated if Mr. Gordon's employment by the Company had
not terminated and, if Mr. Gordon's  termination is based on a change of control
of the Company and Mr.  Gordon elects to surrender any or all of such options to
the Company,  the Company is required to pay Mr.  Gordon a lump sum cash payment
equal to the excess of (a) the fair market value on the termination  date of the
securities  issuable  upon  exercise  of the  options  surrendered  over (b) the
aggregate exercise price of the options surrendered;  and (iv) if termination of
the employment  agreement arises out of a breach by the Company,  the Company is
required  to pay all other  damages  to which Mr.  Gordon may be  entitled  as a
result of such breach. If the employment  agreement is terminated for any reason
other than Cause,  the Company is required to maintain in full force and effect,
for a number of years equal to the greater of (i) the number of years (including
partial years) that would have been  remaining in the  employment  period if the
employment  agreement had not so terminated and (ii) three, all employee benefit
plans and programs in which Mr. Gordon was entitled to  participate  immediately
prior to the termination date.


<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.


                                               INTERFERON SCIENCES, INC.



                                       By: /s/ Lawrence M. Gordon
                                               ------------------------
                                               Lawrence M. Gordon
                                               Chief Executive Officer





Dated:  April 30, 1999




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