GENOME THERAPEUTICS CORP
S-8, 1996-11-12
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                    Registration No. 333-_____

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                            GENOME THERAPEUTICS CORP.
               (Exact name of issuer as specified in its charter)

 MASSACHUSETTS                                          04-2297484
(State or other jurisdiction of                     (I.R.S. Employer
incorporation or organization)                     Identification No.)
                                100 Beaver Street
                          Waltham, Massachusetts 02154
           (Address of Principal Executive offices including zip code)

               1995 STOCK OPTION PLAN AND STOCK OPTION AGREEMENTS
                            (Full title of the Plan)
                                 Fenel M. Eloi
                            Genome Therapeutics Corp.
                                100 Beaver Street
                          Waltham, Massachusetts 02154
                     (Name and address of agent for service)

                                 (617) 893-5007
          (Telephone number, including area code, of agent for service)

                  Please send copies of all communications to:

                              David C. Chapin, Esq.
                                  Ropes & Gray
                             One International Place
                        Boston, Massachusetts 02110-2624
                            Telephone: (617) 951-7371
<TABLE>
<CAPTION>
<S>                       <C>                      <C>                   <C>                    <C>

                                                    Proposed              Proposed
Title of                                            Maximum               Maximum
Securities                 Amount                   Offering              Aggregate              Amount of
To Be                      To Be                    Price Per             Offering               Registration
Registered                 Registered               Share <F1>             Price <F1>              Fee


Common Stock,              1,730,000                $8.188                $14,165,240            $4,292.49
$.10 par value.
- -------------------------
<FN>

<F1> Estimated  solely for the purpose of calculating the registration fee on the
basis of the average  high and low prices of the Common Stock as reported by the
National  Association  of  Securities  Dealers  Automated  Quotation  System  on
November 11, 1996. Exhibit Index can be found on page 8.
</FN>
</TABLE>

                           This is page 1 of 22 pages.

                                       -1-



<PAGE>



                                     Part II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  Incorporation of Certain Documents by Reference

        The  Company's  Annual  Report on Form 10-K for the  fiscal  year  ended
August 31, 1995,  the Company's  amended  Annual Report on Form 10-K/A-3 for the
fiscal year ended August 31, 1995, the Company's  Quarterly  Report on Form 10-Q
for the quarter ended November 25, 1995, the Company's amended Quarterly Report
on Form 10-Q/A for the quarter ended November 25, 1996, the Company's  Quarterly
Report on Form 10-Q for the quarter ended February 24, 1996, the Company's 
amended Quarterly Report on Form 10-Q/A for the quarter ended February 24, 1996,
the Company's Quarterly Report on Form 10-Q for the  quarter  ended
May 25,  1996,  all the reports  filed by the Company with the Securities and
Exchange  Commission pursuant to Sections 13(a) and (c), 14 and 15(d) of the
Securities  Exchange Act of 1934 since the end of the fiscal year covered by the
Company's  Annual Report  referred to above,  and the  description of the
Company's  Common Stock contained in its Form 10/A, File No. 0-10824 are  
incorporated by reference and made a part of this  registration statement.

        All  reports  and  other  documents  subsequently  filed by the  Company
pursuant to Sections 13(a) and (c), 14 and 15(d) of the Securities  Exchange Act
of 1934, as amended,  prior to the filing of a  post-effective  amendment  which
indicates that all securities offered hereby have been sold or which deregisters
all securities remaining unsold, shall be deemed to be incorporated by reference
herein and to be a part hereof  from the date of the filing of such  reports and
documents.

Item 4.  Description of Securities

           Not Required.

Item 5.  Interests of Named Experts and Counsel

           Not Applicable.


Item 6.  Indemnification of Directors and Officers

        The  Company  is  organized  under  the  laws  of  The  Commonwealth  of
Massachusetts.   The  Massachusetts   Business  Corporation  Law  provides  that
indemnification of directors,  officers,  employees, and other agents of another
organization,  or who serve at its request is any  capacity  with respect to any
employee  benefit plan, may be provided by the  corporation  to whatever  extent
specified in its charter documents or votes adopted by its shareholders,  except
that no  indemnification  may be  provided  for any person  with  respect to any
matter as to which the person shall have been  adjudicated in any proceeding not
to have acted in good faith in the reasonable  belief that his action was in the
best interest of the  corporation.  Under  Massachusetts  law, a corporation can
purchase and maintain  insurance on behalf of any person  against any  liability
incurred as a  director,  officer,  employee,  agent,  or person  serving at the
request of the corporation as a director,  officer,  employee, or other agent of
another  organization  or with  respect to any  employee  benefit  plan,  in his
capacity  as such,  whether  or not the  corporation  would have power to itself
indemnify him against such liability.


                                       -2-
                                                      

<PAGE>



        The Company's Articles of Organization  provide that its directors shall
not be liable to the Company or its stockholders for monetary damages for breach
of fiduciary duty as a director,  except to the extent that the exculpation from
liabilities is not permitted under the Massachusetts Business Corporation Law as
in effect at the time such liability is determined. The By-Laws provide that the
Company shall indemnify its directors and officers to the full extent  permitted
by the laws of The Commonwealth of Massachusetts. In addition, the Company holds
a Directors and Officer Liability and Corporate Indemnification Policy.

Item 7.  Exemption from Registration Claimed

        Not Applicable.

Item 8.        Exhibits.

Exhibit 4(a).                       The Company's 1995 Stock Option Plan.

Exhibit 4(b).                       Form of Stock Option Agreements and Schedule
                                    of Agreements.

Exhibit 4(c).                       The Company's Restated Articles of Organi-
                                    zation (filed as an exhibit to the Company's
                                    Registration Statement on Form S-1
                                    (No. 2-75230) and incorporated herein by
                                    reference).

Exhibit 4(d).                       Amendment  dated  January  5, 1982 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Quarterly Report
                                    on Form 10-Q for the quarter ended  February
                                    27,   1982  and   incorporated   herein   by
                                    reference).

Exhibit 4(e).                       Amendment  dated  January 24, 1983 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Quarterly Report
                                    on Form 10-Q for the quarter ended  February
                                    26,   1983  and   incorporated   herein   by
                                    reference).

Exhibit 4(f).                       Amendment  dated  January 17, 1984 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Quarterly Report
                                    on Form 10-Q for the quarter ended  February
                                    25,   1984  and   incorporated   herein   by
                                    reference).

Exhibit 4(g).                       Amendment  dated  December 9, 1987 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Quarterly Report
                                    on Form 10-Q for the quarter ended  November
                                    28,   1987  and   incorporated   herein   by
                                    reference).

Exhibit 4(h).                       Amendment  dated  January 24, 1994 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Annual Report on
                                    Form 10-K for the year ended August 31, 1994
                                    and incorporated herein by reference).

                                       -3-


                                                       

<PAGE>



Exhibit 4(i).                       Amendment  dated  August 31,  1994 to
                                    Restated Articles of Organization  (filed as
                                    an exhibit to the Company's Annual Report on
                                    Form 10-K for the year ended August 31, 1994
                                    and incorporated herein by reference).

Exhibit 4(j).                       The Company's By-laws (filed as an exhibit
                                    to the Company's Registration Statement on
                                    Form S-1 (No. 2-75230) and incorporated
                                    herein by reference).

Exhibit 4(k).                       Amendment  dated  October 20, 1987 to
                                    the  By-laws  (filed  as an  exhibit  to the
                                    Company's Annual Report on Form 10-K for the
                                    fiscal  year  ended   August  31,  1987  and
                                    incorporated herein by reference).

Exhibit 4(l).                       Amendment  dated  October 16, 1989 to
                                    the  By-laws  (filed  as an  exhibit  to the
                                    Company's Annual Report on Form 10-K for the
                                    fiscal  year  ended   August  31,  1989  and
                                    incorporated herein by reference).

Exhibit 5.                          Opinion of Ropes & Gray.

Exhibit 23(a).                      Consent of Ropes & Gray (contained in
                                    Exhibit 5).

Exhibit 23(b).                      Consent of Arthur Andersen LLP.

Exhibit 24.                         Power of Attorney  (included as part of
                                    the  signature  pages  to this  Registration
                                    Statement).

Item 9.  Undertakings.

        (a)  The undersigned registrant hereby undertakes:

               (1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

                     (i)   To include any prospectus required by Section
        10(a)(3) of the Securities Act of 1933;

                     (ii) To  reflect  in the  prospectus  any  facts or  events
        arising after the effective date of the  registration  statement (or the
        most recent post-effective amendment thereof) which,  individually or in
        the aggregate,  represent a fundamental  change in the  information  set
        forth in the registration statement;

                     (iii) To include any material  information  with respect to
        the plan of distribution  not previously  disclosed in the  registration
        statement or any material change to such information in the registration
        statement;


                                       -4-
                                                        

<PAGE>



provided,  however,  that paragraphs  (a)(1)(i) and (a)(1)(ii) will not apply if
the information  required to be included in a post-effective  amendment by those
paragraphs  is  contained  in periodic  reports  filed with or  furnished to the
Commission  by the  registrant  pursuant  to Section 13 or Section  15(d) of the
Securities  Exchange  Act of 1934  that are  incorporated  by  reference  in the
registration statement.

               (2) That, for the purpose of determining  any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

               (3) To  remove  from  registration  by means of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

        (b) The undersigned  registrant  hereby undertakes that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934 (and,  where  applicable,  each  filing of any
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

        (c)  Insofar  as  indemnification  for  liabilities  arising  under  the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the registrant  pursuant to the foregoing  provisions,  or otherwise,
the  registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.


                                       -5-


                                                         

<PAGE>



                                   SIGNATURES

        Pursuant  to  the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Waltham,  Commonwealth of Massachusetts,  on this 1st
day of November, 1996.

                                                    Genome Therapeutics Corp.

                                                    By:/s/Fenel M. Eloi
                                                    -------------------------
                                                    Title: Vice President,
                                                           Treasurer and
                                                           Chief Financial
                                                           Officer


        KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints Robert J. Hennessey and Fenel M. Eloi and each of
them,  with  full  power  to  act  without  the  other,   his  true  and  lawful
attorneys-in-fact and agent, with full power of substitution and resubstitution,
for him and in his name,  place and stead, in any and all capacities to sign any
or all  amendments  to this  registration  statement,  including  post-effective
amendments,  and to file the same with all exhibits thereto, and other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto said attorneys-in-fact and agents and each of them full power and authority
to do and perform  each and every act and thing  requisite  and  necessary to be
done in and about the premises, as fully to all intents and purposes as he might
or  could  do  in  person,   hereby  ratifying  and  confirming  all  that  said
attorneys-in-fact  and agents or any substitutes lawfully do or cause to be done
by virtue hereof.

        Pursuant  to the  requirements  of the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

    Name                       Title                             Date

/s/ Robert J. Hennessey        Chairman of the Board;         November 1, 1996
- --------------------------     President and Chief
Robert J. Hennessey            Executive Officer (Principal
                               Executive Officer)


/s/ Orrie M. Friedman          Director                       November 1, 1996
- -------------------------
Orrie M. Friedman




/s/ Lawrence Levy              Director                       November 1, 1996
Lawrence Levy



/s/ Donald J. McCarren         Director                       November 1, 1996
- ----------------------------
Donald J. McCarren



                                       -6-



<PAGE>


    Name                       Title                             Date


/s/ Steven M. Rauscher         Director                       November 1, 1996
- ------------------------------
Steven M. Rausher



/s/ Philip Leder               Director                       November 1, 1996
- ------------------------------
Philip Leder



/s/ Fenel M. Eloi              Vice President; Treasurer and  November 1, 1996
- ------------------------------ Chief Financial Officer
Fenel M. Eloi                  (Principal Financial and
                               Accounting Officer)





                                       -7-



<PAGE>
<TABLE>
<CAPTION>
<S>               <C>                                                                            <C>



                                                        EXHIBIT INDEX

Number                                               Title of Exhibit                             Page

4(a).              The Company's 1995 Stock Option Plan                                             9

4(b).              Form of Stock Option Agreements and Schedule                                     15
                   of Agreements

5.                 Opinion of Ropes & Gray                                                          20

23(a).             Consent of Ropes & Gray                                              Contained in Exhibit 5

23(b).             Consent of Arthur Andersen LLP                                                   22

24.                Power of Attorney                                                    Included as Part of Signature
                                                                                        Pages to this Registration

                                       -8-

</TABLE>


<PAGE>




                                                                   EXHIBIT 4(A)

                            GENOME THERAPEUTICS CORP.

                             1995 STOCK OPTION PLAN

1.   PURPOSE

    The  purpose of the 1995 Stock  Option  Plan (the  "Plan") is to advance the
interests of Genome  Therapeutics Corp. (the "Company") by enhancing the ability
of the Company and its subsidiaries to attract and retain employees, consultants
or  advisers  who are in a position  to make  significant  contributions  to the
success of the Company; to reward such individuals for their contributions;  and
to encourage such  individuals  to take into account the long-term  interests on
the Company through interests in shares of the Company's common stock ("Stock").
Any employee,  consultant or adviser  designated to  participate  in the Plan is
referred to as a  "participant."  The proceeds  received  from the sale of stock
pursuant to the Plan shall be used for general corporate purposes.

    Options  granted  pursuant  to the Plan may be  incentive  stock  options as
defined in Section 422 of the Code (any option that is intended so to qualify as
an incentive stock option being referred to herein as an "incentive option"), or
options that are not incentive options,  or both. Except as otherwise  expressly
provided with respect to an option grant, no option granted pursuant to the Plan
shall be an incentive option.

2.   ADMINISTRATION

    The Plan shall be administered by a Stock Option Committee  appointed by, or
in a manner  authorized  by, the Board of Directors (the "Board") of the Company
or such  other  committee  of the  Board as the  Board  shall  from time to time
appoint or authorize to administer the Plan (the Stock Option  Committee or such
other committee being hereinafter referred to as the "Committee"). The Committee
shall have authority, not inconsistent with the express provisions for the Plan,
(a) to grant awards consisting of options or stock appreciation rights ("SARs"),
or both, to such participants as the Committee may select;  (b) to determine the
time or times when  awards  shall be  granted  and the number of shares of Stock
subject to each award; (c) to determine which options are, and which options are
not, incentive options; (d) to determine the terms and conditions of each award;
(e) to prescribe the form or forms of any instruments  evidencing awards and any
other instruments  required under the Plan and to change such forms from time to
time;  (f)  to  adopt,   amend  and  rescind  rules  and   regulations  for  the
administration  of the Plan;  and (g) to  interpret  the Plan and to decide  any
questions and settle all controversies and disputes that may arise in connection
with the Plan.  Such  determinations  of the Committee  shall be conclusive  and
shall bind all parties.  Subject to Section 8, the Committee shall also have the
authority,  both generally and in particular instances, to waive compliance by a
participant  with any obligation to be performed by him under an award, to waive
any condition or provision of an award, and to amend or cancel any award (and if
an award is canceled,  to grant a new award on such terms as the Committee shall
specify),  except that the  Committee may not take any action with respect to an
outstanding  award that  would  adversely  affect the rights of the  participant
under such award without such  participant's  consent.  Nothing in the preceding
sentence  shall  be  construed  as  limiting  the  power  of the  Board  to make
adjustments required by Section 4(c) and Section 6(j).

    The Committee  shall consist of two or more members of the Board who are, at
the  time of  their  appointment  and  any  time  they  exercise  discretion  in
administering the Plan, "disinterested persons" within the meaning of Rule 16b-3
under the Securities  Exchange Act of 1934, and "outside  directors"  within the
meaning of  sec.162(m)  of the Code. A majority of the members of the  Committee
shall constitute a quorum, and all determinations of the Committee shall be made
by a majority of its members.  Any determination of the Committee under the Plan
may be made without  notice or meeting of the Committee by a writing signed by a
majority of the Committee members.





                                       -9-



<PAGE>



3.   EFFECTIVE DATE AND TERM OF PLAN

    The Plan shall  become  effective on the date on which it is approved by the
shareholders  of the Company.  Grants of awards under the Plan may be made prior
to that date (but after Board adoption of the Plan),  subject to approval of the
Plan by such shareholders.

    No awards shall be granted under the Plan after the  completion of ten years
from the date on which the Plan was adopted by the Board, but awards  previously
granted may extend beyond that date.

4.   SHARES SUBJECT TO THE PLAN

    a. Number of Shares.  Subject to adjustment as provided in Section 4(c), the
aggregate  number of shares of Stock that may be delivered  upon the exercise of
awards  granted under the Plan shall be 750,000.  If any award granted under the
Plan  terminates  without  having been  exercised in full,  or upon  exercise is
satisfied  other than by delivery of Stock,  the number of shares of Stock as to
which such award was not  exercised  shall be available for future grants within
the limits set forth in this Section 4(a).

    b. Maximum Shares.  Subject to Section 4(d), the maximum number of shares of
Stock with  respect to which an award may be granted to any  participant  during
any single  fiscal year is 500,000.  For purposes of this  paragraph,  except as
otherwise  provided in regulations or other guidance issued under Section 162(m)
of the Code,  any  repricing of an option or Stock  Appreciation  Right shall be
treated as an additional grant.

    c. Shares to be Delivered.  Shares  delivered  under the Plan will be common
stock of the Company and shall be  authorized  but  unissued  Stock,  or, if the
Board so decides in its sole discretion, previously issued Stock acquired by the
Company  and  held in its  treasury.  No  fractional  shares  of  Stock  will be
delivered under the Plan.

    d. Changes in Stock. In the event of a stock dividend or other  distribution
to common  stock  holders  other than a normal  cash  dividend,  stock  split or
combination of shares, recapitalization or other change in the Company's capital
stock,  the  number  and kind of shares of stock or  securities  of the  Company
subject to awards then  outstanding or subsequently  granted under the Plan, the
exercise price of such awards,  the maximum number of shares or securities  that
may be  delivered  under  the  Plan,  and  other  relevant  provisions  shall be
appropriately adjusted by the Board, whose determination shall be binding on all
persons.

    The Board or  Committee  may also  adjust  the  number of shares  subject to
outstanding  awards,  the exercise price of outstanding  awards and the terms of
outstanding  awards, to take into  consideration  material changes in accounting
practices or  principles,  extraordinary  dividends,  consolidations  or mergers
(except those described in Section 6(j)),  acquisitions or dispositions of stock
or property or any other event if it is  determined by the Board or Committee in
its sole discretion  that such adjustment is appropriate to avoid  distortion in
the operation of the Plan, provided that no such adjustment shall be made in the
case of an incentive option, without the consent of the participant, if it would
constitute a modification, extension or renewal of the option within the meaning
of section 424(h) of the Code.

5.   ELIGIBILITY FOR AWARDS

    Those  eligible to receive  awards under the Plan  ("Participants")  will be
employees  of the  Company or any of its  subsidiaries  ("Employees")  and other
persons or entities (including without limitation  non-Employee directors of the
Company or a subsidiary  of the Company)  who, in the opinion of the  Committee,
are in a  position  to make a  significant  contribution  to the  success of the
Company  and its  subsidiaries.  Incentive  options  shall  be  granted  only to
"employees" as defined in the  provisions of the Code or regulations  thereunder
applicable to incentive stock options.

    A subsidiary  for purposes of the Plan shall be a  corporation  (i) in which
the Company owns,  directly or indirectly,  stock  possessing 50% or more of the
total  combined  voting  power of all  classes  of stock or (ii) over  which the
Company has effective operating control; provided,  however, that no corporation
shall be deemed a subsidiary for the purpose of any

                                      -10-



<PAGE>



provisions  applicable to incentive  options,  and no incentive options shall be
granted to employees of such  corporation,  unless in each case such corporation
shall constitute a subsidiary as defined in clause (i) above.

6.   TERMS AND CONDITIONS OF OPTIONS AND SARs

    a.  Exercise  Price of Options.  The exercise  price of each option shall be
determined by the Committee but in the case of an incentive  option shall not be
less  than  100%  (110%,  in  the  case  of an  incentive  option  granted  to a
ten-percent  shareholder)  of the fair market value of the Stock at the time the
option  is  granted;  nor shall the  exercise  price be less,  in the case of an
original  issue of authorized  stock,  than par value.  For this purpose,  "fair
market value" in the case of incentive options shall have the same meaning as it
does in the provisions of the Code and the regulations  thereunder applicable to
incentive options; and "ten-percent  shareholder" shall mean any participant who
at the time of grant owns directly,  or by reason of the  attribution  rules set
forth in section 424(d) of the Code is deemed to own, stock possessing more than
10% of the total combined voting power of all classes of stock of the Company or
of any of its parent or subsidiary corporations.

    b. Duration of Options. An option shall be exercisable during such period or
periods as the Committee may specify.  The latest date on which an option may be
exercised (the "Final Exercise Date") shall be the date which is ten years (five
years, in the case of an incentive option granted to a "ten-percent shareholder"
as defined in (a) above)  from the date the option was  granted or such  earlier
date as may be specified by the Committee at the time the option is granted.

c. Exercise of Options.

    i. An option  shall become  exercisable  at such time or times and upon such
conditions  as the  Committee  shall  specify.  In the  case  of an  option  not
immediately  exercisable in full,  the Committee may at any time  accelerate the
time at which all or any part of the option may be exercised.

    ii. Any  exercise  of an option  shall be in  writing,  signed by the proper
person and delivered or mailed to the Company, accompanied by (A) such documents
as may be required by the Committee  and (B) payment in full as specified  below
in Section 6(d) for the number of shares for which the option is exercised.

    iii. In the case of an option that is not an incentive option, the Committee
shall have the right to require that the participant exercising the option remit
to the Company an amount  sufficient  to satisfy any  federal,  state,  or local
withholding tax requirements (or make any other arrangements satisfactory to the
Company with regard to such taxes)  prior to the delivery of any Stock  pursuant
to the exercise of the option. If permitted by the Committee, either at the time
of the grant of the option or the time of exercise,  the  participant may elect,
at such time and in such manner as the Committee may prescribe,  to satisfy such
withholding  obligation  by (A)  delivering  to the Company  Stock owned by such
individual having a fair market value equal to such withholding  obligation,  or
(B)  requesting  that  the  Company  withhold  from  the  shares  of Stock to be
delivered  upon the  exercise a number of shares of Stock  having a fair  market
value equal to such withholding obligation.

    In the case of an incentive  option,  if at the time the option is exercised
the Committee  determines that under  applicable law and regulations the Company
could be liable for the  withholding of any federal or state tax with respect to
a disposition of the Stock received upon exercise,  the Committee may require as
a condition of exercise that the participant  exercising the option agree (A) to
inform the Company  promptly of any  disposition  (within the meaning of section
424(c)  of the Code and the  regulations  thereunder)  of  Stock  received  upon
exercise,  and (B) to give such security as the Committee deems adequate to meet
the  potential  liability  of the Company  for the  withholding  of tax,  and to
augment  such  security  from  time  to  time in any  amount  reasonably  deemed
necessary by the Committee to preserve the adequacy of such security.

    iv. If an option is exercised by the executor or administrator of a deceased
participant, or by the person or persons to whom the option has been transferred
by the participant's will or the applicable laws of descent and distribution,
the

                                      -11-



<PAGE>



Company shall be under no obligation to deliver Stock  pursuant to such exercise
until the  Company is  satisfied  as to the  authority  of the person or persons
exercising the option.

    d. Payment for and Delivery of Stock.  Stock  purchased  upon exercise of an
option under the Plan shall be paid for as follows:  (i) in cash or by certified
check or cashier's check,  bank draft or money order payable to the order of the
Company  or (ii) if so  permitted  by the  Committee  (which,  in the case of an
incentive  option,  shall  specify such method of payment at the time of grant),
(A) through the delivery of shares of Stock (duly owned by the  participant  and
for  which  the  participant  has good  title,  free and  clear of any liens and
encumbrances)  having a fair market value on the last business day preceding the
date  of  exercise  equal  to  the  purchase  price  or (B)  by  delivery  of an
unconditional and irrevocable undertaking by a broker to deliver promptly to the
Company  sufficient funds to pay the exercise price or (C) by any combination of
the permissible forms of payment.

    e. Stock Appreciation Rights. The Committee in its discretion may grant SARs
either in tandem with or independent of options  awarded under the Plan.  Except
as hereinafter  provided,  each SAR will entitle the participant to receive upon
exercise,  with  respect  to each share of Stock to which the SAR  relates,  the
excess of (i) the share's  value on the date of exercise,  over (ii) the share's
fair  market  value on the date it was  granted.  For  purposes  of clause  (i),
"value"  shall mean fair market value;  provided,  that the Committee may adjust
such value to take into  account  dividends on the Stock and may also grant SARs
that provide, in such limited circumstances following a change in control of the
Company (as  determined by the  Committee)  as the  Committee may specify,  that
"value"  for  purposes  of clause (i) is to be  determined  by  reference  to an
average value for the Stock during a period immediately  preceding the change in
control, all as determined by the Committee. The amount payable to a participant
upon  exercise of an SAR shall be paid either in cash or in shares of Stock,  as
the Committee  determines.  Each SAR shall be exercisable  during such period or
periods  and on such  terms  as the  Committee  may  specify.  No SAR  shall  be
exercisable after the date which is ten years from the date of grant.

    f. Delivery of Stock.  A participant shall not have the rights of a 
shareholder with regard to awards under the Plan except as to Stock actually
received by him under the Plan.

    The Company shall not be obligated to deliver any shares of Stock (i) until,
in the opinion of the Company's  counsel,  all applicable federal and state laws
and regulations have been complied with, (ii) if the outstanding Stock is at the
time listed on any stock  exchange,  until the shares to be delivered  have been
listed or  authorized  to be listed on such  exchange  upon  official  notice of
issuance,  and (iii)  until all  other  legal  matters  in  connection  with the
issuance  and  delivery  of such  shares  have been  approved  by the  Company's
counsel.  If the sale of Stock has not been registered  under the Securities Act
of 1933, as amended,  the Company may require, as a condition to exercise of the
award, such  representation or agreements as counsel of the Company may consider
appropriate to avoid violation of such Act and may require that the certificates
evidencing such Stock bear an appropriate legend restricting transfer.

    g. Nontransferability of Awards. Except as the Board may otherwise determine
in connection with the gifts, no award may be transferred  other than by will or
by the laws of descent and distribution, and during a participant's lifetime, an
award  may be  exercised  only  by him  (or in the  event  of the  participant's
incapacity,  the person or persons legally appointed to act on the participant's
behalf).

    h.  Death.  If a  participant  dies,  each  award  held  by the  participant
immediately  prior to death may be exercised,  to the extent it was  exercisable
immediately prior to death, by his executor or  administrator,  or by the person
or persons to whom the award is transferred  by will or the  applicable  laws of
descent and  distribution,  at any time within the three-year period ending with
the third  anniversary  of the  participant's  death (or such  shorter or longer
period as the Board or Committee may determine) but in no event beyond the Final
Exercise Date. All awards held by a participant  immediately prior to death that
are not then exercisable shall terminate on the date of death.

    i. Other Termination of Service.  If an employee's employment with the
Company and its subsidiaries terminates for any reason other than death, all
awards held by the employee that are not then exercisable on the date employment
terminates shall continue to be exercisable for a period of three months (or 
such longer period as the Committee may

                                      -12-



<PAGE>



determine,  but in no event beyond the Final  Exercise Date) unless the employee
was  discharged  for cause  which in the  opinion  of the  Committee  casts such
discredit on him as to justify  termination of his awards.  After  completion of
that  three-month  period  (or such  shorter  or  longer  period as the Board or
Committee  may  determine)  such  awards  shall  terminate  to  the  extent  not
previously exercised,  expired or terminated. For purposes of this Section 6(i),
employment  shall not be considered  terminated (i) in the case of sick leave or
other  bona fide  leave of  absence  approved  for  purposes  of the Plan by the
Committee,  so long as the employee's right to reemployment is guaranteed either
by  statute or by  contract,  or (ii) in the case of a  transfer  of  employment
between  the  Company  and a  subsidiary  or  between  subsidiaries,  or to  the
employment  of a  corporation  (or a parent or  subsidiary  corporation  of such
corporation)  issuing or assuming  an award in a  transaction  to which  section
424(a) of the Code applies.

    In the case of a participant who is not an employee,  provisions relating to
the exercisability of awards following termination of service shall be specified
in the award. If not so specified,  all awards held by such participant that are
not then exercisable shall terminate upon termination of service.

    j.  Mergers,  etc.  In the event of a  consolidation  or merger in which the
Company is not the surviving  corporation or which results in the acquisition of
substantially  all the Company's  outstanding Stock by a single person or entity
or by a group of persons and/or entities  acting in concert,  or in the event of
the sale or transfer of substantially all the Company's assets,  all outstanding
awards shall  thereupon  terminate,  provided that at least 20 days prior to the
effective date of any such merger, consolidation or sale of assets, the Board or
Committee shall either (i) make all outstanding awards  exercisable  immediately
prior to consummation of such merger, consolidation or sale of assets or (ii) if
there is a surviving or acquiring corporation,  arrange, subject to consummation
of the merger,  consolidation or sale of assets,  to have that corporation or an
affiliate of that corporation grant to participants  replacement awards which in
the case of  incentive  awards  satisfy,  in the  determination  of the Board or
Committee, the requirement of section 424(a) of the Code.

    The Board or Committee may grant awards under the Plan in  substitution  for
awards held by employees,  consultants  or advisers of another  corporation  who
concurrently  becomes  employees,  consultants  or  advisers of the Company or a
subsidiary  of the  Company  as a result  of a merger or  consolidation  of that
corporation with the Company or a subsidiary of the Company, or as the result of
the  acquisition  by the Company or a  subsidiary  of the Company of property or
stock of that  corporation.  The Company may direct  that  substitute  awards be
granted  on such  terms  and  conditions  as the  Board or  Committee  considers
appropriate in the circumstances.

7.   EMPLOYMENT RIGHTS

    Neither the  adoption of the Plan nor the grant of awards  shall confer upon
any  participant  any right to  continue  as an employee  of, or  consultant  or
adviser  to, the  Company or any parent or  subsidiary  or affect in any way the
right of the Company or parent or subsidiary to terminate  such  participant  at
any time.  Except as  specifically  provided by the Committee in any  particular
case, the loss of existing or potential profit in awards granted under this Plan
shall not  constitute an element of damages in the event of  termination  of the
relationship  of a  participant  even if the  termination  is in violation of an
obligation of the Company to the participant by contract or otherwise.

8.   EFFECT, DISCONTINUANCE, CANCELLATION, AMENDMENT AND TERMINATION

    Neither adoption of the Plan nor the grant of awards to a participant  shall
affect  the  Company's  right to make  awards to such  participant  that are not
subject to the Plan, to issue to such participant Stock as a bonus or otherwise,
or to adopt other plans or arrangements under which Stock may be issued.

    The Committee may at any time  discontinue  granting  awards under the Plan.
With the consent of the  participant,  the  Committee  may at any time cancel an
existing  award in whole or in part and grant  another  award for such number of
shares as the Committee specified.  The Board may at any time or times amend the
Plan or any outstanding  award for the purpose of satisfying the requirements of
section 422 of the Code or of any changes in applicable  laws or  regulations or
for any other  purpose  that may at the time be  permitted by law, or may at any
time terminate the Plan as to any further

                                      -13-

<PAGE>



grants of awards,  provided  that  (except to the extent  expressly  required or
permitted  by the Plan) no such  amendment  shall,  without the  approval of the
stockholders of the Company  effectuate a change for which stockholder  approval
is required in order for the Plan to continue to qualify  under Rule 16b-3 under
the  Securities  Exchange  Act of 1934 or Section  422 of the Code,  and no such
amendment  shall  adversely  affect the rights of any  participant  (without his
consent) under any award previously granted.


                                      -14-



<PAGE>





                                                                   EXHIBIT 4(b)

                            GENOME THERAPEUTICS CORP.

                             STOCK OPTION AGREEMENT

                             (Non-Statutory Option)


Non-Statutory Stock Option granted by Genome Therapeutics Corp., a Massachusetts
corporation  (the  "Company"),  to  [Optionee],  a director of the Company  (the
"Optionee").

         1.  Grant of Option

This agreement evidences the grant by the Company to the Optionee of an option 
to purchase, on the terms provided herein, a total of ______ shares of the
Company's Common Stock, $.10 par value ("Common Stock"), at a price of $____ per
share.  This option does not constitute an incentive stock option within the
meaning of Section 422A of the Internal Revenue Code.  This option shall
terminate on November 16, 2005, and is subject to earlier termination as
provided in Sections 5 and 6 below.  Subject to the other terms hereof, this
option is exercisable as follows:  as to ______ if the average closing price of
the Common Stock is, for a period of ten (10) out of twenty (20) consecutive
trading days, $_____ or higher, as reported on the NASDAQ National
Market ("NASDAQ") (or such principal securities exchange as the Common Stock
may be traded; and as to an additional ______ shares if the average closing 
price of the Common Stock is, for a period of ten (10) out of twenty (20)
consecutive trading days, $_____ or higher, as reported on NASDAQ (or such
principal securities exchange as the Common Stock may be traded..

         2.  Exercise of Option

Each  election  to  exercise  this  option  shall be in  writing,  signed by the
Optionee or by his  executor or  administrator  or the person or persons to whom
this  option  is  transferred  by will or the  applicable  laws of  descent  and
distribution  (the "Legal  Representative"),  and received by the Company at its
principal  office in Waltham,  Massachusetts,  accompanied by this agreement and
payment  in full as  provided  in  Section 3 below.  In the event the  option is
exercised by such Legal Representative, the Company shall be under no obligation
to deliver stock  hereunder  unless and until the Company is satisfied  that the
person or persons exercising the option is or are the duly appointed executor or
administrator  of the  deceased  Optionee  or the person or persons to whom this
option has been  transferred  by Optionee's  will or by the  applicable  laws of
descent and distribution.

         3.  Payment for Stock


                                      -15-



<PAGE>



Shares  shall be issued only upon  receipt by the Company of full payment of the
purchase price for the shares as to which the option is exercised.  The purchase
price  is  payable  by the  Optionee  to the  Company  either  (i) in cash or by
certified check or cashier's check payable to the order of the Company;  or (ii)
through the  delivery of shares of Common  Stock (duly owned by the Optionee and
as to  which  the  Optionee  has good  title  free and  clear of any  liens  and
encumbrances)  having  a fair  market  value  (as  determined  by the  Board  of
Directors of the Company) equal to the purchase price; or (iii) by a combination
of cash and Common Stock as provided above. The Company will not be obligated to
deliver any shares unless and until,  in the opinion of the  Company's  counsel,
all applicable  federal and state laws and regulations  have been complied with,
nor, in the event the  outstanding  common  stock is at the time listed upon any
stock exchange,  unless and until the shares to be delivered have been listed or
authorized  to be added to the list upon  official  notice of legal  matters  in
connection  with the issuance  and delivery of shares have been  approved by the
Company's counsel. Without limiting the generality of the foregoing, the Company
may require from the Optionee such investment  representation or such agreement,
if any, as counsel for the Company  may  consider  necessary  in order to comply
with the  Securities  Act of 1933,  as amended and may require that the Optionee
agree  that he will  notify the  Company  when he makes any  disposition  of the
shares whether by sale, gift or otherwise. The Company will use its best efforts
to effect any such compliance or listing,  and the Optionee will take any action
reasonably  requested by the Company in such connection.  The Optionee will have
the rights of a  shareholder  only as to shares  actually  acquired  by him upon
exercise of the option granted hereby.

         4.  Non-transferability of Option

This option may not be transferred by the Optionee  otherwise than by will or by
the laws of descent and  distribution;  and during the Optionee's  lifetime this
option may be exercised only by him.

         5.  Termination of Service as a Director

If the Optionee ceases to be a director of the Company for any reason other than
his death, he may thereafter  exercise this option to the extent he was entitled
to exercise it on the date when his service as a director  terminated,  but only
within three months after the date of such  termination  (unless a longer period
is allowed by the Board of Directors of the Company).  In no event, however, may
the  Optionee  exercise  this  option  at a time  when the  option  would not be
exercisable had the Optionee's service as a director continued.  For purposes of
this  provision,  the  Optionee's  service as a director  will not be considered
terminated in the case of a bona fide leave of absence  approved by the Board of
Directors of the Company.

         6.  Death

If the Optionee dies at a time when he is entitled to exercise this option, then
at any time or times within  three years after his death (or such longer  period
as the  Board  of  Directors  of the  Company  may  allow)  such  option  may be
exercised, as to all or any of the shares that the Optionee was

                                      -16-



<PAGE>



entitled  to  purchase  immediately  prior  to his  death,  by his  executor  or
administrator or the person or persons to whom the option is transferred by will
or the applicable laws of descent and  distribution,  and except as so exercised
such option will expire at the end of such  period.  In no event,  however,  may
this option be exercised after the termination of the option.

         7.  Administration

The  option  granted  by this  agreement  will be  administered  by the Board of
Directors  of the  Company  which  will have the  authority  to  interpret  this
agreement and to decide all questions and settle all  controversies  and dispute
which may arise in  connection  therewith.  All  decisions,  determinations  and
interpretations  of the  Board  of  Directors  will be  binding  on all  parties
concerned. A majority of the members of the Board of Directors will constitute a
quorum,  and all  determinations  of the  Board of  Directors  will be made by a
majority of its members.  Any determination of the Board of Directors under this
agreement  may be made without  notice or meeting of the Board of Directors by a
written  instrument  signed  by a  majority  of  the  members  of the  Board  of
Directors.

         8.  Stock to be Delivered

Stock to be delivered  upon exercised of this option will be common stock of the
Company and may constitute an original issue of authorized but unissued stock or
may consist of  previously  issued stock  acquired by the Company as  determined
from time to time by the Board of  Directors.  The  Board of  Directors  and the
proper  officers of the Company will take any  appropriate  action  required for
such delivery.

         9.  Changes in Stock

In  the  event  of  a  stock  dividend,   split-up  or  combination  of  shares,
recapitalization or merger in which the Company is the surviving corporation, or
other  similar  capital  change,  the  number  and  kind of  shares  of stock or
securities of the Company subject to the option granted hereby, the option price
and other relevant  provisions  will be  appropriately  adjusted by the Board of
Directors of the Company,  whose  determination will be binding on the Optionee.
In the  event of a  consolidation  or merger  in which  the  Company  is not the
surviving  corporation,  or in the event of complete liquidation of the Company,
the option  granted  hereby will  thereupon  terminate,  provided  that at least
twenty days prior to the effective date of any such consolidation or merger, the
Board of Directors  shall either (a) make the option granted hereby  immediately
exercisable,   or  (b)  arrange  to  have  the  surviving  corporation  grant  a
replacement option to the Optionee.

         10.  Amendments

The Board of  Directors of the Company may at any time or times amend the option
granted hereby for the purpose of satisfying the  requirements of any changes in
applicable laws or regulations or

                                      -17-



<PAGE>



for any other purpose  which may at the time be permitted by law,  provided that
(except to the extent  explicitly  required or  permitted  hereinabove)  no such
amendment will,  without the approval of the  stockholders  of the Company,  (a)
increase the number of shares  issuable upon exercise of the option,  (b) reduce
the exercise price of the option,  (c) extend the period within which the option
may be  exercised,  or (d) amend the  provisions of this Section 10, and no such
amendment will adversely affect the rights of the Optionee without his consent.

         11.  Governing Law

This  agreement  shall be  governed  by and  construed  in  accordance  with the
internal laws of The Commonwealth of Massachusetts.

         12.  Stockholder Approval

This agreement  shall not become  effective  unless and until the option granted
hereby is approved by the stockholders of the Company.

         IN WITNESS  WHEREOF,  the  Company  has  caused  this  agreement  to be
executed by its duly authorized  officer,  under its corporate seal. This option
is granted at the Company's office, on the date stated below.


                                                  GENOME THERAPEUTICS CORP.



                                                  By:___________________________
                                                     President


Date:  As of February 16, 1996

Accepted and Agreed:



- -----------------------------
[Optionee]

                                      -18-



<PAGE>

<TABLE>
<CAPTION>
<S>                <C>             <C>             <C>                <C>             <C>



                                           SCHEDULE OF STOCK OPTION AGREEMENTS


                    Price Per         Grant         Expiration         Shares           Exercise
Optionee            Share             Date          Date               Granted          Dates

Robert J.
Hennessey           $8.87           12/21/95        12/21/05            300000           <F1>

Philip Leder        $7.25           11/16/95        11/16/05             20000           <F2>

Lawrence Levy       $7.25           11/16/95        11/16/05             20000           <F2>

Donald J.
McCarren            $7.25           11/16/95        11/16/05             20000           <F2>


Steven  M.
Rauscher            $7.25           11/16/95        11/16/05             20000           <F2>

Bernd R.
Seizinger           $7.44            7/12/96         7/12/06            600000           <F3>
<FN>

<F1> The options are  exercisable  by their terms on December 21, 2000 or
earlier as follows:  (i) 75,000 options are  exercisable if the average closing
price of the Common Stock for a period of 10 out of 20 consecutive trading days
after the date of grant is $10.25 or higher;  (ii) an additional  100,000
options shall be exercisable if the average  closing price of the Common Stock
for a period of 10 out of 20  consecutive  trading days after the date of grant
is $12.25 or higher and (iii) an  additional  125,000  options shall be
exercisable  if the average closing  price of the  Common  Stock  for a period 
of 10 out of 20  consecutive trading days after the date of grant is $14.25 or
higher.

<F2> The options are  exercisable by their terms on November 16, 2000, or earlier
as follows:  (i) 50% of the options are exercisable if the average closing price
of the Common Stock for a period of 10 out of 20 consecutive  trading days after
the date of grant is $9.425 or higher; and (ii) an additional 50% of the options
shall be  exercisable  if the average  closing  price of the Common  Stock for a
period  of 10 out of 20  consecutive  trading  days  after  the date of grant is
$11.60 or higher.

<F3> The options are  exercisable by their terms as follows:  (i) an aggregate of
300,000 options are  exercisable  with respect to equal  installments  over four
years,   commencing  on  September  1,  1997;  (ii)  100,000  options  shall  be
exercisable  if the closing  price of the Common Stock for a period of 10 out of
20 consecutive  trading days after the date of grant is $14.25 or higher;  (iii)
100,000  options shall be  exercisable  if the closing price of the Common Stock
for a period of 10 out of 20 consecutive trading days after the date of grant is
$18.25 or higher; (iv) and the remaining 100,000 options shall be exercisable if
the closing  price of the Common Stock for a period of 10 out of 20  consecutive
trading days after the date of grant is $20.25 or higher.

                                      -19-
</FN>
</TABLE>




<PAGE>
















                                                                     EXHIBIT 5

                                                              November 12, 1996




Genome Therapeutics Corp.
100 Beaver Street
Waltham, Massachusetts  02154

Ladies and Gentlemen:

         We have acted as counsel for Genome Therapeutics Corp., a Massachusetts
corporation (the "Company") in connection with the preparation of a registration
statement on Form S-8 and all exhibits  thereto (the  "Registration  Statement")
filed with the  Securities and Exchange  Commission  under the Securities Act of
1933, as amended, for the registration of 1,730,000 shares of Common Stock, $.10
par value (the "Shares").

         Of the shares being  registered,  750,000  shares are issuable upon the
exercise of options  granted  pursuant to the  Company's  1995 Stock Option Plan
(the  "Plan") and  980,000 are  issuable  upon the  exercise of options  granted
pursuant to certain  stock  option  agreements  (the  "Agreements")  between the
Company and the respective holders.  The Company has informed us that the Shares
issuable  upon the  exercise  of  options  granted  under the  Agreements  may
be authorized but unissued shares or shares held from time to time in its
treasury.

         For  purposes  of  this  opinion,  we  have  examined  a  copy  of  the
Registration  Statement;  a copy of the  Plan;  copies  of the  Agreements;  the
Restated  Articles  of  Organization  of the  Company,  as amended to date;  the
By-laws of the Company,  as amended to date; the votes of the Board of Directors
and the  stockholders  of the Company  approving  and  adopting the Plan and the
Agreements;  and such  other  documents  and  records as we deem  necessary  for
purposes of this opinion.

         We have  assumed  that the Shares will be issued only  against  payment
therefor as provided in the Plan and the  Agreements and that the purchase price
for such shares

                                      -20-



<PAGE>



will not be less than the par value per share of the Company's  Common Stock. We
have also  assumed  that the  issuance of any such shares will not result in the
issuance by the Company of more than its authorized shares of Common Stock.

         Based upon and subject to the foregoing, we are of the opinion that:

         1.       The Company is a duly organized and validly existing
corporation under the laws of The Commonwealth of Massachusetts.

         2. The Shares,  when issued and paid for upon the  exercise of options,
pursuant to the terms and  conditions  of the Plan and the  Agreements,  will be
validly issued and will be fully paid and nonassessable.

         In  connection  with any issue and sale of the Shares,  steps should be
taken to effect  compliance with all applicable  laws,  rules and regulations of
governmental authorities regulating sales and offerings of securities.

         We understand  that this opinion is to be used in  connection  with the
Registration  Statement.  We consent to the filing of this opinion as an exhibit
to the Registration Statement and to the use of our name therein.

                                                     Very truly yours,

                                                     /s/ Ropes & Gray

                                                     Ropes & Gray

                                      -21-



<PAGE>



                                                                EXHIBIT 23(b)

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

         As   independent   public   accountants,   we  hereby  consent  to  the
incorporation  by  reference in this Registration Statement of our reports
dated  October 4, 1995 (except with respect to the matter  discussed 
in Note 10(b) as to which the date is December 6,  1995) in Genome Therapeutics
Corp.'s Form 10-K for the year ended August 31, 1995 and to all references 
to our Firm  included  in this Registration Statement.


                                                     /s/ Arthur Andersen LLP
                                                     ARTHUR ANDERSEN LLP


November 7, 1996

<PAGE>                                 
                                      -22-


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