GENOME THERAPEUTICS CORP
POS EX, EX-1.1, 2000-06-27
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                                     EXHIBIT 1.1


                          CASH ACCOUNT CLIENT AGREEMENT

                                 Tucker Anthony
                                 1 Beacon Street
                           Boston, Massachusetts 02108

                           One World Financial Center
                               New York, NY 10281


Genome Therapeutics Corp.
100 Beaver Street
Waltham, MA  02453

Dear Client:

         This Agreement sets forth the terms and conditions under which we will
maintain your account for purchases and sales of securities and other property.
Please sign the reverse of the white copy of this Agreement where indicated and
return it in the enclosed envelope.

     1. CLIENT REPRESENTATIONS.

        (A)     If you are an individual, you represent that you are of the age
                of majority, that no one except you has an interest in your
                account and you are not an employee of any exchange or of a
                member firm of any exchange or the NASD, or of a bank, trust
                company, or insurance company unless you have notified us to
                that effect, and you will properly notify us if you become so
                employed.

        (B)     If you are a corporation, trust, partnership or other entity,
                you represent that:

                (i)     You are a duly formed and existing entity under the laws
                        of your state or jurisdiction of formation and are
                        qualified and (if you are a corporation) in good
                        standing in every jurisdiction in which you do business.

                (ii)    The person or persons designated to act for you have
                        been duly authorized by all necessary and appropriate
                        institution action; such person or persons have full
                        authority to execute this Agreement and all related
                        documents on your behalf and to act for you in all
                        matters regarding your account(s); we may at all times
                        rely on the fact of such authority without any duty to
                        investigate into either the authenticity or extent
                        thereof and the party or parties designated as
                        authorized signatories constitute(s) all of the proper
                        and necessary authorized persons.

     2. FINALITY OF REPORTS. Reports of the execution of orders and statements
        of your account shall be conclusive if not objected in forthwith in
        writing after being forwarded by us to you.


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     3. COMMUNICATIONS. Communications may be sent to you at your address given
        above or at such other address as you may hereafter give us in writing,
        and all communications so sent, whether by mail, telegraph, messenger or
        otherwise, shall be deemed given to you personally, whether actually
        received or not.

     4. CREDIT INVESTIGAITON. As part of this agreement you understand an
        investigation may be made pertaining to your credit standing and your
        business conduct. If such investigation is conducted you understand you
        have the right to make written request within a reasonable period of
        time for a complete and accurate disclosure of the nature and scope of
        such investigation.

     5. SECURITY INTEREST AND LIEN. All monies, securities or other property
        which we may at any time be carrying for you in any of your accounts
        (either individually or jointly) or which may at any time be in our
        possession for any purpose, including safekeeping, shall be subject to a
        general lien for the discharge of all your obligations to us, whether or
        however arising and irrespective of whether or not we have made advances
        in connection with such securities or other property, and irrespective
        of the number of accounts that you may have with us, and you hereby
        authorize us to sell and/or purchase any and all securities or other
        property in any of your accounts without notice to satisfy such general
        lien.

     6. IMPARTIAL LOTTERY ALLOCATION. You agree, that in the event we hold on
        your behalf bonds or preferred stocks in street or bearer form which are
        callable in part, you will participate in the impartial lottery
        allocation system of the called securities in accordance with the rules
        of the New York Stock Exchange. Further, you understand when the call is
        favorable no allocation will be made to any account in which we, our
        officers or employees have financial interest until all other Customers
        are satisfied on an impartial lottery basis.

     7. INTRODUCED ACCOUNTS. If we carry your account as clearing broker by
        arrangement with another broker through whose courtesy your account has
        been introduced, then unless we receive from you a written notice to the
        contrary we shall accept from such other broker, without any inquiry or
        investigation by it (i) orders for the purchase or sale in account of
        securities and other property and (ii) any other instructions concerning
        said account. You understand that we shall have no responsibility or
        liability to you for any acts or omissions of such other broker, its
        officers, employees or agents. Any such broker has authorized us to
        enter into this Agreement with you on their behalf and the terms and
        conditions hereof, including the arbitration provision contained in
        paragraph 15 shall be applicable to all matters between such broker and
        you. Each reference to "we" or "us" in paragraph 16 shall be understood
        to include any such broker.

     8. COSTS OF COLLECTION. In the event we have to employ counsel or a
        collection agency to collect any debt balance which you owe, you hereby
        authorize us to charge you for the reasonable costs of collection
        including but not limited to attorneys' fees, court costs and expenses
        whatsoever in nature incurred by us in effecting the collection.

     9. MODIFICATION. Except as herein otherwise expressly provided, no
        provision of this Agreement shall in any respect be waived, altered,
        modified or amended unless in writing and signed by an Executive Vice
        President of our organization. Our failure to insist at any time upon
        strict compliance with this Agreement or with any of its terms, or any
        course of


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conduct on its part, shall in no event constitute a waiver by us of any of our
rights or privileges.

     10. BINDING UPON YOUR ESTATE. You hereby agree that this Agreement and all
         the terms thereof shall be binding upon your heirs, executors,
         administration, personal representatives and assigns.

     11. PARTIAL UNENFORCEABILITY. If any provisions herein are or should become
         inconsistent with any present or future law, rule or regulation of any
         sovereign government or a regulatory body having jurisdiction over the
         subject matter of this Agreement, such provision shall be deemed to be
         rescinded or modified in accordance with any such law, rule or
         regulation. In all other respects, this Agreement shall continue and
         remain in full force and effect.

     12. APPLICABLE LAW AND REGULATIONS. All transactions in your account shall
         be subject to all applicable laws and the rules and regulations of all
         federal, state and self regulatory agencies including but not limited
         to the Board of Governors of the Federal Reserve System and the
         constitution rules and customs of the exchange or marker (and its
         clearing house) where executed.

     13. NEW YORK LAW TO GOVERN. This Agreement shall be deemed to have been in
         the State of New York and shall be construed, and the rights and
         liabilities of the parties determined in accordance with the laws of
         the State of New York.

     14. PARAGRAPH 14 IS EFFECTIVE FOR JOINT ACCOUNTS.

         (A)      If this is a Joint Account, you agree that each of you shall
                  have authority on behalf of this account to buy, sell and
                  otherwise deal in, through or with us as broker or dealer,
                  securities or options to receive for the account,
                  confirmations, statements and communications of every kind, to
                  receive for the account money, securities and other property
                  and to dispose of same, to make for the account, agreements
                  relating to these matters and to termination or modify same or
                  waive any of the provisions thereof, and generally to deal
                  with us as if each of you along were the owner of the account,
                  all without notice to the other tenant. The liability of the
                  undersigned for the account shall be joint and several.

         (B)      We may follow the instructions of any one of you concerning
                  the account and make deliveries to any of you, of any or all
                  securities in this account, and make payments to any of you,
                  of any or all monies in this account as any of you may order
                  and direct, even if such delivers and/or payments shall be
                  made to one of you personally, and not for this account. We
                  shall be under no obligation to inquire into the purpose of
                  any such demand for delivery of securities or payment, and we
                  shall not be bound to see to the application of disposition of
                  the said securities and/or monies so delivered or paid to any
                  of you.

         (C)      In the event of the death of any of you, the survivor(s) shall
                  immediately give us written notice thereof, and we may before
                  or after receiving such notice, take such proceedings, require
                  such documents, retain such portion an/or restrict transaction
                  in


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                  the account as we may deem advisable to protect us against any
                  tax, liability, penalty, or loss under any present or future
                  laws or otherwise. The estate of any of you who shall have
                  died shall be liable and each survivor will be liable, jointly
                  and severally, to us for any debt or loss in this account
                  resulting from the completion of transaction initiated prior
                  to our receipt of written notice of such death or incurred in
                  the liquidation of the account or the adjustment of these
                  interests of the respective parties.

         (D)      Any taxes or other expenses becoming a lien against or being
                  payable out of the account as the result of the death of any
                  of you, or through the exercise by his or her estate or
                  representatives of any rights to the account shall be
                  chargeable against the interest of the survivor(s) as well as
                  against the interest of the state of the decedent. This
                  provision shall not release the decedent's estate from any
                  liability provided for in this Agreement.

         (E)      DESIGNATION OF TENANCY:

                  (i)      Joint Tenants with Rights of Survivorship/when one
                           dies his or her interest passes to the survivor(s).

                           We will presume that it is your intention to create
                           an estate or account as joint tenants with rights of
                           survivorship and not, as tenants-in-common, unless
                           you otherwise provide by striking this paragraph
                           ("i") hereafter. In the event of the death of either
                           or any of you, the entire interest in the joint
                           account shall be vested in the survivor on the same
                           terms and conditions as thereof or held, without in
                           any manner, releasing the decedent's estate from the
                           liability.

                  (ii)     Tenants-In-Common without Rights of Survivorship/when
                           one dies, his or her interest passes to his or her
                           estate.

                           Having stricken paragraph ("i") above and filled in
                           the terms of this paragraph ("ii") below, it is your
                           intention to create an estate or account as
                           tenants-in-common without rights of survivorship and
                           not as joint tenants. Your interests in the account
                           shall be set forth below. In the event of the death
                           of either of any of you, the interests in the account
                           shall be determined as of the close of business on
                           the date of death of the descendent (or on the next
                           following business day) as follows:



------------------------------------------------------
Name of Tenant    or his or her estate               %


------------------------------------------------------
Name of Tenant    or his or her estate               %


------------------------------------------------------
Note: Total percentage must equal 100%


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Indicate names and percentage amounts of the interest of each tenant. The only
names to be inserted are those of the present owners of the account; heirs or
beneficiaries CANNOT be designated on this form.

         (F)      COMMUNITY PROPERTY ACCOUNTS. If you desire to open a community
                  property account with us, in addition to signing and returning
                  to us this Client Agreement, you must sign and return a
                  separate Community Property Agreement.

     15. ARBITRATION DISCLOSURES.

          -    ARBITRATION IS FINAL AND BINDING ON THE PARTIES.

          -    THE PARTIES ARE WAIVING THEIR RIGHT TO SEEK REMEDIES IN COURT,
               INCLUDING THE RIGHT TO JURY TRIAL.

          -    PRE-ARBITRATION DISCOVERY IS GENERALLY MORE LIMITED THAN AND
               DIFFERENT FROM COURT PROCEEDINGS.

          -    THE ARBITRATORS' AWARD IS NOT REQUIRED TO INCLUDE FACTUAL
               FINDINGS OR LEGAL REASONING AND ANY PARTY'S RIGHT TO APPEAL OR TO
               SEEK MODIFICATION OF RULINGS BY THE ARTIBTRATORS IS STRICTLY
               LIMITED.

          -    THE PANEL OF ARBITRATORS WILL TYPICALLY INCLUDE A MINORITY OF
               ARBITRATORS WHO WERE OR ARE AFFILIATED WITH THE SECURITIES
               INDUSTRY.

     16. ARBITRATION. CLIENT AGREES THAT ALL CONTROVERSIES THAT MAY ARISE
         BETWEEN CLIENT AND US, CONCERNING ANY TRANSACTIONS OF THE CONSTRUCTION,
         PERFORMANCE, OR BREACH OF THIS OR ANY OTHER AGREEMENT BETWEEN CLIENT
         AND US PERTAINING TO SECURITIES AND OTHER PROPERTY, WHETHER ENTERED
         INTO PRIOR, ON OR SUBSEQUENT TO THE DATE HEREOF, SHALL BE DETERMINED BY
         ARBITRATION. ANY ARBITRATION UNDER THIS AGREEMENT SHALL BE CONDUCTED
         PURSUANT TO THE FEDERAL ARBITRATION ACT AND THE LAWS OF THE STATE
         DESIGNATED IN PARAGRAPH 13. BEFORE THE NEW YORK STOCK EXCHANGE, INC. OR
         THE ARBITRATION FACILITY PROVIDED BY ANY OTHER EXCHANGE OF WHICH WE ARE
         A MEMBER, OR THE NATIONAL ASSOCIATION OF SECURITIES DEALERS, INC. OR
         THE MUNICIPAL SECURITIES RULEMAKING BOARD AND IN ACCORDANCE WITH THE
         RULES OBTAINING OF THE SELECTED ORGANIZATION. THE CLIENT MAY ELECT IN
         THE FIRST INSTANCE WHETHER ARBITRATION SHALL BE AN EXCHANGE OR
         SELF-REGULATORY ORGANIZATION OF WHICH WE ARE A MEMBER, BUT IF THE
         CLIENT FAILS TO MAKE SUCH ELECTION BY REGISTERED LETTER OR TELEGRAM
         ADDRESSED TO US AT OUR MAIN OFFICE BEFORE THE EXPIRATION OF TEN DAYS
         AFTER RECEIPT OF A WRITTEN REQUEST FROM US TO MAKE SUCH ELECTION, THEN
         WE MAY MAKE SUCH ELECTION. THE AWARD OF THE ARBITRATORS, OR OF THE
         MAJORITY OFTHEM, SHALL BE FINAL, AND JUDGMENT UPON THE AWARD RENDERED
         MAY BE ENTERED IN ANY COURT, ST ATE OR FEDERAL, HAVING JURISDICTION.

         NO PERSON SHALL BRING A PUNATIVE OR CERTIFIED CLASS ACTION TO
         ARBITRATION, NOR SEEK TO ENFORCE ANY PRE-DISPUTE ARBITRATION

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         AGREEMENT AGAINST ANY PERSON WHO HAS INITIATED IN COURT A PUNATIVE
         CLASS WHO HAS NOT OPTIONED OUT OF THE CLASS WITH RESPECT TO ANY CLAIMS
         ENCOMPASSED BY THE PUNATIVE CLASS UNTIL (I) THE CLASS CERTIFICATION IS
         DENIED; (II) THE CLIENT IS EXCLUDED FROM THE CLASS BY THE COURT. SUCH
         FORBEARANCE TO ENFORCE THE AGREEMENT TO ARBITRATE SHALL NOT CONSITUTE A
         WAIVER OF ANY RIGHTS UNDER THIS AGREEMENT EXCEPT TO THE EXTENT STATED
         THEREIN.

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I.       NOTE:

         IF AN INDIVIDUAL ACCOUNT, this Agreement must be signed and dated in
         the TWP PLACES marked "Client's Signature".

         IF A JOINT ACCOUNT WITH RIGHTS OF SURVIVORSHIP, this Agreement must be
         signed and dated in FOUR PLACES (the two places marked "Client
         Signature" and the two places marked "Joint Party's Signature")

         IF THIS ACCOUNT IS A TENANCY-IN-COMMON, this Agreement must be signed
         and dated by all PARTIES to the tenancy-in-common, in both sections of
         the signature area. Paragraph 14 must also be completed to establish a
         tenancy-in-common.

         IF AN INSTITUTIONAL ACCOUNT, this Agreement must be signed at the place
         marked "Signature of Authorized Signatory".

  THIS AGREEMENT CONTAINS A PRE-DISPUTE ARBITRATION CLAUSE AT PARAGRAPHS 15 AND
  16. BY SIGNING THIS AGREEMENT YOU ACKNOWLEDGE THAT YOU HAVE RECEIVED AND
  RETAINED A COPY OF THIS AGREEMENT.



-------------------------------------     -------------------------------------
Client's Signature              Date         Joint Party's Signature       Date



/s/ Philip V. Holberton                     Chief Financial Offic       6/16/00
-------------------------------------------------------------------------------
Signature(s) of Authorized Signatory        Title/Position              Date


II.      Substitute W-9 Payer's request for Taxpayer Identification Number (see
         instruction on page 3)

Part 1 - Taxpayer Identification Number: Enter the taxpayer identification
number here. For most individual taxpayers, this is the Social Security Number.
Note: If the account is in more than one name, see the chart on the attached
instructions for guidelines on which number to give us.

The Taxpayer or Social Security Number is:  __________________

Part 2 - Backup Withholding Number: Check the box if you are not subject to
backup withholding the provisions of Section 3406(a)(1)(c) of the Internal
Revenue Code (see instructions) [ ] Not subject to Backup Withholding

Certification under the penalties of perjury, I certify that the information
provided on this form is true, correct and complete

/s/ Philip V. Holberton    6/16/00
----------------------------------        -------------------------------------
Client's Signature         Date           Joint Party's Signature          Date


III.     Client Survey Re: SEC Rule 14b-1 (c)

No [ ] I do not want my name, address and security position released to
requesting companies in which I hold securities. Your brokerage firm is legally
obligated to disclose your identity to requesting companies unless you respond
with a "No" response to this survey. It is not necessary to respond to this
inquiry if you have no objection to release of this information.


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LACK OF RESPONSE TO THIS INQUIRY WILL LEGALLIY OBLIGATE US TO DISCLOSE YOUR
IDENTITY TO REQUESTING COMPANIES IN WHICH YOU HOLD SECURITIES.


/s/ Philip V. Holberton    6/16/00
----------------------------------        -------------------------------------
Client's Signature         Date           Joint Party's Signature          Date


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