INTERFERON SCIENCES INC
10-K/A, 2000-04-27
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                   FORM 10-K/A

/X/ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act
    of 1934

        For the Fiscal Year Ended December 31, 1999

/ / Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange
    Act of 1934

    For the transition Period from ________to________

                         Commission File Number 0-10379

                            INTERFERON SCIENCES, INC.
             (Exact name of registrant as specified in its charter)

Delaware                                                     22-2313648
(State or other jurisdiction of                              (I.R.S. Employer
incorporation or organization)                               Identification No.)

783 Jersey Avenue, New Brunswick, New Jersey                  08901
(Address of principal executive offices)                      (Zip Code)

Registrant's telephone number, including area code:           (732) 249-3250

Securities registered pursuant to Section 12(b) of the Act:   None

Securities registered pursuant to Section 12(g) of the Act:

                     Common Stock, Par Value $0.01 Per Share

                                (Title of Class)

      Indicate by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  Period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days.

                                 Yes X No ----

         Indicate by check mark if disclosure of delinquent  filers  pursuant to
Item 405 of Regulation S-K is not contained  herein,  and will not be contained,
to the best of  registrant's  knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. / /

         As of April 1, 2000,  the  aggregate  market  value of the  outstanding
shares of the  registrant's  Common  Stock,  par value $.01 per  share,  held by
non-affiliates  (assuming  for  this  calculation  only  that all  officers  and
directors  are  affiliates)  was  approximately  $14,500,000  based  on the last
reported sale price of such stock on the OTC Bulletin Board on April 1, 2000.

         Indicate the number of shares  outstanding of each of the  registrant's
classes of common stock, as of the latest practicable date.

       Class                               Outstanding at April 1, 2000
       -----                               ------------------------------

Common Stock, par value $.01 per share       5,387,473 shares

                       DOCUMENTS INCORPORATED BY REFERENCE
None.

<PAGE>




         The  Company's  10K for the year  ended  December  31,  1999 is  hereby
amended by including Part III as follows:

                                    PART III

Item 10. Directors and Executive Officers of the Registrant

         Set forth below are the  officers  and  directors  of the Company as of
April 1, 1999.

         Samuel H. Ronel,  Ph.D.  has been Chairman of the Board since  February
1997 and was Vice  Chairman of the Board from January 1996 to February  1997 and
President,  Chief Executive Officer,  and a director of the Company from 1981 to
January 1996. He was  responsible  for the interferon  research and  development
program since its inception in 1979. Dr. Ronel joined GP Strategies  Corporation
("GP  Strategies")  in 1970 and served as the Vice  President  of  Research  and
Development  of GP  Strategies  and as the  President of Hydro Med  Sciences,  a
division of GP  Strategies,  from 1976 to  September  1996.  Dr. Ronel served as
President  of the  Association  of  Biotechnology  Companies,  an  international
organization  representing United States and foreign  biotechnology  firms, from
1986-88 and has served as a member of its Board of  Directors  until  1993.  Dr.
Ronel  was  elected  to the Board of  Directors  of the  Biotechnology  Industry
Organization  from  1993  to 1995  and to the  Governing  Body  of the  Emerging
Companies  Section  from  1993 to 1997.  Since  1999 he has been a member of the
Technology Advisory Board of the New Jersey Economic Development Authority.  Age
63.

         Lawrence M. Gordon has been Chief  Executive  Officer and a director of
the Company since January 1996,  Vice President of the Company from June 1991 to
January 1996, General Counsel of the Company from 1984 to January 1996. Age 46.

         Stanley G.  Schutzbank,  Ph.D.  has been President of the Company since
January 1996, Executive Vice President of the Company from 1981 to January 1996,
and a  director  of the  Company  since  1981 and has been  associated  with the
interferon  research and development  program since its inception in 1979. He is
involved with all facets of  administration  and planning of the Company and has
coordinated compliance with FDA regulations governing manufacturing and clinical
testing of  interferon,  leading to the approval of ALFERON N Injection in 1989.
Dr. Schutzbank joined GP Strategies in 1972 and served as the Corporate Director
of Regulatory and Clinical  Affairs of GP Strategies from 1976 to September 1996
and as Executive  Vice  President  of Hydro Med Sciences  from 1982 to September
1996. Dr. Schutzbank is a member of the Regulatory Affairs Professionals Society
and has served as Chairman of the Regulatory  Affairs  Certification  Board from
its  inception  until 1994.  Dr.  Schutzbank  received the 1991 Richard E. Greco
Regulatory  Affairs  Professional  of the  Year  Award  for  his  leadership  in
developing  the United  States  Regulatory  Affairs  Certification  Program.  In
September 1995, Dr. Schutzbank was elected to serve as  President-elect in 1996,
President in 1997, and Chairman of the Board in 1998 of the  Regulatory  Affairs
Professionals Society. Age 56.

Sheldon L. Glashow,  Ph.D. has been a director of the Company since 1991. He has
been a director of GP  Strategies  since 1987, a director of GSE  Systems,  Inc.
since  1995,  and a director of CalCol,  Inc.  since  1994.  Dr.  Glashow is the
Higgins Professor of Physics and the Mellon Professor of the Sciences at Harvard
University.  He was a Distinguished  Professor and visiting Professor of Physics
at Boston University. In 1971, he received the Nobel Prize in Physics. Age 67.



<PAGE>


Item 11.   Executive Compensation

         The following  table presents the  compensation  paid by the Company to
its Chief  Executive  Officer and the  Company's  four most  highly  compensated
executive officers for 1999.
<TABLE>
<CAPTION>

                           SUMMARY COMPENSATION TABLE

                                                                                      Long-Term
                                                      Annual Compensation         Compensation Awards
                                                      -------------------      -----------------------------
<S>                                 <C>               <C>           <C>         <C>               <C>
                                                                                Stock             All Other
                                    Year              Salary       Bonus       Options           Compensation
Name and Principal Position                            ($)         ($)          (#)                 ($) (3)
- ---------------------------         ----              ------      ------       --------          ------------

Lawrence M. Gordon (1)              1999              135,800(1)     - 0 -       400,000             9,059
Chief Executive Officer             1998              270,000       103,000       60,000            10,000
                                    1997              135,000(2)     - 0 -        42,525             4,718

Samuel H. Ronel, Ph.D.              1999              103,000(1)     - 0 -       250,000             8,916
Chairman of the Board               1998              213,000        27,000       40,000            10,000
                                    1997              205,154        - 0 -        51,200             5,083

Stanley G. Schutzbank, Ph.D.        1999              123,400(1)     - 0 -       400,000             8,261
President                           1998              251,000        77,000       60,000            10,000
                                    1997              231,302        - 0 -        51,750             4,860

James Knill, M.D.                   1999              120,800(1)     - 0 -        50,375            12,692
Vice President                      1998              170,000        16,800       10,000            10,000
Medical Affairs                     1997              130,646        - 0 -        15,400             3,582

Mei-June Liao, Ph.D.                1999              113,200(1)     - 0 -        81,075             6,952
Vice President, Research            1998              133,000        16,500       15,000             7,500
and Development                     1997              122,380        - 0 -         7,325             3,744

- ------------

(1)      In 1999, due to the financial condition of the Company, Messrs. Gordon, Ronel, Schutzbank, Knill and Ms. Liao, reduced the
         amount of time they spent on Company business.

(2)      In 1997, Mr. Gordon spent 60% of his time working on the Company's business.

(3)      Matching contribution by the Company to the 401(k) Savings Plan and payments by the Company for Group Term Life.

</TABLE>


<PAGE>


         The  following  table sets forth  information  for the named  executive
officers  regarding the unexercised  options held at the end of 1999. No options
were exercised by the named executive officers in 1999.

<TABLE>
<CAPTION>

                   AGGREGATED DECEMBER 31, 1999 OPTION VALUES

                                Number of Unexercised         Value of Unexercised
                                     Options at               In-the-Money Options at

                                December 31, 1999(#)          December 31, 1999($)(1)
                                Exercisable/Unexercisable    Exercisable/Unexercisable
                                -------------------------    -------------------------
<S>                              <C>            <C>             <C>            <C>
Lawrence M. Gordon              165,653        343,352        $8,282         $17,167
Samuel H. Ronel, Ph.D.          103,469        208,796         5,173          10,439
Stanley G. Schutzbank, Ph.D.    153,535        331,340         7,676          16,567
James Knill, M.D.                19,634         44,141           981           2,207
Mei-June Liao, Ph.D.             30,363         68,752         1,518           3,437
- -------------------

(1)      Calculated based on the closing price of the Common Stock as reported on the
         OTC Bulletin Board on December 31, 1999.

</TABLE>


<PAGE>


Item 12.  Security Ownership Of Directors And Named Executive Officers


Principal Stockholders

      The  following  table  sets  forth the  number  of shares of Common  Stock
beneficially  owned as of  April 1,  2000,  by each  person  who is known by the
Company to own  beneficially  more than 5% of the Company's  outstanding  Common
Stock.

<TABLE>
<CAPTION>

Name and Address                              Number of Shares
of Beneficial Owner                           Beneficially Owned
- -------------------                           ------------------
<S>                                               <C>
GP Strategies Corporation                        969,000 (1)
9 West 57th Street
Suite 4170
New York, NY  10019



(1)  Includes  500,000  shares  which may be  acquired  upon the  exercise  of a
     warrant, exercisable until March 2004, at a price of $1.00 per share.

</TABLE>

<PAGE>


         The  following  table  sets  forth,  as of  April 1,  2000,  beneficial
ownership of shares of Common Stock of the Company by each director, each of the
named executive officers and all directors and executive officers as a group.

<TABLE>
<CAPTION>

                                                                       Of Total Number
                                                                          of Shares
                                                                       Beneficially
                                    Total Number      Percent of          Owned
                                      of Shares         Common         Shares which
                                    Beneficially        Stock        May be Acquired
Name                                   Owned           Owned(1)       Within 60 Days
- ----                                 ----------       ----------     -----------------
<S>                                     <C>             <C>                <C>
Samuel H. Ronel, Ph.D.                 313,765          5.5%              176,617
Lawrence M. Gordon                     509,905          8.6%              287,329
Stanley G. Schutzbank, Ph.D.           484,875          8.3%              269,205
Sheldon L. Glashow                      22,250           *                 19,350
Directors and Executive Officers     1,608,003          23%               906,539
  as a Group (8 persons)



 -------------

* The number of shares owned is less than one percent of the outstanding  shares
of Common Stock.

(1)   The percentage of class calculation assumes for each beneficial owner that
      all of the options or  warrants  are  exercised  in full only by the named
      beneficial  owner and that no other  options or warrants  are deemed to be
      exercised by any other stockholders.
</TABLE>


<PAGE>


Item 13.  Certain Relationships and Related Transactions.

Agreements with NPDC

         Transfer  Agreement.  As of  January  1,  1981,  NPDC  entered  into an
agreement (the "Transfer Agreement") with the Company pursuant to which NPDC (i)
licensed to the Company in  perpetuity  all of its right title,  and interest in
and to certain  intellectual  property and  technology  rights (the  "Intangible
Assets") relating to its programs in human leukocyte  interferon and recombinant
DNA and hybridoma  technology,  and (ii)  transferred  to the Company its rights
under certain consulting, supply, and research agreements (the "Agreements"). In
consideration  of the license  and  transfer  of the  Intangible  Assets and the
Agreements,  the Transfer Agreement provides that the Company will pay to NPDC a
royalty of $1,000,000.  Such amount is payable if and when the Company generates
net income before income taxes,  and is limited to 25% of such net income before
taxes per year until the amount is paid in full.

Other Transactions

         In an agreement dated March 25, 1999, GP Strategies  agreed to lend the
Company $500,000 at the rate of $250,000 a month (the "GP Strategies  Debt"). In
return,  the Company  agreed to grant GP Strategies  (i) a first mortgage on the
Company's  real estate,  (ii) a two-year  option to purchase the Company's  real
estate,  provided that the Company has  terminated  its  operations  and the Red
Cross Debt has been repaid,  and (iii) a two-year  right of first refusal in the
event the Company  desires to sell its real  estate.  In  addition,  the Company
agreed to issue GP  Strategies  500,000  shares of  Common  Stock and  five-year
options to purchase  500,000  shares of Common Stock at a price of $1 per share.
Pursuant  to the  agreement,  the  Company  has  issued a note to GP  Strategies
representing  the GP Strategies  Debt,  which note matures on September 30, 1999
and  bears  interest,  payable  at  maturity,  at the rate of 6% per  annum.  In
addition,  the Company has  negotiated a  subordination  agreement  with the Red
Cross  pursuant to which the Red Cross has agreed that its lien on the Company's
real estate is  subordinate  to GP  Strategies'  lien.  On March 27,  2000,  the
Company and GP Strategies entered into an agreement pursuant to which (i) the GP
Strategies  Debt was extended  until June 30, 2001,  (ii) the Company  agreed to
file a  registration  statement  prior  to July 31,  2000  covering  the  shares
issuable upon exercise of the GP Warrant and any of the GP Shares for which Rule
144 under the Securities Act of 1933 was not available, and (iii) the Management
Agreement  between  the  Company  and  GP  Strategies  was  terminated  and  all
intercompany  accounts between the Company and GP Strategies  (other than the GP
Strategies  Debt) in the amount of $130,000 were discharged and eliminated.  The
agreement  also provides  that (i)  commencing on May 1, 2001 and ending on June
30, 2001,  on any day ISI may require GP  Strategies  to exercise the GP Warrant
and sell the underlying  shares, if the market price of ISI Common Stock exceeds
$1.00 per share on each of the 10 trading  days prior to any such day,  and (ii)
any  proceeds  from the sale of the  shares  issuable  upon  exercise  of the GP
Warrant in excess of the aggregate amount paid by GP Strategies to purchase such
shares,  would be deemed to reduce the then outstanding  amount of principal and
interest of the GP Strategies Debt until such amount is reduced to zero.

Employment Agreement

         As of October 1, 1997,  Lawrence M. Gordon and the Company entered into
an  employment  agreement  pursuant to which Mr. Gordon is employed as the Chief
Executive  Officer of the Company until December 31, 2001. On December 31, 1999,
and on each  December  31 of each  year  thereafter,  the  employment  period is
automatically  extended for one additional  year unless,  not later than June 30
immediately  preceding any such December 31, either party  delivers to the other
written notice that the employment period is not further extended.

         Commencing  January  1,  1997,  Mr.  Gordon's  base  annual  salary  is
$250,000,  subject to annual  increases  of 6%. The Company  granted Mr.  Gordon
under the  Company's  option  plan  options to  purchase  150,000  shares of the
Company's  common  stock at an exercise  price of $8.50.  Such  options vest 20%
immediately  and 20% on each January 1 commencing  January 1, 1998 and terminate
on December  31,  2001.  The  Company's  Board of Directors  may  determine  Mr.
Gordon's  bonus  for each  year,  and  whether  to grant Mr.  Gordon  additional
options,  based  upon the  Company's  revenues,  profits  or  losses,  financing
activities,  progress in clinical trials, and such other factors deemed relevant
by the Board.

         The Company may terminate the employment  agreement for Cause, which is
defined as (i) the willful and continued  failure by Mr. Gordon to substantially
perform his duties or obligations or (ii) the willful  engaging by Mr. Gordon in
misconduct  which  is  materially   monetarily  injurious  to  the  Company.  If
employment agreement is terminated for Cause, the Company is required to pay Mr.
Gordon his full salary through the termination date.

         Mr.  Gordon can  terminate  the  employment  agreement for Good Reason,
which is defined as (i) a change in control of the  Company or (ii) a failure by
the Company to comply with any material  provision of the  employment  agreement
which has not been cured within ten days after notice.  A "change in control" of
the  Company is  defined  as (i) a change in  control of a nature  that would be
required to be  reported in response to Item 1(a) of Current  Report on Form 8-K
pursuant  to Section  13 or 15(d) of the  Securities  Exchange  Act of 1934 (the
"Exchange  Act"),  (ii) any "person" (as such term is used in Sections 13(d) and
14(d) of the Exchange Act) is or becomes the  "beneficial  owner" (as defined in
Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the
Company  representing  20% or more of the combined voting power of the Company's
then  outstanding  securities,  or (iii) at any time individuals who were either
nominated for election or elected by the Board of Directors of the Company cease
for any reason to constitute at least a majority of the Board.

         If the Company  wrongfully  terminates the employment  agreement or Mr.
Gordon terminates the employment agreement for Good Reason, then (i) the Company
is required to pay Mr. Gordon his full salary through the termination date; (ii)
the Company is required to pay as severance pay to Mr. Gordon an amount equal to
(a) Mr. Gordon's average annual cash  compensation  received from the Company or
GP  Strategies  Corporation  during the three full  calendar  years  immediately
preceding the termination date,  multiplied by (b) the greater of (I) the number
of years  (including  partial  years)  that  would  have been  remaining  in the
employment  period if the  employment  agreement had not so terminated  and (II)
three,  such  payment  to be made (c) if  termination  is  based on a change  of
control of the Company,  in a lump sum on or before the fifth day  following the
termination  date  or (d) if  termination  results  from  any  other  cause,  in
substantially  equal semimonthly  installments  payable over the number of years
(including  partial  years)  that would have been  remaining  in the  employment
period if the employment  agreement had not so terminated;  (iii) all options to
purchase the  Company's  common stock  granted to Mr. Gordon under the Company's
option plan or otherwise  immediately  become fully vested and terminate on such
date as they would have terminated if Mr. Gordon's employment by the Company had
not terminated and, if Mr. Gordon's  termination is based on a change of control
of the Company and Mr.  Gordon elects to surrender any or all of such options to
the Company,  the Company is required to pay Mr.  Gordon a lump sum cash payment
equal to the excess of (a) the fair market value on the termination  date of the
securities  issuable  upon  exercise  of the  options  surrendered  over (b) the
aggregate exercise price of the options surrendered;  and (iv) if termination of
the employment  agreement arises out of a breach by the Company,  the Company is
required  to pay all other  damages  to which Mr.  Gordon may be  entitled  as a
result of such breach. If the employment  agreement is terminated for any reason
other than Cause,  the Company is required to maintain in full force and effect,
for a number of years equal to the greater of (i) the number of years (including
partial years) that would have been  remaining in the  employment  period if the
employment  agreement had not so terminated and (ii) three, all employee benefit
plans and programs in which Mr. Gordon was entitled to  participate  immediately
prior to the termination date.


<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.

                                               INTERFERON SCIENCES, INC.



                                            By: /s/ Lawrence M. Gordon

                                               ------------------------
                                               Lawrence M. Gordon
                                               Chief Executive Officer

Dated:  April 26, 2000




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