MERRILL LYNCH VARIABLE SERIES FUNDS INC
497, 2000-11-20
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                    MERRILL LYNCH VARIABLE SERIES FUNDS, INC.
                                 PRIME BOND FUND

                       Supplement dated November 20, 2000
                        to Prospectus dated April 4, 2000

         The  following   information   supersedes  and  replaces  any  contrary
information  contained in the Prospectus under the captions "Key  Facts--Merrill
Lynch  Prime  Bond Fund at a  Glance",  "Details  About the  Fund--How  the Fund
Invests" and "Details About the Fund--Investment Strategies":

         Effective immediately, under normal circumstances,  the Prime Bond Fund
will invest at least 65% of its assets in  fixed-income  securities  of any kind
rated  investment   grade  by  a  Nationally   Recognized   Statistical   Rating
Organization  ("NRSRO").  The Prime Bond Fund may invest up to 35% of its assets
in fixed-income  securities  rated below  investment grade by a NRSRO or unrated
securities of equivalent credit quality ("junk bonds");  however, as a matter of
operating  policy,  the Prime  Bond Fund  will not  invest  more than 10% of its
assets in such securities.

         Although  junk bonds  generally  have higher  yields than  fixed-income
securities with higher credit ratings,  they are high risk  investments that may
not pay interest or return principal as scheduled. Junk bonds generally are less
liquid and  experience  more price  volatility  than higher  rated  fixed-income
securities.

         Effective  immediately,  the Prime Bond Fund may engage in transactions
in certain derivatives,  such as financial futures contracts,  options and swaps
for hedging purposes or to enhance income. Derivatives allow the Prime Bond Fund
to increase or decrease  its risk  exposure  more quickly and  efficiently  than
other types of instruments.  Derivatives may be volatile and involve significant
risks, including credit, leverage and liquidity risks.


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