PUTNAM HEALTH SCIENCES TRUST
497, 2000-03-02
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Prospectus

December 30, 1999,
as revised February 29, 2000

Putnam Health Sciences Trust

Class Y shares

Investment Category: Growth
This prospectus explains what you should know about this mutual fund
before you invest. Please read it carefully.

Putnam Investment Management, Inc. (Putnam Management), which has managed
mutual funds since 1937, manages the fund.

These securities have not been approved or disapproved by the Securities
and Exchange Commission nor has the Commission passed upon the accuracy or
adequacy of this prospectus. Any statement to the contrary is a crime.


    CONTENTS

 2  Fund summary

 2  Goal

 2  Main investment strategies

 2  Main risks

 3  Performance information

 4  Fees and expenses

 4  What are the fund's main investment strategies and related risks?

 6  Who manages the fund?

 7  How does the fund price its shares?

 8  How do I buy fund shares?

 8  How do I sell fund shares?

 9  How do I exchange fund shares?

 9  Fund distributions and taxes

Putnam Defined Contribution Plans



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Fund summary

GOAL

The fund seeks capital appreciation.

MAIN INVESTMENT STRATEGIES -- GROWTH STOCKS

We invest mainly in common stocks of U.S. companies in the health sciences
industries, with a focus on growth stocks. Growth stocks are issued by
companies whose earnings we believe are likely to grow faster than the
economy as a whole. Growth in a company's earnings may lead to an increase
in the price of its stock. We invest mainly in midsized and large
companies.

MAIN RISKS

The main risks that could adversely affect the value of the fund's shares
and the total return on your investment include:

* The risk that the stock price of one or more of the companies in the
  fund's portfolio will fall, or will fail to rise. Many factors can
  adversely affect a stock's performance, including both general financial
  market conditions and factors related to a specific company or industry.
  This risk is generally greater for small and midsized companies, which tend
  to be more vulnerable to adverse developments.

* The risk that movements in financial markets will adversely affect the
  price of the fund's investments, regardless of how well the companies in
  which we invest perform. The market as a whole may not favor the types of
  investments we make.

* The risk of investing in a single group of industries. Investments in the
  health sciences industries, even though representing interests in different
  companies within these industries, may be affected by common economic
  forces and other factors. This vulnerability to factors affecting the
  health sciences industries is significantly greater than for a fund that
  invests in a broader range of industries, and may result in greater fund
  losses and volatility.

* The risk of loss from investing in fewer issuers than a fund that invests
  more broadly. The fund is "non-diversified," which means that it may invest
  more of its assets in the securities of fewer companies than a
  "diversified" fund. This vulnerability to factors affecting a single
  investment can result in greater fund losses and volatility.

You can lose money by investing in the fund. The fund may not achieve its
goals, and is not intended as a complete investment program. An investment
in the fund is not a deposit in a bank and is not insured or guaranteed by
the Federal Deposit Insurance Corporation or any other government agency.

PERFORMANCE INFORMATION

The following information provides some indication of the fund's risks. The
chart shows year-to-year changes in the performance of the fund's class Y
shares. The table following the chart compares the fund's performance to
that of a broad measure of market performance. Of course, the fund's past
performance is not an indication of future performance.


[GRAPHIC OMITTED: vertical bar chart CALENDAR YEAR TOTAL RETURNS]
CALENDAR YEAR TOTAL RETURNS
Plot points

1989    41.98%
1990    15.51%
1991    49.07%
1992   -10.70%
1993    -0.04%
1994    15.16%
1995    47.00%
1996    12.43%
1997    32.37%
1998    27.10%

Year-to-date performance through 9/30/99 was 16.15%. During the periods
shown in the bar chart, the highest return for a quarter was 21.49%
(quarter ending 3/31/91) and the lowest return for a quarter was -12.12%
(quarter ending 3/31/92).

Performance of class Y shares, which were not in existence during the
period, in the bar chart and table following the chart, is derived from the
historical performance of class A shares (not offered by this prospectus).
Performance of class Y shares does not reflect the initial sales charge
currently applicable to class A shares or differences in operating expenses
which, for class Y shares, are lower than the operating expenses applicable
to class A shares.

- -------------------------------------------------------------------------------
Average Annual Total Returns (for periods ending 12/31/98)
- -------------------------------------------------------------------------------

                                                  Past      Past      Past
                                                  1 year    5 years   10 years
- -------------------------------------------------------------------------------
Class Y                                           19.79%    24.72%    20.75%
S&P 500 Index                                     28.58%    24.07%    19.21%
- -------------------------------------------------------------------------------

The fund's performance is compared to the Standard & Poor's 500 Index, an
unmanaged index of common stocks frequently used as a general measure of
U.S. stock market performance.

FEES AND EXPENSES

This table summarizes the expenses you may pay if you buy and hold class Y
shares of the fund. Expenses are based on the fund's last fiscal year.

- -------------------------------------------------------------------------------
Annual Fund Operating Expenses
(expenses that are deducted from fund assets)
- -------------------------------------------------------------------------------

                                                             Total Annual
                                    Management   Other       Fund Operating
                                    Fees         Expenses    Expenses
- -------------------------------------------------------------------------------
Class Y                             0.54%        0.16%       0.70%
- -------------------------------------------------------------------------------


EXAMPLE

The example translates the expenses shown in the preceding table into
dollar amounts. By doing this, you can more easily compare the cost of
investing in the fund to the cost of investing in other mutual funds. The
example makes certain assumptions. It assumes that you invest $10,000 in
the fund for the time periods shown and then redeem all your shares at the
end of those periods. It also assumes a 5% return on your investment each
year and that the fund's operating expenses remain the same. The example is
hypothetical; your actual costs and returns may be higher or lower.

- -------------------------------------------------------------------------------
                       1 year       3 years       5 years      10 years
- -------------------------------------------------------------------------------
Class Y                $72          $224          $390          $871
- -------------------------------------------------------------------------------

What are the fund's main investment strategies and  related risks?

Any investment carries with it some level of risk that generally reflects
its potential for reward. We pursue the fund's goal by investing mainly in
growth stocks of companies in the health sciences industries. We will
consider, among other things, a company's financial strength, competitive
position in its industry, projected future earnings, cash flows and
dividends when deciding whether to buy or sell investments. A description
of the risks associated with the fund's main investment strategies follows.

* Common stocks. Common stock represents an ownership interest in a
  company. The value of a company's stock may fall as a result of factors
  relating directly to that company, such as decisions made by its management
  or lower demand for the company's products or services. A stock's value may
  also fall because of factors affecting not just the company, but also
  companies in the same industry or in a number of different industries, such
  as increases in production costs. The value of a company's stock may also
  be affected by changes in financial markets that are relatively unrelated
  to the company or its industry, such as changes in interest rates or
  currency exchange rates. In addition, a company's stock generally pays
  dividends only after the company invests in its own business and makes
  required payments to holders of its bonds and other debt. For this reason,
  the value of a company's stock will usually react more strongly than bonds
  and other debt to actual or perceived changes in the company's financial
  condition or prospects. Stocks of smaller companies may be more vulnerable
  to adverse developments than those of larger companies.

* Growth stocks. These are stocks of companies whose earnings we believe
  are likely to grow faster than the economy as a whole. Growth stocks
  typically trade at higher multiples of current earnings than other stocks.
  Therefore, the values of growth stocks may be more sensitive to changes in
  current or expected earnings than the values of other stocks. If our
  assessment of the prospects for a company's earnings growth is wrong, or if
  our judgment of how other investors will value the company's earnings
  growth is wrong, then the price of the company's stock may fall or not
  approach the value that we have placed on it.

* Foreign investments. We may invest in securities of foreign issuers.
  Foreign investments involve certain special risks. For example, their
  values may decline in response to changes in currency exchange rates,
  unfavorable political and legal developments, unreliable or untimely
  information, and economic and financial instability. In addition, the
  liquidity of these investments may be more limited than for U.S.
  investments, which means we may at times be unable to sell them at
  desirable prices. Foreign settlement procedures may also involve additional
  risks. These risks are generally greater in the case of developing (also
  known as emerging) markets with less developed legal and financial systems.

Certain of these risks may also apply to U.S. investments that are
denominated in foreign currencies or that are traded in foreign markets, or
to securities of U.S. companies that have significant foreign operations.

* Smaller companies. We may invest in smaller and midsized companies.
  Smaller companies, which may have a market capitalization of less than $1
  billion, are more likely than larger companies to have limited product
  lines, markets or financial resources, or to depend on a small,
  inexperienced management group. Stocks of these companies often trade less
  frequently and in limited volume, and their prices may fluctuate more than
  stocks of larger companies. Stocks of smaller and midsized companies may
  therefore be more vulnerable to adverse developments than those of larger
  companies.

* Industry focus. We invest primarily in companies that provide health care
  services, applied research and development, pharmaceutical products, and
  medical equipment and supplies, and companies that we believe will grow as
  a result of their products, patents or other market advantages in the
  health sciences industries. Events that affect the health sciences
  industries will have a greater effect on the fund than they would on a fund
  that is more widely diversified among a number of unrelated industries.
  Examples include technological advances that make existing products and
  services obsolete, and changes in regulatory policies concerning approvals
  of new drugs, medical devices or procedures. In addition, changes in
  governmental payment systems and use of managed care arrangements may be
  more likely to adversely affect the fund.

* Other investments. In addition to the main investment strategies
  described above, we may make other investments, such as investments in
  preferred stocks, convertible securities, debt instruments and derivatives,
  which may be subject to other risks, as described in the fund's statement
  of additional information (SAI).

* Alternative strategies. At times we may judge that market conditions make
  pursuing the fund's usual investment strategies inconsistent with the best
  interests of the fund's shareholders. We then may temporarily use
  alternative strategies that are mainly designed to limit losses. However,
  we may choose not to use these strategies for a variety of reasons, even in
  very volatile market conditions. These strategies may cause the fund to
  miss out on investment opportunities, and may prevent the fund from
  achieving its goal.

* Changes in policies. The fund's Trustees may change the fund's goal,
  investment strategies and other policies without shareholder approval,
  except as otherwise indicated.

Who manages the fund?

The fund's Trustees oversee the general conduct of the fund's business. The
Trustees have retained Putnam Management to be the fund's investment
manager, responsible for making investment decisions for the fund and
managing the fund's other affairs and business. The fund pays Putnam
Management a quarterly management fee for these services based on the
fund's average net assets. The fund paid Putnam Management a management fee
of 0.54% of average net assets for the fund's last fiscal year. Putnam
Management's address is One Post Office Square, Boston, MA 02109.

The following officers of Putnam Management have had primary responsibility
for the day-to-day management of the fund's portfolio since the years shown
below. Their experience as portfolio managers or investment analysts over
at least the last five years is also shown


<TABLE>
<CAPTION>

- -------------------------------------------------------------------------------
<S>                        <C>      <C>               <C>
Manager                     Since    Experience
- -------------------------------------------------------------------------------
David G. Carlson            1997     1990 - Present    Putnam Management
Senior Vice President
- -------------------------------------------------------------------------------
Richard B. England          1997     1992 - Present    Putnam Management
Senior Vice President
- -------------------------------------------------------------------------------
Margery C. Parker           1998     1997 - Present    Putnam Management
Senior Vice President                Prior to 1997     Keystone Investments
- -------------------------------------------------------------------------------

</TABLE>

* Year 2000 issues. The fund could be adversely affected if the computer
  systems that we and the fund's other service providers use do not properly
  process and calculate date-related information relating to the year 2000.
  While year 2000-related computer problems could have a negative effect on
  the fund, both in its operations and in its investments, we are working to
  avoid such problems and to obtain assurances from the fund's service
  providers that they are taking similar steps. No assurances, though, can be
  provided that the fund will not be adversely impacted by these matters.

How does the fund price its shares?

The price of the fund's shares is based on its net asset value (NAV). The
NAV per share of each class equals the total value of its assets, less its
liabilities, divided by the number of its outstanding shares. Shares are
only valued as of the close of regular trading on the New York Stock
Exchange each day the exchange is open.

The fund values its investments for which market quotations are readily
available at market value. It values short-term investments that will
mature within 60 days at amortized cost, which approximates market value.
It values all other investments and assets at their fair value.

The fund translates prices for its investments quoted in foreign currencies
into U.S. dollars at current exchange rates. As a result, changes in the
value of those currencies in relation to the U.S. dollar may affect the
fund's NAV. Because foreign markets may be open at different times than the
New York Stock Exchange, the value of the fund's shares may change on days
when shareholders are not able to buy or sell them. If events materially
affecting the values of the fund's foreign investments occur between the
close of foreign markets and the close of regular trading on the New York
Stock Exchange, these investments will be valued at their fair value.

How do I buy fund shares?

All orders to purchase shares must be made through your employer's
retirement plan. For more information about how to purchase shares of the
fund through your employer's plan or limitations on the amount that may be
purchased, please consult your employer.

Putnam Mutual Funds Corp. (Putnam Mutual Funds) generally must receive your
plan's completed buy order before the close of regular trading on the New
York Stock Exchange for shares to be bought at that day's offering price.

To eliminate the need for safekeeping, the fund will not issue certificates
for shares.

The fund may periodically close to new purchases of shares or refuse any
order to buy shares if Putnam Management determines that doing so would be
in the best interests of the fund and its shareholders.

* Eligible purchasers. A defined contribution plan (including a corporate
  IRA) is eligible to purchase class Y shares if

* the plan, its sponsor and other employee benefit plans of the sponsor
  invest at least $150 million in Putnam funds and other investments managed
  by Putnam Management or its affiliates, or

* the plan's sponsor confirms a good faith expectation that investments in
  Putnam-managed assets by the sponsor and its employee benefit plans will
  attain $150 million (using the higher of purchase price or current market
  value) within one year of initial purchase, and agrees that class Y shares
  may be redeemed and class A shares purchased if that level is not attained.

How do I sell fund shares?

Subject to any restrictions imposed by your employer's plan, you can sell
your shares through the plan back to the fund any day the New York Stock
Exchange is open. For more information about how to sell shares of the fund
through your employer's plan, including any charges that the plan may
impose, please consult your employer.

Your plan administrator must send a signed letter of instruction to Putnam
Investor Services. The price you will receive is the next NAV per share
calculated after the fund receives the instruction in proper form. In order
to receive that day's NAV, Putnam Investor Services must receive the
instruction before the close of regular trading on the New York Stock
Exchange.

The fund generally sends payment for your shares the business day after
your request is received. Under unusual circumstances, the fund may suspend
redemptions, or postpone payment for more than seven days, as permitted by
federal securities law.

How do I exchange fund shares?

Subject to any restrictions your plan imposes, you can exchange your fund
shares for shares of other Putnam funds offered through your employer's
plan without a sales charge. Contact your plan administrator or Putnam
Investor Services for more information.

The exchange privilege is not intended as a vehicle for short-term trading.
Excessive exchange activity may interfere with portfolio management and
have an adverse effect on all shareholders. In order to limit excessive
exchange activity and otherwise to promote the best interests of the fund,
the fund reserves the right to revise or terminate the exchange privilege,
limit the amount or number of exchanges or reject any exchange. The fund
into which you would like to exchange may also reject your exchange. These
actions may apply to all shareholders or only to those shareholders whose
exchanges Putnam Management determines are likely to have a negative effect
on the fund or other Putnam funds.

Fund distributions and taxes

The fund distributes any net investment income and any net realized capital
gains at least once a year.

The terms of your employer's plan will govern how your employer's plan may
receive distributions from the fund. Generally, periodic distributions from
the fund to your employer's plan are reinvested in additional fund shares,
although your employer's plan may permit you to receive fund distributions
from net investment income in cash while reinvesting capital gains
distributions in additional shares or to receive all fund distributions in
cash. If another option is not selected, all distributions will be
reinvested in additional fund shares.

Generally, for federal income tax purposes, fund distributions are taxable
as ordinary income, except that any distributions of long-term capital
gains will be taxed as such regardless of how long you have held your
shares. However, distributions by the fund to retirement plans that qualify
for tax-exempt treatment under federal income tax laws will not be taxable.
Special tax rules apply to investments through such plans. You should
consult your tax advisor to determine the suitability of the fund as an
investment through such a plan and the tax treatment of distributions
(including distributions of amounts attributable to an investment in the
fund) from such a plan.

The fund's investments in foreign securities may be subject to foreign
withholding taxes. In that case, the fund's return on those investments
would be decreased.

You should consult your tax advisor for more information on your own tax
situation, including possible foreign, state and local taxes.

[This page left intentionally blank]


For more information
about Putnam Health
Sciences Trust

The fund's statement of additional information (SAI) and annual and
semi-annual reports to shareholders include additional information about
the fund. The SAI, and the independent accountant's report and financial
statements included in the fund's most recent annual report to its
shareholders, are incorporated by reference into this prospectus, which
means they are part of this prospectus for legal purposes. The fund's
annual report discusses the market conditions and investment strategies
that significantly affected the fund's performance during its last fiscal
year. You may get free copies of these materials, request other
information about the fund, or make shareholder inquiries, by calling Putnam
toll-free at 1-800-752-9894.

You may review and copy information about the fund, including its SAI, at
the Securities and Exchange Commission's public reference room in
Washington, D.C. You may call the Commission at 1-800-SEC-0330 for
information about the operation of the public reference room. You may also
access reports and other information about the fund on the Commission's
Internet site at http://www.sec.gov. You may get copies of this
information, with payment of a duplication fee, by writing the Public
Reference Section of the Commission, Washington, D.C. 20549-6009. You may
need to refer to the fund's file number.


P U T N A M  I N V E S T M E N T S

             Putnam Defined Contribution Plans

             One Post Office Square
             Boston, Massachusetts 02109

             1-800-752-9894


             Address correspondence to
             Putnam Investor Services
             P.O. Box 989
             Boston, Massachusetts 02103

             www.putnaminv.com

58892 2/00   File No. 811-3386




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