ALZA CORP
SC 13D/A, 1999-07-20
PHARMACEUTICAL PREPARATIONS
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                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C.  20549

                              ----------------


                                SCHEDULE 13D

                               (Rule 13d-101)

   INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a) AND
                AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a)

                             (Amendment No. 4)*



                                 Alkermes, Inc.
                                 --------------
                                (Name of Issuer)

                                  Common Stock
                                  ------------
                         (Title of Class of Securities)

                                   01642T108
                                   ---------
                                  CUSIP Number

                             Peter D. Staple, Esq.
                                ALZA Corporation
                               950 Page Mill Road
                          Palo Alto, California 94303
                                 (650) 494-5000

          -----------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                July 15, 1999
          -----------------------------------------------------------
            (Date of Event which requires Filing of this statement)

     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box:[_].

     Note.  Six copies of this statement, including all exhibits, should be
filed with the Commission.  See Rule 13d-1 (a) for other parties to whom copies
are to be sent.

                       (Continued on following pages)
                             (Page 1 of 4 pages)


- -------------
*  The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.

   The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
<PAGE>

- -----------------------                                  ---------------------
  CUSIP NO. 01642T108                   13D                PAGE 2 OF 4 PAGES
- -----------------------                                  ---------------------

- ------------------------------------------------------------------------------
      NAME OF REPORTING PERSONS
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

      ALZA Corporation
      I.R.S. Identification No. 77-0142070

- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
 2                                                              (a) [_]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      SOURCE OF FUNDS*
 4
      00

- ------------------------------------------------------------------------------
      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
 5    PURSUANT TO ITEM 2(d) or 2(e)                                 [_]


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 6
      Delaware

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     7
     NUMBER OF            1,360,000 shares of Common Stock

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      8
                          0
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     9
    REPORTING             1,360,000 share of Common Stock

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          10

- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
11
      1,360,000 shares of Common Stock

- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
12                                                                  [_]


- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
13
      5.4%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
14
      CO

- ------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!


                              Page 2 of 4 pages
<PAGE>

Item 5.  Interest in Securities of the Issuer.
         ------------------------------------

         (a)  As of July 15, 1999, ALZA held 1,360,000 shares of Common Stock
of Alkermes, equal to approximately 5.4% of the total number of issued and
outstanding shares of Common Stock of Alkermes.

         (b)  Sole voting power - 1,360,000 shares of Common Stock Shared
              voting power - 0
              Sole dispositive power - 1,360,000 shares of Common Stock
              Shared dispositive power - 0

         (c)  Since the filing of Amendment No. 3 to this Schedule 13D of June
11, 1999, ALZA has sold 390,000 shares of Common Stock of Alkermes in several
open market transactions each at a price of $26 per share.

         (d)  Not applicable.

         (e)  Not applicable.


                              Page 3 of 4 Pages
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                                  SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


July 19, 1999                           ALZA CORPORATION



                                        By: /s/ Peter D. Staple
                                           ------------------------------
                                           Peter D. Staple,
                                           Senior Vice President and
                                           General Counsel

                              Page 4 of 4 Pages


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