UNIGENE LABORATORIES INC
10-Q, 1999-11-19
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                    FORM 10-Q

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

(Mark One)

[X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES  EXCHANGE
ACT OF 1934

For the quarterly period ended September 30, 1999

Commission file number 0-16005

Unigene Laboratories, Inc.
- --------------------------
(Exact name of registrant as specified in its charter)

            Delaware                             22-2328609
- -------------------------------              ----------------
(State or other jurisdiction of              (I.R.S. Employer
 incorporation or organization)              Identification No.)


110 Little Falls Road, Fairfield, New Jersey            07004
- ---------------------------------------------------------------
(Address of principal executive offices)             (Zip Code)

Registrant's telephone number, including area code: (973) 882-0860
- ------------------------------------------------------------------

(Former  name,  former  address and former  fiscal year,  if changed  since last
report.)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes X No__.

APPLICABLE ONLY TO CORPORATE ISSUERS

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date:

Common Stock, $.01 Par Value - 41,174,329 shares as of November 1, 1999
<PAGE>
                                      INDEX

                           UNIGENE LABORATORIES, INC.

PART I.  FINANCIAL INFORMATION                                          PAGE

Item 1. Financial Statements (Unaudited)

Condensed balance sheets-
    September 30, 1999 and December 31, 1998                             3

Condensed statements of operations-
    Three months and nine months ended September 30, 1999 and 1998       4

Condensed statements of cash flows-
    Nine months ended September 30, 1999 and 1998                        5

Notes to condensed financial statements-
    September 30, 1999                                                   6

Item 2. Management's Discussion and Analysis of Financial
    Condition and Results of Operations                                  9

Item 3. Quantitative and Qualitative Disclosures About
    Market Risk                                                         13

PART II. OTHER INFORMATION

Item 2.       Changes in Securities and Use of Proceeds                 14

Item 6.       Exhibits and Reports on Form 8-K                          15

SIGNATURES                                                              16
<PAGE>
PART I.  FINANCIAL INFORMATION
Item 1. Financial Statements

                           UNIGENE LABORATORIES, INC.
                            CONDENSED BALANCE SHEETS
<TABLE>
<CAPTION>
                                                                              September 30       December 31
                                                                                  1999              1998
                                                                              ------------      ------------
ASSETS                                                                        (Unaudited)
<S>                                                                           <C>               <C>
Current assets:
    Cash and cash equivalents                                                 $    668,379      $    402,664
    Contract receivable                                                          2,000,000              --
    Prepaid expenses                                                                68,633           317,823
    Other current assets                                                           702,028           887,904
                                                                              ------------      ------------
         Total current assets                                                    3,439,040         1,608,391

Contract receivable                                                              2,000,000              --
Property, plant and equipment-net
    of accumulated depreciation and amortization                                 7,030,523         8,085,250
Patents and other intangibles, net                                               1,228,076         1,206,018
Other assets                                                                       512,957           664,434
                                                                              ------------      ------------
                                                                              $ 14,210,596      $ 11,564,093
                                                                              ============      ============
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
    Accounts payable                                                          $    924,605      $    982,752
    Accrued expenses                                                             1,645,016         1,329,199
    Notes payable - stockholders                                                 1,140,000         1,040,000
    Current portion-stockholder notes                                              758,988              --
    Current portion-capital lease obligations                                       61,464            61,464
                                                                              ------------      ------------
  Total current liabilities                                                      4,530,073         3,413,415

Stockholder notes, excluding current portion                                     1,111,012              --
5% convertible debentures                                                        2,800,000         3,802,807
Capital lease obligations, excluding current portion                                75,994           127,783

   Stockholders' equity:
    Common stock-par value $.01 per share;
       authorized 60,000,000 shares, issued
       41,181,619 shares in 1999 and 39,384,822 in 1998                            411,816           393,848
    Additional paid-in capital                                                  66,462,635        65,158,403
    Accumulated deficit                                                        (61,179,903)      (61,331,132)
    Less: Treasury stock, at cost, 7,290 shares                                     (1,031)           (1,031)
                                                                              ------------      ------------
         Total stockholders' equity                                              5,693,517         4,220,088
                                                                              ------------      ------------
                                                                              $ 14,210,596       $11,564,093
                                                                              ============      ============
</TABLE>
See notes to condensed financial statements.
<PAGE>
                           UNIGENE LABORATORIES, INC.
                       CONDENSED STATEMENTS OF OPERATIONS
                                   (Unaudited)
<TABLE>
<CAPTION>
                                                Three Months Ended                  Nine Months Ended
                                                   September 30                        September 30
                                              1999              1998              1999              1998
                                          ------------      ------------      ------------      ------------
<S>                                       <C>               <C>               <C>               <C>
Licensing and other revenue               $  7,000,733      $  3,008,795      $  9,527,575      $  5,020,652
Operating expenses:

    Research and development                 2,651,584         2,384,413         7,261,543         6,791,085
    General and administrative                 561,811           494,585         1,653,944         1,552,113
                                          ------------      ------------      ------------      ------------

                                             3,213,395         2,878,998         8,915,487         8,343,198
                                          ------------      ------------      ------------      ------------

Operating income (loss)                      3,787,338           129,797           612,088        (3,322,546)
                                          ------------      ------------      ------------      ------------
Other income (expense):
   Interest/other income                        13,308            37,290            28,850            81,384
   Interest expense                           (108,052)         (103,692)         (489,709)         (211,970)
                                          ------------      ------------      ------------      ------------
                                               (94,744)          (66,402)         (460,859)         (130,586)
                                          ------------      ------------      ------------      ------------
Income (loss) before
   extraordinary item                        3,692,594            63,395           151,229        (3,453,132)

Extraordinary item-loss
   on extinguishment of debt (Note D)             --            (143,810)              --           (143,810)
                                          ------------      ------------      ------------      ------------

Net income (loss)                         $  3,692,594      $    (80,415)     $    151,229      $ (3,596,942)
                                          ============      ============      ============      ============
Earnings per share (Note E):
    Basic:
     Income (loss) before
       extraordinary item                 $        .09      $       --        $       --        $       (.09)
     Extraordinary item                           --                --                --                --
                                          ------------      ------------      ------------      ------------
     Net income (loss)                    $        .09      $       --        $       --        $       (.09)
                                          ============      ============      ============      ============
    Diluted:
     Income (loss) before
       extraordinary item                 $        .09      $       --        $       --        $       (.09)
     Extraordinary item                           --                --                --                --
                                          ------------      ------------      ------------      ------------
     Net income (loss)                    $        .09      $       --        $       --        $       (.09)
                                          ============      ============      ============      ============
Weighted average number of shares
 outstanding:     Basic                     41,169,120        38,647,682        40,284,824        38,562,591
                                          ============      ============      ============      ============
                  Diluted                   43,159,961        38,647,682        40,284,824        38,562,591
                                          ============      ============      ============      ============
</TABLE>
See notes to condensed financial statements.
<PAGE>
                           UNIGENE LABORATORIES, INC.
                       CONDENSED STATEMENTS OF CASH FLOWS
                                   (Unaudited)
<TABLE>
<CAPTION>
                                                                 Nine Months Ended
                                                                    September 30
                                                            ----------------------------
                                                               1999             1998
                                                            -----------      -----------

<S>                                                         <C>              <C>
Net cash used for operating activities                      $(1,553,470)     $(2,085,805)
                                                            -----------      -----------
Investing activities:

    Purchase of equipment and furniture                         (75,263)        (261,927)
    Increase in patents and other assets                        (19,753)        (122,474)
    Construction of leasehold and building improvements          (4,010)          (5,284)
                                                            -----------      -----------
                                                                (99,026)        (389,685)
                                                            -----------      -----------
Financing activities:

    Issuance of stockholder notes                             1,970,000             --
    Issuance of 5% Debenture, net of related expenses              --          3,751,919
    Exercise of stock options and warrants                         --             47,969
    Repayment of capital lease obligations                      (51,789)            --
    Redemption of convertible debentures                           --           (107,171)
                                                            -----------      -----------
                                                              1,918,211        3,692,717
                                                            -----------      -----------
Net increase in cash and cash equivalents                       265,715        1,217,227

Cash and cash equivalents at beginning of year                  402,664        2,126,327
                                                            -----------      -----------
Cash and cash equivalents at end of period                  $   668,379      $ 3,343,554
                                                            ===========      ===========
SUPPLEMENTAL CASH FLOW INFORMATION:

Non-cash investing and financing activities:

Conversion of convertible debentures and
   accrued interest into Common Stock                       $ 1,390,959      $   204,375
                                                            ===========      ===========
Conversion of notes payable-stockholders
   into Common Stock                                        $      --        $   225,000
                                                            ===========      ===========
Cash paid for interest                                      $    17,448      $    43,455
                                                            ===========      ===========
</TABLE>
See notes to condensed financial statements
<PAGE>
                           UNIGENE LABORATORIES, INC.
                     NOTES TO CONDENSED FINANCIAL STATEMENTS
                               SEPTEMBER 30, 1999

NOTE A - BASIS OF PRESENTATION

The accompanying  unaudited condensed financial statements have been prepared in
accordance with generally accepted  accounting  principles for interim financial
information and with the  instructions to Form 10-Q and Article 10 of Regulation
S-X.  Accordingly,  they do not include  all of the  information  and  footnotes
required by generally  accepted  accounting  principles  for complete  financial
statements.  In the opinion of management,  all adjustments considered necessary
for a fair presentation have been included. Operating results for the nine-month
period ended  September 30, 1999 are not  necessarily  indicative of the results
that  may be  expected  for the  year  ended  December  31,  1999.  For  further
information,  please refer to the Company's  financial  statements and footnotes
thereto  included in the Company's annual report on Form 10-K for the year ended
December 31, 1998.

NOTE B - CONVERTIBLE DEBENTURES

During  January  1999,   $200,000  of  principal  amount  of  the  Company's  5%
Convertible  Debentures,  due December 31, 2001, were converted into (a) 164,102
shares of Common Stock and (b) warrants,  expiring January 29, 2004, to purchase
6,564  shares of  Common  Stock at an  exercise  price of $1.52  per  share.  In
addition,  the  Company  issued  79,384  shares of Common  Stock as  payment  of
interest on the 5% Convertible Debentures in lieu of a semi-annual cash interest
payment in the amount of $101,000.

During  the  second  quarter  of 1999,  $1,000,000  of  principal  amount of the
Company's 5% Convertible Debentures,  due December 31, 2001, were converted into
(a)  1,457,458  shares of Common Stock and (b) warrants,  expiring  April - June
2004,  to purchase an  aggregate  of 58,298  shares of Common  Stock at exercise
prices ranging from $.78 to $1.15 per share.

During July 1999, the Company issued 95,853 shares of Common Stock as payment of
interest on the 5% Convertible Debentures in lieu of a semi-annual cash interest
payment in the amount of $90,000.

NOTE C - NOTES PAYABLE - STOCKHOLDERS

During the second quarter of 1999 (a) Jay Levy, the chairman of the board and an
officer of the Company,  loaned the Company $1,500,000 evidenced by demand notes
bearing interest at 6% per year, and (b) Warren Levy and Ronald Levy,  directors
and officers of the  Company,  loaned the Company  $100,000  evidenced by demand
notes  bearing  interest at the Merrill Lynch Margin Loan Rate plus .25% (8.625%
at September 30, 1999) (the "Floating  Rate"). In July 1999, Jay Levy loaned the
Company an additional $370,000 evidenced by term notes maturing January 2002 and
bearing  interest at 6% per year, and the $1,500,000 of demand notes  evidencing
loans made by Jay Levy in the second  quarter were  converted into 6% term notes
maturing  January 2002. The Company has granted Jay Levy a security  interest in
all of its equipment  and a mortgage on its real  property to secure  payment of
the term notes  which are senior to all notes  payable to Warren Levy and Ronald
Levy.  The Company is required  to make  installment  payments on the term notes
commencing in October 1999 and ending in January 2002 in an aggregate  amount of
$72,426  per month.  Jay Levy has agreed to postpone  the  October and  November
installment payments.
<PAGE>
NOTE D - EXTRAORDINARY ITEM

During  September  1998,  $178,515  of  principal  amount of the  Company's  10%
Convertible  Debentures due March 4, 1999, plus $44,060 of accrued interest, was
converted into 214,131 shares of Common Stock.  Due to restrictions on the total
number of shares which could be issued upon  conversion of the  Debentures,  the
Company  redeemed  an  additional  $271,485  of  principal,  and  in  connection
therewith  paid to the holder  $68,899  of  accrued  interest  and  $143,810  in
redemption  premiums,  for an  aggregate  payment of  $484,194.  The  premium of
$143,810 was recorded as an extraordinary loss in September 1998.

NOTE E - EARNINGS PER SHARE

Basic  earnings  per share is computed by dividing  the net income  available to
common  shareholders  by the weighted  average  number of shares of common stock
outstanding.  For  purposes  of  calculating  diluted  earnings  per share,  the
denominator  includes both the weighted average number of shares of common stock
outstanding and the number of dilutive common stock equivalents.

The Company's 5% Convertible Debentures were dilutive for the three-month period
ended September 30, 1999, but anti-dilutive for all other periods. Stock options
to purchase  1,746,490 shares of Common Stock and warrants to purchase 3,983,768
shares of Common Stock were not included in computing diluted earnings per share
because their effects are anti-dilutive.

The following table sets forth the  computation  for basic and diluted  earnings
per share (EPS) for the three months ended September 30, 1999:

<TABLE>
<CAPTION>
<S>                                              <C>
Numerator for basic EPS - net income             $ 3,692,594
Interest expense - 5% Convertible Debentures          35,287
                                                 -----------
Numerator for diluted EPS                        $ 3,727,881
                                                 -----------
Denominator for basic EPS - weighted
  average shares outstanding                      41,169,120

Effect of conversion of 5% Convertible
  Debentures into maximum number of shares         1,990,841
                                                 -----------

Denominator for diluted EPS                       43,159,961
                                                 ===========
</TABLE>
NOTE F - LIQUIDITY

The Company has incurred annual  operating  losses since its inception and, as a
result,  at  September  30,  1999 had an  accumulated  deficit of  approximately
$61,180,000  and a working  capital  deficit of  approximately  $1,091,000.  The
independent  auditors'  report covering the Company's 1998 financial  statements
includes  an   explanatory   paragraph  that  states  the  above  factors  raise
substantial  doubt about the Company's  ability to continue as a going  concern.
However,  the financial  statements  have been prepared on a going concern basis
and as such do not include any adjustments that might result from the outcome of
this  uncertainty.  In October  1999,  the Company was  delisted by Nasdaq.  The
delisting  of the  Company's  Common  Stock  may have an  adverse  effect on the
Company's ability to raise capital.
<PAGE>
In August 1999,  the Company and  Warner-Lambert  successfully  concluded  their
second pilot human study for their oral calcitonin  formulation,  resulting in a
payment to the  Company of $2.5  million.  In  September  1999,  the Company and
Warner-Lambert  identified an oral  calcitonin  formulation  to be used in their
upcoming Phase I clinical study entitling the Company to a milestone, payable in
installments,  totaling  $4.5  million.  The first  installment  of $500,000 was
received in September 1999, with payment of an additional  $500,000 due every 90
days  thereafter,  with the unpaid  balance  payable upon the  initiation of the
Phase I study, which the Company expects to occur in the first half of 2000. Due
to the  completion of this milestone in September  1999, the Company  recognized
$4.5  million as revenue in the third  quarter;  $2 million  was  recorded  as a
current  contract  receivable  and an  additional  $2 million was  recorded as a
non-current contract receivable.

With the receipt of almost $2 million in stockholder loans during the second and
third  quarters of 1999,  in addition to an  aggregate of $3 million in payments
from  Warner-Lambert in the third quarter,  management believes that the Company
will have  sufficient  financial  resources  to sustain  its  operations  at the
current level into the fourth  quarter of 1999.  The Company  expects to receive
$500,000 from  Warner-Lambert  in December 1999, and $3.5 million in one or more
payments in the first half of 2000 from the  milestone  completed  in  September
1999.  The  Company  also  expects to achieve  additional  milestones  under the
Warner-Lambert  agreement  during 2000,  which will result in further  payments.
However,  there can be no  assurance  as to when or if the Company  will achieve
such milestones.  The Company is currently pursuing licensing agreements for its
nasal  and  injectable  calcitonin  products.  These  agreements  could  provide
short-term  funds  to the  Company  in  upfront  payments  as well as  milestone
payments.  The  Company  has  executed  an  agreement  for the sale of state tax
benefits,  to  yield  approximately  $4  million,  under a New  Jersey  Economic
Development Authority program, which allows certain New Jersey taxpayers to sell
their  state tax  benefits  to  third-parties.  However,  the  proceeds  will be
received  over the next few years and the size and timing of such  proceeds  are
subject to the  continued  funding of the  program by the State of New Jersey as
well as limitations based on the level of participation by other companies.  The
Company's  application  for the sale was  approved  by the New  Jersey  Economic
Development  Authority  in October  1999 and the  Company  expects to receive at
least $1  million  in the  first  year's  allocation.  However,  there can be no
assurance  that any of these  transactions  will be completed  or, if completed,
that the terms and timing of such transactions would provide sufficient funds to
sustain operations at the current level.

While the Company  believes that the  transactions  it currently is pursuing and
the milestone  payments  under the  Warner-Lambert  agreement  would satisfy the
Company's  liquidity  requirements  in the near term,  satisfying  the Company's
long-term liquidity  requirements will require the successful  commercialization
of its nasal or oral calcitonin product. In addition,  the  commercialization of
its  calcitonin  products will require the Company to incur  additional  capital
expenditures,   including  expenditures  to  expand  or  upgrade  the  Company's
manufacturing   operations  to  satisfy   certain  of  its   calcitonin   supply
obligations.  However,  neither the cost nor timing of such capital expenditures
is determinable at this time.
<PAGE>
NOTE G - DIRECTORS STOCK OPTION PLAN

At the Company's June 23, 1999 Annual  Meeting,  the  stockholders  approved the
adoption of a new  Directors  Stock  Option Plan (the "New Plan") to replace the
1994 Outside Directors Stock Option Plan (the "1994 Plan").  Under the New Plan,
each person elected to the Board after June 23, 1999 who is not an employee will
receive,  on the date of his  initial  election,  an option to  purchase  21,000
shares of Common Stock. In addition,  on May 1st of each year, commencing May 1,
1999,  each  non-employee  director  will  receive an option to purchase  10,000
shares of Common Stock if he or she has served as a non-employee director for at
least six months prior to the May 1st grant.  Each option  granted under the New
Plan will have a ten-year  term and the  exercise  price of each  option will be
equal to the fair value of the Company's  Common Stock on the date of the grant.
A total of 350,000  shares of Common Stock are  reserved for issuance  under the
New Plan.

Item 2. Management's  Discussion and Analysis of Financial Condition and Results
of Operations

RESULTS OF OPERATIONS

Revenue  increased 133% from $3 million to $7 million and 90% from $5 million to
$9.5  million for the three  months and nine months  ended  September  30, 1999,
respectively,  as compared to the same periods in 1998.  Revenue for all periods
consisted  primarily of milestone revenue from  Warner-Lambert  Company,  as the
result of the achievement of benchmarks in the development of an oral calcitonin
product for treating osteoporosis.

Research and  development,  the Company's  largest  expense,  increased 11% from
$2,384,000  to  $2,652,000  for the three months ended  September  30, 1999,  as
compared to the same period in 1998. Research and development expenses increased
7% from  $6,791,000 to $7,262,000 for the nine months ended  September 30, 1999,
as  compared  to the same  period in 1998.  The 1999  increases  were  primarily
attributable to consulting and testing expenses related to the Company's Type II
variation for its injectable calcitonin product, development expenses related to
the Company's  nasal  calcitonin  product,  and  consulting  fees related to the
Company's collaboration with Warner-Lambert.

General and administrative  expenses increased 14% from $495,000 to $562,000 and
7% from  $1,552,000  to  $1,654,000  for the three  months and nine months ended
September 30, 1999,  respectively,  as compared to the same periods in 1998. The
increases were primarily due to increased personnel costs and professional fees,
partially offset by reductions in public relations and travel expenses.

Interest  income  decreased  $24,000 and  $53,000 for the three  months and nine
months ended September 30, 1999,  respectively,  as compared to the same periods
in 1998, due to reduced funds available for investment in 1999.

Interest  expense  increased  $4,000 and  $278,000 for the three months and nine
months ended September 30, 1999,  respectively,  as compared to the same periods
in 1998. The nine month increase for 1999 was due primarily to the  amortization
of the value of the beneficial  conversion  feature and related  warrants of the
Company's 5% Convertible Debentures in the amount of $197,000 for the first nine
months of 1999.
<PAGE>
As a result of increased  revenue from  Warner-Lambert  milestones  during 1999,
partially  offset by increased  operating  expenses and  interest  expense,  net
income  improved by $3.7 million ($.09 per share) for both the  three-month  and
nine-month  periods  ended  September  30,  1999.  The Company had net income of
$3,693,000  for the three months ended  September  30, 1999 as compared to a net
loss of $80,000 for the comparable period in 1998. The Company had net income of
$151,000 for the nine months ended  September 30, 1999 as compared to a net loss
of $3,597,000 for the comparable period in 1998.

As of  December  31,  1998,  the Company had  available  for federal  income tax
reporting purposes net operating loss carryforwards in the approximate amount of
$58,400,000,  expiring  from 1999 through  2018,  which are  available to reduce
future earnings that would otherwise be subject to federal income taxes. For the
nine months ending September 30, 1999, the Company had a profit of approximately
$151,000.  In addition,  the Company has investment tax credits and research and
development  credits in the  amounts of $19,000  and  $2,178,000,  respectively,
which are available to reduce the amount of future federal  income taxes.  These
credits  expire from 1999 through 2018. For 1999, the Company does not expect to
have income before  income taxes in excess of its  available net operating  loss
and tax credit carryforwards.

The Company follows Statement of Financial  Accounting Standards (SFAS) No. 109,
"Accounting  for Income  Taxes".  Given the Company's  past history of incurring
operating losses,  any deferred tax assets that are recognizable  under SFAS 109
have been fully reserved. As of January 1, 1999, under SFAS 109, the Company had
deferred  tax  assets  of  approximately  $25,500,000,  subject  to a  valuation
allowance of $25,500,000.  The deferred tax assets are primarily a result of the
Company's net operating  losses and tax credits  generated.  For the  nine-month
period ended September 30, 1999, the Company's deferred tax assets and valuation
allowances each decreased by approximately $60,000.

LIQUIDITY AND CAPITAL RESOURCES

The  Company  currently  has no  material  commitments  outstanding  for capital
expenditures  relating  to the  Boonton,  New Jersey  production  facility,  the
Company's facility in Fairfield, New Jersey, or to its other activities.

The Company,  at September 30, 1999, had cash and cash  equivalents of $668,000,
an increase of $266,000 from December 31, 1998.

The Company has incurred annual  operating  losses since its inception and, as a
result,  at  September  30,  1999 had an  accumulated  deficit of  approximately
$61,180,000  and a working  capital  deficit of  approximately  $1,091,000.  The
independent  auditors'  report covering the Company's 1998 financial  statements
includes  an   explanatory   paragraph  that  states  the  above  factors  raise
substantial  doubt about the Company's  ability to continue as a going  concern.
However,  the financial  statements  have been prepared on a going concern basis
and as such do not include any adjustments that might result from the outcome of
this  uncertainty.  In October  1999,  the Company was  delisted by Nasdaq.  The
delisting  of the  Company's  Common  Stock  may have an  adverse  effect on the
Company's ability to raise capital.

The  Company's  future  ability to  generate  cash from  operations  will depend
primarily  upon signing  research or  licensing  agreements,  achieving  defined
benchmarks in such agreements,  receiving  regulatory  approval for its licensed
products, and the commercial sale of these products.
<PAGE>
In July 1997,  the Company  entered into an agreement  under which it granted to
the Parke-Davis  division of  Warner-Lambert  Company a worldwide license to use
the Company's  oral  calcitonin  technology.  Through  September  30, 1999,  the
Company had received an aggregate of $16.5  million from  Warner-Lambert  in the
form of an equity investment,  a licensing fee and milestone payments. Under the
terms of the  license  agreement,  the  Company is  eligible to receive up to an
additional  $38  million  in  milestone   payments  during  the  course  of  the
development  program.  Early-stage  milestones primarily relate to the product's
performance  characteristics,  while the  latter-stage  milestones are primarily
related to regulatory  activities and approvals.  If the product is successfully
commercialized, the Company also would receive revenue from royalties on product
sales by Warner-Lambert  and its affiliates and from the sale of raw material to
Warner-Lambert.  The  Company has  retained  the right to license the use of its
technologies for injectable and nasal  formulations of calcitonin on a worldwide
basis. The Company is actively seeking other licensing and/or supply  agreements
with  pharmaceutical  companies for  injectable  and nasal forms of  calcitonin.
However, there is no assurance that any additional revenue-generating agreements
will be signed.

The Company's cash requirements are approximately $10-11 million per year due to
the  operations of its research and peptide  manufacturing  facilities  and with
three  calcitonin  products in various stages of development.  In addition,  the
Company has principal and interest obligations over the next several years under
its  outstanding  notes payable to stockholders  and 5% Convertible  Debentures.
However,  because of the conversion features of the 5% Convertible Debentures, a
substantial  portion of this debt is expected to be converted into Common Stock,
thereby  decreasing  the amount of cash  required for  principal  payments.  The
Company may elect to pay interest on these  debentures  in Common  Stock,  which
would  decrease the amount of cash  required for interest  payments.  Due to the
delisting  of its Common  Stock  from the Nasdaq  National  Market  System,  the
Company  is  required  to make  payments  to the  holder  of the 5%  Convertible
Debentures, in an amount equal to 2% per month of the aggregate principal amount
of these  debentures  for any month or  portion  thereof.  In  addition,  if the
delisting  period lasts for 4 months,  then, at the option of the investor,  the
Company shall redeem these  debentures on a redemption  date  designated by such
investor at a redemption price equal to 120% of the outstanding principal amount
of these debentures.

During the second quarter of 1999 (a) Jay Levy, the chairman of the board and an
officer of the Company,  loaned the Company $1,500,000 evidenced by demand notes
bearing interest at 6% per year, and (b) Warren Levy and Ronald Levy,  directors
and officers of the  Company,  loaned the Company  $100,000  evidenced by demand
notes  bearing  interest at the Merrill Lynch Margin Loan Rate plus .25% (8.625%
at June 30,  1999) (the  "Floating  Rate").  In July 1999,  Jay Levy  loaned the
Company an additional $370,000 evidenced by term notes maturing January 2002 and
bearing  interest at 6% per year, and the $1,500,000 of demand notes  evidencing
loans made by Jay Levy in the second  quarter were  converted into 6% term notes
maturing  January 2002. The Company has granted Jay Levy a security  interest in
all of its equipment  and a mortgage on its real  property to secure  payment of
the term notes  which are senior to all notes  payable to Warren Levy and Ronald
Levy.  The Company is required  to make  installment  payments on the term notes
commencing in October 1999 and ending in January 2002 in an aggregate  amount of
$72,426  per month.  Jay Levy has agreed to postpone  the  October and  November
installment payments.

In August 1999,  the Company and  Warner-Lambert  successfully  concluded  their
second pilot human study for their oral calcitonin  formulation,  resulting in a
payment to the  Company of $2.5  million.  In  September  1999,  the Company and
Warner-Lambert  identified an oral  calcitonin  formulation  to be used in their
upcoming Phase I clinical study entitling the Company to a milestone, payable in
installments,  totaling  $4.5  million.  The first  installment  of $500,000 was
received in September 1999, with payment of an additional  $500,000 due every 90
days  thereafter,  with the unpaid  balance  payable upon the  initiation of the
Phase I study, which the Company expects to occur in the first half of 2000. Due
to the  completion of this milestone in September  1999, the Company  recognized
$4.5  million as revenue in the third  quarter;  $2 million  was  recorded  as a
current  contract  receivable  and an  additional  $2 million was  recorded as a
non-current contract receivable.
<PAGE>
With the receipt of almost $2 million in stockholder loans during the second and
third  quarters of 1999,  in addition to an  aggregate of $3 million in payments
from  Warner-Lambert in the third quarter,  management believes that the Company
will have  sufficient  financial  resources  to sustain  its  operations  at the
current level into the fourth  quarter of 1999.  The Company  expects to receive
$500,000 from  Warner-Lambert  in December 1999, and $3.5 million in one or more
payments in the first half of 2000 from the  milestone  completed  in  September
1999.  The  Company  also  expects to achieve  additional  milestones  under the
Warner-Lambert  agreement  during 2000,  which will result in further  payments.
However,  there can be no  assurance  as to when or if the Company  will achieve
such milestones.  The Company is currently pursuing licensing agreements for its
nasal  and  injectable  calcitonin  products.  These  agreements  could  provide
short-term  funds  to the  Company  in  upfront  payments  as well as  milestone
payments.  The  Company  has  executed  an  agreement  for the sale of state tax
benefits,  to  yield  approximately  $4  million,  under a New  Jersey  Economic
Development Authority program, which allows certain New Jersey taxpayers to sell
their  state tax  benefits  to  third-parties.  However,  the  proceeds  will be
received  over the next few years and the size and timing of such  proceeds  are
subject to the  continued  funding of the  program by the State of New Jersey as
well as limitations based on the level of participation by other companies.  The
Company's  application  for the sale was  approved  by the New  Jersey  Economic
Development  Authority  in October  1999 and the  Company  expects to receive at
least $1  million  in the  first  year's  allocation.  However,  there can be no
assurance  that any of these  transactions  will be completed  or, if completed,
that the terms and timing of such transactions would provide sufficient funds to
sustain operations at the current level.

While the Company  believes that the  transactions  it currently is pursuing and
the  milestone  payments  under the  Warner-Lambert  agreement  will satisfy the
Company's  liquidity  requirements  in the near term,  satisfying  the Company's
long-term liquidity  requirements will require the successful  commercialization
of its nasal or oral calcitonin product. In addition,  the  commercialization of
its  calcitonin  products will require the Company to incur  additional  capital
expenditures,   including  expenditures  to  expand  or  upgrade  the  Company's
manufacturing   operations  to  satisfy   certain  of  its   calcitonin   supply
obligations.  However,  neither the cost nor timing of such capital expenditures
is determinable at this time.

YEAR 2000

The  Company has  established  a Year 2000  taskforce  that is  responsible  for
identifying  and reviewing all of the Company's  internal  computer  systems for
Year 2000 compliance,  including  workstations,  the accounting  system, and the
control  systems for equipment in the  Company's  manufacturing  and  laboratory
facilities.  The taskforce has reviewed and tested all critical and non-critical
systems for Year 2000 compliance.  All critical systems,  such as the accounting
and  telephone  systems have been brought  into  compliance  so that the Company
believes that its business will not be adversely affected by the non-performance
of these systems. Of the non-critical workstations tested and found not to be in
compliance,  most have been  updated to be  compliant.  The  Company  intends to
repair or  replace  the few  remaining  non-critical  noncompliant  systems in a
timely manner. To date, the costs of remediation have not been material.
<PAGE>
The Company has no material  relationships  with third-party  suppliers,  to the
extent that third-party  noncompliance could seriously disrupt  operations.  The
Company could be significantly  affected by Year 2000  noncompliance on the part
of  Warner-Lambert  as the Company  currently is dependent upon timely milestone
payments from Warner-Lambert. In addition, the loss of the utility supply to the
Company's  laboratory,  production and  administrative  facilities would cause a
shut down of those facilities which, depending on the duration of the shut down,
may have a material adverse impact on the Company's business.  In addition,  the
loss of  telecommunications  services and banking services would, as is the case
with all businesses, adversely affect the Company.

OTHER

The Company's  Common Stock has been delisted  from the Nasdaq  National  Market
System  effective  October 5, 1999 and is now trading on the OTC Bulletin Board.
The stock price has been adversely affected,  but the impact on the liquidity of
the stock has not yet been  determined.  The  Company  has filed an appeal  with
Nasdaq to review the delisting decision. However, the ultimate resolution of the
hearing is unknown.

In June 1998,  the  Financial  Accounting  Standards  Board issued SFAS No. 133,
"Accounting For Derivative  Instruments and Hedging  Activities." This statement
establishes  accounting  and  reporting  standards for  derivative  instruments,
including certain derivative  instruments  embedded in other contracts,  and for
hedging  activities.  SFAS  No.  133,  as  amended,  will be  effective  for the
Company's fiscal year beginning January 1, 2001. The adoption of SFAS No. 133 is
not expected to have a material  effect on the Company's  financial  position or
results of operations.

Item 3.      Quantitative and Qualitative Disclosures About Market Risk

MARKET RISK

In the normal  course of  business,  the Company is exposed to  fluctuations  in
interest  rates as the Company seeks debt  financing to sustain its  operations.
The  Company  does not use  derivative  instruments  or  hedging  to manage  its
exposures.

The information below summarizes the Company's market risks associated with debt
obligations  as of September  30, 1999.  Fair values  included  herein have been
estimated taking into  consideration the nature and terms of each instrument and
the  prevailing  economic and market  condition at September 30, 1999. The table
below  presents  principal  cash  flows and  related  interest  rates by year of
maturity  based on the terms of the debt.  The  information  presented as to the
convertible  debentures is without  consideration as to conversion features,  as
the  Company  is  unable to  predict  if and when such  conversions  may  occur.
Variable interest rates disclosed represent the rates at September 30, 1999.
<PAGE>
<TABLE>
<CAPTION>
                                          Estimated                                            Year of Maturity
                                             Fair             Carrying                         ----------------
                                            Value              Amount              1999        2000        2001       2002   2003
                                            ------             ------              ----        ----        ----       ----   ----
<S>                                      <C>                 <C>                <C>          <C>         <C>         <C>      <C>
Notes payable - stockholders             $1,140,000          1,140,000        1,140,000         --          --         --     --
Variable interest rate                                                        8.625%            --          --         --     --

Notes payable - stockholders             $1,870,000          1,870,000          171,922      788,684     837,328     72,066   --
Fixed interest rate                                                               6%           6%          6%         6%

5% convertible debentures                $2,800,000          2,800,000              --          --     2,800,000       --     --
Fixed interest rate (1)                                                             5%           5%        5%          --     --
</TABLE>
(1)  At the  option of the  Company,  interest  payments  may be made  using the
     Company's Common Stock.
<PAGE>
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

Certain  statements in this Form 10-Q  constitute  "forward-looking  statements"
within the meaning of the Private Securities  Litigation Reform Act of 1995 (the
"Reform Act"). Such forward-looking  statements involve known and unknown risks,
uncertainties  and other factors that may cause the actual results,  performance
or activities of the Company,  or industry results,  to be materially  different
from any future results,  performance or activities expressed or implied by such
forward-looking  statements. Such factors include: general economic and business
conditions, the financial condition of the Company, including the Company's need
for and success in securing  additional  financing,  competition,  the Company's
dependence on other  companies to  commercialize,  manufacture and sell products
using the Company's technologies,  the uncertainty of results of preclinical and
clinical testing, the risk of product liability and liability for human clinical
trials,  the  Company's  dependence  on patents  and other  proprietary  rights,
dependence on key management  officials,  the  availability and cost of capital,
the  availability of qualified  personnel,  changes in, or the failure to comply
with,  governmental  regulations,  the failure to obtain regulatory approvals of
the  Company's  products and other factors  discussed in the  Company's  various
filings with the  Securities  and Exchange  Commission,  including the Company's
Annual Report on Form 10-K for the year ended December 31, 1998.

PART II. OTHER INFORMATION

Item 2.  Changes in Securities and Use of Proceeds

(a)      Not applicable.

(b)      Not applicable.

(c)      Recent Sales of Unregistered Securities.

In July 1999,  the Company  issued  95,853  shares of Common Stock as payment of
approximately  $90,000 in  accrued  interest  on the  Company's  5%  Convertible
Debentures  due December 31, 2001. All of such shares were issued by the Company
without  registration  in reliance on an  exemption  under  Section 4 (2) of the
Securities Act.

(d)      Not applicable.
<PAGE>
Item 6.           Exhibits and Reports on Form 8-K

         (a)      Exhibits:

                  Exhibit 10.1      Amended and Restated Secured Note dated July
                                    13, 1999.
                  Exhibit 10.2      Amended  and  Restated  Security   Agreement
                                    dated July 13, 1999.
                  Exhibit 10.3      Subordination Agreement dated July 13, 1999.
                  Exhibit 10.4      Mortgage and Security  Agreement  dated July
                                    13, 1999.
                  Exhibit 10.5      $70,000 Secured Note dated July 30, 1999.
                  Exhibit 10.6      $200,000 Secured Note dated August 5, 1999.
                  Exhibit 10.7      Modification   of  Mortgage   and   Security
                                    Agreement dated August 5, 1999.
                  Exhibit 10.8      Amendment to Security Agreement and
                                    Subordination  Agreement between the Company
                                    and Jay Levy,  Warren  Levy and Ronald  Levy
                                    dated August 5, 1999.
                  Exhibit-27        Financial   Data  Schedule  -  period  ended
                                    September 30, 1999.

         (b)      Reports on Form 8-K:

The Company did not file any reports on Form 8-K during the three  months  ended
September 30, 1999.
<PAGE>
                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.

                                                    UNIGENE LABORATORIES, INC.
                                                    -----------------------
                                                    (Registrant)

                                                    /s/ Warren P. Levy
November 15, 1999                                   -----------------------
                                                    Warren P. Levy, President
                                                    (Chief Executive Officer)


                                                    /s/ Jay Levy
November 15, 1999                                   -----------------------
                                                    Jay Levy, Treasurer
                                                    (Chief Financial Officer and
                                                    Chief Accounting Officer)

                                                                    Exhibit 10.1
                        AMENDED AND RESTATED SECURED NOTE

$1,600,000.00                                                      July 13, 1999

         THIS AMENDED AND  RESTATED  SECURED NOTE (the "Note") is made as of the
13th day of July,  1999 by Unigene  Laboratories,  Inc., a Delaware  corporation
(the  "Company"),  in favor and for the  benefit of Jay Levy,  a resident of New
Jersey (the "Lender").
                                   WITNESSETH:

         WHEREAS,  the Lender has  heretofore  made the  following  loans to the
Company: (i) a loan in the amount of $200,000 on May 5, 1999, (ii) a loan in the
amount of  $200,000 on May 24,  1999,  (iii) a loan in the amount of $200,000 on
June7, 1999 (the loans identified in clauses (i), (ii), and (iii), collectively,
the "Prior  Loans"),  (iv) a loan in the amount of $200,000 on June 25, 1999, as
evidenced by that certain secured promissory note dated June 25, 1999, issued by
the  Company  to the  Lender  (the  "June 25 Note")  and  secured  by a security
interest in certain of the Company's equipment and real property,  (v) a loan in
the amount of $350,000 on June 29, 1999,  as  evidenced by that certain  secured
promissory  note dated June 29,  1999,  issued by the Company to the Lender (the
"June 29 Note") and secured by a security  interest in certain of the  Company's
equipment and real  property,  and (vi) a loan in the amount of $350,000 on June
30, 1999, as evidenced by that certain  secured  promissory  note dated June 30,
1999,  issued by the Company to the Lender (the "June 30 Note") and secured by a
security interest in certain of the Company's equipment and real property; and

         WHEREAS,  as of the date  hereof the  aggregate  amount of accrued  and
unpaid  interest on the Prior Loans,  the June 25 Note, the June 29 Note and the
June 30 Note is $6,994 (the "Accrued Interest"); and

         WHEREAS, on the date hereof the Lender has loaned to the
Company an additional $100,000 (the "New Loan"); and

         WHEREAS,  the parties  desire to  document  the Prior Loans and the New
Loan,  and to amend and restate in their  entirety the June 25 Note, the June 29
Note and the June 30 Note, all on the terms set forth herein.

         NOW, THEREFORE, in consideration of the mutual promises made herein and
for other good and valuable consideration,  the receipt and sufficiency of which
is hereby acknowledged, the parties hereto agree as follows:

         FOR VALUE RECEIVED,  the  undersigned,  Unigene  Laboratories,  Inc., a
Delaware  corporation,  promises to pay to the order of Jay Levy,  or the holder
hereof (the "Holder"),  on January 13, 2002 (the "Maturity Date"), the principal
sum of One Million Six Hundred  Thousand Dollars  ($1,600,000.00),  or, if less,
the unpaid  principal  amount  outstanding at such time, in either case together
with all accrued and unpaid interest thereon.
<PAGE>
         1. Surrender and Cancellation of Notes

                  Simultaneously  with the  execution  and  delivery  hereof the
Lender is surrendering to the Company the June 25 Note, the June 29 Note and the
June 30 Note,  which shall be marked  "superseded  by that  certain  Amended and
Restated  Secured  Note,  dated  July  13,  1999,  in the  principal  amount  of
$1,600,000."

         2. Security

                  The due and punctual payment by the Company of all amounts due
hereunder is secured by that certain  Mortgage of even date  herewith  issued by
the Company to the Lender (the "Mortgage") and that certain Amended and Restated
Security Agreement of even date herewith between the Company, the Lender, Warren
P. Levy and Ronald S. Levy (the "Security Agreement").

         3. Interest

         (a)      The  Company  promises  to pay to the Holder  interest  on the
unpaid  principal amount hereof from the date hereof at a rate of six percent (6
%) per year, compounded monthly.

         (b)      Interest  on this  Note  shall be  computed  on the basis of a
365-day year.

         4.       Payments

         (a)      On  October  13,  1999,  the  Company  shall pay to the Holder
$6,994 as full payment of the Accrued Interest.

         (b)      Commencing October 13, 1999, and on the 13th day of each month
thereafter through and including the Maturity Date, the Company shall pay to the
Holder the lesser of (i) $61,993.99 and (ii) the  outstanding  principal  amount
hereof plus all accrued and unpaid interest hereon.

         (c)      This Note may be prepaid by the Company,  in whole or in part,
at any time and from time to time without  premium or penalty.  All  prepayments
shall be credited first to accrued and unpaid interest and then to principal.

         (d)      All payments by the Company  hereunder  shall be made by check
not later than 5:00 p.m. Eastern time on the day when due.  Whenever any payment
to be made pursuant to this Note shall be stated to be due on a public  holiday,
Saturday or Sunday,  such  payment may be made on the next  succeeding  business
day.  Such  extension  of time shall not be  included in  computing  interest in
connection with such payment.

         5. Events of Default

         (a)      An  "Event of  Default"  shall  exist if any of the  following
occurs and is continuing:
<PAGE>
                  (i)      the  Company  fails to make any  payment on this Note
when such payment is due and such default shall  continue for more than ten (10)
business days;

                  (ii)     the  Company  fails to comply  with or  breaches  any
material provision of the Mortgage or the Security Agreement and such failure or
breach  continues  for more than  thirty  (30) days  after the  Holder has given
written notice of such failure to the Company; or

                  (iii)    a receiver,  custodian,  liquidator or trustee of the
Company,  or of any of  the  property  of  the  Company  or any of its  material
subsidiaries, is appointed by court order; or the Company or any of its material
subsidiaries is adjudicated bankrupt or insolvent; or any of the property of the
Company or any of its material  subsidiaries is sequestered by court order; or a
petition to reorganize the Company or any of its material subsidiaries under any
bankruptcy, reorganization or insolvency law is filed against the Company or any
of its material  subsidiaries  and is not dismissed within sixty (60) days after
such  filing;  or  the  Company  or any of its  material  subsidiaries  files  a
voluntary bankruptcy petition or requesting  reorganization or arrangement under
any provision of any bankruptcy,  reorganization  or insolvency law, or consents
to the filing of any  petition  against it under any such law; or the Company or
any of its material  subsidiaries  makes a general assignment for the benefit of
its creditors,  or admits in writing its inability to pay its debts generally as
they  become  due, or  consents  to the  appointment  of a receiver,  trustee or
liquidator of the Company or any of its material  subsidiaries  or of all or any
part of the property of the Company or any of its material subsidiaries.

         (b)      If an Event of Default occurs under Section 5(a)(i), then this
Note shall accrue  additional  interest on all unpaid  amounts of principal  and
interest  from the date of the Event of Default at a rate equal to the lesser of
(i) eleven percent (11%) per annum or (ii) the highest amount allowable by law.

         (c)      If an Event of Default  exists,  then the Holder may  exercise
any right, power or remedy conferred upon it by law, and shall have the right to
declare by written notice the entire  principal and all interest accrued on this
Note to be, and such Note shall thereupon become,  forthwith due and payable and
the Company shall  immediately  pay to the Holder of this Note the entire unpaid
principal and interest accrued on this Note.

         (d)      In the case of an Event of Default, the Company, to the extent
permitted by law,  waives  presentment,  demand,  notice,  protest and all other
demands or notices in connection with the enforcement of this Note.

         6.       Miscellaneous.

         (a)      No delay or omission by the Holder  hereof in  exercising  any
right or remedy hereunder shall constitute a waiver of any such right or remedy.
A waiver on one  occasion  shall not  operate  as a bar to or waiver of any such
right or remedy on any future occasion.

         (b)      The Company  shall pay all  reasonable  costs and  expenses of
collection,  including attorney's fees, incurred or paid by the Holder hereof in
enforcing this Note and the obligations evidenced hereby.
<PAGE>
         (c)      This Note may be  amended  only by  written  agreement  of the
Company and the Holder hereof.

         (d)      This Note  shall be  governed  by the laws of the State of New
Jersey without regard to its choice of law provisions.

         (e)      In the event that the Holder  notifies  the Company  that this
Note has been  mutilated,  lost,  stolen or destroyed,  the Company will issue a
replacement  Note  identical in all  respects to the  original  Note (except for
registration number and the then outstanding principal amount, if different than
that  shown on the  original  Note),  provided  that the Holder  surrenders  for
cancellation  its Note  certificate  in the case of a mutilated  certificate  or
provides  evidence  of  lost,  theft or  destruction  and  indemnity  reasonably
satisfactory  to  the  Company  in the  case  of a  lost,  stolen  or  destroyed
certificate .

         (f)      The Holder may mortgage,  encumber,  transfer or assign any of
its  rights or  interest  in and to this Note or any part  hereof  and,  without
limitation,  each  assignee,  transferee  and  mortgagee  (which may include any
affiliate of the Holder) shall have the right to so mortgage, encumber, transfer
or assign its  interest.  The Company may not assign its  obligations  hereunder
without the prior written  consent of the Holder,  except that without the prior
written  consent of the Holder,  but after  notice  duly given,  the Company may
assign its obligations hereunder to any successor-in-interest corporation in the
event  of a  merger  or  consolidation  of the  Company  with  or  into  another
corporation,  or the sale of all or substantially  all of the Company's  assets.
The Note shall in all cases be binding on the  Company  and its  successors  and
assigns and inure to the benefit of the Holder and its successors and assigns.

         IN WITNESS WHEREOF, the Company and the Lender have caused this Note to
be executed and delivered as of the day and year first written above.

                                               UNIGENE LABORATORIES, INC.

                                               By:
                                                   ----------------------


                                               Title:
                                                     --------------------

[Corporate Seal]

                                               --------------------------
                                               JAY LEVY

                                                                    Exhibit 10.2
                     AMENDED AND RESTATED SECURITY AGREEMENT

         THIS AMENDED AND  RESTATED  SECURITY  AGREEMENT  (the  "Agreement")  is
entered  into this 13th day of July,  1999 by and  among  UNIGENE  LABORATORIES,
INC.,  a Delaware  corporation,  having its  principal  place of business at 110
Little  Falls Road,  Fairfield,  New Jersey 07004 (the  "Company"),  Jay Levy, a
resident of New Jersey,  Warren P. Levy, a resident of New Jersey, and Ronald S.
Levy, a resident of New Jersey.  Jay Levy, Warren P. Levy and Ronald S. Levy are
sometimes  individually  referred  to  as a  "Secured  Party"  and  collectively
referred to as "Secured Parties."
                                   WITNESSETH:

         WHEREAS,  on March 2, 1995,  the  Secured  Parties  loaned the  Company
$500,000,  as evidenced by that certain  promissory  note,  dated as of March 2,
1995, (the "March 2 Note"); and

         WHEREAS,  in order to secure the  payment by the Company of the March 2
Note, on March 2, 1995,  the Company and the Secured  Parties  entered into that
certain  Security  Agreement  pursuant to which the Company  granted the Secured
Parties a security  interest  in its  equipment  located at its  premises at 110
Little Falls Road,  Fairfield,  New Jersey (the  "Fairfield  Equipment"),  which
agreement was amended by that certain  Amendment to Loan  Agreement and Security
Agreement,  dated March 20,  1995,  pursuant  to which the  Company  granted the
Secured Parties a security  interest in its equipment located at its premises at
83 Fulton Street, Boonton, New Jersey (the "Boonton Equipment"); and

         WHEREAS,  the security  interest in the Fairfield  Equipment granted by
the Company to the Secured  Parties was  perfected  by the filing of a financing
statement with respect thereto in Essex County, New Jersey on February 27, 1995;
and

         WHEREAS,  on June 29,  1995,  the  Secured  Parties  loaned the Company
$700,000,  as evidenced by that certain  promissory  note,  dated as of June 29,
1995, (the "June 29, 1995 Note"); and

         WHEREAS,  the  Company  and the  Secured  Parties  further  amended the
Security  Agreement  pursuant to that certain  Amendment to Loan  Agreement  and
Security Agreement,  dated March 20, 1995, in order to secure the payment by the
Company of the June 29, 1995 Note; and

         WHEREAS,  on June 25, 1999,  Jay Levy loaned the Company  $200,000,  as
evidenced by that certain promissory note, dated as of June 25, 1999, (the "June
25 Note"); and

         WHEREAS,  the  Company  and the  Secured  Parties  further  amended the
Security  Agreement  pursuant to that certain  Amendment to Loan  Agreement  and
Security  Agreement,  dated June 25, 1999, in order to secure the payment by the
Company of the June 25 Note; and

         WHEREAS,  on June 29, 1999,  Jay Levy loaned the Company  $350,000,  as
evidenced by that certain promissory note, dated as of June 29, 1999, (the "June
29, 1999 Note"); and
<PAGE>
         WHEREAS,  the  Company  and the  Secured  Parties  further  amended the
Security  Agreement  pursuant to that certain  Amendment to Loan  Agreement  and
Security  Agreement,  dated June 29, 1999, in order to secure the payment by the
Company of the June 29, 1999 Note; and

         WHEREAS,  on June 30, 1999,  Jay Levy loaned the Company  $350,000,  as
evidenced by that certain promissory note, dated as of June 30, 1999, (the "June
30 Note"); and

         WHEREAS,  the  Company  and the  Secured  Parties  further  amended the
Security  Agreement  pursuant to that certain  Amendment to Loan  Agreement  and
Security  Agreement,  dated June 30, 1999, in order to secure the payment by the
Company of the June 30 Note; and

         WHEREAS,  Jay  Levy  has made  the  following  additional  loans to the
Company: (i) a loan in the amount of $200,000 on May 5, 1999, (ii) a loan in the
amount of $200,000 on May 24,  1999,  and (iii) a loan in the amount of $200,000
on June 7, 1999 (collectively, the "Prior Loans"); and

         WHEREAS,   Jay  Levy  has   agreed   to  loan  the   Company   $100,000
contemporaneously with the execution and delivery hereof (the "New Loan"); and

         WHEREAS,  in order to induce  Jay Levy to make the Prior  Loans and the
New  Loan,  the  Company  has  agreed to grant him a  security  interest  in the
Collateral  (as defined  below) to secure  payment of the New Loan and the Prior
Loans and a mortgage on certain real property owned by the Company at 110 Little
Falls Road, Fairfield, New Jersey; and

         WHEREAS,  in order to document  the New Loan and the Prior Loans and to
amend and restate the June 25 Note, the June 29, 1999 Note and the June 30 Note,
the Company  contemporaneously with the execution and delivery hereof will issue
and deliver to Jay Levy that  certain  Amended and Restated  Secured  Promissory
Note in the principal  amount of $1,600,000  (the "Restated  Note") and Jay Levy
will in exchange for the Restated Note  surrender the June 25 Note, the June 29,
1999 Note and the June 30 Note; and
<PAGE>
         WHEREAS,  the parties desire to document the security  interest granted
to Jay Levy to secure payment of the New Loan and the Prior Loans,  and to amend
and restate the Security Agreement,  as heretofore amended, in its entirety, all
on the terms set forth herein.

         NOW, THEREFORE, in consideration of the mutual promises made herein and
for other good and valuable consideration,  the receipt and sufficiency of which
is hereby acknowledged, the parties hereto agree as follows:

1.       Definitions.  The  following  terms  when used  herein  shall  have the
         following definitions:

         1.1      "Collateral"   shall  mean  (a)  all   laboratory   equipment,
manufacturing  equipment,  office  machinery,  tools,  materials,   storage  and
handling   equipment,   computer  equipment  and  hardware,   including  central
processing units, terminals, drives, memory units, printers, keyboards, screens,
peripherals and input or output  devices,  and other equipment of every kind and
nature,  wherever  situated,  now or  hereafter  owned by the  Company,  (b) all
additions,  accessions,  replacements,  accessories  and parts in respect of the
foregoing,  all  manuals,  blueprints,  warranties  and  records  in  connection
therewith, all rights against suppliers, warrantors,  manufacturers,  sellers or
others in connection therewith,  and all substitutions for any of the foregoing,
(c) all books and records, in whatever form, owned by the Company related to the
foregoing, and (d) all proceeds of any of the foregoing.

         1.2      "Event of Default" shall mean:

                  (a) an "Event of Default" as defined in the Restated Note;

                  (b) any occurrence specified in Section 3 of the March 2 Note;

                  (c) any occurrence specified in Section 3 of the June 29, 1995
                  Note; or

                  (d) any material breach of representation  made by the Company
                  in Section 5 hereof.

         1.3      "Obligations"  shall mean all  indebtedness,  obligations  and
liabilities  of every kind and nature of the Company now or  hereafter  existing
under or arising out of or in  connection  with the Restated  Note,  the March 2
Note, the June 29, 1995 Note and this Agreement and all  extensions,  amendments
or renewals  hereof or thereof,  whether for principal,  premium,  interest,  or
fees,  and all or any portion of such  indebtedness,  obligations or liabilities
that are  paid to the  extent  all or any part of such  payment  is  avoided  or
recovered  directly  or  indirectly  from  a  Secured  Party  as  a  preference,
fraudulent transfer or otherwise.

2. Grant of Security.  As security for the due and punctual  performance  of the
Obligations,  the  Company  hereby (a) grants to the  Secured  Parties,  for the
ratable benefit of the Secured  Parties,  a security  interest in the Collateral
and (b) reaffirms all prior grants to the Secured Parties of security  interests
in the Collateral.
<PAGE>
3.  Release and Satisfaction.

         3.1. Upon the termination of this Agreement,  the Secured Parties shall
promptly  deliver to the Company  upon  request  therefor  and at the  Company's
expense,  releases  and  satisfactions  of all  financing  statements  and other
registrations of security.

         3.2.  The Company  from time to time may sell all or any portion of the
Collateral;  provided that such sale is an arm's length transaction with a party
that is not an affiliate of the Company and that the Collateral is sold for fair
value;  provided  further  that the  proceeds  from such sale  shall be  applied
ratably to the payment of the Obligations to the extent thereof.

4. Location of  Collateral.  The Collateral is located at 110 Little Falls Road,
Fairfield,  New Jersey or 83 Fulton Street,  Boonton, New Jersey. So long as any
Obligations  shall  be  outstanding,  the  Company  shall  not  move  any of the
Collateral  having an aggregate  book or market value in excess of $5,000 to any
location  other than 110 Little Falls Road,  Fairfield,  New Jersey or 83 Fulton
Street,  Boonton,  New Jersey,  unless the Company  shall have given the Secured
Parties  ten  (10)  day's  prior  written  notice  of  its  intention  to do so,
identifying the new location.

5. Representations and Warranties. The Company hereby represents and warrants to
the Secured Parties that, as of the date hereof:

         5.1. The Company owns all of the Collateral free and clear of any lien,
encumbrance,  mortgage,  security  agreement,  pledge or charge other than (i) a
security interest in the Collateral granted to Jean Levy to secure a loan in the
principal amount of $650,000 and (ii) security  interests  heretofore granted to
the Secured Parties.

         5.2. The Company is a corporation duly  incorporated,  validly existing
and in good  standing  under  the  laws of the  State  of  Delaware  and has all
requisite  corporate  power and  authority  to carry on its business and own its
properties  as now  conducted  and owned.  The Company is duly  qualified  to do
business  as a  foreign  corporation  and in good  standing  in the State of New
Jersey.

         5.3.  The Company has full  corporate  power and  authority to execute,
deliver and perform this Agreement and has taken all requisite  corporate action
necessary for (i) the  authorization,  execution and delivery of this  Agreement
and (ii) the  performance  of all  obligations  of the Company  hereunder.  This
Agreement  constitutes the legal,  valid and binding  obligation of the Company,
enforceable  against the  Company in  accordance  with its terms  except as such
enforcement   may  be  limited  by  (a)   applicable   bankruptcy,   insolvency,
reorganization,  voidable  preference,  fraudulent  conveyance and other similar
laws  affecting  the  rights or  remedies  of  creditors  generally  and (b) the
exercise of judicial  discretion in accordance with general principles of equity
(whether applied by a court of law or equity).
<PAGE>
6. Further Actions. The Company agrees that from time to time, at the expense of
the  Company,  the  Company  will  promptly  execute  and  deliver  all  further
instruments  and  documents  and take all further  action that any Secured Party
reasonably may request in order to perfect the security interest granted hereby,
including the execution,  recording and filing of such financing or continuation
statements,  or amendments  thereto,  and such other  instruments,  documents or
notices, as a Secured Party reasonably may request.

7. Covenants. During the term hereof, the Company shall:

     (a) not use or permit any Collateral to be used  unlawfully or in violation
of any  provision of this  Agreement or any  applicable  statute,  regulation or
ordinance or any policy of insurance covering the Collateral;

     (b)  maintain the Collateral in good working condition;

     (c) maintain insurance reasonably believed by Company to be adequate on all
Collateral of a type customarily  insured by companies similarly situated to the
Company, covering property damage and loss of income by fire or other casualty;

     (d) pay promptly  when due all property  and other taxes,  assessments  and
governmental  charges or levies imposed upon, and all claims  (including  claims
for labor, materials and supplies) against, the Collateral, except to the extent
the validity thereof is being contested in good faith;

     (e) not sell,  assign  (by  operation  of law or  otherwise)  or  otherwise
dispose of any of the Collateral,  except (i) as permitted by this Agreement and
(ii) that the Company may dispose of Collateral that has become obsolete; and

     (f) keep reasonable records respecting the Collateral and at all times keep
at least one complete set of its records concerning all of the Collateral at its
chief executive office or principal place of business.

7.  Inspection.  Any Secured Party may examine and inspect the  Collateral  upon
reasonable prior notice during the Company's normal business hours.

8. Secured  Parties May Perform.  If the Company  fails to perform any agreement
contained  herein,  each Secured Party may itself perform,  or cause performance
of,  such  agreement,  and  the  expenses  of such  Secured  Party  incurred  in
connection therewith shall be reimbursed by the Company promptly.

9. Enforcement.  Upon the occurrence of any Event of Default, each Secured Party
shall have, in addition to all of its other rights under this Agreement,  all of
the rights and remedies of a secured party under the Uniform Commercial Code.

10.  Termination.  This  Agreement  shall  terminate  at such time as all of the
Obligations  shall have been  indefeasibly  fully paid and satisfied  and, until
such time, the Secured  Parties shall retain all security in the Collateral held
by them hereunder.
<PAGE>
11. Binding  Effect.  This  Agreement  shall be binding upon the Company and its
successors and assigns and shall inure to the benefit of the Secured Parties and
their respective heirs, executors, administrators, successors and assigns.

12. Notices.  Unless otherwise provided,  any notice required or permitted under
this Agreement shall be given in writing and shall be deemed  effectively  given
(i) on the  same  day if  given  by  personal  delivery,  (ii) on the  following
business day if given by telecopier with  confirmation  of receipt,  or (iii) on
the  following  business day if given by  nationally  recognized  overnight  air
courier, in each case addressed to the party to be notified at:

         110 Little Falls Road
         Fairfield, New Jersey, 07004,
         Attention: [Name of Party]
         Facsimile: 973-227-6088

or at such  other  address  as such  party may  designate  by ten days'  advance
written notice given hereunder to any other party.

13.  Waiver.  No delay or failure on the part of any Secured Party in exercising
any right,  privilege,  remedy or option  hereunder shall operate as a waiver of
such or any other  right,  privilege,  remedy or option,  and no waiver shall be
valid  unless in writing and signed by each  Secured  Party and then only to the
extent therein set forth.

14.  Modifications  and  Amendments.  This  Agreement  constitutes  the complete
agreement  between the parties  with  respect to the subject  matter  hereof and
supersedes all prior agreements with respect thereto.  This Agreement may not be
changed, modified or amended orally, but only by a writing signed by all parties
hereto.

         15.  Applicable  Law. This  Agreement  shall be construed in accordance
with and governed by the laws of the State of New Jersey  without  giving effect
to conflicts of laws principles.

         16.  Counterparts.  This  Agreement  may be  executed  in  two or  more
counterparts,  each of which shall constitute an original and all of which shall
constitute the same instrument.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be executed on the day and year first above written.
<PAGE>
                                            UNIGENE LABORATORIES, INC.

                                            By:
                                                     Name:
                                                     Title:

                                            ------------------------------------
                                            JAY LEVY

                                            ------------------------------------
                                            WARREN P. LEVY

                                            ------------------------------------
                                            RONALD S. LEVY



                                                                    Exhibit 10.3

                             SUBORDINATION AGREEMENT

         THIS  SUBORDINATION  AGREEMENT (the  "Agreement")  is entered into this
13th day of July by and among Unigene Laboratories, Inc., a Delaware corporation
(the "Company"),  Jay Levy, a resident of New Jersey, Warren P. Levy, a resident
of New Jersey,  and Ronald S. Levy, a resident of New Jersey (Warren P. Levy and
Ronald S. Levy are referred to herein individually as a "Subordinated  Creditor"
and collectively as the "Subordinated Creditors").

                                   WITNESSETH:

         WHEREAS,  Jay  Levy  and  the  Subordinated  Creditors  jointly  hold a
promissory  note (the  "March 2 Note"),  dated  March 2, 1995,  in the  original
principal amount of $500,000 issued by the Company; and

         WHEREAS,  Jay  Levy  and  the  Subordinated  Creditors  jointly  hold a
promissory  note (the "June 29  Note"),  dated June 29,  1995,  in the  original
principal amount of $700,000 issued by the Company; and

         WHEREAS,  the aggregate  principal  amount  outstanding and owed by the
Company  to Jay Levy  under the March 2 Note and the June 29 Note as of the date
hereof is $60,000 and the aggregate  amount of accrued and unpaid  interest owed
by the Company to Jay Levy under the March 2 Note and the June 29 Note as of the
date hereof is $103,541; and

         WHEREAS, Jay Levy holds a promissory note (the "Restated Note") of even
date herewith in the principal amount of $1,600,000 issued by the Company; and

         WHEREAS,  the  payment  of the  March 2 Note,  the June 29 Note and the
Restated Note are secured by a security  interest in the  Collateral  granted by
the Company to Jay Levy and the  Subordinated  Creditors  pursuant  that certain
Amended and Restated  Security  Agreement of even date herewith by and among the
Company, Jay Levy and the Subordinated Creditors (the "Security Agreement"); and

         WHEREAS, to induce Jay Levy to make certain of the loans to the Company
evidenced by the Restated Note, each of the Subordinated Creditors has agreed to
subordinate his security  interest in the Collateral to the security interest in
the Collateral granted to Jay Levy, all on the terms set forth herein.

         NOW, THEREFORE, in consideration of the mutual promises made herein and
for other good and valuable consideration,  the receipt and sufficiency of which
is hereby acknowledged, the parties hereto agree as follows:
<PAGE>
1.  Definitions.

         1.1 All terms used  herein  and not  defined  shall  have the  meanings
ascribed to such terms in the Security Agreement.

         1.2 The  following  terms when used  herein  shall  have the  following
meanings:
                  (a) "Senior  Debt" shall mean all  indebtedness,  liabilities,
and  obligations of the Company to Jay Levy under the Restated Note, the March 2
Note and the June 29 Note, including,  without limitation,  principal,  interest
(including  interest  accruing  after the  bankruptcy  of the  Company) and fees
payable thereunder.

                  (b)   "Subordinated   Debt"   shall  mean  all   indebtedness,
liabilities,  and obligations of the Company to the Subordinated Creditors under
the March 2 Note and the June 29 Note, including, without limitation, principal,
interest and fees payable thereunder.

2.  Subordination.  Each  Subordinated  Creditor  hereby agrees that any and all
liens on and  security  interests  in the  Collateral  granted  by the  Company,
whether pursuant to the Security  Agreement or otherwise,  to such  Subordinated
Creditor to secure any Subordinated Debt is hereby  immediately made subordinate
and  junior  to,  and  postponed  in  priority  and  effect to, the liens on and
security  interests  in the  Collateral  granted by the Company  pursuant to the
Security  Agreement to Jay Levy to secure the Senior Debt,  all as if Jay Levy's
security  interests  had  been  perfected  by the  timely  filing  of  financing
statements  or by any other legal means prior to the time the security  interest
with respect to the  Subordinated  Debt was perfected and prior to the filing of
any financing statements in connection with the Subordinated Debt.

3. Rights to Collect Prior to Subordinated Debt. In the event of, and commencing
with the date of, any dissolution,  winding up,  liquidation,  reorganization or
other similar proceeding relating to the Company,  its creditors or its property
(whether  voluntary  or  involuntary,   partial  or  complete,  and  whether  in
bankruptcy,  insolvency or  receivership,  or upon assignment for the benefit of
creditors, or any other marshalling of the assets and liabilities of the Company
or any sale of the assets of the Company), the Senior Debt shall be satisfied in
full in cash or otherwise to the reasonable  satisfaction of Jay Levy before the
Subordinated  Creditors  shall be entitled to receive and/or retain any payment,
distribution,  asset  or  other  property  of  the  Company  in  respect  of the
Subordinated  Debt and,  in order to  implement  the  foregoing,  all  payments,
distributions   or  transfers  of  property  of  any  kind  in  respect  of  the
Subordinated  Debt to which any Subordinated  Creditor would be entitled but for
the  provisions of this  Agreement  shall be made directly to Jay Levy (and each
Subordinated   Creditor  hereby  directs  any  person  making  such  payment  or
distribution to make such payment or distribution directly to Jay Levy).
<PAGE>
4. Postponement of Enforcement. Each Subordinated Creditor hereby agrees that he
shall not attempt to assert,  enforce or take any action in  furtherance  of any
rights or remedies granted pursuant to the Security  Agreement in respect of the
Subordinated  Debt unless and until the Senior Debt shall have been satisfied in
full in cash or otherwise to the reasonable  satisfaction of Jay Levy;  provided
that the foregoing  shall not terminate or otherwise  void the rights granted to
the Subordinated Creditors pursuant to the Security Agreement.

5. Further Assurances.  Each Subordinated  Creditor hereby agrees to execute any
and all such  further  agreements,  documents  and  instruments,  and to take or
refrain from taking any further  action,  as Jay Levy  reasonably may request to
carry into effect the intent of this Agreement.

6. Term.  This Agreement  shall remain in full force and effect until all Senior
Debt  has  been  satisfied  in  full  in cash  or  otherwise  to the  reasonable
satisfaction of Jay Levy.

7.  Binding  Effect.  This  Agreement  shall be binding upon the Company and the
Subordinated Creditors and their respective,  heirs, executors,  administrators,
successors and assigns and shall inure to the benefit of Jay Levy and his heirs,
executors, administrators, successors and assigns.

8. Notices.  Unless otherwise  provided,  any notice required or permitted under
this Agreement shall be given in writing and shall be deemed  effectively  given
(i) on the  same  day if  given  by  personal  delivery,  (ii) on the  following
business day if given by telecopier with  confirmation  of receipt,  or (iii) on
the  following  business day if given by  nationally  recognized  overnight  air
courier, in each case addressed to the party to be notified at:

         110 Little Falls Road
         Fairfield, New Jersey, 07004,
         Attention: [Name of Party]
         Facsimile: 973-227-6088

or at such  other  address  as such  party may  designate  by ten days'  advance
written notice given hereunder to any other party.

9. Waiver. No delay or failure on the part of any party in exercising any right,
privilege,  remedy or option  hereunder shall operate as a waiver of such or any
other right, privilege, remedy or option, and no waiver shall be valid unless in
writing and signed by each party and then only to the extent therein set forth.

10.  Modifications  and  Amendments.  This  Agreement  constitutes  the complete
agreement  between the parties  with  respect to the subject  matter  hereof and
supersedes all prior agreements with respect thereto.  This Agreement may not be
changed, modified or amended orally, but only by a writing signed by all parties
hereto.
<PAGE>
         11.  Applicable  Law. This  Agreement  shall be construed in accordance
with and governed by the laws of the State of New Jersey  without  giving effect
to conflicts of laws principles.

         12.  Severability.  If one or more provisions of this Agreement is held
to be unenforceable  under applicable law, such provision shall be excluded from
this Agreement and the balance of this Agreement shall be interpreted as if such
provision  were so excluded  and shall be  enforceable  in  accordance  with its
terms.

         13.  Counterparts.  This  Agreement  may be  executed  in  two or  more
counterparts,  each of which shall constitute an original and all of which shall
constitute the same instrument.
<PAGE>
                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be executed on the day and year first above written.

                                            UNIGENE LABORATORIES, INC.

                                            By:
                                              ----------------------------------
                                                Name:
                                                Title:

                                            ------------------------------------
                                            JAY LEVY

                                            ------------------------------------
                                            WARREN P. LEVY

                                            ------------------------------------
                                            RONALD S. LEVY

                                            Prepared by:

                                            -----------------------
                                            T. Thomas Van Dam, Esq.


Exhibit 10.4
                         MORTGAGE AND SECURITY AGREEMENT

         THIS  MORTGAGE  made  this  13th day of  July,  1999,  between  UNIGENE
LABORATORIES,  INC.,  a  Delaware  corporation,  having  an office at 110 Little
Falls Road, Fairfield,  New Jersey 07004 (herein called the "Mortgagor") and JAY
LEVY,  having an address  at 2150  Center  Avenue,  Fort Lee,  New Jersey  07024
(herein called the "Mortgagee").

                              W I T N E S S E T H:

         WHEREAS,  the  Mortgagor  is  now  indebted  to  the  Mortgagee  in the
principal  sum of ONE MILLION SIX HUNDRED  THOUSAND  and 00/100  ($1,600,000.00)
DOLLARS with interest thereon at the rates and times more particularly set forth
in a certain  Amended and Restated  Secured Note of even date  herewith from the
Mortgagor herein to the Mortgagee herein as Payee (the "Note"); and WHEREAS, the
Mortgagor  is the  owner in fee  simple  of a  certain  tract or  parcel of real
property and improvements  thereon located in the Township of Fairfield,  County
of Essex and State of New Jersey.

         NOW,  THEREFORE,  for the better  securing of the payment of the monies
owing on said Note and all  extensions  and renewals  thereof and  substitutions
therefor,  including other payments  mentioned therein for the protection of the
security as well as to secure the  repayment of all future  advances that may be
made by the Mortgagee to the Mortgagor with interest thereon as may from time to
time be agreed upon, the Mortgagor has granted, bargained, sold and conveyed and
by these presents does grant, and assigns,  ALL the following tract or parcel of
land and premises  located in the  ownership of  Fairfield,  County of Essex and
State of New Jersey, as more particularly described in Exhibit A attached hereto
and made a part hereof (hereafter referred to as the "Mortgaged Premises").

         TOGETHER  with  all and  singular  and  tenements,  hereditaments,  and
appurtenances thereunto belonging, or in anyway appertaining,  and the reversion
or reversions,  remainder and remainders; and also all the estate, right, title,
interest,  property,  possession, claim and demand whatsoever, in Law as well as
in Equity,  of the  Mortgagor,  of, in and to the same and every part and parcel
thereof,  with  appurtenances;  including  all fixtures  affixed to the same, or
intended so to be, and also all  equipment and  improvements  intended so to be,
and also all equipment and  improvements now in, upon, or which may hereafter be
installed  or  placed  in or upon the  same,  adapted  to or  necessary  for the
complete and conformable  use,  enjoyment or occupancy  thereof.  TO HAVE AND TO
HOLD,   the  above  granted  and   described   Mortgaged   Premises,   with  the
appurtenances, fixtures, equipment and improvements thereto, unto the Mortgagee,
its successors and assigns, to its and their own proper use and benefit forever.
PROVIDED ALWAYS, and these premises are upon the express condition,  that if the
Mortgagor  shall well and truly pay to the Mortgagee  all money  secured  hereby
when the same shall become due and payable,  without deduction or credit for any
amount  payable for taxes,  then these  presents and the estate  hereby  granted
shall cease, terminate and be void.
<PAGE>
THE MORTGAGOR REPRESENTS,  WARRANTS,  COVENANTS AND AGREES WITH THE MORTGAGEE AS
FOLLOWS:
               1. The Mortgagor  shall comply with all provisions  hereof and of
the Note evidencing the  indebtedness  secured hereby (which Note is made a part
hereof as if recited at length herein).

               2. The Mortgagor  shall pay to the Mortgagee said sum of money as
mentioned above and interest thereon and additions thereto,  as expressed in the
conditions of the Note.

               3. If requested by the Mortgagee,  the Mortgagor shall pay to the
Mortgagee at the time of each monthly payment, one-twelfth (1/12) of the current
annual taxes levied and assessed  against the  Mortgaged  Premises,  and one (1)
month's  proportion  of the insurance  premium,  to be held by the Mortgagee and
used in  payment  of the taxes and  insurance  premiums  as they  become due and
payable,  and the  Mortgagor  shall make such further tax or  insurance  reserve
payments  in such  amounts  and at such  time to  times as the  Mortgagee  shall
require,  and if not so  requested,  Mortgagor  shall  provide to  Mortgagee  as
requested  within twenty (20) days of the due date proof of payment of any taxes
or  assessments  levied or  assessed  against  the  Mortgaged  Premises  and any
insurance premiums due with regard to insurance of the Mortgaged Premises.

               4. The  Mortgagor  is  seized  of an  indefeasible  estate in fee
simple  in the  Mortgaged  Premises,  and the  Mortgagor  warrants  title to the
Mortgaged Premises subject to prior mortgages and security agreements of record.
<PAGE>
               5. The Mortgagor  shall keep any  buildings and other  structures
now or hereafter  erected upon the Mortgaged  Premises,  including  fixtures and
equipment,  insured against loss or damage by fire, and will insure against such
other hazards as Mortgagee may specify,  by insurers and in amounts  approved by
the  Mortgagee,  with  loss  payable  to  the  Mortgagee  as  mortgagee  and  as
co-insured,  and shall deliver said policy or policies to the Mortgagee;  and in
default thereof,  the Mortgagee may effect such insurance.  The Mortgagor hereby
assigns to the  Mortgagee  all rights to demand and  receive  all money  payable
under any of said  policies of  insurance,  or  certificates  of insurance  with
respect to public  liability  insurance,  and the rights to settle or compromise
all claims  thereunder,  and all money received may be applied on account of the
indebtedness  secured  hereby or used to repair or replace the  buildings on the
Mortgaged  Premises,  as the  Mortgagee  shall  elect.  In the  event of loss or
damage, the Mortgagor shall give immediate notice thereof to the Mortgagee.  The
Mortgagee may make proof of loss if not made promptly by the Mortgagor, and such
insurer is hereby  authorized  and  directed  to make  payment  for such loss or
damage  directly to the  Mortgagee  instead of the  Mortgagor  and the Mortgagee
jointly.  At least thirty (30) days prior to the expiration of any such policies
the Mortgagor  shall furnish  evidence  satisfactory  to the Mortgagee  that the
policies have been renewed or replaced or are no longer required.

               6. In the  event the  Mortgaged  Premises,  or any part  thereof,
shall be taken and  condemned  for public  purposes  by the proper  governmental
authorities, the Mortgagor shall have no claim against the award for damages, or
be entitled to any portion of the award until the entire indebtedness secured by
this Mortgage  shall be paid in full, and all rights to damages of the Mortgagor
are hereby assigned to the Mortgagee to the extent of the principal indebtedness
as remains unpaid (the Mortgagee, however, having the right to appeal said award
to the courts of competent  jurisdiction)  . The  satisfaction  of the principal
condemnation  award upon  exercise  of any  authority  with the right of eminent
domain shall constitute a prepayment to the full extent thereof.

                7.  The  Mortgagor  agrees  to  comply  with  all  laws,  rules,
regulations  and ordinances  made or promulgated by lawful  authority and now or
hereafter  applicable  to the  Mortgaged  Premises  within  such  time as may be
required by law.
<PAGE>
                8. The Mortgagor shall keep and maintain any buildings and other
structures on the Mortgaged Premises,  including fixtures and equipment, in good
and  substantial  repair,  and will make such  repairs as may be required by the
Mortgagee  within thirty (30) days from the written  notice from the  Mortgagee.
The Mortgagor  shall not do, and shall not permit to be done,  any act which may
in any way impair or weaken the security under this Mortgage,  and the Mortgagor
shall not remove or demolish or substantially  alter,  without the prior express
written consent of the Mortgagee, any building,  structure or improvement on the
Mortgaged Premises.

                9.  Mortgagor  shall have the right to prepay  this  Mortgage in
full or in part at any time.

                10. The Mortgagor shall pay any taxes, assessments, municipal or
governmental rates,  charges,  impositions,  liens, and water and sewer rents or
any part  thereof,  heretofore  or hereafter  imposed upon or which may become a
lien against the Mortgaged  Premises  within ten (10) days after the same is due
and payable and shall submit receipt therefore on request.

               11. The Mortgagor  hereby  presently  assigns all leases (present
and future),  rents,  issues,  and profits  arising out of or from the Mortgaged
Premises to the Mortgagee as additional security for payment of the indebtedness
secured  by this  mortgage  or under  the  Note,  and in the  event  of  default
hereunder  after notice the  Mortgagee  shall be entitled to enter upon and take
possession of the Mortgaged Premises,  and collect and receive all rents, issues
and profits arising from the Mortgaged Premises, including the rents, issues and
profits then due and unpaid to the Mortgagor  and also those  thereafter to fall
due.
               12.  The  Mortgagor  shall,  upon  the  written  request  of  the
Mortgagee, certify within ten (10) business days to such person as the Mortgagee
may  designate,  by  writing  duly  acknowledged,  the amount of  principal  and
interest then owing on this mortgage,  and whether any offsets or defenses exist
against the indebtedness evidenced by the Note.

               13. The Mortgagee may, at its option, expend money for insurance,
payment  of  taxes,  assessments,  municipal  or  governmental  rates,  charges,
impositions,  liens,  and  water  and sewer  rents or any part  thereof  and for
repair,  maintenance  and  preservation  of the  Mortgaged  Premises,  or of any
buildings or other structures thereon,  including fixtures, or for the discharge
of any liens or  encumbrances on the Mortgaged  Premises,  or for perfecting the
title thereto, or for enforcing  collection of the indebtedness  secured hereby,
or for any water,  gas or electric  charge imposed for any services  rendered to
the  Mortgaged  Premises,  or for  advances  of any  trustee or  receiver of the
Mortgaged  Premises,  or for  any  addition  or  improvements  to the  Mortgaged
Premises,  or to any buildings or other structures thereon,  including fixtures,
considered  desirable by the Mortgagee while it or any receiver or trustee is in
possession  thereof;  and all money so paid,  with interest at the rate fixed in
the Note,  shall be a lien on the Mortgaged  Premises added to the amount of the
Note and secured by this Mortgage and shall be due and payable upon demand.
<PAGE>
               14. No owner of the Mortgaged  Premises  shall be entitled to any
credit by reason of payment of any tax thereon.

               15. This Mortgage  constitutes a security agreement under the New
Jersey Uniform  Commercial Code and the Mortgagor hereby grants to the Mortgagee
a  security  interest  in  the  Mortgagor's  title  and  interest  in and to all
appurtenances,  fixtures,  equipment  and  improvements  to,  now  or  hereafter
installed,  placed or used in and  necessary  to the  operation  of building and
structure,   including  without  by  way  of  limitation,   lighting,   heating,
ventilating,  air-conditioning systems, sprinkling,  plumbing, gas, water, power
systems, boilers and meters, which are now, or which may hereafter be, placed or
located in, on, or upon the Mortgaged Premises herein defined, together with all
additions and accessories  thereto,  substitutions  therefor,  and  replacements
thereof and all cash and non-cash proceeds thereof. The Mortgagor shall execute,
deliver, file and refile any financing statements,  continuation statements,  or
other  security  agreements  that the Mortgagee may require from time to time to
confirm  the  lien of this  Mortgage  with  respect  to such  property.  Without
limiting the foregoing,  the Mortgagor hereby irrevocably appoints the Mortgagee
attorney-in-fact for the Mortgagor to execute, deliver and file such instruments
for and on behalf of the Mortgagor. Notwithstanding any release of any or all of
that property included in the Mortgaged Premises which is deemed "real property"
and proceedings to foreclose this Mortgage or its  satisfaction  of record,  the
terms hereof shall survive as a security  agreement with respect to the security
interest   created   hereby  and  referred  to  above  until  the  repayment  or
satisfaction in full of the obligations of the Mortgagor as are now or hereafter
secured hereby.

               16. The  proceeds of the Note shall be  disbursed  in  accordance
with the terms and conditions set forth in the Note.
<PAGE>
THE MORTGAGOR SHALL BE IN DEFAULT OF THIS MORTGAGE UPON THE OCCURRENCE OF ANY OF
THE FOLLOWING EVENTS:

               1. In the event that any  representation  or warranty made by the
Mortgagor  in  this  Mortgage,  in the  Note  or in any  other  writing  used in
connection herewith,  shall prove to be false,  incorrect,  or misleading in any
substantial and material respect as of the date when made.

               2. In the event that the Mortgagor  shall have failed to make any
payment of any  installment  due on the Note within the applicable  grace period
set forth  therein,  if any, or in the event of any default under the Note or in
any other writing used in connection therewith or herewith.

               3. In the event  that the  Mortgagor  shall  have  failed to duly
observe any  covenant,  condition  or  agreement  with respect to the payment of
monies on the part of  Mortgagor,  to be observed or  performed  pursuant to the
terms of the  Mortgage,  the Note or any other loan  document,  and such default
shall  have  remained  uncured  for a period of thirty  (30) days  after  notice
thereof to the Mortgagor by the Mortgagee.

               4. In the event the  Mortgagor  shall have failed to duly observe
or perform any covenant,  condition or agreement on the part of the Mortgagor to
be observed or performed pursuant to the terms of the Mortgage,  the Note or any
other loan document, other than the payment of monies which shall be governed by
paragraphs 2 and 3 above,  and such default  shall have  remained  uncured for a
period  of  thirty  (30) days  after  notice  thereof  to the  Mortgagor  by the
Mortgagee.

               5. In the event  that the  Mortgagor  shall have  applied  for or
consented to the appointment or a custodian, receiver, trustee, or liquidator of
all or substantial  part of its assets;  or shall generally be unable to pay its
debts when due; or shall have  admitted,  in writing,  its  inability to pay its
debts as they mature; or shall have made a general assignment for the benefit of
its creditors;  or shall have a petition or an answer seeking  reorganization or
an  arrangement  with  its  creditors  or  shall  have  taken  advantage  of any
insolvency  law,  or shall  have  submitted  an answer  admitting  the  material
allegations  of  a  petition  in  bankruptcy,   reorganization,   or  insolvency
proceedings;  or an order,  judgment or decree shall have been entered,  without
the application, approval or consent of the Mortgagor, by any Court of competent
jurisdiction  approving a petition seeking  reorganization of the Mortgagor,  or
appointing a custodian,  receiver,  trustee or liquidator of the Mortgagor, or a
substantial  part of its assets and such order,  judgment  or decree  shall have
continued  unstayed and in effect for any period of sixty (60) consecutive days;
or shall have  failed to remove an  involuntary  petition  in  bankruptcy  filed
against it within  sixty (60) days of the  filing  thereof;  or if any order for
Relief  shall have been  entered  under the Federal  Bankruptcy  Code of 1978 as
amended.
<PAGE>
               6. In the event of a subsequent  encumbrance  of or any change in
the  ownership of the  Mortgaged  Premises.


               7. In the  event  that  the   Mortgagor  shall  have  encumbered,
mortgaged  or given a security  interest  in any fixture or  fixtures,  or shall
have, without the consent of the Mortgagee, removed or replaced fixtures.

               8.  In the  event  that  default  is  made  in any of the  terms,
covenants and  conditions  contained in any other  mortgage  constituting a lien
upon the  Mortgaged  Premises,  or  should  proceedings  be  instituted  for the
foreclosure  or  collection  of  any  mortgage,   judgment,  or  lien  prior  or
subordinate to the lien of this Mortgage, affecting the Mortgaged Premises.

               9. In the  event  that any  insurance  company  authorized  to do
business in the State of New Jersey by the Department of Insurance, shall refuse
to  insure  said  Mortgaged  Premises  in the  form of  policy  approved  by the
Mortgagee,  so that there no longer exist  insurance  coverage in a sum equal to
the full insurable value of the Mortgaged Premises.

               10. In the event that the  Mortgagor  shall have entered into any
secondary  financing of the  Mortgaged  Premises or shall have  consented to the
placing of any lien on the Mortgaged Premises,  whether or not such financing or
lien is prior to or subordinate to the lien of the Mortgage.

               11. In the event that the  Mortgagor  shall have  transferred  or
caused to have been  transferred,  title to or possession of the interest in the
Mortgaged  Premises,  or any part hereof, to any party without the express prior
written consent of the Mortgagee.

               12.  In the  event  that  the  Mortgagor  shall  have  caused  or
permitted a security interest,  perfected or otherwise,  other than the security
interest  specifically  provided for or permit  hereunder,  to be created in any
collateral  provided  for  hereby,  or shall  have  failed  to take  any  action
requested by the Mortgagee to perfect or protect the security  interest provided
for herein.

               13. In the event of the  passage  of any law  deducting  from the
value of the land for the purposes of taxation, any lien thereon, or changing in
any way the  taxation of the  mortgages  or debts  secured  thereby for state or
local purposes.
<PAGE>
               SHOULD ANY DEFAULT BE MADE BY THE  MORTGAGOR,  THE  MORTGAGEE MAY
TAKE ANY OR ALL OF THE FOLLOWING ACTIONS, AT THE SAME OR AT DIFFERENT TIMES:

               1.  Declare the entire  amount of unpaid  principal,  accrued and
unpaid  interest  and other money due under this  Mortgage  and the Note secured
hereby, immediately due and payable.

               2. All rents,  issues and  profits  collected  or received by the
Mortgagor shall be accepted and held for the Mortgagee in trust and shall not be
co-mingled  with the funds and property of the  Mortgagor  but shall be promptly
paid  over  to the  Mortgagee.  The  Mortgagor  shall  pay to  the  Mortgagee  a
reasonable  rental for the Mortgaged  Premises  occupied by the Mortgagor on the
first day of each and every  month in  advance,  as a tenant from month to month
hereby  recognizing  the  Mortgagee  as  landlord;  and upon default in any such
payment,  the Mortgagor  shall vacate and surrender  possession of the Mortgaged
Premises to the Mortgagee or to any receiver, if one has been appointed,  and in
default  thereof,  the  Mortgagor  may  be  dispossessed  by the  usual  summary
proceedings.  The Mortgagor  agrees that this covenant shall be effective either
with or without any action being brought to foreclose this Mortgage, and with or
without the Mortgagee  having  applied for a receiver to collect the rents.  Any
such tenancy of the Mortgagor shall terminate at the option of the Mortgagee and
in any event,  upon the delivery of the Deed of any Sheriff or Master  following
foreclosure.
               3. The  Mortgagee  may  enter  upon and  take  possession  of the
Mortgaged  Premises and rent the same,  either in its name or in the name of the
owner of such property, and receive the rents, issues and profits,  thereof, and
apply the  same,  after the  payment  of the  necessary  charges  and  expenses,
including management  commissions,  on account of the debt secured hereby, being
accountable  only for such  rents and  profits as are  collected  by it while in
possession.
               4. The Mortgagee, at its option, may foreclose this Mortgage, and
upon the filing of a Complaint in  Foreclosure,  the Mortgagee shall be entitled
to the appointment of a receiver of the rents of the Mortgaged  Premises without
the necessity of proving either  inadequacy of the security or insolvency of the
Mortgagor or of any person who may be legally or  equitably  liable to pay money
secured  hereby,  and the  Mortgagor  and each such person  waive such proof and
consent to the appointment of such receiver.
<PAGE>
               5. In the event of a foreclosure sale of the Mortgaged  Premises,
the Mortgaged  Premises may, at the option of the  Mortgagee,  be sold in one or
several parcels.

               6. The Mortgagee may apply on account of the unpaid principal and
interest  thereon or on account of any  arrearages  of interest  thereon,  or on
account of any  balance due to the  Mortgagee  after a  foreclosure  sale of the
Mortgaged   Premises  whether  or  not  a  deficiency  action  shall  have  been
instituted, any unexpended monies still retained by the Mortgagee that were paid
by the  Mortgagor  to the  Mortgagee  for the payment of, or as security for the
payment  of  taxes,  assessments,  municipal  or  governmental  rates,  charges,
impositions,  liens, water or sewer rents, or insurance premiums,  if any, or in
order to secure the performance of some act by the Mortgagor.

                                  MISCELLANEOUS

               1. The rights and  remedies  herein  expressed to be vested in or
conferred upon the Mortgagee shall be cumulative and shall be in addition to and
not in substitution for or in derogation of the rights and remedies conferred by
any applicable  law. The failure,  at any one or more times, of the Mortgagee to
assert the right to declare the  principal  indebtedness  due or the granting of
any  extension or  extensions of time of payment of the Note either to the maker
thereof or to any other person,  or taking of other or  additional  security for
the payment thereof, or releasing any security,  or changing any of the terms of
the within Mortgage, or the Note or other obligation accompanying this mortgage,
or waiver of or failure to exercise any right under any covenant or  stipulation
herein contained shall not in any way affect this Mortgage nor the rights of the
Mortgagee  hereunder nor operate as a release from any personal  liability  upon
the Note or other obligation  accompanying this Mortgage, nor under any covenant
or stipulation  therein contained,  nor under any agreement assuming the payment
of said Note or obligation.

                2. All notices to be given hereunder shall be given by certified
mail directed to the Mortgagor or to the Mortgagee at the addresses shown at the
head of this Mortgage.

                3. All of the terms, covenants, provisions and conditions herein
contained shall be for the benefit of, apply to, and bind the heirs,  executors,
administrators,  successors, and assigns of the Mortgagor and the Mortgagee, and
are intended and shall be held to be real  covenants  running with the land, and
the term  "Mortgagor"  shall  also  include  any and all  subsequent  owners and
successors in title of the Mortgaged Premises.
<PAGE>
                4. All  references  herein to "Note"  shall be construed to mean
"Bond" or any other evidence of indebtedness secured hereby.

                5. when such  interpretation  is appropriate,  any word denoting
gender used herein shall include all persons,  natural or artificial,  and words
used in the singular shall include the plural.

                6. This Mortgage,  the loan made hereunder and the rights of the
parties  shall be governed by and  construed  under the laws of the State of New
Jersey.

                IN WITNESS WHEREOF, the Mortgagor has caused this Mortgage to be
duly executed as of the day and year first above written.


Attest:                                     Unigene Laboratories, Inc.




- -------------------------                   By ----------------------
Ronald S. Levy, Secretary                   Warren P. Levy, President
(Seal)
<PAGE>
STATE OF NEW JERSEY

                      )
                      ) ss:
COUNTY OF             )

               I certify that on    1999 Ronald S. Levy  personally  came before
me and this person acknowledged under oath, to my satisfaction, that:

              (a)  this person is the Secretary of Unigene  Laboratories,  Inc.,
                   the corporation named in this document;

              (b)  this person is the  attesting  witness to the signing of this
                   document by the proper corporate  officer who is Warren Levy,
                   the President of the corporation;

              (c)  this document was signed and delivered by the  corporation as
                   its voluntary act duly  authorized by a proper  resolution of
                   its Board of Directors;

              (d)  this person  knows the proper seal of the  corporation  which
                   was affixed to this document; and

              (e)  this person signed this proof to attest to the truth of these
                   facts.

                                                            --------------------
                                                            Ronald S. Levy
         Sworn and subscribed to before me
         this     day of             1999

         ----------------------------------

                                                                    Exhibit 10.5

                                  SECURED NOTE

$70,000.00                                                         July 30, 1999

         FOR VALUE RECEIVED,  the  undersigned,  Unigene  Laboratories,  Inc., a
Delaware corporation (the "Company"),  promises to pay to the order of Jay Levy,
or the holder hereof (the "Holder"),  on January 13, 2002 (the "Maturity Date"),
the principal sum of Seventy  Thousand  Dollars  ($70,000.00),  or, if less, the
unpaid principal  amount  outstanding at such time, in either case together with
all accrued and unpaid interest thereon.

         7. Security

                  The due and punctual payment by the Company of all amounts due
hereunder  is  secured  by that  certain  Mortgage,  dated  July  13,  1999  and
subsequently  amended,  issued by the Company to Jay Levy (the  "Mortgage")  and
that certain Amended and Restated  Security  Agreement,  dated July 13, 1999 and
subsequently  amended,  between the Company, Jay Levy, Warren P. Levy and Ronald
S. Levy (the "Security Agreement").

         8. Interest

         (a)      The  Company  promises  to pay to the Holder  interest  on the
unpaid  principal amount hereof from the date hereof at a rate of six percent (6
%) per year, compounded monthly.

         (b)      Interest  on this  Note  shall be  computed  on the basis of a
365-day year.

         9. Payments

         (a)      Commencing October 13, 1999, and on the 13th day of each month
thereafter through and including the Maturity Date, the Company shall pay to the
Holder the lesser of (i) $2,704.95  and (ii) the  outstanding  principal  amount
hereof plus all accrued and unpaid interest hereon.

         (b)      This Note may be prepaid by the Company,  in whole or in part,
at any time and from time to time without  premium or penalty.  All  prepayments
shall be credited first to accrued and unpaid interest and then to principal.

         (c)      All payments by the Company  hereunder  shall be made by check
not later than 5:00 p.m. Eastern time on the day when due.  Whenever any payment
to be made pursuant to this Note shall be stated to be due on a public  holiday,
Saturday or Sunday,  such  payment may be made on the next  succeeding  business
day.  Such  extension  of time shall not be  included in  computing  interest in
connection with such payment.
<PAGE>
10.      Events of Default

         (a)      An  "Event of  Default"  shall  exist if any of the  following
occurs and is continuing:

                  (i) the  Company  fails to make any  payment on this Note when
such  payment  is due and such  default  shall  continue  for more than ten (10)
business days;

                  (ii) the Company fails to comply with or breaches any material
provision of the Mortgage or the Security  Agreement  and such failure or breach
continues  for more than  thirty  (30) days after the  Holder has given  written
notice of such failure to the Company; or

                  (iii) a  receiver,  custodian,  liquidator  or  trustee of the
Company,  or of any of  the  property  of  the  Company  or any of its  material
subsidiaries, is appointed by court order; or the Company or any of its material
subsidiaries is adjudicated bankrupt or insolvent; or any of the property of the
Company or any of its material  subsidiaries is sequestered by court order; or a
petition to reorganize the Company or any of its material subsidiaries under any
bankruptcy, reorganization or insolvency law is filed against the Company or any
of its material  subsidiaries  and is not dismissed within sixty (60) days after
such  filing;  or  the  Company  or any of its  material  subsidiaries  files  a
voluntary bankruptcy petition or requesting  reorganization or arrangement under
any provision of any bankruptcy,  reorganization  or insolvency law, or consents
to the filing of any  petition  against it under any such law; or the Company or
any of its material  subsidiaries  makes a general assignment for the benefit of
its creditors,  or admits in writing its inability to pay its debts generally as
they  become  due, or  consents  to the  appointment  of a receiver,  trustee or
liquidator of the Company or any of its material  subsidiaries  or of all or any
part of the property of the Company or any of its material subsidiaries.

         (b)      If an Event of Default occurs under Section 4(a)(i), then this
Note shall accrue  additional  interest on all unpaid  amounts of principal  and
interest  from the date of the Event of Default at a rate equal to the lesser of
(i) eleven percent (11%) per annum or (ii) the highest amount allowable by law.

         (c)      If an Event of Default  exists,  then the Holder may  exercise
any right, power or remedy conferred upon it by law, and shall have the right to
declare by written notice the entire  principal and all interest accrued on this
Note to be, and such Note shall thereupon become,  forthwith due and payable and
the Company shall  immediately  pay to the Holder of this Note the entire unpaid
principal and interest accrued on this Note.

         (d)      In the case of an Event of Default, the Company, to the extent
permitted by law,  waives  presentment,  demand,  notice,  protest and all other
demands or notices in connection with the enforcement of this Note.

         11. Miscellaneous.

         (a)      No delay or omission by the Holder  hereof in  exercising  any
right or remedy hereunder shall constitute a waiver of any such right or remedy.
A waiver on one  occasion  shall not  operate  as a bar to or waiver of any such
right or remedy on any future occasion.
<PAGE>
         (b)      The Company  shall pay all  reasonable  costs and  expenses of
collection,  including attorney's fees, incurred or paid by the Holder hereof in
enforcing this Note and the obligations evidenced hereby.

         (c)      This Note may be  amended  only by  written  agreement  of the
Company and the Holder hereof.

         (d)      This Note  shall be  governed  by the laws of the State of New
Jersey without regard to its choice of law provisions.

         (e)      In the event that the Holder  notifies  the Company  that this
Note has been  mutilated,  lost,  stolen or destroyed,  the Company will issue a
replacement  Note  identical in all  respects to the  original  Note (except for
registration number and the then outstanding principal amount, if different than
that  shown on the  original  Note),  provided  that the Holder  surrenders  for
cancellation  its Note  certificate  in the case of a mutilated  certificate  or
provides  evidence  of  lost,  theft or  destruction  and  indemnity  reasonably
satisfactory  to  the  Company  in the  case  of a  lost,  stolen  or  destroyed
certificate .

         (f)      The Holder may mortgage,  encumber,  transfer or assign any of
its  rights or  interest  in and to this Note or any part  hereof  and,  without
limitation,  each  assignee,  transferee  and  mortgagee  (which may include any
affiliate of the Holder) shall have the right to so mortgage, encumber, transfer
or assign its  interest.  The Company may not assign its  obligations  hereunder
without the prior written  consent of the Holder,  except that without the prior
written  consent of the Holder,  but after  notice  duly given,  the Company may
assign its obligations hereunder to any successor-in-interest corporation in the
event  of a  merger  or  consolidation  of the  Company  with  or  into  another
corporation,  or the sale of all or substantially  all of the Company's  assets.
The Note shall in all cases be binding on the  Company  and its  successors  and
assigns and inure to the benefit of the Holder and its successors and assigns.

         IN WITNESS WHEREOF, the Company has caused this Note to be executed and
delivered as of the day and year first written above.

                                                     UNIGENE LABORATORIES, INC.

                                                     By:
                                                       -------------------------

                                                     Title:
                                                           ---------------------

[Corporate Seal]

                                                                    Exhibit 10.6
                                  SECURED NOTE

$200,000.00                                                       August 5, 1999

         FOR VALUE RECEIVED,  the  undersigned,  Unigene  Laboratories,  Inc., a
Delaware corporation (the "Company"),  promises to pay to the order of Jay Levy,
or the holder hereof (the "Holder"),  on January 13, 2002 (the "Maturity Date"),
the principal sum of Two Hundred  Thousand Dollars  ($200,000.00),  or, if less,
the unpaid  principal  amount  outstanding at such time, in either case together
with all accrued and unpaid interest thereon.

         12. Security

                  The due and punctual payment by the Company of all amounts due
hereunder  is  secured  by that  certain  Mortgage,  dated  July  13,  1999  and
subsequently  amended,  issued by the Company to Jay Levy (the  "Mortgage")  and
that certain Amended and Restated  Security  Agreement,  dated July 13, 1999 and
subsequently  amended,  between the Company, Jay Levy, Warren P. Levy and Ronald
S. Levy (the "Security Agreement").

         13. Interest

         (a)      The  Company  promises  to pay to the Holder  interest  on the
unpaid  principal amount hereof from the date hereof at a rate of six percent (6
%) per year, compounded monthly.

         (b)      Interest  on this  Note  shall be  computed  on the basis of a
365-day year.

         14. Payments

         (a)      Commencing October 13, 1999, and on the 13th day of each month
thereafter through and including the Maturity Date, the Company shall pay to the
Holder the lesser of (i) $7,720.84  and (ii) the  outstanding  principal  amount
hereof plus all accrued and unpaid interest hereon.

         (b)      This Note may be prepaid by the Company,  in whole or in part,
at any time and from time to time without  premium or penalty.  All  prepayments
shall be credited first to accrued and unpaid interest and then to principal.

         (c)      All payments by the Company  hereunder  shall be made by check
not later than 5:00 p.m. Eastern time on the day when due.  Whenever any payment
to be made pursuant to this Note shall be stated to be due on a public  holiday,
Saturday or Sunday,  such  payment may be made on the next  succeeding  business
day.  Such  extension  of time shall not be  included in  computing  interest in
connection with such payment.
<PAGE>
15. Events of Default

(a)      An "Event of Default" shall exist if any of the following occurs and is
continuing:

                  (i) the  Company  fails to make any  payment on this Note when
such  payment  is due and such  default  shall  continue  for more than ten (10)
business days;

                  (ii) the Company fails to comply with or breaches any material
provision of the Mortgage or the Security  Agreement  and such failure or breach
continues  for more than  thirty  (30) days after the  Holder has given  written
notice of such failure to the Company; or

                  (iii) a  receiver,  custodian,  liquidator  or  trustee of the
Company,  or of any of  the  property  of  the  Company  or any of its  material
subsidiaries, is appointed by court order; or the Company or any of its material
subsidiaries is adjudicated bankrupt or insolvent; or any of the property of the
Company or any of its material  subsidiaries is sequestered by court order; or a
petition to reorganize the Company or any of its material subsidiaries under any
bankruptcy, reorganization or insolvency law is filed against the Company or any
of its material  subsidiaries  and is not dismissed within sixty (60) days after
such  filing;  or  the  Company  or any of its  material  subsidiaries  files  a
voluntary bankruptcy petition or requesting  reorganization or arrangement under
any provision of any bankruptcy,  reorganization  or insolvency law, or consents
to the filing of any  petition  against it under any such law; or the Company or
any of its material  subsidiaries  makes a general assignment for the benefit of
its creditors,  or admits in writing its inability to pay its debts generally as
they  become  due, or  consents  to the  appointment  of a receiver,  trustee or
liquidator of the Company or any of its material  subsidiaries  or of all or any
part of the property of the Company or any of its material subsidiaries.

         (b)      If an Event of Default occurs under Section 4(a)(i), then this
Note shall accrue  additional  interest on all unpaid  amounts of principal  and
interest  from the date of the Event of Default at a rate equal to the lesser of
(i) eleven percent (11%) per annum or (ii) the highest amount allowable by law.

         (c)      If an Event of Default  exists,  then the Holder may  exercise
any right, power or remedy conferred upon it by law, and shall have the right to
declare by written notice the entire  principal and all interest accrued on this
Note to be, and such Note shall thereupon become,  forthwith due and payable and
the Company shall  immediately  pay to the Holder of this Note the entire unpaid
principal and interest accrued on this Note.

         (d)      In the case of an Event of Default, the Company, to the extent
permitted by law,  waives  presentment,  demand,  notice,  protest and all other
demands or notices in connection with the enforcement of this Note.

         16. Miscellaneous.

         (a)      No delay or omission by the Holder  hereof in  exercising  any
right or remedy hereunder shall constitute a waiver of any such right or remedy.
A waiver on one  occasion  shall not  operate  as a bar to or waiver of any such
right or remedy on any future occasion.
<PAGE>
         (b)      The Company  shall pay all  reasonable  costs and  expenses of
collection,  including attorney's fees, incurred or paid by the Holder hereof in
enforcing this Note and the obligations evidenced hereby.

         (c)      This Note may be  amended  only by  written  agreement  of the
Company and the Holder hereof.

         (d)      This Note  shall be  governed  by the laws of the State of New
Jersey without regard to its choice of law provisions.

         (e)      In the event that the Holder  notifies  the Company  that this
Note has been  mutilated,  lost,  stolen or destroyed,  the Company will issue a
replacement  Note  identical in all  respects to the  original  Note (except for
registration number and the then outstanding principal amount, if different than
that  shown on the  original  Note),  provided  that the Holder  surrenders  for
cancellation  its Note  certificate  in the case of a mutilated  certificate  or
provides  evidence  of  lost,  theft or  destruction  and  indemnity  reasonably
satisfactory  to  the  Company  in the  case  of a  lost,  stolen  or  destroyed
certificate .

         (f)      The Holder may mortgage,  encumber,  transfer or assign any of
its  rights or  interest  in and to this Note or any part  hereof  and,  without
limitation,  each  assignee,  transferee  and  mortgagee  (which may include any
affiliate of the Holder) shall have the right to so mortgage, encumber, transfer
or assign its  interest.  The Company may not assign its  obligations  hereunder
without the prior written  consent of the Holder,  except that without the prior
written  consent of the Holder,  but after  notice  duly given,  the Company may
assign its obligations hereunder to any successor-in-interest corporation in the
event  of a  merger  or  consolidation  of the  Company  with  or  into  another
corporation,  or the sale of all or substantially  all of the Company's  assets.
The Note shall in all cases be binding on the  Company  and its  successors  and
assigns and inure to the benefit of the Holder and its successors and assigns.

         IN WITNESS WHEREOF, the Company has caused this Note to be executed and
delivered as of the day and year first written above.

                                                    UNIGENE LABORATORIES, INC.

                                                     By:
                                                       -------------------------

                                                     Title:
                                                          ----------------------
[Corporate Seal]

                                                                    Exhibit 10.7

                                                         Prepared by:

                                                         -----------------------
                                                         T. Thomas Van Dam, Esq.

                   MODIFICATION OF MORTGAGE AND SECURITY AGREEMENT

               This   modification   of   Mortgage    and   Security   Agreement
("Modification")  made  effective  as of the 5th  day of  August,  1999,  by and
between  UNIGENE  LABORATORIES,  INC., a Delaware  corporation  authorized to do
business in New Jersey, having  office at 110 Little Falls Road, Fairfield,  New
Jersey  07004 (the  "Mortgagor")  and JAY LEVY,  with an address at 2150  Center
Avenue, Fort Lee, New Jersey 07024 (the "Mortgagee").

               WHEREAS,  on July  13,  1999  the  Mortgagee  provided  a loan to
Mortgagor in the principal amount of ONE MILLION SIX HUNDRED THOUSAND and 00/100
($1,600,000.00)  DOLLARS  (the  "Loan") as  evidenced  by a certain  Amended and
Restated Secured Note dated July 13, 1999 (the "Note"); and

               WHEREAS,  in connection with the Loan the Mortgagor  executed and
delivered a Mortgage and Security Agreement to the Mortgagee dated July 13, 1999
which has been  forwarded to the Essex County  Register's  office for  recording
(the "Mortgage"), with respect to property located in the Township of Fairfield,
County  of Essex  and  State of New  Jersey  as  particularly  described  in the
Mortgage (the "Premises"); and

               WHEREAS,   Mortgagee  provided   additional  loans  to  Mortgagor
evidenced  by a Secured  Note  dated  July 30,  1999 in the  amount  of  SEVENTY
THOUSAND and 00/100 ($70,000.00) DOLLARS and a Secured Note dated August 5, 1999
in the amount of TWO HUNDRED THOUSAND and 00/100  ($200,000.00)  DOLLARS made by
Mortgagor to Mortgagee (the "Additional Loans").

               WHEREAS,  as a  condition  of  the  Additional  Loans,  Mortgagee
required  that the  Mortgagor  amend the  Mortgage to secure the  Secured  Notes
evidencing the Additional Loans.

               NOW, THEREFORE, the parties agree as follows:

               1.  Modification  of  Mortgage.  The  Mortgage  shall  be  deemed
modified to secure the  Additional  Loans as evidenced by the Secured Note dated
July 30, 1999 in the amount of Seventy Thousand and 00/100 ($70,000.00)  Dollars
and  the  Secured  Note  in  the  amount  of Two  Hundred  Thousand  and  00/100
($200,000.00) Dollars dated August 5, 1999, and accordingly the total amount due
Mortgagee by Mortgagor  and secured by the Mortgage as hereby  amended  shall be
the  amount  of  One  Million   Eight  Hundred   Seventy   Thousand  and  00/100
($1,870,000.00) Dollars.
<PAGE>
               2. Mortgagor's Estoppel. Mortgagor does hereby represent, warrant
and confirm  that there are no set-offs,  rights,  claims or causes of action of
any nature  whatsoever which Mortgagor has or may assert against  Mortgagee with
respect to the  Mortgage  as amended  and the  indebtedness  secured  thereby as
aforesaid.

               3.  Affirmation  of Validity of Loan  Documents.  Mortgagor  does
hereby affirm the extent and validity of the Mortgage, as amended, and the Notes
secured  thereby,   and  does  confirm  that  all  loan  documentation   remains
enforceable,  and in full force and effect as of the date of  execution  hereof,
and that the Mortgage,  as modified by the within Agreement,  shall constitute a
continuing,  valid lien upon the Mortgaged  Premises,  to secure  payment of the
indebtedness evidenced by the Notes as aforesaid.

               4. Binding Effect. The within Agreement shall be binding upon the
parties hereto, their successors and assigns.

               5.  Governing  Law. The within  Agreement  shall be construed and
enforced in accordance with the laws of the State of New Jersey.

               6.  Copy  Acknowledge.  The  undersigned  Mortgagor  acknowledges
receipt of a true copy of this document without charge.
<PAGE>
               IN  WITNESS  WHEREOF,  the  parties  hereto  have  executed  this
Modification  of Mortgage  and  Security  Agreement as of the day and year first
above written.

Attest:                                            Unigene Laboratories, Inc.

                                                   By
                                                     ---------------------------
Ronald S. Levy, Secretary                          Warren P. Levy, President


Witness:

<PAGE>

STATE OF NEW JERSEY )
                    )ss:
COUNTY OF ESSEX     )

               I certify  that on August  , 1999 Ronald S. Levy personally  came
before me and this person acknowledged under oath, to my satisfaction, that:

               (a)  this person is the Secretary of Unigene Laboratories,  Inc.,
                    the corporation named in this document;

               (b)  this person is the attesting  witness to the signing of this
                    document by the proper corporate officer who is Warren Levy,
                    the President of the corporation;

               (c)  this document was signed and delivered by the corporation as
                    its voluntary act duly authorized by a proper  resolution of
                    its Board of Directors;

               (d)  this person knows the proper seal of the  corporation  which
                    was affixed to this document; and

               (e)  this  person  signed  this  proof to  attest to the truth of
                    these facts.


                                                    ----------------------------
                                                    Ronald S. Levy

Sworn and Subscribed to this
  day of August, 1999

- ----------------------------

                                                                    Exhibit 10.8

                         AMENDMENT TO SECURITY AGREEMENT
                           AND SUBORDINATION AGREEMENT

         THIS AMENDMENT TO SECURITY  AGREEMENT AND SUBORDINATION  AGREEMENT (the
"Amendment")  is entered into this 5th day of August,  1999 by and among UNIGENE
LABORATORIES,  INC.,  a  Delaware  corporation,  having its  principal  place of
business at 110 Little Falls Road, Fairfield,  New Jersey 07004 (the "Company"),
Jay Levy,  a resident of New Jersey,  Warren P. Levy,  a resident of New Jersey,
and  Ronald S. Levy,  a resident  of New  Jersey.  Jay Levy,  Warren P. Levy and
Ronald S. Levy are sometimes  individually  referred to as a "Secured Party" and
collectively referred to as "Secured Parties."

                                   WITNESSETH:

         WHEREAS,  the parties  hereto are parties to that  certain  Amended and
Restated  Security  Agreement,  dated July 13, 1999 (the "Security  Agreement"),
pursuant to which the Company granted the Secured Parties a security interest in
the Collateral (as defined in the Security Agreement) in order to secure payment
of certain loans made by the Secured Parties; and

         WHEREAS,  the parties hereto are parties to that certain  Subordination
Agreement,  dated July 13,  1999 (the  "Subordination  Agreement"),  pursuant to
which Warren P. Levy and Ronald S. Levy subordinated their security interests in
the Collateral to the security interest in the Collateral held by Jay Levy; and

         WHEREAS,  on July 30,  1999,  Jay Levy loaned the Company  $70,000,  as
evidenced by a secured  promissory  note dated as of July 30, 1999 (the "July 30
Note") and on the date hereof Jay Levy loaned the Company $200,000, as evidenced
by a secured promissory note dated the date hereof (the "August 5 Note"); and

         WHEREAS,  the parties  hereto  desire that the  Security  Agreement  be
amended on the terms set forth herein to include the July 30 Note and the August
5 Note in the definition of "Obligations;" and

         WHEREAS, the parties hereto desire that the Subordination  Agreement be
amended on the terms set forth herein to include the July 30 Note and the August
5 Note in the definition of "Senior Debt."

         NOW, THEREFORE,  for good and valuable  consideration,  the receipt and
sufficiency  of  which is  hereby  acknowledged,  the  parties  hereto  agree as
follows:
<PAGE>
         1. The definition of the term "Obligations" set forth in Section 1.3 of
the  Security   Agreement  is  hereby  amended  to  include  all   indebtedness,
obligations and liabilities of the Company under the July 30 Note and the August
5 Note.

         2. The definition of the term "Senior Debt" set forth in Section 1.2(a)
of the  Subordination  Agreement is hereby amended to include all  indebtedness,
obligations  and  liabilities  of the Company to Jay Levy under the July 30 Note
and the August 5 Note.

         3. This Amendment shall be construed in accordance with and governed by
the laws of the State of New Jersey  without  giving effect to conflicts of laws
principles.

         4. This Amendment may be executed in two or more counterparts,  each of
which shall  constitute an original and all of which shall  constitute  the same
instrument.

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Amendment to be executed on the day and year first above written.

                                            UNIGENE LABORATORIES, INC.

                                            By:
                                                     Name:
                                                     Title:

                                            ------------------------------------
                                            JAY LEVY


                                            ------------------------------------
                                            WARREN P. LEVY


                                            ------------------------------------
                                            RONALD S. LEVY

<TABLE> <S> <C>

<ARTICLE> 5

<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-1999
<PERIOD-END>                               SEP-30-1999
<CASH>                                         668,379
<SECURITIES>                                         0
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                    699,628
<CURRENT-ASSETS>                             3,439,040
<PP&E>                                      17,482,087
<DEPRECIATION>                              10,451,564
<TOTAL-ASSETS>                              14,210,596
<CURRENT-LIABILITIES>                        4,530,073
<BONDS>                                      3,987,006
                                0
                                          0
<COMMON>                                       411,816
<OTHER-SE>                                   5,281,701
<TOTAL-LIABILITY-AND-EQUITY>                14,210,596
<SALES>                                              0
<TOTAL-REVENUES>                             9,527,575
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                             8,915,487
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             489,709
<INCOME-PRETAX>                                151,229
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            151,229
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   151,229
<EPS-BASIC>                                          0
<EPS-DILUTED>                                        0


</TABLE>


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