MERRILL LYNCH VARIABLE SERIES FUNDS INC
497, 2000-10-27
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                    MERRILL LYNCH VARIABLE SERIES FUNDS, INC.
                                 PRIME BOND FUND

                        Supplement dated October 27, 2000
                        to Prospectus dated April 4, 2000

         THE  FOLLOWING   INFORMATION   SUPERSEDES  AND  REPLACES  ANY  CONTRARY
INFORMATION  CONTAINED IN THE PROSPECTUS UNDER THE CAPTIONS "KEY  FACTS--MERRILL
LYNCH  PRIME  BOND FUND AT A  GLANCE",  "DETAILS  ABOUT THE  FUND--HOW  THE FUND
INVESTS" AND "DETAILS ABOUT THE FUND--INVESTMENT STRATEGIES":

     Effective immediately, under normal circumstances, the Prime Bond Fund will
invest at least 65% of its assets in  fixed-income  securities of any kind rated
investment grade by a Nationally Recognized Statistical Rating Organization. The
Prime Bond Fund may invest up to 35% of its  assets in  fixed-income  securities
rated  below  investment  grade  by S&P or  Moody's  or  unrated  securities  of
equivalent  credit quality  ("junk  bonds");  however,  as a matter of operating
policy,  the Prime Bond Fund will not invest more than 10% of its assets in such
securities.

         Although  junk bonds  generally  have higher  yields than  fixed-income
securities with higher credit ratings,  they are high risk  investments that may
not pay interest or return principal as scheduled. Junk bonds generally are less
liquid and  experience  more price  volatility  than higher  rated  fixed-income
securities.

         Effective  immediately,  the Prime Bond Fund may engage in transactions
in certain derivatives,  such as financial futures contracts,  options and swaps
for hedging purposes or to enhance income. Derivatives allow the Prime Bond Fund
to increase or decrease  its risk  exposure  more quickly and  efficiently  than
other types of instruments.  Derivatives may be volatile and involve significant
risks, including credit, leverage and liquidity risks.



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