ALZA CORP
S-3/A, 1994-06-20
PHARMACEUTICAL PREPARATIONS
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<PAGE>
   
     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JUNE 20, 1994
    
   
                                                       REGISTRATION NO. 33-53671
    
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------

   
                                AMENDMENT NO. 1
                                       TO
                                    FORM S-3
    
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------

                                ALZA CORPORATION
             (Exact name of registrant as specified in its charter)

<TABLE>
<S>                          <C>
         DELAWARE               77-0142070
      (State or other        (I.R.S. Employer
      jurisdiction of         Identification
     incorporation or              No.)
       organization)
</TABLE>

                       950 Page Mill Road, P.O. Box 10950
                        Palo Alto, California 94303-0802
                                 (415) 494-5000
         (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)

                                BRUCE C. COZADD
                   Vice President and Chief Financial Officer
                                ALZA Corporation
                       950 Page Mill Road, P.O. Box 10950
                        Palo Alto, California 94303-0802
                                 (415) 494-5000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                            ------------------------

           WITH COPIES OF ALL ORDERS, NOTICES AND COMMUNICATIONS TO:

<TABLE>
<S>                                 <C>
      SARAH A. O'DOWD, Esq.            WILLIAM H. HINMAN, JR., Esq.
Heller, Ehrman, White & McAuliffe          Shearman & Sterling
      525 University Avenue               555 California Street
       Palo Alto, CA 94301               San Francisco, CA 94104
          (415) 324-7000                      (415) 616-1100
</TABLE>

                            ------------------------

        APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.
                            ------------------------

    If any of the securities on this Form are being offered pursuant to dividend
or interest reinvestment plans, check the following box. / /

   
    If  any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to  Rule 415 under the Securities Act  of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. / /
    
                            ------------------------

   
    THE  REGISTRANT HEREBY  AMENDS THIS REGISTRATION  STATEMENT ON  SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A  FURTHER  AMENDMENT  WHICH SPECIFICALLY  STATES  THAT  THIS  REGISTRATION
STATEMENT  SHALL THEREAFTER BECOME EFFECTIVE IN  ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT  OF 1933 OR  UNTIL THIS REGISTRATION  STATEMENT SHALL  BECOME
EFFECTIVE  ON  SUCH  DATE  AS THE  SECURITIES  AND  EXCHANGE  COMMISSION, ACTING
PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.
    

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
INFORMATION   CONTAINED  HEREIN  IS  SUBJECT   TO  COMPLETION  OR  AMENDMENT.  A
REGISTRATION STATEMENT  RELATING TO  THESE SECURITIES  HAS BEEN  FILED WITH  THE
SECURITIES  AND EXCHANGE  COMMISSION. THESE SECURITIES  MAY NOT BE  SOLD NOR MAY
OFFERS TO BUY BE ACCEPTED PRIOR  TO THE TIME THE REGISTRATION STATEMENT  BECOMES
EFFECTIVE.  THIS  PROSPECTUS  SHALL  NOT  CONSTITUTE AN  OFFER  TO  SELL  OR THE
SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE  SECURITIES
IN  ANY STATE IN WHICH SUCH OFFER,  SOLICITATION OR SALE WOULD BE UNLAWFUL PRIOR
TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS OF ANY SUCH STATE.
<PAGE>
   
                             SUBJECT TO COMPLETION
                   PRELIMINARY PROSPECTUS DATED JUNE 20, 1994
    
P R O S P E C T U S
                                  $825,000,000

                                     [LOGO]
                     LIQUID YIELD OPTION-TM- NOTES DUE 2014
                          (ZERO COUPON--SUBORDINATED)
                               ------------------

   
    The issue price  of each  Liquid Yield  Option-TM- Note  ("LYON"-TM-) to  be
issued  by ALZA Corporation, a Delaware corporation ("ALZA"), will be  $
(    % of principal amount  at maturity) (the "Issue Price"), and there will  be
no  periodic payments of interest. The  LYONs will mature on July    , 2014. The
Issue Price of  each LYON represents  a yield to  maturity of       % per  annum
(computed on a semi-annual bond equivalent basis) calculated from July   , 1994.
The LYONs will be subordinated to all existing and future Senior Indebtedness of
ALZA,  the  principal amount  of  which as  of May  31,  1994 was  $1.7 million,
excluding ALZA's  $249.3  million  principal amount  of  outstanding  commercial
paper, which will be retired with a portion of the proceeds from the sale of the
LYONs.  See  "Capitalization"  and  "Description of  LYONs  --  Subordination of
LYONs."
    

   
    Each LYON will be convertible at the option of the Holder at any time on  or
prior  to maturity, unless  previously redeemed or  otherwise purchased by ALZA.
Upon conversion, ALZA  may elect  to deliver Common  Stock, par  value $.01  per
share  (the "Common Stock"), of ALZA at a conversion rate of          shares per
LYON (the "Conversion Rate") or cash equal to the market value of the shares  of
Common  Stock into which the LYONs are convertible. The Conversion Rate will not
be adjusted  for  accrued  Original  Issue Discount,  but  will  be  subject  to
adjustment  upon the  occurrence of certain  events affecting  the Common Stock.
Upon conversion,  the Holder  will  not receive  any cash  payment  representing
accrued  Original Issue Discount;  such accrued Original  Issue Discount will be
deemed paid by the Common Stock or cash received on conversion. See "Description
of LYONs -- Conversion Rights." On June  16, 1994, the last reported sale  price
of the Common Stock on the New York Stock Exchange was $26 1/4 per share.
    

   
    LYONs will be purchased by ALZA, at the option of the Holder, as of July   ,
1999,  July   , 2004 and July    , 2009 (each, a "Purchase Date") for a Purchase
Price per LYON of $         , $         and $         (Issue Price plus  accrued
Original  Issue Discount  to such  Purchase Date),  respectively, representing a
yield per annum to the Holder on each such Purchase Date of    % (computed on  a
semi-annual  bond equivalent basis). Subject to certain conditions, ALZA, at its
option, may elect to pay the Purchase  Price as of any particular Purchase  Date
in  cash  or  shares  of  Common  Stock,  or  in  any  combination  thereof. See
"Description of LYONs  -- Purchase of  LYONs at  the Option of  the Holder."  In
addition,  as of 35 business days after  the occurrence of any Change in Control
of ALZA occurring on or prior to July   , 1999, ALZA will also purchase for cash
any LYON, at the option  of the Holder, for a  Change in Control Purchase  Price
equal  to the Issue Price  plus accrued Original Issue  Discount to the date set
for such  purchase. See  "Description  of LYONs  --  Change in  Control  Permits
Purchase of LYONs at the Option of the Holder."
    

   
    The LYONs will not be redeemable by ALZA prior to July   , 1999. Thereafter,
the LYONs are redeemable for cash at any time at the option of ALZA, in whole or
in  part, at Redemption  Prices equal to  the Issue Price  plus accrued Original
Issue Discount  to  the  date  of  redemption.  See  "Description  of  LYONs  --
Redemption of LYONs at the Option of ALZA."
    

    For  a discussion of certain United States federal income tax considerations
for  Holders  of  LYONs,   see  "Certain  United   States  Federal  Income   Tax
Considerations."

    Application has been made to list the LYONs on the New York Stock Exchange.

   
    SEE  "INVESTMENT CONSIDERATIONS" FOR  A DISCUSSION OF  CERTAIN FACTORS WHICH
SHOULD BE CAREFULLY CONSIDERED  BY PROSPECTIVE PURCHASERS  OF THE LYONS  OFFERED
HEREBY.
    
                           --------------------------

THESE  SECURITIES  HAVE  NOT  BEEN APPROVED  OR  DISAPPROVED  BY  THE SECURITIES
  AND  EXCHANGE  COMMISSION  OR  ANY  STATE  SECURITIES  COMMISSION,  NOR  HAS
    THE   SECURITIES  AND  EXCHANGE  COMMISSION   OR  ANY  STATE  SECURITIES
      COMMISSION  PASSED   UPON  THE   ACCURACY   OR  ADEQUACY   OF   THIS
       PROSPECTUS.  ANY  REPRESENTATION  TO THE  CONTRARY  IS  A CRIMINAL
                                    OFFENSE.

<TABLE>
<CAPTION>
                                             PRINCIPAL AMOUNT        PRICE TO          UNDERWRITING        PROCEEDS TO
                                               AT MATURITY            PUBLIC           DISCOUNT (1)          ALZA (2)
<S>                                         <C>                 <C>                 <C>                 <C>
Per LYON..................................         100%                 %                   %                   %
Total (3).................................     $825,000,000             $                   $                   $
<FN>
(1)  ALZA has agreed to indemnify  the Underwriter against certain  liabilities,
     including  liabilities under  the Securities Act  of 1933,  as amended. See
     "Underwriting."
(2)  Before deducting expenses payable by ALZA estimated at $400,000.
(3)  ALZA has  granted the  Underwriter an  option, exercisable  within 30  days
     after  the  date  of  this  Prospectus, to  purchase  up  to  an additional
     $123,750,000 aggregate principal amount  at maturity of  LYONs on the  same
     terms as set forth above to cover over-allotments, if any. If the option is
     exercised in full, the total Principal Amount at Maturity, Price to Public,
     Underwriting   Discount  and   Proceeds  to  ALZA   will  be  $948,750,000,
     $               , $               and  $               , respectively.  See
     "Underwriting."
</TABLE>

                           --------------------------

   
    The  LYONs are offered by  the Underwriter, subject to  prior sale, when, as
and if delivered  to and  accepted by the  Underwriter, subject  to approval  of
certain  legal  matters  by  counsel  for  the  Underwriter  and  certain  other
conditions. The Underwriter  reserves the  right to withdraw,  cancel or  modify
such  offer  and to  reject orders  in whole  or  in part.  It is  expected that
delivery of the LYONs will be made in New  York, New York, on or about July    ,
1994.
    
- -TM- Trademark of Merrill Lynch & Co., Inc.
                           --------------------------
                              MERRILL LYNCH & CO.
                                ---------------

                 The date of this Prospectus is June   , 1994.
<PAGE>
    IN  CONNECTION WITH THIS OFFERING, THE  UNDERWRITER MAY OVER-ALLOT OR EFFECT
TRANSACTIONS WHICH STABILIZE OR MAINTAIN THE  MARKET PRICE OF THE LYONS  OFFERED
HEREBY OR THE COMMON STOCK OF ALZA, OR BOTH OF THEM, AT LEVELS ABOVE THOSE WHICH
MIGHT OTHERWISE PREVAIL IN THE OPEN MARKET. SUCH TRANSACTIONS MAY BE EFFECTED ON
THE  NEW YORK STOCK EXCHANGE, IN  THE OVER-THE-COUNTER MARKET OR OTHERWISE. SUCH
STABILIZING, IF COMMENCED, MAY BE DISCONTINUED AT ANY TIME.
                            ------------------------

                             AVAILABLE INFORMATION

    ALZA is subject to the informational requirements of the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), and in accordance therewith  files
reports, proxy statements and other information with the Securities and Exchange
Commission   (the  "Commission").  Such  reports,  proxy  statements  and  other
information  may  be  inspected  at  the  public  reference  facilities  of  the
Commission  at Judiciary Plaza, 450 Fifth  Street, N.W., Washington, D.C. 20549.
Copies of such material can be obtained at prescribed rates from the  Commission
at  such address. Such reports, proxy  statements and other information can also
be inspected at the Commission's regional offices at 7 World Trade Center,  13th
Floor,  New York,  New York 10048  and at  500 West Madison  Street, Suite 1400,
Chicago, Illinois 60661. In addition,  such reports, proxy statements and  other
information  concerning ALZA  may be  inspected at the  offices of  the New York
Stock Exchange at 20 Broad Street, New York, New York 10005.

    ALZA has filed  with the  Commission a  Registration Statement  on Form  S-3
under  the  Securities Act  of  1933, as  amended  (the "Securities  Act"), with
respect to the securities offered by this Prospectus. As permitted by the  rules
and  regulations of the Commission, this Prospectus  does not contain all of the
information set  forth  in  the  Registration Statement  and  the  exhibits  and
schedules  thereto.  For  further  information  with  respect  to  ALZA  and the
securities offered hereby, reference is  made to the Registration Statement  and
the  exhibits  thereto,  which may  be  examined  without charge  at  the public
reference facilities maintained by the Commission at Judiciary Plaza, 450  Fifth
Street,  N.W., Washington, D.C. 20549, and copies  of which may be obtained from
the Commission upon payment of the prescribed fees.

                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

    The following documents, which have been filed by ALZA with the  Commission,
are hereby incorporated by reference in this Prospectus:

        (a) ALZA's Annual Report on Form 10-K for the fiscal year ended December
    31, 1993;

        (b) ALZA's Quarterly Report on Form 10-Q for the quarter ended March 31,
    1994; and

        (c) The description of the Common Stock contained in ALZA's registration
    statement  on Form 8-A filed May 14,  1992 under the Exchange Act, including
    any amendment or reports filed for the purpose of updating such description.

    All documents filed by ALZA pursuant to Section 13(a), 13(c), 14 or 15(d) of
the Exchange Act  subsequent to the  date of  this Prospectus and  prior to  the
termination  of the offering of the securities offered hereby shall be deemed to
be incorporated by reference into this Prospectus  and to be a part hereof  from
the  respective dates of filing of such  documents. Any statement contained in a
document incorporated or deemed to be incorporated by reference herein shall  be
deemed  to be  modified or  superseded for  purposes of  this Prospectus  to the
extent that a  statement contained herein,  or in any  other subsequently  filed
document  that also  is or  is deemed  to be  incorporated by  reference herein,
modifies or  supersedes  such  statement.  Any such  statement  so  modified  or
superseded  shall  not  be  deemed,  except as  so  modified  or  superseded, to
constitute a part of this Prospectus.

    Upon written or oral request  directed to Corporate and Investor  Relations,
ALZA  Corporation, 950  Page Mill  Road, P.O.  Box 10950,  Palo Alto, California
94303-0802, telephone (415) 494-5222, ALZA will provide, without charge, to  any
person to whom this Prospectus is delivered, a copy of any document incorporated
by  reference in  this Prospectus (not  including exhibits to  any such document
except to  the  extent  any  such  exhibits  are  specifically  incorporated  by
reference in the information incorporated in this Prospectus).

                                       2
<PAGE>
                               PROSPECTUS SUMMARY

    THE FOLLOWING SUMMARY IS QUALIFIED BY THE DETAILED INFORMATION AND FINANCIAL
STATEMENTS  INCLUDED ELSEWHERE OR INCORPORATED  BY REFERENCE IN THIS PROSPECTUS.
UNLESS OTHERWISE INDICATED, THE INFORMATION IN THIS PROSPECTUS ASSUMES THAT  THE
UNDERWRITER'S OVER-ALLOTMENT OPTION IS NOT EXERCISED.

                                      ALZA

   
    ALZA  is the recognized leader in the development of pharmaceutical products
based on controlled drug delivery technologies. Since the company's founding  in
1968,  ALZA's research and development efforts have resulted in a broad range of
proprietary therapeutic systems designed to  improve the medical value and  cost
effectiveness  of drug compounds by  improving efficacy, minimizing side effects
and/or providing greater patient  compliance. Among the ALZA-developed  products
commercialized  to  date  by  client  companies  are  Procardia  XL-R-,  for the
treatment  of   both  angina   and  hypertension,   Volmax-R-  (albuterol),   an
anti-asthmatic product, and Efidac/24-R-, an over-the-counter nasal decongestant
product,   all   utilizing  ALZA's   OROS-R-   oral  therapeutic   systems;  and
Transderm-Nitro-R- for the prevention and  treatment of angina, Nicoderm-R-,  an
aid  in smoking cessation,  and Duragesic-R- for the  management of chronic pain
(such as  cancer  pain),  utilizing  various  transdermal  therapeutic  systems.
Approximately  60 additional products utilizing  ALZA therapeutic systems are in
various stages of  development or  clinical evaluation,  a number  of which  are
awaiting  marketing clearance in the United  States and/or other countries. ALZA
recently announced United States Food and Drug Administration ("FDA")  marketing
clearance  of two products -- Glucotrol XL-R- and Actisite-R- (tetracycline HCl)
periodontal fiber. Glucotrol XL-R-,  developed jointly with  Pfizer, Inc., is  a
product  for the  treatment of  diabetes taken  orally once  a day. Actisite-R-,
developed   jointly   with   On-Site   Therapeutics,   Inc.,   is   the    first
sustained-release,  site-specific  drug  therapy cleared  for  marketing  in the
United States for the treatment of patients with adult periodontitis.
    

    Most of ALZA's product development activities have been undertaken  pursuant
to joint development and commercialization agreements, including agreements with
many  of the world's largest pharmaceutical companies. These agreements normally
provide for the pharmaceutical company client to reimburse ALZA for ALZA's costs
incurred in product  development and  clinical evaluation.  The client  receives
marketing  rights to the products and  ALZA receives royalties on product sales.
In some cases,  ALZA has rights  to co-promote the  products developed. In  many
cases,  ALZA manufactures all or  a portion of the  client's requirements of the
product. ALZA's  clients  often  take  responsibility  for  obtaining  necessary
regulatory   approvals  and  make  all  marketing  and  other  commercialization
decisions regarding the products. Therefore,  most of the variables that  affect
ALZA's  royalties and  fees are  not within ALZA's  control. For  the year ended
December  31,  1993,  royalties  from  sales  of  Procardia  XL  accounted   for
approximately 60% of ALZA's royalties and fees.

    As  part  of ALZA's  Target 2000  strategic plan,  ALZA intends  to increase
significantly the development, manufacturing and  marketing of its own  products
in  addition to  continuing its  client-based business.  In furtherance  of this
goal, ALZA  formed Therapeutic  Discovery  Corporation ("TDC")  and  distributed
"units,"  consisting of TDC shares  and ALZA warrants, as  a special dividend to
ALZA stockholders in  June 1993. TDC  was formed to  develop and  commercialize,
most  likely  through  licensing  to ALZA,  products  incorporating  ALZA's drug
delivery systems with various drug  compounds. ALZA contributed $250 million  in
cash  to TDC  and will  develop products  on behalf  of TDC  under a development
contract. ALZA has an option to license each product developed by TDC, and  also
has  an option to purchase all of the  TDC shares. The formation of TDC, and the
development of products with TDC, are intended to result in a potential pipeline
of products for marketing by ALZA.

    With the approval  and launch  of the  Testoderm-R- transdermal  therapeutic
system for the treatment of testosterone deficiencies in hypogonadal males, ALZA
has  begun to accelerate its marketing activities. ALZA introduced the Testoderm
product in the United States in April 1994 through ALZA Pharmaceuticals,  ALZA's
sales and marketing group. ALZA Pharmaceuticals also has begun to co-promote the
Duragesic  transdermal  fentanyl  system with  Janssen  Pharmaceutica.  With the
Testoderm product, the

                                       3
<PAGE>
   
Duragesic co-promotion  activities,  other  co-promotion  arrangements  and  the
opportunity  to market the  products developed by TDC,  ALZA intends to increase
its commercialization activities through  ALZA Pharmaceuticals while  continuing
its business of developing products for third party clients.
    

    ALZA's  principal executive offices are located  at 950 Page Mill Road, P.O.
Box 10950, Palo Alto,  California 94303-0802 and its  telephone number is  (415)
494-5000.

                                  THE OFFERING

   
<TABLE>
<S>                                      <C>
LYONs..................................  $825,000,000 aggregate principal amount at maturity
                                          (excluding $123,750,000 aggregate principal amount
                                          at   maturity   subject   to   the   Underwriter's
                                          over-allotment option) of LYONs due July   , 2014.
                                          There will be no periodic interest payments on the
                                          LYONs. Each  LYON  will  have an  Issue  Price  of
                                          $        and a principal amount due at maturity of
                                          $1,000.
Yield to Maturity of LYONs.............  %   per  annum  (computed  on  a  semi-annual  bond
                                          equivalent basis) calculated from July   , 1994.
Conversion Rights......................  Each LYON will be convertible at the option of  the
                                         Holder  at any time on or prior to maturity, unless
                                          previously  redeemed  or  otherwise  purchased  by
                                          ALZA. Upon conversion of a LYON, ALZA may elect to
                                          deliver  shares of  Common Stock,  at a Conversion
                                          Rate of         shares per LYON, or cash equal  to
                                          the  market value  of the  shares of  Common Stock
                                          into  which   the  LYONs   are  convertible.   The
                                          Conversion  Rate will not  be adjusted for accrued
                                          Original Issue Discount,  but will  be subject  to
                                          adjustment  upon the occurrence  of certain events
                                          affecting the Common  Stock. Upon conversion,  the
                                          Holder   will   not  receive   any   cash  payment
                                          representing accrued Original Issue Discount; such
                                          accrued Original  Issue  Discount will  be  deemed
                                          paid  by the Common Stock  or cash received by the
                                          Holder on conversion. See "Description of LYONs --
                                          Conversion Rights."
Subordination..........................  The LYONs will be subordinated in right of  payment
                                         to  the prior payment  in full of  all existing and
                                          future Senior Indebtedness of ALZA, the  principal
                                          amount  of  which  as  of May  31,  1994  was $1.7
                                          million, excluding ALZA's $249.3 million principal
                                          amount of outstanding commercial paper, which will
                                          be retired with a portion of the proceeds from the
                                          sale  of  the  LYONs.  See  "Capitalization"   and
                                          "Description of LYONs -- Subordination of LYONs."
Original Issue Discount................  Each  LYON is  being offered  at an  Original Issue
                                         Discount  for  United  States  federal  income  tax
                                          purposes  equal  to  the excess  of  the principal
                                          amount at maturity  over the amount  of the  Issue
                                          Price.  Prospective purchasers of  LYONs should be
                                          aware that,  although there  will be  no  periodic
                                          payments   of  interest  on   the  LYONs,  accrued
                                          Original  Issue  Discount   will  be   includable,
                                          periodically,  in  a  Holder's  gross  income  for
                                          United States federal income tax purposes prior to
                                          conversion,  redemption,   other  disposition   or
                                          maturity   of   such   Holder's   LYONs,   whether
</TABLE>
    

                                       4
<PAGE>

   
<TABLE>
<S>                                      <C>
                                          or  not  such  LYONs  are  ultimately   converted,
                                          redeemed,  sold (to ALZA or  otherwise) or paid at
                                          maturity.  See  "Certain  United  States   Federal
                                          Income   Tax  Considerations   --  Original  Issue
                                          Discount."
Sinking Fund...........................  None.
Optional Redemption....................  The LYONs will not be  redeemable by ALZA prior  to
                                          July       ,  1999.   Thereafter,  the  LYONs  are
                                          redeemable for cash at any  time at the option  of
                                          ALZA,  in whole  or in part,  at Redemption Prices
                                          equal to  the Issue  Price plus  accrued  Original
                                          Issue  Discount  to  the date  of  redemption. See
                                          "Description of LYONs  -- Redemption  of LYONs  at
                                          the Option of ALZA."
Purchase at the Option of the Holder...  ALZA  will purchase any LYON,  at the option of the
                                          Holder, as of July  , 1999, July   , 2004 and July
                                            , 2009, for  a Purchase  Price of $            ,
                                          $          and $         (Issue Price plus accrued
                                          Original Issue  Discount to  such Purchase  Date),
                                          respectively, representing a     % yield per annum
                                          to   the  Holder  on  such  date,  computed  on  a
                                          semi-annual  bond  equivalent  basis.  Subject  to
                                          certain exceptions, ALZA, at its option, may elect
                                          to  pay the Purchase Price as of any such Purchase
                                          Date in cash or  Common Stock, or any  combination
                                          thereof.  Because the  Market Price  of any Common
                                          Stock to be delivered in  payment, in whole or  in
                                          part, of the Purchase Price is determined prior to
                                          the  applicable  Purchase Date,  Holders  of LYONs
                                          bear the market risk with respect to the value  of
                                          the Common Stock to be received from the date such
                                          Market  Price is determined to such Purchase Date.
                                          In addition,  as of  35  business days  after  the
                                          occurrence  of  any  Change  in  Control  of  ALZA
                                          occurring on or prior to July   , 1999, ALZA  will
                                          also  purchase for cash any LYON, at the option of
                                          the Holder, for a Change in Control Purchase Price
                                          equal to  the Issue  Price plus  accrued  Original
                                          Issue  Discount to the  Change in Control Purchase
                                          Date. The Change  of Control  purchase feature  of
                                          the  LYONs  may in  certain circumstances  have an
                                          anti-takeover effect. See "Description of LYONs --
                                          Purchase of LYONs at the Option of the Holder" and
                                          "-- Change in Control Permits Purchase of LYONs at
                                          the Option of the Holder."
Use of Proceeds........................  ALZA will use the net proceeds of this offering for
                                         the  retirement  at  maturity  of  all  of   ALZA's
                                          outstanding   commercial   paper,  which   had  an
                                          aggregate principal amount of $249.3 million as of
                                          May 31, 1994, and for general corporate  purposes.
                                          See "Use of Proceeds."
Listing................................  Application  has been made to list the LYONs on the
                                         New  York  Stock  Exchange.  The  Common  Stock  is
                                          currently  traded on  the New  York Stock Exchange
                                          under the symbol "AZA."
</TABLE>
    

                                       5
<PAGE>
                      SUMMARY CONSOLIDATED FINANCIAL DATA
    Set forth below are summary consolidated  financial data for ALZA as of  the
dates and for the periods indicated.

   
<TABLE>
<CAPTION>
                        THREE MONTHS ENDED MARCH 31,
                                                                                YEARS ENDED DECEMBER 31,
                       ------------------------------ -----------------------------------------------------------------------------
                           1994            1993               1993             1992           1991          1990          1989
                       ------------- ---------------- -------------------- ------------- -------------- ------------- -------------
                                (UNAUDITED)
<S>                    <C>           <C>              <C>                  <C>           <C>            <C>           <C>
                                                     (IN THOUSANDS, EXCEPT PER SHARE DATA AND RATIOS)
STATEMENT OF OPERATIONS
 DATA:
  Total revenues....... $  68,165    $  69,936(1)     $  234,182(1)        $ 250,519     $  162,349     $ 109,425     $  92,687
  Income (loss) before
   extraordinary item
   and cumulative
   effect of accounting
   change .               15,617        20,769            42,869(2)           72,170        (62,076)(3)    24,654        18,774
  Net income (loss)....    15,617       27,342(4)         45,612(4)(5)        72,170        (62,076)(3)    24,654        18,774
  Income (loss) per
   share before
   extraordinary item
   and cumulative
   effect of accounting
   change .                 0.19          0.26              0.54(2)             0.90          (0.88)(3)      0.35(6)       0.27(6)
  Net income (loss) per
   share...............      0.19         0.34(4)           0.57(4)(5)          0.90          (0.88)(3)      0.35(6)       0.27(6)
BALANCE SHEET DATA:
  Working capital...... $  76,959(7) $ 118,235        $  (87,767)(5)       $ 188,744     $  227,950     $ 335,385     $ 130,329
  Total assets.........   642,384      737,741           621,824             698,381        580,490       530,868       288,447
  Commercial paper.....   249,370           --           249,520                  --             --            --            --
  7 1/2% zero coupon
   convertible
   subordinated
   debentures (5)......        --      233,244                --             228,966        213,220       198,218            --
  5 1/2% convertible
   subordinated
   debentures..........        --           --                --                  --             --        75,000        75,000
  Other long-term
   liabilities.........    32,437       25,141            28,969              22,723         23,607        19,474        10,357
  Stockholders'
   equity..............   320,822(7)(8)   438,311        306,677(8)          407,543        322,854       219,605       186,636
OTHER DATA:
  Ratio of earnings to
   fixed charges (9)...      7.6x         6.6x              3.9x                6.3x             --(10)      6.3x          5.4x
  Pro forma ratio of
   earnings to fixed
   charges.............          (11)        --                 (11)              --             --            --            --
<FN>
- ------------------------------
 (1) Includes approximately $5.0 million ($0.04 per share on an after-tax basis)
     of  one-time investment gains realized  on long-term investments liquidated
     in connection with ALZA's contribution to TDC.
 (2) Includes pre-tax charges and allowances  of $28.1 million ($0.23 per  share
     on an after-tax basis) related primarily to manufacturing activities.
 (3) In  1991 ALZA incurred a one-time charge  of $101.3 million relating to the
     purchase of in-process  technology in  connection with  the acquisition  of
     Bio-Electro Systems, Inc., a company acquired by ALZA in early 1992.
 (4) In February 1992, the Financial Accounting Standards Board issued Statement
     of  Financial Accounting Standards  No. 109, "Accounting  for Income Taxes"
     ("SFAS 109"). ALZA  adopted the  provisions of  SFAS 109  in its  financial
     statements  for the quarter ended March  31, 1993, increasing net income by
     $6.6 million  ($0.08 per  share).  As permitted  by  SFAS 109,  prior  year
     financial  statements  have  not been  restated  to reflect  the  change in
     accounting method.
 (5) On November  15, 1993  ALZA redeemed  all of  its outstanding  7 1/2%  zero
     coupon   convertible  subordinated  debentures.  In  connection  with  this
     redemption,  ALZA  incurred   a  $3.8   million  (net   of  income   taxes)
     extraordinary  refinancing  charge.  The  7  1/2%  zero  coupon convertible
     subordinated debentures  were  replaced  with commercial  paper  which  was
     classified as short term debt, thereby reducing working capital.
 (6) Per  share data for  1989 and 1990  have been restated  to give retroactive
     effect to a two-for-one stock split effective November 1991.
 (7) In May 1993, the Financial  Accounting Standards Board issued Statement  of
     Financial Accounting Standards No. 115, "Accounting for Certain Investments
     in Debt and Equity Securities" ("SFAS 115"). ALZA adopted the provisions of
     the  new standard for investments  held as of or  acquired after January 1,
     1994. In accordance with SFAS  115, prior period financial statements  have
     not been restated to reflect the change in accounting principle. Under SFAS
     115,  all available-for-sale  securities were classified  as current assets
     and a $2.3 million  valuation allowance was established  at March 31,  1994
     for the difference between their cost and fair market value.
 (8) Stockholders'  equity decreased from December 31, 1992 to December 31, 1993
     and from  March  31, 1993  to  March 31,  1994  due primarily  to  the  TDC
     distribution in the second quarter of 1993.
 (9) The ratios of earnings to fixed charges were calculated by dividing the sum
     of  (i)  income  (loss) before  income  taxes, extraordinary  item  and the
     cumulative effect of the accounting change and (ii) fixed charges  (reduced
     by  capitalized interest costs), by fixed charges. Fixed charges consist of
     interest (expensed and capitalized), amortization of debt issue expense and
     the estimated interest portion of rent expense.
(10) Earnings for the year  ended December 31, 1991  were insufficient to  cover
     fixed charges by approximately $43 million.
(11) The  pro forma ratio of  earnings to fixed charges  assumes the 7 1/2% zero
     coupon  convertible  subordinated  debentures  and  the  commercial   paper
     outstanding   during  the  periods  presented  had  been  refinanced  on  a
     retroactive basis by the LYONs offered hereby.
</TABLE>
    

                                       6
<PAGE>
                           INVESTMENT CONSIDERATIONS

   
    DEPENDENCE  ON  RELATIONSHIPS  WITH  CLIENT COMPANIES.    ALZA's  net income
currently results primarily from  royalties and fees  paid by client  companies.
Royalties   and  fees  are  derived  from  sales  by  the  clients  of  products
incorporating ALZA technologies, and therefore vary from quarter to quarter as a
result of changing levels of product  sales by client companies. Because  ALZA's
clients make all marketing and other commercialization decisions with respect to
such  products (including,  in many  cases, taking  responsibility for obtaining
necessary regulatory  approvals),  most  of the  variables  that  affect  ALZA's
royalties  and fees are not directly  within ALZA's control. In addition, ALZA's
royalties and  fees  could be  adversely  affected  if the  pressures  for  cost
containment  in the  United States  health care system  were to  result in lower
selling prices for  royalty-bearing products.  For the year  ended December  31,
1993, Procardia XL, marketed by Pfizer, Inc., accounted for approximately 60% of
ALZA's royalties and fees.
    

   
    UNCERTAINTIES  RELATING  TO RECENT  AND PLANNED  EXPANSION OF  MARKETING AND
MANUFACTURING  ACTIVITIES.   ALZA  recently   began  marketing   the   Testoderm
transdermal  therapeutic system, and  intends to expand  its sales and marketing
activities  in   the  future,   under  co-promotion   arrangements,  under   its
arrangements  with TDC, and  under other arrangements  with third parties (which
could include the acquisition or license of products and/or technologies). While
the activities with  TDC and other  third parties  are intended to  result in  a
valuable  pipeline of products for marketing by  ALZA, there can be no assurance
that this will be the case. ALZA  also has expanded and is continuing to  expand
its  manufacturing  facilities in  anticipation  of future  manufacturing needs.
Utilization of  these  facilities  in  any  quarter  depends  on  many  factors,
including client orders, product approvals, and product launches and sales, many
of  which are outside of  ALZA's control. There can  be no assurance that ALZA's
expanded sales, marketing and manufacturing activities will be successful.
    

    VOLATILITY OF SECURITIES PRICES.  The market prices of ALZA's securities are
subject to  significant  fluctuations in  response  to variations  in  quarterly
operating  results,  announcements of  new commercial  products  by ALZA  or its
competitors, developments or disputes  concerning patent or proprietary  rights,
regulatory  developments in both the United States and foreign countries, health
care reform  and  regulation,  and  economic  and  other  external  factors.  In
addition,  the pharmaceutical  sector of  the stock  market has  in recent years
experienced significant  price  fluctuations.  Such  fluctuations,  as  well  as
economic  conditions generally, may adversely affect  the market price of ALZA's
securities.

   
    UNCERTAINTIES CONCERNING EFFECTS  OF HEALTH  CARE REFORM.   The health  care
industry  has continued  to change  rapidly as  the public,  government, medical
practitioners and the pharmaceutical  industry focus on  ways to expand  medical
coverage  while controlling  the growth in  health care costs.  Congress and the
Clinton Administration are working  on comprehensive legislative changes  which,
if   enacted,  could  put  significant  pressures  on  the  prices  charged  for
pharmaceutical products.  Similarly, prescription  drug reimbursement  practices
and  the growth  of large  managed care  organizations, as  well as  generic and
therapeutic substitution  (substitution  of a  different  product for  the  same
indication), could significantly affect ALZA's business.
    

   
    ARRANGEMENTS  POTENTIALLY INHIBITING A  CHANGE IN CONTROL  OF ALZA.  Certain
provisions of ALZA's Certificate of Incorporation and of the LYONs may inhibit a
change in control of ALZA. The provisions of ALZA's Certificate of Incorporation
granting the Board of Directors the authority to issue shares of Preferred Stock
with such terms as the Board may determine, classifying ALZA's board, preventing
stockholders from calling special meetings of ALZA's stockholders and  requiring
supermajority  votes in the event of  certain proposed business combinations may
inhibit any change in control of ALZA.  The provision in the LYONs granting  the
holders  of the LYONs the right  to require ALZA to purchase  all or any part of
the LYONs in the  event of a Change  in Control may also  inhibit any change  in
control of ALZA. See "Description of LYONs -- Change in Control Permits Purchase
of LYONs at the Option of the Holder" and "Description of Capital Stock."
    

                                       7
<PAGE>
                                USE OF PROCEEDS

   
    The aggregate net proceeds to ALZA from the sale of the LYONs offered hereby
are estimated to be approximately $    million (or approximately $    million if
the  Underwriter's over-allotment option is exercised  in full). ALZA will use a
portion of the  net proceeds  to retire at  maturity all  of ALZA's  outstanding
commercial  paper, which had an aggregate  principal amount of $249.3 million as
of May 31, 1994, and had maturities of  less than 120 days and bore interest  as
of  such date at rates  ranging from 3.97% to 4.98%  per annum. The remainder of
the net proceeds  will be  used for  general corporate  purposes, which  include
working  capital, acquisition of additional  facilities and equipment, expansion
of  ALZA's   pharmaceutical  business   (including  its   sales  and   marketing
activities),  possible expenditures under joint  ventures, partnerships or other
similar agreements,  and  the  possible  acquisition  of  assets,  technologies,
products and businesses to expand ALZA's existing operations. Pending such uses,
ALZA will invest the net proceeds of the offering in marketable securities.
    

                PRICE RANGE OF COMMON STOCK AND DIVIDEND POLICY

   
    ALZA's  Common Stock  is traded  on the  New York  Stock Exchange  under the
symbol AZA. Prior to June 1, 1992,  the Common Stock was traded on the  American
Stock  Exchange under the same  symbol. The following table  sets forth the high
and low per share sales price for the Common Stock as reported on the  composite
tape  for the applicable exchange for  the quarters indicated. The last reported
sale price for the Common Stock on the New York Stock Exchange on June 16,  1994
was  $26  1/4.  These  prices  do not  include  retail  mark-ups,  mark-downs or
commissions.
    

   
<TABLE>
<CAPTION>
                                          HIGH        LOW
                                         -------    -------
<S>                                      <C>        <C>
1992
  First Quarter......................... $55 3/4    $40 5/8
  Second Quarter........................ $48 5/8    $38 7/8
  Third Quarter......................... $50 3/8    $40 3/8
  Fourth Quarter........................ $47 3/8    $33 1/2
1993
  First Quarter......................... $47 1/8    $25 1/4
  Second Quarter........................ $35 1/8    $22 7/8
  Third Quarter......................... $26 3/4    $19 1/4
  Fourth Quarter........................ $29 1/2    $20 7/8
1994
  First Quarter......................... $30 3/4    $21
  Second Quarter (through June 16)...... $26 5/8    $20 1/4
</TABLE>
    

    ALZA has  never paid  a  cash dividend  on its  Common  Stock and  does  not
anticipate doing so in the foreseeable future.

                                       8
<PAGE>
                                 CAPITALIZATION

    The  following table  sets forth the  capitalization and  short-term debt of
ALZA and its  consolidated subsidiaries at  March 31, 1994,  and as adjusted  to
give  effect to the  sale of the  LYONs offered by  this Prospectus (assuming no
exercise of the Underwriter's over-allotment option) and assuming the retirement
at maturity of $249,370,000 aggregate principal amount of outstanding commercial
paper from the net proceeds of  the sale of the LYONs,  in each case as if  such
events had occurred on March 31, 1994.

<TABLE>
<CAPTION>
                                                                                          AS OF
                                                                                     MARCH 31, 1994
                                                                                 -----------------------
                                                                                                 AS
                                                                                   ACTUAL    ADJUSTED(1)
                                                                                 ----------  -----------
                                                                                       (UNAUDITED)
                                                                                     (IN THOUSANDS)
<S>                                                                              <C>         <C>
Short-term debt:
  Commercial paper.............................................................  $  249,370   $      --
  Other short-term debt (2)....................................................         868         868
                                                                                 ----------  -----------
    Total short-term debt......................................................  $  250,238   $     868
                                                                                 ----------  -----------
                                                                                 ----------  -----------
Long-term liabilities:
  LYONs offered hereby.........................................................  $       --   $
  Other long-term liabilities..................................................      32,437      32,437
                                                                                 ----------  -----------
    Total long-term liabilities................................................      32,437
Stockholders' equity:
  Preferred Stock, $.01 par value; 100,000 shares authorized; none issued and
   outstanding.................................................................          --          --
  Common Stock, $.01 par value, 300,000,000 shares authorized; 81,674,400
   shares issued and outstanding (3)...........................................         817         817
  Additional paid-in capital...................................................     295,818     295,818
  Unrealized losses on available-for-sale securities (unrealized loss of $3,891
   less $1,598 tax effects) (4)................................................      (2,293)     (2,293)
  Retained earnings............................................................      26,480      26,480
                                                                                 ----------  -----------
    Total stockholders' equity.................................................     320,822     320,822
                                                                                 ----------  -----------
      Total capitalization.....................................................  $  353,259   $
                                                                                 ----------  -----------
                                                                                 ----------  -----------
<FN>
- ------------------------
(1)   Adjusted to reflect: (i) the issuance of the LYONs assuming no exercise of
      the  Underwriter's  over-allotment  option  and  (ii)  the  retirement  at
      maturity of  $249,370,000 of  outstanding commercial  paper from  the  net
      proceeds  of the  sale of the  LYONs, in each  case as if  such events had
      occurred on March 31, 1994.
(2)   Other  short-term  debt  consists  entirely  of  the  current  portion  of
      long-term debt.
(3)   Excludes  5,832,501 shares reserved for  issuance pursuant to ALZA's stock
      option, stock purchase and other employee benefit plans, 1,000,000  shares
      reserved   for  issuance   upon  the  exercise   of  outstanding  warrants
      exercisable at $25  per share on  or before January  31, 1996 and  966,697
      shares  reserved for  issuance upon  the exercise  of outstanding warrants
      exercisable at $65 per share on or before December 31, 1999.
(4)   In May 1993, the Financial Accounting Standards Board issued Statement  of
      Financial   Accounting   Standards  No.   115,  "Accounting   for  Certain
      Investments in Debt and Equity Securities" ("SFAS 115"). ALZA adopted  the
      provisions  of the  new standard  for investments  held as  of or acquired
      after January 1, 1994. In accordance with SFAS 115, prior period financial
      statements have  not been  restated to  reflect the  change in  accounting
      principle.   Under  SFAS  115,   all  available-for-sale  securities  were
      classified as current assets  and a $2.3  million valuation allowance  was
      established  at March 31,  1994 for the difference  between their cost and
      fair market value.
</TABLE>

                                       9
<PAGE>
                              DESCRIPTION OF LYONS

   
    The LYONs are to be issued under an indenture to be dated as of July 1, 1994
(the "Indenture") between ALZA  and The Chase Manhattan  Bank, N.A., as  trustee
(the  "Trustee"). A copy of the form of  Indenture is filed as an exhibit to the
Registration Statement  of  which  this  Prospectus is  a  part.  The  following
summaries of certain provisions of the LYONs and the Indenture do not purport to
be complete and are subject to, and are qualified in their entirety by reference
to, all the provisions of the LYONs and the Indenture, including the definitions
therein  of certain  terms which are  not otherwise defined  in this Prospectus.
Wherever particular provisions or defined terms of the Indenture (or of the Form
of LYON which is  a part thereof)  are referred to,  such provisions or  defined
terms are incorporated herein by reference. References herein are to sections in
the Indenture and paragraphs in the Form of LYON.
    

GENERAL

   
    The  LYONs will  be unsecured  obligations of  ALZA limited  to $825,000,000
aggregate principal amount at maturity ($948,750,000 aggregate principal  amount
at maturity if the Underwriter's over-allotment option is exercised in full) and
will  mature on July   , 2014. The  principal amount at maturity of each LYON is
$1,000 and will be payable  at the office of  the Paying Agent, which  initially
will  be the Trustee, in The  City of New York, and  payment will be made at its
office in New York, or any other office of the Paying Agent maintained for  such
purpose. (Sections 2.2, 2.3 and 4.5 and Form of LYON, paragraph 3.)
    

    The  LYONs are being offered at  a substantial discount from their principal
amount at  maturity.  There  will  be no  periodic  payments  of  interest.  The
calculation  of the accrual  of Original Issue  Discount (the difference between
the Issue Price and the  principal amount at maturity of  a LYON) in the  period
during which a LYON remains outstanding will be on a semi-annual bond equivalent
basis  using a 360-day year composed of  twelve 30-day months; such accrual will
commence on the issue date of the LYONs. (Form of LYON, paragraph 1.)  Maturity,
conversion,  purchase by ALZA  at the option  of the Holder,  or redemption of a
LYON will cause Original Issue Discount and interest, if any, to cease to accrue
on such LYON, under the  terms and subject to  the conditions of the  Indenture.
(Section  2.8.) ALZA may not reissue a  LYON that has matured or been converted,
purchased by ALZA  at the  option of a  Holder, redeemed  or otherwise  canceled
(except for registration of transfer, exchange or replacement thereof). (Section
2.10.)  See "Certain United States Federal Income Tax Considerations -- Original
Issue Discount."

    The LYONs will be issued only in fully registered form, without coupons,  in
denominations  of $1,000  principal amount at  maturity or  an integral multiple
thereof. (Form of LYON, paragraph 11.) LYONs may be presented for conversion  at
the  office of the Conversion Agent and for exchange or registration of transfer
at the office of  the Registrar, each  of which initially  will be the  Trustee.
(Section  2.3.) No service charge will be  made for any registration of transfer
or exchange of LYONs;  however, ALZA may  require payment by a  Holder of a  sum
sufficient  to cover any tax, assessment or other governmental charge payable in
connection therewith. (Section 2.6.)

SUBORDINATION OF LYONS

    Indebtedness evidenced  by  the  LYONs  will be  subordinated  in  right  of
payment,  as set  forth in the  Indenture, to the  prior payment in  full of all
existing and  future  Senior  Indebtedness.  (Section 10.1  and  Form  of  LYON,
paragraph 8.) "Senior Indebtedness" means the principal of (and premium, if any)
and  unpaid interest  on all  present and  future (i)  indebtedness of  ALZA for
borrowed money, (ii) obligations of  ALZA evidenced by bonds, debentures,  notes
or  similar instruments, (iii)  indebtedness incurred, assumed  or guaranteed by
ALZA in connection with the acquisition by  it or a subsidiary of any  business,
properties  or assets (except purchase money indebtedness classified as accounts
payable under  generally accepted  accounting principles),  (iv) obligations  of
ALZA  as lessee under leases required to  be capitalized on the balance sheet of
the lessee under generally accepted accounting principles and leases of property
or assets made as part of any sale and lease-back transaction to which ALZA is a
party, (v) reimbursement  obligations of ALZA  in respect of  letters of  credit
relating   to  indebtedness  or  other  obligations  of  ALZA  that  qualify  as
indebtedness or obligations of the kind referred to in clauses (i) through  (iv)
above  and  (vi) obligations  of  ALZA under  direct  or indirect  guaranties in
respect of, and obligations (contingent  or otherwise) to purchase or  otherwise
acquire,  or  otherwise  to  assure  a  creditor  against  loss  in  respect of,
indebtedness or

                                       10
<PAGE>
obligations of others of the kinds referred to in clauses (i) through (v) above,
in each case unless, in the  instrument creating or evidencing the  indebtedness
or  obligation or pursuant to which the same is outstanding, it is provided that
such indebtedness  or obligation  is not  superior in  right of  payment to  the
LYONs. (Section 1.1.)

    By  reason of such  subordination, in the  event of dissolution, insolvency,
bankruptcy or other similar  proceedings, upon any  distribution of assets,  (i)
the  holders of Senior Indebtedness  will be entitled to  be paid in full before
payment may be made on  the LYONs and the Holders  of LYONs will be required  to
pay over their share of such distribution in respect of the LYONs to the holders
of  Senior Indebtedness until such Senior Indebtedness  is paid in full and (ii)
unsecured creditors of ALZA who  are not Holders of  LYONs or holders of  Senior
Indebtedness  may recover less, ratably, than holders of Senior Indebtedness and
may recover more, ratably, than the Holders of LYONs. (Section 10.2.)

    No payment  of  the  principal  amount at  maturity,  Issue  Price,  accrued
Original  Issue Discount, Redemption Price, Change  in Control Purchase Price or
interest, if any, with respect to any LYONs  may be made, nor may ALZA pay  cash
with  respect to the Purchase  Price or upon conversion  of any LYON (other than
cash in lieu of fractional shares) or  acquire any LYONs except as set forth  in
the  Indenture, if there shall have occurred  and be continuing (i) a default in
any payment with respect to any Senior Indebtedness of ALZA or (ii) an event  of
default  with respect to any Senior  Indebtedness of ALZA permitting the holders
thereof to accelerate the maturity thereof. (Section 10.4.)

    The LYONs will  be effectively  subordinated to  all liabilities,  including
trade   payables  and   capitalized  lease   obligations,  if   any,  of  ALZA's
subsidiaries. Any right  of ALZA to  receive assets of  any of its  subsidiaries
upon  liquidation or reorganization of the  subsidiary (and the consequent right
of the Holders of the LYONs to participate in those assets) will be  effectively
subordinated  to  the claims  of  that subsidiary's  creditors  (including trade
creditors), except to the extent that ALZA is itself recognized as a creditor of
such subsidiary, in which case the claims of ALZA would still be subordinate  to
any  security interests in the assets of such subsidiary and any indebtedness of
such subsidiary senior to that held by ALZA.

   
    As of May  31, 1994, the  principal amount of  Senior Indebtedness was  $1.7
million,  excluding  ALZA's  $249.3  million  principal  amount  of  outstanding
commercial paper, which will be retired with a portion of the proceeds from  the
sale of the LYONs. There are no restrictions in the Indenture on the creation of
additional indebtedness, including Senior Indebtedness.
    

CONVERSION RIGHTS

   
    A  Holder of a LYON may convert it  at any time before the close of business
on July   ,  2014; PROVIDED, HOWEVER, that if  a LYON is called for  redemption,
the  Holder may  convert it  at any  time before  the close  of business  on the
Redemption Date. On conversion of  a LYON, ALZA may  elect to deliver shares  of
Common  Stock or  an amount  of cash  determined as  described below.  A LYON in
respect of which a Holder has delivered a Purchase Notice or a Change in Control
Purchase Notice exercising the option of such Holder to require ALZA to purchase
such LYON may be converted only if such notice is withdrawn by a written  notice
of  withdrawal delivered to the  Paying Agent prior to  the close of business on
the Purchase Date or the Change in Control Purchase Date, as the case may be, in
accordance with the terms of the Indenture. (Form of LYON, paragraph 9.)
    

    The initial Conversion Rate  is           shares of  Common Stock per  LYON,
subject  to adjustment upon the occurrence  of certain events described below. A
Holder otherwise entitled  to a fractional  share of Common  Stock will  receive
cash  in  lieu  of such  fractional  share equal  to  the market  value  of such
fractional share based on the Sale Price on the Trading Day immediately prior to
the Conversion  Date. A  Holder may  convert  a portion  of such  Holder's  LYON
provided  that the portion is $1,000 principal amount at maturity or an integral
multiple thereof. (Sections 11.1 and 11.3 and Form of LYON, paragraph 9.)

    On conversion of a LYON,  a Holder must (i)  complete and manually sign  the
conversion  notice on  the back  of the  LYON (or  complete and  manually sign a
facsimile thereof) and deliver such notice to the Conversion Agent or any  other
office  or agency maintained  for such purpose,  (ii) surrender the  LYON to the
Conversion Agent  or such  other office  or  agency by  physical or  book  entry
delivery, (iii) if required, furnish

                                       11
<PAGE>
appropriate  endorsements and transfer  documents and (iv)  if required, pay all
transfer or similar taxes. The date  on which all of the foregoing  requirements
have  been satisfied  is the  Conversion Date. (Section  11.2 and  Form of LYON,
paragraph 9.)

    On conversion  of  a  LYON, a  Holder  will  not receive  any  cash  payment
representing  accrued Original Issue Discount. ALZA's  delivery to the Holder of
the fixed number of shares of Common Stock (or cash in the applicable amount  as
provided  below)  into which  the LYON  is convertible  (together with  the cash
payment, if any, in lieu of fractional shares) will satisfy ALZA's obligation to
pay the principal amount at maturity of the LYON including the accrued  Original
Issue  Discount attributable to the period from the Issue Date to the Conversion
Date. Thus, the accrued  Original Issue Discount  is deemed to  be paid in  full
rather  than canceled, extinguished or forfeited. (Section 11.2.) The Conversion
Rate will not  be adjusted at  any time during  the term of  the LYONs for  such
accrued Original Issue Discount.

    In  lieu of delivering shares  of Common Stock upon  notice of conversion of
any LYON, ALZA may elect to pay the Holder surrendering a LYON an amount in cash
equal to  the  Sale  Price of  a  share  of  Common Stock  on  the  Trading  Day
immediately  prior to the  Conversion Date multiplied by  the Conversion Rate in
effect on such Trading Day, subject to adjustment upon the occurrence of certain
events described below; PROVIDED, that if such payment of cash is not  permitted
pursuant  to the  provisions of  the Indenture  or otherwise,  ALZA will deliver
shares of Common  Stock (and cash  in lieu  of fractional shares)  as set  forth
below.  Upon conversion of  any LYON, ALZA  shall inform the  Holder through the
Conversion Agent of its  election to deliver  shares of Common  Stock or to  pay
cash  in  lieu  of delivery  of  such shares  no  later than  two  business days
following the Conversion Date. If ALZA elects to deliver shares of Common Stock,
such shares will  be delivered through  the Conversion Agent  no later than  the
seventh  business day following the Conversion Date. If ALZA elects to pay cash,
such cash payment will  be made to  the Holder surrendering  such LYON no  later
than  the fifth business day following  such Conversion Date. (Sections 11.1 and
11.2.) For a  discussion of  the tax  treatment of  a Holder  receiving cash  or
Common  Stock, see "Certain  United States Federal  Income Tax Considerations --
Disposition or Conversion."

    ALZA may not pay cash upon conversion  of any LYON (other than cash in  lieu
of  fractional  shares) if  there has  occurred  and is  continuing an  Event of
Default described under "Events of Default; Notice and Waiver" below (other than
a default in such payment on such LYON). (Section 11.1.)

    The "Sale Price" on any Trading Day  means the closing sale price per  share
for  the Common Stock (or,  if no closing price is  reported, the average of the
bid and ask  prices or,  if more than  one in  either case, the  average of  the
average  bid  and  the average  ask  prices) on  such  date as  reported  in the
composite transactions for  the principal United  States securities exchange  on
which  the Common Stock  is traded or,  if the Common  Stock is not  listed on a
United States  national or  regional  securities exchange,  as reported  by  the
National  Association  of  Securities  Dealers  Automated  Quotation  System.  A
"Trading Day"  means each  day on  which the  securities exchange  or  quotation
system  which  is  used to  determine  the Sale  Price  is open  for  trading or
quotation.

    The Conversion  Rate will  be  adjusted for  dividends or  distributions  on
Common   Stock  payable  in  Common  Stock  or  other  capital  stock  of  ALZA;
subdivisions,  combinations  or  certain  reclassifications  of  Common   Stock;
distributions  to all  holders of  Common Stock  of certain  rights, warrants or
options to purchase Common Stock expiring  within 60 days after the record  date
for  such distribution at a price per share less than the Sale Price at the time
specified in the Indenture; and distributions to such holders of assets or  debt
securities of ALZA or certain rights, warrants or options to purchase securities
of  ALZA (excluding cash  dividends or other cash  distributions from current or
retained earnings  other  than any  Extraordinary  Cash Dividend).  However,  no
adjustment  need be  made if  Holders may participate  in the  transactions on a
basis and with notice that the Board of Directors of ALZA determines to be  fair
and  appropriate or in certain other cases. In cases where the fair market value
of the  assets,  debt securities  or  certain  rights, warrants  or  options  to
purchase securities of ALZA distributed to stockholders exceeds the Average Sale
Price  of the Common  Stock or such  Average Sale Price  exceeds the fair market
value of  the  assets,  debt  securities  or  rights,  warrants  or  options  so
distributed,  by less than $1.00, rather than being entitled to an adjustment in
the Conversion  Rate, the  Holder of  a  LYON upon  conversion thereof  will  be

                                       12
<PAGE>
entitled  to receive, in addition  to the shares of  Common Stock into which the
LYON is convertible, the kind and  amount of assets, debt securities or  rights,
warrants  or options  comprising the  distribution that  such Holder  would have
received if such Holder had converted such LYON immediately prior to the  record
date  for determining the stockholders entitled to receive the distribution. The
Indenture permits ALZA to increase the Conversion  Rate from time to time for  a
period of time not less than 20 business days. (Sections 11.6, 11.7, 11.8, 11.9,
11.10, 11.12 and 11.14 and Form of LYON, paragraph 9.)

    If  ALZA is a party to a consolidation, merger or binding share exchange, or
transfers all or substantially all  of its assets, the  right to convert a  LYON
into  Common Stock may be changed into  a right to convert into securities, cash
or other assets of ALZA or another person. (Section 11.14.)

    In the  event of  a taxable  distribution to  holders of  Common Stock  that
results  in an adjustment of the Conversion  Rate or in the event the Conversion
Rate is increased at the  discretion of ALZA, the Holders  of the LYONs may,  in
certain  circumstances, be  deemed to  have received  a distribution  subject to
United States  federal income  tax as  a dividend.  See "Certain  United  States
Federal Income Tax Considerations -- Constructive Dividend."

REDEMPTION OF LYONS AT THE OPTION OF ALZA

   
    No  sinking fund is provided for the LYONs. The LYONs will not be redeemable
by ALZA prior to July   ,  1999. Thereafter, ALZA may redeem the LYONs for  cash
as  a whole at  any time, or  from time to time  in part, upon  not less than 30
days' nor more than 60 days' notice  of redemption given by mail to the  Holders
of LYONs. (Sections 3.1 and 3.3 and Form of LYON, paragraphs 5 and 7.)
    

   
    The  following table shows Redemption Prices of a  LYON on July   , 1999, at
each July    thereafter prior to  maturity, and at  maturity on July    ,  2014,
which prices reflect the accrued Original Issue Discount calculated to each such
date.  The Redemption Price of a LYON  redeemed between such dates would include
an additional amount reflecting the  additional Original Issue Discount  accrued
since  the next preceding  date in the  table to, but  excluding, the Redemption
Date. (Form of LYON, paragraph 5.)
    

   
<TABLE>
<CAPTION>
                                                                                    (3)
                                                                 (2)             REDEMPTION
                                            (1)           ACCRUED ORIGINAL         PRICE
REDEMPTION DATE                       LYON ISSUE PRICE  ISSUE DISCOUNT AT   %     (1)+(2)
- ------------------------------------  ----------------  ---------------------  --------------
<S>                                   <C>               <C>                    <C>
July   , 1999.......................
July   , 2000.......................
July   , 2001.......................
July   , 2002.......................
July   , 2003.......................
July   , 2004.......................
July   , 2005.......................
July   , 2006.......................
July   , 2007.......................
July   , 2008.......................
July   , 2009.......................
July   , 2010.......................
July   , 2011.......................
July   , 2012.......................
July   , 2013.......................
At maturity.........................                                            $   1,000.00
</TABLE>
    

    If less than all of  the outstanding LYONs are  to be redeemed, the  Trustee
shall select the LYONs to be redeemed in principal amounts at maturity of $1,000
or  integral multiples thereof by lot, PRO RATA or by another method the Trustee
considers fair and appropriate. If a portion of a Holder's LYONs is selected for
partial redemption  and such  Holder  converts a  portion  of such  LYONs,  such
converted  portion shall be deemed to be of the portion selected for redemption.
(Section 3.2.)

                                       13
<PAGE>
PURCHASE OF LYONS AT THE OPTION OF THE HOLDER

   
    On July     , 1999, July      , 2004 and July     , 2009 (each, a  "Purchase
Date")  ALZA will  become obligated  to purchase,  at the  option of  the Holder
thereof, any  outstanding LYON  for which  a written  Purchase Notice  has  been
delivered  by the Holder  to the Paying Agent  or to any  other office or agency
maintained for such purpose at any time from the opening of business on the date
that is 20 business days prior to such Purchase Date until the close of business
on such Purchase Date and for which such Purchase Notice has not been withdrawn,
subject to certain additional conditions. The Purchase Price payable in  respect
of a LYON shall be equal to the Issue Price plus accrued Original Issue Discount
to  the Purchase Date, with  respect to each Purchase Date,  as set forth in the
table below. ALZA,  at its  option, may  elect to  pay the  Purchase Price  with
respect  to  any  particular Purchase  Date  in  cash or  Common  Stock,  or any
combination thereof.  (Section  3.8  and  Form of  LYON,  paragraph  6.)  For  a
discussion of the tax treatment of a Holder receiving cash, Common Stock, or any
combination   thereof,   see   "Certain  United   States   Federal   Income  Tax
Considerations -- Disposition or Conversion."
    

    ALZA will be required to give notice (the "ALZA Notice") on a date not  less
than  20  business days  prior  to any  Purchase Date  to  all Holders  at their
addresses shown in the  register of the Registrar  (and to beneficial owners  if
required  by applicable law) stating, among  other things, (i) whether ALZA will
pay the Purchase  Price of LYONs  in cash  or Common Stock,  or any  combination
thereof  (and, if a combination, specifying the percentage of the Purchase Price
to be paid  in each  of cash  and Common Stock),  and (ii)  the procedures  that
Holders must follow to require ALZA to purchase LYONs from such Holder. (Section
3.8.)

    The  Purchase  Notice  given by  each  Holder  electing to  require  ALZA to
purchase LYONs  shall state  (i) the  certificate  numbers of  the LYONs  to  be
delivered by such Holder for purchase by ALZA, (ii) the portion of the principal
amount  at maturity of LYONs to be purchased, which portion must be $1,000 or an
integral multiple thereof,  (iii) that such  LYONs are to  be purchased by  ALZA
pursuant  to the applicable provisions  of the LYONs and  (iv) in the event ALZA
elects, pursuant to the ALZA Notice, to  pay the Purchase Price with respect  to
the  applicable Purchase  Date in Common  Stock (in  whole or in  part) but such
Purchase Price  is ultimately  to  be paid  in cash  because  any of  the  other
conditions  to payment of the Purchase Price in Common Stock is not satisfied by
such Purchase  Date, as  described  below, whether  such  Holder elects  (a)  to
withdraw such Purchase Notice as to some or all of the LYONs to which it relates
(stating  the principal amount at maturity  and certificate numbers of the LYONs
as to which such withdrawal shall relate)  or (b) to receive cash in respect  of
the  Purchase Price for all LYONs subject to such Purchase Notice. If the Holder
fails to indicate such Holder's choice with respect to the election described in
clause (iv) above in the  Purchase Notice, such Holder  shall be deemed to  have
elected  to receive cash in respect of  the Purchase Price for all LYONs subject
to such Purchase Notice in such circumstances. (Section 3.8.)

    Any Purchase Notice may be  withdrawn by the Holder  by a written notice  of
withdrawal  delivered  to the  Paying Agent  or  to any  other office  or agency
maintained for such purpose prior to the close of business on the Purchase Date.
The notice of withdrawal  shall state the principal  amount at maturity and  the
certificate  numbers of the LYONs as to  which the withdrawal notice relates and
the principal amount at maturity, if any, which remains subject to the  Purchase
Notice. (Section 3.10.)

    The  table below  shows the Purchase  Prices of  a LYON as  of the specified
Purchase Dates:

   
<TABLE>
<CAPTION>
                           PURCHASE DATE                              PURCHASE PRICE
                         -----------------                            --------------
<S>                                                                   <C>
July   , 1999.......................................................
July   , 2004.......................................................
July   , 2009.......................................................
</TABLE>
    

    If ALZA elects to pay the Purchase Price, in whole or in part, in shares  of
Common Stock, the number of shares of Common Stock to be delivered in respect of
the  portion of the Purchase Price to be  paid in Common Stock shall be equal to
such portion of the  Purchase Price divided  by the Market Price  of a share  of
Common  Stock. However, no  fractional shares of Common  Stock will be delivered
upon any purchase by ALZA of LYONs through the delivery of such Common Stock  in
payment, in whole or in part, of the

                                       14
<PAGE>
Purchase  Price. Instead, ALZA will  pay cash based on  the Market Price for all
fractional shares of  Common Stock.  (Section 3.8.) See  "Certain United  States
Federal Income Tax Considerations -- Disposition or Conversion."

    The  "Market Price" means the average of the Sale Prices of the Common Stock
for the five Trading  Day period ending  on the third Trading  Day prior to  the
applicable  Purchase  Date,  appropriately  adjusted to  take  into  account the
occurrence during the seven Trading Days preceding such Purchase Date of certain
events that would result in an adjustment of the Conversion Rate with respect to
the Common Stock.  Because the Market  Price of the  Common Stock is  determined
prior  to the applicable  Purchase Date, Holders  of LYONs bear  the market risk
with respect to the value of the Common Stock to be received from the date  such
Market  Price is  determined to  such Purchase  Date. ALZA  may elect  to pay in
Common Stock only if the information necessary to calculate the Market Price  is
reported  in  THE WALL  STREET JOURNAL  or another  daily newspaper  of national
circulation. (Section 3.8.)

    Upon determination of the actual number  of shares of Common Stock  issuable
in   accordance  with   the  foregoing   provisions,  ALZA   will  publish  such
determination in THE WALL STREET JOURNAL or another daily newspaper of  national
circulation. (Section 3.8.)

    ALZA's  right to purchase LYONs,  in whole or in  part, with Common Stock is
subject to ALZA satisfying various conditions, including (i) the registration of
the Common Stock under the Securities  Act and the Exchange Act, if  applicable,
and (ii) any necessary qualification or registration under applicable state laws
or the availability of an exemption from such qualification and registration and
compliance with other applicable federal securities laws. If such conditions are
not  satisfied with respect  to a Holder  or Holders by  the Purchase Date, ALZA
will pay the  Purchase Price of  the LYONs of  such Holder or  Holders in  cash.
(Section  3.8.) See "Certain United States  Federal Income Tax Considerations --
Disposition or Conversion." ALZA  may not change the  form of consideration  (or
components thereof) to be paid once ALZA has given the ALZA Notice to Holders of
LYONs,  except as described  in the second sentence  of this paragraph. (Section
3.8.)

    ALZA will comply with the provisions of Rule 13e-4, Rule 14e-1 and any other
tender offer rules under the Exchange Act which may then be applicable and  will
file Schedule 13E-4 or any other schedule required thereunder in connection with
any offer by ALZA to purchase LYONs at the option of Holders. (Section 3.13.)

    Payment  of the Purchase  Price for a  LYON for which  a Purchase Notice has
been delivered and not  validly withdrawn is conditioned  upon delivery of  such
LYON  (together with necessary endorsements) to the Paying Agent or to any other
office or agency maintained for such purpose  at any time (whether prior to,  on
or  after the  Purchase Date) after  delivery of such  Purchase Notice. (Section
3.8.) Payment of the Purchase Price for  a LYON will be made promptly  following
the  later of the Purchase  Date or the time of  delivery of such LYON. (Section
3.10.) If the Paying Agent holds, in accordance with the terms of the Indenture,
money or securities sufficient  to pay the  Purchase Price of  such LYON on  the
business  day following the Purchase Date, then, on and after the Purchase Date,
such LYON will cease to be outstanding and Original Issue Discount on such  LYON
will  cease to  accrue and  will be  deemed paid,  whether or  not such  LYON is
delivered to the Paying Agent  or to any other  office or agency maintained  for
such  purpose, and all other rights of the Holder will terminate (other than the
right to receive the Purchase Price upon delivery of the LYON). (Section 2.8.)

    ALZA's ability to purchase LYONs  with cash may be  limited by the terms  of
its  then-existing  borrowing agreements.  No LYONs  may  be purchased  for cash
pursuant to  the  provisions  described  above if  there  has  occurred  and  is
continuing  an Event of  Default described under "Events  of Default; Notice and
Waiver" below (other than a  default in the payment  of the Purchase Price  with
respect to such LYONs). (Section 3.10.)

CHANGE IN CONTROL PERMITS PURCHASE OF LYONS AT THE OPTION OF THE HOLDER

   
    In  the event of any Change in Control of ALZA occurring on or prior to July
  , 1999, each  Holder of LYONs  will have  the right, at  the Holder's  option,
subject    to    the   terms    and    conditions   of    the    Indenture,   to
    

                                       15
<PAGE>
require ALZA to become obligated to purchase all or any part (provided that  the
principal  amount at maturity must be $1,000 or an integral multiple thereof) of
the Holder's LYONs on the date that is 35 business days after the occurrence  of
such  Change in Control (the "Change in  Control Purchase Date") at a cash price
equal to the Issue Price plus accrued  Original Issue Discount to the Change  in
Control Purchase Date (the "Change in Control Purchase Price"). (Section 3.9 and
Form  of  LYON, paragraph  6.)  See "Certain  United  States Federal  Income Tax
Considerations -- Disposition or Conversion."

    Within 15 business days  after the Change in  Control, ALZA is obligated  to
give notice regarding the Change in Control to the Trustee and to all Holders of
LYONs  at  their  addresses shown  in  the  register of  the  Registrar  (and to
beneficial owners  if required  by applicable  law), which  notice shall  state,
among  other things, (i)  the date of  such Change in  Control and, briefly, the
events causing such Change in Control, (ii) the last date by which the Change in
Control Purchase Notice  must be  given, (iii)  the Change  in Control  Purchase
Date,  (iv) the  Change in Control  Purchase Price, (v)  briefly, the conversion
rights of the  LYONs, (vi)  the name  and address of  the Paying  Agent and  the
Conversion  Agent, (vii) the Conversion Rate and any adjustments thereto, (viii)
that LYONs as to which a Change in Control Purchase Notice has been given may be
converted into Common Stock  only if the Change  in Control Purchase Notice  has
been  withdrawn in  accordance with  the terms  of the  Indenture, (ix)  a brief
description of  these  rights and  the  procedures  the Holder  must  follow  to
exercise  these  rights, and  (x)  the procedures  for  withdrawing a  Change in
Control Purchase Notice. ALZA will cause a  copy of such notice to be  published
in  THE WALL STREET JOURNAL or  another daily newspaper of national circulation.
(Section 3.9.)

    To exercise this right, the Holder must deliver written notice (a "Change in
Control Purchase Notice") to the Paying Agent  or to any other office or  agency
maintained  for such purpose of the exercise of such right prior to the close of
business on the Change in Control Purchase Date. The Change in Control  Purchase
Notice  shall state (i) the certificate numbers  of the LYONs to be delivered by
the Holder  thereof for  purchase by  ALZA, (ii)  the portion  of the  principal
amount  at maturity of LYONs to be purchased, which portion must be $1,000 or an
integral multiple thereof, and (iii) that such LYONs are to be purchased by ALZA
pursuant to the applicable provisions of the LYONs. (Section 3.9.)

    Any Change in Control Purchase  Notice may be withdrawn  by the Holder by  a
written  notice of  withdrawal delivered  to the  Paying Agent  or to  any other
office or agency maintained for such purpose  prior to the close of business  on
the  Change in Control Purchase  Date. The notice of  withdrawal shall state the
principal amount at  maturity and  the certificate numbers  of the  LYONs as  to
which  the withdrawal  notice relates and  the principal amount  at maturity, if
any, that  remains subject  to a  Change in  Control Purchase  Notice.  (Section
3.10.)

    Payment  of the  Change in  Control Purchase  Price for  a LYON  for which a
Change in Control Purchase Notice has  been delivered and not validly  withdrawn
is conditioned upon delivery of such LYON (together with necessary endorsements)
to  the  Paying Agent  or  to any  other office  or  agency maintained  for such
purpose, at  any time  (whether prior  to, on  or after  the Change  in  Control
Purchase  Date) after  the delivery of  such Change in  Control Purchase Notice.
(Section 3.9.) Payment  of the Change  in Control Purchase  Price for such  LYON
will be made promptly following the later of the Change in Control Purchase Date
or the time of delivery of such LYON. (Section 3.10.) If the Paying Agent holds,
in  accordance with  the terms  of the  Indenture, money  sufficient to  pay the
Change in Control Purchase Price of such LYON on the business day following  the
Change  in Control Purchase Date, then, on  and after such date, such LYON shall
cease to be outstanding and Original Issue  Discount on such LYON will cease  to
accrue  and will be  deemed paid, whether or  not such LYON  is delivered to the
Paying Agent or to any other office  or agency maintained for such purpose,  and
all  other rights of the Holder shall terminate (other than the right to receive
the Change in Control Purchase Price upon delivery of the LYON). (Section 2.8.)

                                       16
<PAGE>
   
    Under  the  Indenture, a  "Change  in Control"  of  ALZA is  deemed  to have
occurred at such  time as (i)  there shall be  consummated any consolidation  or
merger  of ALZA in which ALZA is  not the continuing or surviving corporation or
pursuant to  which  the Voting  Stock  of ALZA  would  be converted  into  cash,
securities  or other property, in each case other than a consolidation or merger
of ALZA in which the  holders of the Voting Stock  of ALZA immediately prior  to
the consolidation or merger have, directly or indirectly, at least a majority of
the   Voting  Stock   of  the   surviving  corporation   immediately  after  the
consolidation or  merger,  or (ii)  any  person (including  its  Affiliates  and
Associates)  other than ALZA, its subsidiaries  or their employee benefit plans,
files a Schedule 13D or 14D-1 (or  any successor schedule, form or report  under
the Exchange Act) disclosing that such person has become the Beneficial Owner of
50% or more of ALZA's Voting Stock. (Section 3.9.)
    

    "Voting  Stock" means,  with respect  to any  person, capital  stock of such
person having  general voting  power under  ordinary circumstances  to elect  at
least  a majority of the board of directors, managers or trustees of such person
(irrespective of whether or not at the time capital stock of any other class  or
classes  shall have or might have voting power by reason of the happening of any
contingency). (Section 3.9.)

    ALZA will comply with the provisions of Rule 13e-4, Rule 14e-1 and any other
tender offer rules under the Exchange Act which may then be applicable and  will
file Schedule 13E-4 or any other schedule required thereunder in connection with
any  offer by ALZA to purchase  LYONs at the option of  Holders upon a Change in
Control. (Section 3.13.) The Change in Control purchase feature of the LYONs may
in certain circumstances make  more difficult or discourage  a takeover of  ALZA
and,  thus, the removal of incumbent  management. The Change in Control purchase
feature, however, is not  the result of management's  knowledge of any  specific
effort  to accumulate  shares of Common  Stock or  to obtain control  of ALZA by
means of a merger, tender offer, solicitation or otherwise, or part of a plan by
management to adopt a series of anti-takeover provisions. Instead, the Change in
Control purchase feature is a standard  term contained in other LYONs  offerings
that  have been marketed by the Underwriter and the terms of such feature result
from negotiations between ALZA and the Underwriter.

    If a Change in Control  were to occur, there can  be no assurance that  ALZA
would  have sufficient funds to pay the Change in Control Purchase Price for all
LYONs tendered by the Holders thereof.  In addition, ALZA's ability to  purchase
LYONs  with cash  may be  limited by  the terms  of its  then-existing borrowing
agreements. Payment of the Change in Control Purchase Price will be subordinated
to the repayment of Senior Indebtedness. See "Subordination of LYONs." A default
by ALZA on  its obligation to  pay the  Change in Control  Purchase Price  would
result  in an Event of Default and  could result in acceleration of the maturity
of other indebtedness of ALZA at the time outstanding pursuant to  cross-default
provisions.  See  "Events  of  Default;  Notice and  Waiver."  No  LYONs  may be
purchased if there has occurred and is continuing an Event of Default  described
under  "Events of Default; Notice and Waiver" below (other than a default in the
payment of the  Change in Control  Purchase Price with  respect to such  LYONs).
(Section 3.10.)

MERGERS AND SALES OF ASSETS BY ALZA

   
    The  Indenture provides that ALZA may not consolidate with or merge into any
other person or sell,  lease or otherwise transfer  all or substantially all  of
its  assets to any other person, unless,  among other things, (i) the resulting,
surviving or transferee person  (if other than ALZA)  is organized and  existing
under  the  laws of  the United  States, any  state thereof  or the  District of
Columbia and such  person expressly assumes  all obligations of  ALZA under  the
LYONs  and  the Indenture  and  (ii) ALZA  or  such successor  person  shall not
immediately thereafter be in default under the Indenture. Upon the assumption of
ALZA's obligations by such  a person in such  circumstances, subject to  certain
exceptions,  ALZA shall be  discharged from all obligations  under the LYONs and
the Indenture. (Section 5.1.) Certain of the foregoing transactions occurring on
or prior to July  , 1999 could result in a Change in Control of ALZA  permitting
each  Holder to require ALZA  to purchase the LYONs  of such Holder as described
above. (Section 3.9.)
    

EVENTS OF DEFAULT; NOTICE AND WAIVER

    The Indenture provides that if an  Event of Default specified therein  shall
have  occurred and be continuing, either the  Trustee or the Holders of not less
than 25% in aggregate principal amount at maturity of the LYONs then outstanding
may declare  the Issue  Price of  the  LYONs plus  the Original  Issue  Discount

                                       17
<PAGE>
on  the LYONs accrued to the date of  such declaration to be immediately due and
payable. In the case  of certain events of  bankruptcy or insolvency, the  Issue
Price  of the  LYONs plus  the Original  Issue Discount  accrued thereon  to the
occurrence of such event shall automatically  become and be immediately due  and
payable. See "Subordination of LYONs." If any LYONs are declared due and payable
before   their  stated  maturity,  the   holders  of  Senior  Indebtedness  then
outstanding shall be entitled to receive payment  in full of all amounts due  or
to  become due on or with respect to all Senior Indebtedness, or provision shall
be made for payment of such amounts, before the Holders of LYONs are entitled to
receive any  payment on  account of  the LYONs.  (Section 10.3.)  Under  certain
circumstances,  the  Holders  of a  majority  in aggregate  principal  amount at
maturity of the outstanding LYONs may rescind any such acceleration with respect
to the LYONs and its consequences.  (Section 6.2.) Interest shall accrue and  be
payable on demand upon a default in the payment of principal amount at maturity,
Issue  Price, accrued Original Issue Discount, Redemption Price, Purchase Price,
Change in  Control Purchase  Price  or cash  or shares  of  Common Stock  to  be
delivered  on conversion of  LYONs, in each  case to the  extent that payment of
such interest shall be legally enforceable. (Form of LYON, paragraph 1.)

    Under the Indenture, an Event of Default is defined as any of the following:
(i) default in payment of the principal amount at maturity, Issue Price, accrued
Original Issue Discount, Redemption Price,  Purchase Price or Change in  Control
Purchase  Price  with respect  to any  LYON  when such  becomes due  and payable
(whether or not payment is prohibited by the provisions of the Indenture),  (ii)
failure  by ALZA to deliver  shares of Common Stock or  pay cash in lieu thereof
when such Common Stock or cash is required to be delivered or paid, as the  case
may be, following conversion of a LYON, (iii) failure by ALZA to comply with any
of  its other agreements in the LYONs or  the Indenture upon the receipt by ALZA
of notice of such default by the Trustee  or by Holders of not less than 25%  in
aggregate  principal amount at maturity of the LYONs then outstanding and ALZA's
failure to  cure such  default within  60 days  after receipt  by ALZA  of  such
notice,  (iv) default  under any mortgage,  indenture or  instrument under which
there may  be  issued  or  by  which there  may  be  secured  or  evidenced  any
indebtedness  for money borrowed  of ALZA or  any Consolidated Subsidiary, which
default shall  have resulted  in such  indebtedness, in  an aggregate  principal
amount  exceeding $25,000,000, becoming or being  declared due and payable prior
to the date on which it would otherwise have become due and payable without such
indebtedness being  discharged or  such acceleration  having been  rescinded  or
annulled,  or there having been deposited in  trust a sum of money sufficient to
discharge such indebtedness within  a period of  30 days after  the giving of  a
Notice of Default by the Trustee or by Holders of not less than 25% in aggregate
principal  amount  at maturity  of the  LYONs then  outstanding, or  (v) certain
events of bankruptcy or insolvency. (Section 6.1.)

    The Trustee shall  give notice  to Holders of  the LYONs  of any  continuing
default  known  to the  Trustee  within 90  days  after the  occurrence thereof;
provided, that the  Trustee may withhold  such notice if  it determines in  good
faith  that withholding the notice is in  the interests of the Holders. (Section
7.5.)

    The Holders of a majority in  aggregate principal amount at maturity of  the
outstanding  LYONs  may direct  the  time, method  and  place of  conducting any
proceeding for any remedy  available to the Trustee  or exercising any trust  or
power  conferred on the  Trustee, provided that  such direction shall  not be in
conflict with any law or the Indenture and subject to certain other limitations.
(Section 6.5.)  Before proceeding  to  exercise any  right  or power  under  the
Indenture  at the direction  of such Holders,  the Trustee shall  be entitled to
receive from such Holders  reasonable security or  indemnity satisfactory to  it
against  any  cost,  liability or  expense  which  might be  incurred  by  it in
complying with any such direction. No Holder of any LYON will have any right  to
pursue  any remedy with respect  to the Indenture or  the LYONs, unless (i) such
Holder shall have previously  given the Trustee written  notice of a  continuing
Event of Default, (ii) the Holders of at least 25% in aggregate principal amount
at  maturity of the outstanding  LYONs shall have made  a written request to the
Trustee to pursue such remedy, (iii) such Holder or Holders have offered to  the
Trustee  reasonable security or indemnity satisfactory  to the Trustee, (iv) the
Holders of  a  majority  in  aggregate  principal  amount  at  maturity  of  the
outstanding  LYONs have not given the Trustee a direction inconsistent with such
request within 60 days after receipt of  such request and (v) the Trustee  shall
have failed to comply with the request within such 60-day period. (Section 6.6.)

                                       18
<PAGE>
    Notwithstanding  the  foregoing,  the right  of  any Holder  (i)  to receive
payment of the principal amount at maturity, Issue Price, accrued Original Issue
Discount, Redemption Price, Purchase Price  or Change in Control Purchase  Price
with respect to any LYON and any interest in respect of a default in the payment
of  any such amounts  on such LYON, on  or after the due  date expressed in such
LYON or (ii)  to institute  suit for  the enforcement  of any  such payments  or
conversion  or (iii) to convert LYONs  (including, without limitation, the right
to receive cash in lieu of Common  Stock upon conversion if ALZA has elected  to
pay  cash  with respect  thereto) shall  not be  impaired or  adversely affected
without such Holder's consent. (Section 6.7.) The Holders of at least a majority
in aggregate principal amount at maturity of the outstanding LYONs may waive  an
existing default and its consequences, other than (i) any default in any payment
on the LYONs, (ii) any default with respect to the conversion rights of LYONs or
(iii) any default in respect of certain covenants or provisions in the Indenture
which  may not  be modified without  the consent of  the Holder of  each LYON as
described in "Modification" below. (Section 6.4.)

    ALZA will be required to furnish to  the Trustee annually a statement as  to
any  default by ALZA in the performance  and observance of its obligations under
the Indenture. (Section 4.3.)

MODIFICATION

    Modification and amendment of the Indenture or the LYONs may be effected  by
ALZA and the Trustee with the consent of the Holders of not less than a majority
in aggregate principal amount at maturity of the LYONs then outstanding. Without
the  consent of each  Holder affected thereby, however,  no amendment may, among
other things, (i) reduce the principal amount at maturity, Issue Price, Purchase
Price, Change in Control Purchase Price, Redemption Price or the amount of  cash
payable  in respect of conversion upon ALZA's  election to pay cash with respect
thereto, or extend the stated maturity of  any LYON or alter the manner or  rate
of  accrual of Original Issue Discount or  interest, or make any LYON payable in
money or  securities  other  than that  stated  in  the LYON,  (ii)  reduce  the
principal amount at maturity of LYONs whose Holders must consent to an amendment
or  any  waiver  under  the Indenture,  (iii)  modify  the  Indenture provisions
relating to such  amendments or  waivers, (iv)  make any  change that  adversely
affects the right to convert any LYON or the right to require ALZA to purchase a
LYON (including, without limitation, the right to receive cash in lieu of Common
Stock upon conversion or purchase other than elimination of ALZA's option to pay
cash  in lieu of delivering shares of  Common Stock upon conversion as described
below), (v) modify the provisions of the Indenture relating to the subordination
of the LYONs in a manner that adversely affects the rights of any Holder of  the
LYONs,  or (vi) impair  the right to  institute suit for  the enforcement of any
payment with  respect  to,  or  conversion of,  the  LYONs.  (Section  9.2.)  In
addition,  no  amendment may  be  made to  the  subordination provisions  of the
Indenture that adversely affects the rights of any holder of Senior Indebtedness
then outstanding, unless the  holders of such  Senior Indebtedness (as  required
pursuant  to  the terms  of such  Senior Indebtedness)  consent to  such change.
(Section 9.2.)

    Without the consent of any Holder of  LYONs, ALZA and the Trustee may  amend
the  Indenture to  (i) cure  any ambiguity,  omission, defect  or inconsistency,
provided that such amendment does not materially adversely affect the rights  of
any  Holder, (ii) provide for  the assumption by a  successor corporation of the
obligations of ALZA under the Indenture, (iii) provide for uncertificated  LYONs
in  addition to certificated LYONs  so long as such  uncertificated LYONs are in
registered form for United  States federal income  tax purposes, (iv)  eliminate
ALZA's  option to  pay cash in  lieu of  delivering shares of  Common Stock upon
conversion of LYONs  (other than cash  in lieu of  fractional shares and  except
with  respect to  elections already  made), (v)  make any  change that  does not
adversely affect the rights of  any Holder of LYONs or  (vi) make any change  to
comply  with the Trust Indenture Act of  1939, as amended, or any requirement of
the Commission in connection with the qualification of the Indenture under  such
act. (Section 9.1.)

DISCHARGE OF THE INDENTURE

    ALZA  may  satisfy  and discharge  its  obligations under  the  Indenture by
delivering  to  the  Trustee  for  cancellation  all  outstanding  LYONs  or  by
depositing  with the Trustee, after the LYONs  have become due and payable, cash
(or, if permitted by the terms of the Indenture, other securities) sufficient to
pay at stated maturity all  of the outstanding LYONs  and paying all other  sums
payable under the Indenture by ALZA.

                                       19
<PAGE>
INFORMATION CONCERNING THE TRUSTEE

    The  Chase Manhattan Bank, N.A. is the Trustee under the Indenture. ALZA and
its subsidiaries  may  maintain  deposit  accounts  and  conduct  other  banking
transactions with the Trustee in the ordinary course of business.

CLAIMS IN BANKRUPTCY

    If  ALZA becomes the  subject of a  voluntary or involuntary  case under the
United States Bankruptcy Code, the claim of any Holder of a LYON may, under  the
Bankruptcy  Code, be limited to the Issue Price of the LYON plus that portion of
the Original Issue  Discount that is  deemed to  have accrued from  the date  of
issue  to the date of the commencement  of the bankruptcy case. In addition, the
Holders of  the  LYONs  will be  subordinated  in  right of  payment  to  Senior
Indebtedness  and effectively subordinated to indebtedness and other obligations
of ALZA's subsidiaries. See "Subordination of LYONs."

                          DESCRIPTION OF CAPITAL STOCK

   
    DESCRIPTION OF CAPITAL STOCK.   ALZA's authorized capital stock consists  of
300,000,000 shares of Common Stock, par value $.01 per share, and 100,000 shares
of  Preferred  Stock,  par value  $.01  per  share (the  "Preferred  Stock"). No
Preferred Stock is  outstanding as of  the date of  this Prospectus. For  recent
prices of Common Stock, see "Price Range of Common Stock and Dividend Policy."
    

   
    On March 31, 1994, there were 81,674,400 shares of Common Stock outstanding.
In  addition there were  1,966,697 shares of Common  Stock reserved for issuance
upon exercise  of outstanding  warrants  and 5,832,501  shares of  Common  Stock
reserved  for issuance under option  and other incentive plans.           shares
have been reserved for issuance upon conversion of the LYONs.
    

    Holders of Common Stock are entitled to one vote for each share held on  all
matters  submitted to a vote of stockholders.  Subject to any superior rights of
Preferred Stock, holders of Common  Stock are entitled to  share, on a pro  rata
basis,  in all assets  remaining after payment of  or provision for liabilities.
The shares of Common Stock are not subject to redemption. ALZA has the corporate
power to repurchase Common Stock.

    ALZA's Board  of  Directors  has  authority to  fix  or  alter  the  rights,
preferences, privileges, restrictions and other terms of any series of Preferred
Stock,  the number  of shares constituting  any such series  and the designation
thereof. ALZA has no present plans to issue any shares of Preferred Stock.

    ALZA has a classified  Board of Directors  with directors serving  staggered
terms  of three  years each.  Directors may not  be removed  by the stockholders
without cause. Special meetings  of the stockholders may  be called only by  the
Board  of Directors, the Chairman of the Board or the President. Nominations for
election of  directors  may  be  made  by the  Board  of  Directors  or  by  any
stockholder  of  record  entitled  to  vote  for  directors,  provided  that any
stockholder nominating a candidate for  director must deliver written notice  to
the Secretary of ALZA not later than the close of business 60 days in advance of
the  stockholders' meeting  or 10  days after  the date  on which  the notice of
meeting is first given  to stockholders, whichever  is later. The  stockholder's
notice  must set  forth certain information  concerning the  stockholder and the
stockholder's nominee. No  nominations for  director shall be  presented to  any
stockholders'  meeting if  not made in  compliance with  such procedures. ALZA's
bylaws also require that advance notice be given and certain other procedures be
followed with regard to any other business to be brought by a stockholder before
a meeting of  stockholders. Such procedures  include the delivery  of notice  of
such  proposal to the Secretary of ALZA not  later than the close of business 60
days in advance of the meeting or 10 days after the date on which the notice  of
meeting  is first given to stockholders, whichever is later. The notice must set
forth certain information concerning the stockholder and the proposed  business,
including  any  material  interest  of the  stockholder  in  that  business. The
provisions of  ALZA's  Certificate of  Incorporation  and bylaws  governing  the
number  and classification of the Board of Directors and certain related matters
cannot be amended without the approval of at least 75% of the Board of Directors
or the  affirmative vote  of  not less  than  80% of  the  voting power  of  the
outstanding shares of voting capital stock. The affirmative vote of at least 80%
of  the  voting power  of  the outstanding  shares  of voting  capital  stock is
required to approve certain business combinations.

                                       20
<PAGE>
    The provisions of ALZA's Certificate of Incorporation granting the Board  of
Directors  the authority to issue  Preferred Stock with such  terms as the Board
may determine, classifying  ALZA's Board, preventing  stockholders from  calling
special  meetings of ALZA's  stockholders, and requiring  supermajority votes in
the event of certain business combinations may inhibit any change in control  of
ALZA.

            CERTAIN UNITED STATES FEDERAL INCOME TAX CONSIDERATIONS

    The   following  summary  of  material  United  States  federal  income  tax
considerations is for general  information only. The summary  is based upon  the
Internal Revenue Code of 1986, as amended (the "Code"), its legislative history,
existing  and  proposed  regulations  thereunder,  published  rulings  and court
decisions, all as in effect and existing on the date hereof and all of which are
subject to change at any  time. The tax treatment of  a Holder of the LYONs  may
vary   depending  upon  the  Holder's   particular  situation.  Certain  Holders
(including insurance companies, tax-exempt organizations, individual  retirement
and other tax-deferred accounts, financial institutions, broker-dealers, foreign
corporations,  and individuals who  are not citizens or  residents of the United
States) may be subject to special  rules not discussed below. This summary  does
not  discuss the  tax considerations  of subsequent  purchasers of  LYONs and is
limited to investors who hold  LYONs as capital assets. Accordingly,  purchasers
of  LYONs  should  consult their  own  tax  advisors as  to  the  particular tax
consequences to them of acquiring, holding, converting or otherwise disposing of
the LYONs, including  the applicability and  the effect of  any state, local  or
foreign tax laws and recent changes in applicable tax laws.

    ALZA  has been advised by  Mayer, Brown & Platt,  special federal income tax
counsel to ALZA, that in the opinion  of such counsel the LYONs will be  treated
as  indebtedness for  United States federal  income tax  purposes. The following
discussion of  tax considerations  assumes that  the LYONs  will be  treated  as
indebtedness.

ORIGINAL ISSUE DISCOUNT
    The  LYONs are being  issued at a substantial  discount from their principal
amount at maturity. For federal income tax purposes, the difference between  the
issue price (the first price at which a substantial amount of the LYONs are sold
for  money)  and  the principal  amount  at  maturity of  each  LYON constitutes
Original Issue  Discount. Holders  of  the LYONs  will  be required  to  include
Original Issue Discount in income periodically over the term of the LYONs before
the  receipt of the  cash, Common Stock  or other payments  attributable to such
income.

    A Holder of  a LYON  must include  in gross  income for  federal income  tax
purposes  the sum of the daily portions  of Original Issue Discount with respect
to the LYON for each day during the taxable year or portion of a taxable year on
which such Holder holds the LYON ("Accrued Original Issue Discount"). The  daily
portion is determined by allocating to each day of the accrual period a PRO RATA
portion  of an  amount equal  to the  adjusted issue  price of  the LYON  at the
beginning of the accrual period multiplied by the yield to maturity of the  LYON
(determined  by compounding at the close of each accrual period and adjusted for
the length of the accrual  period). Under the Code,  the accrual period will  be
each  six month period which ends on the day in each calendar year corresponding
to the maturity date  of the LYON  or the date six  months before such  maturity
date.  The  information returns  provided to  holders  and the  Internal Revenue
Service (the "Service")  by the  Company regarding the  accrual of  OID will  be
based  on these six month accrual periods. Treasury regulations, however, permit
a Holder to select an accrual period of any length and to vary the length of the
accrual period over the term of the debt instrument, provided that each  accrual
period  is no longer  than one year  and each scheduled  payment of principal or
interest occurs on the final day of an accrual period or on the first day of  an
accrual period. The adjusted issue price of the LYON at the start of any accrual
period  is the issue price  of the LYON increased  by the Accrued Original Issue
Discount for each prior accrual period. Under these rules, Holders will have  to
include  in gross income increasingly greater amounts of Original Issue Discount
in each successive accrual period. ALZA will be required to furnish annually  to
the Service and to certain noncorporate Holders information regarding the amount
of Original Issue Discount attributable to that year.

DISPOSITION OR CONVERSION
    A  Holder's  basis  for  determining  gain or  loss  on  the  sale  or other
disposition of a LYON will be  increased by any Accrued Original Issue  Discount
includable in such Holder's gross income. Gain or loss

                                       21
<PAGE>
upon  a sale or other  disposition (including a sale to  ALZA or receipt of cash
from ALZA on conversion) of a LYON, except as described below, will generally be
capital gain or loss, which will be long term if the LYON has been held for more
than one year.

    A Holder's conversion of a LYON for Common Stock is generally not a  taxable
event  (except with respect to  cash received in lieu  of a fractional share). A
Holder's obligation to include  in gross income the  daily portions of  Original
Issue  Discount with respect to a LYON  will prospectively terminate on the date
of conversion. The Holder's basis in the Common Stock received on conversion  of
a  LYON will  be the  same as  the Holder's  basis in  the LYON  at the  time of
conversion (exclusive of any tax basis allocable to a fractional share).

   
    If the Holder elects to exercise the option to tender the LYONs to ALZA on a
Purchase Date  and ALZA  issues Common  Stock in  satisfaction of  the  Purchase
Price,  such exchange is  generally not a  taxable event for  federal income tax
purposes, and therefore, neither  gain nor loss would  be recognized, except  as
described  below with regard to fractional shares. In such event, a Holder's tax
basis in the  Common Stock  received in  the exchange will  be the  same as  the
Holder's  tax basis in the LYON tendered to ALZA in exchange therefor (exclusive
of any tax basis allocable to a fractional share). If the original Holder elects
to exercise his or her option to tender the LYONs to ALZA on a Purchase Date and
ALZA delivers cash and Common Stock  in satisfaction of the Purchase Price,  the
Holder  would recognize neither gain  nor loss. In such  event, the Holder's tax
basis in the  Common Stock  received in  the exchange will  be the  same as  the
Holder's  tax basis in the LYON tendered to ALZA in exchange therefor, exclusive
of any basis allocable to fractional shares as described below, decreased by the
amount of cash received in the exchange.
    

    The holding  period for  the  Common Stock  received  in the  conversion  or
exchange  will  include the  holding period  for  the LYON  tendered to  ALZA in
exchange therefor, except that the holding  period of Common Stock allocable  to
Accrued  Original Issue Discount may  commence on the day  following the date of
conversion. Gain or loss upon  a sale or other  disposition of the Common  Stock
received on conversion or exchange of a LYON will be capital gain or loss if the
Common Stock is a capital asset in the hands of the Holder.

    If  the Holder elects to  exercise his or her option  to tender the LYONs to
ALZA on a Purchase Date and ALZA  delivers cash in satisfaction of the  Purchase
Price  or if a Holder elects to exercise his or her option to tender the LYON to
ALZA for cash on a Change in Control Purchase Date, such an exchange would be  a
taxable  sale. Also, if the holder elects  to exercise the conversion option and
ALZA delivers cash equal to the value of the shares of the Common Stock, such an
exchange would be  a taxable sale.  The Holder would  recognize capital gain  or
loss  upon  the sale,  measured by  the  difference between  the amount  of cash
transferred by ALZA to the Holder and the Holder's basis in the LYON.

    Under the current advance ruling policy of the IRS, cash received in lieu of
a fractional share of Common Stock upon conversion or purchase of a LYON  should
be  treated as a payment  in exchange for the  fractional share interest in such
Common Stock. Accordingly, if the Common Stock  is a capital asset in the  hands
of the Holder, the receipt of cash in lieu of a fractional share of Common Stock
should  generally  result in  capital  gain or  loss,  if any  (measured  by the
difference between the cash received for  the fractional share and the  Holder's
tax basis in a fractional share).

CONSTRUCTIVE DIVIDEND

    If  at any time ALZA  makes a distribution of  property to stockholders that
would be taxable to  such stockholders as a  dividend for United States  federal
income  tax purposes (for example, distributions of evidences of indebtedness or
assets of ALZA,  but generally not  stock dividends or  rights to subscribe  for
Common  Stock) and,  pursuant to the  antidilution provisions of  the LYONs, the
Conversion Rate of the LYONs is increased, such increase may be deemed to be the
payment of a taxable dividend to Holders of the LYONs.

                                       22
<PAGE>
                                  UNDERWRITING

    Merrill Lynch, Pierce, Fenner &  Smith Incorporated (the "Underwriter")  has
agreed,  subject  to the  terms  and conditions  of  the Purchase  Agreement, to
purchase $825,000,000 aggregate principal amount  at maturity of the LYONs  from
ALZA.  The Underwriter  has advised  ALZA that  it proposes  to offer  the LYONs
directly to the public at the offering price set forth on the cover page of this
Prospectus. After  the  initial  public  offering, the  offering  price  may  be
changed.  The  LYONs  are  offered  subject to  receipt  and  acceptance  by the
Underwriter and  to certain  other  conditions, including  the right  to  reject
orders in whole or in part.

    ALZA  has granted the  Underwriter an option  for 30 days  after the date of
this Prospectus to purchase up to an additional $123,750,000 aggregate principal
amount at maturity  of LYONs to  cover over-allotments, if  any, at the  initial
public  offering price less the underwriting discount  as set forth on the cover
page of this Prospectus, plus accrued  Original Issue Discount, if any,  accrued
from the Issue Date, computed on a semi-annual bond equivalent basis.

    ALZA   has  agreed  to  indemnify  the  Underwriter  against  certain  civil
liabilities, including liabilities under the  Securities Act, and to  contribute
to payments the Underwriter may be required to make in respect thereof.

    ALZA  has agreed with the Underwriter not  to sell, offer to sell, grant any
option for  the sale  of, or  otherwise dispose  of or  transfer any  securities
similar  to the LYONs or any Common  Stock or any securities convertible into or
exercisable or exchangeable for such securities or Common Stock for a period  of
90  days after the date of this  Prospectus without the prior written consent of
the Underwriter other  than Common  Stock issuable  upon the  exchange of  LYONs
offered  hereby, Common Stock issued or  sold pursuant to employee benefit plans
and dividend reinvestment plans, Common Stock issued upon exercise of  currently
outstanding   options  or  warrants,  or  certain  privately  issued  restricted
securities.

    Application has been made to list the LYONs on the New York Stock Exchange.

    The Underwriter  has  previously  marketed (and  anticipates  continuing  to
market)  securities  of other  issuers under  the  trademark "LYONs."  The LYONs
offered by ALZA hereby contain certain terms and provisions which are  different
from  such other  previously marketed LYONs,  the terms and  provisions of which
also vary. See "Description of LYONs."

    From time  to  time the  Underwriter  and  certain of  its  affiliates  have
performed,  and  may  in the  future  perform, investment  banking  or financial
advisory services for ALZA.

                                 LEGAL MATTERS

   
    The validity of the issuance of the LYONs offered hereby will be passed upon
for ALZA by  Heller, Ehrman, White  & McAuliffe, Palo  Alto, California,  ALZA's
counsel.  Shearman & Sterling, San Francisco, California, will act as counsel to
the Underwriter. Mayer, Brown  & Platt, Chicago, Illinois,  will act as  special
counsel  to  the Underwriter  and as  special United  States federal  income tax
counsel to ALZA. At May 31, 1994,  Julian N. Stern, a member of Heller,  Ehrman,
White  &  McAuliffe who  is also  a director  and the  Secretary of  ALZA, owned
beneficially 158,645 shares of Common Stock (including options and warrants) and
other attorneys in that firm owned, in the aggregate, 700 shares of Common Stock
(including warrants).
    

                                    EXPERTS

    The consolidated financial statements  and financial statement schedules  of
ALZA  Corporation and  subsidiaries, appearing  or incorporated  by reference in
ALZA's Annual Report (Form 10-K) for the year ended December 31, 1993, have been
audited by Ernst &  Young, independent auditors, as  set forth in their  reports
thereon incorporated herein by reference. Such consolidated financial statements
and  financial  statement  schedules  are incorporated  herein  by  reference in
reliance upon such reports given upon the  authority of such firm as experts  in
accounting and auditing.

                                       23
<PAGE>
- -------------------------------------------
                                     -------------------------------------------
- -------------------------------------------
                                     -------------------------------------------

    NO  DEALER, SALESPERSON OR OTHER INDIVIDUAL  HAS BEEN AUTHORIZED TO GIVE ANY
INFORMATION OR  MAKE ANY  REPRESENTATIONS NOT  CONTAINED IN  THIS PROSPECTUS  IN
CONNECTION  WITH THE OFFERING COVERED BY THIS PROSPECTUS. IF GIVEN OR MADE, SUCH
INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED
BY ALZA OR  THE UNDERWRITER.  THIS PROSPECTUS DOES  NOT CONSTITUTE  AN OFFER  TO
SELL,  OR A SOLICITATION OF AN OFFER  TO BUY, ANY SECURITIES IN ANY JURISDICTION
WHERE, OR  TO  ANY  PERSON TO  WHOM,  IT  IS  UNLAWFUL TO  MAKE  SUCH  OFFER  OR
SOLICITATION.  NEITHER  THE  DELIVERY  OF  THIS  PROSPECTUS  NOR  ANY  SALE MADE
HEREUNDER SHALL, UNDER ANY CIRCUMSTANCES,  CREATE AN IMPLICATION THAT THERE  HAS
NOT  BEEN ANY CHANGE IN THE FACTS SET FORTH IN THIS PROSPECTUS OR IN THE AFFAIRS
OF ALZA SINCE THE DATE HEREOF.

                            ------------------------

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                    PAGE
                                                    -----
<S>                                              <C>
Available Information..........................           2
Incorporation of Certain Documents by
 Reference.....................................           2
Prospectus Summary.............................           3
Investment Considerations......................           7
Use of Proceeds................................           8
Price Range of Common Stock and Dividend
 Policy........................................           8
Capitalization.................................           9
Description of LYONs...........................          10
Description of Capital Stock...................          20
Certain United States Federal Income Tax
 Considerations................................          21
Underwriting...................................          23
Legal Matters..................................          23
Experts........................................          23
</TABLE>

                                  $825,000,000
                                     [LOGO]

                         LIQUID YIELD OPTION-TM- NOTES
                                    DUE 2014
                          (ZERO COUPON--SUBORDINATED)

                            ------------------------

                                   PROSPECTUS

                            ------------------------

                              MERRILL LYNCH & CO.

                                 JUNE   , 1994

                  -TM- Trademark of Merrill Lynch & Co., Inc.

- -------------------------------------------
                                     -------------------------------------------
- -------------------------------------------
                                     -------------------------------------------
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

   
ITEM 16.  EXHIBITS.
    

   
<TABLE>
<C>        <S>
     *1.1  Form of Purchase Agreement between the Registrant and the Underwriter
     *4.1  Form of Certificate for Liquid Yield Option Note (included in Exhibit 4.2)
     *4.2  Form of Indenture between the Registrant and The Chase Manhattan Bank, N.A. as
            Trustee, relating to the LYONs
     *5.1  Opinion of Heller, Ehrman, White & McAuliffe as to legality of LYONs and Common
            Stock
      8.1  Opinion of Mayer, Brown & Platt with respect to certain tax matters
    *12.1  Computation of Ratios of Earnings to Fixed Charges
     23.1  Consent of Ernst & Young, Independent Auditors
    *23.2  Consent of Heller, Ehrman, White & McAuliffe (included in its opinion filed as
            Exhibit 5.1 to this Registration Statement)
     23.3  Consent of Mayer, Brown & Platt (included in its opinion filed as Exhibit 8.1 to
            this Registration Statement)
    *24.1  Power of Attorney (included on page II-4)
    *25.1  Statement of Eligibility and Qualification under the Trust Indenture Act of 1939
            on Form T-1 of The Chase Manhattan Bank, N.A. to act as Trustee under the
            Indenture
<FN>
- ------------------------
*     Previously filed.
</TABLE>
    

                                      II-1
<PAGE>
                                   SIGNATURES

   
    Pursuant  to the requirements of the  Securities Act of 1933, the Registrant
certifies that it has  reasonable grounds to  believe that it  meets all of  the
requirements  for filing on Form S-3 and has duly caused this Amendment No. 1 to
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized, in the city of Palo Alto, State of California, on the 17th day
of June, 1994.
    

                                          ALZA CORPORATION

   
                                          __________/s/_BRUCE C. COZADD_________
                                                     Bruce C. Cozadd
                                            VICE PRESIDENT AND CHIEF FINANCIAL
                                                         OFFICER
    

   
    Pursuant to the requirements of the  Securities Act of 1933, this  Amendment
No.  1 to Registration Statement has been  signed below by the following persons
in the capacities and on the dates indicated:
    

   
<TABLE>
<CAPTION>
                      SIGNATURE                                          TITLE                         DATE
- ------------------------------------------------------  ----------------------------------------  ---------------

<C>                                                     <S>                                       <C>
                      ALEJANDRO ZAFFARONI*
     -------------------------------------------        Co-Chairman of the Board and Director       June 17, 1994
               Dr. Alejandro Zaffaroni

                           ERNEST MARIO*                Co-Chairman of the Board, Chief
     -------------------------------------------        Executive Officer and Director              June 17, 1994
                   Dr. Ernest Mario                     (Principal Executive Officer)

     -------------------------------------------        Director                                           , 1994
                   William G. Davis

                        MARTIN S. GERSTEL*
     -------------------------------------------        Director                                    June 17, 1994
                  Martin S. Gerstel

                        ROBERT J. GLASER*
     -------------------------------------------        Director                                    June 17, 1994
                 Dr. Robert J. Glaser

                         DEAN O. MORTON*
     -------------------------------------------        Director                                    June 17, 1994
                    Dean O. Morton

                      RUDOLPH A. PETERSON*
     -------------------------------------------        Director                                    June 17, 1994
                 Rudolph A. Peterson

                           JANE E. SHAW*
     -------------------------------------------        Director                                    June 17, 1994
                     Jane E. Shaw

                            ISAAC STEIN*
     -------------------------------------------        Director                                    June 17, 1994
                     Isaac Stein

                         JULIAN N. STERN*
     -------------------------------------------        Director                                    June 17, 1994
                   Julian N. Stern

                       /s/BRUCE C. COZADD               Vice President and Chief Financial
     -------------------------------------------        Officer (Principal Financial and            June 17, 1994
                   Bruce C. Cozadd                      Accounting Officer)

                *By/s/BRUCE C. COZADD
            Bruce C. Cozadd, Attorney-in-Fact
</TABLE>
    

                                      II-2
<PAGE>
                               INDEX TO EXHIBITS

   
<TABLE>
<CAPTION>
                                                                                                          SEQ. PAGE
EXHIBIT NO.                                         DESCRIPTION                                            NUMBER
- -----------  -----------------------------------------------------------------------------------------  -------------

<C>          <S>                                                                                        <C>
       *1.1  Form of Purchase Agreement between the Registrant and the Underwriter....................
       *4.1  Form of Certificate for Liquid Yield Option Note (included in Exhibit 4.2)...............
       *4.2  Form of Indenture between the Registrant and The Chase Manhattan Bank, N.A. as Trustee,
              relating to the LYONs...................................................................
       *5.1  Opinion of Heller, Ehrman, White & McAuliffe as to legality of LYONs and Common Stock....
        8.1  Opinion of Mayer, Brown & Platt with respect to certain tax matters......................
      *12.1  Computation of Ratios of Earnings to Fixed Charges.......................................
       23.1  Consent of Ernst & Young, Independent Auditors...........................................
      *23.2  Consent of Heller, Ehrman, White & McAuliffe (included in its opinion filed as Exhibit
              5.1 to this Registration Statement).....................................................
       23.3  Consent of Mayer, Brown & Platt (included in its opinion filed as Exhibit 8.1 to this
              Registration Statement).................................................................
      *24.1  Power of Attorney........................................................................
      *25.1  Statement of Eligibility and Qualification under the Trust Indenture Act of 1939 on Form
              T-1 of The Chase Manhattan Bank, N.A. to act as Trustee under the Indenture.............
<FN>
- ------------------------
*Previously filed.
</TABLE>
    

<PAGE>

                                                                     EXHIBIT 8.1


   
                                  June 17, 1994
    


ALZA Corporation
950 Page Mill Road
Palo Alto, California 94303

     Re:  REGISTRATION STATEMENT ON FORM S-3

Ladies and Gentlemen:

     We are acting as your special United States federal income tax counsel in
connection with the registration under the Securities Act of 1933, as amended,
of $948,750,000 aggregate principal amount at maturity of Liquid Yield Option -
TM- Notes due 2014 (Zero Coupon-Subordinated) (the "LYONs"-TM-) of ALZA
Corporation (the "Company"). In that capacity, we have examined the Registration
Statement on Form S-3 (the "Registration Statement") filed by the Company with
the Securities and Exchange Commission in connection with the proposed public
offering of the LYONs.

     We hereby confirm our opinion set forth in the Prospectus in the second
full paragraph under the caption "Certain United States Federal Income Tax
Considerations." Furthermore, we are of the opinion that the information in the
Registration Statement under the caption "Certain United States Federal Income
Tax Considerations," while not purporting to discuss all tax matters relating to
the LYONs, to the extent that it constitutes a summary of United States federal
income tax matters relating to the LYONs, is correct in all material respects.

     The foregoing is based on the Internal Revenue Code of 1986, as amended
(the "Code"), Treasury Regulations (including proposed Treasury Regulations)
promulgated thereunder, rulings, official pronouncements and judicial decisions,
all as in effect on the date hereof and all of which are subject to change or
different interpretations by the Internal Revenue Service or the courts.

     We consent to the use of this opinion as an exhibit to the Registration
Statement and further consent to the reference to our firm as special United
States federal income tax counsel to the Company under the caption "Legal
Matters" in the Registration statement and the Prospectus which forms a part
thereof.

                                             Very truly yours,



                                             MAYER, BROWN & PLATT

- ------------------------
- -TM-Trademark of Merrill Lynch & Co., Inc.



<PAGE>

                                                                  Exhibit 23.1


               CONSENT OF ERNST & YOUNG, INDEPENDENT AUDITORS

We consent to the reference to our firm under the caption "Experts" in
Amendment No. 1 to the Registration Statement (Form S-3, No. 33-53671) and
related Prospectus of ALZA Corporation for the registration of $825,000,000 of
zero coupon subordinated notes and to the incorporation by reference therein
of our reports dated February 24, 1994, with respect to the consolidated
financial statements of ALZA Corporation incorporated by reference in its
Annual Report (Form 10-K) for the year ended December 31, 1993 and the related
financial statements schedules included therein, filed with the Securities and
Exchange Commission.


                                              ERNST & YOUNG

Palo Alto, California
June 17, 1994



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