LILLY ELI & CO
PRE 14A, 1998-02-05
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                                 SCHEDULE 14A

          Proxy Statement Pursuant to Section 14(a) of the Securities
                    Exchange Act of 1934 (Amendment No.  )
        
Filed by the Registrant [_]

Filed by a Party other than the Registrant [X] 

Check the appropriate box:

[X]  Preliminary Proxy Statement         [_]  CONFIDENTIAL, FOR USE OF THE
                                              COMMISSION ONLY (AS PERMITTED BY
                                              RULE 14A-6(E)(2))

[_]  Definitive Proxy Statement 

[_]  Definitive Additional Materials 

[_]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                             Eli Lilly and Company
- --------------------------------------------------------------------------------
               (Name of Registrant as Specified In Its Charter)

                           R. R. Donnelley and Sons
- --------------------------------------------------------------------------------
   (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

   
Payment of Filing Fee (Check the appropriate box):

[X]  No fee required

[_]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

   
     (1) Title of each class of securities to which transaction applies:

     -------------------------------------------------------------------------


     (2) Aggregate number of securities to which transaction applies:

     -------------------------------------------------------------------------


     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
         the filing fee is calculated and state how it was determined):

     -------------------------------------------------------------------------
      

     (4) Proposed maximum aggregate value of transaction:

     -------------------------------------------------------------------------


     (5) Total fee paid:

     -------------------------------------------------------------------------

[_]  Fee paid previously with preliminary materials.
     
[_]  Check box if any part of the fee is offset as provided by Exchange
     Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.
     
     (1) Amount Previously Paid:
 
     -------------------------------------------------------------------------


     (2) Form, Schedule or Registration Statement No.:

<PAGE>
 
                                      LOGO


                             Eli Lilly and Company
                             Lilly Corporate Center
                          Indianapolis, Indiana 46285
                                        
                                        

                                                                   March 4, 1998

Dear Shareholder:

     You are cordially invited to attend our Annual Meeting of Shareholders on
Monday, April 20, 1998. The meeting will be at the Hilbert Circle Theatre, 45
Monument Circle, Indianapolis, Indiana, at 11:00 a.m. (Indianapolis time).

     The Notice of Annual Meeting of Shareholders and the Proxy Statement
accompanying this letter describe the business we will consider at the meeting. 
In particular, please note that management is requesting the shareholders to 
approve three items in addition to the election of directors and the 
ratification of the Board of Directors appointment of independent auditors.

     As the number of available authorized shares of the Company's common stock
was greatly reduced as a result of the two-for-one stock split this past
September we recommend increasing the number of authorized shares of common
stock. Management also recommends that the shareholders approve two important
performance incentive programs for officers and other employees, a new employee
stock plan and an amended cash bonus plan.
                
Your vote is very important. I urge you to sign, date, and return the enclosed
proxy card in the envelope provided in order to be certain your shares are
represented at the meeting, even if you plan to attend the meeting.

     I look forward to seeing you at the meeting.



                                  LOGO
                                  Randall L. Tobias
                                  Chairman of the Board and
                                  Chief Executive Officer




<PAGE>
 
                             ELI LILLY AND COMPANY
                                        
                               ________________
                                        
                                        
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                                        
                                 April 20, 1998
                                        
     The Annual Meeting of Shareholders of Eli Lilly and Company will be held at
the Hilbert Circle Theatre, 45 Monument Circle, Indianapolis, Indiana, on
Monday, April 20, 1998, at 11:00 a.m. (Indianapolis time), for the following
purposes:

     1. To elect four directors of the Company, each for a three-year term;

     2. To amend the Articles of Incorporation to increase the authorized number
        of shares of common stock from 1,600,000,000 to 3,200,000,000 shares;

     3. To approve the 1998 Lilly Stock Plan;

     4. To approve the amended EVA Bonus Plan;

     5. To ratify the appointment by the Board of Directors of Ernst & Young LLP
        as principal independent auditors for the year 1998; and

     6. To transact any other business properly before the Annual Meeting.

     Shareholders of record at the close of business on February 13, 1998, will
be entitled to vote at the meeting and any adjournments thereof.

     Attendance at the meeting will be limited to shareholders, those holding
proxies from shareholders, and invited guests from the media and financial
community. Admission to the meeting will be by Admittance Card or other evidence
of share ownership. If you plan to attend the meeting, please complete and
return the enclosed Request for Admittance Card and we will mail you an
Admittance Card and directions to the meeting.

     If you want to attend the Annual Meeting but your shares are held in the
name of a broker or other nominee, please send proof of share ownership to the
Corporate Secretary, DC 1093, Lilly Corporate Center, Indianapolis, Indiana
46285 to receive an Admittance Card. This Proxy Statement, proxy and the
Company's Annual Report to Shareholders are being mailed on or about March 4,
1998.

                              By order of the Board of Directors,


                              Daniel P. Carmichael
                              Secretary


March 4, 1998
Indianapolis, Indiana

- --------------------------------------------------------------------------------
Your vote is important. Please date, sign, and mail promptly the enclosed proxy,
for which a return envelope is provided, even if you plan to attend the Annual
Meeting.
<PAGE>
 
                             ELI LILLY AND COMPANY

                                Proxy Statement
                                ________________

                         ANNUAL MEETING OF SHAREHOLDERS

                                 April 20, 1998

     This Proxy Statement is furnished in connection with the solicitation by
the Board of Directors of Eli Lilly and Company (the "Company") of proxies to
be voted at the Annual Meeting of Shareholders to be held on Monday, April 20,
1998, and at any adjournment thereof.  The following is important information in
a question-and-answer format regarding the Annual Meeting and this Proxy
Statement.

Q:  What am I voting on?
    Election of four directors (Dr. Steven C. Beering, Dr. Franklyn G.
    Prendergast, Mrs. Kathi P. Seifert and Mr. Randall L. Tobias)
 .   Increase the authorized number of shares of common stock by amending the
    Articles of Incorporation
 .   Approval of 1998 Lilly Stock Plan
 .   Approval of the Eli Lilly and Company EVA Bonus Plan
 .   Ratification of Ernst & Young LLP as the Company's independent accountants

Q:  Who is entitled to vote?
Shareholders as of the close of business on February 13, 1998 (the "Record
Date") are entitled to vote at the Annual Meeting.  Each shareholder is entitled
to one vote for each share of common stock held on the Record Date.

Q:  How do I vote?
Sign and date each proxy card you receive and return it in the prepaid envelope.
If you return your signed proxy card but do not indicate your voting
preferences, we will vote FOR the five proposals on your behalf.  You have the
right to revoke your proxy any time before the meeting by (1) notifying the
Company's Secretary, or (2) returning a later-dated proxy.  You may also revoke
your proxy by voting in person at the meeting.

Q:  What does it mean if I get more than one proxy card?
It means you hold shares registered in more than one account.  Sign and return
all proxy cards to ensure that all your shares are voted.

Q:  Who will count the vote?
Representatives of The Corporation Trust Company will tabulate the votes and act
as inspectors of election.

Q:  What constitutes a quorum?
A majority of the outstanding shares, present or represented by proxy,
constitutes a quorum for the Annual Meeting.  As of the Record Date, ______
shares of Lilly common stock were issued and outstanding.  Proxies submitted by
brokers that do not indicate a vote for some of the proposals because the
holders do not have discretionary voting authority and have not received
instructions from the beneficial owners on how to vote on those proposals are
called "broker non-votes."
<PAGE>
 
Q:  How many votes are needed for approval of each item?
There are differing vote requirements for the various proposals. Directors will
be elected by a plurality of the votes cast at the Annual Meeting, meaning the
four nominees receiving the most votes will be elected directors. Only votes
cast for a nominee will be counted, except that the accompanying proxy will be
voted for the four management nominees unless the proxy contains instructions to
the contrary. Abstentions, broker non-votes, and instructions on the
accompanying proxy card to withhold authority to vote for one or more of the
nominees will result in those nominees receiving fewer votes. However, such
action will not reduce the number of votes otherwise received by the nominee.

The approvals of the 1998 Lilly Stock Plan and the EVA Bonus Plan each require
an affirmative vote of a majority of the shares present in person or by proxy
and entitled to vote at the Annual Meeting. For these proposals, an abstention
will have the same effect as a vote against the proposal. Broker non-votes will
not be voted for or against the proposals and will not be counted as entitled to
vote.

The amendment to the Articles of Incorporation requires an affirmative vote of a
majority of the shares outstanding and entitled to vote as of the Record Date.
Abstentions and broker non-votes will have the same effect as votes against
proposal.

Finally, ratification of the auditors requires that the number of votes cast for
ratification exceed those cast against ratification. Abstentions and broker non-
votes will have no effect on this vote.

Q:  Who can attend the Annual Meeting?
All shareholders as of the Record Date can attend. Eligible shareholders must
request an Admittance Card by returning the enclosed Request for Admittance
Card. If your shares are held in the name of a broker or other nominee, please
send proof of share ownership to the Company's Secretary, DC 1093, Lilly
Corporate Center, Indianapolis, Indiana 46285 to receive an Admittance Card.


Q:  What percentage of stock do the directors and officers own?
Together, they own approximately ___% of Lilly common stock as of the Record
Date. (See page 7 for details.)


Q:  Who are the largest principal shareholders?
Lilly Endowment, Inc. owned 179,189,368 shares, or 16.136%, as of December 31,
1997. National City Bank, Indiana held 61,415,953 shares (or 5.530%), as of
December 31, 1997, in various fiduciary capacities. (See page 8 for details.)


Q:  When are shareholder proposals for the 1999 meeting due?
The Company's 1999 Annual Meeting is scheduled for April 19, 1999. To be
considered for inclusion in next year's Proxy Statement, shareholder proposals
must be submitted in writing by November 4, 1998, to the Company's Secretary, DC
1093, Lilly Corporate Center, Indianapolis, Indiana 46285. In addition, the
Company's By-laws provide that any shareholder wishing to nominate a candidate
for director or propose other business at the Annual Meeting must give the
Company written notice 90 days before the meeting, and the notice must provide
certain other information as described in the By-laws. Copies of the By-laws are
available to shareholders free of charge upon request to the Company's
Secretary.

                                       2
<PAGE>
 
                        ITEM 1.  ELECTION OF DIRECTORS
                                        
     Under the Company's Articles of Incorporation, the Board is divided into
three classes with approximately one-third of the directors standing for
election each year for a three-year term. Nominees for election this year are:
Dr. Steven C. Beering, Dr. Franklyn G. Prendergast, Mrs. Kathi P. Seifert and
Mr. Randall L. Tobias. Each has consented to serve for an additional term.

     If any director is unable to stand for election, the Board may, by
resolution, provide for a lesser number of directors or designate a substitute.
In the latter event, shares represented by proxies may be voted for a substitute
director.


Biographical Information

     Information as of January 31, 1998 regarding each director, including each
director nominated for election, is set forth on the following pages.

Nominees for director for three-year terms ending in 2001:
     The Board recommends a vote FOR the nominees.

             Steven C. Beering, M.D.                  Director since 1983
             President, Purdue University             Age 65

             Dr. Beering has served as President of Purdue University since
             1983. He served as Dean of the Indiana University School of
             Medicine and Director of the Indiana University Medical Center from
             1974 until 1983. Dr. Beering is a fellow of the American College of
             Physicians and the Royal Society of Medicine and a member of the
             National Academy of Sciences Institute of Medicine. He is a
             director of American United Life Insurance Company; Arvin
             Industries, Inc.; Veridian Corporation; and NIPSCO Industries, Inc.
             Dr. Beering is the past national chairman of the Association of
             American Universities.

             Franklyn G. Prendergast, M.D., Ph.D.     Director since 1995
             Edmond and Marion Guggenheim             Age 52
             Professor of Biochemistry and Molecular
             Biology, Mayo Medical School and
             Director, Mayo Cancer Center

             Dr. Prendergast is the Edmond and Marion Guggenheim Professor of
             Biochemistry and Molecular Biology at Mayo Medical School. He also
             serves as the Director of the Mayo Cancer Center. Dr. Prendergast
             has held several other teaching positions at the Mayo Medical
             School since 1975. Dr. Prendergast serves on the Board of Trustees
             of Mayo Foundation.

             Kathi P. Seifert                         Director since 1995
             Group President,                         Age 48
             North American Personal Care Products,
             Kimberly-Clark Corporation

             Mrs. Seifert is Group President, North American Personal Care
             Products, for Kimberly-Clark Corporation, responsible for the
             Infant Care, Child Care, Feminine Care, and Adult Care Businesses
             as well as the U.S. and Canadian sales forces. She joined Kimberly-
             Clark in 1978 and has served in several capacities in connection
             with both the domestic and international marketing of consumer
             products. Mrs. Seifert is director of the Aid Association for
             Lutherans and United Health Group of Wisconsin. She also is a
             member of the Chancellor's Advisory Board of the University of
             Wisconsin in Oshkosh.

                                       3
<PAGE>
 
             Randall L. Tobias                        Director since 1986
             Chairman of the Board and                Age 55
             Chief Executive Officer

             Mr. Tobias became Chairman of the Board and Chief Executive Officer
             of the Company in 1993. Prior to assuming this position, he served
             as Vice Chairman of the Board of AT&T from 1986 until 1993, and as
             Chairman and Chief Executive Officer of AT&T International (an AT&T
             subsidiary) from 1991 to 1993. Mr. Tobias is a director of     
             Kimberly-Clark Corporation; Knight-Ridder, Inc.; and Phillips 
             Petroleum Company. He also serves as Chairman of the Board of
             Trustees of Duke University.

             
Directors continuing in office until 1999:

             Alfred G. Gilman, M.D., Ph.D.            Director since 1995
             Regental Professor and Chairman,         Age 56
             Department of Pharmacology, The
             University of Texas Southwestern
             Medical Center at Dallas

             Dr. Gilman has served as Professor and Chairman of the Department
             of Pharmacology at The University of Texas Southwestern Medical
             Center at Dallas since 1981. He has held the Raymond and Ellen
             Willie Distinguished Chair in Molecular Neuropharmacology at the
             University since 1987 and was named a Regental Professor in 1995.
             Dr. Gilman was on the faculty of the University of Virginia School
             of Medicine from 1971 until 1981, where he was named a Professor of
             Pharmacology in 1977. He is a director of Regeneron
             Pharmaceuticals, Inc. Dr. Gilman was a recipient of the Nobel Prize
             in Physiology or Medicine in 1994.

             Karen N. Horn, Ph.D.                     Director since 1987
             Senior Managing Director and             Age 54
             and Head of International Private
             Banking, Bankers Trust Company

             Mrs. Horn has served as the Managing Director and head of
             International Private Banking at Bankers Trust Company since
             October 1996. Prior to joining Bankers Trust, she served as
             Chairman of the Board, Bank One Cleveland, N.A., President of the
             Federal Reserve Bank of Cleveland, Treasurer of Bell of
             Pennsylvania, and Vice President of First National Bank of Boston.
             Mrs. Horn is a director of The British Petroleum Company p.l.c.;
             Rubbermaid Incorporated; and TRW, Inc. She also serves as a trustee
             of The Rockefeller Foundation and The Cleveland Clinic Foundation.

             J. Clayburn La Force, Jr., Ph.D.         Director since 1981
             Dean Emeritus, The John E. Anderson      Age 69
             Graduate School of Management,
             University of California at Los Angeles

             Dr. La Force served as Dean of The John E. Anderson Graduate School
             of Management of the University of California at Los Angeles
             ("UCLA") from 1978 until he retired in 1993. He joined the
             faculty of UCLA in 1962 and served as Chairman of the Economics
             Department. Dr. La Force is a director of BlackRock Funds; Imperial
             Credit Industries, Inc.; Payden & Rygel Investment Trust; Provident
             Investment Council Mutual Funds; Rockwell International
             Corporation; Jacobs Engineering Group, Inc.; the Timken Company;
             and Motor Cargo Industries. He also is chairman of the board of
             directors of the Foundation for Research in Economics and
             Education.

                                       4
<PAGE>
 
             August M. Watanabe, M.D.                 Director since 1994
             Executive Vice President,                Age 56
             Science and Technology

             Dr. Watanabe has served as Executive Vice President, Science and
             Technology, since February 1996. Prior to joining the Company, he
             was on the faculty of the Indiana University School of Medicine
             from 1972 to 1990, serving as Professor and Chairman of the
             Department of Medicine between 1983 and 1990. He joined the Company
             in 1990 as Vice President of Lilly Research Laboratories and was
             named Group Vice President of Lilly Research Laboratories in 1992.
             He was appointed a Vice President of the Company and elected to the
             Board of Directors in 1994. He is a fellow of the American College
             of Physicians and the American College of Cardiology and a director
             of the Indiana University Foundation.

Directors continuing in office until 2000:

             Evan Bayh                                Director since 1997
             Partner, Baker & Daniels                 Age 42

             Mr. Bayh became a partner in the law firm of Baker & Daniels,
             Indianapolis, Indiana, in January 1997. From January 1989 until
             January 1997, he served as Governor of the State of Indiana. Prior
             to being elected Governor, Mr. Bayh served as Secretary of State
             for Indiana from 1987 until 1989. Mr. Bayh is a director of Great
             Lakes Chemical Corporation; Indianapolis Life Insurance Company;
             Dominick's Finer Foods, Inc.; and Fortis, Inc. He also serves as
             chairman of the National Education Goals Panel.

             Charles E. Golden                        Director since 1996
             Executive Vice President                 Age 51
             and Chief Financial Officer

             Mr. Golden joined the Company as Executive Vice President and Chief
             Financial Officer in 1996. Prior to joining the Company, he served
             as Vice President of General Motors Corporation ("GM"), and
             Chairman and Managing Director of Vauxhall Motors Limited, a
             subsidiary of GM in the United Kingdom, from 1993 to 1996. Mr.
             Golden joined GM in 1970 and held a number of executive positions
             in that company's domestic and international operations. Mr. Golden
             is a director of Clarian Health Partners and is a member of the
             U.S. advisory board of INSEAD.

             Kenneth L. Lay, Ph.D.                    Director since 1993
             Chairman of the Board and                Age 55
             Chief Executive Officer,
             Enron Corp.

             Mr. Lay has served Enron Corp. as Chairman of the Board since 1986
             and its Chief Executive Officer since 1985. He joined Enron as
             President and Chief Operating Officer in 1985. Prior to joining
             Enron, he served as Chairman and Chief Executive Officer of Houston
             Natural Gas and as President, Chief Operating Officer, and a
             director of Transco Energy Company. Mr. Lay is a director of Compaq
             Computer Corporation and Trust Company of the West.

                                       5
<PAGE>
 
             Sidney Taurel                            Director since 1991
             President and Chief                      Age 49
             Operating Officer

             Mr. Taurel was elected President and Chief Operating Officer of the
             Company in February 1996. He joined the Company in 1971 and has
             held management positions in the Company's operations in Brazil and
             Europe. He served as President of Eli Lilly International
             Corporation from 1986 until 1991, as Executive Vice President of
             the Pharmaceutical Division from 1991 until 1993 and as Executive
             Vice President of the Company from 1993 until 1996. Mr. Taurel is
             Chairman of the Board of Directors of the Pharmaceutical Research
             and Manufacturers of America; a director of both ITT Industries,
             Inc. and The McGraw-Hill Companies, Inc.; and a Member of the Board
             of Overseers of the Columbia Business School.

             Alva O. Way                              Director since 1980
             Chairman of the Board, IBJ               Age 68
             Schroder Bank & Trust Company

             Mr. Way became Chairman of the Board of IBJ Schroder Bank & Trust
             Company in 1986. He also serves as a director of and consultant to
             Schroder p.l.c., London, and related companies. Mr. Way previously
             served as President of both The Travelers Corporation and American
             Express Company and served in executive positions at General
             Electric Company. He is a director of Gould, Inc.; The McGraw-Hill
             Companies, Inc.; Ryder System, Inc.; and Schroder p.l.c. Mr. Way
             also serves as a member of the Board of Fellows and Chancellor
             Emeritus of Brown University.


     During 1997 the Board of Directors held seven meetings. Each director
attended at least 75% of the aggregate of the total number of meetings of the
Board of Directors and the total number of meetings of all committees of the
Board of Directors on which the director served.


Committees of the Board

Audit Committee
Members:  Directors Way (Chair), Bayh, Beering and Prendergast
Number of Meetings in 1997:  Three
Functions:
 .    Oversees internal controls, audits and compliance program
 .    Recommends independent accountants and oversees their activities

Compensation and Management Development Committee
Members:  Directors Beering (Chair), Horn, Lay and Way
Number of Meetings in 1997:  Six
Functions:
 .    Establishes executive officers' compensation
 .    Administers Deferred Compensation Plan, certain stock plans and EVA Plan

Finance Committee
Members:  Directors Lay (Chair), Golden, Horn and Seifert
Number of Meetings in 1997:  Two
Functions:
 .    Reviews current and long-range financial strategy and planning, including
     budgets, dividends and borrowings

                                       6
<PAGE>
 
Public Policy Committee
Members:  Directors LaForce (Chair), Bayh, Gilman, Seifert and Taurel
Number of Meetings in 1997:  Three
Functions:
 .    Reviews policies, practices and procedures relating to social, political,
     legal and economic issues affecting the Company

Science and Technology Committee
Members:  Directors Prendergast (Chair), Beering, Gilman, LaForce, and Watanabe
Number of Meetings in 1997:  Three
Functions:
 .    Reviews and makes recommendations regarding Company's strategic research
     goals and objectives
 .    Reviews new developments, technologies and trends in pharmaceutical
     research and development


Directors and Corporate Governance Committee
Members:  Directors Horn (Chair), Beering, LaForce, Lay and Tobias (ex officio)
Number of Meetings in 1997:  Two
Functions:
 .    Recommends candidates for membership on the Board and Board committees
 .    Considers candidates for the Board recommended by shareholders
 .    Considers matters of corporate governance
 .    Reviews and establishes compensation of non-employee directors
This Committee will consider a candidate for director proposed by a shareholder.
A candidate must be highly qualified and be both willing and expressly
interested in serving on the Board. A shareholder wishing to propose a candidate
for the Committee's consideration should forward the candidate's name and
information about the candidate's qualifications to the Company's Secretary.

Common Stock Ownership by Directors and Executive Officers

     The following table sets forth the number of shares of Company common stock
beneficially owned by the directors, the Named Executive Officers listed on page
10, and all directors and executive officers as a group, as of December 31,
1997. 

<TABLE>
<CAPTION>

 
            Name of Individuals or                                           Shares Owned
              Identity of Group                                             Beneficially(1)
          --------------------------                                        ---------------

<S>                                                                         <C>          <C>
          Evan Bayh.....................................................            662
          Steven C. Beering, M.D........................................         20,621
          Alfred G. Gilman, M.D., Ph.D..................................          3,670
          Charles E. Golden.............................................         34,532  (2)
          Rebecca O. Goss...............................................         56,894  (3)
          Karen N. Horn, Ph.D...........................................         16,179
          J. Clayburn La Force, Jr., Ph.D...............................         26,216
          Kenneth L. Lay, Ph.D..........................................         43,661  (4)
          Franklyn G. Prendergast, M.D..................................          7,496
          Kathi P. Seifert..............................................          8,941
          Sidney Taurel.................................................        214,618  (5)
          Randall L. Tobias.............................................        353,771  (6)
          August M. Watanabe, M.D.......................................        381,957  (7)
          Alva O. Way...................................................         27,522  (8)
          All directors and executive officers as a group (28 persons)..      2,151,528
- ---------
</TABLE>

(1)  Unless otherwise indicated in a footnote, each person listed in the table
     possesses sole voting and sole investment power with respect to the shares
     shown in the table to be owned by that person. The shares shown

                                       7
<PAGE>
 
     do not include the following shares that may be purchased pursuant to stock
     options that are exercisable within 60 days of December 31, 1997: Ms. Goss,
     148,800 shares; Mr. Taurel, 788,800 shares; Mr. Tobias, 1,200,000 shares;
     Dr. Watanabe, 90,616 shares; and all directors and executive officers as a
     group, _________ shares. The shares shown include, in the case of employees
     of the Company, shares credited to the accounts of the employees under The
     Lilly Employee Savings Plan ("Savings Plan") and, in case of non-employee
     directors and Mr. Tobias, shares credited to the director's account under
     the Lilly Directors' Deferral Plan. No person listed in the table owns more
     than .0344% of the outstanding common stock of the Company. All directors
     and executive officers as a group own 1.94% of the outstanding common stock
     of the Company.
(2)  The shares shown for Mr. Golden include 230 shares credited to his account
     under the Savings Plan.
(3)  The shares shown for Ms. Goss include 7,875 shares credited to her account
     under the Savings Plan. Ms. Goss' children have sole voting power and sole
     investment power with respect to 191 shares that are included in the table.
(4)  Mr. Lay has shared voting power and shared investment power with respect to
     20,220 shares that are included in the table and are owned by a family
     partnership of which he is a partner.
(5)  The shares shown for Mr. Taurel include 12,693 shares credited to his
     account under the Savings Plan.
(6)  Mr. Tobias' wife has sole voting power and sole investment power with
     respect to 93,400 shares that are included in the table. In addition, she
     has shared voting and investment power over 3,300 shares that are included
     in the table and are owned by family trusts of which she is a trustee. Mr.
     Tobias disclaims any beneficial interest in all of such shares. Mr. Tobias
     has shared voting power and shared investment power with respect to 84,000
     shares that are included in the table and are owned by three separate
     foundations of which he is a director. The shares shown for Mr. Tobias
     include 1,516 shares credited to his account under the Savings Plan.
(7)  The shares shown for Dr. Watanabe include 3,475 shares credited to his
     account under the Savings Plan.
(8)  Mr. Way's wife owns 720 shares of those shown in the table, and he
     disclaims any beneficial interest therein.

Principal Holders of Common Stock

     To the best of the Company's knowledge, and except as set out below, Lilly
Endowment Inc., (the "Endowment") is the only beneficial owner of more than 5%
of the outstanding shares of the Company's common stock. The following table
sets forth information regarding this ownership as of December 31, 1997:

<TABLE> 
<CAPTION> 

                                   Number of Shares      Percent
     Name and Address              Beneficially Owned    of Class
     ----------------              ------------------    --------
<S>                                <C>                   <C> 
     Lilly Endowment, Inc.            179,189,368        16.136%
     2801 North Meridian Street
     Indianapolis, Indiana 46208
</TABLE> 

     The Endowment has sole voting and sole investment power with respect to
these shares. The Endowment may be deemed to be a parent of the Company as that
term is defined for purposes of the Securities Act of 1933. The Board of
Directors of the Endowment is composed of Mr. Thomas H. Lake, Honorary Chairman;
Mr. Thomas M. Lofton, Chairman; Otis R. Bowen, M.D.; Mrs. Mary K. Lisher; Drs.
William G. Enright, Earl B. Herr, Jr., and Herman B Wells; and Messrs. Byron P.
Hollett, Eli Lilly II, and Eugene F. Ratliff. Drs. Bowen, Enright, and Herr and
Messrs. Hollett, Lake, Lilly, Lofton, and Ratliff are shareholders of the
Company.

     As of December 31, 1997, National City Bank of Indiana ("NCBI") held
61,415,953 shares of the Company's common stock (5.530% of the outstanding
shares) in various fiduciary capacities. Over half of the shares are held by it
as trustee under the Savings Plan, savings plans of affiliated companies, and
the employee stock ownership plan. In addition, NCBI holds such shares for
various parties in personal trusts, agency and custodial accounts, pension
accounts, estates, and guardianships. NCBI has sole voting power with respect to
27,145,952 shares, shared voting power with respect to 196,950 shares, sole
investment power with respect to 4,965,973 shares, shared investment power with
respect to 12,952,238 shares, and the right to vote an additional shares in the
savings plans to the extent it is not instructed on how to vote such shares by
plan participants.

                                       8
<PAGE>
 
Directors' Compensation

     Employee directors receive no additional compensation for serving on the
Board or its Committees. Non-employee directors receive a retainer of $2,915 per
month and $1,600 for each Board meeting attended. In addition, they are paid
$1,600 for each Committee or other meeting attended, if that meeting is not held
on the same day as a Board meeting. Directors are also reimbursed for customary
and usual travel expenses. The Company does not have a retirement plan for non-
employee directors.

     Under the Lilly Directors' Deferral Plan, directors may elect to defer all
or part of their cash compensation in either a Deferred Compensation Account or
a Deferred Stock Account. Amounts in the Deferred Compensation Account earn
interest at 2% above the prime interest rate annually (as adjusted each
December). The aggregate amount of interest accrued for the participating
directors in 1997 was $166,050.

     Compensation deferred in the Deferred Stock Account is credited in the form
of hypothetical shares of the Company's common stock based on the market price
of the stock at the time of the deferral. Hypothetical dividends are
"reinvested" into additional shares based on the market price of the stock on
the date dividends are paid. In addition, on the first business day in December,
the Company credits each non-employee director's Deferred Stock Account with the
lesser of 800 shares or the number of shares at the market price on that date
equaling the value of the director's total annual cash compensation if he/she
attended all regularly scheduled Board meetings. In 1997, each non-employee
director's Deferred Stock Account was credited with 662 shares. All shares in
the Deferred Stock Accounts are hypothetical and are not issued or transferred
until the director resigns or dies. The shares credited to all non-employee
directors' Deferred Stock Accounts are included in the share ownership table on
page 7. At the director's election, upon retirement or resignation from the
Board, the Deferred Compensation Account will be paid in a lump sum or in annual
or monthly installments for up to 10 years, and the Deferred Stock Account will
be paid in a lump sum or in annual installments for up to 10 years.


Performance Graph

     The following performance graph compares the cumulative total shareholder
return on the Company's common stock with Standard & Poor's 500 Stock Index and
the Peer Group* for the years 1993 through 1997. The graph is constructed on the
assumption that $100 was invested on December 31, 1992, in each of the Company's
common stock, the S&P 500 Stock Index, and the Peer Group common stock.


               Comparison of Five-Year Cumulative Total Return**
               Among Lilly, S&P 500 Stock Index, and Peer Group



                                    [GRAPH]
<TABLE> 
<CAPTION> 

- --------------------------------------------------------------------------------
            Eli Lilly             Peer Group 1       Peer Group 2        S&P 500
- --------------------------------------------------------------------------------
<S>         <C>                   <C>                <C>                 <C> 
     Dec-92          $100.00           $100.00            $100.00        $100.00
- --------------------------------------------------------------------------------
     Dec-93          $102.41            $91.63             $92.57        $110.03
- --------------------------------------------------------------------------------
     Dec-94          $118.22           $103.49            $106.02        $111.53
- --------------------------------------------------------------------------------
     Dec-95          $208.87           $165.13            $168.68        $153.29
- --------------------------------------------------------------------------------
     Dec-96          $276.66           $209.94            $211.27        $188.39
- --------------------------------------------------------------------------------
     Dec-97          $534.92           $314.00            $316.27        $251.17
- --------------------------------------------------------------------------------
</TABLE> 
<TABLE> 
<CAPTION> 
                                         Fiscal Years Ended December 31
                      -------------------------------------------------------------------
                        1992       1993        1994        1995        1996        1997
                      -------     -------     -------     -------     -------     -------
<S>                   <C>         <C>         <C>         <C>         <C>         <C>
Lilly.............    $100.00     $102.41     $118.22     $208.87     $276.66     $534.92
S&P 500...........    $100.00     $110.03     $111.53     $153.29     $188.39     $251.17
Peer Group 1......    $100.00      $91.63     $103.49     $165.13     $209.94         314
Peer Group 2......    $100.00      $92.57     $106.02     $168.68     $211.27     $316.27
</TABLE> 

*    The Peer Group has been constructed by the Company as the industry index
     for purposes of the performance graph and is comprised of eleven companies
     in the pharmaceutical industry used by the Company in 1997 to benchmark
     compensation of executive officers. The eleven companies are: Abbott
     Laboratories; American Home Products Corporation; Bristol-Myers Squibb
     Company; Glaxo Holdings p.l.c.; Johnson & Johnson; Merck & Co.; Pfizer,
     Inc.; Pharmacia & Upjohn, Inc.; Schering-Plough Corporation; SmithKline
     Beecham p.l.c.; and Warner-Lambert Company. That Peer Group is identified
     on the graph as Peer Group 1. Peer Group 2 appears on the graph as it was
     the Peer Group of companies used by the Company for benchmarking


                                       9
<PAGE>

     executive compensation prior to 1997. Peer Group 2 includes nine of the
     companies in Peer Group 1, excluding Johnson & Johnson and Schering-Plough.

**   Total return assumes reinvestment of dividends.

Executive Compensation

Summary Compensation Table

     The following Summary Compensation Table show the compensation paid to Mr.
Tobias, who served as Chief Executive Officer of the Company during 1997, and
the four most highly compensated executive officers other than Mr. Tobias who
were serving as executive officers as of December 31, 1997.  These five
individuals are the "Named Executive Officers."


                           Summary Compensation Table
<TABLE>
<CAPTION>
                                                                                                     Long Term
                                                                                                  Compensation(1)
                                                                                 -------------------------------------------------
                                             Annual Compensation                     Awards                           Payouts
                                          -------------------------              -------------------------------------------------
                                                                                                   Number of
                                                                                                  Securities
                                                                     Other                        Underlying      Long-Term
                                                                    Annual        Restricted        Options       Incentive
Name and Principal Position  Year    Salary        Bonus         Compensation      Stock (3)        Granted      Plan Payout
- ---------------------------  ----  ----------  -------------    ---------------  -------------  ---------------  ------------
<S>                          <C>   <C>         <C>              <C>               <C>            <C>              <C>
Randall L. Tobias            1997  $1,200,000    $1,298,074(2)     $214,055                         225,000      $1,661,280(4)
  Chairman of the Board      1996   1,100,000     1,152,111         149,216                         150,000       2,470,463
  Chief Executive Officer    1995     984,000       983,167          42,170                         300,000       1,697,988

Sidney Taurel                1997     860,000       650,778(2)      154,686                         125,000       1,245,960(4)
  President and Chief        1996     786,700       578,667         123,148                          75,000       1,313,625
  Operating Officer          1995     660,000       520,300          76,134                         150,000         902,875

August Watanabe, M.D.        1997     636,000       518,534(2)       24,671                          60,000         899,860(4)
  Executive Vice President,  1996     579,900       459,800          18,386                          40,000       1,135,650
  Science and Technology     1995     419,400       381,700          35,705                          80,000         780,550

Charles E. Golden            1997     636,000       492,649(2)       12,230                          60,000         824,872(4)
  Executive Vice President   1996     497,600       945,371(6)      184,633(7)     $801,625         100,000             -0-
  and Chief Financial
  Officer

Rebecca O. Goss              1997     413,880       299,985(2)       12,273                          40,000         692,200(4)
  Vice President and         1996     329,880       267,127           5,491                          20,000         872,925
  General Counsel            1995     257,880       249,840          15,259                          40,000         262,125
</TABLE>

<TABLE>
<CAPTION>
                                        Long Term
                                     Compensation(1)
                                     ---------------
                                         Payouts
                                     ---------------
                                        All Other
Name and Principal Position           Compensation
- ---------------------------          --------------
<S>                                          <C>
Randall L. Tobias                       $72,004(5)
  Chairman of the Board                  66,002
  Chief Executive Officer                59,040

Sidney Taurel                            51,602(5)
  President and Chief                    47,202
  Operating Officer                      39,600

August Watanabe, M.D.                    38,160(5)
  Executive Vice President,              34,794
  Science and Technology                 25,164

Charles E. Golden                        38,160(5)
  Executive Vice President                9,000
  and Chief Financial
  Officer

Rebecca O. Goss                          24,833(5)
  Vice President and                     19,973
  General Counsel                        15,473
</TABLE>

(1)  During the years indicated, stock appreciation rights were not granted.

(2)  Amounts earned under the EVA Bonus for 1997 and paid in 1998. An additional
     amount was earned for 1997 but not paid in 1998. The additional amount will
     be either paid in later years or forfeited, depending on the extent to
     which future annual financial performance goals under the Eva Bonus Plan
     are achieved.

(3)  Mr. Golden was awarded 25,000 shares of restricted stock when he joined the
     Company as a means of replacing a portion of certain equity-based
     compensation he forfeited when he resigned from his previous employer to
     become an Executive Vice President of the Company. Dividends will be paid
     on the restricted stock awarded to Mr. Golden which was valued at
     $1,740,625 at December 31, 1997. Dr. Watanabe has 32,000 shares of
     restricted stock valued at $2,228,000 on December 31, 1997.

(4)  Amounts paid in Company common stock (except for amounts paid in cash to
     satisfy tax withholding requirements) in February 1998 and the performance
     award program for the period January 1, 1996 through December 31, 1997.

(5)  Company contribution to the named individual's account in the Savings Plan.

(6)  Mr. Golden's 1996 bonus was composed of $352,121 paid in cash under the EVA
     Bonus Plan as described in footnote (2) and $593,250 paid in stock (except
     for tax withholding amounts) under the performance award program for the
     1996 calendar year.

(7)  Includes relocation expenses incurred as a result of Mr. Golden's move from
     the United Kingdom to Indiana in 1996.

                                      10
<PAGE>
 
Stock Option Grants

     The following table provides information on options to purchase Company
common stock granted in 1997 to the Named Executive Officers under the 1994
Lilly Stock Plan.

                  Option Shares Granted in Last Fiscal Year(1)

<TABLE>
<CAPTION>
                                                Individual Grants
- ------------------------------------------------------------------------------------------------------------------

                                   Number of      % of Total
                                   Securities     Option
                                   Underlying     Shares Granted    Exercise or                      Grant Date
                                   Options        to Employees      Base Price        Expiration     Present
             Name                  Granted        in Fiscal Year    Per Share(2)      Date           Value(4)
             ----                --------------  ----------------  --------------  ----------------  -------------
<S>                              <C>             <C>               <C>             <C>               <C>
Randall L. Tobias..............         225,000              3.76       $64.06          10/19/07(3)    $3,506,805

Sidney Taurel..................         125,000              2.09        64.06          10/19/07(3)     1,948,225

August M. Watanabe, M.D........          60,000              1.00        64.06          10/19/07(3)       935,148

Charles E. Golden..............          60,000              1.00        64.06          10/19/07(3)       935,148

Rebecca O. Goss................          40,000              0.66        64.06          10/19/07(3)       623,432
</TABLE>

(1) Stock appreciation rights were not granted during 1997.
(2) Options are granted at the market price of Company common stock on the date
    of grant.
(3) These options will become exercisable October 21, 2000.
(4) These values were established using the Black-Scholes stock option valuation
    model. Assumptions used to calculate the grant date present value of option
    shares granted during 1997 were in accordance with SFAS 123, as follows:
     (a) Expected Volatility--The standard deviation of the continuously
         compounded rates of return calculated on the average daily stock price
         over a period of time immediately preceding the grant and equal in
         length to the expected life. The volatility was 21.5%.
     (b) Risk-Free Interest Rate--The rate available at the time the grant was
         made on zero-coupon U.S. Government issues with a remaining term equal
         to the expected life. The risk-free interest rate was 6.18%.
     (c) Dividend Yield--The expected dividend yield was 3.14% based on the
         historical dividend yield over a period of time immediately preceding
         the grant date equal in length to the expected life of the grant.
     (d) Expected Life--The expected life of the grant was seven years,
         calculated based on the historical expected life of previous grants.
     (e) Forfeiture Rate--Under SFAS 123, forfeitures may be estimated or
         assumed to be zero. The forfeiture rate was assumed to be zero.

                                       11
<PAGE>
 
Stock Option Exercises and Option Values

  The following table contains information concerning stock options exercised
during 1997 and stock options unexercised at the end of 1997 with respect to the
Named Executive Officers.

           Aggregated Option Shares Exercised in Last Fiscal Year and
                        Fiscal Year-End Option Values(1)

<TABLE>
<CAPTION>
                                  Number of
                                  Shares                      Number of Securities             Value of Unexercised,
                                  Acquired     Value          Underlying Unexercised           In-the-Money Options
                                  On Exercise  Realized       Options at Fiscal Year-End       at Fiscal Year-End(2)
                                  -----------  -------------  -------------------------------  ---------------------------
Name                                                          Exercisable      Unexercisable   Exercisable   Unexercisable
- ----                                                          -----------      -------------   -----------   -------------
<S>                               <C>          <C>            <C>              <C>             <C>           <C>
Randall L. Tobias...............  -0-          -0-            1,200,000        1,125,000       $68,513,000   $39,843,187

Sidney Taurel...................  51,200       $1,578,368     788,800          575,000         43,644,832    19,995,062

August M. Watanabe, M.D.........  278,384      10,944,774     90,616           300,000         5,012,863     10,624,850

Charles E. Golden...............  -0-          -0-            -0-              260,000         -0-           7,961,150

Rebecca O. Goss.................  -0-          -0-            148,800          160,000         8,313,119     5,371,200
</TABLE>

(1) Stock appreciation rights were not exercised during 1997 and no stock
    appreciation rights were outstanding on December 31, 1997.
(2) Represents the amount by which the market price of the common stock of the
    Company exceeded the exercise prices of unexercised options on December 31,
    1997.

Long-Term Incentive Awards

  The following table provides information on long-term performance awards
granted in 1997 to the Named Executive Officers under the 1994 Lilly Stock Plan.

              Long-Term Incentive Plan Awards in Last Fiscal Year
<TABLE>
<CAPTION>

                                                           Estimated Future Payments Under
                                                            Non-Stock Price Based Plans(2)
                                                            ------------------------------
                                   Number of     Performance
                                   Shares        Period Until  Threshold  Target   Maximum
Name                               Awarded(1)    Payout        #Shares    #Shares  #Shares
- ----                               ---------     ------------  ---------  -------  -------
<S>                                <C>           <C>           <C>        <C>      <C>
Randall L. Tobias................     28,000     2 years          18,700   28,000   56,000
Sidney Taurel....................     19,000     2 years          12,670   19,000   38,000
August M. Watanabe, M.D..........      9,000     2 years           6,000    9,000   18,000
Charles E. Golden................      9,000     2 years           6,000    9,000   18,000
Rebecca O. Goss..................      5,600     2 years           3,740    5,600   11,200
</TABLE>
(1) Represents the targeted award amount payable in the year 2000 if earned for
    the fiscal years 1998-1999 award period.
(2) Payouts are determined by the aggregate earnings per share ("EPS") level for
    the award period. The target amount will be paid if 100% of the targeted EPS
    is achieved; the threshold amount will be paid if at least 96.55% of the
    targeted EPS is achieved; and the maximum amount will be paid if 110.87% or
    more of the targeted EPS is achieved. No payment will be made unless at
    least 96.55% of the targeted EPS level is achieved.

                                       12
<PAGE>
 
Compensation and Management Development Committee Report

     The Compensation and Management Development Committee consists of four non-
employee directors. The Committee regularly reviews the Company's executive
compensation policies and practices and establishes the salaries of executive
officers. The Committee also administers the Deferred Compensation Plan, the
EVA Plan and the 1994 Lilly Stock Plan, the stock plan covering executive
officers and other members of management.

     A. Executive Compensation Policy

     The Committee's executive compensation policy is founded on principles that
guide the Company in establishing all its compensation programs. The Company
designs compensation programs to attract, retain, and motivate highly talented
individuals at all levels of the organization. In addition, the programs are
designed to be cost-effective and to treat all employees fairly. To that end,
all programs, including those for executive officers, share these
characteristics:

     .  Compensation is based on the level of job responsibility, individual
performance, and Company performance. Members of senior management have a
greater portion of their pay based on Company performance than other employees.

     .  Compensation also reflects the value of the job in the marketplace. To
retain its highly skilled work force, the Company strives to remain competitive
with the pay of other highly respected employers who compete with the Company
for talent.

     .  To align the interests of employees with those of shareholders, the
Company provides employees worldwide at all levels of the organization the
opportunity for equity ownership through various Company programs. In addition,
executive officers and other key employees worldwide have the opportunity to
build more substantial equity ownership through Company stock plans.

     .  Compensation programs are developed and administered to foster the long-
term focus required for success in the research-based pharmaceutical industry.

     The Committee believes that the Company's executive compensation program
reflects the principles described above and provides executives strong
incentives to maximize Company performance and therefore enhance shareholder
value. The program consists of both annual and long-term components. The
Committee believes that the executive compensation program should be considered
as a whole in order to properly assess whether it is attaining its objectives.

     In establishing total compensation, the Committee considers various
measures of historical and projected Company performance, including sales, net
income, return on shareholders' equity, return on sales and assets, sales and
net income per employee, total market value and total shareholder return. These
data form the basis for the Committee's assessment of the overall performance
and prospects of the Company that underpins the Committee's judgment in
establishing total compensation ranges. In evaluating these factors the
Committee does not assign them relative weights or rankings; rather it makes a
subjective determination based on a collective consideration of all such
factors.

     The Committee also compares the Company's total compensation package (and,
to the extent meaningful, the compensation of individual executive officers)
with those global pharmaceutical companies of comparable size and stature to the
Company that constitute the "Peer Group" for the Performance Graph on page 9.
The Peer Group companies are identified in a footnote to the Performance Graph.
The Committee uses the Peer Group data primarily as benchmarks to ensure that
the executive compensation program as a whole is within the broad middle range
of comparative pay of the Peer Group companies. The Committee does not target a
specific position in the range of comparative data for each individual or for
each component of compensation. Individual amounts are established in view of
the comparative data and such other factors as level of responsibility, prior
experience, and the Committee's subjective judgment as to individual
contribution. These factors are not assigned specific mathematical weights;
            
                                      13
<PAGE>
 
rather, the Committee exercises its judgment and discretion in the information
it reviews and the analysis it considers.

     The Company also retains independent compensation and benefits consultants
to assist in evaluating executive compensation programs. The use of independent
consultants provides additional assurance that the Company's programs are
reasonable and appropriate to the Company's objectives.

     B. Components of Executive Compensation

     Annual Cash Compensation. Annual cash compensation for 1997 consisted of
two components, base salary and a cash bonus under the EVA Plan.

     Base salaries are determined with reference to Company and individual
performance for the previous year, internal relativity, and market conditions,
including pay at the Peer Group companies and general inflationary trends.
Assessment of individual performance includes consideration of a person's impact
on financial performance as well as judgment, creativity, effectiveness in
developing subordinates and a diverse organization, and contributions to
improvement in the quality of the Company's products, services, and operations.
As noted above, the Committee uses the Peer Group and other market data to test
for reasonableness and competitiveness of base salaries but also exercises
subjective judgment in view of the Company's compensation objectives.

     Cash bonuses for management are paid under the EVA Plan, a formula-based
plan that is based on the concept of Economic Value Added ("EVA")*. In basic
terms, EVA is after-tax operating profit less the annual total cost of capital.
Under the EVA Plan, the size of bonuses varies directly with the amount by which
after-tax operating profit exceeds the cost of capital. Thus, the EVA Plan
rewards managers who increase shareholder value by most effectively deploying
the capital contributed by the shareholders. The EVA Plan places bonuses "at
risk" in that if the Company fails to achieve the target EVA, the bonuses
earned can be reduced or even be negative, resulting in a reduction of future
years' bonuses. The EVA Plan is more fully described below under the caption
"Item 4 -Proposal to Approve Amended EVA Bonus Plan." The Committee determines
the participants and sets the target bonus levels prior to the beginning of the
year. As to the executive officers, the Committee's intent is to set target
bonuses within the broad middle range of Peer Group companies.

     Long-Term Incentives. The Company employs two forms of long-term incentives
granted under the 1994 Lilly Stock Plan, performance awards and stock options.
These incentives foster the long-term focus necessary for continued success in
the research-based pharmaceutical business. They also provide individuals in
leadership roles the opportunity for substantial equity ownership to ensure
proper focus on shareholder value. Performance awards and stock options have
traditionally been granted broadly and deeply within the organization, with over
2,000 management and professional employees now participating.

     Performance awards provide recipients the opportunity to earn shares of
Company common stock annually if certain performance goals are achieved. The
awards, which are granted annually, are structured as a schedule of shares of
common stock based on the Company's achievement of specific cumulative earnings-
per-share ("EPS") levels over a two-year award period. Individual award size
varies depending on the recipient's level of responsibility.

  Stock options are an important part of the Company's performance-based
compensation. Stock options provide a strong incentive to increase shareholder
value, since Company stock options have value only if the stock price increases
over time. The Company's 10-year options, granted at the market price on the
date of grant, ensure that employees are oriented to growth over the long term
and not simply to short-term profits. In addition, the options encourage
retention because they carry a three-year vesting period and, if not exercised,
are forfeited if the employee leaves the Company before retirement. The size of
grants to executive officers in 1997 was based primarily on the recipient's
level of responsibility. The Committee also considered the size of grants to
individuals in previous years and internal relativity.

*"EVA" is a trademark of Stern, Stewart & Company, a compensation and benefits
consulting firm.
                
                                      14
<PAGE>
 
     Adjustments for Extraordinary Events. Consistent with past practices, the
Committee adjusted the financial results on which awards were determined under
the 1996-97 performance awards to minimize or eliminate the effect on earnings
per share of accounting adjustments and other extraordinary non-operating items.
The purpose of the adjustments is to ensure that award payouts reflect ongoing
operating results and are not artificially inflated or deflated due to one-time
non-operating events. Adjustments were made to eliminate the extraordinary
income effect, and to eliminate or reduce the effect of extraordinary charges,
resulting from certain business development and licensing arrangements, asset
dispositions, and asset writedowns during the award period.

     Deductibility Cap on Executive Compensation. Federal income tax law
disallows corporate deductibility for certain compensation paid in excess of $1
million to the chief executive officer and the four other most highly paid
executive officers ("Named Executive Officers"). "Performance-based
compensation," as defined in the tax law, is not subject to the deductibility
limitation provided certain shareholder approval and other requirements are met.
Stock option and performance award compensation of the Named Executive Officers
under the 1994 Lilly Stock Plan qualifies as "performance-based compensation,"
and therefore is fully deductible. Stock options and performance award
compensation under the 1998 Plan (as described more fully below under caption
"Item 3 - Approval of the 1998 Lilly Stock Plan") will also qualify for full
deductibility if the plan is approved by the shareholders at the 1998 Annual
Meeting. Finally, the Board of Directors is submitting the EVA Plan to a vote of
the shareholders at the 1998 Annual Meeting in order to assure full
deductibility of EVA payments to the Named Executive Officers in the future. See
"Item 4 - Proposal to Approve Amended EVA Bonus Plan."

     C. Chief Executive Officer Compensation

     The compensation of Mr. Tobias, Chairman of the Board and Chief Executive
Officer, consists of the same components as for other senior executives, namely
base salary, EVA bonus, performance awards, and stock options.

     In establishing Mr. Tobias' 1997 compensation, the Committee applied the
principles outlined above in the same manner as they were applied to the other
executives.  The Committee reviewed Company performance relative to the Peer
Group companies, based on a number of factors including sales, earnings, return
on sales and assets, return on equity and total shareholder return. The
Committee did not assign these factors relative weights or rankings but rather
made a subjective determination after considering all such factors collectively.
The Committee also noted Mr. Tobias' success in 1996 in focusing employees'
efforts to improve operating results and in leading senior management to develop
a new strategic plan.

     Mr. Tobias' base salary for 1997 was increased to $1,200,000.  This salary
was within the middle range of Peer Group Chief Executive Officers. The
Committee believed this increase was appropriate in light of Mr. Tobias' strong
individual performance as described above.

     The 1997 EVA Plan bonus target for Mr. Tobias was set at $1,000,000, the
same as the previous year. Bonus size was consistent with the goal of placing a
substantial proportion of Mr. Tobias' pay "at risk." The bonus was also targeted
to be within the broad middle range relative to other Chief Executive Officers
of Peer Group companies.

     In October 1997 the Committee provided Mr. Tobias a performance award to be
earned over the two-year award period 1998-99. If earnings per share performance
targets are achieved, the award will pay out 28,000 shares of Lilly common stock
in the year 2000.  In determining the size of the award, the Committee
considered Mr. Tobias' level of responsibility and internal relativity.  As with
the awards to other senior executives, the award size for Mr. Tobias was
increased modestly to maintain competitiveness with other Peer Group programs.
However, the earnings-per-share hurdles for minimum, target, and maximum payouts
were increased over previous years.  In light of activities during the award
period involving business development initiatives, the Committee adjusted Mr.
Tobias' payout under the 1996-97 performance award to reduce the effect of the
one-time accounting charges and to eliminate the effect of extraordinary gains
during the award period.

     In October 1997 the Committee also granted Mr. Tobias an option to purchase
225,000 shares of Company common stock at $64.06 per share, the market price on
the date of the grant. In determining the size of the grant, the Committee
considered Mr. Tobias' strong leadership as described above. The Committee also
took note of the 
              
                                      15
<PAGE>
 
number of option shares previously granted to Mr. Tobias.  The award size was
consistent with the goal of placing a greater portion of Mr. Tobias' total pay
"at risk."

               Compensation and Management Development Committee

                      Steven C. Beering, M.D., Chairperson

          Karen N. Horn, Ph.D       Kenneth L. Lay Ph.D      Alva O. Way


Compensation Committee Interlocks

     Mr. Tobias served on the Compensation Committee of the Board of Directors
of Kimberly-Clark Corporation during 1997, during which time Mrs. Seifert, Group
President of Kimberly-Clark Corporation, served as a director of the Company.


Retirement Plan

     The Pension Plan Table sets forth a range of annual retirement benefits
under The Lilly Retirement Plan ("Retirement Plan") for graduated levels of
average annual earnings (consisting of Salary, Bonus, and Long-Term Incentive
Plan Payouts as set forth in the Summary Compensation Table on page 10) and
years of service for the life of a retired employee, assuming retirement at age
65 with a 50% survivor income benefit.  The amounts shown in the table are not
subject to deduction for social security benefits.


                               Pension Plan Table
                                        
<TABLE>
<CAPTION>

  Average Annual
 Earnings (Highest                                       Years of Service
5 of Last 10 Years)        -----------------------------------------------------------------------------
- -------------------
                               15          20         25         30         35         40        45
                           ----------  ---------  ---------  ---------  ---------  ---------  ---------
<S>                        <C>          <C>        <C>        <C>        <C>        <C>        <C>
    $  750,000                            206,380    257,980    309,585    361,185    361,185    364,960
     1,000,000                            276,600    345,760    414,910    484,060    484,060    486,595
     1,500,000                            417,030    521,300    625,560    729,815    729,815    729,895
     2,000,000                            557,465    696,845    836,210    975,575    975,575    975,575
     2,500,000                            697,900    872,385  1,046,860  1,221,335  1,221,335  1,221,335
     3,000,000                            838,335  1,047,925  1,257,510  1,467,095  1,467,095  1,467,095
     3,500,000                            978,765  1,223,470  1,468,160  1,712,855  1,712,855  1,712,855
     4,000,000                          1,119,200  1,399,010  1,678,810  1,958,610  1,958,610  1,958,610
     4,500,000                          1,259,635  1,574,555  1,889,460  2,204,370  2,204,370  2,204,370
     5,000,000                          1,400,070  1,750,095  2,100,115  2,450,130  2,450,130  2,450,130
     5,280,000                          1,478,710  1,848,400  2,218,075  2,587,755  2,587,755  2,587,755
</TABLE>

     The years of service credited to the Named Executive Officers are Mr.
Tobias, 19 years; Mr. Taurel, 26 years; Ms. Goss, 20 years; Dr. Watanabe, 16
years; and Mr. Golden, 28 years.  Mr. Golden's ultimate pension benefit from the
Retirement Plan will be reduced by the amount of the pension payments he
receives from his previous employer.

     Section 415 of the Internal Revenue Code ("Code") generally places a limit
of $130,000 on the amount of annual pension benefits that may be paid at age 65
from a plan such as the Company's Retirement Plan.  The Code also places a
$10,000 limit, subject to adjustment by the Internal Revenue Service, on annual
contributions by an employee to the Company's Savings Plan and, in addition,
imposes a combined limitation when an employee is covered by both types of
plans.  Under an unfunded plan adopted in 1975, however, the Company will make
payments as permitted by the Code to any employee who is a participant in the
Retirement Plan or the Savings Plan in an amount equal to the difference, if
any, between the benefits that would have been payable under such plans

                                       16
<PAGE>
 
without regard to the limitations imposed by the Code and the actual benefits
payable under such plans as so limited.


Change-in-Control Severance Pay Arrangements

     The Company has adopted a change-in-control severance pay program
("Program") covering most employees of the Company and its subsidiaries,
including the Company's executive officers. In general, the Program would
provide severance payments and benefits to eligible employees and executive
officers in the event of their termination of employment under certain
circumstances within fixed periods of time following a change in control. A
"change-in-control" would occur if 20% or more of the Company's voting stock
were acquired by an entity other than the Company, a subsidiary, an employee
benefit plan of the Company, or the Endowment. There are additional conditions
that could result in a change-in-control event. The Program is not subject to
amendment by the Board, whether prior to or following a change-in-control, in
any manner adverse to a participant without his or her prior written consent.

  Under the portion of the Program covering the Named Executive Officers, each
would be entitled to severance payments and benefits in the event that his or
her employment is terminated following a change-in-control (i) without "cause"
by the Company; (ii) for "good reason" by the executive officer, each as is
defined in the Program; or (iii) for a limited period of time, for any reason by
the executive officer. In such case, the executive officer would be entitled to
a severance payment equal to three times his or her current annual cash
compensation. Additional benefits would include a pension supplement and full
and immediate vesting of all stock options and other equity incentives. In the
event that any payments made in connection with the change-in-control would be
subject to the excise tax imposed under Section 4999 of the Internal Revenue
Code as a result of the aggregate compensation payments and benefits made to the
individual, under the Program or otherwise, in connection with a change-in-
control, the Company is obligated to make whole the individual with respect to
such excise tax.


Certain Business Relationships

     During the past calendar year, the Company, in the normal course of
business, utilized the services of the law firm of Baker & Daniels, in which Mr.
Bayh is a partner. The Company plans to continue using the services of the firm
in 1998.


           ITEM 2.  PROPOSAL TO AMEND THE ARTICLES OF INCORPORATION
          TO INCREASE THE NUMBER OF SHARES OF AUTHORIZED COMMON STOCK
                                        
     The Board of Directors recommends an amendment to the Articles of
Incorporation to increase the authorized common stock of the Company from the
presently authorized number of 1,600,000,000 shares to 3,200,000,000 shares. The
language in Article 4 of the existing Articles of Incorporation would be amended
as follows:

     "The total number of shares which the Corporation shall have authority to
     issue is 3,205,000,000 shares, consisting of 3,200,000,000 shares of Common
     Stock and 5,000,000 shares of Preferred Stock. The Corporation's shares do
     not have any par or stated value, except that, solely for the purpose of
     any statute or regulation imposing any tax or fee based upon the
     capitalization of the Corporation, each of the Corporation's shares shall
     be deemed to have a par value of $0.01 per share."

     In September 1997, the Company authorized a two-for-one stock split to be
effected in the form of a 100% stock dividend.  The stock dividend was paid on
October 15, 1997.  This reduced significantly the number of authorized but
unissued shares of common stock available to the Company for future use.  As of
December 31, 1997, there were 1,110,521,927 shares of common stock issued and
outstanding.
     
                                      17
<PAGE>
 
     The proposed increase in the number of shares of authorized common stock
will ensure that shares can be issued if needed, in connection with stock
splits, stock dividends, acquisitions, and other corporate purposes. The Board
of Directors believes that it is beneficial to the Company to have the
additional shares available for such purposes without delay or the necessity of
a special shareholders' meeting. The Company has no immediate plans,
arrangements, commitments, or understandings with respect to the issuance of any
of the additional shares of common stock which would be authorized by the
proposed amendment.

     No further action by the Company's shareholders would be necessary to issue
the additional shares of common stock unless required by applicable law or
regulatory agencies or by the rules of any stock exchange on which the Company's
securities may then be listed.

     The holders of any of the additional shares of common stock issued in the
future would have the same rights and privileges as the holders of the shares of
common stock currently authorized and outstanding.  Those rights do not include
preemptive rights with respect to the future issuance of any additional shares.

     As stated above, the Company has no immediate plans, arrangements,
commitments, or understandings with respect to the issuance of any additional
shares of common stock which would be authorized by the proposed amendment.
However, the increased authorized shares could be used to make a takeover
attempt more difficult such as by using the shares to make a counter-offer for
the shares of the bidder or by selling shares to dilute the voting power of the
bidder.  As of this date, the Board is unaware of any effort to accumulate the
Company's shares or to obtain control of the Company by means of a merger,
tender offer, solicitation in opposition to management or otherwise.

     The current Articles contain other provisions that may be viewed as having
possible anti-takeover effects.  Under these provisions the Company's Board of
Directors is divided into three classes, with approximately one-third of the
members of the Board nominated for election each year.  Thus, two Annual
Meetings are necessary for a majority shareholder to replace a majority of
incumbent directors.  In addition, directors may be removed only for cause and
only upon the affirmative vote of the holders of 80% of the outstanding voting
power of the Company.  The current Articles further provide that, in certain
situations, the affirmative vote of the holders of 80% of the Company's
outstanding voting power is required to approve certain business transactions
(such as mergers or sales of assets) involving another entity that beneficially
owns 5% or more of the voting power of the Company.  The current Articles also
provide that the Board, when evaluating such transactions, shall, in connection
with the exercise of its judgment in determining what is in the best interest of
the Company and its shareholders, give due consideration to all relevant factors
including the social and economic effects on employees, customers, suppliers,
and other constituents of the Company and on the communities in which the
Company operates or is located.

     On July 18, 1988, the Company adopted a ten year Shareholder Rights Plan.
Under the terms of the Plan, all shareholders of common stock received, for each
share owned, a preferred stock purchase right entitling them to purchase from
the Company one eight-hundredth of a share of Series A Participating Preferred
Stock at an exercise price of $40.625. The rights are not exercisable until
after the date on which the company's right to redeem has expired. The Company
may redeem the right for $.00125 per right up to and including the tenth
business date after the date of a public announcement that a person (the
"Acquiring Person") has acquired ownership of stock having 20% or more of the
Company's general voting power (the "Stock Acquisition Date"). The Plan provides
that if the company is acquired in a business combination transaction at any
time after a Stock Acquisition Date, generally each holder of a right will be
entitled to purchase at the exercise price a number of the acquiring company's
shares having a market value of twice the exercise price. The Plan also provides
that in the event of certain other business combinations, certain self-dealing
transactions, or the acquisition by a person of stock having 25% or more of the
Company's general voting power, generally each holder of a right will be
entitled to purchase at the exercise price a number of shares of the Company's
common stock having a market value of twice the exercise price. Any rights
beneficially owned by an Acquiring Person shall not be entitled to the benefit
of the adjustment with respect to the number of shares described above. 

     The Company is not proposing any increase in the number of shares of
authorized preferred stock of which 5,000,000 shares are authorized but have not
been issued.  A total of 1,400,000 shares of the preferred stock have been
designated as Series A Participating Preferred Stock and reserved for issuance
pursuant to the Shareholder 
            
                                      18
<PAGE>
 
Rights Plan discussed above. The Board (subject to applicable law or rules of
regulatory agencies and requirements of stock exchanges) has the power to issue
the existing preferred stock without further shareholder approval, with such
rights as the Board deems advisable, including conversion rights, redemption
rights, voting rights, and liquidation rights. The preferred stock could be
issued to deter a takeover by establishing the terms of the preferred stock so
as to make the takeover substantially more expensive. The preferred stock could
also be issued with voting rights intended to make acquisition of the Company
more difficult.

     The Board recommends a vote FOR amending the Articles of Incorporation to
increase the number of authorized shares of common stock.



            ITEM 3.  PROPOSAL TO APPROVE THE 1998 LILLY STOCK PLAN
                                        
     Stock plans that allow employees to increase ownership of Company stock
have been an integral part of the Company's compensation programs for nearly 50
years.  The Board believes that the shareholders have benefited from these plans
over the years as the plans enable the Company to attract and retain employees
who enhance the value of the Company, and align the interests of employees with
those of shareholders through increased employee ownership of the Company.
Therefore, the Board of Directors has adopted, subject to shareholder approval,
the 1998 Lilly Stock Plan ("1998 Plan").  The Board adopted the 1998 Plan at
this time because only ____ shares of the Company's common stock remain
available for future grants under the stock plan currently in effect, the 1994
Lilly Stock Plan ("1994 Plan").  The 1998 Plan, which is very similar to the
1994 Plan it will replace, will become effective upon approval by the
shareholders.

     Under the 1998 Plan grants may be made to officers and any employees of the
Company selected by the Compensation and Management Development Committee of the
Board (the "Committee"), the Committee that will administer the Plan.  Currently
approximately 31,200 employees, including 19 executive officers and employee
directors, are eligible to participate.  The number of eligible employees and
grantees will vary from year to year.

     The Committee that administers the 1998 Plan is composed entirely of non-
employee directors.  The committee is authorized to grant up to 55,000,000
shares of the Company's common stock ("Lilly Stock"), which represents less than
5% of the company's outstanding shares, in the form of stock options,
performance awards, and restricted stock.  The number of shares available for
grant may be adjusted in the event of a stock split, stock dividend, spin-off or
other relevant change affecting Lilly Stock.  The 1998 Plan, like the 1994 Plan,
does not permit the grant of stock appreciation rights.  The 1998 Plan also
maximizes the deductibility of certain grants under section 162(m) of the
Internal Revenue Code of 1986, as amended (the "Code").  The 1998 Plan will
expire on the fifth anniversary of its effective date unless terminated earlier
by the Board.

     The principal features of the Plan are summarized below.  The Summary is
qualified in its entirety by reference to the full text of the 1998 Plan, which
is attached to this Proxy Statement as Exhibit A.


Shares Subject to Plan

     Subject to adjustment as described below, a maximum of 55,000,000 shares of
Lilly Stock may be issued or transferred for grants under the 1998 Plan.  The
shares may be unissued shares or treasury shares.  In the event of a stock
split, stock dividend, spin-off, or other relevant change affecting Lilly Stock,
the Committee may adjust the number of shares available for grants and the
number of shares and price under outstanding grants made before the event.


Grants Under the 1998 Plan

     Stock Options.  The Committee may grant nonqualified options, Incentive
Stock Options ("ISOs") and other forms of tax-favored stock options under the
Code. The Committee shall establish the option price, which may not be less than
100% of the fair market value of the stock on the date of grant. Options may not
be repriced.
               
                                      19
<PAGE>
 
The term of the option and the period during which it may be exercised are
also established by the Committee, provided that the term may not exceed 10
years.  The option price may be satisfied in cash or, if permitted by the
Committee, by delivering to the Company previously-acquired Lilly Stock having a
fair market value equal to the option price.  No grantee may receive options for
more than 1,500,000 shares under the 1998 Plan in any period of any three
consecutive calendar years.

     Performance Awards.  The Committee may grant performance awards under which
payment would be made in shares of Lilly Stock, cash, or both if the financial
performance of the Company or a subsidiary, division, or other unit of the
Company ("Business Unit") selected by the Committee meets certain financial
goals during an award period.  A maximum of 18,000,000 shares may be issued
under the 1998 Plan in the form of performance awards.  The financial goals are
established by the Committee at the beginning of the award period and are
limited to earnings per share, net income, divisional income; EVA; Market Value
Added ("MVA") or any of the foregoing before the effect of acquisitions,
divestitures, accounting changes, and restructuring and special charges.
The financial goals may also include total shareholder return or Lilly Stock
price goals. For a description of the concept of EVA, please refer to the
discussion below under the caption "Item 4 -Proposal to Approve Amended EVA
Bonus Plan" in this Proxy Statement. MVA is a concept related to EVA which
measures the degree to which employment of capital results in growth in the
market value of the Company. The Committee also establishes the award period
(four or more consecutive fiscal quarters), the maximum payment value of an
award, and the minimum financial performance required before a payment is made.
Awards may be denominated either in shares of Lilly Stock ("Stock Performance
Awards") or in dollar amounts ("Dollar Performance Awards"). The maximum number
of shares that may be received by an individual in payment of Stock Performance
Awards in any calendar year is 100,000. As to Dollar Performance Awards, the
maximum payment to an individual in any calendar year is $4,000,000. The
Committee can elect to pay cash in lieu of part or all of shares of Lilly Stock
payable under an award, and such cash payment shall be deemed a payment of
shares (based on the market value of Lilly Stock on the payment date) for
purposes of determining compliance with the maximum payment limitation for Stock
Performance Awards. In order to receive payment, a grantee must remain employed
by the Company to the end of the award period, except that the Committee may
make complete or partial exceptions to that rule. The Committee may impose
additional conditions on a grantee's entitlement to receive payment under a
performance award.

     At any time prior to payment, the Committee can adjust awards for the
effect of unforeseen events that have a substantial effect on the performance
goals and would otherwise make application of the performance goals unfair.
However, no adjustment may be made that would cause payment of the award to fail
to be fully deductible by the Company under section 162 (m) of the Code.

     Restricted Stock Grants.  The Committee may also issue or transfer shares
under a restricted stock grant.  A maximum of 2,000,000 shares may be issued
under the 1998 Plan in the form of restricted stock grants.  The grant will set
forth a restriction period during which the grantee must remain employed by the
Company.  The stock certificate will be held by the Company in escrow until the
restriction period lapses.  If the grantee's employment terminates during the
period, the grant terminates and the shares are returned to the Company.
However, the Committee can provide complete or partial exceptions to that
requirement as it deems equitable.  The grantee cannot dispose of the shares
prior to the expiration of the restriction period.  During this period, the
grantee is entitled to vote the shares and receive dividends.  Upon lapse of the
restrictions, the stock certificate is delivered to the grantee.

U.S. Federal Income Tax Consequences of Stock Options

     The grant of a stock option will not result in taxable income at the time
of grant for the optionee or the Company.  The grantee will have no taxable
income upon exercising an ISO (except that the alternative minimum tax may
apply), and the Company will receive no deduction when an ISO is exercised.  
Upon exercising a nonqualified stock option, the grantee will recognize ordinary
income in the amount by which the fair market value exceeds the option price;
the Company will be entitled to a deduction for the same amount.  The treatment
to a grantee of a disposition of shares acquired through the exercise of an
option depends on how long the shares are held and on whether the shares were
acquired by exercising an ISO or a nonqualified stock option.  Generally, there
will be no tax consequence to the Company when shares acquired under an option
are disposed of except that the Company may be entitled to a deduction if shares
acquired upon exercise of an ISO are disposed of before the applicable ISO
holding periods have been satisfied.

                                       20
<PAGE>
 
Authority of Committee

     The 1998 Plan will be administered and interpreted by the Committee, each
member of which must be a "non-employee" director within the meaning of Rule
16b-3 under the Securities Exchange Act of 1934, as amended and an "outside
director" within the meaning of section 162 (m) of the Code.  The Committee will
select persons to receive grants from among the eligible employees, determine
the type of grants and number of shares to be awarded to grantees, and set the
terms and conditions of the grants.  The Committee may establish rules for
administration of the 1998 Plan.

Other Information

     The Board may amend the 1998 Plan as it deems advisable, except that
shareholder approval is required for any amendment that would (i) allow the
repricing of Stock Options, (ii) allow the grant of Stock Options at an Option
Price below fair market value of Lilly Stock on the date of grant, (iii)
increase the number of shares authorized for issuance or transfer, or (iv)
increase any of the various maximum limits established for stock options,
performance awards, and restricted stock.  The Committee may amend outstanding
grants consistent with the 1998 Plan if the amendment does not impair the
grantee's rights or upon the agreement of the grantee.

     In the event of a Change-in-Control (as defined in Article 9 of the 1998
Plan), in order to preserve all of the Grantee's rights the following shall
occur, unless the Committee expressly provides otherwise in the grant agreement:
(i) any outstanding stock option not already exercisable shall become
immediately exercisable; (ii) any restriction periods on restricted stock grants
shall immediately lapse; and (iii) outstanding performance awards will be vested
and paid out on a prorated basis, based on the maximum award opportunity and the
number of months elapsed compared to the total number of months in the award
period.

     The Committee has made no determinations as to any grants or awards under
the 1998 Plan.  During 1997, performance awards were granted under the 1994 Plan
to the Named Executive Officers as set forth in the table on page 12 entitled 
"Long-Term Incentive Awards in Last Fiscal Year."  In 1997, the Committee 
granted the following performance awards under the 1994 Plan to the following
groups:

<TABLE>
<CAPTION>

Group                                                Number of Shares
- -----                                              --------------------
                                        Minimum    Target      Maximum
                                        -------    -------    ---------
<S>                                     <C>        <C>        <C>
Executive Officers (21 persons).......     0       113,550      227,100

Non-Executive Officer Employees.......     0       873,575    1,747,150
</TABLE>

     During 1997, stock options were granted under the 1994 Plan to the Named
Executive Officers as set forth in the table on page ___ entitled "Option Shares
Granted in Last Fiscal Year."  Also during 1997, the Committee granted stock
options under the 1994 Plan for 311,000 shares to all executive officers as a
group at an exercise price of $64.06 per share and 5,154,040 shares to non-
executive officer employees as a group at an exercise price of $64.06 per share.
In 1997, the Committee did not ISSUE any restricted stock grants under the 1994
Plan.

     The closing price of Lilly Stock on the New York Stock Exchange on February
___, 1998, was $______ per share.

     The Board recommends that you vote FOR approval of the 1998 Lilly Stock
Plan.


              ITEM 4.  PROPOSAL TO APPROVE AMENDED EVA BONUS PLAN


     In 1995 the Board of Directors adopted a bonus plan, the Eli Lilly and
Company EVA Bonus Plan ("EVA Plan"), that provides incentive compensation to
selected employees based on a measure of "Economic Value Added" or "EVA" of the
Company.  The purpose of the EVA Plan is to incent performance through bonus
payments that will promote the maximization of shareholder value over the long
term by linking performance

                                       21
<PAGE>
 
incentives to increases in shareholder value.  The EVA Plan ties bonus
compensation to EVA as described below, and thereby rewards employees for long-
term, sustained improvement in shareholder value.

     The Board of Directors has amended the EVA Plan and is now submitting it to
shareholders for approval.  The amended EVA Plan is substantially similar to the
current plan, but has been amended to maximize the tax deductibility of payments
made under the Plan under the Code.  If approved by the shareholders, the EVA
Plan will replace the current plan, effective January 1, 1999.  If the EVA Plan
is not approved by shareholders, the current plan will remain in effect.  Over
2,000 employees now participate in the EVA Plan.

     Shareholder approval of the EVA Plan is required so that payments made
under the Plan are fully tax deductible as "performed-based" compensation under
section 162 (m) of the Code.  As discussed on page 15 in the section entitled
"Deductibility Cap on Executive Compensation," section 162(m) disallows the
corporate tax deduction for certain compensation in excess of $1 million per
year paid to the Named Executive Officers.  However, certain compensation,
including compensation based on the attainment of performance goals, is excluded
from this deduction limit if the material terms of the plan are approved by the
Company's shareholders.

Purpose of the EVA Plan

     The purpose of the EVA Plan is to incent performance by linking bonuses to
improvements in the Company's EVA.  EVA reflects the benefits and costs of
capital employment for the Company.  Employees create economic value when the
operating profits from a business exceed the cost of the capital employed.  A
feature of the EVA Plan is that the bonus is at risk of non-payment if certain
performance goals are not met.  In fact, not only is there the possibility that
no bonus will be earned, but a portion of future bonus payments may be reduced
if specified performance goals are not met.

     The principal features of the EVA Plan are summarized below.  The EVA Plan
summary is qualified in its entirety by reference to the full text of the EVA
Plan, which is attached to this Proxy Statement as Exhibit B.

Principal Features of the EVA Plan

     The EVA Plan determines incentive compensation payments based upon the
actual performance of the Company in achieving improvement in EVA relative to
the established EVA targets.  Improvements in EVA occurs when the ratio of net
after-tax operating profit to capital employed in the business increases over
time.  It establishes a direct link between incentive compensation and return
earned on capital relative to a specified target return.  EVA is defined under
the EVA Plan as the after-tax operating earnings of the Company for a plan year
in excess of the "capital charge."  The "capital charge" is defined as the net
investment employed by the Company in operations and financing activities,
multiplied by the percentage calculated from the weighted average of the
Company's "cost of debt" and the "cost of equity" (each as defined in the EVA
Plan).  Prior to the beginning of the plan year, the Committee may specify that
EVA will be determined before the effects of acquisitions, divestitures,
restructuring or changes in corporate capitalization, accounting changes, and/or
events that are treated as extraordinary items for accounting purposes.

     The EVA Plan is administered by the Compensation and Management Development
Committee of the Board.  All employees of the Company and its subsidiaries are
eligible to participate in the EVA Plan, and the Committee will select from
among the eligible employees those who may participate for a particular plan
year.  The Committee will make target bonus awards to each participant in the
EVA Plan for a plan year, determined by the Committee according to a schedule
that associates job responsibilities with a target bonus amount expressed as a
percentage of the participant's annual base salary as in effect at the beginning
of the plan year.  Prior to the beginning of each year, the Committee will
approve a target level of EVA performance for all participants for the plan
year.  The target EVA for any plan year will be determined by adding (i) the
average of the prior year's actual EVA and the prior plan year's target EVA, and
(ii) an additional EVA amount determined by the Committee to insure a minimum
level of improvement in EVA.  The actual bonus earned by a participant under the
EVA Plan is determined by adjusting the participant's target bonus for the year
upwards or downwards depending upon whether the actual EVA surpasses or falls
short of the target EVA.  However, if actual EVA for any plan year falls below a
minimum acceptable level established by the Committee at the beginning of the
plan year, no bonuses will be earned by participants for that plan year and the
balance in the participant's bonus bank will be reduced.

                                       22
<PAGE>
 
     After a bonus award for a participant has been determined under the EVA
Plan for a plan year, it will be credited to the participant's "bonus bank." 
The amount of the bonus bank is increased or decreased for any plan year by the
amount of bonus determined for such year.  The Participant will be paid from his
bonus bank for such year up to the target bonus amount, plus one third of any
remaining bank balance for such year and prior plan years.  If the available
bonus bank balance is negative, no payment will occur.  The maximum amount of
the bonus that may be determined for a plan year and credited to a participant's
bonus bank is $5 million.  Special rules apply for the proration or forfeiture
of bonuses and amounts payable from the bonus bank upon termination of a
participant's employment under various circumstances (such as retirement, death,
disability or misconduct).  There are also special rules relating to leaves of
absence and demotions.

     The EVA Plan may be amended at any time by the Board or the Committee,
which may seek shareholder approval of any such amendment to the extent deemed
necessary or advisable for purposes of complying with Section 162(m) of the Code
or for any other reason.  The EVA Plan, if approved, will remain in effect until
December 31, 2003.

     It is not possible at this time to determine the bonuses that may become
payable under the EVA Plan for 1999, the first year of the amended plan's
operation. The EVA awards paid under the current EVA Plan in 1997 to the
Company's Named Executive Officers are as set forth on the Summary Compensation
Table on page 10. The aggregate EVA awards paid to all executive officers as a
group was $6,198,160 and approximately $57,188,811 for all non-executive
employees as a group.


The Board recommends that you vote FOR approving the amended EVA Bonus Plan.


     ITEM 5.  PROPOSAL TO RATIFY THE APPOINTMENT BY THE BOARD OF DIRECTORS
                       OF PRINCIPAL INDEPENDENT AUDITORS

     The Board of Directors, on the recommendation of the Audit Committee, has
appointed the firm of Ernst & Young LLP as principal independent auditors for
the Company for the year 1998.  In accordance with the By-laws of the Company,
this appointment will be submitted to the shareholders for ratification.  Ernst
& Young served as the principal independent auditors for the Company in 1997.
Representatives of Ernst & Young are expected to be present at the Annual
Meeting and will be available to respond to appropriate questions.  Those
representatives will have the opportunity to make a statement if they desire to
do so.


     The Board of Directors recommends that you vote FOR ratifying the
appointment of Ernst & Young LLP as principal independent auditors for the year
1998.

                                       23
<PAGE>
 
                                 OTHER MATTERS
                                        
Section 16(a) Beneficial Ownership Reporting Compliance
 
     Under Securities and Exchange Commission rules relating to reporting of
changes of beneficial ownership of Company common stock, reports during the last
fiscal year relating to the following transactions of executive officers of the
Company were not timely filed due to inadvertence: One report for Ms. Goss
pertaining to gifts of stock; one report for Mr. Hanson, a retired executive,
pertaining to a stock option exercise; two reports for Mr. Tobias relating to
sales of stock by a family trust for the benefit of his children; and two
reports for Dr. Watanabe pertaining to gifts of stock and a stock option
exercise, respectively. Upon discovery, all these oversights were promptly
corrected.

     The Company will pay all expenses in connection with solicitation of
proxies. The Company will pay brokers, nominees, fiduciaries, or other
custodians their reasonable expenses for sending proxy material to, and
obtaining instructions from, persons for whom they hold stock of the Company.
The Company expects to solicit proxies primarily by mail, but directors,
officers, and other employees of the Company may also solicit in person, by
telephone, by telefax, or by mail. The Company may retain D.F. King & Co., Inc.,
to assist in the distribution and solicitation of proxies. If retained, the firm
may solicit proxies by personal interview, telephone, telefax, and mail. It is
anticipated that the fee for those services will not exceed $18,000 plus
reimbursement of customary out-of-pocket expenses.

     As of the date of this Proxy Statement, the management of the Company does
not know of any matters to be presented for consideration at the meeting other
than those described in this Proxy Statement. If any other matters properly come
before the meeting, the accompanying proxy confers discretionary authority with
respect to those matters, and the persons named in the accompanying form of
proxy intend to vote that proxy to the extent entitled in accordance with their
best judgment.

 

                                  By order of the Board of Directors,


                                  Daniel P. Carmichael
                                  Secretary

March 4, 1998

                                      24
<PAGE>
 
                                     LOGO

Printed on Recycled and Recyclable Paper Using Soy-based (rather than petroleum-
                                   based) Ink
                                        
                                        

                                      25
<PAGE>
 
                                                                       Exhibit A

                                     1998

                               LILLY STOCK PLAN


    The 1998 Lilly Stock Plan ("1998 Plan") authorizes the Compensation and
Management Development Committee ("Committee") to provide officers and other
employees of Eli Lilly and Company and its subsidiaries with certain rights to
acquire shares of Eli Lilly and Company common stock ("Lilly Stock"). The
Company believes that this incentive program will benefit the Company's
shareholders by allowing the Company to attract, motivate, and retain employees
and by providing those employees stock-based incentives to contribute materially
to the growth and success of the Company. For purposes of the 1998 Plan, the
term "Company" shall mean Eli Lilly and Company and its subsidiaries, unless the
context requires otherwise.

1.  Administration.

    The 1998 Plan shall be administered and interpreted by the Committee
consisting of not less than two persons appointed by the Board of Directors of
the Company from among its members. A person may serve on the Committee only if
he or she (i) is a "Non-employee Director" for purposes of Rule 16b-3 under the
Securities Exchange Act of 1934, as amended (the "1934 Act"), and (ii) satisfies
the requirements of an "outside director" for purposes of Section 162(m) of the
Internal Revenue Code of 1986, as amended (the "Code"). The Committee shall
determine the fair market value of Lilly Stock for purposes of the 1998 Plan.
The Committee may, subject to the provisions of the 1998 Plan, from time to time
establish such rules and regulations and delegate such authority to administer
the 1998 Plan as it deems appropriate for the proper administration of the Plan,
except that no such delegation shall be made in the case of awards intended to
be qualified under Section 162(m) of the Code. The decisions of the Committee or
its authorized delegatees shall be final, conclusive, and binding with respect
to the interpretation and administration of the 1998 Plan and any Grant made
under it.

2.  Grants.

    Incentives under the 1998 Plan shall consist of incentive stock options or
other forms of tax-qualified stock options under the Code, nonqualified stock
options, performance awards, and restricted stock grants (collectively,
"Grants"). All Grants shall be subject to the terms and conditions set out
herein and to such other terms and conditions consistent with the 1998 Plan as
the Committee deems appropriate. The Committee shall approve the form and
provisions of each Grant. Grants under a particular section of the 1998 Plan
need not be uniform and Grants under two or more sections may be combined in one
instrument.

3.  Eligibility for Grants.

    Grants may be made to any employee of the Company, including a person who is
also a member of the Board of Directors ("Eligible Employee"). The Committee

<PAGE>
 
shall select the persons to receive Grants ("Grantees") from among the Eligible
Employees and determine the number of shares subject to any particular Grant.

4.  Shares Available for Grant.

    (a) Shares Subject to Issuance or Transfer.  Subject to adjustment as
provided in Section 4(b), the aggregate number of shares of Lilly Stock that may
be issued or transferred under the 1998 Plan is 55,000,000. The shares may be
authorized but unissued shares or treasury shares. The number of shares
available for Grants at any given time shall be 55,000,000, reduced by the
aggregate of all shares previously issued or transferred and of shares which may
become subject to issuance or transfer under then-outstanding Grants.

    (b) Adjustment Provisions.  If any subdivision or combination of shares of
Lilly Stock or any stock dividend, reorganization, recapitalization, or
consolidation or merger with Eli Lilly and Company as the surviving corporation
occurs, or if additional shares or new or different shares or other securities
of the Company or any other issuer are distributed with respect to the shares of
Lilly Stock through a spin-off or other extraordinary distribution, the
Committee shall make such adjustments as it determines appropriate in the number
of shares of Lilly Stock that may be issued or transferred in the future under
Sections 4(a), 5(f), 6(f), and 7(e). The Committee shall also adjust as it
determines appropriate the number of shares and Option Price in outstanding
Grants made before the event.

5.  Stock Options.

    The Committee may grant options qualifying as incentive stock options under
the Code ("Incentive Stock Options"), other forms of tax-favored stock options
under the Code, and nonqualified stock options (collectively, "Stock Options").
The following provisions are applicable to Stock Options:

     (a) Option Price.  The Committee shall determine the price or prices at
which Lilly Stock may be purchased by the Grantee under a Stock Option ("Option
Price") which shall be not less than the fair market value of Lilly Stock on the
date the Stock Option is granted (the "Grant Date"). In the Committee's
discretion, the Grant Date of a Stock Option may be established as the date on
which Committee action approving the Stock Option is taken or any later date
specified by the Committee. Once established, the Option Price may not be
changed except in the case of adjustments under Section 4(b).

     (b) Option Exercise Period.  The Committee shall determine the option
exercise period of each Stock Option. The period shall not exceed ten years from
the Grant Date.

     (c) Exercise of Option.  A Stock Option will be deemed exercised by a
Grantee upon delivery of (i) a notice of exercise to the Company or its
representative as designated by the Committee, and (ii) accompanying payment of
the Option Price if the Stock Option requires such payment at the time of
exercise. The notice of exercise, once delivered, shall be irrevocable.

     (d) Satisfaction of Option Price.  A Stock Option may require payment of
the Option Price upon exercise or may specify a period not to exceed 30 days
following


                                      -2-
<PAGE>
 
exercise within which payment must be made ("Payment Period"). The Grantee shall
pay or cause to be paid the Option Price in cash, or with the Committee's
permission, by delivering (or providing adequate evidence of ownership of)
shares of Lilly Stock already owned by the Grantee and having a fair market
value on the date of exercise equal to the Option Price, or a combination of
cash and such shares. If the Grantee fails to pay the Option Price within the
Payment Period, the Committee shall have the right to take whatever action it
deems appropriate, including voiding the option exercise or voiding that part of
the Stock Option for which payment was not timely received. The Company shall
not deliver shares of Lilly Stock upon exercise of a Stock Option until the
Option Price and any required withholding tax are fully paid.

     (e) Share Withholding.  With respect to any nonqualified option, the
Committee may, in its discretion and subject to such rules as the Committee may
adopt, permit or require the Grantee to satisfy, in whole or in part, any
withholding tax obligation which may arise in connection with the exercise of
the nonqualified option by having the Company withhold shares of Lilly Stock
having a fair market value equal to the amount of the withholding tax.

     (f) Limits on Individual Grants.  No individual Grantee may be granted
Stock Options under the 1998 Plan for more than 1,500,000 shares of Lilly Stock
in any period of three consecutive calendar years.

     (g) Limits on Incentive Stock Options.  The aggregate fair market value of
the stock covered by Incentive Stock Options granted under the 1998 Plan or any
other stock option plan of the Company or any subsidiary or parent of the
Company that become exercisable for the first time by any employee in any
calendar year shall not exceed $100,000. The aggregate fair market value will be
determined at the Grant Date. An Incentive Stock Option shall not be granted to
any Eligible Employee who, on the Grant Date, owns stock possessing more than
10% of the total combined voting power of all classes of stock of the Company or
any subsidiary or parent of the Company.

6.  Performance Awards.

     The Committee may grant Performance Awards which shall be denominated at
the time of grant either in shares of Lilly Stock ("Stock Performance Awards")
or in dollar amounts ("Dollar Performance Awards"). Payment under a Stock
Performance Award or a Dollar Performance Award shall be made, at the discretion
of the Committee, in shares of Lilly Stock ("Performance Shares"), or in cash or
in any combination thereof, if the financial performance of the Company or any
subsidiary, division, or other unit of the Company ("Business Unit") selected by
the Committee meets certain financial goals established by the Committee for the
Award Period. The following provisions are applicable to Performance Awards:

     (a) Award Period.  The Committee shall determine and include in the Grant
the period of time (which shall be four or more consecutive fiscal quarters) for
which a Performance Award is made ("Award Period"). Grants of Performance Awards
need not be uniform with respect to the length of the Award Period. Award
Periods for different Grants may overlap. A Performance Award may not be granted
for a given Award Period after one half (1/2) or more of such period has
elapsed, or in the case of an Award intended to be qualified under Section
162(m) of the Code, after 90 days or more of such period has elapsed.


                                      -3-
<PAGE>
 
     (b) Performance Goals and Payment.  Before a Grant is made, the Committee
shall establish objectives ("Performance Goals") that must be met by the
Business Unit during the Award Period as a condition to payment being made under
the Performance Award. The Performance Goals, which must be set out in the
Grant, are limited to earnings per share; divisional income; net income; return
on equity; economic value added (EVA); market value added (MVA); any of the
foregoing before the effect of acquisitions, divestitures, accounting changes,
and restructuring and special charges (determined according to criteria
established by the Committee at or within 90 days after the time of grant);
total shareholder return; or stock price goals. The Committee shall also set
forth in the Grant the number of Performance Shares or the amount of payment to
be made under a Performance Award if the Performance Goals are met or exceeded,
including the fixing of a maximum payment (subject to Section 6(f)).

     (c) Computation of Payment.  After an Award Period, the financial
performance of the Business Unit during the period shall be measured against the
Performance Goals. If the minimum Performance Goals are not met, no payment
shall be made under a Performance Award. If the minimum Performance Goals are
met or exceeded, prior to payment the Committee shall certify that fact in
writing and certify the number of Performance Shares or the amount of payment to
be made under a Performance Award in accordance with the grant for each Grantee.
The Committee, in its sole discretion, may elect to pay part or all of the
Performance Award in cash in lieu of issuing or transferring Performance Shares.
The cash payment shall be based on the fair market value of Lilly Stock on the
date of payment (subject to Section 6(f)). The Company shall promptly notify
each Grantee of the number of Performance Shares and the amount of cash, if any,
he or she is to receive.

     (d) Revisions for Significant Events.  At any time before payment is made,
the Committee may revise the Performance Goals and the computation of payment if
unusual events occur during an Award Period which have a substantial effect on
the Performance Goals and which in the judgment of the Committee make the
application of the Performance Goals unfair unless a revision is made; provided,
however, that no such revision shall be permissible with respect to a
Performance Award intended to qualify for exemption under Section 162 (m) of the
Code, except that the Committee (i) may provide in the terms of any such
Performance Award that revisions to the Performance Goals shall be made on a 
non-discretionary basis upon the occurrence of one or more specific objective
events, the occurrence of which are substantially uncertain at the time of
grant, and (ii) may in its discretion make a revision with respect to such
Performance Award that results in a lesser payment than would have occurred
without the revision or in no payment at all.

     (e) Requirement of Employment.  To be entitled to receive payment under a
Performance Award, a Grantee must remain in the employment of the Company to the
end of the Award Period, except that the Committee may provide for partial or
complete exceptions to this requirement as it deems equitable in its sole
discretion, consistent with maintaining the exemption under Section 162(m) of
the Code. The Committee may impose additional conditions on the Grantee's
entitlement to receive payment under a Performance Award.

     (f) Maximum Payments.  (i) No individual may receive Performance Award
payments in respect of Stock Performance Awards in excess of 100,000 shares of

                                      -4-
<PAGE>
 
Lilly Stock in any calendar year or payments in respect of Dollar Performance
Awards in excess of $4,000,000 in any calendar year. For purposes of determining
the maximum payment under this subsection, payment in cash of all or part of a
Stock Performance Award will be deemed an issuance of the number of shares with
respect to which such cash payment is made. No individual may receive both a
Stock Performance Award and a Dollar Performance Award for the same Award
Period.

     (ii) Not more than 18,000,000 shares of Lilly Stock may be issued or
transferred under the 1998 Plan in the form of Performance Awards.

7.  Restricted Stock Grants.

    The Committee may issue or transfer shares of Lilly Stock to a Grantee under
a Restricted Stock Grant. Upon the issuance or transfer, the Grantee shall be
entitled to vote the shares and to receive any dividends paid. The following
provisions are applicable to Restricted Stock Grants:

     (a) Requirement of Employment.  If the Grantee's employment terminates
during the period designated in the Grant as the "Restriction Period," the
Restricted Stock Grant terminates. However, the Committee may provide for
partial or complete exceptions to this requirement as it deems equitable.

     (b) Restrictions on Transfer.  During the Restriction Period, a Grantee may
not sell, assign, transfer, pledge, or otherwise dispose of the shares of Lilly
Stock except to a Successor Grantee under Section 10(a). Each certificate for
shares issued or transferred under a Restricted Stock Grant shall be held in
escrow by the Company until the expiration of the Restriction Period.

     (c) Withholding Tax.  Before delivering the certificate for shares of Lilly
Stock to the Grantee, Lilly may require the Grantee to pay to the Company any
required withholding tax. The Committee may, in its discretion and subject to
such rules as the Committee may adopt, permit or require the Grantee to satisfy,
in whole or in part, any withholding tax requirement by having the Company
withhold shares of Lilly Stock from the Grant having a fair market value equal
to the amount of the withholding tax. In the event the Grantee fails to pay the
withholding tax within the time period specified in the Grant, the Committee may
take whatever action it deems appropriate, including withholding or selling
sufficient shares from the Grant to pay the tax and assessing interest or late
fees to the Grantee.

     (d) Lapse of Restrictions.  All restrictions imposed under the Restricted
Stock Grant shall lapse (i) upon the expiration of the Restriction Period if all
conditions stated in Sections 7(a), (b) and (c) have been met or (ii) as
provided under Section 9(a)(ii). The Grantee shall then be entitled to delivery
of the certificate.

     (e) Total Number of Shares Granted.  Not more than 2,000,000 shares of
Lilly Stock may be issued or transferred under the 1998 Plan in the form of
Restricted Stock Grants.

8.  Amendment and Termination of the 1998 Plan.

                                      -5-
<PAGE>
 
     (a) Amendment.  The Company's Board of Directors may amend or terminate the
1998 Plan, but no amendment shall (i) allow the repricing of Stock Options; (ii)
allow the grant of Stock Options at an Option Price below the fair market value
of Lilly Stock on the Grant Date; (iii) increase the number of shares authorized
for issuance or transfer pursuant to Sections 4(a), 6(f)(ii), or 7(e); or (iv)
increase the maximum limitations on Grants imposed under Sections 5(f) or
6(f)(i), unless in any case such amendment receives approval of the shareholders
of the Company.

     (b) Termination of 1998 Plan.  The 1998 Plan shall terminate on the fifth
anniversary of its effective date unless terminated earlier by the Board.

     (c) Termination and Amendment of Outstanding Grants.  A termination or
amendment of the 1998 Plan that occurs after a Grant is made shall not result in
the termination or amendment of the Grant unless the Grantee consents or unless
the Committee acts under Section 10(e).  The termination of the 1998 Plan shall
not impair the power and authority of the Committee or its delegatees with
respect to outstanding Grants.  Whether or not the 1998 Plan has terminated, an
outstanding Grant may be terminated or amended under Section 10(e) or may be
amended (i) by agreement of the Company and the Grantee consistent with the 1998
Plan or (ii) by action of the Committee provided that the amendment is
consistent with the 1998 Plan and is found by the Committee not to impair the
rights of the Grantee under the Grant.

9.  Change in Control.

     (a) Effect on Grants.  Unless the Committee shall otherwise expressly
provide in the agreement relating to a Grant, upon the occurrence of a Change in
Control (as defined below):

     (i) In the case of Stock Options, each outstanding Stock Option that is not
then fully exercisable shall automatically become fully exercisable and shall
remain so for the period permitted in the agreement relating to the Grant;

     (ii) The Restriction Period on all outstanding Restricted Stock Grants
shall automatically expire and all restrictions imposed under such Restricted
Stock Grants shall immediately lapse; and

     (iii) Each Grantee of a Performance Award for an Award Period that has not
been completed at the time of the Change in Control shall be deemed to have
earned a minimum Performance Award equal to the product of (y) such Grantee's
maximum award opportunity for such Performance Award, and (z) a fraction, the
numerator of which is the number of full and partial months that have elapsed
since the beginning of such Award Period to the date on which the Change in
Control occurs, and the denominator of which is the total number of months in
such Award Period; provided, however, that nothing in this subsection shall
prejudice the right of the Grantee to receive a larger payment under such
Performance Award pursuant to the terms of the Award or under any other plan of
the Company.

     (b) Change in Control.  For purposes of the 1998 Plan, a Change in Control
shall mean the happening of any of the following events:

                                      -6-
<PAGE>
 
     (i) The acquisition by any "person," as that term is used in Sections 13(d)
and 14(d) of the 1934 Act (other than (w) the Company, (x) any subsidiary of the
Company, (y) any employee benefit plan or employee stock plan of the Company or
a subsidiary of the Company or any trustee or fiduciary with respect to any such
plan when acting in that capacity, or (z) Lilly Endowment, Inc.,) of "beneficial
ownership," as defined in Rule 13d-3 under the 1934 Act, directly or indirectly,
of 20% or more of the shares of the Company's capital stock the holders of which
have general voting power under ordinary circumstances to elect at least a
majority of the Board of Directors of the Company (or which would have such
voting power but for the application of the Indiana Control Share Statute)
("Voting Stock");

     (ii) the first day on which less than two-thirds of the total membership of
the Board of Directors of the Company shall be Continuing Directors (as that
term is defined in Article 13(f) of the Company's Articles of Incorporation);

     (iii) approval by the shareholders of the Company of a merger, share
exchange, or consolidation of the Company (a "Transaction"), other than a
Transaction which would result in the Voting Stock of the Company outstanding
immediately prior thereto continuing to represent (either by remaining
outstanding or by being converted into voting securities of the surviving
entity) more than 50% of the Voting Stock of the Company or such surviving
entity immediately after such Transaction; or

     (iv) approval by the shareholders of the Company of a complete liquidation
of the Company or a sale or disposition of all or substantially all the assets
of the Company.

10.  General Provisions.

     (a) Prohibitions Against Transfer.  (i) Except as provided in part (ii) of
this subparagraph, only a Grantee or his or her authorized legal representative
may exercise rights under a Grant.  Such persons may not transfer those rights.
The rights under a Grant may not be disposed of by transfer, alienation, pledge,
encumbrance, assignment, or any other means, whether voluntary, involuntary, or
by operation of law, and any such attempted disposition shall be void; provided,
however, that when a Grantee dies, the personal representative or other person
entitled under a Grant under the 1998 Plan to succeed to the rights of the
Grantee ("Successor Grantee") may exercise the rights.  A Successor Grantee must
furnish proof satisfactory to the Company of his or her right to receive the
Grant under the Grantee's will or under the applicable laws of descent and
distribution.

     (ii) Notwithstanding the foregoing, the Committee may, in its discretion
and subject to such limitations and conditions as the Committee deems
appropriate, grant non-qualified stock options on terms which permit the Grantee
to transfer all or part of the stock option, for estate or tax planning purposes
or for donative purposes, and without consideration, to a member of the
Grantee's immediate family (as defined by the Committee), a trust for the
exclusive benefit of such immediate family members, or a partnership,
corporation or limited liability company the equity interests of which are owned
exclusively by the Grantee and/or one or more members of his or her immediate
family.  No such stock option or any other Grant shall be transferable incident
to divorce.  Subsequent transfers of a stock option transferred under this part

                                      -7-
<PAGE>
 
(ii) shall be prohibited except for transfers to a Successor Grantee upon the
death of the transferee.

     (b) Substitute Grants.  The Committee may make a Grant to an employee of
another corporation who becomes an Eligible Employee by reason of a corporate
merger, consolidation, acquisition of stock or property, reorganization or
liquidation involving the Company in substitution for a stock option,
performance award, or restricted stock grant granted by such other corporation
("Substituted Stock Incentive").  The terms and conditions of the substitute
Grant may vary from the terms and conditions that would otherwise be required by
the 1998 Plan and from those of the Substituted Stock Incentives.  The Committee
shall prescribe the exact provisions of the substitute Grants, preserving where
practical the provisions of the Substituted Stock Incentives.  The Committee
shall also determine the number of shares of Lilly Stock to be taken into
account under Section 4.

     (c) Subsidiaries.  The term "subsidiary" means a corporation, limited
liability company or similar form of entity of which Eli Lilly and Company owns
directly or indirectly 50% or more of the voting power.

     (d) Fractional Shares.  Fractional shares shall not be issued or
transferred under a Grant, but the Committee may pay cash in lieu of a fraction
or round the fraction.

     (e) Compliance with Law.  The 1998 Plan, the exercise of Grants, and the
obligations of the Company to issue or transfer shares of Lilly Stock under
Grants shall be subject to all applicable laws and regulations and to approvals
by any governmental or regulatory agency as may be required.  The Committee may
revoke any Grant if it is contrary to law or modify a Grant to bring it into
compliance with any valid and mandatory law or government regulation.  The
Committee may also adopt rules regarding the withholding of taxes on payment to
Grantees.

     (f) Ownership of Stock.  A Grantee or Successor Grantee shall have no
rights as a shareholder of the Company with respect to any shares of Lilly Stock
covered by a Grant until the shares are issued or transferred to the Grantee or
Successor Grantee on the Company's books.

     (g) No Right to Employment or to Future Grants.  The 1998 Plan and the
Grants under it shall not confer upon any Grantee the right to continue in the
employment of the Company or affect in any way the right of the Company to
terminate the employment of a Grantee at any time, with or without notice or
cause.  The receipt of one or more Grants by a Grantee shall not confer upon the
Grantee any rights to future Grants.

     (h) Foreign Jurisdictions.  The Committee may adopt, amend, and terminate
such arrangements and make such Grants, not inconsistent with the intent of the
1998 Plan, as it may deem necessary or desirable to make available tax or other
benefits of the laws of foreign jurisdictions to Grantees who are subject to
such laws.  The terms and conditions of such foreign Grants may vary from the
terms and conditions that would otherwise be required by the 1998 Plan.

     (i) Governing Law.  The 1998 Plan and all Grants made under it shall be
governed by and interpreted in accordance with the laws of the State of Indiana,

                                      -8-
<PAGE>
 
regardless of the laws that might otherwise govern under applicable Indiana
conflict-of-laws principles.

     (j) Effective Date of the 1998 Plan.  The 1998 Plan shall become effective
upon its approval by the Company's shareholders at the annual meeting to be held
on April 20, 1998, or any adjournment of the meeting.

                                     * * *


                                      -9-
<PAGE>
 
                     Eli Lilly and Company EVA Bonus Plan
                                        
              (As amended and restated effective January 1, 1998)

<PAGE>
 
                                   ARTICLE I
                                   ---------

                  Bonus Plan Statement of Purpose and Summary
                  -------------------------------------------

1.1  The purpose of the Plan is to provide a system of bonus compensation for
     selected employees of Eli Lilly and Company and subsidiaries which will
     promote the maximization of shareholder value over the long term, by
     linking performance incentives to increases in shareholder value. The Plan
     ties bonus compensation to Economic Value Added ("EVA"), and thereby
     rewards employees for long-term, sustained improvement in shareholder
     value.

1.2  EVA will be used as the performance measure of value creation. EVA reflects
     the benefits and costs of capital employment. Employees create economic
     value when the operating profits from a business exceed the cost of the
     capital employed.

                                  ARTICLE II
                                  ----------


                         Definitions of Certain Terms
                         ----------------------------

Unless the context requires a different meaning, the following terms shall have
the following meanings:

2.1  "Company" means Eli Lilly and Company and its subsidiaries.

2.2  "Committee" means the Compensation and Management Development Committee,
     the members of which shall be selected by the Board of Directors from among
     its members.

2.3  "Participant" means any employee of the Company designated by the Committee
     as a participant in the Plan with respect to any Plan Year. In its
     discretion, the Committee may designate Participants either on an
     individual basis or by determining that all employees in specified job
     categories, classification or levels shall be Participants.

2.4  "Plan" means this Eli Lilly and Company EVA Bonus Plan.

2.5  "Plan Year" means the applicable calendar year.

2.6  "Retirement" means the cessation of employment upon the attainment of at
     least eighty age and service points, as determined by the provisions of The
     Lilly Retirement Plan as amended from time to time, assuming eligibility to
     participate in that plan.

2.7  "Disability" means the time at which a Participant becomes eligible for a
     payment under The Lilly Extended Disability Plan, assuming eligibility to
     participate in that plan.
<PAGE>
 
                                  ARTICLE III
                                  -----------

                       Definition and Components of EVA
                       --------------------------------

The following terms set forth the calculation of EVA and the components of
calculating EVA. The calculation of EVA for a Plan Year is used in determining
the bonuses earned by Participants under the Plan, as set forth in Article IV.

3.1  "Economic Value Added" or "EVA" means the excess NOPAT that remains after
     subtracting the Capital Charge.

3.2  "Net Operating Profit After Tax" or "NOPAT" means the after tax operating
     earnings of the Company for the Plan Year. NOPAT is determined by adding
     net sales plus other net income (excluding interest income from operating
     cash) and subtracting the following: cost of goods sold, selling, general
     and administrative expenses (excluding goodwill amortization and interest
     expense), amortization of research and development, taxes (excluding the
     tax benefit of interest expense) and amounts associated with discontinued
     operations.

3.3  "Capital Charge" means the deemed opportunity cost of employing Capital for
     the Company. The Capital Charge is calculated by multiplying Capital times
     Cost of Capital (C*).

3.4  "Capital" means the net investment employed in the operations of the
     Company produced by operations and financing activities. Capital is
     calculated by adding together current assets (excluding operating cash),
     net property, plant and equipment, gross goodwill, net intangibles, other
     assets, and capitalized research and development, and the present value of
     operating leases, and subtracting the following: non-interest bearing
     liabilities and capital associated with discontinued operations.

3.5  "Cost of Capital" or "C*" is the percentage calculated from the weighted
     average of Cost of Debt and Cost of Equity. Cost of Capital for each Plan
     Year is determined by reference to the percentage calculated at the end of
     October of the prior Plan Year.

3.6  "Cost of Debt" capital is the marginal long-term borrowing rate of the
     Company times (one minus the tax rate).

3.7  "Cost of Equity" capital is the risk-free rate plus (beta times the market
     risk premium). For this purpose, (i) "risk free rate" is the 30-year U.S.
     Treasury Bond rate, (ii) "beta" represents the 5 year historical average
     variation of the Company's earnings versus the S&P 500, and (iii) "market
     risk premium" represents the average risk of an equity return versus a bond
     return.
 
<PAGE>
 
                                   ARTICLE IV

                  Definition and Computation of the EVA Bonus

Bonuses earned under the Plan for a Plan Year are determined based on a
comparison of actual EVA to the "Target EVA" for the year, which is established
as described below to ensure improvement in EVA from year to year.  The result
of this comparison is adjusted by a "Leverage Factor" measuring the volatility
of industry returns.  The factor produced is referred to as the "Bonus
Multiple," which is multiplied by the Participant's "Target Bonus" amount
established for the year to produce the actual bonus earned.  This amount,
referred to as the "Declared Bonus," is credited to the Participant's "Bonus
Bank" balance and paid out in the manner provided below.

4.1  Target Bonus.  The Target Bonus Awards will be determined by the Committee
     on a basis that takes into consideration a Participant's salary grade
     level, job responsibilities, as well as past and expected future job
     performance.  Target Bonus Awards are expressed as a percentage of annual
     base salary as in effect on the first day of the Plan Year.  If a
     Participant moves from any salary grade level to a G-6 or above salary
     grade level during a Plan Year, he/she will receive an award that is pro-
     rated according to time based on the Target Bonus percentage and base
     salary applicable to each such salary grade.  The Target Bonus will be
     based on the currency in which the highest portion of base pay is regularly
     paid.  The Committee shall determine the appropriate foreign exchange
     conversion methodology in its discretion.

4.2  Declared Bonus.  A Declared Bonus is the Target Bonus times the Bonus
     Multiple.

4.3  Bonus Multiple.  The Bonus Multiple is the difference (positive or
     negative) between Actual EVA and Target EVA, divided by the Leverage
     Factor, plus one.

4.4  Bonus Bank.  All bonus payments are made from the Bonus Bank.  Each
     Participant's beginning Bonus Bank balance in his/her first year of
     participation is zero.  The Bonus Bank is increased or decreased for any
     plan year by the amount of Declared Bonus.  If the available Bonus Bank
     balance is positive, the Participant will be paid from such balance up to
     the Target Bonus amount, plus one third of any such balance that remains
     after subtracting the Target Bonus from available Bonus Bank balance.  If
     the available Bonus Bank balance is negative, no payment will occur.

4.5  Target EVA. The Target EVA for each year will be calculated as follows:
<TABLE>
<CAPTION>

<S>                                                                      <C>
     Target EVA = [Prior Year's Actual EVA + Prior Year's Target EVA] +  Expected
                   -------------------------------------------------    Improvement
                                           2
</TABLE>
4.6  Expected Improvement.  The Expected Improvement is the additional EVA
     amount determined by the Committee that is used to assure that a minimum
     level of improvement is achieved in order to earn target awards.

                                       3
<PAGE>
 
4.7  Leverage Factor.  The Leverage Factor determines the rate of change in
     bonuses as EVA surpasses or falls short of Target EVA, determined by the
     Committee from an evaluation of the long term volatility of industry
     returns.

4.8  Working Plan Example.  Examples of the mechanics of the Plan are shown on
     Schedule A.

                                   ARTICLE V

                              Plan Administration

5.1  Time of Payment.  Payment from the Bonus Bank will be made before March 1
     of the year following the Plan Year.

5.2  Certification of Results.  Before any amount is paid under the Plan, the
     Committee shall certify in writing the calculation of EVA for the Plan Year
     and the satisfaction of all other material terms of the calculation of the
     Declared Bonus.

5.3  New Hires, Promotions.  New hires or individuals promoted who are first
     selected for participation by the Committee effective on a date other than
     January 1 will participate on a pro-rata basis in their first year of
     participation, based on the Declared Bonus determined for the Plan Year,
     pro-rated for that period of the year during which the Participant was
     selected for participation in the Plan.  Any such Participant's Target
     Bonus Award will be determined based on his or her annual base salary as in
     effect on the date of hire or promotion, as applicable.

5.4  Termination of Employment, Demotions.  If a Participant ceases employment
     with the Company before the end of a Plan Year for reasons other than
     Retirement, Disability or death, or is demoted to a non-global job level
     with the Company during a Plan Year, the Participant shall receive no
     Declared Bonus for that Plan Year, and his/her Bank Balance shall be
     forfeited.  The Committee may make complete or partial exceptions to this
     rule, in its sole discretion.

5.5  Leave of Absence.  If a Participant takes an approved leave of absence from
     employment during a Plan Year, the Participant will not be eligible for the
     Declared Bonus for the Plan Year.  The Committee may make complete or
     partial exceptions to this rule, in whatever manner it deems appropriate.
     The Participant will retain his Bonus Bank balance if he returns to
     employment following the period of leave of absence.

5.6  Retirement, Disability or Death.  If a Participant ceases employment with
     the Company because of Retirement, Disability or death, the Participant or
     personal representative, as the case may be, shall receive full payment of
     his/her Bank Balance and a bonus based on the Declared Bonus determined for
     the Plan Year but pro-rated for that period of the year during which the
     Participant was an active employee of the Company.


                                       4
<PAGE>
 
5.7  Plan Participation.  A Participant may not participate in this Plan for any
     portion of a year for which he/she is entitled to receive payment under the
     Eli Lilly and Company Contingent Compensation Plan, and shall be treated in
     accordance with 5.3.

5.8  Forfeiture Events.  Notwithstanding any other provision of this Plan to the
     contrary, the Committee may, in its sole discretion, upon the occurrence of
     a Forfeiture Event (as defined below), forfeit all or any portion of a
     Participant's Declared Bonus and Bonus Bank balance and terminate such
     Participant's future participation in the Plan.  For purposes hereof, a
     "Forfeiture Event" shall mean the occurrence of one or more of the
     following events with respect to a Participant: (i)  the termination or
     forced resignation from employment of the Participant for "misconduct" (as
     defined in the Company's Employee Information Hardbook), (ii) any violation
     by the Participant of the Guidelines of Company Policy (the "Redbook") that
     is detrimental to the Company, (iii) any breach of a noncompetition,
     nonsolicitation, nondisclosure or other restrictive covenant that may apply
     by written agreement between the Company and the Participant or (iv)
     Participant's having engaged in any other activity that, in the judgement
     of the committee, is detrimental to the business, affairs or reputation of
     the Company (including, without limitation, engaging in any criminal
     activity).

                                   ARTICLE VI

                               General Provisions
                               
6.1  Withholding of Taxes.  The Company shall have the right to withhold the
     amount of taxes which in the sole determination of the Company are required
     to be withheld under law with respect to any amount due or payable under
     the Plan.

6.2  Expenses.  All expenses and costs in connection with the adoption and
     administration of the plan shall be borne by the Company.

6.3  No Prior Right or Offer, No Right to Future Participation.  Participation
     in the Plan for Plan Years is determined from year-to-year by the Committee
     in its sole discretion.  Except and until expressly granted pursuant to the
     Plan, nothing in the Plan shall be deemed to give any employee any
     contractual or other right to participate in the benefits of the Plan.  No
     award to any such Participant in any Plan Year shall be deemed to create a
     right to receive any award or to participate in the benefits of the Plan in
     any subsequent Plan Year.

6.4  Rights Personal to Employee.  Any rights provided to an employee under the
     Plan shall be personal to such employee, shall not be transferable, except
     by will or pursuant to the laws of descent or distribution, and shall be
     exercisable during his/her lifetime, only by such employee, or a court-
     appointed guardian for the employee.

6.5  Non-Allocation of Award.  In the event of a suspension of the Plan in any
     Plan Year, as described in Section 11.1, no awards under the Plan for the
     Plan Year during which such 


                                       5
<PAGE>
 
     suspension occurs shall affect the calculation of awards for any
     subsequent period in which the Plan is continued.

                                  ARTICLE VII

                                  Limitations

7.1  No Continued Employment.  Neither the establishment of the Plan nor the
     grant of an award thereunder shall be deemed to constitute an express or
     implied contract of employment of any Participant for any period of time or
     in any way abridge the rights of the Company to determine the terms and
     conditions of employment or to terminate the employment of any employee
     with or without notice or cause at any time.

7.2  No Vested Rights.  Except as expressly provided herein, no employee or
     other person shall have any claim of right (legal, equitable, or otherwise)
     to any award, allocation, or distribution or any right, title, or vested
     interest in any amounts in his/her Bonus Bank and no officer or employee of
     the Company or any other person shall have any authority to make
     representations or agreements to the contrary.  No interest conferred
     herein to a Participant shall be assignable or subject to claim by a
     Participant's creditors.

7.3  Non-alienation.  Except as provided in Subsection 5.1, no Participant or
     other person shall have any right or power, by draft, assignment, or
     otherwise, to mortgage, pledge or otherwise encumber in advance any payment
     under the Plan, and every attempted draft, assignment, or other disposition
     thereof shall be absolutely void.

                                  ARTICLE VIII

                              Committee Authority

8.1  Authority to Interpret and Administer.  Except as otherwise expressly
     provided herein, full power and authority to interpret and administer this
     Plan shall be vested in the Committee.  The Committee may from time to time
     make such decisions and adopt such rules and regulations for implementing
     the Plan as it deems appropriate for any Participant under the Plan.
     Except as to Participants who are treated by the Company as executive
     officers of the Company for federal securities law reporting purposes, the
     Committee may delegate in writing to officers or employees of the Company
     the power and authority granted by this Section 8.1 to interpret and
     administer this Plan.  Any decision taken by the Committee or officer or
     employee to whom authority has been delegated, arising out of or in
     connection with the construction, administration, interpretation and effect
     of the Plan shall be final, conclusive and binding upon all Participants
     and any person claiming under or through Participants.

8.2  Committee Discretion to Revise Rates and Amounts.  The committee may, in
     its sole discretion, revise the various rates, amounts and percentages
     provided in the Plan from 


                                       6
<PAGE>
 
      time to time (including, without limitation, with respect to each of the
      foregoing defined terms), provided that the methods and assumptions used
      in making such determinations shall be established and applied by the
      Committee on the basis of reasonable, objective criteria that are applied
      in a uniform manner from Plan Year to Plan Year.

8.3   Financial And Accounting Terms. Except as otherwise provided, financial
      and accounting terms, including terms defined herein, shall be determined
      by the Committee in accordance with generally accepted accounting
      principles and as derived from the audited consolidated financial
      statements of the Company, prepared in the ordinary course of business.

                                  ARTICLE IX
                                  ----------

                                    Notice
                                    ------

9.1   Any notice to be given to the Company or Committee pursuant to the
      provisions of the Plan shall be in writing and directed to Secretary, Eli
      Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.

                                   ARTICLE X
                                   ---------

                                Effective Date
                                --------------

10.1  This Plan shall be effective as of January 1, 1995, as amended and
      effective January 1, 1998.

                                  ARTICLE XI
                                  ----------

                          Amendments and Termination
                          --------------------------

11.1  This Plan may be amended, suspended or terminated at any time at the
      discretion of the Board of Directors of Eli Lilly and Company, and may,
      except for this Section 11.1, be amended at any time by the Committee.

                                  ARTICLE XII
                                  -----------

                                Applicable Law
                                --------------

12.1  This Plan shall be governed by and construed in accordance with the
      provisions of the laws of the State of Indiana.
<PAGE>

PROXY 
                             ELI LILLY AND COMPANY

The undersigned hereby appoints Ms. R.O. Goss, and Messrs S. Taurel and R.L.
Tobias, and each of them, as proxies of the undersigned, each with power to act
without the others and with full power of substitution, to vote all the shares
of common stock of ELI LILLY AND COMPANY held in the name of the undersigned at
the close of business on February 13, 1998, at the Annual Meeting of
Shareholders to be held on April 20, 1998, at 11:00 a.m. (Indianapolis time),
and at any adjournment thereof, with all the powers the undersigned would have
if personally present as follows:

     .  The Board of Directors recommends a vote FOR the following items.

(1)  Election of Directors, each for a three year term

     Nominees:
     Dr. S.C. Beering
     Dr. F.G. Prendergast       FOR [_]                 WITHHOLD [_]
     Mrs. K.P. Seifert                                  AUTHORITY
     Mr. R.L. Tobias            All nominees            To vote for
                                except as               all nominees
                                listed below

     INSTRUCTION:  To withhold authority to vote for any individual nominee 
                   write that nominee's name on the line below

                   ------------------------------------------------

(2)  Approval of amendment to Articles of Incorporation

          FOR  [_]              AGAINST  [_]            ABSTAIN  [_]

(3)  Approval of the 1998 Lilly Stock Plan

          FOR  [_]              AGAINST  [_]            ABSTAIN  [_]

(4)  Approval of the Eli Lilly and Company EVA Bonus Plan

          FOR  [_]              AGAINST  [_]            ABSTAIN  [_]

(5)  Ratification of the appointment by the Board of Directors of Ernst & Young
     LLP as principal independent auditors for 1998

          FOR  [_]              AGAINST  [_]            ABSTAIN  [_]

     Please sign exactly as names appear hereon.  Joint owners should each sign.
     When signing as attorney, executor, administrator, trustee or guardian, 
     please give full title as such.
                                                                 -----------
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                            . Fold and Detach here.



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