UNIGENE LABORATORIES INC
DEF 14A, 2000-04-28
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934

[ X ] Filed by the registrant

[   ] Filed by a party other than the registrant


Check the appropriate box:

[   ] Preliminary Proxy Statement

[   ] Confidential, for Use of the Commission Only
      (as permitted by Rule 14a-6(e)(2))

[ X ] Definitive Proxy Statement

[   ] Definitive Additional Materials

[   ] Soliciting Material Pursuant to ss. 240.14a-11(c) or ss. 240.14a-12


                           Unigene Laboratories, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

Payment of Filing Fee (Check the appropriate box):
[X]      No fee required.
[ ]      Fee computed on table below per Exchange Act Rules 14a-6(i)(4)and 0-11.

         1)    Title of each class of securities to which  transaction  applies:
               N/A

         2)    Aggregate number of securities to which transaction applies: N/A

         3)    Per unit price or other underlying value of transaction  computed
               pursuant  to  Exchange  Act Rule  0-11.  (Set forth the amount on
               which  the  filing  fee  is  calculated  and  state  how  it  was
               determined): N/A

         4)    Proposed maximum aggregate value of transaction: N/A

         5)    Total fee paid: N/A

[ ]      Fee paid previously with preliminary materials.

[ ]      Check box if any part of the fee is offset as provided by Exchange Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the Form or Schedule and the date of its filing.

         1)    Amount Previously Paid:  N/A
         2)    Form, Schedule or Registration Statement No.: N/A
         3)    Filing Party:  N/A
         4)    Date Filed:  N/A

<PAGE>


                                 [UNIGENE LOGO]
                           Unigene Laboratories, Inc.
                             110 Little Falls Road
                          Fairfield, New Jersey 07004
                                 (973) 882-0860


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           To be held on June 6, 2000

     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders  of Unigene
Laboratories,  Inc., a Delaware corporation (the "Company"), will be held at The
Days Inn of Parsippany,  3159 U.S. Highway 46 East, Parsippany, New Jersey 07054
on June 6,  2000,  at 11:00  A.M.,  Eastern  Daylight  Time,  for the  following
purposes:

1.       To elect directors of the Company;
2.       To approve the adoption of the Company's 2000 Stock Option Plan;
3.       To ratify the appointment of KPMG LLP as auditors of the Company; and
4.       To transact such other business as may properly come before the meeting
         and any adjournment thereof.

     The Board of  Directors  has fixed the close of business on April 13, 2000,
as the record date for the  determination  of  stockholders  who are entitled to
notice of and to vote at the meeting.
     A copy of the Company's  Annual Report for the year ended December 31, 1999
is sent to you along with the Proxy Statement.
     To assure your representation at the meeting,  please sign, date and return
your proxy in the enclosed envelope,  which requires no postage if mailed in the
United States.

                                              By Order of the Board of Directors



                                              RONALD S. LEVY
                                              Secretary

April 28,2000
<PAGE>

                                 [UNIGENE LOGO]
                           Unigene Laboratories, Inc.
                             110 Little Falls Road
                          Fairfield, New Jersey 07004
                                 (973) 882-0860

                                PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS

     This Proxy  Statement is furnished in connection  with the  solicitation of
proxies by the Board of  Directors  of Unigene  Laboratories,  Inc.,  a Delaware
corporation  (the  "Company"),  for the Annual  Meeting of  Stockholders  of the
Company  to be held at The Days Inn of  Parsippany,  3159 U.S.  Highway 46 East,
Parsippany,  New Jersey 07054 on June 6, 2000, at 11:00 A.M.,  Eastern  Daylight
Time.

     You are requested to complete, date and sign the accompanying form of proxy
and return it to the Company in the enclosed envelope.  The proxy may be revoked
at any time before it is  exercised by written  notice to the Company  bearing a
later date than the date on the proxy,  provided  such notice is received by the
Company prior to the start of the meeting. Any stockholder attending the meeting
may vote in person  whether or not he or she has  previously  submitted a proxy.
Where  instructions  are  indicated,  a duly  executed  proxy  will be  voted in
accordance with such instructions.  Where no instructions are indicated,  a duly
executed proxy will be voted for each of the director  nominees named herein and
in favor of each of the proposals set forth in the attached Notice.

     The Board of  Directors  has fixed the close of business on April 13, 2000,
as the record date (the "Record Date") for the determination of stockholders who
are entitled to notice of and to vote at the meeting. As of the Record Date, the
outstanding  shares of the Company  entitled to vote were  43,968,212  shares of
common stock,  par value $.01 per share ("Common  Stock"),  the holders of which
are entitled to one vote per share.

     The  holders  of a  majority  of the  outstanding  shares of Common  Stock,
present in person or  represented  by proxy,  will  constitute  a quorum for the
conduct  of  business  at the  Annual  Meeting.  Directors  will be elected by a
plurality of the votes cast. The  affirmative  vote of the holders of a majority
of the shares present and entitled to vote at the Annual Meeting is required for
the approval of the adoption of the Company's 2000 Stock Option Plan and for the
ratification  of the  appointment  of KPMG LLP as auditors of the  Company.  For
matters  that require for  adoption  the  affirmative  vote of a majority of the
shares of Common Stock present and entitled to vote,  abstentions are considered
as shares present and entitled to vote and,  therefore,  have the effect of a no
vote, whereas broker non-votes are considered shares not present and entitled to
vote and, therefore, have no impact on the outcome of the vote.

     This  Proxy  Statement  and the  accompanying  Notice of Annual  Meeting of
Stockholders  and form of proxy are being mailed to the stockholders on or about
April  28,  2000.  A copy of the  Company's  Annual  Report  for the year  ended
December 31,1999, is also enclosed.

SECURITY OWNERSHIP OF MANAGEMENT

     The following table sets forth information as of April 13, 2000, concerning
the beneficial  ownership of Common Stock by each director of the Company,  each
executive officer of the Company listed in the Summary  Compensation  Table, and
all directors and executive officers of the Company as a group.

               Name of             Amount and Nature of       Percent of
               Beneficial Owner    Beneficial Ownership (1)   Class
               ----------------    ------------------------   -----------
               Warren P. Levy             1,980,545 (2)             4.5%
               Ronald S. Levy             1,995,545 (2)             4.5%
               Jay Levy                     563,095 (3)             1.3%
               James P. Gilligan            307,660 (4)             0.7%
               Robert F. Hendrickson         55,000 (5)             0.1%
               Allen Bloom                   31,000 (6)             0.1%
               Officers and Directors
                 as a Group (6 persons)   4,732,845 (2)(7)         10.7%

                                       1
<PAGE>

- -------------------------
(1) Unless otherwise noted, each person or group member has reported sole voting
    and sole dispositive  power with respect to securities shown as beneficially
    owned by him.
(2) Includes 200,000 shares of Common Stock held in a family trust over on which
    Warren P. Levy and Ronald S. Levy in their capacity as trustees share voting
    and dispositive power.
(3) Includes  40,000  shares  of  Common  Stock  that Mr.  Levy has the right to
    acquire pursuant to stock options that are exercisable either immediately or
    within 60 days.
(4) Includes  288,000 shares of Common Stock that Dr.  Gilligan has the right to
    acquire pursuant to stock options that are exercisable either immediately or
    within 60 days.
(5) Includes 40,000 shares of Common Stock that Mr. Hendrickson has the right to
    acquire pursuant to stock options that are exercisable either immediately or
    within 60 days.
(6) Includes  30,000  shares of  Common  Stock  that Dr.  Bloom has the right to
    acquire pursuant to stock options that are exercisable either immediately or
    within 60 days.
(7) Includes an  aggregate  of 398,000  shares of Common Stock that such persons
    have the right to acquire  pursuant to stock  options  that are  exercisable
    either immediately or within 60 days.

                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

Five  directors  of the  Company  are to be elected at the Annual  Meeting.  The
directors will be elected to serve until the Annual Meeting of  Stockholders  to
be held in 2001, and until their  respective  successors shall have been elected
and  qualified.

Each of the nominees is currently a director of the Company and was elected as a
director at the Company's  Annual Meeting of  Stockholders in 1999. The Board of
Directors  has no reason to believe  that any of the nominees are or will become
unavailable  for  election  as a  director.  However,  should any of them become
unwilling  or  unable  to  serve as a  director,  the  individuals  named in the
enclosed  proxy will vote for the election of a substitute  nominee  selected by
the  Board of  Directors  or,  if no such  person  is  nominated,  the  Board of
Directors will reduce the number of Directors to be elected.

The  following  table sets forth  certain  information  with respect to the five
nominees.
                                                        Served
                                                     Continuously
Name                             Age              as Director Since
- ----                             ---              -----------------
Warren P. Levy (1)               48                      1980
Ronald S. Levy (1)               51                      1980
Jay Levy (1)                     76                      1980
Allen Bloom                      56                      1998
Robert F. Hendrickson            67                      1997

- -------------------------
(1) Dr.  Warren P. Levy and Dr.  Ronald S. Levy are brothers and are the sons of
    Mr. Jay Levy.

     Dr.  Warren P. Levy,  a founder of the  Company,  has served as  President,
Chief  Executive  Officer and  Director of the Company  since its  formation  in
November 1980. Dr. Levy holds a Ph.D. in biochemistry and molecular biology from
Northwestern   University  and  a  bachelor's   degree  in  chemistry  from  the
Massachusetts Institute of Technology.

     Dr. Ronald S. Levy, a founder of the Company, has served as Director of the
Company since its formation in November 1980, as Executive Vice President  since
April 1999 and as Secretary  since May 1986.  From  November  1980 through March
1999,  he served as Vice  President  of the Company.  Dr. Levy holds a Ph.D.  in
bioinorganic  chemistry  from  Pennsylvania  State  University  and a bachelor's
degree in chemistry from Rutgers University.

     Mr. Jay Levy, a founder of the Company, has served as Chairman of the Board
of Directors and Treasurer of the Company since its formation in November  1980.
Mr. Levy is a part-time employee of the Company and devotes approximately 15% of
his time to the  Company.  From 1985  through  February  1991,  he served as the
principal  financial  advisor to the Estate of Nathan Cummings and its principal
beneficiary,   The  Nathan  Cummings   Foundation,   Inc.,  a  large  charitable
foundation. For the seventeen years prior thereto, he performed similar services
for the late Nathan Cummings, a noted industrialist and philanthropist.

     Dr. Allen Bloom, a patent  attorney,  has been a partner in Dechert Price &
Rhoads,  a law firm, for the past six years where he  established  and heads the
patent  practice  group  which  focuses on  biotechnology,  pharmaceuticals  and
medical  devices.  For the nine  years  prior  thereto,  he was Vice  President,
General  Counsel and Secretary of The Liposome  Company,  Inc., a  biotechnology
company.  His responsibilities  there included patent,  regulatory and licensing
activities.  Dr.  Bloom  holds a Ph.D.  in  organic  chemistry  from Iowa  State
University.

                                       2
<PAGE>

     Mr. Robert F.  Hendrickson  was Senior Vice  President,  Manufacturing  and
Technology, for Merck & Co., Inc., an international pharmaceutical company, from
1985 to 1990. Since 1990, Mr. Hendrickson has been a management  consultant with
a number of biotechnology and pharmaceutical  companies among his clients. He is
currently a director of Envirogen, Inc. an environmental  biotechnology company,
and of Cytogen, Inc. and The Liposome Co., Inc., both of which are biotechnology
companies.

BOARD OF DIRECTORS AND COMMITTEES

     During 1999, there were five meetings of the Board of Directors.

     Several  important  functions of the Board of Directors may be performed by
committees  that  are  comprised  of  members  of the  Board of  Directors.  The
Company's  By-laws  authorize  the formation of these  committees  and grant the
Board the  authority  to  prescribe  the  functions  of each  committee  and the
standards  for  membership  of each  committee.  The  Board  has  four  standing
committees:  an  Audit  Committee,  a  Compensation  Committee,  a Stock  Option
Committee for the employee  stock option plans and a Stock Option  Committee for
the directors stock option plan. The Board of Directors does not have a standing
nominating  committee.

     The  responsibilities  of the  Audit  Committee  include  (i)  annually  to
recommend a firm of independent  public accountants to the Board of Directors to
act as auditors of the  Company;  (ii) review the scope of the annual audit with
the auditors in advance of the audit,  (iii) review the results of the audit and
the adequacy of the Company's accounting, financial and operating controls; (iv)
review  the  Company's  accounting  and  reporting   principles,   policies  and
practices; and (v) approval of fees paid to the auditors for audit and non-audit
services. The current members of the Audit Committee are Messrs. Jay Levy, Allen
Bloom and Robert Hendrickson. The Audit Committee held one meeting during 1999.

     The  responsibilities of the Compensation  Committee include (i) review and
approval of the compensation  (including  salaries and bonuses) of the Company's
officers; (ii) overseeing the administration of the Company's 401(k) Plan; (iii)
review and  approve  general  benefits  and  compensation  strategies;  and (iv)
approval of the  Compensation  Committee  report included in the Company's proxy
statement. The current members of the Compensation Committee are Messrs. Jay
Levy, Allen Bloom and Robert  Hendrickson.  The Compensation  Committee held one
meeting during 1999.

     Subject  to the  limitations  set  forth in the  plans,  the  Stock  Option
Committee  for the employee  stock option plans (i) selects the  employees to be
granted  options;  (ii) fixes the number of shares to be covered by the  options
granted;  and (iii) determines the exercise price and other terms and conditions
of each option.  The current members of the Committee are Allen Bloom and Robert
Hendrickson.  The Committee  did not meet during 1999 but  approved,  by written
consent, 12 stock option grants to 71 employees.

     Subject  to the  limitations  set  forth  in the  plan,  the  Stock  Option
Committee for the directors  stock option plan interprets the plan and makes all
determinations  necessary for the plan's administration.  The current members of
the Committee are Jay Levy,  Warren Levy and Ronald Levy. There were no meetings
held by this committee during 1999.

     Directors  who are not  employees  receive an annual  retainer of $8,000 as
well  as a fee of  $1,000  for  each  Board  meeting  attended.  Mr.  Robert  F.
Hendrickson  and Dr. Allen Bloom were the  directors  who received  such fees in
1999.  Board  members  do not earn  additional  compensation  for  service  on a
committee.

     At the 1999 Annual Meeting, the stockholders approved a new Directors Stock

<PAGE>

Option Plan (the "1999 Plan") to replace the 1994 Outside Directors Stock Option
Plan (the "1994 Plan").  Under the 1999 Plan,  each person  elected to the Board
who is not an employee will  receive,  on the date of his initial  election,  an
option to purchase 21,000 shares of Common Stock (an "Initial  Option").  On May
1st of each  year,  commencing  May 1, 1999,  each  non-employee  director  will
receive an option to purchase  10,000 shares of Common Stock if he has served as
a non-employee  director for at least six months prior to the May 1st grant date
(an  "Additional  Option").  Each option granted under the 1999 Plan will have a
ten-year term and the exercise  price of each option will be equal to the market
price of the Common  Stock on the date of the grant.  Each  Initial  Option will
vest in equal installments of 1/3 over a period of three years, commencing on
the date of the grant and each Additional Option will vest in its entirety on
the first anniversary of the grant.

     All options will become  exercisable  upon the vesting  thereof,  and shall
remain  exercisable for the remaining term of the option,  unless the director's
service as a  non-employee  director  terminates  prior to the expiration of the
term. If the grantee's service as a director  terminates prior to the expiration
of the option, the options will remain exercisable for a 90-day period following
termination  of service,  except (i) if a non-employee  director  resigns due to
disability,   the  options  will  remain  exercisable  for  180  days  following
termination,  and  (ii) if a  non-employee  director  dies  while  serving  as a
director,  or within 90 days  following  termination of service (180 days in the
case of disability),  the options will remain exercisable for 180 days following
the person's death.  After such period,  the options will terminate and cease to
be exercisable.  Messrs. Hendrickson and Bloom each have received under the 1999
Plan options to purchase  10,000  shares of Common Stock and, as of May 1, 2000,
each will receive an Additional Option to purchase 10,000 shares of Common
Stock.

     Under the 1994 Plan, each person who was an outside director at the time of
the adoption of the 1994 Plan was granted,  and each person who  subsequently is
elected as an outside director is granted,  a ten-year option to purchase 30,000
shares of Common  Stock at an exercise  price  equal to the market  price of the
Common Stock on the date of the grant. The options vest in equal increments over
the  three-year  period  following the grant.  If the  recipient's  service as a
director  terminates,  the option will expire three (3) months after the date of
such termination. Messrs. Hendrickson and Bloom each have received under the
1994 Plan grants of options to purchase 30,000 shares.

                                        3
<PAGE>

REPORT OF THE BOARD OF DIRECTORS ON 1999 EXECUTIVE COMPENSATION

     The entire Board of Directors  was  responsible  for  determining  the 1999
compensation  of the  four  executive  officers  of  the  Company.  This  Report
describes  the  policies  and  other   considerations   used  by  the  Board  in
establishing such compensation.
     The  members  of the Board are  familiar  with  various  forms and types of
remuneration  from reports of other public  corporations  and their own business
experience.
     The Board has determined that,  because the Company was still in a research
and preproduction  phase in 1999,  compensation for 1999 for executive  officers
could not be related  primarily to the  performance of the Company's stock or to
the annual profit  performance of the Company.  A primary  consideration for the
compensation of an executive  officer of the Company is his leadership effort in
the  development  of  proprietary  products and  processes,  and in planning for
future growth and  profitability.  Other significant  factors  considered by the
Board of Directors in determining executive officers' compensation were salaries
paid by other public companies in the health-care related biotechnology field to
comparable  officers,  the duties and responsibilities of the executive officers
in the past and as  projected,  their past  performance  and  commitment  to the
Company,  and incentives for future performance,  although no specific weighting
was allocated to any of these  considerations.  The executive officers were also
consulted with respect to their  compensation  and their plans for  compensation
for other  personnel in order to  coordinate  all  compensation  policies of the
Company.


     The Board of  Directors  determined  that no  bonuses  or salary  increases
should be paid to  executive  officers  in 1999,  primarily  on the basis of the
Company's  losses and the  projected  expenses  and cash flow  required  for the
further  development of the Company's oral and nasal calcitonin products as well
as the regulatory expenses for the Company's injectable form of calcitonin.

     The Board also  determined  that no stock  options be awarded to  executive
officers other than Jay Levy and James Gilligan for 1999, at the request of such
executive officers. During 1999, Jay Levy received two stock option grants under
the 1994 Employee Stock Option Plan; options to purchase 20,000 shares of Common
Stock are exercisable at $.75 per share and options to purchase 20,000 shares of
Common Stock are exercisable at $.63 per share. In addition, Jay Levy received a
grant under the 2000 Stock Option Plan to purchase 30,000 Shares of Common Stock
at an exercise price of $.63 per share. During 1999, James Gilligan received two
stock option  grants  under the 1994  Employee  Stock  Option  Plan;  options to
purchase 20,000 shares of Common Stock are  exercisable  at $.9375 per share and
options to purchase  39,000 shares of Common Stock are  exercisable  at $.63 per
share. In addition,  James Gilligan received a grant under the 2000 Stock Option
Plan to purchase  76,000 Shares of Common Stock at an exercise price of $.63 per
share. The aforementioned options were granted at fair market value.

     The compensation for the Chief Executive  Officer for 1999 was based on the
same  policies  and  considerations  set  forth  above  for  executive  officers
generally.

         Warren P. Levy
         Ronald S. Levy
         Jay Levy
         Robert F. Hendrickson
         Allen Bloom
<PAGE>

Employment Agreements

     The Company has entered into an employment agreement,  effective January 1,
2000,  with Dr.  Warren P. Levy for an initial term of 2 years.  Pursuant to the
agreement,  Dr. Levy is to serve as President and Chief Executive Officer of the
Company at an annual  salary of $160,000 for the initial year of the  agreement.
Salary increases beyond the first year are at the discretion of the Compensation
Committee.

     The Company has entered into an employment agreement,  effective January 1,
2000,  with Dr.  Ronald S. Levy for an initial term of 2 years.  Pursuant to the
agreement, Dr. Levy is to serve as Executive Vice President of the Company at an
annual  salary  of  $155,000  for  the  initial  year of the  agreement.  Salary
increases  beyond  the  first  year are at the  discretion  of the  Compensation
Committee.

     Each  agreement  provides  that,  after  the  initial  two-year  term,  the
agreement will be renewed on a  year-to-year  basis unless either party notifies
the other of the desire not to renew the  agreement  no later than three  months
prior to the scheduled termination date. Each agreement also provides that, upon
(a)  termination of the employment of the executive by the Company without cause
or (b)  resignation of the executive for good reason (which is defined to mean a
change of control of the  Company or a material  diminution  of the  executive's
responsibilities  without  his  consent),  the  Company  will  make  a  lump-sum
severance  payment to the  executive  equal to (i) the salary that the executive
would have earned for the  remaining  term of this  agreement,  if the remaining
term  (either the initial term or as extended) is more than one year or (ii) the
executive's  then-current  annual salary, if the remaining term of the agreement
(either the initial term or as extended) is one year or less.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     Executive compensation for 1999 was determined by the Board of Directors of
the Company  consisting  of Messrs.  Warren P. Levy,  Ronald S. Levy,  Jay Levy,
Robert F. Hendrickson, and Allen Bloom.

     Three of the five member Board of Directors, Warren P. Levy, Ronald S. Levy
and Jay Levy, are executive  officers of the Company.  Jay Levy is the father of
Warren and Ronald Levy.

                                       4
<PAGE>
     During 1995,  Warren P. Levy,  Ronald S. Levy, Jay Levy, and another family
member  loaned a total of  $1,905,000 to the Company,  of which  $1,850,000  was
secured by secondary  liens on the Fairfield plant and equipment and the Boonton
manufacturing  equipment.  The notes bear  interest at the Merrill  Lynch Margin
Loan Rate plus .25% (9.375% at April 1, 2000).  A total of $440,000 in principal
repayments  was made during 1996. In 1997, an aggregate of $200,000 in principal
amount was converted  into 57,200 shares of Common Stock.  In 1998, an aggregate
of $225,000 in principal amount of these loans was converted into 163,635 shares
of Common Stock. In each case, such  conversions were at a price slightly higher
than the then market price of the Common Stock. Warren Levy and Ronald Levy each
loaned to the Company an additional  $50,000 during 1999, leaving an outstanding
balance of  $1,140,000  at December 31, 1999.  During 1999,  Jay Levy loaned the
Company  $1,500,000  evidenced by demand notes bearing  interest at 6% per year.
During the third  quarter of 1999,  Jay Levy  loaned the  Company an  additional
$370,000  evidenced by term notes maturing  January 2002 and bearing interest at
6% per year,  and the  $1,500,000  of demand notes were  converted  into 6% term
notes  maturing  January  2002.  The  Company  has  granted  Jay Levy a security
interest in all of its  equipment  and a mortgage on its real property to secure
payment of the term notes,  which are senior to all notes payable to Warren Levy
and Ronald Levy. The terms of the notes require the Company to make  installment
payments  commencing  in October 1999 and ending in January 2002 in an aggregate
amount of $72,426 per month. No installment payments have been made to date. Jay
Levy has agreed to  temporarily  postpone  current  payments and has also agreed
that he will not,  prior to January 1, 2001,  declare  all or any portion of the
principal or the accrued  interest on the notes  immediately  due and payable by
reason of the failure of the Company to make, when due, any scheduled payment of
principal or interest on any of the notes.  No interest has been paid to date on
any of the  aforementioned  loans.  As of December  31, 1999,  accrued  interest
totalled $645,290.

EXECUTIVE COMPENSATION

     The  following  table  sets  forth,  for the  years  1999,  1998 and  1997,
compensation  paid to the Chief  Executive  Officer of the  Company  and to each
other  executive  officer  whose  compensation  in 1999 exceeded  $100,000,  for
services  rendered by such  executive  officers in all  capacities in which they
served:

SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>                                                                                                   All Other
                                      Annual Compensation              Long Term Compensation             Compensation(1)
                                     ---------------------             ----------------------             ---------------
                                                                         Awards                  Payouts
                                                                         ------                  -------
                                                           Other       Restricted
Name and                                                  Annual         Stock     Options/        LTIP
Principal Position         Year       Salary  Bonus    Compensation (2)  Award      SARs          Payouts
- ------------------         ----       ------  -----    ----------------  -----      ----          -------

<S>                        <C>       <C>        <C>       <C>             <C>        <C>            <C>          <C>
Warren P. Levy,            1999      $146,211   $-0-      $-0-            $-0-       $-0-           $-0-         $13,866
  President, Chief         1998       146,231    -0-       -0-             -0-        -0-            -0-          13,830
  Executive Officer        1997       145,549    -0-       -0-             -0-        -0-            -0-          13,810
  and Director
Dr. Ronald S. Levy,        1999       141,563    -0-       -0-             -0-        -0-            -0-          16,862
  Executive Vice           1998       141,618    -0-       -0-             -0-        -0-            -0-          16,792
  President and            1997       140,895    -0-       -0-             -0-        -0-            -0-          16,756
  Director
Dr. James P. Gilligan,     1999       139,216    -0-      7,235            -0-       135,000         -0-          -0-
  Vice President                                                                     shares
</TABLE>
<PAGE>

(1)  Represents  premium  paid by the  Company on  executive  split-dollar  life
     insurance.
(2)  Represents reimbursement for unused vacation days.


STOCK OPTION GRANTS DURING THE YEAR ENDED DECEMBER 31, 1999

     The following table sets forth certain information relating to stock option
grants to each of the executive officers named in the Summary Compensation Table
during the year ended December 31, 1999:
<TABLE>
<CAPTION>
                          Number        Percent
                        of Shares      of Total
                        Underlying   Option Shares     Exercise
                         Options      Granted to      Price per      Expiration     Grant Date
Name                     Granted     Employees (1)     Share (2)        Date         Value (3)
- ----                     -------     -------------     ---------        ----         ---------
<S>                        <C>           <C>          <C>            <C>             <C>
Dr. Warren P. Levy         0             0              --               --             --
Dr. Ronald S. Levy         0             0              --               --             --
Dr. James P. Gilligan      20,000        2.2%         $0.9375         3/31/09        $15,530
                        115,000(4)      12.8%         $0.63          11/5/09         $60,007
</TABLE>

(1)  Options exercisable for an aggregate of 900,000 shares of Common Stock were
     granted in 1999  consisting of options to purchase  418,000  shares granted
     under the 1994 Employee  Stock Option Plan and options to purchase  482,000
     shares granted under the 2000 Stock Option Plan.

                                       5
<PAGE>

(2)  Fair market value on the date of grant.
(3)  The fair value of the stock  options  granted in 1999 is estimated at grant
     date  using  the  Black-Scholes  option-pricing  model  with the  following
     weighted average assumptions:  dividend yield of 0%; expected volatility of
     74%; a risk-free interest rate of 6.4%; and expected life of 6 years.
(4)  Includes 76,000 options granted under the 2000 Stock Option Plan.

AGGREGATED OPTION EXERCISES AND YEAR-END OPTION VALUES

     The following  table sets forth  information as to the exercises of options
during the year ended December 31, 1999, and the number and value of unexercised
options held as of December 31, 1999, by each of the executive officers named in
the Summary Compensation Table:
<TABLE>
<CAPTION>
                               Exercises During             Shares Underlying                Value of Unexercised
                               The Fiscal Year              Unexercised Options              In-the-Money Options (1)
                            Number of
                            Shares         Value
                           Acquired      Realized     Exercisable      Unexercisable     Exercisable       Unexercisable
                           --------      --------     -----------      -------------     -----------       -------------
<S>                           <C>            <C>          <C>             <C>                  <C>              <C>
Dr. Warren P. Levy            0              0            0               0                    --               --
Dr. Ronald S. Levy            0              0            0               0                    --               --
Dr. James P. Gilligan         0              0            265,750         124,250              0                0
</TABLE>

- -------------------------
(1) Based upon a closing price of $0.57 on December 31, 1999.

SHAREHOLDER RETURN PERFORMANCE PRESENTATION

Set forth below is a line graph  comparing the yearly  percentage  change in the
cumulative  total  stockholder  return  on the  Company's  Common  Stock  to the
cumulative  total  return of the NASDAQ  Market  Index and of a peer group index
determined by Standard Industrial Classification (SIC) code.

COMPARISON OF CUMULATIVE TOTAL RETURN
OF COMPANY, INDUSTRY INDEX AND BROAD MARKET

[GRAPHIC- GRAPH PLOTTED TO POINTS LISTED BELOW]
<TABLE>
<CAPTION>


                                                   FISCAL YEAR ENDING
- -----------------------------------------------------------------------------------------------------------
<S>                              <C>           <C>          <C>         <C>           <C>          <C>
COMPANY/INDEX/MARKET            12/31/1994  12/31/1995   12/31/1996   12/31/1997   12/31/1998   12/31/1999

Unigene Laboratories, Inc.       100.00        55.26        85.53       110.53        50.00        24.00

Commercial Physical Research     100.00       194.12       172.67       196.96       216.21       292.38

NASDAQ Market Index              100.00       129.71       161.18       197.16       278.08       490.46

</TABLE>

                    Assumes $100 Invested on January 1, 1995
                          Assumes Dividends Reinvested
                        Fiscal Years Ending December 31.

The industry index chosen was:
SIC Code 8731 - Commercial Physical & Biological Research

                                       6
<PAGE>

The Broad Market index chosen was:
NASDAQ Market Index

The current composition of the industry index is as follows:

Abiomed Inc.                Kopin Corp.
AC Nielsen Corp.            Krug Internat Corp.
Affymetrix Inc.             Lifecell Corporation
Agritope Inc.               Liposome Co. Inc
American Superconductor     Maxygen Incorporated
Aurora Biosciences Corp.    Myriad Genetics Inc.
Bioreliance Corp.           Neopharm Inc.
Catalytica Inc.             Neose Technologies Inc.
Celgene Corp.               Neotherapeutics Inc.
Collateral Therapeutics     Neurocrine Biosciences
Commonwealth Biotech Inc.   Ophidian Pharmaceuticals
Conductus Inc.              Organogenesis Inc.
Covance Inc.                Parexel Internat CP
Cree Incorporated           Pharmaceutical Prod. Dev.
Curagen Corp.               Pharmacopeia Inc.
CV Therapeutics Inc.        Polymer Research of America
Datatrak International Inc. Quest Diagnostics Inc.
Depomed Inc.                Quintiles Transnational
Ecogen Inc.                 Research Frontiers Inc.
Electrosource Inc.          Satcon Technology Corp.
Energy Biosystems Corp.     Spire Corp.
Energy Conversn Devices     Summit Technology Inc.
Excel Technology Inc.       Superconductor Tech.
Gene Logic Inc.             Symyx Technologies Inc.
Genset ADR                  Synaptic Pharmaceutical
Incyte Pharmaceuticals      Tularik Incorporated
Innerdyne Inc.              Valence Technology Inc.
Irvine Sensors Corp.        Valentis Inc.
Kendle Internat Inc.        Xenova GR PLC ADS
KFX Inc.

                                       7
<PAGE>

                                   PROPOSAL 2
             APPROVAL OF ADOPTION OF THE UNIGENE LABORATORIES, INC
                             2000 STOCK OPTION PLAN

     The Board of Directors is  submitting to  stockholders  for approval at the
2000 Annual Meeting a proposal to adopt the Unigene Laboratories Inc. 2000 Stock
Option Plan to replace the 1994 Employee Stock Option Plan.

BACKGROUND
     In 1994,  the  Company's  Board of Directors  adopted and the  stockholders
approved the Unigene Laboratories, Inc. 1994 Employee Stock Option Plan, amended
in 1997,  (the "1994  Plan").  Under the terms of the 1994 Plan the  Company was
authorized to issue up to 2,250,000  shares of its common stock,  par value $.01
per share ("Common  Stock") pursuant to the exercise of stock options granted to
eligible  employees.  As of March 31, 2000,  364,460  shares of Common Stock had
been so issued and an additional  1,777,615 shares of Common Stock were reserved
for issuance upon the exercise of outstanding options, representing total grants
of 2,142,075 shares of Common Stock.

     The Board of Directors believes that stock options are an important element
of the Company's employee compensation program,  particularly for a company like
Unigene that wants to maximize  the  financial  resources  that it can devote to
product research and  development.  Because stock options increase in value only
if the price of the Common Stock increases,  options have the effect of aligning
the  financial   interests  of  the  Company's   employees  with  those  of  the
stockholders  by tying the return to the  employees to increases in  stockholder
value.  In  addition,  the grant of stock  options to  consultants  who  provide
services to the Company enables the Company to reduce the amount of cash that it
otherwise would incur to pay for these services.

     In order to enable the  Company to include  stock  options as an element of
the  Company's  employee  compensation  packages  and to issue stock  options as
compensation  to  consultants,  the Board of  Directors  has adopted the Unigene
Laboratories,  Inc. 2000 Stock Option Plan (the "Plan") and has directed that it
be submitted to stockholders for approval,  with the recommendation of the Board
of Directors that it be approved.

DESCRIPTION OF THE PLAN

     The following is a description of the material  features of the Plan.  This
description  is  qualified  in its  entirety  by the text of the  Plan  which is
attached  hereto  as  Attachment  A and is  hereby  incorporated  by  reference.

     Purpose.  The purpose of the Plan is to provide incentives to employees and
certain  consultants  of the Company by  providing  them with  opportunities  to
purchase  stock in the Company,  thereby  increasing  their  motivation  for and
interest in the Company's long term success.

     Administration. The Plan is required to be administered either by the Board
of Directors (the "Board") or by a committee (the  "Committee")  composed of not
less than two directors  each of whom is a  "non-employee  director"  within the
meaning of Rule 16b-3 under the Securities Exchange Act of 1934, as amended (the
"1934 Act").  The Board or the Committee has authority,  subject to the terms of
the Plan, to determine (i) the  employees  and  consultants  eligible to receive
option grants under the Plan, (ii) the employees and consultants to whom options
will be granted, (iii) in the case of employees,  whether the option is intended
to qualify as an "incentive  stock option"  within the meaning of Section 422 of
the Internal  Revenue Code of 1986 (an "Incentive  Stock Option") or whether the
option is not intended to be so qualified (a "Non-qualified Stock Option"), (iv)
the number of shares that are the subject of an option  grant,  (v) the times at

<PAGE>

which options are granted, (vi) the option exercise price, (vii) the term of the
option, and (viii) the date or dates upon which the option may be exercised, and
the installments,  if any, in which options may become exercisable. The Board or
the  Committee  also has the  authority  to  interpret  the Plan and to make all
determinations  necessary  or  advisable  for the  administration  of the  Plan.

     Eligibility.  Options may be granted under the Plan only (i) to persons who
are employees (including directors who are employees) of the Company and (ii) to
persons  who are  employed  as  consultants  to the  Company (A) who are natural
persons,  (B) provide bona fide services to the Company other than in connection
with the offer or sale of securities in a capital-raising  transaction,  and (C)
who are not  engaged  in  activities  that  directly  or  indirectly  promote or
maintain a market for the Company's securities.  Employees may be granted either
Incentive  Stock Options or  Non-qualified  Stock  Options.  Consultants  may be
granted only Non-qualified Stock Options.

     Shares  Available.  A total of 4 million  shares  are  available  for stock
option grants under the Plan. The shares issued upon the exercise of options may
be either  previously  unissued shares or shares held in treasury.  In the event
that an outstanding  option granted under the Plan expires,  or is  surrendered,
terminated or cancelled prior to the exercise thereof,  the underlying shares of
Common Stock will again be available for stock option grants under the Plan.

     Term of the Plan. The Plan, if approved by  stockholders at the 2000 Annual
Meeting, will become effective on the date of the Annual Meeting (the "Effective
Date").  Options  may be  granted  under the Plan at any time prior to the tenth
anniversary of the Plan, unless the Plan is terminated earlier by the Board.

     Terms of Stock Options.  All options  granted under the Plan are subject to
the following terms and conditions:

     Option Exercise Price. The exercise price of options granted under the Plan
may not be less than Fair Market Value  (which is defined  generally by the Plan
to mean the market price) of the Common Stock at the time the option is granted.

                                       8
<PAGE>

     Term of Options.  Each option  granted  under the Plan will expire no later
than ten years after the date of its grant.

     Vesting. Options granted under the Plan will vest and become exercisable in
such  installments  and at such  times  as are  determined  by the  Board or the
Committee.

     Payment of  Exercise  Price.  The  exercise  price of the stock  options is
payable in cash, or to the extent authorized by the Board or the Committee prior
to the time the option is  exercised,  in shares of Common  Stock that have been
owned by the  person  exercising  the  option  for at least  six  months or in a
combination of cash and shares.  The value of a share of Common Stock  delivered
in payment of the  exercise  price will be equal to the Fair  Market  Value of a
share of Common Stock on the date the option is exercised.

     Limitation on Incentive  Stock  Options.  The  aggregate  Fair Market Value
determined  at the time of the grant of shares with  respect to which  Incentive
Stock  Options  are  exercisable  (under  this Plan and all  other  plans of the
Company and its parent and subsidiary companies) for the first time by a grantee
during any calendar year may not exceed $100,000

     Effect of  Termination of Employment.  Unless  otherwise  determined by the
Board or the  Committee,  any option  granted under the Plan will terminate upon
termination  of the grantee's  employment  with the Company  whether by death or
otherwise, and no shares of Common Stock may thereafter be purchased pursuant to
the exercise of the option, with the following exceptions:  (i) upon termination
of employment (other than by reason of death or for cause), a grantee may, for a
period of three months  following the date of  termination,  purchase all or any
part of the shares of Common  Stock that the  grantee  was  entitled to purchase
under  the  option as of the date of  termination,  and (ii) upon the death of a
grantee while employed by the Company or within the three-month  period referred
to in clause  (i),  the  grantee's  estate or the person to whom such  grantee's
rights  under the option  are  transferred  by will or the laws of  descent  and
distribution  may,  during  a  period  of 180  days  following  the  date of the
grantee's death, purchase all or any part of the shares of Common Stock that the
grantee  was  entitled  to  purchase  under  the  option  as of the  date of the
grantee's  death.  If  employment  of a grantee by the Company is  terminated by
reason of  discharge  for cause,  the option will  terminate  upon the giving of
notice of termination  to the grantee or, if earlier,  on the  termination  date
stated in the option.  The term "cause" means discharge from employment  because
of fraud,  disclosure  of trade  secrets,  activities  in  competition  with the
business of the Company,  misappropriation of assets of the Company, intentional
acts materially harmful to the Company or its business, or conviction of a crime
involving moral turpitude.

         No  Transferability.  Options granted under the Plan are not assignable
or  transferable  by the  grantee,  except  by will or  pursuant  to the laws of
descent and  distribution.

     Amendment or  Termination of the Plan. The Board may terminate or amend the
Plan in any respect at any time provided that, except for permitted adjustments,
(i) no action of the Board  may  alter or impair a  grantee's  rights  under any
outstanding option without the grantee's consent,  and (ii) without the approval
of the holders of a majority of the Common  Stock  present and  entitled to vote
thereon  at a meeting  duly held for such  purpose  (A) the  number of shares of
Common Stock that may be issued under the Plan shall not be  increased,  (B) the
provisions regarding eligibility shall not be modified, (C) the initial purchase
price at which stock  options  may be granted  shall not be reduced to less than
Fair  Market  Value,  and  (D) the  expiration  date of the  Plan  shall  not be
extended.
<PAGE>

     Adjustments. To the extent deemed equitable and appropriate by the Board or
the  Committee  in its sole  discretion,  the number,  price and class of shares
covered by each option and the total number of shares that may be sold under the
Plan may be appropriately adjusted to reflect any stock dividend, stock split or
share  combination of the Common Stock or any  recapitalization  of the Company,
spin-off,  split-up,  rights offering,  merger,  consolidation,  reorganization,
exchange of shares or other change in the corporate  structure,  liquidation  or
dissolution.

     Effect  of  Certain  Transactions.   In  the  event  of  a  dissolution  or
liquidation  of the Company,  or a transfer of all or  substantially  all of its
assets,  or a merger or  consolidation,  or other corporate  change,  unless the
acquiring,  surviving  or  continuing  entity  agrees in  writing  to assume the
obligations  under the options issued under the Plan, the Board or the Committee
may, in its sole discretion,  terminate options as of the effective date of such
event or accelerate the date when any or all installments of options will become
exercisable.

USE OF PROCEEDS

     Proceeds  from the sale of shares of Common Stock  pursuant to the exercise
of stock options will be used for general corporate purposes.

FEDERAL INCOME TAX CONSEQUENCES

     Summarized  below are the material  federal income tax  consequences of the
2000 Stock Option Plan,  as they relate to stock  options  granted to employees,
based on applicable  provisions of the federal  income tax laws and  regulations
currently  in  effect.   The  tax  consequences  of  stock  options  granted  to
consultants may differ.

     Non-qualified  Stock Options.  In general, an individual will not recognize
income for federal  income tax  purposes  when a  Non-qualified  Stock Option is
granted, and the Company will not be entitled to a federal income tax deduction.
When a  grantee  exercises  a  Non-qualified  Stock  Option,  the  grantee  will
recognize ordinary income for federal income tax purposes to the extent that the

                                       9
<PAGE>

fair market  value of the shares of Common Stock  received  exceeds the exercise
price.  The  amount of  ordinary  income  recognized  by an  individual  will be
deductible  by the  Company  in the year that the  income is  recognized  by the
individual.  Upon subsequent disposition of the shares of Common Stock, any gain
or loss relative to the holder's tax basis in the shares is taxable  either as a
short-term or long-term capital gain or loss,  depending upon the length of time
that the shares of Common Stock are held.

Incentive Stock Options. In general, an individual will not recognize income for
federal  income tax purposes  when an Incentive  Stock Option is granted or when
the Incentive Stock Option is exercised, and the Company will not be entitled to
a federal  income tax  deduction.  When a grantee  exercises an Incentive  Stock
Option,  the grantee  generally will not recognize income for federal income tax
purposes and the Company will not recognize taxable income either on the date of
grant or on the date of its  timely  exercise.  However,  the excess of the fair
market  value of the Common  Stock  received  upon the  exercise of an Incentive
Stock  Option over the option  exercise  price is  includable  in the  grantee's
income for purposes of the federal  alternative  minimum tax.

Provided  that the  grantee  has not  disposed  of the  shares of  Common  Stock
acquired  upon the exercise of an Incentive  Stock Option within two years after
the  date  of  grant  or  within  one  year  after  the  date  of   exercise  (a
"Disqualifying  Disposition"),  upon the disposition of the shares,  the grantee
will realize long-term capital gain or loss in an amount equal to the difference
between  the  sale  price  and  the  option  exercise  price.  In the  case of a
Disqualifying Disposition,  the grantee generally will recognize ordinary income
at the time of a  Disqualifying  Disposition  to the extent of the lesser of (i)
the  difference  between the  exercise  price and the fair  market  value of the
Common Stock on the date the  Incentive  Stock Option is exercised  and (ii) the
difference   between  the  exercise  price  and  the  amount  realized  on  such
Disqualifying  Disposition,  and the  balance  of any gain or any  loss  will be
treated as a short-term or long-term  capital gain or loss,  depending  upon the
length of time that the Common  Stock is held.  The Company is not entitled to a
deduction for federal  income  purposes upon either the exercise of an Incentive
Stock Option or upon disposition of the shares of Common Stock acquired pursuant
to such  exercise,  except to the extent  that the grantee  recognizes  ordinary
income in a Disqualifying Disposition.

NEW PLAN BENEFITS

     Grants of stock options under the Plan,  if approved by  stockholders,  are
subject  to the  discretion  of the  Board or the  Committee.  Accordingly,  the
benefits that any employee or group of employees might receive under the Plan in
the future is not  determinable.  The closing price of the Common Stock on April
13, 2000, was $2.22.

     In November  1999,  the Board  granted  under the Plan to  employees of the
Company stock options to purchase an aggregate of 482,000 shares of Common Stock
at an  exercise  price of $0.63 per  share.  In the  event  that the Plan is not
approved by the  stockholders at the Annual  Meeting,  these stock option grants
will be  cancelled.  The  following  table shows the  allocation of these grants
among certain persons and groups:

                                       Number of Options
Warren Levy                                    0
Ronald Levy                                    0
James Gilligan                            76,000
All executive officers as a group        106,000
All directors who are not
    executive officers as a group              0
All employees                            482,000
<PAGE>

     All future stock  option  grants will be awarded at the  discretion  of the
Board or the Committee, and therefore are not determinable at this time.

VOTE REQUIRED

     Approval  of the Plan  requires  the  affirmative  vote of the holders of a
majority  of the  shares of Common  Stock  present,  in person or by proxy,  and
entitled to vote at the Annual Meeting.

RECOMMENDATION OF THE BOARD OF DIRECTORS

     The Board of Directors  recommends that  stockholders vote FOR the adoption
of the 2000 Stock Option Plan.

                                       10
<PAGE>

                                   PROPOSAL 3
            RATIFICATION OF THE APPOINTMENT OF INDEPENDENT AUDITORS

     The  Board  of  Directors  has  appointed  KPMG  LLP,   independent  public
accountants,  to serve as the Company's independent auditors for the fiscal year
commencing January 1, 2000.  Although not required by the Company's  Certificate
of Incorporation  or By-Laws,  the Board of Directors is submitting to a vote of
the  stockholders  a proposal to ratify the  appointment  of KPMG LLP.  KPMG LLP
served as the  independent  auditors for the Company for the year ended December
31, 1999. A representative of the firm will be present at the meeting to respond
to appropriate  questions and will have the opportunity to make a statement,  if
such representative desires to do so.

     Ratification of the  appointment of KPMG LLP requires the affirmative  vote
of the holders of a majority of the shares of Common Stock present, in person or
by proxy,  and  entitled to vote at the Annual  Meeting.

     The Board of Directors recommends a vote FOR the ratification of KPMG LLP.

OTHER MATTERS

     The Board of Directors  of the Company  does not know of any other  matters
that are likely to be brought before the meeting. However, in the event that any
other  matters  properly  come  before the  meeting,  the  persons  named in the
enclosed form of proxy will vote all proxies  received in accordance  with their
judgment on such matters.

PROPOSALS BY STOCKHOLDERS

     Stockholder  proposals  intended to be presented at the 2001 Annual Meeting
must be received by the Company on or before  December 30, 2000,  in order to be
considered for inclusion in the Company's  proxy statement and form of proxy for
the Annual Meeting,  and must also meet the other  requirements set forth in the
rules of the Securities  and Exchange  Commission  relating to such  stockholder
proposals. If the proposal is received by the Company less than 45 days prior to
the anniversary of the mailing date of this proxy  statement,  the persons named
as proxies in the Company's proxy material for the 2001 Annual Meeting will have
the discretionary  authority to vote on the matter in accordance with their best
judgment without disclosure in the proxy statement of such matter or of how the
proxyholders intend to exercise their discretionary voting authority.

SOLICITATION OF PROXIES

     The cost of preparing,  assembling  and mailing this Proxy  Statement,  the
Notice of Meeting and the  enclosed  form of proxy will be borne by the Company.
In addition to the  solicitation of proxies by use of the mails, the Company may
utilize the  services of some of its officers  and regular  employees  (who will
receive no  compensation  therefor  in addition to their  regular  salaries)  to
solicit  proxies  personally  and by  telephone  and  telefax.  The  Company has
retained Regan & Associates,  Inc. to aid in the  solicitation  of proxies,  for
which such firm will be paid a fee of $6,500, including reimbursable expenses.

                                              By Order of the Board of Directors


                                              RONALD S. LEVY
                                              Secretary
Fairfield, New Jersey
April 28, 2000

                                       11
<PAGE>

                                                                    Attachment A

                           UNIGENE LABORATORIES, INC.
                             2000 STOCK OPTION PLAN

     1. Purpose.  This 2000 Stock Option Plan (the "Plan) is intended to provide
incentives to employees and certain  consultants of Unigene  Laboratories,  Inc.
(the  "Company")  and future  controlled  subsidiaries  by  providing  them with
opportunities  to  purchase  stock  in the  Company,  thereby  increasing  their
motivation  for and  interest  in the  Company's  long  term  success.  The term
"Company" includes controlled subsidiaries where the context requires.

     2.  Administration.  The Plan shall be administered  either by the Board of
Directors of the Company (the "Board") or by a Committee  (the  "Committee")  of
not less than two directors of the Company.  Each member of such Committee shall
be a  "Non-Employee  Director"  as that term is then  defined  under  Rule 16b-3
promulgated  under the  Securities  Exchange Act of 1934, as amended  ("Exchange
Act"), or any successor statute or regulation regarding the same subject matter.

     The Board or the Committee  shall have  authority,  subject to the terms of
the Plan, to (i) determine the employees and  consultants  eligible for grant of
options under the Plan,  (ii)  determine the employees and  consultants  to whom
options shall be granted, (iii) determine in the case of employees,  whether the
option is an  Incentive  Stock  Option or a  Non-qualified  Stock  Option,  (iv)
determine  the number of shares to be covered by each option,  (v) determine the
time or times at which  options  shall be  granted,  (vi)  determine  the option
price,  (vii)  determine  the term of the option,  (viii)  determine the date or
dates upon which the option may be exercised,  and the installments,  if any, in
which options may become exercisable, (ix) determine the terms and provisions of
the instruments by which options shall be evidenced, and (x) interpret the Plan.
The Board or the Committee,  as applicable,  also shall have exclusive authority
to make all determinations  necessary or advisable for the administration of the
Plan.

     No member  of the Board or the  Committee  shall be liable  for any  action
taken or omitted or for any determination made in good faith with respect to the
Plan or any option granted under the Plan.

     3.  Eligibility.  Options  may be  granted  only  (i) to  persons  who  are
employees (including directors who are employees) of the Company,  which, in the
discretion of and as conclusively determined by the Board or the Committee,  may
include  employees  on  authorized  leave of absence and (ii) to persons who are
employed as consultants to the Company who (A) are natural persons,  (B) provide
bona fide  services to the Company  other than in  connection  with the offer or
sale of securities in a capital-raising  transaction, and (C) are not engaged in
activities  that  directly  or  indirectly  promote or maintain a market for the
Company's securities.

     4. Stock.  The stock as to which  options  may be granted is the  Company's
common  stock,  par value $.01 per share  ("Common  Stock").  When  options  are
exercised,  the  Company may either  issue  unissued  shares of Common  Stock or
transfer issued shares of Common Stock held in its treasury. The total number of
shares of Common  Stock that may be sold  under the Plan  shall not exceed  four
million  (4,000,000)  shares  (subject  to  adjustment  as provided in Section 7
hereof).  In the event  that any  outstanding  option  under  the Plan,  for any
reason,  expires,  is  surrendered  or terminated  or is cancelled  prior to the
exercise  thereof with respect to any shares of Common  Stock  covered  thereby,
such shares shall be available  for  re-offering  under the Plan.

     5.  Granting of Options.  Options may be granted under the Plan at any time
prior to the tenth (10th)  anniversary  of the effective date of the Plan as set
forth in Section 10 hereof.  The date of grant of an option under the Plan shall
be the date on which the option is awarded by the Committee or the Board.

     6. Terms and Conditions of Options.  Options granted to employees may be in
the form of "incentive  stock options" as that term is defined in Section 422 of
the Internal Revenue Code of 1986, as amended ("Code"), herein called "Incentive
Stock Options," or in the form of options which are not described in Section 422
or Section 423 of the Code,  herein called  "Non-qualified  Stock Options." Only
Non-qualified Stock Options may be granted to consultants. Options granted under
this Plan shall be evidenced by instruments in such form as the Committee or the
Board may from time to time approve.  Such options and the instruments issued to
evidence such options shall conform to the following terms and conditions:

(a) Number of Shares.  The  option  shall be  granted  for a specific  number of
    shares of Common Stock.

(b) Option Price.  The purchase price at which an option may be granted shall be
    not less  than the Fair  Market  Value of the  Common  Stock at the time the
    option is granted or the par value  thereof,  if any,  whichever is greater.
    "Fair Market Value" of a share of Common Stock on any date means the closing
    sale price of a share of Common  Stock as reflected in the report of trading
    by the principal  quotation  service,  market or stock exchange on which the
    Common  Stock is traded or listed on such date (or,  if no such  shares were
    publicly  traded on that date,  the next preceding date on which such shares
    were so  traded) as  published  in The Wall  Street  Journal or in any other
    publication selected by the Board or the Committee;  provided, however, that
    if shares of Common Stock shall not have been publicly  traded for more than
    ten (10) days immediately preceding such date, then the Fair Market Value of
    a share of Common Stock shall be determined by the Board or the Committee in
    such manner as it may deem  appropriate  and its decision shall be final and
    binding.

(c) Payment. The exercise price shall be payable upon the exercise,  in whole or
    in part, of the option, in cash, or to the extent authorized by the Board or
    the Committee prior to the time the option is exercised, in shares of Common
    Stock that have been owned by the person  exercising the option for at least

                                      A-1
<PAGE>

    six months or in a combination of cash and such shares. The value of a share
    of Common Stock delivered in payment of the exercise price shall be its Fair
    Market Value on the date the option is exercised.  No shares shall be issued
    or transferred to an optionee until full payment therefor has been made.
(d) Term of Options.  Each option  granted  shall  expire no later than ten (10)
    years after the date of its grant.
(e) Exercise of Option.  Each option  shall  become  exercisable  in one or more
    installments  at the time or times as  specified in the grant of the option.
    Once an  installment  becomes  exercisable,  it shall remain  exercisable in
    whole  or in  part  until  expiration  or  termination  of  the  option.  No
    fractional  shares shall be issued or cash adjustment for fractional  shares
    made upon exercise of an option.

(f) Death and Other  Termination of Employment.  Unless otherwise  determined by
    the Board or the  Committee  and  specified in the  applicable  stock option
    agreement,  any option that has not theretofore expired shall terminate upon
    termination of the optionee's  employment by the Company whether by death or
    otherwise,  and no shares  of  Common  Stock  may  thereafter  be  purchased
    pursuant to such option, except that

     (i)  Upon termination of employment  (other than by death or for Cause), an
          optionee may, within three (3) months after the date of termination of
          employment,  purchase  all or any part of the  shares of Common  Stock
          which such optionee was entitled to purchase  under such option on the
          date of termination of employment.
     (ii) Upon the death of any optionee while employed by the Company or within
          the  three-month  period  referred to in Section  6(f)(i)  above,  the
          optionee's  estate or the person to whom such optionee's  rights under
          the  option  are  transferred  by will  or the  laws  of  descent  and
          distribution  may, within one hundred eighty (180) days after the date
          of such  optionee's  death,  purchase all or any part of the shares of
          Common Stock which such  optionee was entitled to purchase  under such
          option  on the date of  death.
          Nothing in this Section 6(f) shall authorize the exercise of an option
          after the  expiration of the exercise  period  therein  provided,  nor
          later than ten (10) years after the date of grant.
     (iii)If  employment  of an optionee by the Company is  terminated by reason
          of discharge for Cause,  the option shall terminate upon the giving of
          notice of  termination  to the  optionee  or on the  termination  date
          stated in the option,  whichever is earlier.  The term  "Cause"  shall
          mean discharge from employment  because of fraud,  disclosure of trade
          secrets,  activities in competition  with the business of the Company,
          misappropriation of assets of the Company, intentional acts materially
          harmful  to the  Company or its  business,  or  conviction  of a crime
          involving moral turpitude.
(g)  Assignability.  No option  granted  under the Plan shall be  assignable  or
     transferable  by the optionee  except by will or by the laws of descent and
     distribution, and during the lifetime of the optionee, each option shall be
     exercisable  only by the  optionee  or a duly  appointed  committee  for an
     incompetent optionee.
(h)  Taxes and  Withholding.  The Company's  obligation to deliver shares and/or
     property   upon  the  exercise  of  any  option  or  to  accept  shares  in
     consideration of the exercise price shall be subject to applicable federal,
     state and local taxes and withholding requirements.
(i)  Limitations  on Incentive  Stock Options.  Notwithstanding  anything to the
     contrary herein set forth:
     (i)  The  option  price  under an  Incentive  Stock  Option  granted  to an
          individual  who,  at the  time  the  option  is  granted,  owns  stock
          possessing  more than ten percent (10%) of the total  combined  voting
          power of all classes of stock of the Company shall be 110% of the Fair
          Market  Value of the stock at the time of grant and the term  shall be
          for no more than five (5) years.
     (ii) The  aggregate  Fair  Market  Value of shares  with  respect  to which
          Incentive Stock Options are exercisable (under this Plan and all other
          plans of the Company and its parent and subsidiary  companies) for the
          first time by an optionee  during any  calendar  year shall not exceed
          $100,000,  applied to such options in the order granted. The aggregate
          Fair  Market  Value of shares of stock shall be  determined  as of the
          time the option with respect to such shares is granted.
     (iii)All options  granted as  Incentive  Stock  Options  shall  comply with
          subsection  (b) of Section 422 of the Code.
      (iv)Each optionee who is granted  Incentive  Stock Options  promptly shall
          inform  the  Company  of the date and  terms  of  disposition  by such
          optionee of any Common  Stock issued upon  exercise of such  Incentive
          Stock Options.
(j)  Rights as a Stockholder.  An optionee shall have no rights as a stockholder
     of the Company with  respect to any shares  covered by his option until the
     issuance of a stock certificate to him for such shares. No adjustment shall
     be made for dividends or other rights for which the record date is prior to
     the  issuance of such stock  certificate,  except as set forth in Section 7
     herein.
(k)  Securities Act and Other Provisions. The instruments evidencing options may
     contain such other provisions, not inconsistent with the Plan, as the Board
     or  the  Committee  deems  advisable.  Among  these  provisions  may  be  a
     requirement that an optionee  represent to the Company in writing,  when an
     option is granted, and when he purchases shares on its exercise, that he is
     accepting  such option,  or  purchasing  such shares,  unless they are then
     covered by an effective  registration statement under the Securities Act of
     1933, as amended ("Securities Act"), for his own account for investment and
     not with a view to distribution of any such shares.  The stock  certificate
     issued upon  exercise of the option may bear such legend as counsel for the

                                      A-2
<PAGE>

     Company may deem  advisable  in  connection  with the  Securities  Act. The
     Company  shall have no  obligation  to register  the shares  issuable  upon
     exercise of the options  granted  hereunder  under the Securities Act or to
     list such shares on any quotation  service,  market or stock exchange or to
     continue such registration or listing.

     7. Adjustments,  Termination and Acceleration of Options in Certain Events.
To the extent deemed  equitable and appropriate by the Board or the Committee in
its sole  discretion,  the  number,  price and class of shares  covered  by each
option and the total  number of shares  that may be sold under the Plan shall be
appropriately  adjusted  to reflect  any stock  dividend,  stock  split or share
combination  of the  Common  Stock  or  any  recapitalization  of  the  Company,
spin-off,  split-up,  rights  offering,  and in  any  merger  or  consolidation,
reorganization,  exchange of shares, or other change in the corporate  structure
("Corporate Change"),  liquidation or dissolution.  Any option granted under the
Plan may pertain to the  securities  and other  property which holders of Common
Stock   would  be   entitled   to  receive  in   connection   with  such  event.
Notwithstanding the foregoing, and unless the acquiring, surviving or continuing
entity  agrees in writing to assume the  obligations  under the  option,  in the
event of a dissolution or  liquidation  of the Company,  or a transfer of all or
substantially  all of its assets,  or a merger or  consolidation,  or  Corporate
Change,  the  Board or the  Committee  may,  in its sole  discretion,  terminate
options as of the effective  date of such event or accelerate  the date when any
or all installments of options shall become  exercisable.  Options granted under
the Plan or any other plan need not be treated  identically  by the Board or the
Committee  with  respect  to  termination,   acceleration,  or  assumption.  All
decisions  of the  Committee or the Board  hereunder  shall be final and binding
upon the option holder;  provided,  however,  no Incentive  Stock Option granted
pursuant to the Plan shall be adjusted  or  accelerated  in a manner that causes
such  Incentive  Stock  Option to fail to qualify as an  Incentive  Stock Option
within the meaning of Section 422 of the Code.

     8. Effect on Optionee's  Rights.  All payments and benefits  under the Plan
shall  constitute  special  benefits  and shall not affect the level of benefits
provided  to  or  received  by  any  optionee  (or  the  optionee's   estate  or
beneficiaries)  as part of any other employee  benefit plan of the Company.  The
Plan  shall  not be  construed  to affect in any way an  optionee's  rights  and
obligations  under  any  other  plan  maintained  by the  Company  on  behalf of
employees.  Nothing in the Plan or in any option  granted  pursuant  to the Plan
shall confer upon any employee  the right to continue in the  employment  of the
Company or restrict the right of the Company to terminate the  employment of any
employee.

     9. Indemnification of Board and Committee. In addition to such other rights
of indemnification as they may have as members of the Board or as members of the
Committee,  the members of the Board and the Committee  shall be  indemnified by
the  Company  against  all costs and  expenses  reasonably  incurred  by them in
connection  with any claim,  action,  suit or proceeding to which they or any of
them may be or become a party by reason of any  action  taken or  failure to act
under or in  connection  with the Plan or any  option  granted  thereunder,  and
against  all  amounts  paid by them in  satisfaction  of a judgment  in any such
action, suit or proceeding, except a judgment based upon a finding of bad faith.
Upon the making of any such claim or  commencement  of any such action,  suit or
proceeding,  a Board or  Committee  member  shall notify the Company in writing,
giving the Company an  opportunity,  at its own  expense,  to handle,  settle or
defend the same  before such Board or  Committee  member  undertakes  to handle,
settle or defend the same on his own behalf.

     10. Terms and Amendments of the Plan. The Plan shall become  effective upon
the date of approval of the Plan by the  stockholders of the Company at the 2000
Annual Meeting  ("Effective Date") and shall, with the exception of options then
outstanding,  expire on the tenth (10th)  anniversary of the Effective Date, and
no option shall be granted  under the Plan after its  expiration.  The Board may
terminate or amend the Plan in any respect at any time; provided that, except as
provided  in  Section  7 of  the  Plan:  (a)  no  action  of  the  Board  or the
stockholders  of the Company may alter or impair an optionee's  rights under any
outstanding  option  without his  consent,  and (b) without the  approval of the
holders of a majority of all  securities of the Company  present in person or by
proxy and entitled to vote thereon at a meeting duly held,  (i) the total number
of shares  that may be sold  under the Plan  shall  not be  increased,  (ii) the
provisions of Section 3, regarding eligibility, shall not be modified, (iii) the
initial  purchase  price at which  stock  options  may be  granted  shall not be
reduced to less than Fair Market Value and (iv) the expiration  date of the Plan
shall not be extended.

     11. Use of Proceeds.  Proceeds  from the sale of stock  pursuant to options
granted under the Plan shall constitute general funds of the Company.

     12.  Pronouns.  Pronouns used in this Plan in the masculine shall be deemed
to include the feminine and pronouns in the singular  shall be deemed to include
the plural,  and the reverse,  as  appropriate  in the context where the pronoun
appears.

                                      A-3

<PAGE>

                                 REVOCABLE PROXY
                           UNIGENE LABORATORIES, INC.

[ X ]  PLEASE MARK VOTES
       AS IN THIS EXAMPLE

                   PROXY SOLICITED BY THE BOARD OF DIRECTORS
                               FOR ANNUAL MEETING
                                  JUNE 6, 2000

The undersigned stockholder of Unigene Laboratories, Inc. hereby appoints Warren
P. Levy,  Ronald S. Levy and Jay Levy,  and each of them,  as the  undersigned's
proxies (with the power of substitution), to vote all the shares of Common Stock
of Unigene Laboratories, Inc. which the undersigned would be entitled to vote at
the Annual Meeting of Stockholders of Unigene  Laboratories,  Inc. to be held on
June 6, 2000 at 11:00 A.M., Eastern Daylight time, and any adjournments thereof,
on the following matters:
<PAGE>

                        Please be sure to sign and date
                          this Proxy in the box below.


                        ---------------------------------
                                      Date


                        ---------------------------------
                             Stockholder sign above


                        ---------------------------------
                          Co-holder (if any) sign above



1. Election of directors

Jay Levy, Ronald S. Levy,
Warren P. Levy, Robert F. Hendrickson
and Allen Bloom.

                                    With-               For All
            [  ]  For         [  ]  hold          [  ]  Except

INSTRUCTION: To withhold authority to vote for any individual nominee, mark "For
All Except" and write that nominee's name in the space provided below.

- --------------------------------------------------------------------------------

2. Approval of the adoption of the Company's 2000 Stock Option Plan.

            [  ]  For         [  ]  Against        [  ]  Abstain


3.  Ratification of the  appointment of KPMG LLP as independent  auditors of the
    Company.

            [  ]  For         [  ]  Against        [  ]  Abstain


4. In  their  discretion  in the  transaction  of any  other  business  that may
   properly come before such meeting.


The undersigned hereby revokes any proxy heretofore given.

     Please  sign  exactly  as your  name  appears  on this  card.  If  stock is
registered  in the names of two or more  joint  owners or  trustees,  each joint
owner  or  trustee  should  sign  this  proxy.  When  signing  as  an  executor,
administrator, trustee, guardian, agent or attorney, please give your full title
as such.

   Detach above card, sign, date and mail in postage paid envelope provided.
                           UNIGENE LABORATORIES, INC.

     This proxy will be voted in accordance with  instructions  specified above,
but in the absence of any instructions  will be voted "FOR" Items 1, 2 and 3. If
any other  business is presented at the meeting,  the proxies are  authorized to
vote thereon in their discretion.
     The Board of Directors recommends a vote FOR Items 1, 2 and 3 noted above.


                              PLEASE ACT PROMPTLY
                    SIGN, DATE & MAIL YOUR PROXY CARD TODAY




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