AXP INVESTMENT SERIES INC
N-30D, 1999-12-07
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AXP(SM)
Mutual
1999 ANNUAL REPORT
(PROSPECTUS ENCLOSED)

(icon of) magnifying glass

AXP Mutual seeks to provide shareholders with a balance of growth of capital and
current income.

(This annual report  includes a prospectus  that  describes in detail the Fund's
objective,  investment strategy, risks, sales charges, fees and other matters of
interest. Please read the prospectus carefully before you invest or send money.)



Distributed by American Express Financial Advisors Inc.


AMERICAN EXPRESS Financial Advisors (logo)

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A Beneficial Balance

A balanced portfolio is one of the building blocks of investment  planning.  And
balance is what AXP Mutual is all about. The Fund starts with a focus on stocks,
many of which are part of the who's who of  corporate  America.  To help balance
the  fluctuations  inherent  in  stocks,  as well as provide  greater  income to
investors,  bonds are added to the  portfolio.  The  result:  a Fund that offers
income  above that of a pure stock fund,  while still  providing  potential  for
capital appreciation.

AXP MUTUAL        (This annual report is not part of the prospectus.)

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Table of Contents

1999 ANNUAL REPORT

The purpose of this annual report is to tell investors how the Fund performed.

From the Chairman                         4
From the Portfolio Managers               4
Fund Facts                                6
The 10 Largest Holdings                   7
Making the Most of the Fund               8
The Fund's Long-term Performance          9
Independent Auditors' Report (Fund)      10
Financial Statements (Fund)              11
Notes to Financial Statements (Fund)     14
Independent Auditors' Report (Portfolio) 18
Financial Statements (Portfolio)         19
Notes to Financial Statements (Portfolio)22
Investments in Securities                27
Federal Income Tax Information           42


1999 PROSPECTUS

The prospectus,  which is bound into the middle of this annual report, describes
the Fund in detail.

The Fund                                 3p
Goal                                     3p
Investment Strategy                      3p
Risks                                    5p
Past Performance                         6p
Fees and Expenses                        8p
Management                               9p
Buying and Selling Shares               10p
Valuing Fund Shares                     10p
Investment Options                      10p
Purchasing Shares                       12p
Sales Charges                           15p
Exchanging/Selling Shares               19p
Distributions and Taxes                 24p
Personalized Shareholder Information    25p
Master/Feeder Structure                 26p
About the Company                       27p
Quick Telephone Reference               29p
Financial Highlights                    30p

(This annual report is not part of the prospectus.)  ANNUAL REPORT - 1999

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(picture of) Arne H. Carlson
Arne H. Carlson
Chairman of the board

From the Chairman

American Express(R) Funds held shareholder  meetings in June 1999.  Shareholders
approved all of the proposals advanced by management. Among the proposals were:

o The election of Board members and the selection of KPMG LLP as independent
  auditors.
o Change in the Fund name from "IDS" to "AXP."
o A new shareholder service and distribution plan.
o Changes with respect to fundamental investment policies.

No other business was presented at the meeting,  which was concluded by a report
to shareholders  from the Investment  Department of American  Express  Financial
Corporation.

Thanks to all of you for your effort in reviewing the proxy  material and voting
your proxies.


Arne H. Carlson

(picture of) Kurt Winters
Kurt Winters
Portfolio manager

From the Portfolio Managers

The past 12 months was a volatile but ultimately  rewarding period for financial
assets. For AXP Mutual, the result was a total return of 11.72% (Class A shares)
during the fiscal year -- October 1998 through September 1999. (A portion of the
return came in the form of a capital  gain,  which was paid to  shareholders  in
December  1998 and reduced the Fund's net asset value by the same amount at that
time.)

The period  began with U.S.  stocks  trying to shake off the  effects of a sharp
decline in the late summer of 1998.  But, in another  display of the  remarkable
resilience  it has  shown in recent  years,  the  market  was soon on its way to
making up the lost ground.  Supported by three reductions in short-term interest
rates by the  Federal  Reserve,  the  tentative  advance  quickly  turned into a
roaring rally that lasted through most of the winter.

AXP MUTUAL       (This annual report is not part of the prospectus.)

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(picture of) Brad Stone
Brad Stone
Portfolio manager

After  retreating in February,  stocks made another nice advance that eventually
stalled in mid-summer.  By that time,  long-term interest rates were up markedly
since the start of 1999,  and concern  about  potentially  higher  inflation had
re-surfaced.  The result was a sustained  retreat by stocks over the final three
months.

On the  fixed-income  side of the portfolio,  a rebound by corporate bonds had a
positive   effect  early  in  the  fiscal  year.  But  for  most  of  1999,  the
rising-interest-rate  trend penalized the Fund's  holdings,  which also included
mortgage-backed  and U.S.  Treasury  bonds. We emphasized  higher-quality  bonds
throughout  the period.  Among our  investment  strategies was the purchase of a
modest amount of derivatives, including futures and options.

As for the asset mix, we kept between 55% and 65% of the assets in stocks,  with
almost all the rest in bonds.  The  largest  sector  exposure  was to  financial
services issues,  including those of banks and insurance  companies.  Technology
and utilities  securities  made up the next two largest  weightings.  Although a
comparatively small area of investment,  energy-related  stocks enjoyed a strong
comeback and made a solid contribution to performance.

Changes to the  portfolio  were  relatively  modest.  We lowered the  technology
exposure  somewhat and  increased  the financial  services  holdings  during the
period.  We also  reduced the  duration of the bond side of portfolio to make it
less vulnerable to a potential rise in interest rates,  and lowered the exposure
to mortgage-backed bonds.

As the new fiscal year begins,  it's encouraging that the value stocks this Fund
focuses on made something of a comeback at times during the past 12 months.  But
that doesn't  alter the fact that the stock market as a whole is facing  several
conflicting  factors:  an economy  that  appears  to remain  quite  strong,  the
possibility of higher  inflation and higher interest  rates,  concerns about the
strength of corporate  profits,  a depreciating  U.S.  dollar,  and the ultimate
effect of the Y2K computer  situation.  In light of the uncertainty,  we plan to
maintain a somewhat defensive investment approach with both stocks and bonds.


Kurt Winters


Brad Stone

(This annual report is not part of the prospectus.)  ANNUAL REPORT - 1999

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Fund Facts

Class A-- 12-month performance
(All figures per share)

Net asset value (NAV)

Sept. 30, 1999                                                    $12.94
Sept. 30, 1998                                                    $13.29
Decrease                                                          $ 0.35

Distributions -- Oct. 1, 1998 - Sept. 30, 1999

From income                                                       $ 0.47
From capital gains                                                $ 1.40
Total distributions                                               $ 1.87

Total return*                                                    +11.72%**

Class B -- 12-month performance
(All figures per share)

Net asset value (NAV)

Sept. 30, 1999                                                    $12.86
Sept. 30, 1998                                                    $13.21
Decrease                                                          $ 0.35

Distributions -- Oct. 1, 1998 - Sept. 30, 1999

From income                                                       $ 0.37
From capital gains                                                $ 1.40
Total distributions                                               $ 1.77

Total return*                                                    +10.93%**

Class Y -- 12-month performance
(All figures per share)

Net asset value (NAV)

Sept. 30, 1999                                                    $12.95
Sept. 30, 1998                                                    $13.29
Decrease                                                          $ 0.34

Distributions -- Oct. 1, 1998 - Sept. 30, 1999

From income                                                       $ 0.48
From capital gains                                                $ 1.40
Total distributions                                               $ 1.88

Total return*                                                    +11.90%**

 *The prospectus discusses the effect of sales charges, if any, on the various
  classes.
**The total return is a hypothetical investment in the Fund with all
  distributions reinvested.

AXP MUTUAL      (This annual report is not part of the prospectus.)

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The 10 Largest Holdings

                                       Percent                    Value
                                    (of net assets)     (as of Sept. 30, 1999)

 Citigroup                               2.17%               $102,079,999
 American Intl Group                     1.86                  87,372,187
 Mobil                                   1.85                  87,148,749
 AT&T                                    1.74                  81,997,499
 Intl Business Machines                  1.66                  78,286,874
 Chevron                                 1.63                  76,768,750
 Bank of America                         1.56                  73,229,062
 MCI WorldCom                            1.31                  61,453,124
 Texaco                                  1.22                  57,443,750
 Ameritech                               1.19                  56,101,563

Excludes U.S. Treasury and government agency holdings.

For further detail about these  holdings,  please refer to the section  entitled
"Investments in Securities."


(icon of) pie chart

The 10 holdings listed here
make up 16.19% of net assets

(This annual report is not part of the prospects.)   ANNUAL REPORT - 1999

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Making the Most of the Fund

BUILD YOUR ASSETS SYSTEMATICALLY

One of the best  ways to  invest in the Fund is by  dollar-cost  averaging  -- a
time-tested  strategy  that  can make  market  fluctuations  work  for  you.  To
dollar-cost  average,  simply invest a fixed amount of money  regularly.  You'll
automatically  buy more shares when the Fund's share price is low,  fewer shares
when it is high. The chart below shows how dollar-cost averaging works. In these
three  hypothetical   scenarios,   you  will  see  six  months  of  share  price
fluctuations.

This strategy  does not ensure a profit or avoid a loss if the market  declines.
But, if you can continue to invest regularly  through changing market conditions
even when the price of your  shares  fall or the market  declines,  it can be an
effective way to accumulate shares to meet your long-term goals.

How dollar-cost averaging works

       Jan  Feb  Mar  Apr  May  Jun
$15                   $16  $18  $20
$10    $10  $12  $14
$ 5

Accumulated shares*       Average market           Your average
                          price per share          cost per share

      42.25                    $15                    $14.20
- -------------------------------------------------------------------------------

       Jan  Feb  Mar  Apr  May  Jun
$15
$10    $10                      $10
$ 5         $8   $5   $5   $8

Accumulated shares*       Average market           Your average
                          price per share          cost per share

      85.0                     $7.66                  $7.05
- -------------------------------------------------------------------------------

       Jan  Feb  Mar  Apr  May  Jun
$15
$10    $10  $8   $6             $7
$ 5                   $4   $4

Accumulated shares*       Average market           Your average
                          price per share          cost per share

     103.5                    $6.50                    $5.80
- -------------------------------------------------------------------------------
$100 invested per month. Total invested: $600.

*Shares purchased is determined by dividing the amount invested per month by the
current share price.

THREE WAYS TO BENEFIT FROM A MUTUAL FUND:

o your shares increase in value when the Fund's investments do well
o you receive capital gains when the gains on investments sold by the Fund
  exceed losses
o you receive  income when the Fund's stock  dividends,  interest and short-term
  gains exceed its expenses.

All  three  make up  your  total  return.  You  potentially  can  increase  your
investment if, like most investors, you reinvest your dividends and capital gain
distributions to buy additional shares of the Fund or another fund.

AXP MUTUAL          (This annual report is not part of the prospectus.)

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The Fund's Long-term Performance

How $10,000 has grown in AXP Mutual

$50,000


$40,000

                                                           X
$30,000                                               S&P 500 Index
                                                                            X
                                                                        $26,434
                                                                      AXP Mutual
$20,000
                                                X
                                                Lipper Balanced
$10,000                                         Fund Index



$9,500


10/1/89  9/90  9/91   9/92  9/93   9/94    9/95     9/96    9/97    9/98   9/99

Average annual total return (as of Sept. 30, 1999)

                  1 year          5 years        10 years       Since inception*

 Class A          +6.14%          +11.76%         +10.21%                 --%
 Class B          +7.04%              --%             --%             +12.22%
 Class Y         +11.90%              --%             --%             +13.51%

* Inception date was March 20, 1995.

Assumes:  Holding  period from 10/1/89 to 9/30/99.  Returns do not reflect taxes
payable  on   distributions.   Reinvestment  of  all  income  and  capital  gain
distributions for the Fund, with a value of $6,574.  Also see "Past Performance"
in the Fund's current prospectus.

On the graph  above you can see how the  Fund's  total  return  compared  to two
widely  cited  performance  indexes,  the  Standard  & Poor's 500 Index (S&P 500
Index) and the Lipper  Balanced Fund Index. In comparing AXP Mutual (Class A) to
the two  indexes,  you  should  take  into  account  the fact  that  the  Fund's
performance  reflects the maximum sales charge of 5%, while such charges are not
reflected in the performance of the indexes.

Your investment and return values fluctuate so that your shares,  when redeemed,
may be worth more or less than the original  cost.  Average  annual total return
figures  reflect the impact of the applicable  sales charge,  up to a maximum of
5%. This was a period of widely fluctuating security prices. Past performance is
no guarantee of future results.

S&P 500 Index,  an unmanaged  list of common  stocks,  is  frequently  used as a
general measure of market  performance.  The index reflects  reinvestment of all
distributions and changes in market prices, but excludes  brokerage  commissions
or other fees. However,  the S&P500 companies may be generally larger than those
in which the Fund invests.

Lipper Balanced Fund Index,  an unmanaged  index published by Lipper  Analytical
Services,  Inc.,  includes  30 funds  that are  generally  similar  to the Fund,
although some funds in the index may have somewhat different investment policies
or objectives.

(This annual report is not part of the prospectus.)  ANNUAL REPORT - 1999

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The  financial  statements   contained  in  Post-Effective   Amendment  #101  to
Registration  Statement  No.  2-11328 filed on or about  November 24, 1999,  are
incorporated herein by reference.

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Federal Income Tax Information

(Unaudited)

The  Fund is  required  by the  Internal  Revenue  Code  of  1986  to  tell  its
shareholders  about the tax treatment of the dividends it pays during its fiscal
year. The dividends listed below are reported to you on Form 1099-DIV, Dividends
and  Distributions.  Shareholders  should consult a tax advisor on how to report
distributions for state and local tax purposes.

Class A

Income distributions taxable as dividend income, 34.61% qualifying for deduction
by corporations.

Payable date                                 Per share

Dec. 22, 1998                                 $0.21163
March 25, 1999                                 0.08440
June 24, 1999                                  0.08615
Sept. 23, 1999                                 0.08737
Total                                         $0.46955

Capital gain distribution taxable as long-term capital gain.

Payable date                                 Per share

Dec. 22, 1998                                 $1.40077

Total distributions                           $1.87032

The  distribution  of $1.61240 per share,  payable  Dec. 22, 1998,  consisted of
$0.10432  derived  from net  investment  income,  $0.10731  from net  short-term
capital gains (a total of $0.21163 taxable as dividend income) and $1.40077 from
net long-term capital gains.

AXP MUTUAL       (This annual report is not part of the prospectus.)

<PAGE>

Class B

Income distributions taxable as dividend income, 34.61% qualifying for deduction
by corporations.

Payable date                                 Per share

Dec. 22, 1998                                 $0.18679
March 25, 1999                                 0.05964
June 24, 1999                                  0.06120
Sept. 23, 1999                                 0.06237
Total                                         $0.37000

Capital gain distribution taxable as long-term capital gain.

Payable date                                 Per share

Dec. 22, 1998                                 $1.40077

Total distributions                           $1.77077

The  distribution  of $1.58756 per share,  payable  Dec. 22, 1998,  consisted of
$0.07948  derived  from net  investment  income,  $0.10731  from net  short-term
capital gains (a total of $0.18679 taxable as dividend income) and $1.40077 from
net long-term capital gains.

Class Y

Income distributions taxable as dividend income, 34.61% qualifying for deduction
by corporations.

Payable date                                 Per share

Dec. 22, 1998                                 $0.21403
March 25, 1999                                 0.08709
June 24, 1999                                  0.08895
Sept. 23, 1999                                 0.09251
Total                                         $0.48258

Capital gain distribution taxable as long-term capital gain.

Payable date                                 Per share

Dec. 22, 1998                                 $1.40077

Total distributions                           $1.88335

The  distribution  of $1.61480 per share,  payable  Dec. 22, 1998,  consisted of
$0.10672  derived  from net  investment  income,  $0.10731  from net  short-term
capital gains (a total of $0.21403 taxable as dividend income) and $1.40077 from
net long-term capital gains.

(This annual report is not part of the prospectus.)  ANNUAL REPORT - 1999

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S-6326P (11/99)

AXP Mutual
IDS Tower 10
Minneapolis, MN 55440-0010

AMERICAN EXPRESS Financial Advisors (logo)

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STATEMENT OF DIFFERENCES

Difference                                       Description

1)   The layout is different                     1)  Some of the layout in the
     throughout the annual report.                   annual report to
                                                     shareholders is in two
                                                     columns.

2)   There are pictures, icons                   3)  Each picture, icon and
     and graphs throughout the                       graph is described in
     annual report.                                  parentheses.




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