ALZA CORP
S-3, EX-25.1, 2000-09-25
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                                                    EXHIBIT 25.1

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                            _______________________

                                   FORM T-1

             Statement of Eligibility and Qualification Under the
                 Trust Indenture Act of 1939 of a Corporation
                         Designated to Act as Trustee
                            _______________________

   CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO
                             SECTION 305(B)(2)____
                            _______________________

                    CHASE MANHATTAN BANK AND TRUST COMPANY,
                             NATIONAL ASSOCIATION
              (Exact name of trustee as specified in its charter)


                                  95-4655078
                     (I.R.S. Employer Identification No.)


         101 California Street, Suite #2725, San Francisco, California
                   (Address of principal executive offices)

                                     94111
                                  (Zip Code)
                              __________________

                               ALZA Corporation
              (Exact name of Obligor as specified in its charter)

                                   Delaware
        (State or other jurisdiction of incorporation or organization)

                                  77-0142070
                     (I.R.S. Employer Identification No.)

                              950 Page Mill Road
                                P. O. Box 10950
                             Palo Alto, California
                   (Address of principal executive offices)

                                  94303-0802
                                  (Zip Code)


                            _______________________

              0.00% Convertible Subordinated Debentures due 2020
                        (Title of Indenture securities)

                                       1
<PAGE>

Item 1.   General Information.

          Furnish the following information as to the trustee:

     (a)  Name and address of each examining or supervising authority to which
          it is subject.

          Comptroller of the Currency, Washington, D.C.
          Board of Governors of the Federal Reserve System, Washington, D.C.

     (b)  Whether it is authorized to exercise corporate trust powers.

          Yes.

Item 2.   Affiliations with Obligor.

     If the Obligor is an affiliate of the trustee, describe each such
     affiliation.

     None.

Item 4.   Trusteeships under Other Indentures

     (a)  Title of securities outstanding under each such indenture.
          Liquid Yield Option Notes due 2014 issued under Indenture dated as of
          July 1, 1994.


Item 16.  List of Exhibits.

     List below all exhibits filed as part of this statement of eligibility.

     Exhibit 1.  Articles of Association of the Trustee as Now in Effect (see
                 Exhibit 1 to Form T-1 filed in connection with Registration
                 Statement No. 333-41329, which is incorporated by reference).

     Exhibit 2.  Certificate of Authority of the Trustee to Commence Business
                 (see Exhibit 2 to Form T-1 filed in connection with
                 Registration Statement No. 333-41329, which is incorporated by
                 reference).

     Exhibit 3.  Authorization of the Trustee to Exercise Corporate Trust Powers
                 (contained in Exhibit 2).

     Exhibit 4.  Existing By-Laws of the Trustee (see Exhibit 4 to Form T-1
                 filed in connection with Registration Statement No. 333-41329,
                 which is incorporated by reference).

     Exhibit 5.  Not Applicable

     Exhibit 6.  The consent of the Trustee required by Section 321 (b) of the
                 Act (see Exhibit 6 to Form T-1 filed in connection with
                 Registration Statement No. 333-41329, which is incorporated by
                 reference).

     Exhibit 7.  A copy of the latest report of condition of the Trustee,
                 published pursuant to law or the requirements of its
                 supervising or examining authority.

                                       2
<PAGE>

     Exhibit 8.  Not Applicable

     Exhibit 9.  Not Applicable

                                       3
<PAGE>

                                   SIGNATURE

     Pursuant to the requirements of the Trust Indenture Act of 1939, the
Trustee, Chase Manhattan Bank and Trust Company, National Association, has duly
caused this statement of eligibility and qualification to be signed on its
behalf by the undersigned, thereunto duly authorized, all in the City of San
Francisco, and State of California, on the 22nd day of September 2000.

                                 CHASE MANHATTAN BANK AND TRUST
                                 COMPANY, NATIONAL ASSOCIATION


                                 By  /s/ Hans H. Helley
                                    -----------------------
                                     Hans H. Helley
                                     Vice President

                                       4
<PAGE>

Exhibit 7.  Report of Condition of the Trustee.
================================================================================

Consolidated Report of Condition of Chase Manhattan Bank and Trust Company, N.A.
                                    --------------------------------------------
                                               (Legal Title)

Located at  1800  Century Park East, Ste. 400   Los Angeles,   CA        94111
            --------------------------------------------------------------------
                (Street)                              (City)   (State)   (Zip)

as of close of business on   June 30, 2000
                           --------------------

================================================================================
================================================================================
ASSETS DOLLAR AMOUNTS IN THOUSANDS

<TABLE>
<CAPTION>
<S>     <C>                                                                      <C>
1.      Cash and balances due from
          a. Noninterest-bearing balances and currency and coin (1,2)             3,264
          b. Interest bearing balances (3)                                            0
2.      Securities
          a. Held-to-maturity securities (from Schedule RC-B, column A)               0
          b. Available-for-sale securities (from Schedule RC-B, column D)         1,093
3.      Federal Funds sold (4) and securities purchased agreements to resell     54,750
4.      Loans and lease financing receivables:
          a. Loans and leases, net of unearned income (from Schedule RC-C)          143
          b. LESS: Allowance for loan and lease losses                                0
          c. LESS: Allocated transfer risk reserve                                    0
          d. Loans and leases, net of unearned income, allowance, and
               reserve (item 4.a minus 4.b and 4.c)                                 143
5.      Trading assets                                                                0
6.      Premises and fixed  assets (including capitalized leases)                   132
7.      Other real estate owned (from Schedule RC-M)                                  0
8.      Investments in unconsolidated subsidiaries and associated companies
        (from Schedule RC-M)                                                          0
9.      Customers liability to this bank on acceptances outstanding                   0
10.     Intangible assets (from Schedule RC-M)                                      848
11.     Other assets (from Schedule RC-F)                                         2,004
12a.           TOTAL ASSETS                                                      62,234
</TABLE>

(1)  includes cash items in process of collection and unposted debits.
(2)  The amount reported in this item must be greater than or equal to the sum
     of Schedule RC-M, items 3.a and 3.b
(3)  includes time certificates of deposit not held for trading.
(4)  Report "term federal funds sold" in Schedule RC, item 4.a "Loans and
     leases, net of unearned income" and in Schedule RC-C, part 1.

                                       5
<PAGE>

LIABILITIES

13.  Deposits:
         a. In domestic offices (sum of totals of columns A and C from
              Schedule RC-E)                                             29,559
              (1) Noninterest-bearing                                     9,969
              (2) Interest-bearing                                       19,590
         b. In foreign offices, Edge and Agreement subsidiaries, and IBF'
              (1) Noninterest-bearing
              (2) Interest-bearing
14.  Federal funds purchased (2) and securities sold under agreements to
     repurchase                                                               0
15.  a. Demand notes issued to the U.S. Treasury                              0
     b. Trading liabilities                                                   0
16.  Other borrowed money (includes mortgage indebtedness and
     obligations under capitalized leases):
     a. With a remaining maturity of one year or less                         0
     b. With a remaining maturity of more than one year through               0
     three years
     c. With a remaining maturity of more than three years                    0
17.  Not applicable
18.  Bank's liability on acceptances executed and outstanding                 0
19.  Subordinated notes and Debentures (3)                                    0
20.  Other liabilities (from Schedule RC-G)                               5,460
21.  Total liabilities (sum of items 13 through 20)                      35,019
22.  Not applicable

EQUITY CAPITAL

23.  Perpetual preferred stock and related surplus                            0
24.  Common stock--                                                         600
25.  Surplus (exclude all surplus related to preferred stock)            12,590
26.  a. Undivided profits and capital reserves                           14,025
     b. Net unrealized holding gains (losses) on available-for-sale           0
     securities
27.  Cumulative foreign currency translation adjustments
28.  a. Total equity capital (sum of items 23 through 27)                27,215
29.  Total liabilities, equity capital, and losses deferred
     pursuant to 12 U.S.C. 1823 (j) (sum of items 21 and 28.c)           62,234

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