UNIGENE LABORATORIES INC
DEF 14A, 1999-05-19
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                           Unigene Laboratories, Inc.
                              110 Little Falls Road
                           Fairfield, New Jersey 07004
                                 (973) 882-0860



                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           To be held on June 23, 1999

     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders  of Unigene
Laboratories,  Inc., a Delaware corporation (the "Company"), will be held at the
offices of the Company, 83 Fulton Street,  Boonton, New Jersey 07005 on June 23,
1999, at 11:00 A.M., Eastern Daylight Time, for the following purposes:

     1.   To elect directors of the Company;

     2.   To approve the adoption of the Company's  Directors Stock Option Plan;

     3.   To ratify the appointment of KPMG LLP as auditors of the Company; and

     4.   To  transact  such other  business  as may  properly  come  before the
          meeting and any adjournment thereof.

     The Board of Directors  has fixed the close of business on May 3, 1999,  as
the record date for the determination of stockholders who are entitled to notice
of and to vote at the meeting.
   
     A copy of the Company's  Annual Report for the year ended December 31, 1998
is sent to you along with the Proxy Statement.

     To assure your representation at the meeting,  please sign, date and return
your proxy in the enclosed envelope,  which requires no postage if mailed in the
United States.
                                              By Order of the Board of Directors

                                              /s/ RONALD S. LEVY
                                              ----------------------------------
                                              RONALD S. LEVY
                                              Secretary

May 14, 1999
<PAGE>
                                    Unigene

                           Unigene Laboratories, Inc.
                              110 Little Falls Road
                           Fairfield, New Jersey 07004
                                 (973) 882-0860

                                 PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS

     This Proxy  Statement is furnished in connection  with the  solicitation of
proxies by the Board of  Directors  of Unigene  Laboratories,  Inc.,  a Delaware
corporation  (the  "Company"),  for the Annual  Meeting of  Stockholders  of the
Company to be held at the offices of the Company, 83 Fulton Street, Boonton, New
Jersey 07005, on June 23, 1999, at 11:00 A.M., Eastern Daylight Time.
     You are requested to complete, date and sign the accompanying form of proxy
and return it to the Company in the enclosed envelope.  The proxy may be revoked
at any time before it is  exercised by written  notice to the Company  bearing a
later date than the date on the proxy,  provided  such notice is received by the
Company prior to the start of the meeting. Any stockholder attending the meeting
may vote in person  whether or not he or she has  previously  submitted a proxy.
Where  instructions  are  indicated,  a duly  executed  proxy  will be  voted in
accordance with such instructions.  Where no instructions are indicated,  a duly
executed proxy will be voted for each of the director  nominees named herein and
in favor of each of the proposals set forth in the attached Notice.
     The Board of Directors  has fixed the close of business on May 3, 1999,  as
the record date (the "Record Date") for the  determination  of stockholders  who
are entitled to notice of and to vote at the meeting. As of the Record Date, the
outstanding  shares of the Company  entitled to vote were  40,122,421  shares of
common stock,  par value $.01 per share ("Common  Stock"),  the holders of which
are entitled to one vote per share.
     A majority of the outstanding shares of Common Stock,  present in person or
represented  by proxy,  will  constitute a quorum for the conduct of business at
the Annual Meeting.  Directors will be elected by a plurality of the votes cast.
The affirmative  vote of a majority of the votes present and entitled to vote at
the Annual Meeting is required for the approval of the adoption of the Company's
Directors Stock Option Plan and for the  ratification of the appointment of KPMG
LLP as auditors  of the  Company.  For matters  that  require for  adoption  the
affirmative  vote of a  majority  of the  shares of  Common  Stock  present  and
entitled to vote,  abstentions  are considered as shares present and entitled to
vote and, therefore,  have the effect of a no vote, whereas broker non-votes are
considered  shares not present  and  entitled  to vote and,  therefore,  have no
impact on the outcome of the vote.
     This  Proxy  Statement  and the  accompanying  Notice of Annual  Meeting of
Stockholders  and form of proxy are being mailed to the stockholders on or about
May 14, 1999. A copy of the Company's  Annual Report for the year ended December
31,1998, is also enclosed. 

                                  PRINCIPAL STOCKHOLDERS
 
The following  table sets forth  information  as of May 3, 1999,  concerning the
persons who are known by the Company to own beneficially  more than 5 percent of
the  outstanding  shares of Common Stock,  other than persons who are identified
under the heading "Security Ownership of Management".
<PAGE>
<TABLE>
<CAPTION>
      Name and Address of                 Amount of Beneficial               Percentage of
         Beneficial Owner                       Ownership                 Outstanding Shares
         ----------------                       ---------                 ------------------
<S>                                            <C>                               <C> 
      The Tail Wind Fund, Ltd. (1)             3,151,720                         7.4%
      Windermere House
      404 East Bay Street
      P.O. Box SS-5539
      Nassau, Bahamas

      Loews Corporation (2)                     3,000,000                        7.3%
      CNA Plaza
      Chicago, IL 60685
</TABLE>
                                       
<PAGE>
- ----------
(1)  Tail Wind is the holder of 5% Convertible  Debentures  that are convertible
     into  Common  Stock and  Warrants to  purchase  Common  Stock at a floating
     conversion  price that is tied to the market price of the Common Stock. The
     amount  and  percentage  of shares  shown as  beneficially  owned  includes
     462,605 shares of Common Stock; 26,620 shares of Common Stock issuable upon
     the exercise of Warrants;  and  2,662,495  shares of Common Stock  issuable
     upon (a) conversion of 5% Convertible Debentures in the principal amount of
     $1,800,000  and (b) exercise of Warrants  issuable  upon  conversion of the
     Debentures,  which  2,662,495  shares is the maximum number issuable within
     the next 60 days under the terms of the Debentures.  Tail Wind has reported
     that it has sole voting  power and sole  dispositive  power with respect to
     such shares.

(2)  Based on  information  furnished by Loews  Corporation  in a Schedule  13G,
     dated March 4, 1997,  filed with the Securities and Exchange  Commission in
     which it reports that the securities,  which consist of 2,000,000 shares of
     Common Stock and warrants to purchase 1,000,000 shares of Common Stock, are
     owned by  Continental  Casualty  Company,  which is owned by CNA  Financial
     Corp.,  a company in which Loews  Corporation  has an 84% equity  interest.
     Loews reports that it has sole voting power and sole dispositive power with
     respect to such shares.
<PAGE>

SECURITY OWNERSHIP OF MANAGEMENT
     The following  table sets forth  information as of May 3, 1999,  concerning
the beneficial  ownership of Common Stock by each director of the Company,  each
executive officer of the Company listed in the Summary  Compensation  Table, and
all directors and executive officers of the Company as a group.
<TABLE>
<CAPTION>
                 Name of                                     Amount and Nature of                     Percent of
            Beneficial Owner                               Beneficial Ownership (1)                      Class
            ----------------                               ------------------------                      -----
<S>                                                               <C>       <C>                           <C> 
            Warren P. Levy                                        1,980,545 (2)                           5.0%
            Ronald S. Levy                                        1,995,545 (2)                           5.0%
            Jay Levy                                                523,095                               1.3%
            Robert F. Hendrickson                                    35,000 (3)                           0.1%
            Allen Bloom                                              11,000 (4)                            --
            Robert G. Ruark                                          30,000 (5)                           0.1%
            Officers and Directors
              as a Group (7 persons)                              4,641,845 (2) (6)                      11.5%
</TABLE>
- ----------
(1)  Unless otherwise  noted,  each person or group has reported sole voting and
     sole  dispositive  power with respect to securities  shown as  beneficially
     owned by him.

(2)  Includes  200,000  shares of Common  Stock  held in a family  trust over on
     which Warren P. Levy and Ronald S. Levy in their capacity as trustees share
     voting and dispositive power.

(3)  Includes  20,000 shares of Common Stock that Mr.  Hendrickson has the right
     to acquire pursuant to stock options, which are exercisable immediately.

(4)  Includes  10,000  shares of Common  Stock  that Mr.  Bloom has the right to
     acquire pursuant to stock options which are exercisable immediately.

(5)  Consists  solely of shares of Common  Stock that Mr. Ruark has the right to
     acquire  pursuant to stock options which are exercisable  immediately.  Mr.
     Ruark,  a director of the Company,  is retiring from the Board prior to the
     1999 stockholders' meeting.

(6)  Includes an aggregate  of 302,000  shares of Common Stock that such persons
     have the right to acquire pursuant to stock options,  which are exercisable
     immediately.
<PAGE>
                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

     Five directors of the Company are to be elected at the Annual Meeting.  The
directors  will serve  until the Annual  Meeting of  Stockholders  to be held in
2000,  and  until  their  respective  successors  shall  have been  elected  and
qualified.
     Each of the persons  named below is currently a director of the Company and
each was elected as a director at the Company's  Annual Meeting of  Stockholders
in 1998. The Board of Directors of the Company has no reason to believe that any
of the nominees will be unavailable for election as a director.  However, should
any of them become  unwilling or unable to accept  nomination for election,  the
individuals  named  in the  enclosed  proxy  will  vote  for the  election  of a
substitute  nominee  selected by the Board of Directors or, if no such person is
nominated,  the Board of  Directors  will reduce the number of  Directors  to be
elected.
     The following table sets forth certain information with respect to the five
nominees.
                                      
<PAGE>
<TABLE>
<CAPTION>
                                                                                                  Served
                                                                                               Continuously
              Name                                                    Age                    as Director Since
              ----                                                    ---                    -----------------
<S>                          <C>                                      <C>                          <C> 
              Warren P. Levy (1)                                      47                           1980
              Ronald S. Levy (1)                                      50                           1980
              Jay Levy (1)                                            75                           1980
              Allen Bloom                                             55                           1998
              Robert F. Hendrickson                                   66                           1997
</TABLE>
- ----------

(1)  Dr.  Warren P. Levy and Dr. Ronald S. Levy are brothers and are the sons of
     Mr. Jay Levy.

     Dr.  Warren P. Levy,  a founder of the  Company,  has served as  President,
Chief  Executive  Officer and  Director of the Company  since its  formation  in
November 1980. Dr. Levy holds a Ph.D. in biochemistry and molecular biology from
Northwestern   University  and  a  bachelor's   degree  in  chemistry  from  the
Massachusetts Institute of Technology.

     Dr. Ronald S. Levy, a founder of the Company, has served as Director of the
Company since its formation in November 1980, as Executive Vice President  since
April 1999 and as Secretary  since May 1986.  From  November  1980 through March
1999,  he served as Vice  President  of the Company.  Dr. Levy holds a Ph.D.  in
bioinorganic  chemistry  from  Pennsylvania  State  University  and a bachelor's
degree in chemistry from Rutgers University.

     Mr. Jay Levy, a founder of the Company, has served as Chairman of the Board
of Directors and Treasurer of the Company since its formation in November  1980.
Mr. Levy is a part-time employee of the Company and devotes approximately 15% of
his time to the  Company.  From 1985  through  February  1991,  he served as the
principal  financial  advisor to the Estate of Nathan Cummings and its principal
beneficiary,   The  Nathan  Cummings   Foundation,   Inc.,  a  large  charitable
foundation. For the seventeen years prior thereto, he performed similar services
for the late Nathan Cummings, a noted industrialist and philanthropist.

     Dr. Allen Bloom, a patent  attorney,  has been a partner in Dechert Price &
Rhoads,  a law firm, for the past five years where he established  and heads the
patent  practice  group  which  focuses on  biotechnology,  pharmaceuticals  and
medical  devices.  For the nine  years  prior  thereto,  he was Vice  President,
General  Counsel and Secretary of The Liposome  Company,  Inc., a  biotechnology
company.  His responsibilities  there included patent,  regulatory and licensing
activities.  Dr.  Bloom  holds a Ph.D.  in  organic  chemistry  from Iowa  State
University.

     Mr. Robert F.  Hendrickson  was Senior Vice  President,  Manufacturing  and
Technology, for Merck & Co., Inc., an international pharmaceutical company, from
1985 to 1990. Since 1990, Mr. Hendrickson has been a management  consultant with
a number of biotechnology and pharmaceutical  companies among his clients. He is
currently a director of Envirogen, Inc. an environmental  biotechnology company,
and a director of Cytogen,  Inc. and The Liposome Co.,  Inc.,  both of which are
biotechnology companies.
<PAGE>
BOARD OF DIRECTORS AND COMMITTEES
     During 1998, there were five meetings of the Board of Directors.
     Several  important  functions of the Board of Directors may be performed by
committees  that  are  comprised  of  members  of the  Board of  Directors.  The
Company's  By-laws  authorize  the formation of these  committees  and grant the
Board the  authority  to  prescribe  the  functions  of each  committee  and the
standards  for  membership  of each  committee.  The  Board  has  four  standing
committees:  an  Audit  Committee,  a  Compensation  Committee,  a Stock  Option
Committee for the employee  stock option plans and a Stock Option  Committee for
the directors stock option plan.
     The  responsibilities  of the  Audit  Committee  include  (i)  annually  to
recommend a firm of independent  public accountants to the Board of Directors to
act as auditors of the  Company;  (ii) review the scope of the annual audit with
the auditors in advance of the audit,  (iii) review the results of the audit and
the adequacy of the Company's accounting, financial and operating controls; (iv)
review  the  Company's  accounting  and  reporting   principles,   policies  and
practices; and (v) approval of fees paid to the auditors for audit and non-audit
services. The current members of the Audit Committee are Messrs. Jay Levy, Allen
Bloom and Robert Hendrickson. The Audit Committee held one meeting during 1998.
     The  responsibilities of the Compensation  Committee include (i) review and
approval of the compensation  (including  salaries and bonuses) of the Company's
officers; (ii) overseeing the administration of the Company's 401(k) Plan; (iii)
review and  approve  general  benefits  and  compensation  strategies;  and (iv)
preparation or approval of the  Compensation  Committee  report  included in the
Company's proxy statement. The current members of the Compensation Committee are
Messrs. Jay Levy, Allen Bloom and Robert Hendrickson. The Compensation Committee
was established in December 1998 and held no meetings during 1998.
     Subject  to the  limitations  set  forth in the  plans,  the  Stock  Option
Committee  for the employee  stock option plans (i) selects the  employees to be
granted  options;  (ii) fixes the number of shares to be covered by the  options
granted;  and (iii) determines the exercise price and other terms and conditions
of each option.  The current members of the Committee are Allen Bloom and Robert
Hendrickson. There were no meetings held by this Committee during 1998.
     Subject  to the  limitations  set  forth  in the  plan,  the  Stock  Option
Committee for the directors  stock option plan interprets the plan and makes all
determinations  necessary for the plan's administration.  The current members of
the Committee are Jay Levy,  Warren Levy and Ronald Levy. There were no meetings
held by this committee during 1998.
<PAGE>
     Directors who are neither  employees nor consultants on retainer  receive a
fee of $1,000 for each Board meeting  attended.  Mr. Robert G. Ruark, Mr. Robert
F.  Hendrickson and Dr. Allen Bloom were the directors who received such fees in
1998.  Board  members  do not earn  additional  compensation  for  service  on a
committee.

     Under the 1994 Outside  Directors Stock Option Plan, each person who was an
outside  director at the time of the adoption of the Plan was granted,  and each
person who subsequently is elected as an outside director is granted, a ten-year
option to purchase  30,000 shares of Common Stock at an exercise  price equal to
the market price of the Common Stock on the date of the grant.  The options vest
in equal  increments  over the  three-year  period  following the grant.  If the
recipient's service as a director  terminates,  the option will expire three (3)
months after the date of such  termination.  Messrs.  Hendrickson and Bloom each
have received under the Plan grants of options to purchase 30,000 shares.  A new
stock option plan for directors to replace the Plan is being submitted to a vote
of  stockholders  at the  Annual  Meeting.  See  "Approval  of  Adoption  of the
Directors Stock Option Plan". 

REPORT OF THE BOARD OF DIRECTORS ON 1998 EXECUTIVE COMPENSATION

     The entire Board of Directors  was  responsible  for  determining  the 1998
compensation  of the  three  executive  officers  of the  Company.  This  Report
describes  the  policies  and  other   considerations   used  by  the  Board  in
establishing such compensation.
     The  members  of the Board are  familiar  with  various  forms and types of
remuneration  from reports of other public  corporations  and their own business
experience.
     The Board has determined that,  because the Company was still in a research
and preproduction  phase in 1998,  compensation for 1998 for executive  officers
could not be related  primarily to the  performance of the Company's stock or to
the annual profit  performance of the Company.  A primary  consideration for the
compensation of an executive  officer of the Company is his leadership effort in
the  development  of  proprietary  products and  processes,  and in planning for
future growth and  profitability.  Other significant  factors  considered by the
Board of Directors in determining executive officers' compensation were salaries
paid by other public companies in the health-care related biotechnology field to
comparable  officers,  the duties and responsibilities of the executive officers
in the past and as  projected,  their past  performance  and  commitment  to the
Company,  and incentives for future  performance  although no specific weighting
was allocated to any of these  considerations.  The executive officers were also
consulted with respect to their  compensation  and their plans for  compensation
for other  personnel in order to  coordinate  all  compensation  policies of the
Company.
     The Board of  Directors  determined  that no  bonuses  or salary  increases
should be paid to  executive  officers  in 1998,  primarily  on the basis of the
Company's  losses and the  projected  expenses  and cash flow  required  for the
further  development  of the Company's  oral  calcitonin  product as well as the
regulatory expenses for the Company's injectable form of calcitonin.
     The Board also  determined  that no stock  options be awarded to  executive
officers for 1998, at the request of such executive officers.
     The compensation for the Chief Executive  Officer for 1998 was based on the
same  policies  and  considerations  set  forth  above  for  executive  officers
generally.
                              Warren P. Levy          Robert F. Hendrickson
                              Ronald S. Levy          Robert G. Ruark
                              Jay Levy                Allen Bloom
<PAGE>
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     Executive compensation for 1998 was determined by the Board of Directors of
the Company  consisting  of Messrs.  Warren P. Levy,  Ronald S. Levy,  Jay Levy,
Robert F. Hendrickson, Robert G. Ruark, and Allen Bloom.
     Three of the six member Board of Directors,  Warren P. Levy, Ronald S. Levy
and Jay Levy, are executive  officers of the Company.  Jay Levy is the father of
Warren and Ronald Levy.
     During 1995,  Warren P. Levy,  Ronald S. Levy, Jay Levy, and another family
member  loaned a total of  $1,905,000 to the Company,  of which  $1,850,000  was
secured by secondary  liens on the Fairfield plant and equipment and the Boonton
manufacturing  equipment.  The notes bear  interest at the Merrill  Lynch Margin
Loan Rate plus .25% (8.125% at April 1, 1999).  A total of $440,000 in principal
repayments  was made during 1996. In 1997, an aggregate of $200,000 in principal
amount was converted  into 57,200 shares of Common Stock.  In 1998, an aggregate
of $225,000 in principal amount of these loans was converted into 163,635 shares
of Common Stock,  leaving an  outstanding  balance of $1,040,000 at December 31,
1998. In each case,  such  conversions  were at a price slightly higher than the
then market price of the Common Stock.  No interest has been paid to date on the
loans. As of December 31, 1998, accrued interest totalled $493,515.



EXECUTIVE COMPENSATION

     The  following  table  sets  forth,  for the  years  1998,  1997 and  1996,
compensation  paid to the Chief  Executive  Officer of the  Company  and to each
other  executive  officer  whose  compensation  in 1998 exceeded  $100,000,  for
services  rendered by such  executive  officers in all  capacities in which they
served:

<PAGE>

                           SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>
                                     Annual Compensation               Long Term Compensation               Compensation(1)
                                      -------------------               ----------------------               ---------------
                                                                               Awards             Payouts
                                                                        ----------------------    -------
                                                             Other      Restricted
Name and                                                    Annual         Stock     Options/       LTIP        
Principal Position        Year      Salary       Bonus   Compensation      Award       SARs       Payouts       
- ------------------        ----      ------       -----   ------------   ----------   --------     -------       
<S>                       <C>       <C>          <C>         <C>           <C>         <C>          <C>          <C>    
Warren P. Levy,           1998      $146,231     $-0-        $-0-          $-0-        $-0-         $-0-         $13,830
  President, Chief        1997       145,549      -0-         -0-           -0-         -0-          -0-          13,810
  Executive Officer       1996       145,454      -0-         -0-           -0-         -0-          -0-          13,806
  and Director                                                                                                
Dr. Ronald S. Levy,       1998       141,618      -0-         -0-           -0-         -0-          -0-          16,792
  Executive Vice          1997       140,895      -0-         -0-           -0-         -0-          -0-          16,756
  President and           1996       140,889      -0-         -0-           -0-         -0-          -0-          16,746
  Director                                                                                                    
</TABLE>
- ----------
(1)  Represents  premium  paid by the  Company on  executive  split-dollar  life
     insurance.

                   SHAREHOLDER RETURN PERFORMANCE PRESENTATION

     Set forth below is a line graph comparing the yearly  percentage  change in
the cumulative  total  stockholder  return on the Company's  Common Stock to the
cumulative  total  return of the NASDAQ  Market  Index and of a peer group index
determined by Standard Industrial Classification (SIC) code.


                      COMPARISON OF CUMULATIVE TOTAL RETURN
                   OF COMPANY, INDUSTRY INDEX AND BROAD MARKET

[ GRAPHIC PLOTTED TO POINTS IN CHART BELOW]
<TABLE>
<CAPTION>
                               FISCAL YEAR ENDING
COMPANY/INDEX/ MARKET         12/31/1993     12/31/1994     12/31/1995          12/31/1996     12/31/1997     12/31/1998

<S>                                <C>            <C>         <C>               <C>                <C>          <C>  
Unigene Laboratories, Inc.         100.00         95.00       52.50             81.25              105.00       47.50
Commercial Physical Research       100.00         67.12      130.29            115.90              132.20       145.12
NASDAQ Market Index                100.00        104.99      136.18            169.23              207.00       291.96    
</TABLE>
                    Assumes $100 Invested on January 1, 1994
                          Assumes Dividends Reinvested
                        Fiscal Years Ending December 31.

<PAGE>
The industry index chosen was:
SIC Code 8731 - Commercial Physical & Biological Research

The Broad Market index chosen was:
NASDAQ Market Index

The current composition of the industry index is as follows:
<TABLE>
<S>                                       <C>                                      <C>
Abiomed Inc.                              Ecogen Inc.                              Neopharm Inc
AC Nielsen Corp.                          Ecoscience Corp.                         Neose Technologies Inc.
Affymetrix Inc.                           Electronic Designs Inc.                  Neotherapeutics Inc
Agritope Inc.                             Electrosource Inc..                      Neurocrine Biosciences
Aura Systems Inc.                         Energy Biosystems Corp.                  Ophidian Pharmaceuticals
Aurora Biosciences Corp.                  Energy Conversn Devices                  Organogenesis Inc
Bioreliance Corp.                         Excel Technology Inc                     Pacific Biometrics Inc.
Cadus Pharmaceutical CP                   Gene Logic Inc.                          Parexel Internat CP.
Catalytica Inc.                           Genset ADR                               Pharmaceutical Prod. Dev.
Celgene Corp.                             Illinois Superconductor                  Pharmacopeia Inc.
Cocensys Inc.                             Incyte Pharmaceuticals                   Polymer Research of Amer.
Collaborative Clin. Res.                  Innerdyne Inc.                           Protein Polymer Tech.
Collateral Therapeutics                   Integrated Process Equip.                Quest Diagnostics Inc.
Combichem Inc.                            Irvine Sensors Corp.                     Quintiles Transnational
Commonwealth Biotech Inc.                 Kendle Internat Inc.                     Research Frontiers Inc..
Conductus Inc.                            KFX Inc.                                 Ribogene Inc..
Covance Inc.                              Kopin Corp.                              Satcon Technology Corp.
Cree Research Inc.                        Krug Internat Corp.                      Spire Corp.
Curagen Corp.                             Lifecell Corporation                     Summit Technology Inc.
CV Therapeutics Inc.                      Liposome Co. Inc..                       Superconductor Tech.
Depomed Inc.                              Megabios Corp.                           Synaptic Pharmaceutical
                                          Myriad Genetics Inc.                     Valence Technology Inc.
                                                                                   Xenova GR PLC ADS
                                                                                   XXSYS Technologies Inc.
</TABLE>

<PAGE>
                                   PROPOSAL 2
             APPROVAL OF ADOPTION OF THE DIRECTORS STOCK OPTION PLAN

     The Board of Directors is  submitting to  stockholders  for approval at the
1999 Annual Meeting a proposal to adopt a Directors  Stock Option Plan (the "New
Plan") to  replace  the 1994  Outside  Directors  Stock  Option  Plan (the "1994
Plan").
BACKGROUND
     The 1994 Plan was approved by  stockholders  at the  Company's  1994 Annual
Meeting.  The 1994 Plan  provides for a one-time  grant of an option to purchase
30,000  shares of Common Stock (i) to each outside  director who was a member on
the Board of  Directors at the time of the adoption of the 1994 Plan and (ii) to
each person who  subsequently  becomes an outside  director at the time of their
first election to the Board. However, there is no provision in the 1994 Plan for
the granting of any additional  options to outside  directors  after the initial
grant.  The Company  feels that it is in the best  interests of the Company,  as
well as its  stockholders,  to be able to issue  additional  options  to outside
directors. The Company believes that this would provide additional incentives to
current  directors,  and would also enhance the Company's ability to attract new
directors of quality and experience.

TERMS OF THE NEW PLAN

     The  following  is a summary of the  material  terms of the New Plan.  This
summary is  qualified  in its entirety by reference to the text of the New Plan,
which is included as Attachment A to this Proxy Statement.
     Eligibility.  Only  directors  who are not  employees  of the  Company  are
eligible to participate in the New Plan ("non-employee directors").
<PAGE>
     Awards. After the effective date of the New Plan (which is the day on which
stockholders' approval is obtained), each person elected to the Board who is not
an employee  will  receive,  on the date of his initial  election,  an option to
purchase 21,000 shares of Common Stock (an "Initial Option"). On May 1st of each
year,  commencing May 1, 1999, each non-employee director will receive an option
to purchase  10,000  shares of Common  Stock if he has served as a  non-employee
director  for at least six  months  prior to the May 1st  grant (an  "Additional
Option").
     Term.  Each option  granted  under the New Plan will have a ten-year  term.
Exercise  Price.  The exercise  price of each option will be equal to the market
price of the Common Stock on the date of the grant.
     Vesting.  Each Initial Option will vest in equal installments of 1/3 over a
period of three  years,  commencing  on the date of the grant.  Each  Additional
Option will vest in its entirety on the first anniversary of the grant.
     Exercise of Options.  All options will become  exercisable upon the vesting
thereof,  and shall remain  exercisable  for the  remaining  term of the option,
unless the director's service as a non-employee director terminates prior to the
expiration of the term. If the grantee's service as a director  terminates prior
to the  expiration  of the option,  the options  will remain  exercisable  for a
90-day period  following  termination  of service,  except (i) if a non-employee
director resigns due to disability,  the options will remain exercisable for 180
days  following  termination,  and (ii) if a  non-employee  director  dies while
serving as a director,  or within 90 days following  termination of service (180
days in the case of  disability),  the options will remain  exercisable  for 180
days following the person's death. After such period, the options will terminate
and cease to be exercisable.
     Administration.  The New Plan will be administered by a committee appointed
by the Board of  Directors  consisting  of  directors  who are not  eligible  to
participate in the New Plan (the "Committee").
     Number of Shares  Available  for  Issuance.  A total of  350,000  shares of
Common Stock will be reserved for issuance under the Plan.
<PAGE>
AWARDS UNDER THE NEW PLAN
     The stock option  holdings  (consisting  entirely of a grant under the 1994
Plan) of the current outside directors who are standing for re-election, as well
as the vesting schedule, are as follows:
<TABLE>
<CAPTION>
                                                                                  Vesting Schedule
                                                                                  ----------------
                                     Total Number     Exercise      Through
                                       of Shares        Price        1998         1999        2000       2001
                                        ------         ------       ------       ------     ------      ------

<S>                                     <C>             <C>                      <C>        <C>         <C>   
              Allen Bloom               30,000          $2.75           --       10,000     10,000      10,000
              Robert Hendrickson        30,000          $2.81       10,000       10,000     10,000          --
                                        ------                      ------       ------     ------      ------

              Totals                    60,000                      10,000       20,000     20,000      10,000
                                        ======                      ======       ======     ======      ======
</TABLE>
     The last sale price of the Common Stock on April 30,  1999,  as reported by
Nasdaq, was $.75 per share.
     If the  Plan  is  approved  by the  stockholders,  the  1994  Plan  will be
terminated,  except for options currently outstanding.  The current non-employee
directors will not receive an Initial Option under the New Plan.  However,  they
will each receive  Additional  Options to purchase 10,000 shares of Common Stock
effective as of May 1, 1999, and on each anniversary  thereafter.  
     The following  table  summarizes the stock option grants that would be made
under the New Plan assuming that it is approved at the 1999 Annual Meeting.  The
exercise  price of the options  will be equal to the market  price of the Common
Stock on May 1, 1999.

                                New Plan Benefits

<TABLE>
<CAPTION>
                                                      Number of Shares
              Name                              Underlying Additional Options
              ----                              -----------------------------
              <S>                                          <C>   
              Allen Bloom                                  10,000
              Robert Hendrickson                           10,000
</TABLE>

FEDERAL INCOME TAX CONSEQUENCES
     All options granted under the New Plan will be non-qualified stock options.
     In general,  a holder will not recognize  income when an option is granted.
When a holder exercises an option,  the holder generally will recognize ordinary
income equal to the excess of the fair market value (as of the exercise date) of
the shares of Common Stock purchased over the exercise  price.  The holder's tax
basis in the shares generally will be the sum of the amount that the holder pays
for the shares and the ordinary income that the holder recognizes as income as a
result of  exercising  the  option.  Accordingly,  the tax  basis of the  shares
generally  will equal the fair  market  value of the shares on the date when the
holder exercises the option.
<PAGE>
     The  Committee  may permit a holder to surrender  shares of Common Stock in
payment of the  exercise  price  under an option.  To the extent that the holder
receives  shares  that are  equal  in  number  to the  shares  that  the  holder
surrenders, the holder's tax basis in the shares that he receives will equal his
tax basis in the  surrendered  shares.  To the extent  that the holder  receives
shares in excess of the number of shares that the holder surrenders,  the holder
will  recognize  ordinary  income,  at the time of  exercise,  equal to the fair
market value of the  additional  shares reduced by any cash that the holder pays
as part of the exercise price.  The holder's tax basis in the additional  shares
will be the sum of the amount that the holder  recognizes as ordinary income and
any cash that the holder pays as part of the exercise price.
     If a holder disposes of shares  acquired by the exercise of an option,  the
holder will  recognize gain (or loss) in the year of the  disposition.  The gain
(or loss) will equal the difference  between any amount that the holder realizes
on the disposition and the holder's tax basis in the shares.
     The Company  generally  will be entitled  to a tax  deduction  in an amount
equal to the ordinary  income  recognized by a holder,  provided that the amount
qualifies as an ordinary and  necessary  business  expense.  The Company will be
entitled to claim the deduction in the same year in which the holder  recognizes
ordinary income. 

VOTE REQUIRED

     The  affirmative  vote of the holders of a majority of the shares of Common
Stock  present in person or  represented  by proxy and  entitled  to vote at the
Annual Meeting is required to approve the adoption of the New Plan. The Board of
Directors recommends a vote FOR approval of the New Plan.
<PAGE>
                                   PROPOSAL 3
             RATIFICATION OF THE APPOINTMENT OF INDEPENDENT AUDITORS

     The  Board  of  Directors  has  appointed  KPMG  LLP,   independent  public
accountants,  to serve as the Company's independent auditors for the fiscal year
commencing January 1, 1999.  Although not required by the Company's  Certificate
of Incorporation  or By-Laws,  the Board of Directors is submitting to a vote of
the  stockholders  a proposal to ratify the  appointment  of KPMG LLP.  KPMG LLP
served as the  independent  auditors for the Company for the year ended December
31, 1998. A representative of the firm will be present at the meeting to respond
to appropriate  questions and will have the opportunity to make a statement,  if
such representative desires to do so.
     Ratification of the  appointment of KPMG LLP requires the affirmative  vote
of a majority of the shares of Common Stock  present and entitled to vote at the
Annual Meeting.
     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE RATIFICATION OF KPMG LLP.
OTHER MATTERS
     The Board of Directors  of the Company  does not know of any other  matters
that are likely to be brought before the meeting. However, in the event that any
other  matters  properly  come  before the  meeting,  the  persons  named in the
enclosed form of proxy will vote all proxies  received in accordance  with their
judgment on such matters.
PROPOSALS BY STOCKHOLDERS
     Stockholder  proposals  intended to be presented at the 2000 Annual Meeting
must be received by the Company on or before  January 15,  2000,  in order to be
considered for inclusion in the Company's  proxy statement and form of proxy for
the Annual Meeting,  and must also meet the other  requirements set forth in the
rules of the Securities  and Exchange  Commission  relating to such  stockholder
proposals. If the proposal is received by the Company less than 45 days prior to
the anniversary of the mailing date of this proxy  statement,  the persons named
as proxies in the Company's proxy material for the 2000 Annual Meeting will have
the discretionary  authority to vote on the matter in accordance with their best
judgment without  disclosure in the proxy statement of such matter or of how the
proxyholders   intend  to  exercise  their   discretionary   voting   authority.
SOLICITATION OF PROXIES
     The cost of preparing,  assembling  and mailing this Proxy  Statement,  the
Notice of Meeting and the  enclosed  form of proxy will be borne by the Company.
In addition to the  solicitation of proxies by use of the mails, the Company may
utilize the  services of some of its officers  and regular  employees  (who will
receive no  compensation  therefor  in addition to their  regular  salaries)  to
solicit  proxies  personally  and by  telephone  and  telefax.  The  Company has
retained Regan & Associates,  Inc. to aid in the  solicitation  of proxies,  for
which such firm will be paid a fee of $4,500, plus reimbursable expenses.

                                              By Order of the Board of Directors

                                              RONALD S. LEVY
                                              Secretary
Fairfield, New Jersey
May 14, 1999
<PAGE>
                                                                    Attachment A

                           UNIGENE LABORATORIES, INC.
                           DIRECTORS STOCK OPTION PLAN
1.   Purpose of the Plan.

     The purpose of the  Directors  Stock  Option Plan of Unigene  Laboratories,
Inc.,  is to promote the  interests  of the Company by enhancing  the  Company's
ability to attract and retain as  non-employee  directors  persons of experience
and  ability,  and to  encourage  the  highest  level of  non-employee  director
performance  by providing  such  directors  with a  proprietary  interest in the
Company's growth and financial success.

2. Definitions.

     (a)  "Board" means the Board of Directors of the Company.
     (b)  "Code" means the Internal  Revenue Code of 1986,  as amended,  and the
          rules and regulations thereunder.
     (c)  "Committee"  means a committee  consisting of members of the Board who
          shall be appointed by the Board from time to time,  none of whom shall
          be eligible to participate in the Plan. Members of the Committee shall
          serve at the  pleasure  of the Board  and may  resign at any time upon
          written notice to the Board.
     (d) "Common  Stock"  means the $.01 par value  common stock of the Company.
     (e) "Company"  means Unigene  Laboratories,  Inc.
     (f)  "Date of Grant" means the date of grant of an Option.
     (g)  "Election  Date" means the day of the initial  election or appointment
          to the Board (whether by the stockholders of the Company or the Board)
          of a Non-employee Director.
     (h)  "Non-employee  Director"  means a member  of the  Board  who is not an
          Employee  at the time that a grant of an Option is made to such person
          under the terms of the Plan.
     (i)  "Employee" means any full-time employee of the Company, or any present
          or future parent or subsidiary of the Company.
     (j)  "Fair  Market  Value"  means  the  last  sale  price of  Common  Stock
          immediately  prior to the close of  business  on the date Fair  Market
          Value is to be determined as reported by the Nasdaq Stock Market,  or,
          if the Common Stock is not subject to last sale reporting, the average
          of the bid and asked quotations as reported by the Nasdaq Stock Market
          at the close of business on such date.  If no such last sale report or
          quotations  are available on such date,  such  determination  shall be
          made as of the next  preceding  date on which a last  sale  report  or
          quotations were available.
     (k)  "1994 Plan" means the 1994 Outside  Directors Stock Option Plan of the
          Company.
     (l)  "Option"  means a right  granted to  purchase  Common  Stock under the
          Plan.
     (m)  "Participant" means a Non-employee Director who holds an Option.
     (n)  "Plan"  means the  Directors  Stock  Option Plan of the Company as set
          forth herein and as it may be amended from time to time.
<PAGE>
3.   Shares of Common Stock Eligible for Issuance Under the Plan.

     (a)  Subject to the provisions of Section 7, the aggregate number of shares
          of Common Stock that may be issued or transferred pursuant to exercise
          of Options under the Plan shall not exceed 350,000 shares. Such shares
          may be either authorized but unissued shares or treasury shares.
     (b)  In the event that an Option  previously  granted  shall for any reason
          expire or be terminated  without being  exercised in whole or in part,
          the unpurchased  shares of Common Stock subject to the Option shall be
          restored to the total number of shares of Common Stock with respect to
          which Options may be granted under the Plan.
4.   Administration of the Plan.

     (a)  The Plan shall be administered by the Committee,  which shall have the
          sole and  complete  authority  to  interpret  the Plan and  amend  and
          rescind rules and to make all other  determinations  necessary for the
          Plan's administration.
     (b)  All  action  taken  by  the  Committee  in  the   administration   and
          interpretation  of  the  Plan  shall  be  final  and  binding  on  all
          concerned.
     (c)  The Committee  may  designate  officers or employees of the Company to
          assist the Committee in the  administration of the Plan and to execute
          documents on behalf of the  Committee,  and the Committee may delegate
          to such  officers and  employees  such other  ministerial  and limited
          discretion duties as it sees fit.
    
                                     
<PAGE>
 5. Eligibility and Awards. 

     (a)  Only directors of the Company who are Non-employee  Directors shall be
          eligible to participate in the Plan.

     (b)  Options shall be granted under the Plan as follows:

          (i)  on the Election Date of a Non-employee Director that occurs on or
               after the effective date of the Plan, such Non-employee  Director
               shall be granted an Option to  purchase  21,000  shares of Common
               Stock (an "Initial Option");

          (ii) commencing  on May  1,  1999,  and on  each  succeeding  May  1st
               thereafter, each Non-employee Director shall be granted an Option
               to purchase  10,000  shares of Common Stock if such  Non-employee
               Director has served as a  Non-employee  Director for at least six
               months prior to each May 1st (an "Additional Option").

     (c)  Each Option shall be evidenced by a written  instrument  that includes
          such terms and conditions,  consistent with the Plan, as the Committee
          may determine (a "Stock Option Agreement").

 6. Terms and  Conditions  of Options.

     (a)  The purchase price of Common Stock under each Option shall be equal to
          the Fair Market Value of the Common Stock on the Date of Grant.

     (b)  Each  Option  shall  expire  on the tenth  anniversary  of its Date of
          Grant, unless it expires sooner pursuant to the provisions of the Plan
          or the Stock Option Agreement.

     (c)  Each Initial  Option shall  become  exercisable  with respect to 7,000
          shares on each of the  first,  second and third  anniversaries  of its
          Date of Grant.  Each Additional  Option shall become  exercisable with
          respect to all 10,000 shares of Common Stock on the first  anniversary
          of its Date of Grant.  In no event,  however,  shall any Option become
          exercisable  with  respect  to any  shares of Common  Stock  after the
          Participant ceases to be a director of the Company for any reason.

     (d)  Any Option that has not  theretofore  expired shall  terminate 90 days
          following the termination of the  Participant's  service as a director
          of the  Company  for any  reason,  and no shares  of Common  Stock may
          thereafter be purchased pursuant to such Option, except that:

          (i)  Upon  the  resignation  of a  Participant  as a  director  due to
               disability,  the  Participant  may, within a 180-day period after
               the  date of such  termination,  purchase  all or any part of the
               shares of Common  Stock that such  Participant  was  entitled  to
               purchase under such Option on the date of such termination.

          (ii) Upon the death of a  Participant  while  serving as a director or
               within the 90-day  period  referred to above,  the  Participant's
               estate or the person to whom such Participant's  rights under the
               Option  are  transferred  by will  or the  laws  of  descent  and
               distribution  may, within a 180-day period after the date of such
               Participant's  death,  purchase  all or any part of the shares of
               Common Stock that such Participant was entitled to purchase under
               such Option on the date of death.

     (e)  Upon the exercise of an Option, the purchase price shall be payable in
          full in cash;  provided,  however,  that the  Committee  may determine
          acceptable  methods for tendering shares of Common Stock in payment of
          the  exercise  price,  and  may  impose  such  other  limitations  and
          prohibitions on the tendering of such shares as it deems  appropriate.
          Any shares so tendered to the Company in payment or partial payment of
          the  purchase  price shall be valued at their Fair Market Value on the
          exercise date.

     (f)  No Option shall be exercisable in whole or in part and no certificates
          representing  shares of Common  Stock  subject to the Option  shall be
          delivered,

          (i)  If  any  requisite   approval  or  consent  of  any  governmental
               authority having  jurisdiction over the exercise of Options shall
               not have  been  secured  or if the  issuance  of shares of Common
               Stock subject to the Option would  violate any federal,  state or
               local law, regulation or order;

          (ii) At any time that the Common  Stock of the  Company is listed on a
               stock  exchange  or the  Nasdaq  Stock  Market,  if the shares of
               Common   Stock   subject  to  the  Option  shall  not  have  been
               effectively  listed on such  exchange or the Nasdaq Stock Market,
               unless the Company is advised by its counsel that such listing is
               not required; or

          (iii)At any time that the Company shall  determine that any applicable
               withholding tax or other  withholding  obligations  have not been
               satisfied.

                                 
<PAGE>
7.   Adjustment    Provisions. 
     If any  subdivision  or  combination of shares of Common Stock or any stock
dividend,  capital reorganization or recapitalization occurs after the effective
date of the Plan, the Committee shall make such proportionate adjustments as are
appropriate  in the number of shares of Common  Stock  that may be issued  under
Section 3 and in the  purchase  price of, and the  number of shares  underlying,
outstanding  Options in order to prevent  the  dilution  or  enlargement  of the
rights of each Participant.

8.   Effect of Merger or Other Reorganization. 

     If the  Company  dissolves,  sells  substantially  all of  its  assets,  is
acquired in a stock-for-stock or securities exchange, or is a party to a merger,
consolidation  or  other  reorganization  in  which  it  is  not  the  surviving
corporation,  then  each  Option  shall  be  exercisable  in full  for a  period
commencing  upon the date the action of the  stockholders  (or of the Board,  if
stockholder  action is not  required)  is taken to approve the  transaction  and
ending on the date of consummation of such transaction,  and upon the expiration
of  that  period  all  Options  and  all  rights  with  respect   thereto  shall
automatically  terminate;  except  that,  if  following  such  approval  no such
transaction is  consummated,  all outstanding  Options not exercised  during the
period will be restored to their original vesting schedule.

9.   General Provisions.

     (a)  Nothing in the Plan or in any instrument executed pursuant to the Plan
          shall confer upon any  Participant any right to continue to serve as a
          director of the Company.

     (b)  No shares of Common Stock shall be issued  pursuant to the exercise of
          an Option  unless and until all  requirements  imposed by federal  and
          state  securities  and other laws,  rules and  regulations  and by any
          regulatory agencies having jurisdiction, and by any stock exchanges or
          the Nasdaq  Stock  Market  upon which the Common  Stock may be listed,
          have been fully satisfied. As a condition precedent to the issuance of
          shares pursuant to the exercise of an Option,  the Company may require
          the   Participant  to  take  any   reasonable   action  to  meet  such
          requirements.

     (c)  No Participant shall be entitled to the rights and privileges of stock
          ownership  relating to any shares of Common Stock underlying an Option
          granted  hereunder  until such Option is exercised  and the shares are
          issued.

     (d)  Each Option is personal to the  grantee,  is not  transferable  by the
          Participant  other  than  by  will  or by  the  laws  of  descent  and
          distribution or a "qualified  domestic  relations order" as defined by
          the Code, and is exercisable,  during the Participant's lifetime, only
          by the  Participant  or his legal  representative.  


10.  Amendment and Termination.
     The Board shall have the power, in its sole discretion,  to amend,  suspend
or terminate the Plan at any time;  provided that no such amendment,  suspension
or termination of the Plan shall, without the consent of the Participant, alter,
terminate,  impair or adversely  affect any right or obligation under any Option
previously granted under the Plan.

11.  Effective  Date and Duration of Plan.  
     This  Plan  shall  become  effective  on the date  that it is  approved  by
stockholders  of the Company at the  Company's  1999 Annual  Meeting.  No Option
shall be granted under the Plan after the tenth  anniversary  of such  effective
date or, if earlier, the termination of the Plan pursuant to Section 10.

12.  Termination of 1994 Plan. 
     On the effective  date of the Plan, the 1994 Plan shall  terminate,  except
for currently issued and outstanding  options that shall remain  outstanding and
subject to the terms of the 1994 Plan.

                               
<PAGE>
                                REVOCABLE PROXY
                           UNIGENE LABORATORIES, INC.

[X]  PLEASE MARK VOTES AS IN THIS EXAMPLE


          PROXY SOLICITED BY THE BOARD OF DIRECTORS FOR ANNUAL MEETING
                                  JUNE 23, 1999

     The undersigned  stockholder of Unigene Laboratories,  Inc. hereby appoints
Warren  P.  Levy,  Ronald  S.  Levy  and Jay  Levy,  and  each of  them,  as the
undersigned's  proxies (with the power of substitution),  to vote all the shares
of Common Stock of Unigene  Laboratories,  Inc. which the  undersigned  would be
entitled to vote at the Annual Meeting of Stockholders of Unigene  Laboratories,
Inc. to be held on June 23, 1999 at 11:00 A.M.,  Eastern  Daylight time, and any
adjournments thereof, on the following matters:


1. Election of directors                                                 For All
                                    [   ] For   [   ] Withhold    [   ]  Except
   Jay Levy, Ronald S. Levy,               
   Warren P. Levy, Robert F. Hendrickson
   and Allen Bloom.

INSTRUCTION:To  withhold authority to vote for any individual nominee, mark "For
All Except"and write that nominee's name in the space provided below.


- --------------------------------------------------------------------------------

2.   Approval of the adoption of the Company's Directors Stock Option Plan.

               [   ] For      [   ] Against      [   ] Abstain

3.   Ratification of the appointment of KPMG LLP as independent  auditors of the
     Company.

               [   ] For      [   ] Against      [   ] Abstain

4.   In their  discretion  in the  transaction  of any other  business  that may
     properly come before such meeting.

The undersigned hereby revokes any proxy heretofore given.
<PAGE>
     Please  sign  exactly  as your  name  appears  on this  card.  If  stock is
registered  in the names of two or more  joint  owners or  trustees,  each joint
owner  or  trustee  should  sign  this  proxy.  When  signing  as  an  executor,
administrator, trustee, guardian, agent or attorney, please give your full title
as such.
                         Please be sure to sign and date
                          this Proxy in the box below.

                   ________________________________________
                                    Date
 
                   _________________________________________
                             Stockholder sign above
 
                   _________________________________________
                         Co-holder (if any) sign above


    Detach above card, sign, date and mail in postage paid envelope provided.

                           UNIGENE LABORATORIES, INC.
- --------------------------------------------------------------------------------
  This proxy will be voted in accordance with instructions  specified above, but
in the absence of any instructions  will be voted "FOR" Items 1, 2 and 3. If any
other  business is presented at the meeting,  the proxies are authorized to vote
thereon in their discretion.

  The Board of Directors recommends a vote FOR Items 1, 2 and 3 noted above.

                               PLEASE ACT PROMPTLY
                     SIGN, DATE & MAIL YOUR PROXY CARD TODAY


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