ALZA CORP
SC 13E3/A, 1997-09-05
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC 20549
                                 _____________

                                SCHEDULE 13E-3

                               (Amendment No. 1)

                       RULE 13E-3 TRANSACTION STATEMENT

      (PURSUANT TO SECTION 13(e) OF THE SECURITIES EXCHANGE ACT OF 1934)

                       THERAPEUTIC DISCOVERY CORPORATION
- --------------------------------------------------------------------------------
                             (Name of the Issuer)

                               ALZA CORPORATION
- --------------------------------------------------------------------------------
                     (Name of Person(s) Filing Statement)

                     CLASS A COMMON STOCK, PAR VALUE $0.01
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)

                                   883376105
- --------------------------------------------------------------------------------
                     (CUSIP Number of Class of Securities)

    Bruce Cozadd, 950 Page Mill Road, Palo Alto, CA  94304, (650) 494-5000
- --------------------------------------------------------------------------------
  (Name, Address and Telephone Number of Person Authorized to Receive Notices
          and Communications on Behalf of Person(s) Filing Statement)

This statement is filed in connection with (check the appropriate box):

(a)   [ ]    The filing of solicitation materials or an information statement
             subject to Regulation 14A, Regulation 14C, or Rule 13e-3(c) under
             the Securities Exchange Act of 1934.

(b)   [ ]    The filing of a registration statement under the Securities Act of
             1933.

(c)   [ ]    A tender offer.

(d)   [X]    None of the above.

Check the following box if the soliciting materials or information statement
referred to in checking box (a) are preliminary copies. [ ]

                           Calculation of Filing Fee
- --------------------------------------------------------------------------------
Transaction Valuation/1/:  $100 million        Amount of Filing Fee/2/:  $20,000
- --------------------------------------------------------------------------------

- -----------------------
     /1/ For purposes of calculating the filing fee only. This calculation is
based upon the purchase price of $100 million for all issued and outstanding
shares of Class A Common Stock of the Issuer to be acquired pursuant to this 
transaction.

     /2/ The amount of the filing fee, calculated in accordance with Section
13 of the Securities Exchange Act of 1934, as amended, equals 1/50th of one
percent of the aggregate value of cash to be paid by ALZA Corporation for such
Class A Common Stock.
<PAGE>
 
[X]  Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
and identify the filing with which the offsetting fee was previously paid.
Identify the previous filing by registration statement number, or the form or
schedule and the date of its filing.

Amount previously paid:      $20,000          Filing party:  ALZA Corporation
                         -----------------                    -----------------
                       
Form or registration no.:  Schedule 13E3       Date filed:   August 27, 1997
                         -----------------                   ------------------ 


                                       2
<PAGE>
 
Introduction.
- -------------

     This Amendment No. 1 to Schedule 13E-3 Transaction Statement (the
"Statement") relates to the exercise by ALZA Corporation, a Delaware corporation
("ALZA"), of its option to purchase all issued and outstanding shares of Class A
Common Stock of Therapeutic Discovery Corporation, a Delaware corporation
("TDC").

     This Statement is being filed by ALZA. Notwithstanding this Statement,
ALZA does not admit that the transaction reported herein is subject to the
application of Rule 13e-3 under the Securities Exchange Act of 1934, as
amended.

Item 7.
- -------

     (a)  The purpose of this transaction is to acquire the rights to all
          products and product candidates developed or under development by ALZA
          and TDC pursuant to the Development Agreement dated March 10, 1993
          between ALZA and TDC. ALZA believes that it is in the best interests
          of ALZA and ALZA's stockholders to exercise the Purchase Option at
          this time.

     (b)  ALZA holds options to license individual products of TDC. However,
          compared to the purchase of all of the issued and outstanding Class A
          Common Stock of TDC, the exercise of individual license options was
          not considered by ALZA to be the most effective and comprehensive
          means to acquire all of TDC's products and product candidates.

     (c)  The transaction is structured pursuant to the terms of the previously
          granted Purchase Option as set forth in TDC's Restated Certificate.  
          This transaction is being undertaken at this time because TDC has no
          significant funds remaining to expend on product development and the
          Purchase Option otherwise would have expired no later than January 15,
          1998.

                                       3
<PAGE>

     (d)  The transaction reported herein will cause TDC to become a wholly-
          owned subsidiary of ALZA. TDC will be de-listed from the Nasdaq
          National Market and will have its public reporting obligations
          suspended. The federal tax consequences to TDC are that utilization of
          TDC's losses and other tax carryovers may be limited under Section 382
          of the Internal Revenue Code of 1986, as amended (the "Code").

          The transaction reported herein will cause ALZA to own 100% of TDC.
          As a result, ALZA will indirectly own all of the assets of TDC.
          Accordingly, ALZA will report 100% of the net book value and net
          earnings of TDC. There will be no significant federal tax
          consequences to ALZA as a result of the exercise of the Purchase
          Option.

          The transaction reported herein will cause each stockholder of Class A
          Common Stock to dispose of his or her Class A Common Stock for
          consideration equal to that stockholder's pro rata share of the
          exercise price identified in Item 4(a) above.  This consideration is
          the amount specified in the Restated Certificate provided in 1993.
          The federal income tax consequences to such stockholder, in general
          terms, are set forth below.

          The following discussion sets forth federal income tax considerations
          under the Code for stockholders with respect to cash received by
          stockholders of TDC for the Class A Common Stock. This discussion is
          intended only to provide general information to stockholders that are
          subject to United States federal income tax; it may not address all
          relevant federal income tax consequences to such persons or to other
          categories of stockholders, e.g., foreign persons, dealers in
          securities, and stockholders that are exempt from federal income tax.
          This discussion is based upon present federal income tax laws and does
          not attempt to anticipate changes, including changes in tax rates,
          that may be made under currently pending legislative proposals. This
          discussion assumes that the Class A Common Stock was at all relevant
          times capital assets of the stockholders. This discussion does not
          address state, local or foreign tax considerations. ALL STOCKHOLDERS
          ARE URGED TO CONSULT THEIR OWN TAX ADVISORS.

          Holders of Class A Common Stock will have a capital gain or loss due
          to ALZA's exercise of the Purchase Option equal to the difference
          between (a)

                                       4
<PAGE>
 
          the amount of the cash received, and (b) their basis in the Class A
          Common Stock surrendered. Gain or loss due to the exercise of the
          Purchase Option should be long-term if the Class A Common Stock has
          been held for more than one year at the time of exercise of the
          Purchase Option. The Internal Revenue Service ("IRS") may assert,
          however, that the holding period of the Class A Common Stock does not
          begin until such date as the Purchase Option is exercised and that
          capital gain or loss upon exercise of the Purchase Option is therefore
          short-term. Limitations may apply to deduction of capital loss.

          To the extent that holders of Class A Common Stock have not provided
          appropriate taxpayer identification numbers on IRS Form W-9 or a
          substitute therefor, such stockholders may be subject to backup
          withholding by ALZA.

Item 8.
- -------

     (a)  ALZA reasonably believes that the transaction reported herein is fair
          to the holders of TDC Class A Common Stock.  None of ALZA's directors
          dissented to the transaction.  Julian N. Stern and Dr. Alejandro
          Zaffaroni abstained from voting on such transaction because they each
          own shares of Class A Common Stock.

     (b)  The material factor upon which the belief stated in Item 8(a) is based
          is set forth below.

               (i)   Stockholder Awareness of Purchase Option

               The initial public holders of the Class A Common Stock received
               such stock as a dividend from ALZA in 1993. The Purchase Option
               was a feature of the Class A Common Stock at that time and was
               described in the ALZA Information Statement, dated March 10,
               1993, distributed in connection with this distribution. The
               Purchase Option was also set forth in the Restated Certificate,
               which was publicly filed both with the Delaware Secretary of
               State and the Commission prior to the distribution. Pursuant to
               the Restated Certificate, the stock certificates for the Class
               A Common Stock were legended to put the holders thereof on
               further notice about the Purchase Option. Stockholders were
               also advised of the Purchase Option in each Form 10-K (since
               the date of the distribution) and each recent Form 10-Q public
               filing made by each of ALZA and TDC with the Commission.
               Accordingly, the Purchase Option was present in the initial
               public distribution of the Class A Common Stock, was
               disseminated in TDC's charter documents, was discussed

                                       5
<PAGE>
 
               in ALZA's and TDC's periodic filings and was legended on each
               stock certificate for the Class A Common Stock. As a result,
               every TDC Class A Common stockholder received substantial
               notice as to the terms of the Purchase Option prior to making
               any investment decision with respect to the Class A Common
               Stock. In addition, recent public filings by both ALZA and TDC
               have indicated the status of funds available for product
               development and therefore when the potential exercise of the
               Purchase Option was likely to be triggered. During 1997, both
               parties have indicated that these funds would likely be
               exhausted during the third quarter of 1997.

               ALZA decided to exercise the Purchase Option at this time because
               TDC's Available Funds were exhausted in the third quarter of 1997
               as anticipated, and TDC had no further funding available to
               expend on products and product development. Accordingly, ALZA
               exercised the Purchase Option in order to continue product
               development without interruption.

               ALZA decided to pay the exercise price to TDC Class A Common
               stockholders in cash because ALZA had sufficient available cash,
               cash provides immediately liquid proceeds at a readily determined
               value and a payment of cash would not be dilutive to the value of
               existing ALZA stockholders. ALZA reasonably believes the form of
               such payment to be fair to TDC Class A Common stockholders.


                                       6
<PAGE>
 

     (c)  The Restated Certificate does not require any approval of the
          stockholders of TDC for the exercise of the Purchase Option.

     (d)  After making reasonable inquiry of management of TDC, ALZA believes
          that no directors of TDC have retained an unaffiliated representative
          to act solely on behalf of any security holders of TDC as no action is
          required by either TDC's directors or security holders to effect the
          Purchase Option.

     (e)  See Item 8(d) above.
 
     (f)  Not applicable.


Item 17.
- --------

     17(d) Notice to Stockholders of Therapeutic Discovery Corporation (for
purposes of this Statement only, Annex A thereto being Item 17(c) to the
Schedule 13E-3 filed by ALZA Corporation on August 27, 1997).

                                       7
<PAGE>
 
                                   SIGNATURE

     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

September 5, 1997                        ALZA CORPORATION


                                         By: /s/ PETER D. STAPLE
                                            ----------------------------
                                              Peter D. Staple,
                                              Senior Vice President and
                                              General Counsel



The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative.  If the statement is signed
on behalf of a person by his authorized representative (other than an executive
officer or general partner of the person filing this statement), evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement.  The name and any title of each person who signs the statement
shall be typed or printed beneath his signature.
<PAGE>
 
                                                                     ANNEX 17(d)

- --------------------------------------------------------------------------------

                               ALZA CORPORATION

                      EXERCISE OF OPTION TO PURCHASE ALL
                            CLASS A COMMON STOCK OF
                       THERAPEUTIC DISCOVERY CORPORATION

                     ------------------------------------
 
                          NOTICE  TO  STOCKHOLDERS OF

                       THERAPEUTIC DISCOVERY CORPORATION

                     ------------------------------------


        This information is disseminated pursuant to Rule 13e-3 of the
                 Securities Exchange Act of 1934, as amended.


THIS TRANSACTION HAS NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
 EXCHANGE COMMISSION NOR HAS THE COMMISSION PASSED UPON THE FAIRNESS OR MERITS
 OF SUCH TRANSACTION NOR UPON THE ACCURACY OR ADEQUACY OF THE INFORMATION
 CONTAINED IN THIS DOCUMENT. ANY REPRESENTATION TO THE CONTRARY IS UNLAWFUL.
  
 
 
- --------------------------------------------------------------------------------
<PAGE>
 

                                THE TRANSACTION
                                ---------------

     ALZA Corporation, a Delaware corporation ("ALZA"), wishes to advise holders
of the Class A Common Stock of Therapeutic Discovery Corporation, a Delaware
corporation ("TDC"), that, on August 25, 1997, ALZA exercised its option to
purchase all of the issued and outstanding shares of Class A Common Stock of TDC
(the "Purchase Option") as provided in TDC's Restated Certificate of
Incorporation filed with the Secretary of State of the State of Delaware on
April 1, 1993 (the "Restated Certificate"). The closing date for this purchase
will be September 29, 1997 (the "Closing Date"). A copy of the Restated
Certificate is appended hereto as Annex A.
                                  ------- 

     The purchase price for all issued and outstanding shares of Class A
Common Stock is $100 million. As of August 25, 1997, there are 7,734,424
shares of Class A Common Stock issued and outstanding and options to purchase
395,000 shares of Class A Common Stock currently exercisable. Accordingly,
assuming all outstanding options are exercised, you will receive approximately
$12.30 for each share of Class A Common Stock that you hold as of the close of
business on the Closing Date.

     In accordance with the Restated Certificate, ALZA will deposit $100
million with Boston EquiServe, L.P. (the "Payment Agent") on or before
September 29, 1997 and will provide the Payment Agent with an irrevocable
direction to pay these funds to the holders as of the close of business on
September 29, 1997 of Class A Common Stock. AFTER COMPLYING WITH THESE
CONDITIONS, OWNERSHIP OF ALL TDC CLASS A COMMON STOCK WILL AUTOMATICALLY
TRANSFER TO ALZA ON SEPTEMBER 29, 1997. If you hold your Class A Common Stock
certificates, the Payment Agent will be instructing you on how to tender your
certificates for payment. You will receive your payment from the Payment Agent
after you tender the certificates. If you hold your Class A Common Stock in a
brokerage account, your broker will credit your account with the purchase
price.

<PAGE>
 
                              NATURE OF DISCLOSURE
                              --------------------

     ALZA is providing this information to the security holders of TDC in
compliance with Rule 13e-3 of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"). Notwithstanding the provision of this information, ALZA
does not admit that it is an "affiliate" of TDC as such term is used in Rule 
13e-3 of the Exchange Act.

                                SPECIAL FACTORS
                                ---------------

     Purpose
     -------

     The purpose of this transaction is to acquire the rights to all products
and product candidates developed or under development by ALZA and TDC pursuant
to the Development Agreement dated March 10, 1993 between ALZA and TDC. ALZA
believes that it is in the best interests of ALZA and ALZA's stockholders to
exercise the Purchase Option at this time.

        ALZA holds options to license individual products of TDC. However, 
compared to the purchase of all of the issued and outstanding Class A Common 
Stock of TDC, the exercise of individual license options was not considered by 
ALZA to be the most effective and comprehensive means to acquire all of TDC's 
products and product candidates.

     The transaction is structured pursuant to the terms of the previously
granted Purchase Option as set forth in TDC's Restated Certificate. This
transaction is being undertaken at this time because TDC has no significant
funds remaining to expend on product development and the Purchase Option
otherwise would have expired no later than January 15, 1998.

     Consequences
     ------------

     The transaction reported herein will cause TDC to become a wholly-owned
subsidiary of ALZA. ALZA anticipates that TDC will be de-listed from the
Nasdaq National Market and will have its public reporting obligations
suspended. The federal tax consequences to TDC are that utilization of TDC's
losses and other tax carryovers may be limited under Section 382 of the
Internal Revenue Code of 1986, as amended (the "Code").

     The transaction reported herein will cause ALZA to own 100% of TDC. As a
result, ALZA will indirectly own all of the assets of TDC. Accordingly, ALZA
will report 100% of the net book value and net earnings of TDC. There will be
no significant federal tax consequences to ALZA as a result of the exercise of
the Purchase Option.

                                       3
<PAGE>
 
     The transaction reported herein will cause each stockholder of Class A
Common Stock to dispose of his or her Class A Common Stock for consideration
equal to that stockholder's pro rata share of the exercise price identified
above.  This consideration is the amount specified in the Restated Certificate
provided in 1993.  The federal income tax consequences to such stockholder, in
general terms, are set forth below.

     The following discussion sets forth federal income tax considerations under
the Code for stockholders with respect to cash received by stockholders for the
Class A Common Stock. This discussion is intended only to provide general
information to stockholders that are subject to United States federal income
tax; it may not address all relevant federal income tax consequences to such
persons or to other categories of stockholders, e.g., foreign persons, dealers
in securities, and stockholders that are exempt from federal income tax. This
discussion is based upon present federal income tax laws and does not attempt to
anticipate changes, including changes in tax rates, that may be made under
currently pending legislative proposals. This discussion assumes that the Class
A Common Stock was at all relevant times capital assets of the stockholders.
This discussion does not address state, local or foreign tax considerations. ALL
STOCKHOLDERS ARE URGED TO CONSULT THEIR OWN TAX ADVISORS.

     Holders of Class A Common Stock will have a capital gain or loss due to
ALZA's exercise of the Purchase Option equal to the difference between (a) the
amount of the cash received, and (b) their basis in the Class A Common Stock
surrendered. Gain or loss due to the exercise of the Purchase Option should be
long-term if the Class A Common Stock has been held for more than one year at
the time of exercise of the Purchase Option. The Internal Revenue Service
("IRS") may assert, however, that the holding period of the Class A Common
Stock does not begin until such date as the Purchase Option is exercised and
that capital gain or loss upon exercise of the Purchase Option is therefore
short-term. Limitations may apply to deduction of capital loss.

     To the extent that holders of Class A Common Stock have not provided
appropriate taxpayer identification numbers on IRS Form W-9 or a substitute
therefor, such stockholders may be subject to backup withholding by ALZA.

          Fairness
          --------

     ALZA reasonably believes that the transaction reported herein is fair to
the holders of TDC Class A Common Stock. None of ALZA's directors dissented to
the transaction. 

                                       4
<PAGE>
 
Julian N. Stern and Dr. Alejandro Zaffaroni abstained from voting on such
transaction because they each own shares of Class A Common Stock.

     The material factor upon which this belief is based is set forth below.

     Stockholder Awareness of Purchase Option

     The initial public holders of the Class A Common Stock received such stock
     as a dividend from ALZA in 1993. The Purchase Option was a feature of the
     Class A Common Stock at that time and was described in the ALZA Information
     Statement dated March 10, 1993 distributed in connection with this
     distribution. The Purchase Option was also set forth in the Restated
     Certificate, which was publicly filed both with the Delaware Secretary of
     State and the Securities and Exchange Commission (the "Commission") prior
     to the distribution. Pursuant to the Restated Certificate, the stock
     certificates for the Class A Common Stock were legended to put the holders
     thereof on further notice about the Purchase Option. Stockholders were also
     advised of the Purchase Option in each Form 10-K (since the date of the
     distribution) and each recent Form 10-Q public filing made by each of ALZA
     and TDC with the Commission. Accordingly, the Purchase Option was present
     in the initial public distribution of the Class A Common Stock, was
     disseminated in TDC's charter documents, was discussed in ALZA's and TDC's
     periodic filings and was legended on each stock certificate for the Class A
     Common Stock. As a result, each TDC Class A Common stockholder received
     substantial notice as to the terms of the Purchase Option prior to making
     any investment decision with respect to the Class A Common Stock. In
     addition, recent public filings by both ALZA and TDC have indicated the
     status of funds available for product development and therefore when the
     potential exercise of the Purchase Option was likely to be triggered.
     During 1997, both parties have indicated that these funds would likely be
     exhausted during the third quarter of 1997.

     ALZA decided to exercise the Purchase Option at this time because TDC's 
Available Funds were exhausted in the third quarter of 1997 as anticipated, and 
TDC had no further funding available to expend on products and product 
development. Accordingly, ALZA exercised the Purchase Option in order to 
continue product development without interruption.

     ALZA decided to pay the exercise price to TDC Class A Common stockholders
in cash because ALZA had sufficient available cash, cash provides immediately
liquid proceeds at a readily determined value and a payment of cash would not be
dilutive to the value of existing ALZA stockholders. ALZA reasonably believes
the form of such payment to be fair to TDC Class A Common stockholders.

     The Restated Certificate does not require any approval of the stockholders
of TDC for the exercise of the Purchase Option.

     After making reasonable inquiry of management of TDC, ALZA believes that no
directors of TDC have retained an unaffiliated representative to act solely on
behalf of any security holders of TDC as no action is required by either 
TDC's directors or security holders to effect the Purchase Option.

     Reports
     -------

     Neither ALZA nor, to the best of ALZA's knowledge after reasonable inquiry
of management of TDC, TDC, has received any report, opinion (other than an
opinion of counsel) or
                                       5
<PAGE>
 
appraisal from an outside party which is materially related to the transaction
described herein.

                    BACKGROUND AND SUMMARY OF TRANSACTION
                    -------------------------------------

Identification of ALZA:

     This filing is being made by ALZA. Its principal business is
pharmaceutical research and development and the commercialization of
pharmaceutical products. The address of its principal executive offices are
950 Page Mill Road, Palo Alto, CA 94304.

     During the last five years, ALZA has not been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors).  During the
last five years, ALZA has not been a party to a civil proceeding of a judicial
or administrative body of competent jurisdiction and as a result of such
proceeding was or is subject to a judgment, decree or final order enjoining
further violations of, or prohibiting activities, subject to, federal or state
securities laws or finding any violation of such laws.


Identification and Securities of TDC:

     The issuer of the Class A Common Stock and the address of its principal
executive offices is:

                    Therapeutic Discovery Corporation
                    1454 Page Mill Road
                    Palo Alto, CA  94303-0806

     The exact title of the class of security which is the subject of this
filing is Class A Common Stock, par value $0.01, of TDC. The amount of Class A
Common Stock outstanding as of August 25, 1997, the most recent practicable
date, is 7,734,424. As of that date, there were also options to purchase 395,000
shares of Class A Common Stock immediately exercisable. The approximate number
of holders of record of such Class A Common Stock as of August 25, 1997, the
most recent practicable date, is 5,604.

     The principal market in which the Class A Common Stock is being traded is
the Nasdaq National Market.  The range of high and low bid quotations for the
Class A Common Stock for each quarterly period during the past two years is:

<TABLE>
<CAPTION>
        Period               High         Low
- -----------------------   ----------   ---------
<S>                       <C>          <C>
June 30, 1995                  7.875        6.00
September 30, 1995              7.75        6.75
December 31, 1995               7.25        6.75
March 31, 1996                10.625       7.125
June 30, 1996                  9.875       8.875
September 30, 1996             10.00        8.00
December 31, 1996             11.375       9.375
March 31, 1997                11.375       10.50
June 30, 1997                 11.375      10.625
</TABLE>

                                       6
<PAGE>
 
     To the best of ALZA's knowledge, after making reasonable inquiry, TDC has
not paid any dividends on the Class A Common Stock in the past two years.

     TDC is restricted from paying any dividends on the Class A Common Stock if,
after payment of such dividend, the amount of TDC's cash, cash equivalents and
short-term and long-term investments would be less than the Available Funds as
such term is defined in the Restated Certificate.


Past Contacts, Transactions or Negotiations:

     The nature and approximate amount in dollars of any transaction which has
occurred since the commencement of TDC's second full fiscal year preceding the
date of this Statement between ALZA and TDC are as follows:

              (i)   Since the commencement of TDC's second full fiscal year
                    preceding the date of this Statement, TDC paid approximately
                    $225,000,000 to ALZA pursuant to a Development Agreement
                    between ALZA and TDC dated March 10, 1993 whereby ALZA was
                    retained by TDC to undertake activities related to the 
                    selection and development of pharmaceutical products.

              (ii)  Since the commencement of TDC's second full fiscal year
                    preceding the date of this Statement, TDC paid approximately
                    $500,000 to ALZA pursuant to a Services Agreement 

                                       7
<PAGE>
 
                    between ALZA and TDC dated March 10, 1993 whereby ALZA was
                    retained by TDC to provide certain administrative services
                    to TDC (such as legal and accounting) in exchange for
                    payment of ALZA's costs in the provision of such services.

              (iii) There is also (a) a Technology License Agreement dated March
                    10, 1993 between ALZA and TDC, whereby ALZA licensed certain
                    proprietary technology to TDC, and (b) a License Option
                    Agreement dated March 10, 1993 between ALZA and TDC, whereby
                    TDC granted ALZA an option to license certain products from
                    TDC. No amounts have been paid by either of ALZA or TDC to
                    the other pursuant to such agreements since the commencement
                    of TDC's second full fiscal year preceding the date of this
                    Statement except as set forth in section (iv) below.

              (iv)  In January of 1997, ALZA exercised its option to license
                    from TDC for 12 European countries a second-generation
                    transdermal testosterone product to follow ALZA's existing
                    Testoderm(R) product. ALZA entered into an agreement with
                    Ferring N.V. to market the TDC product in such countries. As
                    a result of ALZA's exercise of this license and the
                    arrangement with Ferring, ALZA paid TDC $580,000, a portion
                    of the upfront payment ALZA received from Ferring, and will
                    receive payments from ALZA based on sales of the product in
                    the 12 European countries covered by ALZA's agreement with
                    Ferring.

              (v)   In February of 1997, ALZA exercised its option to license
                    from TDC a once-daily OROS(R) hydromorphone product on a
                    worldwide basis. ALZA entered into an agreement with Knoll
                    Pharmaceutical Company and Knoll A.G. (together "Knoll") for
                    the further clinical development and worldwide
                    commercialization of that product. As a result of ALZA's
                    exercise of the license, TDC will receive a portion of the
                    amounts ALZA receives from Knoll based on worldwide sales of
                    the product, and a portion of certain milestone payments
                    made by Knoll to ALZA.

                                       8
<PAGE>
 
Terms of the Transaction:

     ALZA exercised its option to purchase all of TDC's Class A Common Stock on
August 25, 1997 by delivering an exercise notice to TDC. The terms of the
Purchase Option are set forth in TDC's Restated Certificate. Pursuant to the
Restated Certificate, the exercise price of the Purchase Option is $100 million.
ALZA has determined that September 29, 1997 will be the Closing Date. ALZA will
deposit the exercise price with Boston EquiServe, L.P., as Payment Agent, on or
prior to that date. Promptly following the Closing Date, and upon receipt of
stock certificates for the Class A Common Stock as instructed by the Payment
Agent, the Payment Agent will distribute the exercise price pro rata to each
person or entity who was a holder of Class A Common Stock at the close of
business on the Closing Date. In the case of any person or entity holding Class
A Common Stock in a brokerage account, the broker will credit the relevant
account with such amount.

     In accordance with the terms of the Restated Certificate, the stockholders
of the Class A Common Stock do not need to take any steps to approve the
purchase.  Title to the Class A Common Stock will automatically vest in ALZA on
the Closing Date and the exercise price will be paid to such stockholders, upon
tender of their stock certificates directly or through their brokers, in
accordance with their respective interests.

Plans or Proposals of ALZA:

     Subsequent to the purchase of the Class A Common Stock by ALZA, TDC will be
a wholly-owned subsidiary of ALZA. ALZA anticipates de-listing TDC from the
Nasdaq National Market and suspending its reporting requirements with the
Securities and Exchange Commission by filing a Form 15. ALZA intends to replace
TDC's officers and Board of Directors with ALZA employees.

Interest in Securities of TDC:

     As of August 25, 1997, no shares of Class A Common Stock of TDC are
beneficially owned by ALZA, by any pension, profit sharing or similar plan of
ALZA or, to ALZA's knowledge after reasonable inquiry of management of TDC, by
TDC, by each executive officer and director of either ALZA, TDC, any person
controlling either ALZA or TDC or any executive officer of any corporation
ultimately in control of either ALZA or TDC, or by any associate or majority
owned subsidiary of either ALZA or TDC except as set out on the following table:

                                       9
<PAGE>
 
<TABLE>
<CAPTION>
                                                                                                     Immediately
                                                                     Direct         Indirect         Exercisable
Name                            Position                           Ownership       Ownership           Options
- ----                            --------                           ---------       ---------         -----------
<S>                              <C>                             <C>             <C>                 <C>
Blaschke, Dr. Terrence F.        Director of TDC                         4,500           6,200           40,000
 
Cozadd, Bruce C.                 Senior Vice President and                  15
                                 Chief Financial Officer of ALZA
 
Fethe, Harold                    Vice President, Human                                   3,304
                                 Resources of ALZA
 
Fulscher, Dr. Gary V.            Senior Vice President,                  4,489           4,693
                                 Operations of ALZA
 
Hoffmann, David R.               Vice President, Finance and             1,622           6,223
                                 Secretary of TDC

Lairson, Dr. Paul D.             Director of TDC                                                         40,000
 
Martin, Suzanne G.               Vice President, Research and              695
                                 Development Administration of TDC
 
Neil, Gary L., Ph.D.             Director, President and Chief                          12,000          160,000
                                 Executive Officer of TDC
 
Phipps, Allen M.                 Chairman of the Board of TDC           10,000                           60,000
 
Sommers, William P, Ph.D.        Director of TDC                                         2,919           40,000
 
Stern, Julian N.                 Director and Secretary of ALZA          9,393
 
Theeuwes, Dr. Felix              President, New Ventures and               413          17,064
                                 Chief Scientist of ALZA
 
Zaffaroni, Dr. Alejandro         Co-Chairman of the Board and           95,594
                                 Founder of ALZA
</TABLE>

As of December 31, 1996 ALZA's 401(k) tax deferral investment plan owned 18,902
shares of Class A Common Stock for the accounts of certain ALZA employees. The 
employees direct the investment of these accounts. Some of the shares reported 
as indirectly owned by ALZA employees in the table above are included in the 
foregoing amount.

                                       10
<PAGE>
 
CONTRACTS, ARRANGEMENTS OR UNDERSTANDINGS WITH RESPECT TO TDC'S CLASS A COMMON
STOCK:

     Article FIFTH of the Restated Certificate provides ALZA with the Purchase
Option. The Purchase Option provides that ALZA may purchase all, but not less
than all, of the issued and outstanding Class A Common Stock at any time prior
to the earlier of: (i) 60 days after the later of (a) the date of filing with
the Commission or (b) the due date of TDC's Form 10-K or Form 10-Q containing a
balance sheet showing that TDC has less than an aggregate of $5 million in cash,
cash equivalents, and short-term and long-term investments, or (ii) June 30,
1999. ALZA may exercise the Purchase Option at any time prior to such expiration
date by mailing an exercise notice to TDC. This exercise notice must identify
certain information, including a Closing Date for the purchase and the exercise
price and form of consideration to be paid to TDC stockholders. The Closing Date
must be within 90 days of the exercise date but may be extended by ALZA in
certain circumstances outlined in the Restated Certificate, such as the need for
regulatory clearance. ALZA exercised the Purchase Option by providing the
foregoing exercise notice to TDC on August 25, 1997. The Closing Date has been
set for September 29, 1997.

     From the date of exercise of the Purchase Option until the Closing Date,
TDC is prohibited by the terms of the Restated Certificate from engaging in any
extraordinary corporate activity without the prior written consent of ALZA.

     Article FOURTH of the Restated Certificate provides that as soon as ALZA
exercises the Purchase Option, TDC's board shall cease to be classified, the
number of authorized TDC directors shall be increased in accordance with a
formula set forth in the Restated Certificate and the holders of TDC's Class B
Common Stock (currently ALZA) shall have the sole right to appoint the directors
thereafter.

     Within 15 days after the mailing of the exercise notice to TDC, TDC must
provide ALZA with a status statement containing certain financial information.
This financial information includes all actual and contingent liabilities of
TDC. ALZA then may reduce the exercise price by the amount of such liabilities. 
It is not anticipated that any reduction will occur in the current circumstances
of this transaction.

     ALZA must designate a Payment Agent who will distribute the exercise price
to the TDC stockholders. ALZA must also deposit both the exercise price, and
irrevocable instructions to pay the exercise price to TDC stockholders of record
as of the close of business on the Closing Date, with the Payment Agent on or
prior to the Closing Date.

                                       11
<PAGE>
 
     On the Closing Date, title to the Class A Common Stock will automatically
transfer to and vest in ALZA without further act of any person. The Payment
Agent will then disburse the exercise price to TDC stockholders upon tender of 
stock certificates to the Payment Agent as instructed thereby.

                      OTHER PROVISIONS OF THE TRANSACTION
                      -----------------------------------

     Appraisal rights are not afforded under either applicable law or the
Restated Certificate to TDC stockholders in respect of the exercise of the
Purchase Option and none will be afforded by either ALZA or TDC.  ALZA is not
aware of any rights available to objecting holders of Class A Common Stock under
applicable law.

     ALZA is unaware, after making reasonable inquiry of TDC, of any grant of
access to unaffiliated security holders to the corporate files of either TDC or
ALZA or the appointment of counsel or appraisal services for unaffiliated
security holders at the expense of either TDC or ALZA.

                        SUMMARY OF FINANCIAL STATEMENTS
                        -------------------------------

Selected Consolidated Financial Data

Set forth below is a summary of TDC's selected consolidated financial data,
which has been excerpted or derived from the information contained in TDC's
Annual Reports on Form 10-K for the years ended December 31, 1996 and 1995, and
its Quarterly Report on Form 10-Q for the quarterly period ended June 30, 1997. 
More comprehensive information is included in such reports and other
documents filed by TDC with the Commission, and the following information should
be read in conjunction with such reports and other documents and the financial
information (including any related notes and Management's Discussion and
Analysis of Financial Condition and Results of Operations) contained therein.

Statement of Income Data:
(in millions, except per share amounts)

<TABLE> 
<CAPTION> 
                                   Year ended December 31,       Six Months ended June 30,
                                     1996          1995            1997             1996
                                   -------------------------------------------------------
<S>                                <C>           <C>             <C>             <C> 
Total revenues                     $   8.2       $ 11.5          $  1.5          $  4.7
Net loss                           $  94.8       $ 59.4          $ 48.3          $ 46.5 
Loss per share                     $ 12.25       $ 7.68          $ 6.24          $ 6.01  
Ratio of earnings
 to fixed changes                      N/A          N/A             N/A             N/A
</TABLE> 

<TABLE> 
<CAPTION> 
Balance Sheet Data:
(in millions, except per share amounts)

                               December 31, 1996                  June 30, 1997                 
                               -----------------                  -------------                 
<S>                            <C>                                <C>                           
Working capital                    $67.9                             $20.9                      
Total assets                        88.5                              40.5                      
Total stockholders'                                                                      
 equity                             69.1                              21.8                      
Book value per share               $8.94                             $2.82                      
</TABLE> 

Note to Selected Consolidated Financial Data:

(1) TDC had no material fixed charges for the periods presented.

                                  CONCLUSION
                                  ----------

     If you have any questions with respect to this transaction, please contact
ALZA Corporate and Investor Relations at (650) 494-5222.

     ALZA and TDC wish to thank you for your investment and interest in TDC.  We
sincerely hope that you are pleased with your return on this investment.

                                       12


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