RIBI IMMUNOCHEM RESEARCH INC
4, 1998-01-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                           OMB APPROVAL        
                                                    ---------------------------
- ------                                              OMB Number:   3235-0287    
FORM 4                                              Expires:  April 30, 1998   
- ------                                              Estimated average burden   
                                                    hours per response .... 0.5
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                                 U.S. SECURITIES AND EXCHANGE COMMISSION
                                          WASHINGTON, D.C. 20549
                                       
                               STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
/ / Check this box if no                                                     
    longer subject to         Filed pursuant to Section 16(a) of the Securities 
    Section 16. Form 4            Exchange Act of 1934, Section 17(a) of the 
    or Form 5 obligations         Public Utility Holding Company Act of 1935
    may continue. See              or Section 30(f) of the Investment Company
    Instruction 1(b).                           Act of 1940               

<TABLE> 
<S>                             <C>            <C>                        <C>                <C>          <C>            <C>   
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 1. Name and Address of Reporting Person*      2. Issuer Name and Ticker or Trading Symbol   6. Relationship of Reporting Persons to
S.R. ONE, LIMITED                              RIBI IMMUNOCHEM RESEARCH, INC. (RIBI)            Issuer (Check all applicable)
- ---------------------------------------------------------------------------------------------       Director      X  10% Owner
  (Last)          (First)          (Middle)    3. IRS or Social Security  4. Statement for      ----              ---
BAY COLONY EXECUTIVE PARK                         Number of Reporting        Month/Year             Officer (give    Other (Specify
565 E. SWEDESFORD ROAD                            Person (Voluntary)      DECEMBER 1997         ----        title ---       below)
- ---------------------------------------------     23-1729901              -------------------               below)
                 (Street)                                                 5. If Amendment,    7. Individual or Joint Group Filing
SUITE 315                                                                    Date of Original    (Check Applicable)
WAYNE                      PA 19087                                          (Month/Year)        Form filed by One Reporting Person
                                                                                              ---
                                                                                               X Form filed by more than One
                                                                                              ---Reporting Person
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  (City)           (State)           (Zip)     TABLE I -- NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
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 1. Title of Security           2. Trans-   3. Transac-  4. Securities Acquired (A)  5.  Amount of Se-    6. Owner-      7. Nature  
  (Instr. 3)                       action      tion         or Disposed of (D)           curities Benefi-    ship           of In-  
                                   Date        Code         (Instr. 3, 4 and 5)          cially Owned at     Form:          direct  
                                               (Instr. 8)                                End of Month        Direct         Benefi-
                                  (Month/                                                (Instr. 3 and 4)    (D) or         cial
                                   Day/   ---------------------------------------                            Indirect       Owner- 
                                   Year)  Code    V      Amount   (A) or    Price                            (I)            ship   
                                                                  (D)                                        (Instr. 4)     (Instr.
                                                                                                                            4)     

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COMMON STOCK                     12/16/97  S             10,000    D         $4.0000                            D
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COMMON STOCK                     12/17/97  S             32,000    D         $4.0000                            D
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COMMON STOCK                     12/18/97  S             10,000    D         $4.0000                            D
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COMMON STOCK                     12/19/97  S              2,000    D         $4.0000           693,608          D
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COMMON STOCK                                                                                 1,103,448          I        BY
                                                                                                                         CORPORATION
                                                                                                                         (1)
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Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                   (Over)
*If the form filed by more than one reporting person, see Instruction for (b)(v).
                                                                               (Print or Type Responses)             SEC 1474 (7/96)
 
</TABLE>

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<TABLE>
<CAPTION>
                                                                                                                                
 
FORM 4 (CONTINUED)        TABLE II -- DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
                                  (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)

<S>                       <C>          <C>        <C>         <C>              <C>             <C>                   <C>          
- ------------------------------------------------------------------------------------------------------------------------------------
1. Title of Derivative    2. Conver-   3. Trans-  4. Trans-   5. Number of     6. Date Exer-   7. Title and Amount   8. Price     
   Security                  sion or      action     action      Derivative       cisable and     of Underlying         of        
   (Instr. 3)                Exercise     Date       Code        Securities Ac-   Expiration      Securities            Deriv-    
                             Price of     (Month/    (Instr. 8)  quired (A) or    Date            (Instr. 3 and 4)      ative     
                             Deriv-       Day/                   Disposed of (D)  (Month/Day/                           Secur-    
                             ative        Year)                  (Instr. 3, 4,    Year)                                 ity       
                             Security                            and 5)                                                 (Instr. 5)
                                                                               -----------------------------------             
                                                                               Date    Expira-            Amount or            
                                                    -------------------------- Exer-   tion       Title   Number of            
                                                    Code  V     (A)     (D)    cisable Date               Shares               
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NON-QUALIFIED STOCK OPTION     (2)                                                                 COMMON    (2)
(RIGHT TO BUY)                                                                 12/31/96 12/31/98   STOCK   551,724
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WARRANT TO PURCHASE COMMON                                                                         COMMON  
SHARES                         $5.0000                                         12/31/96 12/31/99   STOCK   500,000
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<S>                          <C>                    <C>                         <C>                              
1. Title of Derivative       9. Number of           10. Ownership               11. Nature of                              
   Security                     Derivative              Form of                     Indirect                     
   (Instr. 3)                   Securities              Derivative                  Beneficial                   
                                Beneficially            Security:                   Ownership                    
                                Owned at End            Direct (D)                  (Instr. 4)                   
                                of Month                or Indirect (I)                                          
                                (Instr. 4)              (Instr. 4)                                               
                                                                                 
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                                (2)                                                 BY CORPORATION
                                551,724                      I                      (1)
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                                                                                    BY CORPORATION
                                500,000                      I                      (1)
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<CAPTION>
Explanation of Responses:
 
(1) Owned of record by SmithKline Beecham Biologicals Manufacturing S.A. ("SBBM"), an affiliate of Reporting Person, both of which
    are under common control as subsidiaries of SmithKline Beecham Corporation.

(2) 551,724 shares (based on the Subsequent Market Price for the Common Stock at December 31, 1996) which SBBM has right to acquire
    by exercise of a stock option (expiring December 31, 1998). The stock option granted by the Issuer gives SBBM the right to
    acquire up to $2,000,000 in Common Stock at Subsequent Market Price defined in the underlying agreement as the average of the
    mean of the high and low prices for the Common Stock as reported on the NASDAQ National Market tier of the NASDAQ Stock Market
    for each of the five (5) consecutive trading days ending two (2) days prior to the closing date for the option exercise.

<S>                                                                            <C>                                <C>
**Intentional misstatements or omissions of facts 
  constitute Federal Criminal Violations.                                        /s/ DONALD F. PARMAN             JANUARY 9, 1998
  See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).                                    -------------------------------    ---------------
                                                                               **Signature of Reporting Person          Date     
                                                                               BY: DONALD F. PARMAN, SECRETARY                   
                                                                               FOR: S.R. ONE, LIMITED                            

Note: File three copies of this Form, one of which must be manually signed.                                                        
      If space provided is insufficient, see Instruction 6 for procedure.                                                          
Potential persons who are to respond to the collection of information
contained in this form are not required to respond unless the                                                                 Page 2
form displays the currently valid OMD Number.                                                                        SEC 1474 (7/96)
</TABLE>                                                                      




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