ALZA CORP
SC 13G/A, 2000-02-11
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*


                                Alza Corporation
                                ----------------
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                   022615 10 8
                                   -----------
                                 (CUSIP Number)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                     [ ]   Rule 13d-1(b)
                     [x]   Rule 13d-1(c)
                     [ ]   Rule 13d-1(d)



*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



<PAGE>
<TABLE>
<CAPTION>
                                                                                                             13G
CUSIP NO.  022615 10 8

- -------------- --------------------------------------------------------------------------------------------------------------------
<S>            <C>
      1        NAME OF REPORTING PERSON
               I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               ISP Opco Holdings Inc.
- -------------- --------------------------------------------------------------------------------------------------------------------
      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                              (a) [ ]
                                                                                                             (b) [x]
- -------------- --------------------------------------------------------------------------------------------------------------------
      3        SEC USE ONLY

- -------------- --------------------------------------------------------------------------------------------------------------------
      4        CITIZENSHIP OR PLACE OF ORGANIZATION
                                    Delaware
- ------------------------------ ------------ ---------------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
          NUMBER OF
           SHARES                                     0
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                               ------------ ---------------------------------------------------------------------------------------
                                    6       SHARED VOTING POWER
                                                                         151,010
                               ------------ ---------------------------------------------------------------------------------------
                                    7       SOLE DISPOSITIVE POWER

                                                                               0
                               ------------ ---------------------------------------------------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
                                                                         151,010
- -------------- --------------------------------------------------------------------------------------------------------------------
      9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                                                         151,010
- -------------- --------------------------------------------------------------------------------------------------------------------
     10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 [  ]
- -------------- --------------------------------------------------------------------------------------------------------------------
     11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                                                            0.1%
- -------------- --------------------------------------------------------------------------------------------------------------------
     12        TYPE OF REPORTING PERSON

                                                                              CO
- -------------- --------------------------------------------------------------------------------------------------------------------



                                  Page 2 of 10

<PAGE>
                                                                                                            13G
CUSIP NO.  022615 10 8

- -------------- --------------------------------------------------------------------------------------------------------------------
      1        NAME OF REPORTING PERSON
               I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               ISP Investments Inc.
- -------------- --------------------------------------------------------------------------------------------------------------------
      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                              (a) [ ]
                                                                                                             (b) [x]
- -------------- --------------------------------------------------------------------------------------------------------------------
      3        SEC USE ONLY

- -------------- --------------------------------------------------------------------------------------------------------------------
      4        CITIZENSHIP OR PLACE OF ORGANIZATION
                                    Delaware
- ------------------------------ ------------ ---------------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
          NUMBER OF
           SHARES                                     151,010
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                               ------------ ---------------------------------------------------------------------------------------
                                    6       SHARED VOTING POWER
                                                                               0
                               ------------ ---------------------------------------------------------------------------------------
                                    7       SOLE DISPOSITIVE POWER

                                                                         151,010
                               ------------ ---------------------------------------------------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
                                                                               0
- -------------- --------------------------------------------------------------------------------------------------------------------
      9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                                                         151,010
- -------------- --------------------------------------------------------------------------------------------------------------------
     10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 [  ]
- -------------- --------------------------------------------------------------------------------------------------------------------
     11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                                                            0.1%
- -------------- --------------------------------------------------------------------------------------------------------------------
     12        TYPE OF REPORTING PERSON

                                                                              CO
- -------------- --------------------------------------------------------------------------------------------------------------------



                                  Page 3 of 10
<PAGE>
                                                                                                            13G
CUSIP NO.  022615 10 8

- -------------- --------------------------------------------------------------------------------------------------------------------
      1        NAME OF REPORTING PERSON
               I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               International Specialty Products Inc.
- -------------- --------------------------------------------------------------------------------------------------------------------
      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                              (a) [ ]
                                                                                                             (b) [x]
- -------------- --------------------------------------------------------------------------------------------------------------------
      3        SEC USE ONLY

- -------------- --------------------------------------------------------------------------------------------------------------------
      4        CITIZENSHIP OR PLACE OF ORGANIZATION
                                    Delaware
- ------------------------------ ------------ ---------------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
          NUMBER OF
           SHARES                                     66,215
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                               ------------ ---------------------------------------------------------------------------------------
                                    6       SHARED VOTING POWER
                                                                         151,010
                               ------------ ---------------------------------------------------------------------------------------
                                    7       SOLE DISPOSITIVE POWER

                                                                          66,215
                               ------------ ---------------------------------------------------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
                                                                         151,010
- -------------- --------------------------------------------------------------------------------------------------------------------
      9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                                                         217,225
- -------------- --------------------------------------------------------------------------------------------------------------------
     10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 [  ]
- -------------- --------------------------------------------------------------------------------------------------------------------
     11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                                                           0.2%
- -------------- --------------------------------------------------------------------------------------------------------------------
     12        TYPE OF REPORTING PERSON

                                                                              CO
- -------------- --------------------------------------------------------------------------------------------------------------------



                                  Page 4 of 10
<PAGE>
                                                                                                            13G
CUSIP NO.  022615 10 8

- -------------- --------------------------------------------------------------------------------------------------------------------
      1        NAME OF REPORTING PERSON
               I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Samuel J. Heyman
- -------------- --------------------------------------------------------------------------------------------------------------------
      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                              (a) [ ]
                                                                                                             (b) [x]
- -------------- --------------------------------------------------------------------------------------------------------------------
      3        SEC USE ONLY

- -------------- --------------------------------------------------------------------------------------------------------------------
      4        CITIZENSHIP OR PLACE OF ORGANIZATION
               USA
- ------------------------------ ------------ ---------------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
          NUMBER OF
           SHARES                                     0
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                               ------------ ---------------------------------------------------------------------------------------
                                    6       SHARED VOTING POWER
                                                                       2,566,935
                               ------------ ---------------------------------------------------------------------------------------
                                    7       SOLE DISPOSITIVE POWER

                                                                               0
                               ------------ ---------------------------------------------------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
                                                                       2,566,935
- -------------- --------------------------------------------------------------------------------------------------------------------
      9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                                                       2,566,935
- -------------- --------------------------------------------------------------------------------------------------------------------
     10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 [  ]
- -------------- --------------------------------------------------------------------------------------------------------------------
     11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                                                            2.5%
- -------------- --------------------------------------------------------------------------------------------------------------------
     12        TYPE OF REPORTING PERSON

                                                                              IN
- -------------- --------------------------------------------------------------------------------------------------------------------



                                  Page 5 of 10
<PAGE>
                                                                                                             13G
CUSIP NO.  022615 10 8

- -------------- --------------------------------------------------------------------------------------------------------------------
      1        NAME OF REPORTING PERSON
               I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

               Heyman Investment Associates Limited Partnership
- -------------- --------------------------------------------------------------------------------------------------------------------
      2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                              (a) [ ]
                                                                                                             (b) [x]
- -------------- --------------------------------------------------------------------------------------------------------------------
      3        SEC USE ONLY

- -------------- --------------------------------------------------------------------------------------------------------------------
      4        CITIZENSHIP OR PLACE OF ORGANIZATION
                                   Connecticut
- ------------------------------ ------------ ---------------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
          NUMBER OF
           SHARES                                     2,349,710
        BENEFICIALLY
          OWNED BY
            EACH
          REPORTING
           PERSON
            WITH
                               ------------ ---------------------------------------------------------------------------------------
                                    6       SHARED VOTING POWER
                                                                               0
                               ------------ ---------------------------------------------------------------------------------------
                                    7       SOLE DISPOSITIVE POWER

                                                                       2,349,710
                               ------------ ---------------------------------------------------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
                                                                               0
- -------------- --------------------------------------------------------------------------------------------------------------------
      9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                                                       2,349,710
- -------------- --------------------------------------------------------------------------------------------------------------------
     10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 [  ]
- -------------- --------------------------------------------------------------------------------------------------------------------
     11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                                                            2.3%
- -------------- --------------------------------------------------------------------------------------------------------------------
     12        TYPE OF REPORTING PERSON

                                                                              PN
- -------------- --------------------------------------------------------------------------------------------------------------------

</TABLE>

                                  Page 6 of 10
<PAGE>
ITEM 1.  NAME OF ISSUER AND ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

(a)  Name of Issuer:
                                Alza Corporation

(b)  Address of Issuer's Principal Executive Offices:
           950 Page Mill Road
           PO Box 10950
           Palo Alto, CA  94303-0802


ITEM 2.

           (a)       Name of Person Filing:

                     (i)       ISP Opco Holdings Inc.
                     (ii)      ISP Investments Inc.
                     (iii)     International Specialty Products Inc.
                     (iv)      Samuel J. Heyman
                     (v)       Heyman Investment Associates Limited Partnership


            (b)     Address of Principal Business Office or, if None, Residence:

                     The principal business office of each of the filing persons
listed in Item 2(a) is as follows:

                     The principal business office of ISP Opco Holdings Inc.,
ISP Investments Inc. and International Specialty Products Inc. is 300 Delaware
Avenue, Wilmington, Delaware 19801.

                     The principal business office of Samuel J. Heyman is 1361
Alps Road, Wayne, New Jersey 07470.

                     The principal business office of Heyman Investment
Associates Limited Partnership is 333 Post Road West, Westport, Connecticut
06881.

           (c), (d) and (e) For information with respect to citizenship of each
of the filing persons, title of class of securities and CUSIP number for the
shares held by such persons, see the appropriate cover page above.

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.SS. 240.13D-1(B), OR 240.
        13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

             (a)  [  ]     Broker or dealer registered under section 15 of the
                           Act (15 U.S.C. 78o)

             (b)  [  ]     Bank as defined in section 3(a)(6) of the Act (15
                           U.S.C. 78c)

             (c)  [  ]     Insurance company as defined in section 3(a)(19) of
                           the Act (15 U.S.C. 78c)

             (d)  [  ]     Investment company registered under section 8 of the
                           Investment Company Act of 1940 (15 U.S.C. 80a-8)

             (e)  [  ]     An investment adviser in accordance with ss.
                           240.13d-1(b) (1) (ii) (E)

             (f)  [  ]     An employee benefit plan or endowment fund in
                           accordance with ss. 240.13d-1(b)(1)(ii)(F)

             (g)  [  ]     A parent holding company or control person in
                           accordance with ss. 240.13d-1(b)(1)(ii)(G)

             (h)  [  ]     A savings association as defined in Section 3 (b) of
                           the Federal Deposit Insurance Act (12 U.S.C. 1813)


                                  Page 7 of 10
<PAGE>
             (i)  [  ]     A church plan that is excluded from the definition of
                           an investment company under section 3(c) (14) of the
                           Investment Company Act of 1940 (15 U.S.C. 80a-3)

             (j)  [  ]     Group, in accordance with ss. 240.13d-1(b) (1) (ii)
                           (J).


ITEM 4. OWNERSHIP.

                     For information concerning the (a) number of shares
beneficially owned by each filing person as of December 31, 1999; (b) percent of
class of shares such number represents; (c) number of shares to which such
person has as of December 31, 1999 (i) sole voting power, (ii) shared voting
power, (iii) sole dispositive power and (iv) shared dispositive power, see the
appropriate cover page above.

                     In addition to the shares reported in its cover page above,
as of December 31, 1999, Heyman Investment Associates Limited Partnership was a
party to equity derivative contracts with a broker-dealer relating to an
aggregate of 2,025,865 shares of common stock of the Issuer.

ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

      If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following [X].

ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

      ISP Investments Inc. has granted to a trust the right to receive dividends
from, and the right to receive the proceeds from the sale of, 42,400 shares of
common stock of the Issuer beneficially owned by ISP Investments Inc. as of
December 31, 1999.

ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
        SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

      See Schedule A hereto.

ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

      Not Applicable

ITEM 9. NOTICE OF DISSOLUTION OF GROUP.

      Not Applicable

ITEM 10. CERTIFICATION.

      By signing below, each of the undersigned certifies that, to the best of
his or its knowledge and belief, the securities referred to above were not
acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.


                                  Page 8 of 10
<PAGE>
                                    SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.


Dated: February 11, 2000


ISP Opco Holdings Inc.
ISP Investments Inc.
International Specialty Products Inc.

By: /s/ Susan B. Yoss
    -----------------------------------------
    Susan B. Yoss
    Senior Vice President and Treasurer




/s/ Samuel J. Heyman
- ---------------------------------------------
Samuel J. Heyman




Heyman Investment Associates Limited Partnership

By: /s/ James R. Mazzeo
    -----------------------------------------
    James R. Mazzeo
    Treasurer






                                  Page 9 of 10
<PAGE>
                                   SCHEDULE A



      International Specialty Products Inc. owns 100% of the outstanding common
stock of ISP Opco Holdings Inc. which, in turn, owns 100% of the outstanding
common stock of ISP Investments Inc.





















                                  Page 10 of 10


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