GENERAL AMERICAN INVESTORS CO INC
SC 13G/A, 1996-02-09
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SCHEDULE 13G

Amendment No. 2
Applied Bioscience International Inc.
Common Stock
Cusip # 037917101
Filing Fee:  No

Cusip # 037917101
Item 1:           Reporting Person - General American Investors Company,
Inc. - (Tax ID:  13-5098450)
Item 4:           Delaware
Item 5:           1,036,000
Item 6:           0
Item 7:           1,056,084
Item 8:           0
Item 9:           1,056,084
Item 11:          less than 5%
Item 12:          IV and IA

SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE
13d-1(b) or 13d-2(b)

Item 1(a).          Name of Issuer:

          Applied Bioscience International Inc.

Item 1(b).          Address of Issuer's Principal Executive Offices:

          4350 North Fairfax Drive
          Arlington, VA  22203-1627

Item 2(a).          Name of Person Filing:

          General American Investors Company, Inc.

Item 2(b).          Address or Principal Business Office or, if none, Residence:

          450 Lexington Avenue
          New York, NY  10017

Item 2(c).          Citizenship:

          Delaware Corporation

Item 2(d).          Title of Class of Securities:

          Common Stock, $.01 Par Value

Item 2(e).          CUSIP Number:

          037917101

Item 3. This statement is filed pursuant to Rules 13d-1(b), or 13d-2(b), and the
person  filing  is an:  Investment  Company  registered  under  section 8 of the
Investment Company Act of 1940 and Investment Adviser registered under section
203 of the Investment  Advisers Act of 1940.

Item 4(a).          Amount Beneficially Owned:

          1,056,084

Item 4(b).          Percent of Class:

          less than 5%

Item 4(c).          Number of shares as to which such person has:

         (i)       sole power to vote or to direct the vote
                         1,036,000
         (ii)      shares power to vote or to direct the vote
                            0
         (iii)     sole power to dispose or to direct the disposition of
                         1,056,084
         (iv)      shared power to dispose or to direct the disposition of
                            0

Item 5.             Ownership of Five Percent or Less of a Class.

          Not applicable.

Item 6.             Ownership of More than Five Percent on Behalf of Another
                    Person.

          Not Applicable.

Item 7.             Identification and Classification of the Subsidiary Which
                    Acquired the Security Being Reported on By the
                    Parent Holding Company.

          Not Applicable.

Item 8.             Identification and Classification of Members of the Group.

          Not Applicable.

Item 9.             Notice of Dissolution of Group.

          Not Applicable.

Item 10.            Certification.

         By  signing  below I  certify  that,  to the best of my  knowledge  and
belief, the securities referred to above were acquired in the ordinary course of
business  and were not acquired for the purpose of and do not have the effect of
changing or  influencing  the control of the issuer of such  securities and were
not acquired in connection  with or as a participant in any  transaction  having
such purposes or effect.

Signature.

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


         February 9, 1996
Date


         /s/Eugene L. DeStaebler, Jr.
Signature



         Eugene L. DeStaebler, Jr.
         Vice-President, Administration
Name/Title



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