PUTNAM HEALTH SCIENCES TRUST
N-30D, 1995-05-08
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PUTNAM
HEALTH
SCIENCES
TRUST 

SEMIANNUAL REPORT 
February 28, 1995 

                               (Balance Scales) 
                    B O S T O N * L O N D O N * T O K Y O 

<PAGE>
 
Performance highlights

> The fund's class A shares ranked in the top 13% of 15 funds in Lipper's 
  health/biotechnology fund category for one-year performance ended 2/28/95.* 

> Performance should always be considered in light of a fund's investment 
  strategy. Putnam Health Sciences Trust is designed for investors seeking 
  capital appreciation through investments in the health sciences industries. 

SEMIANNUAL RESULTS AT A GLANCE 

<TABLE>
<CAPTION>
                                  Class A                 Class B 
Total return                  NAV         POP         NAV         CDSC 
<S>                   <C>     <C>         <C>         <C>         <C>
(change in value 
  during period plus 
  reinvested 
  distributions) 
  6 months ended 
  2/28/95                       9.57%       3.26%       9.17%       4.17% 
Share value                               NAV         POP         NAV 

8/31/94                                   $29.77      $31.59      $29.47 
2/28/95                                    31.79       33.73       31.49 
                                          Long-term 
Distributions:        No.     Income      capital gains           Total 

Class A               1       $0.257      $0.516                  $0.773 
Class B               1        0.120       0.516                   0.636 
</TABLE>

Performance data represent past results and will differ for each share class. 
For performance over longer periods, see pages 8 and 9. POP assumes 5.75% 
maximum sales charge for class A shares. CDSC for class B shares assumes 5% 
maximum contingent deferred sales charge. 

*Lipper rankings vary over time and do not include the effects of sales 
charges. Class A shares ranked 2 out of 15, 6 out of 8, and 4 out of 4 
health/biotechnology funds for 1, 5, and 10-year performance, respectively, 
as of 2/28/95. Past performance is not indicative of future results. 

<PAGE>
 
From the Chairman 
(Photo-George Putnam)
(c) Karsh, Ottawa 

Dear Shareholder: 

The massive dose of self-healing prescribed by the health-care industry to 
ward off the threat of governmental intervention continues to pay off for 
investors. Shareholders of Putnam Health Sciences Trust were among the 
beneficiaries during the six months ended February 28, 1995, the period 
encompassing the first half of the fund's current fiscal year. 

Although health-care reform is clearly on Washington's back burner, at least 
for now, companies that heeded the wake-up call by trimming costs and 
otherwise improving efficiency are still recording positive results. 

As time goes on, the benefits of these self-reforms will become less 
pronounced. Nevertheless, we believe the companies that have pursued tighter 
management most assiduously will remain in investors' favor. 

Fund managers Joanne Soja and James Giblin will continue to seek out the most 
promising of these companies for your fund. Joanne and Jim review fiscal 
1995's first half and discuss prospects for the second half in the following 
report. 

Respectfully yours, 
(Signature George Putnam)
George Putnam 
Chairman of the Trustees 
April 19, 1995 

<PAGE>
 
Report from the fund managers 
Joanne Soja 
James F. Giblin 

Health-care-related stocks continued their run of strong performance 
throughout the six months ended February 28, 1995. Putnam Health Sciences 
Trust was a standout in its fund category, receiving high rankings from an 
industry research firm as noted on page 2. Indeed, the fund's total return 
for both class A and class B shares at net asset value and public offering 
price, handily surpassed the S&P 500(R) during this period. 

The impetus for the sector's outperformance was twofold: the withdrawal of 
President Clinton's health-care reform plan, and industry-wide consolidation 
driven by the need for cost cutting. Investors once again pursued 
health-care-related stocks, bidding up stock prices. Several big mergers and 
acquisitions -- including American Home Products' $9.7 billion acquisition of 
American Cyanamid and Glaxo's hostile takeover of Burroughs Wellcome -- also 
reignited interest in the sector. 

Our broad-based investment approach, which emphasizes a variety of 
health-sector industries, has served your fund well. The following discussion 
summarizes our strategies during the semiannual period and offers insights 
into what we believe may lie ahead. 

> PHARMACEUTICALS/MEDICAL DEVICES: THE ENGINE DRIVING PERFORMANCE 

Ethical pharmaceutical stocks remained your fund's largest industry weighting 
throughout the period, making up more than one third of net assets. The 
second largest subsector, at nearly 25.4% of net assets, was medical supplies 
and devices. 

Many of the fund's holdings in this subsector were impacted because of the 
psychology of the health care reform. They recovered nicely after the demise 
of the reform program. Our focus on these areas enabled your fund to provide 
exceptional performance throughout the period. Aggressive restructurings, the 
prospect of ongoing merger activity, and replenishment of inventories by 
providers and hospitals also helped boost price appreciation. 

<PAGE>
 
The companies we've selected have shown the ability to develop and market new 
products. For example, Medtronic, Inc., consistently a leader in the 
production of traditional pacemakers, has developed an innovative new 
implantable defibrillator which regulates the pace of too-rapid heartbeats. 
We have increased the fund's holdings in Medtronic, Inc. 

As we progress through fiscal 1995, we will maintain a watchful eye on 
potential pricing pressures. The companies that have prepared themselves for 
such pressures, either through strategic realignments or enhanced sales and 
research efforts, should be able to sustain their current growth levels. As 
part of our broad-based diversification strategy, we are also closely 
examining several newer approaches to the delivery of health-care services. 

> MANAGED CARE ADDS TO FUND PERFORMANCE 

Health maintenance organizations (HMOs) and medical service providers which 
help to manage care, continue to enjoy robust earnings. Corporations such as 
United Healthcare Corp., and Columbia/HCA Healthcare Corp., have been able to 
respond to payers' demands and deliver quality health care at lower costs. 

Despite ongoing concerns about the potential tug-of-war between price 
inflation and low locked-in premiums, we believe many HMOs are well 
positioned for future growth. Not only have these companies experienced 
strong enrollment increases, but preventive care and early diagnosis of 
diseases have improved as well. And now, Medicare and Medicaid appear as 
large potential markets as federal and state governments increasingly direct 
the programs' recipients toward managed care. A typical Medicare enrollee can 

(Bar Chart)
TOP INDUSTRY SECTORS* (2/28/95)

Ethical pharmaceuticals         35.4%
Medical supplies and devices    25.4%
Hospital management
 and health care                22.2%
Biotechnology                    6.4%
*Based on percentage of net assets.
(End of bar chart)
<PAGE>
 
generate up to three times as much revenue for these firms as healthy younger 
members. 

Therefore, as the largest service business in the United States -- 
health-care spending is roughly 14% of gross domestic product -- we believe 
this industry group maintains a firm foothold on growth. We're confident our 
position on managed care will be a distinguishing factor in your fund's 
performance. 

> NON-HEALTH-RELATED ISSUES HAVE BEEN ELIMINATED 

By mid-year 1994, we had eliminated nearly all the fund's exposure to 
securities outside the health sciences industries. The valuation of 
health-care industry stocks became extremely compelling. Additionally, the 
economic and market landscape has since changed, favoring the industry as a 
whole. Our broad-based allocation within the industry, however, will remain 
in force, as we believe it provides the fund with the flexibility to pursue 
various avenues of growth. 

Biotechnology stocks remain a relatively small part of the portfolio, with 
emphasis given to those firms exhibiting strong clinical results and the 
ability to establish creative alliances with pharmaceutical companies and 
medical suppliers. Given the financial pressure many of these firms are 
facing, theirs remains very much a "show me" story. 

> OUTLOOK: LONG-TERM PROSPECTS REMAIN STRONG 

We believe health-care industries, from HMOs to drug companies, are in good 
shape. Within the past two years, the industry as a whole has gotten leaner 
and tougher while medical price inflation has fallen dramatically. 

In our opinion, the aging of America will necessitate a strong health-care 
infrastructure and improved standards of living in the developing world, 
allowing for increased market penetration by pharmaceutical firms. Companies 
with unique products and innovative solutions to unmet health-care needs will 
be in the best position to succeed. Recent discussions within the Federal 
Drug Administration point to greater responsiveness to the needs of 
pharmaceutical, medical devices, and biotech firms--particularly the medical 
devices area, which has endured substantial delays in new-product approvals 
in the past. Certain other health-care subsectors, such as information 
services, also hold promise. 

<PAGE>
 
TOP 10 HOLDINGS (2/28/95) 

 Abbott Laboratories 
 Medical supplies and devices 
........................................................................... 
 Johnson & Johnson 
 Medical supplies and devices 
........................................................................... 
 Merck & Co. Inc. 
 Ethical pharmaceuticals 
........................................................................... 
 SmithKline Beecham PLC ADR 
 Ethical pharmaceuticals 
........................................................................... 
 Pfizer Inc. 
 Ethical pharmaceuticals 
........................................................................... 
 United Healthcare Corp. 
 Hospital management and health-care services 
........................................................................... 
 American Home Products Corp. 
 Ethical pharmaceuticals 
........................................................................... 
 Medtronic, Inc. 
 Medical supplies and devices 
........................................................................... 
 U.S. Healthcare Inc. 
 Hospital management and health-care services 
........................................................................... 
 Lilly (Eli) & Co. 
 Ethical pharmaceuticals 

These holdings represent 46.8% of the fund's assets. Portfolio holdings are 
subject to change over time. 

In general, consumers seem to have regained their confidence in the 
health-care delivery system, believing that physicians, hospitals, and 
pharmaceutical and device companies are making greater strides in improving 
the quality of life. We believe health care will remain an industry that has 
the potential to grow faster than the overall economy, and that those 
companies delivering a quality solution to a medical need should continue to 
offer significant growth potential. 

The views expressed here are exclusively those of Putnam Management. They are 
not meant as investment advice. Although the described holdings were viewed 
favorably as of February 28, 1995, there is no guarantee the fund will 
continue to hold these securities in the future. 

<PAGE>
 
Performance summary 

This section provides, at a glance, information about your fund's 
performance. Total return shows how the value of the fund's shares changed 
over time, assuming you held the shares through the entire period and 
reinvested all distributions back into the fund. We show total return in two 
ways: on a cumulative long-term basis and on average how the fund might have 
grown each year over varying periods. For comparative purposes, we show how 
the fund performed relative to appropriate indexes and benchmarks. 

TOTAL RETURN FOR PERIODS ENDED 2/28/95 

<TABLE>
<CAPTION>
                                                                    Standard      Consumer 
                           Class A                Class B           & Poor's        Price 
                         NAV        POP         NAV     CDSC       500 Index        Index 
<S>                  <C>         <C>         <C>        <C>        <C>              <C>
6 months               9.57%       3.26%       9.17%     4.17%        3.98%          1.28% 
1 year                22.40       15.35       21.49     16.49         7.41           2.86 
5 years              105.46       93.68        --         --         71.25          17.89 
Annual average        15.49       14.13        --         --         11.36           3.35 
10 years             346.54      320.86        --         --        273.77          42.36 
Annual average        16.14       15.46        --         --         14.09           3.59 
Life of shares         --          --         35.16     31.16        16.31           5.45 
Annual average         --          --         16.26     14.53         7.85           2.69 
</TABLE>
TOTAL RETURN FOR PERIODS ENDED 3/31/95 
(most recent calendar quarter) 

<TABLE>
<CAPTION>
                           Class A                 Class B 
                       NAV        POP         NAV         CDSC 
<S>                  <C>         <C>         <C>          <C>
1 year                34.70%      26.97%     33.73%       28.73% 
5 years              103.30       91.65        --            -- 
Annual average        15.25       13.89        --            -- 
10 years             359.64      333.25        --            -- 
Annual average        16.48       15.79        --            -- 
Life of shares          --          --        39.28       36.28 
Annual average          --          --        17.27       16.05 
</TABLE>
Fund performance data do not take into account any adjustment for taxes 
payable on reinvested distributions or, for class A shares, distribution fees 
prior to implementation of the class A distribution plan in 1990. The fund 
began operations on 5/28/82 offering shares now known as class A. Effective 
3/1/93, the fund began offering class B shares. Performance data represent 
past results and will differ for each share class. Investment returns and net 
asset value will fluctuate so an investor's shares, when sold, may be worth 
more or less than their original cost. 

<PAGE>
 
TERMS AND DEFINITIONS 

Class A shares are generally subject to an initial sales charge. 

Class B shares may be subject to a sales charge upon redemption. 

Net asset value (NAV) is the value of all your fund's assets, minus any 
liabilities, divided by the number of outstanding shares, not including any 
initial or contingent deferred sales charge. 

Public offering price (POP) is the price of a mutual fund share plus the 
maximum sales charge levied at the time of purchase. POP performance figures 
shown here assume the maximum 5.75% sales charge for class A shares. 

Contingent deferred sales charge (CDSC) is a charge applied at the time of 
the redemption of class B shares and assumes redemption at the end of the 
period. Your fund's CDSC declines from a 5% maximum during the first year to 
1% during the sixth year. After the sixth year, the CDSC no longer applies. 

COMPARATIVE BENCHMARKS 

Standard & Poor's 500 Index is an unmanaged list of common stocks that is 
frequently used as a general measure of stock market performance. The index 
assumes reinvestment of all distributions and does not take into account 
brokerage commissions or other costs. The fund's portfolio contains 
securities that do not match those in the index. 

Consumer Price Index is a commonly used measure of inflation; it does not 
represent an investment return. 

<PAGE>
 
Portfolio of investments owned 
February 28, 1995 
<TABLE>
<CAPTION>
COMMON STOCKS (96.3%)* 
NUMBER OF SHARES                                                 VALUE 
<C>             <S>                                     <C>
Biotechnology (6.4%) 
    280,000     Amgen Inc. +                           $  19,320,000 
    156,500     Amylin Pharmaceuticals, Inc. +               978,125 
    350,000     Athena Neurosciences, Inc. +               3,106,250 
    100,000     Biochem Pharmaceutical, Inc. +             1,375,000 
    200,000     Biogen, Inc. +                             8,250,000 
    260,000     Cor Therapeutics Inc +                     3,510,000 
    212,500     Genentech, Inc. +                         10,678,125 
    150,000     Mentor Corp. Minnesota                     3,637,500 
    130,100     Quintiles Transnational Corp. +            4,911,275 
     50,000     Thermo Cardiosystems, Inc. +               1,193,750 
    133,400     Vertex Pharmaceuticals Inc +               2,167,750
                                                       ------------- 
                                                          59,127,775 
Computer Software (1.9%) 
     91,600     Cerner Corp. +                             4,247,950 
    220,000     GMIS, Inc. +                               4,730,000 
     25,800     HCIA, Inc. +                                 483,750 
    625,000     Physicians Computer Network +              2,265,625 
    170,000     Shared Medical Systems Corp.               5,854,375
                                                       ------------- 
                                                          17,581,700 
Distribution and Drug Retailing (1.0%) 
    645,000     Owens & Minor, Inc.                        9,030,000 
Ethical Pharmaceuticals (35.4%) 
     65,500     Affymax N.V. +                             1,960,906 
    360,000     Allergan Inc.                             10,395,000 
    560,000     American Home Products Corp.              40,040,000 
    220,000     Bristol-Myers Squibb Co.                  13,640,000 
    120,000     Elan Corp. ADR +                           4,230,000 
    134,100     Forest Laboratories, Inc. Class A +        6,805,575 
    115,000     Ivax Corp.                                 2,486,875 
    440,000     Lilly (Eli) & Co.                         29,480,000 
  1,187,200     Merck & Co., Inc.                         50,307,600 
    120,000     Mylan Laboratories Inc.                    3,750,000 
    542,500     Pfizer Inc.                               44,891,875 
    370,000     Schering Plough Corp.                     28,998,750 
  1,210,000     SmithKline Beecham PLC ADR                47,038,750 
    500,000     Upjohn Co.                                17,625,000 
    340,000     Warner-Lambert Co.                        25,967,500
                                                       ------------- 
                                                         327,617,831 
Health Care (2.5%) 
    289,608     Boston Scientific Corp.                    6,262,794 
     50,900     Cardinal Health, Inc.                      2,519,550 
    130,400     Emcare Holdings, Inc.                      2,200,500 
     20,000     Medpartners, Inc. +                          350,000 

<PAGE>
 
COMMON STOCKS 
NUMBER OF SHARES                                               VALUE 
Health Care (continued) 
    208,200     Rightchoice Managed Care, Inc. 
                Class A                                 $  3,591,450 
     50,000     Target Therapeutics, Inc.                  1,862,500 
    220,000     U.S. Surgical Corp.                        4,620,000 
     50,000     Ventritex, Inc.                            1,050,000 
     50,000     Zoll Medical Corp.                           612,500
                                                       ------------- 
                                                          23,069,294 
Health Care/Medical Electronic (0.2%) 
     44,700     Health Management Systems, Inc.            1,620,375 
Hospital Management and Health Care Services (22.2%) 
     90,000     Apogee, Inc. +                             1,845,000 
    620,000     Beverly Enterprises Inc. +                 8,060,000 
    251,125     Columbia/HCA Healthcare Corp.             10,390,297 
     75,000     Express Scripts, Inc. Class A +            2,550,000 
    235,000     FHP Intl. Corp. +                          6,315,625 
    110,000     Foundation Health Corp. +                  3,286,250 
    210,000     Health Care & Retirement Corp. +           6,510,000 
    250,000     Horizon Healthcare Corp. +                 6,093,750 
    810,000     Humana Inc.                               19,237,500 
    190,000     Manor Care, Inc.                           5,628,750 
    160,000     Medaphis Corp. +                           9,040,000 
     60,000     Medcath, Inc. +                              817,500 
    300,000     Mid Atlantic Medical Services, Inc. +      6,150,000 
    193,100     National Medical Enterprises, Inc.         2,993,050 
    251,000     Pacificare Health Systems Class B +       17,632,750 
    210,000     Quantum Health Resources, Inc. +           4,620,000 
    183,900     Quorum Health +                            3,494,100 
    950,000     United Healthcare Corp.                   40,850,000 
    717,500     U.S. Healthcare Inc.                      30,852,500 
    245,900     Value Health, Inc. +                       9,159,775 
    320,000     Vivra, Inc. +                             10,400,000
                                                       ------------- 
                                                         205,926,847 
Medical Supplies and Devices (25.4%) 
  1,770,000     Abbott Laboratories                       62,835,000 
     60,000     Arrow International, Inc.                  2,235,000 
    480,000     Bard (C.R.), Inc.                         12,840,000 
    723,750     Baxter International Inc.                 22,526,719 
     65,000     Cordis Corp. +                             4,225,000 
    310,000     Haemonetics Corp. +                        4,921,250 
    900,000     Johnson & Johnson                         51,075,000 
    160,000     Medisense Inc.                             3,280,000 
    600,000     Medtronic, Inc.                           36,000,000 
    120,000     Mitek +                                    3,555,000 
    170,000     Nellcor Inc. +                             5,780,000 
    135,000     St. Jude Medical Inc.                      4,893,750 
    478,000     Stryker Corp.                             20,793,000
                                                       ------------- 
                                                         234,959,719 

<PAGE>
COMMON STOCKS 
NUMBER OF SHARES                                               VALUE 
Pharmaceuticals (1.3%) 
    268,000     Astra AB                                $  6,752,287 
     50,000     Ligand Pharmaceuticals, Inc. 
                Class B +                                    343,750 
     50,000     Medimmune, Inc. +                            350,000 
    110,000     R.P. Scherer Corp. +                       5,046,250
                                                       ------------- 
                                                          12,492,287 
                Total Common Stocks (cost 
                $633,160,743)                           $891,425,828 
SHORT-TERM INVESTMENTS (3.9%)* 
PRINCIPAL AMOUNT                                               VALUE 
$10,000,000     Federal Home Loan Banks 5.84s, 
                March 9, 1995                           $  9,987,022 
  1,521,000     Federal Home Loan Mortgage Corp. 
                5.95s, March 1, 1995                       1,521,000 
 10,000,000     General Electric Capital Corp. 
                5.93s, March 14, 1995                      9,978,586 
 15,000,000     Interest in $875,000,000 joint 
                repurchase agreement dated 
                February 28, 1995 with Goldman 
                Sachs & Co. Inc., due March 1, 
                1995 with respect to various U.S. 
                Treasury obligations--maturity 
                value of $15,002,521 for an 
                effective yield of 6.05%                  15,002,521 
                Total Short-Term Investments 
                (cost $36,489,129)                      $ 36,489,129 
                Total Investments 
                (cost $669,649,872)***                  $927,914,957 
</TABLE>
  * Percentages indicated are based on net assets of $925,968,231 which 
correspond to a net asset value per share of Class A and Class B shareholders 
of $31.79 and $31.49, respectively. 
  + Non-income-producing. 
*** The aggregate identified cost on a tax basis is $669,649,872, resulting 
in gross unrealized appreciation and depreciation of $276,032,083, and 
$17,766,998, respectively, or net unrealized appreciation of $258,265,085. 
ADR or ADS after the name of a foreign holding stands for American Depository 
Receipt or American Depository Shares, respectively, representing foreign 
securities on deposit with a domestic custodian bank. 

  The accompanying notes are an integral part of these financial statements. 

<PAGE>
 
Statement of assets and liabilities 
February 28, 1995 (Unaudited) 
<TABLE>

<S>                                                                                <C>
Assets 
Investments in securities, at value (identified cost $669,649,872 ) (Note 1)       $927,914,957 
Cash                                                                                        263 
Dividends and interest receivable                                                     1,518,767 
Receivable for shares of the fund sold                                                4,846,706 
Total assets                                                                        934,280,693 
Liabilities 
Payable for shares of the fund repurchased                                            4,252,299 
Payable for securities purchased                                                      1,907,196 
Payable for compensation of Manager (Note 2)                                          1,422,920 
Payable for administrative services (Note 2)                                              6,482 
Payable for compensation of Trustees (Note 2)                                             2,141 
Payable for investor servicing and custodian fees (Note 2)                              240,590 
Payable for distribution fees (Note 2)                                                  391,460 
Other accrued expenses                                                                   89,374 
Total liabilities                                                                     8,312,462 
Net assets                                                                         $925,968,231 
Represented by 
Paid-in capital (Note 4)                                                           $661,083,679 
Undistributed net investment income                                                   1,106,697 
Accumulated net realized gain on investments                                          5,512,770 
Net unrealized appreciation of investments                                          258,265,085 
Total--Representing net assets applicable to capital shares outstanding            $925,968,231 
Computation of net asset value and offering price 
Net asset value and redemption price of class A shares 
  ($841,450,366 divided by 26,470,650 shares)                                            $31.79 
Offering price per class A share (100/94.25 of $31.79)*                                  $33.73 
Net asset value and offering price of class B shares 
  ($84,517,865 divided by 2,684,262 shares)+                                             $31.49 
</TABLE>
* On single retail sales of less than $50,000. On sales of $50,000 or more and 
on group sales the offering price is reduced. 
+ Redemtion price per share is equal to net asset value less any applicable 
contingent sales charge. 

  The accompanying notes are an integral part of these financial statements. 

<PAGE>
 
Statement of operations 
Six months ended February 28, 1995 (Unaudited) 
<TABLE>
<S>                                                     <C>
Investment income: 
Dividends                                               $  6,819,437 
Interest                                                     699,566 
Total investment income                                    7,519,003 
Expenses: 
Compensation of Manager (Note 2)                           2,816,244 
Investor servicing and custodian fees (Note 2)               594,778 
Compensation of Trustees (Note 2)                             16,305 
Auditing                                                      16,572 
Legal                                                          9,115 
Postage                                                       77,095 
Reports to Shareholders                                       32,897 
Distribution fees--Class A (Note 2)                          986,533 
Distribution fees--Class B (Note 2)                          333,741 
Administrative services (Note 2)                              11,455 
Registration fees                                              2,181 
Other                                                         87,980 
Total expenses                                             4,984,896 
Net investment income                                      2,534,107 
Net realized gain on investments (Notes 1 and 3)           5,520,532 
Net unrealized appreciation of investments during 
  the period                                              71,706,208 
Net gain on investments                                   77,226,740 
Net increase in net assets resulting from                $79,760,847 
  operations 
</TABLE>
  The accompanying notes are an integral part of these financial statements. 

<PAGE>
 
Statement of changes in net assets 
<TABLE>
<CAPTION>
                                                                     Year ended 
                                                                     August 31 
                                                             1995*               1994 
<S>                                                       <C>                <C>
Increase (decrease) in net assets 
Operations: 
Net investment income                                     $  2,534,107       $  7,269,246 
Net realized gain on investments                             5,520,532         37,397,500 
Net unrealized appreciation of investments                  71,706,208        122,395,466 
Net increase in net assets resulting from operations        79,760,847        167,062,212 
Distributions to shareholders from: 
Net investment income 
Class A                                                     (6,672,840)        (7,054,011) 
Class B                                                       (277,402)          (218,378) 
Net realized gain on investments 
Class A                                                    (13,397,610)        (1,518,110) 
Class B                                                     (1,192,827)           (60,825) 
Increase (decrease) from capital share transactions 
  (Note 4)                                                  22,726,193        (96,087,506) 
Total increase in net assets                                80,946,361         62,123,382 
Net assets 
Beginning of period                                        845,021,870        782,898,488 
End of period (including undistributed net investment 
  income of $1,106,697 and $5,522,832, respectively       $925,968,231       $845,021,870 
</TABLE>
* Unaudited. 

  The accompanying notes are an integral part of these financial statements. 

<PAGE>
 
Financial Highlights 
(For a share outstanding throughout the period) 
<TABLE>
<CAPTION>
                                                                   March 1, 1993 
                                     Six months                    (commencement          Six months 
                                       ended       Year ended    of operations) to          ended              Year ended 
                                    February 28     August 31        August 31           February 28            August 31 
                                       1995*          1994             1993+                1995*          1994          1993 
                                                        Class B                                          Class A 
<S>                                 <C>             <C>              <C>                 <C>             <C>           <C>
Net Asset Value, Beginning of 
  Period                              $ 29.47        $ 24.28          $ 24.02              $  29.77      $  24.40      $  28.31 
Investment operations 
Net Investment Income                    (.06)           .10              .05                   .10           .30           .26 
Net Realized and Unrealized Gain 
  (Loss) on Investments                 2.72            5.33              .21                 2.70           5.36         (1.82) 
Total from investment operations        2.66            5.43              .26                 2.80           5.66         (1.56) 
Less Distributions from: 
Net Investment Income                    (.12)          (.19)            --                    (.26)         (.24)         (.13) 
Net Realized Gain on Investments         (.52)          (.05)            --                    (.52)         (.05)        (2.22) 
Total Distributions                      (.64)          (.24)            --                    (.78)         (.29)        (2.35) 
Net Asset Value, End of Period        $ 31.49        $ 29.47          $ 24.28              $  31.79      $  29.77      $  24.40 
Total Investment Return at Net 
  Asset Value (%) (b)                    9.17(c)       22.49             1.08(c)               9.57(c)      23.38         (6.45) 
Net Assets, End of Period 
  (in thousands)                      $84,518        $55,424          $18,455              $841,450      $789,598      $764,443 
Ratio of Total Expenses to 
  Average Net Assets (%)                  .92(c)        1.87              .96(c)                .55(c)       1.12          1.13 
Ratio of Net Investment Income 
  to Average Net Assets (%)              (.05)(c)        .24              .21(c)                .32(c)        .96          .91 
Portfolio Turnover (%)                  40.90(c)      23.18             45.46(c)              40.90(c)      23.18         45.46 
</TABLE>

<PAGE>
 
<TABLE>
<CAPTION>
                                              Year ended August 31 
    1992           1991          1990          1989          1988          1987          1986           1985 
                                                     Class A 
<S>              <C>           <C>           <C>           <C>           <C>           <C>            <C>
  $31.29         $  22.82      $  21.81      $  18.55      $  24.39      $  22.46      $  18.47       $  15.96 

     .12              .25           .27           .39         .25(a)          .17           .20            .22 

    (.35)            9.07          2.85          5.21         (4.67)         4.70          6.67           2.99 

    (.23)            9.32          3.12          5.60         (4.42)         4.87          6.87           3.21 

    (.27)            (.35)         (.30)         (.29)         (.12)         (.20)         (.22)          (.16) 

   (2.48)            (.50)        (1.81)        (2.05)        (1.30)        (2.74)        (2.66)          (.54) 
   (2.75)            (.85)        (2.11)        (2.34)        (1.42)        (2.94)        (2.88)          (.70) 
$  28.31         $  31.29      $  22.82      $  21.81      $  18.55      $  24.39      $  22.46       $  18.47 

   (1.12)           41.99         15.01         34.15        (18.79)        27.68         45.12          21.38 

$970,412         $676,081      $335,080      $270,712      $244,169      $347,540      $289,545       $236,588 

    1.20             1.18          1.18          1.14          1.08(a)       1.03          1.00            .99 

     .61             1.27          1.44          1.88        1.22(a)          .82          1.01           1.05 
   42.12            26.59         37.30         25.11         20.85         33.35         31.14          42.75 
</TABLE>
* Unaudited. 
(a) Reflects an expense limitation during the year ended August 31, 1988. As 
a result of such limitation, expenses of 
the fund reflect a reduction of $0.02 per share. 
(b) Total investment return assumes dividend reinvestment and does not 
reflect the effect of sales charges. 
(c) Not annualized. 
+ Per share net investment income has been determined on the basis of the 
weighted average number of shares 
outstanding during the period. 

<PAGE>
 
Notes to financial statements 
August 31, 1994 (Unaudited) 

Note 1 
Significant accounting policies 

The fund is registered under the Investment Company Act of 1940, as amended, 
as a diversified, open-end management investment company. The investment 
objective of the fund is to seek capital appreciation by investing primarily 
in the common stocks of companies in the health sciences industries. 

The fund offers both class A and class B shares. Class A shares are sold with 
a maximum front-end sales charge of 5.75%. Class B shares do not pay a 
front-end sales charge but pay a higher ongoing distribution fee than class A 
shares, and may be subject to a contingent deferred sales charge if those 
shares are redeemed within six years of purchase. Expenses of the fund are 
borne pro-rata by the holders of both classes of shares, except that each 
class bears expenses unique to that class (including the distribution fees 
applicable to such class) and votes as a class only with respect to its own 
distribution plan or other matters on which a class vote is required by law 
or determined by the Trustees. Shares of each class would receive their pro- 
rata share of the net assets of the fund, if the fund were liquidated. In 
addition, the Trustees declare separate dividends on each class of shares. 

The following is a summary of significant accounting policies consistently 
followed by the fund in the preparation of its financial statements. The 
policies are in conformity with generally accepted accounting principles. 

A) Security valuation Investments for which market quotations are readily 
available are stated at market value, which is determined using the last 
reported sale price, or, if no sales are reported--as in the case of some 
securities traded over-the-counter--the last reported bid price, except that 
certain U.S. government obligations are stated at the mean between the last 
reported bid and asked prices. Short-term investments having remaining 
maturities of 60 days or less are stated at amortized cost, which 
approximates market value and other investments are stated at fair value 
following procedures approved by the Trustees. Foreign securities quoted in 
foreign currencies are translated into U.S. dollars at the current exchange 
rate. The fair value of restricted securities is determined by the Manager 
following procedures approved by the Trustees, and such valuations and 
procedures are reviewed periodically by the Trustees. 

B) Joint trading account Pursuant to an exemptive order issued by the 
Securities and Exchange Commission, the fund may transfer uninvested cash 
balances into a joint trading account, along with the cash of other 
registered investment companies managed by Putnam Investment Management, Inc. 
(Putnam Management), the fund's Manager, a wholly-owned subsidiary of Putnam 
Investments, Inc. and certain other accounts. These balances may be invested 
in one or more repurchase agreements and/or short-term money market 
instruments. 

<PAGE>
 
C) Repurchase agreements The fund or any joint trading account, through the 
fund's custodian, receives delivery of the underlying securities, the market 
value of which at the time of purchase is required to be in an amount at 
least equal to the resale price, including accrued interest. The fund's 
Manager is responsible for determining that the value of these underlying 
securities is at all times at least equal to the resale price, including 
accrued interest. 

D) Security transactions and related investment income Security transactions 
are accounted for on the trade date (date the order to buy or sell is 
executed). Interest income is recorded on the accrual basis and dividend 
income is recorded on the ex-dividend date, except that certain dividends 
from foreign securities are recorded as soon as the fund is informed of the 
ex-dividend date. 

E) Federal taxes It is the policy of the fund to distribute all of its income 
within the prescribed time and otherwise comply with the provisions of the 
Internal Revenue Code applicable to regulated investment companies. It is 
also the intention of the fund to distribute an amount sufficient to avoid 
imposition of any excise tax under Section 4982 of the Internal Revenue Code 
of 1986. Therefore, no provision has been made for federal taxes on income, 
capital gains or unrealized appreciation of securities held and excise tax on 
income and capital gains. 

F) Distributions to shareholders Distributions to shareholders are recorded 
by the fund on the ex-dividend date. 

The amount and character of income and gains to be distributed are determined 
in accordance with income tax regulations which may differ from generally 
accepted accounting principles. These differences include the treatment of 
wash sales, foreign currency gains and losses, and post-October loss 
deferrals. 

Note 2 
Management fee, administrative services, and other transactions 

Compensation of Putnam Management, for management and investment advisory 
services is paid quarterly based on the average net assets of the fund for 
the quarter. Such fee is based on the following annual rates: 0.70% of the 
first $500 million of average net assets, 0.60% of the next $500 million, 
0.55% of the next $500 million, and 0.50% of any excess over $1.5 billion, 
subject to reduction in any year to the extent that expenses (exclusive of 
distribution fees, brokerage, interest and taxes) of the fund exceed 2.5% of 
the first $30 million of average net assets, 2% of the next $70 million and 
1.5% of any excess over $100 million and by the amount of certain brokerage 
commissions and fees (less expenses) received by affiliates of the Manager on 
the fund's portfolio transactions. 

The fund also reimburses the Manager for the compensation and related 
expenses of certain officers of the fund and their staff who provide 
administrative services to the fund. The aggregate amount of all such 
reimbursements is determined annually by the Trustees. 

Trustees of the fund receive an annual Trustee's fee of $1,730 and an 
additional fee for each Trustees' meeting attended. Trustees who are not 
interested persons of the Manager and who serve on committees of the Trustees 
receive additional fees for attendance at certain committee meetings. 

Custodial functions for the fund are provided by Putnam Fiduciary Trust 
Company (PFTC), a subsidiary of Putnam Investments, Inc. Investor servicing 
agent functions are provided by Putnam Investor Services, a division of PFTC. 

<PAGE>
 
Investor servicing and custodian fees reported in the Statement of operations 
for the period ended February 28, 1995 have been reduced by credits allowed 
by PFTC. 

The fund has adopted distribution plans (the "Plans") with respect to its 
class A shares and class B shares pursuant to Rule 12b-1 under the Investment 
Company Act of 1940. The purpose of the Plans is to compensate Putnam Mutual 
Funds Corp., a wholly-owned subsidiary of Putnam Investments Inc., for 
services provided and expenses incurred by it in distributing each class of 
shares of the fund. The Trustees have approved payments by the fund at an 
annual rate of 0.25% and up to 1.00% of the average net assets attributable 
to class A and class B shares, respectively. 

For the period ended February 28, 1995, Putnam Mutual Funds Corp., acting as 
underwriter received net commissions of $752,955 from the sale of class A 
shares and $219,739 in contingent deferred sales charges from redemptions of 
class B shares. 

A deferred sales charge of up to 1.00% is assessed on certain redemptions of 
class A shares purchased as part of an investment of $1 million or more. For 
the period ended February 28, 1995, Putnam Mutual Funds Corp., acting as 
underwriter, received $119 on class A redemptions. 

Note 3 
Purchases and sales of securities 

During the period ended February 28, 1995, purchases and sales of investment 
securities other than short-term investments aggregated $348,426,539 and 
$343,455,237, respectively. There were no purchases or sales of U.S. 
government obligations during the year. In determining the net gain or loss 
on securities sold, the cost of securities has been determined on the 
identified cost basis. 

Note 4 
Capital shares 

At February 28, 1995, there was an unlimited number of shares of beneficial 
interest authorized, divided into two classes, class A and class B capital 
stock. Transactions in capital shares were as follows: 

<PAGE>
 
<TABLE>
<CAPTION>
                            Six months ended February 28                Year ended August 31 
                                        1995                                    1994 
Class A                     Shares              Amount              Shares               Amount 
<S>                       <C>                <C>                  <C>                 <C>
Shares sold                3,915,403         $ 118,994,200          6,392,086         $ 167,778,186 
Shared issued in 
connection with 
reinvestment of 
distributions                534,895            15,848,976            254,000             6,576,169 
                           4,450,298           134,843,176         6,646,086            174,354,355 
Shares repurchased        (4,500,172)         (136,421,225)       (11,457,249)         (299,677,276) 
Net increase 
(decrease)                   (49,874)        $  (1,578,049)        (4,811,163)        $ (125,322,921) 
                                Six months ended February 28                     Year ended August 31 
                                           1995                                     1994 
Class B                      Shares                Amount             Shares                Amount 
Shares sold                1,332,097         $  40,119,439          1,447,812         $  37,873,012 
Shares issued in 
connection with 
reinvestment of 
distributions                 41,296             1,213,701              8,743               225,304 
                           1,373,393            41,333,140          1,456,555            38,098,316 
Shares repurchased          (569,726)          (17,028,898)          (335,909)           (8,862,901) 
Net increase 
(decrease)                   803,667         $  24,304,242          1,120,646         $  29,235,415 
</TABLE>

<PAGE>
 
Our commitment to quality service

>CHOOSE AWARD-WINNING SERVICE. 
Putnam Investor Services has won the DALBAR Quality Tested Service Seal for 
the past five years, through 1994. DALBAR, an independent research firm, ran 
more than 12,000 tests of 38 shareholder service components. In every 
category, Putnam outperformed the industry standard. 

> HELP YOUR INVESTMENT GROW. 
Set up a systematic program for investing with as little as $25 a month from 
a Putnam fund or from your own checking or savings account.* 

> SWITCH FUNDS EASILY. 
You can move money from one account to another with the same class of shares 
without a service charge. (This privilege is subject to change or 
termination.) 

> ACCESS YOUR MONEY QUICKLY. 
You can get checks sent regularly or redeem shares any business day at the 
then-current net asset value, which may be more or less than their original 
cost. 

For details about any of these or other services, contact your financial 
advisor or call the toll-free number shown below and speak with a helpful 
Putnam representative. 

> To make an additional investment in this or any other Putnam fund, contact 
  your financial advisor or call our toll-free number: 1-800-225-1581. 

*Regular investing, of course, does not guarantee a profit or protect against 
a loss in a declining market. Investors should consider their ability to 
continue purchasing shares during periods of low price levels. 

<PAGE>
 
Fund information

INVESTMENT MANAGER 
Putnam Investment 
Management, Inc. 
One Post Office Square 
Boston, MA 02109 

MARKETING SERVICES 
Putnam Mutual Funds Corp. 
One Post Office Square 
Boston, MA 02109 

CUSTODIAN 
Putnam Fiduciary Trust Company 

LEGAL COUNSEL 
Ropes & Gray 

TRUSTEES 
George Putnam, Chairman 
William F. Pounds, Vice Chairman 
Jameson Adkins Baxter 
Hans H. Estin 
John A. Hill 
Elizabeth T. Kennan 
Lawrence J. Lasser 
Robert E. Patterson 
Donald S. Perkins 
George Putnam, III 
Eli Shapiro 
A.J.C. Smith 
W. Nicholas Thorndike 

OFFICERS 
George Putnam 
President 
Charles E. Porter 
Executive Vice President 
Patricia C. Flaherty 
Senior Vice President 
John R. Verani 
Vice President 
Lawrence J. Lasser 
Vice President 
Gordon H. Silver 
Vice President 
Peter Carman 
Vice President 
Brett C. Browchuk 
Vice President 
John J. Morgan, Jr. 
Vice President 
Joanne Soja 
Vice President and Fund Manager 
James F. Giblin 
Vice President and Fund Manager 
William N. Shiebler 
Vice President 
Paul M. O'Neil 
Vice President 
John D. Hughes 
Vice President and Treasurer 
Beverly Marcus 
Clerk and Assistant Treasurer 

This report is for the information of shareholders of Putnam Health Sciences 
Trust. It may also be used as sales literature when preceded or accompanied 
by the current prospectus, which gives details of sales charges, investment 
objectives and operating policies of the fund, and the most recent copy of 
Putnam's Quarterly Performance Summary. For more information or to request a 
prospectus, call toll free 1-800-225-1581. 

Shares of mutual funds are not deposits or obligations of, or guaranteed or 
endorsed by, any financial institution, are not insured by the Federal 
Deposit Insurance Corporation (FDIC), the Federal Reserve Board or any other 
agency, and involve risk, including the possible loss of principal amount 
invested. 

<PAGE>
 
Bulk Rate 
U.S. Postage 
PAID 
Putnam 
Investments 
021/335-17495 

The Putnam Funds 
One Post Office Square 
Boston, Massachusetts 02109 

                    B O S T O N * L O N D O N * T O K Y O 
 

<PAGE>

APPENDIX TO FORM N-30D FILINGS TO DESCRIBE DIFFERENCES BETWEEN PRINTED
AND EDGAR-FILED TEXTS:

(1)  Bold and italic typefaces are displayed in normal type.

(2)  Headers (e.g., the name of the fund) are omitted.

(3)  Certain tabular and columnar headings and symbols are displayed 
     differently in this filing.

(4)  Bullet points and similar graphic signals are omitted.

(5)  Page numbering is omitted.

(6)  Trademark symbol replaced with (TM)


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