ALZA CORP
424B4, 1996-04-24
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                                                 Filed pursuant to
                                                 Rule 424(b)(4)
                                                 Registration Statement Numbers
                                                 333-2343 and 333-2765
 
P R O S P E C T U S
                                  $435,000,000
 
                                     [LOGO]
                5% CONVERTIBLE SUBORDINATED DEBENTURES DUE 2006
                               ------------------
 
    The 5% Convertible Subordinated Debentures due 2006 (the "Debentures") to be
issued   by  ALZA  Corporation,   a  Delaware  corporation   ("ALZA"),  will  be
convertible, at the option of the holder,  at any time on or prior to  maturity,
unless  previously redeemed or repurchased, into shares of Common Stock of ALZA,
$.01 par value per share ("Common Stock"),  at a conversion price of $38.19  per
share  of Common  Stock (equivalent  to a  conversion rate  of 26.18  shares per
$1,000  principal  amount  of  Debentures),  subject  to  certain  anti-dilution
adjustments.  See "Description  of Debentures  -- Conversion  of Debentures." On
April 23, 1996, the last reported sale price of the Common Stock as reported  on
the New York Stock Exchange was $29 3/8 per share. The Common Stock is listed on
the New York Stock Exchange under the symbol "AZA".
 
    Interest  on the Debentures will be payable on  May 1 and November 1 of each
year, commencing November 1, 1996. The Debentures will be redeemable by ALZA, in
whole or in part, at any time on or after May 1, 1999, at the redemption  prices
set  forth herein, in each case plus accrued and unpaid interest, if any, to the
redemption date; provided that the Debentures may not be redeemed by ALZA  prior
to May 1, 2000, unless the average of the Closing Prices of the Common Stock for
all  of the Trading Days during a  period of 30 consecutive calendar days ending
not more than 10 days prior to ALZA's notice to the Trustee (as defined  herein)
of  such  redemption equals  or exceeds  150%  of the  conversion price  then in
effect. In the event of a Change in Control (as defined herein), each holder  of
the  Debentures  will have  the right  to require  ALZA to  repurchase all  or a
portion of such  holder's Debentures at  100% of the  principal amount  thereof,
plus  accrued  and unpaid  interest,  if any,  to  the date  of  repurchase. See
"Description of Debentures  -- Repurchase at  Option of Holders  Upon Change  in
Control."
 
    The  Debentures are  unsecured and subordinated  in right of  payment to all
existing and  future Senior  Indebtedness (as  defined herein)  of ALZA.  As  of
December  31, 1995, ALZA had  $850,000 principal amount of  debt that would have
constituted Senior Indebtedness. The Debentures will rank pari passu with ALZA's
outstanding 5 1/4%  Liquid Yield  Option-TM- Notes due  2014 (the  "LYONs"-TM-),
which  as  of December  31,  1995 had  an  accreted value  of  $362,944,000. See
"Description of Debentures -- Subordination of Debentures."
 
    The Debentures  have  been  approved  for listing  on  the  New  York  Stock
Exchange, subject to official notice of issuance, under the symbol "AZA 06".
 
    SEE  "RISK FACTORS" BEGINNING ON PAGE 7  FOR A DISCUSSION OF CERTAIN FACTORS
WHICH SHOULD BE CAREFULLY CONSIDERED BY PROSPECTIVE PURCHASERS OF THE DEBENTURES
OFFERED HEREBY.
                             ---------------------
THESE SECURITIES HAVE NOT  BEEN APPROVED OR DISAPPROVED  BY THE SECURITIES  AND
 EXCHANGE  COMMISSION  OR  ANY  STATE  SECURITIES  COMMISSION,  NOR  HAS  THE
   SECURITIES AND  EXCHANGE COMMISSION  OR ANY  STATE SECURITIES  COMMISSION
    PASSED   UPON  THE  ACCURACY  OR   ADEQUACY  OF  THIS  PROSPECTUS.  ANY
                 REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
<TABLE>
<CAPTION>
                                                          PRICE TO          UNDERWRITING        PROCEEDS TO
                                                         PUBLIC(1)          DISCOUNT(2)           ALZA(3)
<S>                                                  <C>                 <C>                 <C>
Per Debenture......................................         100%               2.25%               97.75%
Total (4)..........................................     $435,000,000         $9,787,500         $425,212,500
</TABLE>
 
(1) Plus accrued interest, if any, from April 29, 1996.
(2) ALZA  has  agreed to  indemnify  the  Underwriter against,  and  to  provide
    contribution  with  respect to,  certain liabilities,  including liabilities
    under the Securities Act of 1933, as amended. See "Underwriting."
(3) Before deducting expenses payable by ALZA estimated at $500,000.
(4) ALZA has granted the Underwriter an option, exercisable within 30 days after
    the date of  this Prospectus, to  purchase up to  an additional  $65,250,000
    aggregate  principal amount  of Debentures  on the  same terms  as set forth
    above to cover over-allotments, if any. If the option is exercised in  full,
    the  Price to  Public, Underwriting  Discount and  Proceeds to  ALZA will be
    $500,250,000, $11,255,625 and $488,994,375, respectively. See
    "Underwriting."
                           --------------------------
 
    The Debentures are offered by the Underwriter, subject to prior sale,  when,
as  and if  issued to and  accepted by  the Underwriter, subject  to approval of
certain  legal  matters  by  counsel  for  the  Underwriter  and  certain  other
conditions. The Underwriter reserves the right to withdraw, cancel or modify any
such  offer  and to  reject orders  in whole  or  in part.  It is  expected that
delivery of the Debentures will be made in New York, New York, on or about April
29, 1996.
 
- -TM-Trademark of Merrill Lynch & Co., Inc.
 
                           --------------------------
                              MERRILL LYNCH & CO.
                                ---------------
 
                 The date of this Prospectus is April 23, 1996.
<PAGE>
    IN CONNECTION WITH THIS OFFERING,  THE UNDERWRITER MAY OVER-ALLOT OR  EFFECT
TRANSACTIONS  WHICH STABILIZE  OR MAINTAIN  THE MARKET  PRICE OF  THE DEBENTURES
OFFERED HEREBY, THE COMMON STOCK OF ALZA OR OTHER SECURITIES OF ALZA, OR ANY  OF
THEM,  AT LEVELS ABOVE THOSE  WHICH MIGHT OTHERWISE PREVAIL  IN THE OPEN MARKET.
SUCH TRANSACTIONS  MAY  BE EFFECTED  ON  THE NEW  YORK  STOCK EXCHANGE,  IN  THE
OVER-THE-COUNTER  MARKET OR  OTHERWISE. SUCH  STABILIZING, IF  COMMENCED, MAY BE
DISCONTINUED AT ANY TIME.
 
                            ------------------------
 
                             AVAILABLE INFORMATION
 
    ALZA is subject to the informational requirements of the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), and in accordance therewith  files
reports, proxy statements and other information with the Securities and Exchange
Commission   (the  "Commission").  Such  reports,  proxy  statements  and  other
information  may  be  inspected  at  the  public  reference  facilities  of  the
Commission  at Judiciary  Plaza, 450 Fifth  Street, N.W.,  Washington, DC 20549.
Copies of such material can be obtained at prescribed rates from the  Commission
at  such address. Such reports, proxy  statements and other information can also
be inspected at the Commission's regional offices at 7 World Trade Center,  13th
Floor,  New York,  New York 10019  and at  500 West Madison  Street, Suite 1400,
Chicago, Illinois 60661. In addition,  such reports, proxy statements and  other
information  concerning ALZA  may be  inspected at the  offices of  the New York
Stock Exchange at 20 Broad Street, New York, New York 10005.
 
    ALZA has filed  with the  Commission a  Registration Statement  on Form  S-3
under  the  Securities Act  of  1933, as  amended  (the "Securities  Act"), with
respect to the Debentures offered by this Prospectus. As permitted by the  rules
and  regulations of the Commission, this Prospectus  does not contain all of the
information set  forth  in  the  Registration Statement  and  the  exhibits  and
schedules  thereto.  For  further  information  with  respect  to  ALZA  and the
securities offered hereby, reference is  made to the Registration Statement  and
the  exhibits  thereto,  which may  be  examined  without charge  at  the public
reference facilities maintained by the Commission at Judiciary Plaza, 450  Fifth
Street, N.W., Washington, DC 20549, and copies of which may be obtained from the
Commission upon payment of the prescribed fees.
 
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
 
    The  following documents, which have been filed by ALZA with the Commission,
are hereby incorporated by reference in this Prospectus:
 
        (a) ALZA's Annual Report on Form 10-K for the fiscal year ended December
    31, 1995; and
 
        (b) The description of the Common Stock contained in ALZA's registration
    statement on Form 8-A filed May 14, 1992 under the Exchange Act.
 
    All documents filed by ALZA pursuant to Section 13(a), 13(c), 14 or 15(d) of
the Exchange Act  subsequent to the  date of  this Prospectus and  prior to  the
termination  of the offering of the Debentures offered hereby shall be deemed to
be incorporated by reference into this Prospectus  and to be a part hereof  from
the  respective dates of filing of such  documents. Any statement contained in a
document incorporated or deemed to be incorporated by reference herein shall  be
deemed  to be  modified or  superseded for  purposes of  this Prospectus  to the
extent that a  statement contained herein,  or in any  other subsequently  filed
document  that also  is or  is deemed  to be  incorporated by  reference herein,
modifies or  supersedes  such  statement.  Any such  statement  so  modified  or
superseded  shall  not  be  deemed,  except as  so  modified  or  superseded, to
constitute a part of this Prospectus.
 
    Upon written or oral request  directed to Corporate and Investor  Relations,
ALZA  Corporation, 950  Page Mill  Road, P.O.  Box 10950,  Palo Alto, California
94303-0802, telephone (415) 494-5222, ALZA will provide, without charge, to  any
person to whom this Prospectus is delivered, a copy of any document incorporated
by  reference in  this Prospectus (not  including exhibits to  any such document
except to  the  extent  any  such  exhibits  are  specifically  incorporated  by
reference in the information incorporated in this Prospectus).
 
                                       2
<PAGE>
                               PROSPECTUS SUMMARY
 
    STATEMENTS   MADE  IN  THIS  PROSPECTUS  RELATING  TO  PRODUCT  DEVELOPMENT,
MANUFACTURING AND MARKETING,  OR THAT  OTHERWISE RELATE TO  FUTURE PERIODS,  ARE
FORWARD-LOOKING  STATEMENTS WITHIN THE MEANING OF  SECTION 27A OF THE SECURITIES
ACT AND SECTION 21E OF THE EXCHANGE ACT. ACTUAL RESULTS COULD DIFFER  MATERIALLY
FROM  THOSE ANTICIPATED IN THE FORWARD-LOOKING STATEMENTS AS A RESULT OF CERTAIN
RISKS DESCRIBED IN THIS PROSPECTUS (INCLUDING ALZA'S ANNUAL REPORT ON FORM  10-K
FOR 1995 AND OTHER DOCUMENTS INCORPORATED HEREIN BY REFERENCE). UNLESS OTHERWISE
INDICATED  THE  INFORMATION IN  THIS PROSPECTUS  ASSUMES THAT  THE UNDERWRITER'S
OVER-ALLOTMENT OPTION IS NOT EXERCISED.
 
                                      ALZA
 
    ALZA is  a leader  in the  development and  commercialization of  innovative
pharmaceutical  products  that  incorporate  drugs  into  advanced  dosage forms
designed to provide controlled, predetermined rates of drug release for extended
time periods.  By administering  drugs  in preset  patterns and  by  alternative
routes,  ALZA's  advanced  dosage  forms, called  therapeutic  systems,  can add
medical and economic value to drug  therapies by minimizing their unpleasant  or
harmful  side  effects, optimizing  their  beneficial actions,  simplifying drug
therapy, and  increasing patient  compliance by  decreasing the  frequency  with
which medication must be administered.
 
    Historically,  most  of  ALZA's  product  development  activities  have been
undertaken pursuant to joint  development and commercialization agreements  with
pharmaceutical   companies.   These   agreements   normally   provide   for  the
pharmaceutical company client to  reimburse ALZA for  costs incurred in  product
development  and clinical evaluation of a specified product, including a portion
of general and administrative expenses. The client receives marketing rights  to
the  product and ALZA receives  royalties on the client's  sales of the product.
Generally ALZA manufactures all or a portion of the client's requirements of the
product. Among  the ALZA-developed  products commercialized  to date  by  client
companies  are Procardia XL-Registered  Trademark- (nifedipine) extended release
tablets for  the  treatment  of angina  and  hypertension,  Duragesic-Registered
Trademark-  (fentanyl) CII  for the management  of chronic pain  in patients who
require continuous opioid analgesia  for pain that cannot  be managed by  lesser
means,   Transderm-Nitro-Registered  Trademark-  (nitroglycerin),  a  once-daily
product for the prevention  of angina pectoris due  to coronary artery  disease,
and  Nicoderm-Registered Trademark- (nicotine), an  aid in smoking cessation for
relief of nicotine withdrawal symptoms.
 
    The United States health care industry has changed dramatically in the  last
several  years.  Pharmaceutical companies  have  reduced sales  forces, acquired
pharmacy benefit  companies, and  built alliances  in an  effort to  cut  costs,
secure  market share, and improve research and development productivity. In this
environment, every new pharmaceutical product must add value to the health  care
marketplace. These changes have created a unique opportunity for ALZA.
 
    Beginning  in the early 1990s and  accelerating over the past several years,
ALZA has embarked on  a three-part strategy to  capitalize on the  opportunities
created  by  the new  health  care marketplace.  First,  ALZA has  continued its
traditional product development arrangements with client companies.
 
    Second, ALZA has expanded its commercialization capabilities and  activities
through  its  ALZA  Pharmaceuticals  division.  In  1994,  ALZA  Pharmaceuticals
introduced in  the  United States  Testoderm-Registered  Trademark-(testosterone
transdermal system) CIII for hormone replacement therapy in males for conditions
associated  with a deficiency or absence of endogenous testosterone. Also during
1994, ALZA's sales force began to  co-promote in the United States two  products
developed by ALZA under agreements with client companies -- Duragesic-Registered
Trademark-   with  Janssen   Pharmaceutica,  Inc.   ("Janssen"),  and  Glucotrol
XL-Registered Trademark-  with  Pfizer  Inc. ("Pfizer").  In  April  1996,  ALZA
Pharmaceuticals  launched  in  the  United  States  Ethyol-Registered Trademark-
(amifostine), a unique agent developed  by U.S. Bioscience, Inc., indicated  for
the   reduction   of  cumulative   renal   toxicity  associated   with  repeated
administration of the chemotherapeutic drug cisplatin in patients with  advanced
ovarian cancer or advanced non-small cell lung cancer. ALZA has exclusive rights
to  market  the  product  for five  years,  with  an option  to  extend  for one
additional year; U.S. Bioscience co-promotes the  product with ALZA. As part  of
its  strategy  to  expand  its commercialization  activities,  and  in  order to
decrease ALZA's dependence on client
 
                                       3
<PAGE>
companies, ALZA  formed Therapeutic  Discovery Corporation  ("TDC") in  1993  to
develop, with ALZA, a pipeline of products for commercialization by ALZA. At the
end  of  1995, ALZA  and TDC  had more  than  20 products  in various  stages of
development, including a number in Phase III clinical evaluation.
 
    Third, in order  to extend  ALZA's leadership in  drug delivery  technology,
ALZA  formed the  ALZA Technology Institute  ("ATI") in 1994.  ATI is increasing
ALZA's investment  in  the  research and  development  of  therapeutic  systems,
including  systems for  the delivery of  biotechnology compounds and  for use in
gene therapy.
 
    ALZA's principal executive offices are located  at 950 Page Mill Road,  P.O.
Box  10950, Palo Alto,  California 94303-0802 and its  telephone number is (415)
494-5000.
 
                                  THE OFFERING
 
<TABLE>
<S>                                      <C>
The Debentures.........................  $435,000,000 aggregate principal amount
                                         ($500,250,000 aggregate  principal  amount  if  the
                                         Underwriter's  over- allotment  option is exercised
                                         in full) of 5% Convertible Subordinated  Debentures
                                         due 2006.
 
Payment of Interest....................  The Debentures will bear interest at the rate of 5%
                                         per  annum. Interest will  be payable semi-annually
                                         on May 1  and November 1  of each year,  commencing
                                         November 1, 1996. See "Description of Debentures --
                                         General."
 
Conversion Rights......................  The  Debentures are  convertible, at  the option of
                                         the holder, at  any time on  or prior to  maturity,
                                         unless  previously  redeemed  or  repurchased, into
                                         shares of Common  Stock, at a  conversion price  of
                                         $38.19  per share, subject to certain anti-dilution
                                         adjustments.  See  "Description  of  Debentures  --
                                         Conversion of Debentures."
 
Optional Redemption by ALZA............  The  Debentures  are  redeemable at  the  option of
                                         ALZA, in whole or in part, at any time on or  after
                                         May  1, 1999,  at the  redemption prices  set forth
                                         herein,  in  each  case  plus  accrued  and  unpaid
                                         interest,  if any, to the redemption date; provided
                                         that the  Debentures may  not be  redeemed by  ALZA
                                         prior  to May  1, 2000,  unless the  average of the
                                         Closing Prices of the Common  Stock for all of  the
                                         Trading  Days  during  a period  of  30 consecutive
                                         calendar days ending not more than 10 days prior to
                                         ALZA's notice  to the  Trustee of  such  redemption
                                         equals or exceeds 150% of the conversion price then
                                         in   effect.  See  "Description  of  Debentures  --
                                         Optional Redemption by ALZA."
 
Repurchase at Option of Holders Upon
 Change in Control.....................  In the  event  a  Change in  Control  occurs,  each
                                         holder of Debentures may require ALZA to repurchase
                                         all  or a  portion of  such holder's  Debentures at
                                         100% of the principal amount thereof, together with
                                         accrued interest  to  the  repurchase  date.  If  a
                                         Change  in Control were  to occur, there  can be no
                                         assurance that ALZA would have sufficient funds  to
                                         pay   the  repurchase  price   for  all  Debentures
                                         tendered by the  holders thereof. See  "Description
                                         of  Debentures --  Repurchase at  Option of Holders
                                         Upon Change in Control."
</TABLE>
 
                                       4
<PAGE>
 
<TABLE>
<S>                                      <C>
Subordination..........................  The Debentures will be subordinated to all existing
                                         and  future  Senior   Indebtedness  of  ALZA,   the
                                         principal  amount of which as  of December 31, 1995
                                         was $850,000. The Debentures  will rank pari  passu
                                         with   ALZA's  outstanding  LYONs,   which  had  an
                                         accreted value of $362,944,000 at December 31, 1995
                                         ($948,750,000  principal  amount  at  maturity   in
                                         2014).   The  Debentures  will   not  restrict  the
                                         incurrence of Senior Indebtedness  by ALZA, or  the
                                         incurrence  of other indebtedness or liabilities by
                                         ALZA or its subsidiaries. See "Capitalization"  and
                                         "Description  of  Debentures  --  General"  and "--
                                         Subordination of Debentures."
 
Use of Proceeds........................  ALZA will use the net proceeds of the offering  for
                                         general corporate purposes. See "Use of Proceeds."
 
Listing................................  The  Debentures have  been approved  for listing on
                                         the New York  Stock Exchange,  subject to  official
                                         notice  of issuance, under the symbol "AZA 06". The
                                         Common Stock is  currently traded on  the New  York
                                         Stock Exchange under the symbol "AZA".
</TABLE>
 
                                       5
<PAGE>
                      SUMMARY CONSOLIDATED FINANCIAL DATA
 
    Set  forth below  are summary  consolidated financial  data for  ALZA at the
dates and for the periods indicated.
 
<TABLE>
<CAPTION>
                                                                            YEARS ENDED DECEMBER 31,
                                                      --------------------------------------------------------------------
                                                          1995          1994          1993          1992          1991
                                                      ------------  ------------  ------------  ------------  ------------
<S>                                                   <C>           <C>           <C>           <C>           <C>
                                                                (IN THOUSANDS, EXCEPT PER SHARE DATA AND RATIOS)
STATEMENT OF OPERATIONS DATA:
  Total revenues....................................  $  350,624    $  278,756    $  234,182    $  250,519    $  162,349
  Net income (loss).................................      72,408(1)     58,120        45,612(2)     72,170       (62,076)(3)
  Net income (loss) per share.......................        0.88          0.71          0.57          0.90         (0.88  )
BALANCE SHEET DATA:
  Working capital (deficiency)......................  $  510,120    $  436,445    $  (87,767   (2) $  188,744 $  227,950
  Total assets......................................     937,215       806,252       621,824       698,381       580,490
  Commercial paper..................................          --            --       249,520  (2)         --          --
  5 1/4% zero coupon convertible subordinated
   debentures (LYONs)...............................     362,944       344,593            --            --            --
  7 1/2% zero coupon convertible subordinated
   debentures.......................................          --            --            --       228,966       213,220
  Other long-term liabilities.......................      51,770        41,192        28,969        22,723        23,607
  Total stockholders' equity........................     454,553       364,479       306,677  (4)    407,543     322,854
OTHER DATA:
  Ratio of earnings to fixed charges (5)............        5.5x          5.5x          3.9x          6.3x            --  (6)
</TABLE>
 
- --------------------------
 
 (1) Includes a pre-tax  benefit of $7  million from the  reversal of a  reserve
     established  after  a  patent  infringement suit  was  filed  by Ciba-Geigy
     Corporation against ALZA and Marion  Merrell Dow, Inc. (now Hoechst  Marion
     Roussel,  Inc.) and  a pre-tax charge  of $7  million for a  portion of the
     payment ALZA  made  to  U.S.  Bioscience,  Inc.  under  the  marketing  and
     distribution agreement for Ethyol-Registered Trademark-.
 
 (2) Includes  pre-tax charges and allowances of $28 million ($0.23 per share on
     an after-tax  basis) related  primarily to  manufacturing activities.  Also
     includes  $7 million ($0.08 per share)  in one-time benefits resulting from
     the adoption  of  Statement  of Financial  Accounting  Standards  No.  109,
     ACCOUNTING   FOR  INCOME  TAXES,  and  a   $4  million  ($0.05  per  share)
     extraordinary refinancing  charge  relating  to the  redemption  of  ALZA's
     7  1/2% zero  coupon convertible subordinated  debentures. The  7 1/2% zero
     coupon convertible subordinated  debentures were  replaced with  commercial
     paper  which was  classified as  short-term debt,  thereby reducing working
     capital.
 
 (3) In 1991 ALZA incurred a one-time pre-tax charge of $101 million ($1.38  per
     share  on  an  after-tax  basis) relating  to  the  purchase  of in-process
     technology in connection with the acquisition of Bio-Electro Systems, Inc.,
     a company acquired by ALZA in early 1992.
 
 (4) Total stockholders' equity decreased from December 31, 1992 to December 31,
     1993 primarily due to the special dividend paid in 1993 to stockholders  in
     connection with the formation of TDC, which reduced stockholders' equity by
     $250 million.
 
 (5) The ratios of earnings to fixed charges were calculated by dividing the sum
     of  (i) income (loss) before income taxes and the extraordinary refinancing
     charge and  cumulative effect  of the  accounting change  described in  (2)
     above  and (ii) fixed  charges (reduced by  capitalized interest costs), by
     fixed  charges.   Fixed  charges   consist   of  interest   (expensed   and
     capitalized), amortization of debt issue expense and the estimated interest
     portion of rent expense.
 
 (6) Earnings  for the year  ended December 31, 1991  were insufficient to cover
     fixed charges by $43 million. See (3) above.
 
                                       6
<PAGE>
                                  RISK FACTORS
 
    Statements   made  in  this  Prospectus  relating  to  product  development,
manufacturing and marketing,  or that  otherwise relate to  future periods,  are
forward-looking  statements within the meaning of  Section 27A of the Securities
Act and Section 21E of the Exchange Act. Actual results could differ  materially
from  those anticipated in the forward-looking statements as a result of certain
risks described below or elsewhere  in this Prospectus (including ALZA's  Annual
Report  on  Form  10-K  for  1995 and  other  documents  incorporated  herein by
reference).  Such  risks  should  be  considered  carefully  in  evaluating  the
Debentures and ALZA before purchasing the Debentures offered hereby.
 
    DEPENDENCE  ON  RELATIONSHIPS  WITH  CLIENT COMPANIES.    ALZA's  net income
currently results primarily from  royalties and fees  paid by client  companies.
Royalties   and  fees  are  derived  from  sales  by  the  clients  of  products
incorporating ALZA technologies, and therefore vary from quarter to quarter as a
result of changing levels of product  sales by client companies. Because  ALZA's
clients make all marketing and other commercialization decisions with respect to
such  products (including,  in many  cases, taking  responsibility for obtaining
necessary regulatory  approvals),  most  of the  variables  that  affect  ALZA's
royalties  and fees are not directly  within ALZA's control. In addition, ALZA's
royalties and fees could be adversely affected by competition and pressures  for
cost  containment. For the year ended December 31, 1995, Procardia XL-Registered
Trademark-, marketed by Pfizer, accounted for more than 40% of ALZA's  royalties
and fees.
 
    UNCERTAINTIES  RELATING  TO RECENT  AND PLANNED  EXPANSION OF  MARKETING AND
MANUFACTURING ACTIVITIES.  ALZA  has  recently  expanded  its  commercialization
activities.  ALZA  began  marketing  the  Testoderm-Registered  Trademark-  CIII
transdermal therapeutic system in 1994, and is co-promoting Duragesic-Registered
Trademark- CII with Janssen and Glucotrol XL-Registered Trademark- with  Pfizer.
ALZA  has also recently launched Ethyol-Registered Trademark- (amifostine). ALZA
intends  to  expand  its  commercialization  activities  as  a  result  of   its
arrangements  with  TDC, and  under additional  arrangements with  third parties
(which  could   include  the   acquisition  or   license  of   products   and/or
technologies).  While  the  activities  with TDC  and  other  third  parties are
intended to result  in a valuable  pipeline of products  for marketing by  ALZA,
there  can be  no assurance that  this will  be the case,  nor can  there be any
assurance generally that ALZA's commercialization activities will be successful.
ALZA also has expanded and is continuing to expand its manufacturing  facilities
in  anticipation of future manufacturing  needs. Utilization of these facilities
in any  quarter  depends  on  many factors,  including  client  orders,  product
approvals,  product  launches and  sales levels,  most of  which are  outside of
ALZA's control. There can be  no assurance that ALZA's manufacturing  activities
will be profitable.
 
    VOLATILITY OF SECURITIES PRICES.  The market prices of ALZA's securities are
subject  to  significant fluctuations  in  response to  variations  in quarterly
operating results,  announcements of  new  commercial products  by ALZA  or  its
competitors,  developments or disputes concerning  patent or proprietary rights,
regulatory developments  in both  the U.S.  and foreign  countries, health  care
reform and regulation, and economic and other external factors. In addition, the
pharmaceutical  sector  of  the stock  market  has in  recent  years experienced
significant  price  fluctuations.  Such   fluctuations,  as  well  as   economic
conditions   generally,  may  adversely  affect   the  market  price  of  ALZA's
securities, including its Common Stock and the Debentures.
 
    UNCERTAINTIES CONCERNING EFFECTS OF CHANGES IN U.S. HEALTH CARE MARKET.  The
U.S. health  care  industry has  continued  to  change rapidly  as  the  public,
government,  medical practitioners and the pharmaceutical industry focus on ways
to expand medical coverage  while controlling the growth  in health care  costs.
Legislative  changes continue to  be proposed, many of  which, if enacted, could
put significant pressures  on the  prices charged  for pharmaceutical  products.
Similarly,  prescription drug  reimbursement practices  and the  growth of large
managed care  organizations, as  well as  generic and  therapeutic  substitution
(substitution   of  a  different   product  for  the   same  indication),  could
significantly affect ALZA's business.
 
    ARRANGEMENTS POTENTIALLY INHIBITING A  CHANGE IN CONTROL  OF ALZA.   Certain
provisions  of ALZA's Certificate of Incorporation, the LYONs and the Debentures
may inhibit a change in control of ALZA. The provisions of ALZA's Certificate of
Incorporation granting the Board of Directors  the authority to issue shares  of
Preferred  Stock  with  such terms  as  the  Board of  Directors  may determine,
classifying ALZA's  Board of  Directors,  preventing stockholders  from  calling
special meetings of ALZA's stockholders and requiring supermajority votes in the
event   of  certain  proposed  business  combinations  may  inhibit  any  change
 
                                       7
<PAGE>
in control of ALZA. Provisions in the Debentures and the outstanding LYONs grant
the holders of these securities the right  to require ALZA to repurchase all  or
any  part of the Debentures and  the LYONs in the event  of a change in control,
which may  also inhibit  any change  in  control of  ALZA. See  "Description  of
Debentures  --  Repurchase at  Option  of Holders  Upon  Change in  Control" and
"Description of Capital Stock."
 
    SUBORDINATION.  The Debentures will  be unsecured and subordinated in  right
of  payment in full to all existing and future Senior Indebtedness of ALZA. As a
result of such  subordination, in the  event of any  insolvency, liquidation  or
reorganization of ALZA or upon acceleration of the Debentures due to an Event of
Default,  the  assets  of ALZA  will  be  available to  pay  obligations  on the
Debentures and any other subordinated indebtedness of ALZA only after all Senior
Indebtedness has  been paid  in full,  and there  may not  be sufficient  assets
remaining  to pay  amounts due  on any or  all of  the Debentures  and any other
subordinated indebtedness  of  ALZA then  outstanding.  The Indenture  does  not
prohibit  or limit  the incurrence of  Senior Indebtedness or  the incurrence of
other indebtedness and other  liabilities by ALZA or  its subsidiaries, and  the
incurrence  of  additional indebtedness  and other  liabilities  by ALZA  or its
subsidiaries could adversely affect ALZA's ability to pay its obligations on the
Debentures. ALZA anticipates  that from time  to time it  will incur  additional
indebtedness,  including Senior Indebtedness. See  "Description of Debentures --
Subordination of Debentures."
 
    ABSENCE OF ESTABLISHED MARKET FOR DEBENTURES.  Prior to the offering of  the
Debentures,  there has  been no public  market for the  Debentures. Although the
Debentures have  been  approved for  listing  on  the New  York  Stock  Exchange
(subject  to official  notice of  issuance), there can  be no  assurance that an
active public market  will develop for  the Debentures or  that, if such  market
develops,  the market price will  equal or exceed the  public offering price set
forth on the cover page of this Prospectus. The initial public offering price of
the  Debentures  will  be  determined  by  negotiation  between  ALZA  and   the
Underwriter  and may  not be  indicative of the  market price  of the Debentures
after the offering of the Debentures hereby.
 
                                       8
<PAGE>
                                USE OF PROCEEDS
 
    The aggregate net proceeds to ALZA  from the sale of the Debentures  offered
hereby are estimated to be approximately $424.7 million (or approximately $488.5
million  if the Underwriter's over-allotment option  is exercised in full). ALZA
will use the  net proceeds  for general  corporate purposes,  which may  include
expansion  of ALZA's pharmaceutical business  (including its sales and marketing
activities),  expansion  of  its  research  and  development  and  manufacturing
facilities,  expenditures under existing or  future joint ventures, partnerships
or other similar agreements, the  completion or continuation of the  development
of   TDC  products,  the  acquisition  of  assets,  technologies,  products  and
businesses to expand ALZA's operations, and working capital. Pending such  uses,
ALZA will invest the net proceeds of the offering in marketable securities.
 
                PRICE RANGE OF COMMON STOCK AND DIVIDEND POLICY
 
    ALZA's  Common Stock  is traded  on the  New York  Stock Exchange  under the
symbol "AZA". The following table  sets forth the high  and low per share  sales
price  for the Common Stock  as reported on the  composite tape for the quarters
indicated. The last reported  sale price for  the Common Stock  on the New  York
Stock Exchange on April 23, 1996 was $29 3/8. These prices do not include retail
mark-ups, mark-downs or commissions.
 
<TABLE>
<CAPTION>
                                              HIGH         LOW
                                             -------     -------
<S>                                          <C>         <C>
1994
  First Quarter.........................     $   30 3/4  $   21
  Second Quarter........................         26 5/8      20 1/4
  Third Quarter.........................         24 1/8      20 1/8
  Fourth Quarter........................         20 3/4      17
1995
  First Quarter.........................         24 1/8      18 1/8
  Second Quarter........................         24 5/8      18 3/8
  Third Quarter.........................         27          22 1/8
  Fourth Quarter........................         25 1/8      20 1/4
1996
  First Quarter.........................         34 7/8      24 3/8
  Second Quarter (through April 23).....         32 1/2      29 1/8
</TABLE>
 
    ALZA  has  never paid  a  cash dividend  on its  Common  Stock and  does not
anticipate doing so in the foreseeable future.
 
                                       9
<PAGE>
                                 CAPITALIZATION
 
    The following table  sets forth  the capitalization and  short-term debt  of
ALZA  and its consolidated subsidiaries at December 31, 1995, and as adjusted to
give effect to the sale of  the Debentures offered by this Prospectus  (assuming
no exercise of the Underwriter's over-allotment option).
 
<TABLE>
<CAPTION>
                                                        DECEMBER 31, 1995
                                                    --------------------------
(IN THOUSANDS, EXCEPT SHARE AND PER SHARE AMOUNTS)    ACTUAL
                                                    ----------
                                                                AS ADJUSTED(1)
                                                                --------------
                                                                 (UNAUDITED)
 
Short-term debt (2)...............................    $    869      $      869
<S>                                                 <C>         <C>
                                                    ----------  --------------
                                                    ----------  --------------
Long-term liabilities:
  5 1/4% zero coupon convertible subordinated
   debentures (LYONs).............................    $362,944      $  362,944
  5% convertible subordinated debentures offered
   hereby.........................................          --         435,000
  Other long-term liabilities.....................      51,770          51,770
                                                    ----------  --------------
      Total long-term liabilities.................     414,714         849,714
                                                    ----------  --------------
Stockholders' equity:
  Common Stock, $.01 par value, 300,000,000 shares
   authorized; 82,506,419 shares issued and
   outstanding (3)................................         825             825
  Additional paid-in capital......................     310,451         310,451
  Unrealized gains on available-for-sale
   securities (net of $1,313 tax effect)..........       1,886           1,886
  Retained earnings...............................     141,391         141,391
                                                    ----------  --------------
    Total stockholders' equity....................     454,553         454,553
                                                    ----------  --------------
      Total capitalization........................    $869,267      $1,304,267
                                                    ----------  --------------
                                                    ----------  --------------
</TABLE>
 
- ------------------------
(1) Adjusted  to reflect the issuance of the Debentures, assuming no exercise of
    the Underwriter's over-allotment option.
 
(2) Short-term debt consists entirely of the current portion of long-term debt.
 
(3) Excludes 4,863,868 shares  reserved for  issuance pursuant  to ALZA's  stock
    option  and stock  purchase plans,  12,321,416 shares  reserved for issuance
    upon conversion of the LYONs, 966,803 shares reserved for issuance upon  the
    exercise  of outstanding warrants exercisable at  $65 per share on or before
    December 31, 1999 issued in connection with the formation of TDC,  1,000,000
    shares   reserved  for  issuance  upon   exercise  of  outstanding  warrants
    exercisable at $25 per share on  or before January 31, 1996 (which  warrants
    were  exercised  subsequent  to  December 31,  1995)  and  11,390,416 shares
    reserved for  issuance  upon  conversion  of  the  Debentures  (assuming  no
    exercise of the Underwriter's over-allotment option).
 
                                       10
<PAGE>
                           DESCRIPTION OF DEBENTURES
 
    The Debentures will be issued under an Indenture, dated as of April 23, 1996
(the  "Indenture"), between ALZA and The  Chase Manhattan Bank, N.A., as trustee
(the "Trustee"). A copy of the form of  the Indenture is filed as an exhibit  to
the  Registration Statement  of which this  Prospectus is a  part. The following
summaries of  certain provisions  of the  Debentures and  the Indenture  do  not
purport  to be complete and are subject  to, and are qualified in their entirety
by reference to,  all of  the provisions of  the Debentures  and the  Indenture,
including   the  definitions  therein  of  certain  terms.  Wherever  particular
provisions or defined terms of the Indenture (or the form of Debenture which  is
a  part  thereof)  are  referred  to,  such  provisions  or  defined  terms  are
incorporated herein by  reference. As  used in the  "Description of  Debentures"
references  to  "ALZA"  refer  to  ALZA  Corporation  and  not  to  any  of  its
subsidiaries.
 
GENERAL
 
    The  Debentures  will  represent  unsecured  general  obligations  of   ALZA
subordinate  in  right  of  payment  to certain  other  obligations  of  ALZA as
described under "--  Subordination of  Debentures" and  convertible into  Common
Stock  as described under "-- Conversion  of Debentures." The Debentures will be
limited  to  $435,000,000  aggregate  principal  amount  ($500,250,000  if   the
over-allotment   option  is  exercised   in  full),  will   be  issued  only  in
denominations of $1,000 or any integral multiple thereof and will mature on  May
1, 2006, unless earlier redeemed at the option of ALZA or repurchased by ALZA at
the  option of the holder upon a Change in Control (as defined in the Indenture)
or converted.
 
    The Debentures will bear interest at the annual rate set forth on the  cover
page  hereof from April 29, 1996, payable  semi-annually on May 1 and November 1
of each year, commencing November 1, 1996, to holders of record at the close  of
business on the preceding April 15 and October 15, respectively (other than with
respect  to a Debenture or portion thereof called for redemption on a redemption
date, or repurchased in connection with a Change in Control on a Repurchase Date
(as defined below) during the period from the record date to (but excluding) the
next succeeding interest payment date (in  which case accrued interest shall  be
payable to the extent required to the holder of the Debenture or portion thereof
redeemed or repurchased), or converted after the record date and before the next
succeeding  interest payment  date except  to the extent  that at  the time such
Debenture or  portion thereof  is submitted  for conversion,  such Debenture  or
portion  thereof was required to  be accompanied by funds  equal to the interest
payable on such  succeeding interest  payment date  on the  principal amount  so
converted;  see "-- Conversion  of Debentures" below). Interest  will be paid by
check mailed  to such  holders. Interest  will be  computed on  the basis  of  a
360-day year composed of twelve 30-day months.
 
    Principal  and premium, if any,  will be payable, and  the Debentures may be
presented for conversion, registration of transfer and exchange, without service
charge, at the office of ALZA or  its agent maintained for such purposes in  The
City  of New York, which shall initially be  an office or agency of the Trustee.
The Debentures will be convertible at the aforesaid offices of ALZA or its agent
maintained for such purpose.
 
    The Debentures will be issued only in fully registered form without coupons,
in denominations of $1,000 and any integral multiple thereof. The Debentures are
exchangeable and transfers thereof will  be registered without charge  therefor,
but  ALZA may  require payment  of a sum  sufficient to  cover any  tax or other
governmental charge payable in connection therewith.
 
    When issued,  the Debentures  will be  a  new issue  of securities  with  no
established  trading  market. Although  the  Debentures have  been  approved for
listing on the New York Stock Exchange (subject to official notice of issuance),
there can be  no assurance that  an active  public market will  develop for  the
Debentures  or that,  if such  market develops, the  market price  will equal or
exceed the public offering price set forth on the cover page of this Prospectus.
The initial  public offering  price  of the  Debentures  will be  determined  by
negotiation  between ALZA and the  Underwriter and may not  be indicative of the
market price of the Debentures after the offering of the Debentures hereby.
 
    The Indenture does not  contain any financial  covenants or restrictions  on
the  payment of dividends, the incurrence of Senior Indebtedness or the issuance
or repurchase of securities of ALZA. The Indenture
 
                                       11
<PAGE>
contains no covenants  or other provisions  to afford protection  to holders  of
Debentures in the event of a highly leveraged transaction or a change in control
of ALZA except to the extent described under
"-- Repurchase at Option of Holders Upon Change in Control."
 
CONVERSION OF DEBENTURES
 
    The  holders of Debentures will be entitled,  at any time prior to the close
of business  on the  final maturity  date of  the Debentures,  subject to  prior
redemption  or repurchase,  to convert  any Debentures  or portions  thereof (in
denominations of $1,000 or multiples thereof) into Common Stock of ALZA, at  the
conversion  price set forth on  the cover page hereof,  subject to adjustment as
described below.  Except as  described  below, no  adjustment  will be  made  on
conversion  of any Debentures  for interest accrued thereon  or for dividends on
any Common  Stock  issued. If  any  Debentures  not called  for  redemption  are
converted  after a record date for the payment of interest and prior to the next
succeeding interest payment date, such  Debentures must be accompanied by  funds
equal  to the interest payable  on such succeeding interest  payment date on the
principal amount so converted. ALZA is  not required to issue fractional  shares
of  Common Stock upon conversion of Debentures  and, in lieu thereof, will pay a
cash adjustment based upon the market price of Common Stock on the last  Trading
Day  (as defined in the Indenture) prior to  the date of conversion. In the case
of Debentures called for redemption, conversion rights will expire at the  close
of  business on the business day preceding  the date fixed for redemption unless
ALZA defaults in  payment of  the redemption price.  A Debenture  in respect  of
which  a holder is exercising its option  to require repurchase upon a Change in
Control may be converted only if such holder withdraws its election to  exercise
its repurchase option in accordance with the terms of the Indenture.
 
    The  initial conversion price  is subject to  adjustment (under formulae set
forth in the Indenture) in certain events, including: (i) the issuance of Common
Stock as  a dividend  or distribution  on  Common Stock  of ALZA;  (ii)  certain
subdivisions  and combinations  of the Common  Stock; (iii) the  issuance to all
holders of Common Stock of certain rights or warrants to purchase Common  Stock;
(iv)  the distribution to all holders of Common Stock of shares of capital stock
of ALZA (other than Common Stock) or evidences of indebtedness of ALZA or assets
(including securities,  but  excluding  those rights,  warrants,  dividends  and
distributions  referred to above or paid  in cash); (v) distributions consisting
of cash, excluding any cash dividends or other distributions on the Common Stock
made in any  12-month period  which, when combined  with (A)  all such  all-cash
distributions made within such 12-month period in respect of which no adjustment
has been made plus (B) any cash and the fair market value of other consideration
payable  in respect of any tender offers by  ALZA or any of its subsidiaries for
Common Stock  concluded within  such  12-month period  in  respect of  which  no
adjustment  has been  made, do  not exceed  15% of  ALZA's market capitalization
(being the product of the Current Market Price (as defined in the Indenture)  of
the Common Stock times the number of shares of Common Stock then outstanding) on
the record date for such dividend or distribution, and excluding any dividend or
distribution  in connection with  the liquidation, dissolution  or winding up of
ALZA; and (vi) payment in respect of a  tender or exchange offer by ALZA or  any
subsidiary of ALZA for the Common Stock to the extent that the cash and value of
any  other  consideration included  in such  payment per  share of  Common Stock
exceeds the Current  Market Price  (as defined in  the Indenture)  per share  of
Common  Stock on the Trading Day next  succeeding the last date on which tenders
or exchanges may be made pursuant to such tender or exchange offer.
 
    No adjustment will be made with respect to clause (iii) or (iv) above if the
Debenture holders are to participate in such issuance or distribution on a basis
and with  notice  that ALZA's  Board  of Directors  determines  to be  fair  and
appropriate  in light of the basis on which holders of Common Stock participate.
In addition, no adjustment will be made with respect to clause (iv) above if, in
lieu of  such  adjustment,  the  Debenture holders,  upon  conversion,  will  be
entitled  to receive, in addition to the  shares of Common Stock into which such
Debentures are  convertible,  the  kind  and  amount  of  shares,  evidences  of
indebtedness  or assets comprising the distribution that such holders would have
received had they  converted their  Debentures immediately prior  to the  record
date for determining the stockholders entitled to receive such distribution.
 
                                       12
<PAGE>
    In  addition, the Indenture  provides that if  ALZA implements a stockholder
rights plan,  such  rights  plan  must  provide  that  upon  conversion  of  the
Debentures  the holders will  receive, in addition to  the Common Stock issuable
upon such conversion,  the rights  issued under such  plan (notwithstanding  the
occurrence  of an event causing such rights to separate from the Common Stock at
or prior to the time of conversion).
 
    In the case of  (i) any reclassification  or change of  the Common Stock  or
(ii)  a  consolidation,  merger  or  combination involving  ALZA  or  a  sale or
conveyance to another person of the property  and assets of ALZA as an  entirety
or  substantially as an entirety,  in each case as a  result of which holders of
Common Stock  shall  be  entitled  to receive  stock,  other  securities,  other
property  or assets  (including cash)  with respect to  or in  exchange for such
Common Stock, the holders  of the Debentures then  outstanding will be  entitled
thereafter  to convert  such Debentures  into the kind  and amount  of shares of
stock, other securities or other property or assets which they would have  owned
or  been entitled to receive  upon such reclassification, change, consolidation,
merger, combination, sale or conveyance had such Debentures been converted  into
Common  Stock immediately prior to such reclassification, change, consolidation,
merger, combination, sale  or conveyance  assuming that a  holder of  Debentures
would  not  have  exercised  any  rights of  election  as  to  the  stock, other
securities or other property or assets receivable in connection therewith.
 
    In the event of a taxable distribution to holders of Common Stock (or  other
transaction)  which  results  in any  adjustment  of the  conversion  price, the
holders of Debentures may, in certain circumstances, be deemed to have  received
a  distribution subject to  United States income  tax as a  dividend; in certain
other circumstances, the absence of such  an adjustment may result in a  taxable
dividend  to  the  holders of  Common  Stock.  See "Certain  Federal  Income Tax
Considerations."
 
    ALZA from  time to  time  may to  the extent  permitted  by law  reduce  the
conversion  price by any amount for any period  of at least 20 business days, in
which case ALZA shall give at least 15 days' notice of such reduction. ALZA may,
at its option,  make such  reductions in the  conversion price,  in addition  to
those  set forth above,  as the Board  of Directors deems  advisable to avoid or
diminish any income tax to holders  of Common Stock resulting from any  dividend
or  distribution of stock (or rights to acquire stock) or from any event treated
as  such   for  income   tax   purposes.  See   "Certain  Federal   Income   Tax
Considerations."
 
    No  adjustment  in  the  conversion  price  will  be  required  unless  such
adjustment would require a change of at least 1% in the conversion price then in
effect; provided that any adjustment that would otherwise be required to be made
shall be carried forward  and taken into account  in any subsequent  adjustment.
Except  as  stated above,  the conversion  price  will not  be adjusted  for the
issuance of Common Stock or any securities convertible into or exchangeable  for
Common Stock or carrying the right to purchase any of the foregoing.
 
OPTIONAL REDEMPTION BY ALZA
 
    The Debentures are not entitled to any sinking fund. At any time on or after
May  1, 1999, the  Debentures will be  redeemable at ALZA's  option in whole, or
from time to time  in part, on  at least 30  and not more  than 60 days'  notice
given  to the holders at  the following prices (expressed  as percentages of the
principal amount),  together,  in  each  case, with  accrued  interest  to,  but
excluding, the date fixed for redemption.
 
    If redeemed during the 12-month period beginning May 1:
 
<TABLE>
<CAPTION>
                                                                         REDEMPTION
YEAR                                                                        PRICE
- -----------------------------------------------------------------------  -----------
<S>                                                                      <C>
1999...................................................................    102.857%
2000...................................................................    102.143
2001...................................................................    101.429
2002...................................................................    100.714
2003 and thereafter....................................................    100.000
</TABLE>
 
provided that any semi-annual payment of interest becoming due on the date fixed
for  redemption shall be payable to the holders of record on the relevant record
date of  the Debentures  being redeemed;  provided further,  that ALZA  may  not
redeem  the Debentures prior to  May 1, 2000, unless  the average of the Closing
 
                                       13
<PAGE>
Prices (as defined in the Indenture) of the Common Stock for all of the  Trading
Days  (as defined in the  Indenture) during a period  of 30 consecutive calendar
days ending not more than 10 days prior to ALZA's notice to the Trustee of  such
redemption equals or exceeds 150% of the Conversion Price then in effect.
 
    If fewer than all the Debentures are to be redeemed, the Trustee will select
the  Debentures to be  redeemed pro rata or  by lot, or by  any other method not
prohibited by any stock exchange on which the Debentures are listed at the  time
of  such redemption.  If any  Debenture is to  be redeemed  in part  only, a new
Debenture or Debentures in  principal amount equal  to the unredeemed  principal
portion  thereof  will be  issued. If  a  portion of  a holder's  Debentures are
selected for partial redemption and, prior  to such redemption, such holder  has
elected to convert a portion of such Debentures, such converted portion shall be
deemed to be taken from the portion selected for redemption.
 
REPURCHASE AT OPTION OF HOLDERS UPON CHANGE IN CONTROL
 
    The  Indenture provides that if  a Change in Control  occurs, each holder of
Debentures shall  have the  right to  require  ALZA to  repurchase all  of  such
holder's  Debentures, or any portion of the  principal amount thereof that is an
integral multiple of $1,000, on the date (the "Repurchase Date") that is 30 days
after the date of  the Company Notice  (as defined below), for  cash at a  price
equal  to 100%  of the  principal amount  thereof (the  "Repurchase Price") plus
accrued and unpaid  interest to,  but excluding, the  Repurchase Date;  provided
that  any semi-annual  payment of interest  becoming due on  the Repurchase Date
shall be payable to  the holders of  record on the relevant  record date of  the
Debentures being repurchased.
 
    Within  15 days  after the  occurrence of  a Change  in Control,  ALZA or at
ALZA's request the  Trustee is obligated  to give  to all holders  of record  of
Debentures  a notice (the "Company Notice") of  the occurrence of such Change in
Control and of the repurchase right arising as a result thereof. ALZA must  also
deliver  a copy of the Company Notice to the Trustee. To exercise the repurchase
right, a holder of such Debentures must deliver to the Trustee on or before  the
30th  day after the  date of the  Company Notice written  notice of the holder's
exercise of such right, together with  the Debentures with respect to which  the
right is being exercised.
 
    A "Change in Control" will be deemed to have occurred at such time after the
original issuance of Debentures as:
 
        (i)  there is a report filed by any Person (as defined in the Indenture,
    and including any syndicate or group  deemed to be a "person" under  Section
    13(d)(3)  of the Exchange Act), other than  ALZA, any subsidiary of ALZA, or
    any employee benefit plan of ALZA or any such subsidiary, on Schedule 13D or
    14D-1 pursuant to the Exchange Act,  disclosing that such Person has  become
    the  beneficial owner, directly  or indirectly, through  a purchase or other
    acquisition transaction or series  of transactions (other  than a merger  or
    consolidation  involving  ALZA), of  shares of  capital  stock of  ALZA that
    entitle such Person to exercise in excess  of 50% of the total voting  power
    of  all shares of  capital stock of  ALZA entitled to  vote generally in the
    election of directors; or
 
        (ii) there occurs  any consolidation  of ALZA  with, or  merger of  ALZA
    into,  any other Person, any merger of another Person into ALZA, or any sale
    or transfer of all  or substantially all  of the assets  of ALZA to  another
    Person (other than (a) any such transaction pursuant to which the holders of
    the  Common Stock  immediately prior to  such transaction  have, directly or
    indirectly,  shares  of  capital  stock  of  the  continuing  or   surviving
    corporation immediately after such transaction which entitle such holders to
    exercise in excess of 50% of the total voting power of all shares of capital
    stock  of the continuing or surviving corporation entitled to vote generally
    in the election of directors and (b) any merger (1) which does not result in
    any reclassification, conversion,  exchange or  cancellation of  outstanding
    shares  of  Common Stock  or  (2) which  is  effected solely  to  change the
    jurisdiction of incorporation  of ALZA  and results  in a  reclassification,
    conversion  or exchange  of outstanding shares  of Common  Stock solely into
    shares of common stock).
 
    The term  "beneficial owner"  shall be  determined in  accordance with  Rule
13d-3  promulgated  by the  Commission  under the  Exchange  Act. To  the extent
applicable, ALZA will comply with the provisions of
 
                                       14
<PAGE>
Rule 13e-4 or any other  tender offer rules, and will  file a Schedule 13E-4  or
any  other schedule required under such rules, in connection with any repurchase
of Debentures by  ALZA at the  option of the  holders thereof upon  a Change  in
Control.
 
    The Change in Control feature of the Debentures may in certain circumstances
make  more difficult or discourage a takeover  of ALZA and, thus, the removal of
incumbent management. The  repurchase right  is not the  result of  management's
knowledge  of any effort to accumulate any  Common Stock or to obtain control of
ALZA by means of a merger, tender offer, solicitation, or otherwise, or part  of
a  plan by  management to adopt  a series of  anti-takeover provisions. Instead,
this right is the result of negotiations between ALZA and the Underwriter.
 
    ALZA's ability to repurchase Debentures upon  the occurrence of a Change  in
Control  is subject to limitations. If a  Change in Control were to occur, there
can be no  assurance that  ALZA would  have sufficient  financial resources,  or
would  be  able  to arrange  financing,  to  pay the  repurchase  price  for all
Debentures tendered by holders  thereof. Any future  credit agreements or  other
agreements  relating to  other indebtedness  (including Senior  Indebtedness) to
which ALZA becomes a party may  contain similar restrictions and provisions.  In
the  event a  Change in Control  occurs at a  time when ALZA  is prohibited from
repurchasing  Debentures,  ALZA  could  seek  the  consent  of  its  lenders  to
repurchase  the Debentures or could attempt to refinance the borrowings or lease
arrangements that  contain such  prohibition. If  ALZA does  not obtain  such  a
consent or repay such borrowings or lease arrangements, ALZA would be prohibited
under  the terms of such agreements  from repurchasing Debentures. Moreover, the
occurrence of a Change in Control or the repurchase of Debentures upon a  Change
in Control may cause an event of default under Senior Indebtedness of ALZA. As a
result,  in each case, any repurchase of  the Debentures would, absent a waiver,
be prohibited  under the  subordination provisions  of the  Indenture until  the
Senior  Indebtedness is paid in full. See "-- Subordination of Debentures" below
and "Risk  Factors --  Subordination." Any  failure by  ALZA to  repurchase  the
Debentures  when required following a Change in Control would result in an Event
of Default under the Indenture whether  or not such repurchase is prohibited  by
the  terms of  any other  agreement or  by the  subordination provisions  of the
Indenture. Any  such  default  may,  in  turn,  cause  a  default  under  Senior
Indebtedness of ALZA.
 
SUBORDINATION OF DEBENTURES
 
    Indebtedness  evidenced by the  Debentures will be  subordinated in right of
payment, as set  forth in the  Indenture, to the  prior payment in  full of  all
existing  and  future  Senior  Indebtedness.  "Senior  Indebtedness"  means  the
principal of (and premium, if any) and unpaid interest on all present and future
(i) indebtedness of ALZA for borrowed money; (ii) obligations of ALZA  evidenced
by bonds, debentures, notes or similar instruments; (iii) indebtedness incurred,
assumed  or guaranteed  by ALZA in  connection with  the acquisition by  it or a
subsidiary  of  any  business,  properties  or  assets  (except  purchase  money
indebtedness  classified as accounts payable under generally accepted accounting
principles); (iv) obligations  of ALZA  as lessee  under leases  required to  be
capitalized  on  the  balance  sheet  of  the  lessee  under  generally accepted
accounting principles and leases of property or assets made as part of any  sale
and  lease-back  transaction  to  which  ALZA  is  a  party;  (v)  reimbursement
obligations of ALZA in respect of letters of credit relating to indebtedness  of
other  obligations of  ALZA that qualify  as indebtedness or  obligations of the
kind referred to in clauses (i) through (iv) above; and (vi) obligations of ALZA
under direct or indirect guaranties  in respect of, and obligations  (contingent
or  otherwise)  to  purchase or  otherwise  acquire,  or otherwise  to  assure a
creditor against loss in  respect of, indebtedness or  obligations of others  of
the  kinds referred to in clauses (i) through (v) above, in each case unless, in
the instrument creating or evidencing the indebtedness or obligation or pursuant
to which  the same  is outstanding,  it is  provided that  such indebtedness  or
obligation is not superior in right of payment to the Debentures. The Debentures
will rank pari passu in right of payment with the outstanding LYONs.
 
    By  reason of such  subordination, in the  event of dissolution, insolvency,
bankruptcy or other similar  proceedings, upon any  distribution of assets,  (i)
the  holders of Senior Indebtedness  will be entitled to  be paid in full before
payment may be  made on the  Debentures and  the holders of  Debentures will  be
required  to  pay  over their  share  of  such distribution  in  respect  of the
Debentures to the holders of Senior Indebtedness
 
                                       15
<PAGE>
until such Senior Indebtedness is paid  in full and (ii) unsecured creditors  of
ALZA and its subsidiaries who
are  not holders of the Debentures or holders of Senior Indebtedness may recover
less, ratably,  than  holders  of  Senior Indebtedness  and  may  recover  more,
ratably, than the holders of the Debentures.
 
    No  payment of the principal,  premium, if any, or  interest with respect to
any  Debentures  (including  but  not  limited  to  the  Redemption  Price,  the
Repurchase  Price, or on account of purchase or other acquisition of Debentures)
may be made, nor may  ALZA pay cash with respect  to the purchase price or  upon
conversion  of any Debenture (other  than cash in lieu  of fractional shares) or
acquire any Debentures except as set forth in the Indenture, if there shall have
occurred and be  continuing (i) a  default in  any payment with  respect to  any
Senior  Indebtedness of  ALZA or (ii)  an event  of default with  respect to any
Senior Indebtedness of  ALZA permitting  the holders thereof  to accelerate  the
maturity thereof.
 
    As  of December  31, 1995, the  principal amount of  Senior Indebtedness was
$850,000. There  are  no  restrictions  in the  Indenture  on  the  creation  of
additional   indebtedness,  including  Senior  Indebtedness.  In  addition,  the
Debentures will be effectively subordinated to all liabilities, including  trade
payables  and capitalized lease obligations, if any, of ALZA's subsidiaries. Any
right of ALZA to receive assets of  any of its subsidiaries upon liquidation  or
reorganization of the subsidiary (and the consequent right of the holders of the
Debentures  to participate in those assets)  will be effectively subordinated to
the claims of that subsidiary's creditors (including trade creditors), except to
the extent that ALZA is itself recognized  as a creditor of such subsidiary,  in
which  case  the claims  of ALZA  would  still be  subordinated to  any security
interests in  the  assets  of  such subsidiary  and  any  indebtedness  of  such
subsidiary senior to that held by ALZA.
 
EVENTS OF DEFAULT AND REMEDIES
 
    An Event of Default is defined in the Indenture as being: default in payment
when  due of the principal  of or premium, if  any, on the Debentures (including
any failure to repurchase the Debentures  on a Repurchase Date); default for  30
days  in payment of  any installment of  interest on the  Debentures; default by
ALZA for 60  days after notice  in the  observance or performance  of any  other
covenants  in the Indenture;  failure of ALZA  to make any  payment at maturity,
including any applicable grace period,  in respect of indebtedness for  borrowed
money  of ALZA,  which payment  is in an  amount in  excess of  $30 million, and
continuance of  such failure  for 30  days after  notice; default  by ALZA  with
respect to any indebtedness for borrowed money of ALZA, which default results in
acceleration  of any such indebtedness which is in an amount of in excess of $30
million without  such indebtedness  having  been paid  or discharged,  or  there
having  been deposited  in trust  a sum  of money  sufficient to  discharge such
indebtedness, or such acceleration having been rescinded or annulled, within  30
days  after  notice;  or  certain  events  involving  bankruptcy,  insolvency or
reorganization of ALZA.  The Indenture  provides that the  Trustee may  withhold
notice  to  the holders  of  Debentures of  any  default (except  in  payment of
principal, premium, if any, or interest  with respect to the Debentures) if  the
Trustee considers it in the interest of the holders of the Debentures to do so.
 
    The  Indenture provides that if an Event  of Default shall have occurred and
be continuing, the  Trustee or the  holders of  not less than  25% in  principal
amount  of  the Debentures  then outstanding  may declare  the principal  of and
accrued interest on  the Debentures to  be due and  payable immediately, but  if
ALZA shall cure all defaults (except the nonpayment of principal of, premium, if
any,  and  interest on  any of  the Debentures  which shall  have become  due by
acceleration) and certain  other conditions  are met,  with certain  exceptions,
such  declaration may be annulled and past defaults may be waived by the holders
of a majority of the principal amount of the Debentures then outstanding. In the
case of certain events of bankruptcy or insolvency, the principal of and accrued
interest on the Debentures shall automatically become and be immediately due and
payable.
 
    The holders  of  a majority  in  principal  amount of  the  Debentures  then
outstanding  shall  have the  right  to direct  the  time, method  and  place of
conducting any proceedings for any remedy  available to the Trustee, subject  to
certain limitations specified in the Indenture.
 
MODIFICATION OF THE INDENTURE
 
    The  Indenture contains provisions permitting ALZA and the Trustee, with the
consent of the holders of  not less than a majority  in principal amount of  the
Debentures at the time outstanding, to modify the
 
                                       16
<PAGE>
Indenture  or any  supplemental indenture  or the rights  of the  holders of the
Debentures, except that no such modification shall (i) extend the fixed maturity
of any Debenture, reduce  the rate or  extend the time  for payment of  interest
thereon, reduce the principal amount thereof or premium, if any, thereon, reduce
any  amount payable  upon redemption thereof,  change the obligation  of ALZA to
repurchase any  Debenture upon  the occurrence  of any  Change in  Control in  a
manner  adverse  to holders  of  Debentures, impair  the  right of  a  holder to
institute suit  for  the payment  thereof,  change  the currency  in  which  the
Debentures are payable or impair the right to convert the Debentures into Common
Stock  subject to the terms set forth in the Indenture, or modify the provisions
of the Indenture with respect to the subordination of the Debentures in a manner
adverse to the holders  of the Debentures in  any material respect, without  the
consent  of each holder of a Debenture so affected, or (ii) reduce the aforesaid
percentage of Debentures  the holders of  which are required  to consent to  any
such  modifications, without the consent of the holders of all of the Debentures
then outstanding.
 
    Under the Indenture, ALZA, when authorized  by the resolutions of the  Board
of Directors, and the Trustee may, from time to time and at any time, enter into
an  indenture  or  supplemental indentures  for  one  or more  of  the following
purposes: (i) to  make provision with  respect to the  conversion rights of  the
holders  of the Debentures or the repurchase  obligations of ALZA, in each case,
pursuant to the terms of the Indenture; (ii) subject to the subordination of the
Debentures, to convey, transfer,  assign, mortgage or pledge  to the Trustee  as
security  for  the Debentures,  any property  or assets;  (iii) to  evidence the
succession of another corporation  to ALZA, or  successive successions, and  the
assumption  by  the  successor  corporation  of  the  covenants,  agreements and
obligations  of  ALZA  pursuant  to  the  Indenture;  (iv)  subject  to  certain
limitations,   to  add  to  the  covenants   of  ALZA  such  further  covenants,
restrictions or conditions as ALZA and the Trustee shall consider to be for  the
benefit  of the holders  of the Debentures,  and to make  the occurrence, or the
occurrence and continuance, of  a Default (as defined  in the Indenture) in  any
such  additional covenants, restrictions or conditions  a Default or an Event of
Default (as defined in the Indenture)  permitting the enforcement of all or  any
of  the several remedies provided in the Indenture; (v) to cure any ambiguity or
to correct or  supplement any  provision contained in  the Indenture  or in  any
supplemental  indenture which  may be defective  or inconsistent  with any other
provision contained in  the Indenture or  in any supplemental  indenture, or  to
make  such other provisions in regard to  matters or questions arising under the
Indenture which shall  not adversely affect  the interest of  any holder of  the
Debentures; or (vi) to evidence and provide for the acceptance of appointment by
a successor Trustee with respect to the Debentures.
 
LIMITATION ON MERGER, SALE OR CONSOLIDATION
 
    ALZA  shall not consolidate or  merge with or into  any other corporation or
corporations  or,  directly  or  indirectly,  sell,  convey  or  lease  all   or
substantially  all  of its  property to  any other  corporation (whether  or not
affiliated with ALZA) unless the surviving or successor corporation in the event
of a merger or consolidation, or the corporation to which a sale, conveyance  or
lease  is made  (i) is an  entity organized and  existing under the  laws of the
United States, any state thereof or the District of Columbia and (ii)  expressly
assumes  by  supplemental  indenture  all  the  obligations  of  ALZA  under the
Debentures and the Indenture.
 
DISCHARGE OF INDENTURE
 
    ALZA may terminate substantially all of its obligations under the  Indenture
at  any  time  by  delivering  all outstanding  Debentures  to  the  Trustee for
cancellation and paying any other sums payable under the Indenture.
 
CONCERNING THE TRUSTEE
 
    The Chase Manhattan  Bank, N.A., as  Trustee under the  Indenture, has  been
appointed  by ALZA  as the paying  agent, conversion  agent, registrar, transfer
agent and custodian with regard to the Debentures. The Trustee or its affiliates
may from time to time in the  future provide banking and other services to  ALZA
in the ordinary course of its business.
 
GOVERNING LAW
 
    The  Indenture  and the  Debentures  will be  governed  by and  construed in
accordance with the laws of the State of New York.
 
                                       17
<PAGE>
                          DESCRIPTION OF CAPITAL STOCK
 
    ALZA's authorized capital  stock consists  of 300,000,000  shares of  Common
Stock,  par value  $.01 per  share, and 100,000  shares of  Preferred Stock, par
value $.01 per share (the "Preferred Stock"). No Preferred Stock is  outstanding
as of the date of this Prospectus. For recent prices of Common Stock, see "Price
Range of Common Stock and Dividend Policy."
 
    On  December  31,  1995,  there  were  82,506,419  shares  of  Common  Stock
outstanding. In addition there were  (i) 4,863,868 shares reserved for  issuance
pursuant to ALZA's stock option and stock purchase plans; (ii) 12,321,416 shares
reserved  for  issuance  upon  conversion of  the  LYONs;  (iii)  966,803 shares
reserved for issuance upon the  exercise of outstanding warrants exercisable  at
$65  per share  on or  before December  31, 1999  issued in  connection with the
formation of TDC; (iv) 1,000,000 shares  reserved for issuance upon exercise  of
outstanding  warrants exercisable at $25 per share on or before January 31, 1996
(which warrants  were  exercised  subsequent  to December  31,  1995);  and  (v)
11,390,416  shares  reserved  for  issuance upon  conversion  of  the Debentures
(13,098,979 shares if the over-allotment option is exercised in full).
 
    Holders of Common Stock are entitled to one vote for each share held on  all
matters  submitted to a vote of stockholders.  Subject to any superior rights of
Preferred Stock, holders of Common  Stock are entitled to  share, on a pro  rata
basis,  in all assets  remaining after payment of  or provision for liabilities.
The shares of Common Stock are not subject to redemption. ALZA has the corporate
power to repurchase Common Stock.
 
    ALZA's Board  of  Directors  has  authority to  fix  or  alter  the  rights,
preferences, privileges, restrictions and other terms of any series of Preferred
Stock,  the number  of shares constituting  any such series  and the designation
thereof. ALZA has no present plans to issue any shares of Preferred Stock.
 
    ALZA has a classified  Board of Directors  with directors serving  staggered
terms  of three  years each.  Directors may not  be removed  by the stockholders
without cause. Special meetings  of the stockholders may  be called only by  the
Board  of Directors, the Chairman of the Board or the President. Nominations for
election of  directors  may  be  made  by the  Board  of  Directors  or  by  any
stockholder  of  record  entitled  to  vote  for  directors,  provided  that any
stockholder nominating a candidate for  director must deliver written notice  to
the Secretary of ALZA not later than the close of business 60 days in advance of
the  stockholders' meeting  or 10  days after  the date  on which  the notice of
meeting is first given  to stockholders, whichever  is later. The  stockholder's
notice  must set  forth certain information  concerning the  stockholder and the
stockholder's nominee. No  nominations for  director shall be  presented to  any
stockholders'  meeting if  not made in  compliance with  such procedures. ALZA's
bylaws also require that advance notice be given and certain other procedures be
followed with regard to any other business to be brought by a stockholder before
a meeting of  stockholders. Such procedures  include the delivery  of notice  of
such  proposal to the Secretary of ALZA not  later than the close of business 60
days in advance of the meeting or 10 days after the date on which the notice  of
meeting  is first given to stockholders, whichever is later. The notice must set
forth certain information concerning the stockholder and the proposed  business,
including  any  material  interest  of the  stockholder  in  that  business. The
provisions of  ALZA's  Certificate of  Incorporation  and bylaws  governing  the
number  and classification of the Board of Directors and certain related matters
cannot be amended without the approval of at least 75% of the Board of Directors
or the  affirmative vote  of  not less  than  80% of  the  voting power  of  the
outstanding shares of voting capital stock. The affirmative vote of at least 80%
of  the  voting power  of  the outstanding  shares  of voting  capital  stock is
required to approve certain business combinations.
 
    The provisions of ALZA's Certificate of Incorporation granting the Board  of
Directors  the authority to issue  Preferred Stock with such  terms as the Board
may determine, classifying  ALZA's Board, preventing  stockholders from  calling
special  meetings of ALZA's  stockholders, and requiring  supermajority votes in
the event of certain business combinations may inhibit any change in control  of
ALZA.
 
                                       18
<PAGE>
                   CERTAIN FEDERAL INCOME TAX CONSIDERATIONS
 
    The  following  is a  general discussion  of  certain United  States federal
income tax considerations relevant to holders of the Debentures. This discussion
is based  upon the  Internal Revenue  Code  of 1986,  as amended  (the  "Code"),
Treasury  Regulations, Internal  Revenue Service  ("IRS") rulings,  and judicial
decisions now  in effect,  all of  which are  subject to  change (possibly  with
retroactive  effect)  or  different interpretations.  This  discussion  does not
purport to deal with all aspects of federal income taxation that may be relevant
to a particular investor's  decision to purchase the  Debentures, and it is  not
intended  to be wholly applicable to all categories of investors, some of which,
such  as  dealers   in  securities,  banks,   insurance  companies,   tax-exempt
organizations and non-United States persons, may be subject to special rules. In
addition,  this discussion is limited to persons that purchase the Debentures in
this offering and hold the Debentures as "capital assets" within the meaning  of
Section 1221 of the Code.
 
    ALL  PROSPECTIVE PURCHASERS OF  THE DEBENTURES ARE  ADVISED TO CONSULT THEIR
OWN  TAX  ADVISORS  REGARDING  THE   FEDERAL,  STATE,  LOCAL  AND  FOREIGN   TAX
CONSEQUENCES  OF THE PURCHASE,  OWNERSHIP AND DISPOSITION  OF THE DEBENTURES AND
THE COMMON STOCK.
 
CONVERSION OF DEBENTURES INTO COMMON STOCK
 
    In general,  no gain  or loss  will  be recognized  for federal  income  tax
purposes on a conversion of the Debentures into shares of Common Stock. However,
cash  paid by  ALZA in lieu  of a fractional  share of Common  Stock will likely
result in taxable gain (or loss), which  will be capital gain (or loss), to  the
extent  that the amount of such cash exceeds  (or is exceeded by) the portion of
the adjusted basis  of the  Debenture allocable  to such  fractional share.  The
adjusted  basis of shares of Common Stock  received on conversion will equal the
adjusted basis of the  Debenture converted, reduced by  the portion of  adjusted
basis  allocated to any fractional share of Common Stock exchanged for cash. The
holding period  of a  holder in  the Common  Stock received  on conversion  will
include the period during which the converted Debentures were held.
 
    The  Conversion  Price  of the  Debentures  is subject  to  adjustment under
certain  circumstances.  See  "Description   of  Debentures  --  Conversion   of
Debentures."  Section  305  of  the Code  and  the  Treasury  Regulations issued
thereunder may  treat  the  holders  of the  Debentures  as  having  received  a
constructive  distribution if and to the  extent that certain adjustments in the
Conversion Price  that  may  occur in  limited  circumstances  (particularly  an
adjustment  to reflect a  taxable dividend to holders  of Common Stock) increase
the proportionate interest of a holder of Debentures in the fully diluted Common
Stock, whether or not such holder ever exercises its conversion privilege. As  a
result  of such a  constructive distribution the holders  of Debentures may have
ordinary income to the extent of ALZA's  current earnings and profits as of  the
end  of the taxable  year to which the  constructive distribution relates and/or
ALZA's accumulated  earnings and  profits.  Moreover, if  there  is not  a  full
adjustment to the Conversion Price of the Debentures to reflect a stock dividend
or  other  event  increasing  the  proportionate  interest  of  the  holders  of
outstanding Common Stock  in the assets  or earnings and  profits of ALZA,  then
such  increase in the proportionate interest of  the holders of the Common Stock
generally will be treated as a distribution to such holders, taxable as ordinary
income to the extent of ALZA's current earnings and profits as of the end of the
taxable year  to  which  the constructive  distribution  relates  and/or  ALZA's
accumulated earnings and profits.
 
SALE, EXCHANGE OR RETIREMENT OF DEBENTURES
 
    Each  holder of  Debentures generally will  recognize gain or  loss upon the
sale, exchange, redemption, repurchase,  retirement or other disposition  (other
than  conversion) of the Debentures measured  by the difference (if any) between
(i) the  amount of  cash and  the fair  market value  of any  property  received
(except  to the extent that  such cash or other  property is attributable to the
payment of accrued interest not previously included in income, which amount will
be taxable as ordinary income) and (ii) the holder's adjusted tax basis in those
Debentures (including any market discount  previously included in income by  the
holder).  Each  holder  of  the  Common  Stock  into  which  the  Debentures are
converted, in general,  will recognize  gain or  loss upon  the sale,  exchange,
redemption,  or  other  disposition of  the  Common Stock  measured  under rules
similar to those described in the preceding sentence for the Debentures. Special
rules may apply  to redemptions of  Common Stock which  may result in  different
treatment. Any such gain or
 
                                       19
<PAGE>
loss  recognized on  the sale,  exchange, redemption,  repurchase, retirement or
other disposition of a Debenture or share of Common Stock should, in general, be
capital gain or  loss, which  would be  long-term capital  gain or  loss if  the
Debenture or the Common Stock was held for more than one year at the time of the
disposition. A holder's initial basis in a Debenture will be the cash price paid
therefor.
 
BACK-UP WITHHOLDING
 
    A  holder  of  Debentures  or  Common  Stock  may  be  subject  to  "back-up
withholding" from a reportable payment at a  rate of 31 percent if, among  other
things,  (i)  the holder  fails to  furnish  a social  security number  or other
taxpayer identification  number ("TIN")  to ALZA  certified under  penalties  of
perjury  within  a reasonable  time  after the  request  therefor; (ii)  the IRS
notifies ALZA that the TIN furnished by  the holder is incorrect; (iii) the  IRS
notifies ALZA that backup withholding should be commenced because the holder has
failed to properly report interest or dividends; or (iv) when required to do so,
the  holder fails to certify under penalties  of perjury that such holder is not
subject to  backup withholding  or that  the TIN  provided to  ALZA is  correct.
Reportable  payments  include interest  payments,  dividend payments  and, under
certain circumstances, principal payments on  the Debentures. A holder who  does
not  provide ALZA with its correct TIN  also may be subject to penalties imposed
by the IRS. Any  amount withheld from  a payment to a  holder under the  back-up
withholding  rules  is  creditable  against  the  holder's  federal  income  tax
liability. Back-up withholding will not apply, however, with respect to payments
made to certain  holders, including corporations,  tax-exempt organizations  and
certain  foreign persons, provided  their exemption from  back-up withholding is
properly established.
 
    ALZA will report to the  holders of Debentures and  Common Stock and to  the
IRS  the amount  of any  "reportable payments"  for each  calendar year  and the
amount of tax withheld, if any, with respect to such payments.
 
                                       20
<PAGE>
                                  UNDERWRITING
 
    Merrill Lynch, Pierce, Fenner &  Smith Incorporated (the "Underwriter")  has
agreed,  subject  to the  terms  and conditions  of  the Purchase  Agreement, to
purchase $435,000,000 aggregate  principal amount of  the Debentures from  ALZA.
The  Underwriter  has advised  ALZA  that it  proposes  to offer  the Debentures
directly to the public at the offering price set forth on the cover page of this
Prospectus. After  the  initial  public  offering, the  offering  price  may  be
changed.  The Debentures  are offered subject  to receipt and  acceptance by the
Underwriter and  to certain  other  conditions, including  the right  to  reject
orders in whole or in part.
 
    ALZA  has granted the  Underwriter an option, exercisable  for 30 days after
the date  of  this Prospectus,  to  purchase  up to  an  additional  $65,250,000
principal  amount of Debentures to cover over-allotments, if any, at the initial
public offering price less the underwriting  discount as set forth on the  cover
page of this Prospectus.
 
    ALZA  has agreed to  indemnify the Underwriter  against certain liabilities,
including liabilities under the  Securities Act, and  to contribute to  payments
the Underwriter may be required to make in respect thereof.
 
    ALZA  has agreed with the Underwriter not  to sell, offer to sell, grant any
option for  the sale  of, or  otherwise dispose  of or  transfer any  securities
similar to the Debentures or any Common Stock or any securities convertible into
or  exercisable or exchangeable for such securities or Common Stock for a period
of 90 days after the date of  this Prospectus without the prior written  consent
of  the Underwriter other  than (i) Common  Stock issuable upon  the exchange of
Debentures offered hereby; (ii) Common Stock issued or sold pursuant to employee
benefit plans and dividend  reinvestment plans; (iii)  Common Stock issued  upon
exercise  of currently outstanding options,  warrants or convertible securities;
(iv) certain privately issued restricted securities; or (v) Common Stock  issued
in  connection with investments in, acquisitions  of, or mergers or combinations
with other companies.
 
    The Debentures  have  been  approved  for listing  on  the  New  York  Stock
Exchange, subject to official notice of issuance.
 
    From  time  to  time the  Underwriter  and  certain of  its  affiliates have
performed, and  may  in the  future  perform, investment  banking  or  financial
advisory services for ALZA.
 
                                 LEGAL MATTERS
 
    The  validity of the  issuance of the Debentures  offered hereby and certain
legal matters with respect  to United States  federal income tax  considerations
will  be passed  upon for ALZA  by Heller  Ehrman White &  McAuliffe, Palo Alto,
California, ALZA's counsel. Skadden, Arps,  Slate, Meagher & Flom, Los  Angeles,
California,  will act as counsel to the Underwriter. Julian N. Stern, a director
and the Secretary of ALZA,  is a member of Heller  Ehrman White & McAuliffe.  At
April  1, 1996, attorneys  in that firm  involved in the  representation of ALZA
owned beneficially  138,379  shares  of Common  Stock  (including  options,  but
excluding warrants to purchase Common Stock).
 
                                    EXPERTS
 
    The  consolidated financial  statements and financial  statement schedule of
ALZA Corporation appearing or incorporated by reference in ALZA's Annual  Report
(Form  10-K) for the year ended December 31,  1995, have been audited by Ernst &
Young LLP, independent auditors, as set forth in their reports thereon  included
or  incorporated by reference therein and incorporated herein by reference. Such
consolidated  financial  statements   and  financial   statement  schedule   are
incorporated  herein by reference  in reliance upon such  reports given upon the
authority of such firm as experts in accounting and auditing.
 
                                       21
<PAGE>
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    NO  DEALER, SALESPERSON OR OTHER INDIVIDUAL  HAS BEEN AUTHORIZED TO GIVE ANY
INFORMATION OR  MAKE ANY  REPRESENTATIONS NOT  CONTAINED IN  THIS PROSPECTUS  IN
CONNECTION  WITH THE OFFERING COVERED BY THIS PROSPECTUS. IF GIVEN OR MADE, SUCH
INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED
BY ALZA OR  THE UNDERWRITER.  THIS PROSPECTUS DOES  NOT CONSTITUTE  AN OFFER  TO
SELL,  OR  A SOLICITATION  OF AN  OFFER TO  BUY, ANY  SECURITIES OTHER  THAN THE
REGISTERED SECURITIES TO WHICH  IT RELATES, OR AN  OFFER OR SOLICITATION IN  ANY
JURISDICTION  WHERE, OR TO ANY PERSON TO WHOM, IT IS UNLAWFUL TO MAKE SUCH OFFER
OR SOLICITATION.  NEITHER THE  DELIVERY OF  THIS PROSPECTUS  NOR ANY  SALE  MADE
HEREUNDER  SHALL, UNDER ANY CIRCUMSTANCES, CREATE  AN IMPLICATION THAT THERE HAS
NOT BEEN ANY CHANGE IN THE FACTS SET FORTH IN THIS PROSPECTUS OR IN THE  AFFAIRS
OF ALZA SINCE THE DATE HEREOF.
 
                            ------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    -----
<S>                                              <C>
Available Information..........................           2
Incorporation of Certain Documents by
 Reference.....................................           2
Prospectus Summary.............................           3
Risk Factors...................................           7
Use of Proceeds................................           9
Price Range of Common Stock and Dividend
 Policy........................................           9
Capitalization.................................          10
Description of Debentures......................          11
Description of Capital Stock...................          18
Certain Federal Income Tax Considerations......          19
Underwriting...................................          21
Legal Matters..................................          21
Experts........................................          21
</TABLE>
 
                                  $435,000,000
 
                                     [LOGO]
 
                          5% CONVERTIBLE SUBORDINATED
                              DEBENTURES DUE 2006
 
                            ------------------------
 
                                   PROSPECTUS
 
                            ------------------------
 
                              MERRILL LYNCH & CO.
 
                                 APRIL 23, 1996
 
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