UNIGENE LABORATORIES INC
S-8, EX-5, 2000-12-21
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                                                   EXHIBIT 5

                              COVINGTON & BURLING
                         1201 Pennsylvania Avenue, N.W.
                             Washington, D.C. 20044
                                 (202) 662-6000

                                                                BRUSSELS
    LECONFIELD HOUSE                ---                   CORRESPONDENT OFFICE
     CURZON STREET         TELEAX: (202) 662-6291         44 AVENUE DES ARTS
     LONDON WIY BAS     TELEX: 89-593 (COVLING WSH)      BRUSSELS 1040 BELGIUM
        ENGLAND                CABLE: COVLING          TELEPHONE: 32-2-512-9890
TELEPHONE: 071-495-5655             ---                 TELEFAX: 32-2-502-1598
 TELEFAX: 071-495-3101   WRITER'S DIRECT DIAL NUMBER


                                                              December 21, 2000


Unigene Laboratories, Inc.
110 Little Falls Road
Fairfield, NJ 07004


         Re:  Unigene Laboratories, Inc.
              Form S-8 Registration Statement


Gentlemen:


         This  opinion  is  being   furnished  to  you  in  connection   with  a
Registration  Statement on Form S-8 (the "Registration  Statement") filed on the
date  hereof  by  Unigene  Laboratories,   Inc.,  a  Delaware  corporation  (the
"Company"), with the Securities and Exchange Commission (the "Commission") under
the Securities Act of 1933, as amended, for the registration of 1,000,000 shares
of common stock,  par value $.01 per share, of the Company (the "Common Stock").
The shares of Common Stock being  registered  are issuable  upon the exercise of
stock options granted under the Company's 2000 Stock Option Plan (the "Plan").

         For purposes of this  opinion,  we have  examined  signed copies of the
Registration  Statement  and the  exhibits  thereto.  We also have  examined and
relied upon a copy of the Company's  Certificate of Incorporation,  certified by
the  Secretary  of State of the State of Delaware,  and copies of the  Company's
Bylaws and certain resolutions adopted by the Board of Directors of the Company,
certified  by the  Secretary of the Company.  We also have  examined  such other
documents and made such other investigations as we have deemed necessary to form
a basis for the opinion hereinafter expressed.

         In examining the foregoing documents,  we have assumed the authenticity
of documents  submitted to us as originals,  the  genuineness of all signatures,
the conformity to original documents of documents submitted to us as copies, and
the accuracy of the representations and statements included therein.


<PAGE>


Unigene Laboratories, Inc.
December 21, 2000
Page 2


         Based on the foregoing, we are of the opinion that the shares of Common
Stock being registered by the  Registration  Statement have been duly authorized
and,  when  issued and sold by the Company in  accordance  with the terms of the
Plan and the terms of the stock  options  granted  thereunder,  will be  validly
issued, fully paid and nonassessable.

         We hereby  consent to the  filing of this  opinion as an exhibit to the
Registration Statement and to the use of our name in the Registration Statement.

                                                     Very truly yours,

                                                     /s/  COVINGTON & BURLING

                                                     COVINGTON & BURLING





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