ALZA CORP
SC 13D/A, 1997-09-30
PHARMACEUTICAL PREPARATIONS
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- --------------------------------------------------------------------------------
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
 
                       --------------------------------

                                 SCHEDULE 13D

                   Under the Securities Exchange Act of 1934

                               (Amendment No. 2)

                       Therapeutic Discovery Corporation
                       ---------------------------------
                               (Name of Issuer)

                     Class A Common Stock, Par Value $0.01
                     -------------------------------------
                        (Title of Class of Securities)

                                   883376105
                                   ---------
                                 CUSIP Number


                             Peter D. Staple, Esq.
                               ALZA Corporation
                              950 Page Mill Road
                          Palo Alto, California 94303
                                (650) 494-5000

                                With a copy to:
                             Sarah A. O'Dowd, Esq.
                       Heller, Ehrman, White & McAuliffe
                             525 University Avenue
                          Palo Alto, California 94301
                                (650) 324-7000
                                
            ------------------------------------------------------
                      (Name, address and telephone number
                        of person authorized to receive
                          notices and communications)

                                September 29, 1997
                                        
                ----------------------------------------------
                         (Date of Event which requires
                           filing of this statement)
<PAGE>
 
     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box: [_]

                                       2
<PAGE>
 
CUSIP No. 883376105

1)    Name of Reporting Persons:
      S.S. or I.R.S Identification No. of above person
                     ALZA Corporation
                     I.R.S. Identification No. 77-0142070
- --------------------------------------------------------------------------------

2)    Check the Appropriate Box if a Member of a Group

      (a)  [_]
              ------------------------------------------------------------------

      (b)  [_]
              ------------------------------------------------------------------

- --------------------------------------------------------------------------------
 
3)    SEC Use Only
                  --------------------------------------------------------------
 
- --------------------------------------------------------------------------------

4)    Source of Funds:  00
 
- --------------------------------------------------------------------------------

5)    [_]  Check if Disclosure of Legal Proceedings is Required
           Pursuant to Items 2(d) or 2(e)

- --------------------------------------------------------------------------------

6)    Citizenship or Place of Organization:  Delaware

- --------------------------------------------------------------------------------
 
                  7)   Sole Voting Power
                          7,734,424 Shares of Class A Common Stock and 100
                          Shares of Class B Common Stock
                     -----------------------------------------------------------

Number of Shares  8)   Shared Voting Power
  Beneficially            None
 Owned by Each       -----------------------------------------------------------
Reporting Person 
      With        9)   Sole Dispositive Power
                         7,734,424 Shares of Class A Common Stock and 100 Shares
                         of Class B Common Stock
                     -----------------------------------------------------------

                  10)  Shared Dispositive Power
                         None
                     -----------------------------------------------------------

11)   Aggregate Amount Beneficially Owned by Each Reporting Person:  7,734,424
      Shares of Class A Common Stock and 100 Shares of Class B Common Stock

- --------------------------------------------------------------------------------
 
12)   [_]  Check if the Aggregate Amount in Row (11)
           Excludes Certain Shares

- --------------------------------------------------------------------------------

13)   Percent of Class Represented by amount in Row (11):
                                 100.0% (See response to Item 3)
- --------------------------------------------------------------------------------

14)    Type of Reporting Person
                                 CO
- --------------------------------------------------------------------------------
<PAGE>
 
Item 1.  Security and Issuer.
         ------------------- 

     This statement constitutes Amendment No. 2 to the Statement on Schedule
13D, dated June 22, 1993, relating to shares of Class A Common Stock, $.01 par
value per share (the "Class A Common Stock") of Therapeutic Discovery
Corporation, a Delaware corporation ("TDC"). 

     The reporting person, ALZA Corporation, a Delaware corporation, ("ALZA") is
filing this Amendment No. 2 on Schedule 13D because, on September 29, 1997 it
concluded the exercise of its option to purchase all of the issued and
outstanding Class A Common Stock of TDC. As a consequence, ALZA now owns all
issued and outstanding stock of TDC and TDC is a wholly owned subsidiary of
ALZA.


                                       3
<PAGE>
 
 
Item 5.  Interest in Securities of the Issuer.
         ------------------------------------

     As of September 29, 1997, ALZA owns 7,734,424 shares of Class A Common 
Stock and 100 shares of Class B Common Stock of TDC. ALZA owns 100% of the 
issued and outstanding stock of TDC.


                                       4
<PAGE>
 
Item 7.  Exhibits.
         --------

         None.
                                   SIGNATURE

       After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

September 30, 1997                ALZA CORPORATION


                                   By: /s/ PETER D. STAPLE
                                      -------------------------------
                                      Peter D. Staple
                                      Senior Vice President and
                                      General Counsel


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