QUIDEL CORP /DE/
4, 2000-01-10
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

- --------                               -----------------------------
 FORM 4                                        OMB APPROVAL
- --------                               -----------------------------
- ----- Check this box if no longer      OMB Number:       3235-0287
      subject to Section 16. Form 4    Expires: September 30, 1998
- ----- or Form 5 obligations may        Estimated average burden
      continue. SEE Instruction 1(b).  hours per response .... 0.5
                                       ------------------------------

              UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                       WASHINGTON, D.C. 20549

                 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

     Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
      Section 17(a) of the Public Utility Holding Company Act of 1935 or
             Section 30(f) of the Investment Company Act of 1940

(Print or Type Responses)

- - ----------------------------------------------------------------------------
1. Name and Address of Reporting Person*

   Feinberg,        Larry                  N.
- - ---------------------------------------------------
   (Last)          (First)              (Middle)

   c/o Oracle Investment Management, Inc.
   712 Fifth Avenue, 45th Floor
- - ----------------------------------------------------
                   (Street)

   New York,        New York              10019
- - ----------------------------------------------------
   (City)           (State)               (Zip)

- - ----------------------------------------------------------------------------
2. Issuer Name and Ticker or Trading Symbol

   Quidel Corp.
   QDEL
- - ----------------------------------------------------------------------------
3. IRS or Social Security Number of Reporting Person (Voluntary)

- - ----------------------------------------------------------------------------
4. Statement for Month/Year

   12/99
- - ----------------------------------------------------------------------------
5. If Amendment, Date of Original (Month/Year)

- - ----------------------------------------------------------------------------
6. Relationship of Reporting Person(s) to Issuer (Check all applicable)

   [ ] Director
   [x] 10% Owner
   [ ] Officer (give title below)
   [ ] Other (specify below)



- - ----------------------------------------------------------------------------
7. Individual or Joint/Group Filing (Check Applicable Line)

   [x] Form filed by One Reporting Person
   [ ] Form filed by More than One Reporting Person
- - ----------------------------------------------------------------------------
<PAGE>



<TABLE>
<CAPTION>
TABLE I--NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY
OWNED
- ----------------------------------------------------------------------------
1. Title of Security  2. Trans-  3. Trans-      4. Securities Acquired (A)
   (Instr. 3)            action     action         or Disposed of (D)
                         Date       Code           (Instr. 3, 4 and 5)
                         (Month/    (Instr. 8)  --------------------------
                          Day/      -----------    Amount   (A) or   Price
                          Year)     Code    V               (D)

- ----------------------------------------------------------------------------
       <S>                 <C>       <C>   <C>      <C>     <C>       <C>
- ----------------------------------------------------------------------------
Common Stock            12/03/99      P            30,000    A(3)   $5.2214
- ----------------------------------------------------------------------------
Common Stock            12/15/99      P            15,000    A(4)    6.3958
- ----------------------------------------------------------------------------
Common Stock            12/31/99      P             3,400    A(5)    6.9030
- ----------------------------------------------------------------------------
Common Stock              NONE
- ----------------------------------------------------------------------------



- ----------------------------------------------------------------------------
5. Amount of     6. Ownership        7. Nature of
   Securities       Form: Direct        Indirect
   Beneficially     (D) or Indirect     Beneficial
   Owned at End     (I) (Instr. 4)      Ownership
   of Month                             (Instr. 4)
  (Instr. 3
    and 4)
- ----------------------------------------------------------------------------
    <C>                <C>               <C>
- ----------------------------------------------------------------------------
 2,600,400              I                (1)
- ----------------------------------------------------------------------------
 2,600,400              I                (1)
- ----------------------------------------------------------------------------
 2,600,400              I                (1)
- ----------------------------------------------------------------------------
   240,000              D                (2)
- ----------------------------------------------------------------------------


</TABLE>

Reminder: Report on a separate line for each class of securities
beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, SEE
Instruction 4(b)(v).



                                                                       (Over)
                                                              SEC 1474 (7-96)
                                                                  Page 1 of 2

<PAGE>


FORM 4 (continued)

<TABLE>
<CAPTION>
TABLE II - DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
           (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)
- ----------------------------------------------------------------------------
1. Title of Derivative 2. Conver- 3. Transac- 4. Transac-  5. Number of
   Security (Instr. 3)    sion or    tion Date   tion Code    Derivative
                          Exercise   (Month/     (Instr. 8)   Securities
                          Price of    Day/     ------------   Acquired (A)
                          Deriv-      Year)      Code  V      or Disposed
                          ative                               of (D) (Instr.
                          Security                              3, 4, and 5)
                                                               -------------
                                                                (A)      (D)
- ----------------------------------------------------------------------------
          <S>              <C>         <C>       <C>  <C>       <C>      <C>
- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------



- ----------------------------------------------------------------------------
6. Date Exer-       7. Title and Amount  8. Price of
cisable and         of Underlying        Derivative
Expiration Date     Securities           Security
(Month/Day/         (Instr. 3 and 4)     (Instr. 5)
Year)               -------------------
- -----------------            Amount or
Date     Expira-      Title  Number of
Exer-    tion                Shares
cisable  Date
- ----------------------------------------------------------------------------
  <C>       <C>         <C>     <C>           <C>
- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------



- ----------------------------------------------------------------------------
9. Number of     10. Ownership     11. Nature of
   Derivative        Form of           Indirect
   Securities        Derivative        Beneficial
   Beneficially      Security:         Ownership
   Owned at          Direct (D) or     (Instr. 4)
   End of Month      Indirect (I)
   (Instr. 4)        (Instr. 4)
- ----------------------------------------------------------------------------
      <C>               <C>                <C>
- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------

- ----------------------------------------------------------------------------
</TABLE>

Explanation of Responses

(1)  The shares of Common Stock to which this note relates are held directly
by Oracle Partners, L.P. ("Oracle Partners") (1,390,500 shares), Oracle
Institutional Partners, L.P. ("Oracle Institutional") (441,700 shares), GSAM
Oracle Investments, Inc. ("GSAM Investments") (591,800 shares), Oracle
Offshore Limited ("Oracle Offshore") (91,400 shares), The Feinberg Family
Foundation (the "Foundation") (28,000 shares) and Oracle Management Company
Employee Retirement Account (the "Retirement Plan") (57,000 shares). Oracle
Investment Management, Inc. (the "Investment Manager") serves as investment
manager to and has investment discretion over the securities held by GSAM
Investments, Oracle Offshore and the Retirement Plan.  The undersigned is the
general partner of Oracle Partners and Oracle Institutional, the trustee of
the Foundation, and the sole shareholder and president of the Investment
Manager.  In accordance with Instruction 4(b)(iii), the entire number of
shares of Common Stock held by Oracle Partners, Oracle Institutional, GSAM
Investments, Oracle Offshore, the Foundation and the Retirement Plan is
reported herein.  The undersigned disclaims any beneficial ownership of the
securities to which this Form 4 relates for purposes of Section 16 of the
Securities and Exchange Act of 1934, as amended, except as to such securities
representing the undersigned's pro rata interest in, and interest in the
profits of, Oracle Partners, Oracle Institutional, GSAM Investments, Oracle
Offshore, the Foundation and the Retirement Plan.

(2)  The 240,000 shares of Common Stock to which this note relates are held
directly by the undersigned.

(3)  The shares of Common Stock to which this note relates were acquired by
the Foundation (10,000 shares) and the Retirement Plan (20,000 shares).

(4)  The shares of Common Stock to which this note relates were acquired by
the Foundation (5,000 shares) and the Retirement Plan (10,000 shares).

(5)  The shares of Common Stock to which this note relates were acquired by
Oracle Partners (2,100 shares), Oracle Institutional (600 shares), GSAM
Investments(600 shares) and Oracle Offshore (100 shares).

**Intentional misstatements or omissions of facts constitute Federal Criminal
Violations.  SEE 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this form, one of which must be manually signed.
If space is insufficient, SEE Instruction 6 for procedure.


                              /s/ Larry N. Feinberg                1/10/00
                              --------------------------------     --------
                              **Signature of Reporting Person        Date

                                                                Page 2 of 2



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