UNIGENE LABORATORIES INC
S-8 POS, 1995-06-22
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                                               Page 1 of 6 Pages

                                                       Registration No. 33-18890

                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                     * * *

                         POST-EFFECTIVE AMENDMENT NO. 6
                                       TO
                                    FORM S-8

                        REGISTRATION STATEMENT UNDER THE
                             SECURITIES ACT OF 1933

                                     * * *

                           UNIGENE LABORATORIES, INC.
               --------------------------------------------------
               (Exact name of issuer as specified in its charter)


          Delaware                                               22-2328609
- ---------------------------------                            -------------------
(State or other jurisdiction                                 (I.R.S. Employer
of incorporation or organization)                            Identification No.)


               110 Little Falls Road, Fairfield, New Jersey 07004
              ---------------------------------------------------
              (Address of Principal Executive Offices) (Zip Code)


                             1984 STOCK OPTION PLAN
                            ------------------------
                            (Full title of the plan)


                              JESSE MARGOLIN, ESQ.
                      Becker Ross Stone DeStefano & Klein
                        317 Madison Avenue - Suite #1410
                         New York, New York 10017-5372
                    --------------------------------------- 
                    (Name and address of agent for service)

                                 (212) 697-2310
         -------------------------------------------------------------
         (Telephone number, including area code, of agent for service)

                                  Cover Page 1
<PAGE>
                                                               Page 2 of 6 Pages
                                    PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3. Incorporation of Documents by Reference.


         The  following  documents  previously  filed  with the  Securities  and
Exchange Commission (the "Commission") are hereby incorporated by reference into
this Registration Statement:

         A. The Annual Report of Unigene Laboratories, Inc. (the "Registrant" or
the "Company") for the year ended December 31, 1994.

         B. The  Company's  Quarterly  Report on Form 10Q for the  period  ended
March 31, 1995.

         C. The description of the Registrant's Common Stock, $.01 par value, as
set forth in Item 1 of the Registrant's Registration Statement on Form 8-A (File
No.  0-16005)  filed  with the  Commission  on August  4, 1987 and which  became
effective on August 12, 1987.

         All  documents  filed  subsequent  to the  date  of  this  Registration
Statement  pursuant  to Section  13(a),  13(c),  14 and 15(d) of the  Securities
Exchange Act of 1934 prior to the filing of a  post-effective  amendment to this
Registration  Statement  which  indicates that all securities  offered have been
sold or which  deregisters all securities then remaining  unsold shall be deemed
to be incorporated by reference in this Registration  Statement and to be a part
thereof from the date of filing such documents.


Item 4. Description of Securities.


         Not Applicable.


Item 5. Interests of Named Experts and Counsel.


         None.


Item 6. Indemnification of Directors and Officers.

         Section  145 of the  General  Corporation  Law of the State of Delaware
provides for  indemnification  of directors and officers and other  employees or
agents of the  Company.  Such a person must be  indemnified  to the extent he is
successful  on  the  merits  or  otherwise  in a  legal  proceeding.  He  may be
indemnified  in a third party or  derivative  suit if he acted in good faith and
for a purpose he reasonably believed was in or not opposed to the best interests
of the  Company,  and  if,  in the  case  of a  criminal  proceeding,  he had no
reasonable cause to believe his conduct was unlawful.  A director or officer may
not be indemnified in a derivative  suit for amounts paid to settle such a suit,
<PAGE>
                                                               Page 3 of 6 Pages

and he may not be indemnified  for his legal  expenses if he is adjudged  liable
for  negligence  or misconduct  in his  performance  of his duty to the Company,
except by court order.

         Article VI of the Company's  By-Laws  requires the Company to indemnify
each of its  directors  and officers to the fullest  extent  permitted by law in
connection with any actual or threatened action or proceeding arising out of his
service to the Company or to other organizations at the Company's request.

         Section 7 of the Plan  provides  that the members of the Board shall be
indemnified by the Company against all costs and expenses reasonably incurred by
them in connection  with any action,  suit or proceeding to which they or any of
them may be a party by reason of any action  taken or failure to act under or in
connection  with the Plan,  or any option  granted  thereunder,  and against all
amounts paid by them in settlement thereof (provided such settlement is approved
by legal counsel  selected by the Company) or paid by them in  satisfaction of a
judgment in any such action, suit or proceeding,  except a judgment based upon a
finding of bad faith.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers or persons  controlling the
registrant  pursuant  to the  foregoing  provisions,  the  registrant  has  been
informed  that in the opinion of the  Securities  and Exchange  Commission  such
indemnification  is  against  public  policy  as  expressed  in the  Act  and is
therefore unenforceable.


Item 7. Exemption from Registration Claimed.


         In August  1986,  an  aggregate  of 231,822  shares of Common  Stock of
Unigene  Laboratories,  Inc.  was  sold to 15  non-affiliated  employees  of the
Company for an aggregate of $37,136  pursuant to the exercise of options granted
under the  Company's  1984 Stock Option  Plan.  The issuance of these shares was
made in  reliance on the  exemption  from  registration  provided by Rule 504 of
Regulation D under the Securities Act of 1933. A Form D with respect thereto was
filed with the Securities and Exchange  Commission on August 25, 1986.  Although
such shares were included in this Registration  Statement for reoffer or resale,
such  transactions  effected on or after  September 1989 have been, and will be,
made in reliance upon the exemption from registration provided by Rule 144(k).
<PAGE>
                                                               Page 4 of 6 Pages
Item 8. Exhibits.


         4.       -        Specimen Certificate for Common Stock, par value
                           $.01 per share.  Incorporated by reference to
                           Exhibit 4.2 in Registration Statement No. 33-6877
                           on Form S-1.

        *5.       -        Opinion of Becker Ross Stone DeStefano & Klein as
                           to the legality of the shares being registered.

       *23.       -        Consent of Becker Ross Stone DeStefano & Klein
                           (included in Exhibit 5 to this Registration
                           Statement).

       23.1       -        Consent of KPMG Peat Marwick LLP.  Incorporated by
                           reference to consent set forth on page 28 of
                           Registrant's Annual Report for the year ended
                           December 31, 1994 on Form 10-K.

      *28.        -        Statement Regarding Unregistered Securities Issued
                           Pursuant to the Plan.


Item 9. Undertakings.


         The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

                  (a) To include any prospectus  required by Section 10(a)(3) of
the Securities Act of 1933;

                  (b) To reflect in the  prospectus  any facts or events arising
after the  effective  date of the  Registration  Statement  (or the most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental  change in the information set forth in the Registration
Statement;

                  (c) To include any  material  information  with respect to the
plan of distribution not previously  disclosed in the Registration  Statement or
any material change to such information in the Registration Statement;


- --------------------------
* Previously filed.
<PAGE>
                                                               Page 5 of 6 Pages

                  Provided,  however,  that paragraphs  (1)(a) and (1)(b) do not
apply if the information  required to be included in a post-effective  amendment
by those  paragraphs is contained in periodic  reports  filed by the  Registrant
pursuant to Section 13 or Section 15(d) of the  Securities  Exchange Act of 1934
that are incorporated by reference in this Registration Statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new Registration Statement relating to the securities offered therein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         The  undersigned  Registrant  hereby  undertakes  that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
Registrant's  Annual  Report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
Registration  Statement  shall  be  deemed  to be a new  Registration  Statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers and controlling  persons of
the  Registrant  pursuant  to  the  foregoing  provisions,   or  otherwise,  the
Registrant  has been advised that in the opinion of the  Securities and Exchange
Commission,  such  indemnification  is against public policy as expressed in the
Act  and  is,  therefore,   unenforceable.   In  the  event  that  a  claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.
<PAGE>
                                                               Page 6 of 6 Pages

                                   SIGNATURES


         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement or amendment to be signed on its behalf by the undersigned,  thereunto
duly authorized, in the City of New York, State of New York, on June 20, 1995.


                                                    UNIGENE LABORATORIES, INC.


                                                    By S/WARREN P. LEVY
                                                       -------------------------
                                                       Warren P. Levy, President


         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the date indicated.

<TABLE>
<CAPTION>
Signature                                   Title                                                Date
- ---------                                   -----                                                ----
<S>                                         <C>                                                  <C>  
S/WARREN P. LEVY                            Director; President                                  June 20, 1995
- -------------------                         (Chief Executive Officer)
Warren P. Levy     


S/RONALD S. LEVY                            Director; Vice President                             June 20, 1995
- -------------------                         (Chief Operating Officer)
Ronald S. Levy     


S/JAY LEVY                                  Chairman of the Board of                             June 20, 1995
- -------------------                         Directors; Treasurer                                              
Jay Levy                                    (Chief Financial and
                                            Chief Accounting Officer)
                   


S/ROBERT G. RUARK                           Director                                             June 20, 1995
- -------------------                                                                                           
Robert G. Ruark


S/GEORGE M.WEIMER                           Director                                             June 20, 1995
- -------------------                                                                                           
George M. Weimer
</TABLE>




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