IDS INVESTMENT SERIES INC
24F-2NT, 1995-11-24
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November 24, 1995


Securities and Exchange Commission
Attention:  Document Control - EDGAR
450 Fifth Street, N.W.
Washington, D.C. 20549-1004

Re:  Rule 24f-2 Notice for
     IDS Investment Series, Inc.
     SEC File No. 2-11328/811-54

Commissioners:

[i]  In accordance with the provisions of Rule 24f-2, IDS
     Investment Series, Inc. hereby files its Rule 24f-2 Notice for
     the fiscal year ended September 30, 1995 ("Fiscal Year").

[ii] Amount of securities registered other than under
     24f-2 which were unsold at the beginning of the
     fiscal year.*                                             $0   
  
[iii] Amount of securities registered during the fiscal
      year other than under 24f-2**                            $0

[iv] Amount of securities sold during the fiscal
     year***                                         $135,515,114 

[v]  Amount of securities sold pursuant to 24f-2     $135,515,114

[vi] Fee      $135,515,114  x  0.0002900              $ 46,729.35

Enclosed please find an opinion of counsel.
A check for the filing fee in the amount of   $46,729.35

If there are any questions, please contact the undersigned.

Very truly yours,

IDS Investment Series, Inc.



Leslie L. Ogg
Vice President, General Counsel and Secretary


LLO/CW/rjf

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<TABLE>
<CAPTION>
                                                              IDS Diversified Equity Income Fund             IDS Mutual   
<S>                                                    <C>                             <C>                       <C>
  *  Shares registered in prior years                                                            0                         0

     Share price on                                    November 16, 1995                      8.33                     13.52
                                                                                                                            
     Value of shares                                                                             0                         0
                                                                                                                            

 **  Shares registered in current years                                                          0                         0

     Share price on                                    November 16, 1995                      8.33                     13.52
                                                                                                                            
     Value of shares                                                                             0                         0
                                                                                                                            

***  Aggregate Sales                                                                   307,773,610             1,269,772,647

     Aggregate Redemptions                                                             209,140,489             1,232,890,654
                                                                                                                            
     Securities Sold during Fiscal Year                                                 98,633,121                36,881,993
                                                                                                                            

     Fee                                                                               $34,011.42                 $12,717.93
                                                                                                                            
</TABLE>

EXHIBIT INDEX
(b) (10) OPINION OF COUNSEL

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PAGE 1







November 24, 1995


IDS Investment Series, Inc.
IDS Tower 10
Minneapolis, Minnesota 55440

Gentlemen:

I have examined the Articles of Incorporation and the By-Laws of
the Company and all necessary certificates, permits, minute books,
documents and records of the Company, and the applicable statutes
of the State of Minnesota, and it is my opinion:

(a)  That the Company is a corporation duly organized and existing
     under the laws of the State of Minnesota with an authorized
     capital stock of 10,000,000,000 shares, all of $.01 par value,
     that such shares may be issued as full or fractional shares
     and that on Sept. 30, 1995, 421,924,894 shares were issued and
     outstanding;

(b)  That all such authorized shares are, under the laws of the
     State of Minnesota, redeemable as provided in the Articles of
     Incorporation of the Company and upon redemption shall have
     the status of authorized and unissued shares;

(c)  That the Company registered on Nov. 29, 1992 an indefinite
     number of shares pursuant to Rule 24f-2 and is herewith filing
     a Rule 24f-2 Notice covering the shares sold during its Fiscal
     Period ended Sept. 30, 1995; and

(d)  That shares which were sold at not less than their par value
     and in accordance with applicable federal and state securities
     laws were legally issued, fully paid and nonassessable.

I hereby consent that the foregoing opinion may be used in
connection with the Rule 24f-2 Notice.

Very truly yours,



Leslie L. Ogg
Attorney at Law
901 S. Marquette Ave., Suite 2810
Minneapolis, Minnesota 55402-3268



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