MERRILL LYNCH VARIABLE SERIES FUNDS INC
497, 2001-01-10
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                    MERRILL LYNCH VARIABLE SERIES FUNDS, INC.

                     Supplement dated January 8, 2001 to the
             Statement of Additional Information dated June 29, 2000


         Effective today, the American  Balanced Fund, the Global Strategy Focus
Fund and the  Quality  Equity  Fund may invest in  Standard & Poor's  Depositary
Receipts  ("SPDRs").  SPDRs are units of  beneficial  interest in an  investment
trust  sponsored by a wholly-owned  subsidiary of the American  Stock  Exchange,
Inc. (the "Exchange")  which represent  proportionate  undivided  interests in a
portfolio of securities consisting of substantially all of the common stocks, in
substantially  the same  weighting,  as the  component  stocks of the Standard &
Poor's 500 Stock Index (the "S&P 500  Index").  SPDRs are listed on the Exchange
and traded in the secondary market on a per-SPDR basis.

         SPDRs  are  designed  to  provide  investment  results  that  generally
correspond to the price and yield  performance of the component common stocks of
the S&P 500 Index.  The value of SPDRs is subject to change as the values of its
component  common stocks  fluctuate  according to the  volatility of the market.
Investments in SPDRs involve certain  inherent risks  generally  associated with
investments in a broadly based  portfolio of common  stocks,  including the risk
that the general level of stock prices may decline,  thereby adversely affecting
the  value  of each  unit of SPDRs  invested  in by a Fund.  Moreover,  a Fund's
investment in SPDRs may not exactly match the performance of a direct investment
in the  component  common  stocks  of  the  S&P  500  Index.  Additionally,  the
investment  trust may not fully  replicate the  performance of the S&P 500 Index
due to the temporary unavailability of certain index securities in the secondary
market  or due to  other  extraordinary  circumstances,  such  as  discrepancies
between the investment trust and the S&P 500 Index with respect to the weighting
of securities or the number of, for example,  larger  capitalized stocks held by
the S&P 500 Index and the investment trust.



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