ADVANCED NEUROMODULATION SYSTEMS INC
SC 13D/A, 2000-04-12
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                       SECURITIES & EXCHANGE COMMISSION
                           Washington, D.C. 20549
                           ______________________

                                SCHEDULE 13D/A*
                                (Rule 13d-101)

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
           13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a)

                     Advanced Neuromodulation Systems, Inc.
                               (Name of Issuer)

                                 Common Stock
                        (Title of Class of Securities)

                                  00757T101
                                (CUSIP Number)

                              Douglas C. Floren
         600 Steamboat Road, Greenwich, Connecticut 06830 (203) 618-1601
                 (Name, address and telephone number of person
              authorized to receive notices and communications)

                                January 3, 2000
            (Date of event which requires filing of this statement)


     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box [ ].


     NOTE:  Schedules filed in paper format shall include a signed original
and five copies of the schedule, including all exhibits.  See Rule 13d-7 for
other parties to whom copies are to be sent.


                        (Continued on following pages)


                           (Page 1 of 15 Pages)
________________
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes)

CUSIP No. 00757T101                 13D/A                   Page 2 of 15 Pages

_____________________________________________________________________________
     (1)    NAME OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NOS.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           DCF Partners, L.P.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
_____________________________________________________________________________
     (3)    SEC USE ONLY
_____________________________________________________________________________
     (4)    SOURCE OF FUNDS **
                            WC
_____________________________________________________________________________
     (5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
            REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                        [ ]
_____________________________________________________________________________
     (6)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (7)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (8)  SHARED VOTING POWER
                                                 364,000
OWNED BY       ______________________________________________________________

EACH           (9)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (10) SHARED DISPOSITIVE POWER
                                                 364,000
_____________________________________________________________________________
     (11)    AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
                                                 364,000
_____________________________________________________________________________
     (12)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (11) EXCLUDES CERTAIN SHARES **                       [ ]
_____________________________________________________________________________
     (13)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (11)
                                                4.9%
_____________________________________________________________________________
     (14)    TYPE OF REPORTING PERSON **
                                                 PN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 00757T101                 13D/A                   Page 3 of 15 Pages

_____________________________________________________________________________
     (1)    NAME OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NOS.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           DCF Advisers, L.L.C.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
_____________________________________________________________________________
     (3)    SEC USE ONLY
_____________________________________________________________________________
     (4)    SOURCE OF FUNDS **
                            WC
_____________________________________________________________________________
     (5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
            REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]
_____________________________________________________________________________
     (6)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (7)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (8)  SHARED VOTING POWER
                                                 364,000
OWNED BY       ______________________________________________________________

EACH           (9)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (10) SHARED DISPOSITIVE POWER
                                                 364,000
_____________________________________________________________________________
     (11)    AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
                                                 364,000
_____________________________________________________________________________
     (12)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (11) EXCLUDES CERTAIN SHARES **                       [ ]
_____________________________________________________________________________
     (13)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (11)
                                                4.9%
_____________________________________________________________________________
     (14)    TYPE OF REPORTING PERSON **
                                                 OO
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 00757T101                 13D/A                   Page 4 of 15 Pages

_____________________________________________________________________________
     (1)    NAME OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NOS.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           DCF Capital, L.L.C.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
_____________________________________________________________________________
     (3)    SEC USE ONLY
_____________________________________________________________________________
     (4)    SOURCE OF FUNDS **
                           WC
_____________________________________________________________________________
     (5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
            REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]
_____________________________________________________________________________
     (6)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (7)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (8)  SHARED VOTING POWER
                                                250,000
OWNED BY       ______________________________________________________________

EACH           (9)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (10) SHARED DISPOSITIVE POWER
                                                250,000
_____________________________________________________________________________
     (11)    AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
                                                250,000
_____________________________________________________________________________
     (12)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (11) EXCLUDES CERTAIN SHARES **                       [ ]
_____________________________________________________________________________
     (13)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (11)
                                                 3.3%
_____________________________________________________________________________
     (14)    TYPE OF REPORTING PERSON **
                                                 IA
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 00757T101                 13D/A                   Page 5 of 15 Pages

_____________________________________________________________________________
     (1)    NAME OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NOS.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                                  Douglas C. Floren
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
_____________________________________________________________________________
     (3)    SEC USE ONLY
_____________________________________________________________________________
     (4)    SOURCE OF FUNDS **
                                   WC
_____________________________________________________________________________
     (5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
            REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                      [ ]
_____________________________________________________________________________
     (6)    CITIZENSHIP OR PLACE OF ORGANIZATION
                              United States
_____________________________________________________________________________
NUMBER OF     (7)  SOLE VOTING POWER
                                                12,500
SHARES         ______________________________________________________________

BENEFICIALLY   (8)  SHARED VOTING POWER
                                                614,000
OWNED BY       ______________________________________________________________

EACH           (9)  SOLE DISPOSITIVE POWER
                                                12,500
REPORTING      ______________________________________________________________

PERSON WITH    (10) SHARED DISPOSITIVE POWER
                                                614,000
_____________________________________________________________________________
     (11)    AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
                                                626,500
_____________________________________________________________________________
     (12)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (11) EXCLUDES CERTAIN SHARES **                       [ ]
_____________________________________________________________________________
     (13)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (11)
                                                8.4%
_____________________________________________________________________________
     (14)    TYPE OF REPORTING PERSON **
                                                 IN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 00757T101                 13D/A                   Page 6 of 15 Pages

_____________________________________________________________________________
     (1)    NAME OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NOS.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                                  Lance Willsey, M.D.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [X]
                                                                  (b)  [ ]
_____________________________________________________________________________
     (3)    SEC USE ONLY
_____________________________________________________________________________
     (4)    SOURCE OF FUNDS **
                                   WC
_____________________________________________________________________________
     (5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
            REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                      [ ]
_____________________________________________________________________________
     (6)    CITIZENSHIP OR PLACE OF ORGANIZATION
                              United States
_____________________________________________________________________________
NUMBER OF     (7)  SOLE VOTING POWER
                                                31,100
SHARES         ______________________________________________________________

BENEFICIALLY   (8)  SHARED VOTING POWER
                                                   -0-
OWNED BY       ______________________________________________________________

EACH           (9)  SOLE DISPOSITIVE POWER
                                                31,100
REPORTING      ______________________________________________________________

PERSON WITH    (10) SHARED DISPOSITIVE POWER
                                                   -0-
_____________________________________________________________________________
     (11)    AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON
                                                31,100
_____________________________________________________________________________
     (12)    CHECK BOX IF THE AGGREGATE AMOUNT
             IN ROW (11) EXCLUDES CERTAIN SHARES **                       [ ]
_____________________________________________________________________________
     (13)    PERCENT OF CLASS REPRESENTED
             BY AMOUNT IN ROW (11)
                                                0.4%
_____________________________________________________________________________
     (14)    TYPE OF REPORTING PERSON **
                                                 IN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 00757T101                 13D/A                   Page 7 of 15 Pages

Item 1.     Security and Issuer.

     The Schedule 13D (the "Schedule 13D") initially filed on October 12, 1999
by DCF Partners, L.P. ("DCF Partners"), DCF Advisers, L.L.C. ("DCF Advisers"),
DCF Capital, L.L.C. ("DCF Capital") and Mr. Douglas C. Floren ("Mr. Floren")
relating to the common stock with $.05 par value (the "Common Stock") of
Advanced Neuromodulation Systems, Inc. (the "Company"), whose principal
executive offices are located at 6501 Windcrest Drive, Plano, Texas 75024, is
hereby amended and restated by this Amendment No. 1 to the Schedule 13D.

Item 2.     Identity and Background.

     (a)  This statement is filed by:
          (i) DCF Partners, a Delaware limited partnership, with respect to
              the shares of Common Stock directly owned by it;
         (ii) DCF Advisers, a Delaware limited liability company, with respect
              to the shares of Common Stock directly owned by DCF Partners;
        (iii) DCF Capital, a Delaware limited liability company, which serves
              as investment manager to The DCF Life Sciences Fund Limited
              ("DCF Life Sciences"), a company organized under the laws of
              Bermuda, and to a separate managed account (the "Managed
              Account");
         (iv) Mr. Floren with respect to the shares of Common Stock directly
              owned by each of DCF Partners, DCF Life Sciences, the Managed
              Account and Mr. Floren.  The number of shares of Common Stock
              beneficially owned by Mr. Floren reflects shares held in certain
              trusts for the benefit of family members of Mr. Floren.
              Mr. Floren serves as the trustee of such trusts, and as such
              may be deemed the beneficial owner of the shares of Common Stock
              held by such trusts.  Mr. Floren has dispositive and voting
              power over the shares of Common Stock held by such trusts.
          (v) Lance Willsey, M.D. ("Dr. Willsey") with respect to the shares of
              Common Stock directly owned by Dr. Willsey.

                     The foregoing persons are hereinafter sometimes
              collectively referred to as the "Reporting Persons."  Any
              disclosures herein with respect to persons other than the
              Reporting Persons are made on information and belief after
              making inquiry to the appropriate party.

     (b)     The address of the principal business and principal office of DCF
Partners, DCF Advisers and DCF Capital is 660 Steamboat Road, Greenwich,
Connecticut 06830.  The business address of Mr. Floren and of Dr. Willsey is
660 Steamboat Road, Greenwich, Connecticut 06830.

     (c)     The principal business of DCF Partners is serving as a private
investment limited partnership investing primarily in the life sciences
industry.  The principal business of DCF Advisers is serving as general partner
to DCF Partners.  The principal business of DCF Capital is that of an
investment manager engaging in the purchase and sale of securities on behalf of
clients.  Mr. Floren serves as managing member of DCF Advisers and DCF Capital.
Dr. Willsey serves as non-managing member of DCF Advisers and DCF Capital.

     (d)     None of the Reporting Persons has, during the last five years,
been convicted in a criminal proceeding (excluding traffic violations or
similar misdemeanors).

CUSIP No. 00757T101                 13D/A                   Page 8 of 15 Pages

     (e)    None of the Reporting Persons has, during the last five years, been
a party to a civil proceeding of a judicial or administrative body of competent
jurisdiction and, as a result of such proceeding, was or is subject to, a
judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

     (f)    DCF Partners is a limited partnership organized under the laws of
the State of Delaware.  DCF Advisers and DCF Capital are limited liability
companies organized under the laws of the State of Delaware.  Mr. Floren and
Dr. Willsey are United States citizens.

Item 3.     Source and Amount of Funds and Other Consideration.

     The net investment cost (including commissions, if any) of the shares of
Common Stock directly owned by DCF Partners, DCF Life Sciences, the Managed
Account and Dr. Willsey is approximately $1,162,132, $996,884, $451,117 and
$161,105, respectively.  Neither DCF Advisers nor DCF Capital owns directly
any shares of Common Stock.

       The shares of Common Stock purchased by DCF Partners, DCF Life Sciences,
the Managed Account and Dr. Willsey were purchased with working capital.

Item 4.     Purpose of the Transaction.

     The purpose of the acquisition of the shares of Common Stock by the
Reporting Persons is for investment, and the purchases of the shares of Common
Stock by the Reporting Persons were made in the ordinary course of business and
were not made for the purpose of acquiring control of the Company.  Although
the acquisition of the shares of Common Stock by the Reporting Persons is for
investment purposes, the Reporting Persons may pursue discussions with
management to maximize long-term value for shareholders.  Each of the Reporting
Persons may make further purchases of shares of Common Stock from time to time
and may dispose of any or all of the shares of Common Stock held by him or it
at any time.  None of the Reporting Persons has any plans or proposals which
relate to, or could result in, any of the matters referred to in paragraphs (b)
through (j), inclusive, of Item 4 of Schedule 13D.  Each of the Reporting
Persons may, at any time and from time to time, review or reconsider his or its
position and formulate plans or proposals with respect thereto, but has no
present intention of doing so.

CUSIP No. 00757T101                 13D/A                   Page 9 of 15 Pages

Item 5.     Interest in Securities of the Issuer.

A. DCF Partners, L.P.
              (a) Aggregate number of shares beneficially owned: 364,000
                         Percentage: 4.9%  The percentages used herein and in
the rest of this Item 5 are calculated based upon the 7,470,867 shares of
Common Stock issued and outstanding as of April 7, 2000, as learned from the
Company's Chief Financial Officer by telephone on April 7, 2000.
              (b)(1) Sole power to vote or direct vote: -0-
                 (2) Shared power to vote or direct vote: 364,000
                 (3) Sole power to dispose or direct the disposition: -0-
                 (4) Shared power to dispose or direct the disposition: 364,000
              (c) The trading dates, number of shares of Common Stock purchased
or sold and the price per share for all transactions by DCF Partners in the
Common Stock since the filing of the Schedule 13D, which were all in the open
market, are set forth in Schedule A and are incorporated by reference.
              (d) DCF Advisers, the general partner of DCF Partners, has the
power to direct the affairs of DCF Partners, including decisions respecting the
receipt of dividends from, and the disposition of the proceeds from the sale
of, the Common Stock.  Mr. Floren is the Managing Member of DCF Advisers and in
that capacity directs its operations.
              (e) Not Applicable.

B.  DCF Advisers, L.L.C.
              (a) Aggregate number of shares beneficially owned: 364,000
                         Percentage: 4.9%
              (b)(1) Sole power to vote or direct vote: -0-
                 (2) Shared power to vote or direct vote: 364,000
                 (3) Sole power to dispose or direct the disposition: -0-
                 (4) Shared power to dispose or direct the disposition: 364,000
              (c) DCF Advisers did not enter into any transactions in the
Common Stock of the Company since the filing of the Schedule 13D.  The trading
dates, number of shares of Common Stock purchased or sold and the price per
share for all transactions in the Common Stock on behalf of DCF Partners since
the filing of the Schedule 13D, which were all in the open market, are set
forth in Schedule A and are incorporated by reference.
              (d)  Not applicable.
              (e)  Not applicable.

      C. DCF Capital, L.L.C.
              (a) Aggregate number of shares beneficially owned: 250,000
                         Percentage: 3.3%
              (b)(1) Sole power to vote or direct vote: -0-
                 (2) Shared power to vote or direct vote: 250,000
                 (3) Sole power to dispose or direct the disposition: -0-
                 (4) Shared power to dispose or direct the disposition: 250,000
              (c) DCF Capital did not enter into any transactions in the Common
Stock of the Company since the filing of the Schedule 13D.  The trading dates,
number of shares of Common Stock purchased or sold and the price per share for
all transactions in the Common Stock on behalf of clients since the filing of
the Schedule 13D, which were all in the open market, are set forth in Schedule
B and are incorporated by reference.

CUSIP No. 00757T101                 13D/A                  Page 10 of 15 Pages

              (d) Each of the clients of DCF Capital has the power to direct
the receipt of dividends from or the proceeds of sale of the Common Stock.
              (e) Not Applicable.

       D. Douglas C. Floren.
             (a) Aggregate number of shares beneficially owned: 626,500
                       Percentage:  8.4%
             (b)(1)  Sole power to vote or direct vote: 12,500
                (2)  Shared power to vote or direct vote: 626,500
                (3)  Sole power to dispose or direct the disposition: 12,500
                (4)  Shared power to dispose or direct the disposition: 626,500
             (c) Mr. Floren did not enter into any transactions in the Common
Stock of the Company since the filing of the Schedule 13D.  The trading dates,
number of shares of Common Stock purchased or sold and the price per share for
all transactions in the Common Stock on behalf of DCF Partners since the filing
of the Schedule 13D, which were all in the open market, are set forth in
Schedule A and are incorporated by reference.  The trading dates, number of
shares of Common Stock purchased or sold and the price per share for all
transactions in the Common Stock on behalf of DCF Life Sciences and the Managed
Account since the filing of the Schedule 13D, which were all in the open
market, are set forth in Schedule B and are incorporated by reference.
             (d)  Not applicable.
             (e)  Not applicable.


       E. Lance Willsey, M.D.
             (a) Aggregate number of shares beneficially owned: 31,100
                       Percentage:  0.4%
             (b)(1)  Sole power to vote or direct vote: -0-
                (2)  Shared power to vote or direct vote: 31,100
                (3)  Sole power to dispose or direct the disposition: -0-
                (4)  Shared power to dispose or direct the disposition: 31,100
             (c) The trading dates, number of shares of Common Stock purchased
or sold and the price per share for all transactions in the Common Stock by Dr.
Willsey since the filing of the Schedule 13D, which were all in the open
market, are set forth in Schedule C, and are incorporated by reference.
             (d)  Not applicable.
             (e)  Not applicable.


Item 6.     Contracts, Arrangements, Understandings or
            Relationships with Respect to Securities of the Issuer.

     Other than the Joint Acquisition Statement attached as Exhibit 1 hereto,
there are no contracts, arrangements, understandings or relationships (legal or
otherwise) among the persons named in Item 2 hereof and between such persons
and any person with respect to any securities of the Company, including but not
limited to transfer or voting of any other securities, finder's fees, joint
ventures, loan or option arrangements, puts or calls, guarantees of profits,
divisions of profits or loss, or the giving or withholding of proxies.


Item 7.     Materials to be Filed as Exhibits.

     There is filed herewith as Exhibit 1 a written agreement relating to the
filing of joint acquisition statements as required by Rule 13d-1(k)(1) under
the Securities Exchange Act of 1934, as amended.


CUSIP No. 00757T101                 13D/A                  Page 11 of 15 Pages

SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.


DATED:  April 12, 2000

                                    /s/ DOUGLAS C. FLOREN
                                    ----------------------
                                    Douglas C. Floren, individually, and as
                                    managing member of
                                    DCF Advisers, L.L.C.,
                                    general partner of
                                    DCF Partners, L.P.,
                                    and as managing member of
                                    DCF Capital, L.L.C.


                                    /s/ LANCE WILLSEY, M.D.
                                    -----------------------
                                    Lance Willsey, M.D.






























CUSIP No. 00757T101                 13D/A                  Page 12 of 15 Pages

                                  Schedule A

                             DCF PARTNERS, L.P.

                                                       Price Per Share
Date of                       Number of Shares         (including commissions,
Transaction                   Purchased/(Sold)         if any)

11/19/99                      25,000                   $ 7.56
02/09/00                       5,000                    15.00
03/02/00                      25,000                    17.44
03/03/00                      15,000                    18.56
03/06/00                      10,000                    18.38




CUSIP No. 00757T101                 13D/A                  Page 13 of 15 Pages

                                  Schedule B

                      DCF CAPITAL, L.L.C. - MANAGED ACCOUNTS

                                                          Price Per Share
Date of                             Number of Shares      (including
Transaction   Client                Purchased/(Sold)      commissions, if any)

11/19/99      the Managed Account   20,000                $ 7.56
11/19/99      DCF Life Sciences     15,000                  7.56
01/03/00      the Managed Account    5,000                 10.10
01/03/00      DCF Life Sciences     10,000                 10.10
01/06/00      DCF Life Sciences      5,000                 11.50
02/08/00      DCF Life Sciences     25,000                 15.09
02/09/00      the Managed Account    5,000                 15.00
02/09/00      DCF Life Sciences      5,000                 15.00
03/02/00      the Managed Account   10,000                 17.44
03/02/00      DCF Life Sciences      5,000                 17.44
03/03/00      DCF Life Sciences     10,000                 18.56







CUSIP No. 00757T101                 13D/A                  Page 14 of 15 Pages

                                  Schedule C

                             LANCE WILLSEY, M.D.

                                                       Price Per Share
Date of                       Number of Shares         (including commissions,
Transaction                   Purchased/(Sold)         if any)

12/06/99                       1,000                   $6.94
12/13/99                         100                    7.94
12/20/99                       5,000                    9.00
12/22/99                      10,000                    9.00
12/29/99                       2,000                    9.19




CUSIP No. 00757T101                 13D/A                  Page 15 of 15 Pages

                                     EXHIBIT 1

                              JOINT ACQUISITION STATEMENT
                               PURSUANT TO RULE 13D-1(k)1


The undersigned acknowledge and agree that the foregoing statement on Schedule
13D is filed on behalf of each of the undersigned and that all subsequent
amendments to this statement on Schedule 13D, shall be filed on behalf of each
of the undersigned without the necessity of filing additional joint
acquisition statements.  The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him or it contained therein, but
shall not be responsible for the completeness and accuracy of the information
concerning the others, except to the extent that he or it knows or has reason
to believe that such information is inaccurate.


Dated:  April 12, 2000

                                    /s/ DOUGLAS C. FLOREN
                                    ----------------------
                                    Douglas C. Floren, individually, and as
                                    managing member of
                                    DCF Advisers, L.L.C.,
                                    general partner of
                                    DCF Partners, L.P.,
                                    and as managing member of
                                    DCF Capital, L.L.C.



                                    /s/ LANCE WILLSEY, M.D.
                                    -----------------------
                                    Lance Willsey, M.D.




























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