SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D/A
Amendment #1
Under the Securities Exchange Act of 1934
TRANSKARYOTIC THERAPIES, INC.
----------------------------
(Name of Issuer)
Common Stock par value $.01 per share
- ---------------------------------------------------------------------------
(Title of Class of Securities)
893735 10 0
-----------------
(CUSIP Number)
William K. Hoskins, Esq. Harry R. Benz
General Counsel Hoechst Corporation
Hoechst Marion Roussel, Inc. Route 202-206
10236 Marion Park Drive P.O. Box 2500
Kansas City, Missouri 64137-1405 Somerville, NJ 08876-1258
(816) 966-4000 (517) 636-1000
- ---------------------------------------------------------------------------
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
October 22, 1996
-------------------------------------------------------
(Date of Event Which Requires Filing of This Statement)
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(4)(i)(A) or (B), check the
following box. [ ]
Check the following box if a fee is being paid with this statement [ ].
Page 1 of 11
Exhibit Index is at Page 7
<PAGE> 2
CUSIP No. 893735 10 0
___________________________________________________________________________
1) Name of Reporting Person and its Hoechst Marion Roussel, Inc.
I.R.S. Identification Number 44-0565557
___________________________________________________________________________
2) Check the Appropriate Box if (a)[ ]
a Member of a Group (b)[ X ]
___________________________________________________________________________
3) SEC Use Only
___________________________________________________________________________
4) Source of Funds WC
___________________________________________________________________________
5) Check Box if Disclosure of Legal [ ]
Proceedings is Required Pursuant
to Items 2(d) or 2(e)
___________________________________________________________________________
6) Citizenship or Place of Organization Delaware
___________________________________________________________________________
7) Sole Voting Power 2,187,408
Number of ____________________________________________________________
Shares
Beneficially 8) Shared Voting Power 0
Owned by ____________________________________________________________
Each
Reporting 9) Sole Dispositive Power 2,187,408
Person With ____________________________________________________________
10) Shared Dispositive Power 0
___________________________________________________________________________
11) Aggregate Amount Beneficially Owned 2,187,408
by Each Reporting Person
___________________________________________________________________________
12) Check Box If the Aggregate Amount [ ]
in Row (11) Excludes Certain Shares
___________________________________________________________________________
13) Percent of Class Represented 13.2%
by Amount in Row (11)
___________________________________________________________________________
14) Type of Reporting Person CO
___________________________________________________________________________
<PAGE> 3
CUSIP No. 893735 10 0
___________________________________________________________________________
1) Name of Reporting Person and its Hoechst Corporation
I.R.S. Identification Number 22-1862783
___________________________________________________________________________
2) Check the Appropriate Box if (a)[ ]
a Member of a Group (b)[ X ]
___________________________________________________________________________
3) SEC Use Only
___________________________________________________________________________
4) Source of Funds Not applicable
___________________________________________________________________________
5) Check Box if Disclosure of Legal [ ]
Proceedings is Required Pursuant
to Items 2(d) or 2(e)
___________________________________________________________________________
6) Citizenship or Place of Organization Delaware
___________________________________________________________________________
7) Sole Voting Power 2,187,408
Number of ____________________________________________________________
Shares
Beneficially 8) Shared Voting Power 0
Owned by ____________________________________________________________
Each
Reporting 9) Sole Dispositive Power 2,187,408
Person With ____________________________________________________________
10) Shared Dispositive Power 0
___________________________________________________________________________
11) Aggregate Amount Beneficially Owned 2,187,408
by Each Reporting Person
___________________________________________________________________________
12) Check Box If the Aggregate Amount [ ]
in Row (11) Excludes Certain Shares
___________________________________________________________________________
13) Percent of Class Represented 13.2%
by Amount in Row (11)
___________________________________________________________________________
14) Type of Reporting Person CO
___________________________________________________________________________
<PAGE> 4
This Amendment to the Statement on Schedule 13D (the "Schedule 13D")
with respect to the Common Stock of Transkaryotic Therapies, Inc. (the
"Issuer"), of Hoechst Marion Roussel, Inc., a Delaware corporation
("HMRI"), and Hoechst Corporation, a Delaware corporation ("HCorp"), is
filed solely to incorporate the following exhibits:
ITEM 7. MATERIAL TO BE FILED AS EXHIBITS.
- ------- ---------------------------------
I Information concerning directors and executive officers of HMRI.
J Information concerning directors and executive officers of HCorp
and Hoechst AG.
<PAGE> 5
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.
HOECHST MARION ROUSSEL, INC.
Date: November 12, 1996 By: /s/ William K. Hoskins
William K. Hoskins
Vice President,
General Counsel, and
Corporate Secretary
<PAGE> 6
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.
HOECHST CORPORATION
Date: November 12, 1996 By: /s/ David A. Jenkins
David A. Jenkins
Vice President, General
Counsel and Secretary
<PAGE> 7
EXHIBIT INDEX
Exhibit No. Description Page No.
- ----------- ------------ ---------
I Information concerning directors and 8
executive officers of HMRI.
J Information concerning directors and 9
executive officers of HCorp and Hoechst AG.
<PAGE> 8
Exhibit I
Directors and Officers of Hoechst Marion Roussel, Inc.
The following sets forth the name, title, business address, and
present principal occupation of each of the directors and executive
officers of HMRI as of June 1, 1996. All are citizens of the United States
unless otherwise indicated in parentheses under his or her name.
Name Title Address
- ---- ----- -------
Peter W. Ladell President and Chief 10236 Marion Park Drive
(Canada) Executive Officer Kansas City, MO 64137
and Director of HMRI
Alban W. Schuele Director of HMRI Hoechst AG
65926 Frankfurt Main
Germany
James P. Mitchum Vice President and 10236 Marion Park Drive
Chief Financial Kansas City, MO 64137
Officer
Kevin M. Hartley Vice President and 10236 Marion Park Drive
Treasurer Kansas City, MO 64137
Richard J. Markham Deputy Head of the Hoechst AG
Pharmaceutical Division 56926 Frankfurt Main
of Hoechst AG and Germany
Director of HMRI
Jean-Pierre Godard Head of the Pharma- Hoechst AG
(France) ceuticals Division of 65926 Frankfurt Main
Hoechst AG and President Germany
of the Board of Roussel
Uclaf; Director of HMRI
Horst Waesche Member of the Board of Hoechst AG
(Germany) Management; Pharmaceuti- 65926 Frankfurt Main
cal and Diagnostics Germany
Divisions; Schwarzkopf
of Hoechst AG
and Director of HMRI
Tommy R. White Vice President, Human 10236 Marion Park Drive
Resources and Corporate Kansas City, MO 64137
Relations
Kirk R. Schueler Vice President, U. S. 10236 Marion Park Drive
Commercial Director Kansas City, MO 64137
Charles A. Portwood Vice President, 10236 Marion Park Drive
Operations Kansas City, MO 64137
William K. Hoskins Vice President, 10236 Marion Park Drive
General Counsel and Kansas City, MO 64137
Corporate Secretary
<PAGE> 9
EXHIBIT J
CERTAIN INFORMATION RELATING
TO DIRECTORS AND EXECUTIVE OFFICERS
1. Directors and Executive Officers of Hoechst AG.
-----------------------------------------------
The following table sets forth the name, business address, present
principal occupation or employment of each member of the Supervisory Board
and the Board of Management (substantially the same as directors and
executive officers) of Hoechst AG. All of the members of the Supervisory
Board and the Board of Management are citizens of Germany except for
Messrs. Buhamrah, Drew, Furgler and Sonder who are citizens of Kuwait, the
United States, Switzerland and Brazil respectively. Unless otherwise
indicated, the business address of each of the individuals named below is
Hoechst AG, 65926 Frankfurt Main, Germany, and each occupation set forth
opposite the individual's name refers to employment with Hoechst AG.
Name and Business Address Principal Present Occupation
- ------------------------- ----------------------------
SUPERVISORY BOARD
Prof. Dr. rer. nat. Honorary Chairman of the Supervisory Board
Dr. h.c. mult
Rolf Sammet
Erhard Bouillon Chairman of the Supervisory Board
Arnold Weber Deputy Chairman of the Supervisory Board;
Chemical & textile laboratory technician;
Chairman of the Central Works Council and the
Group Works Council of Hoechst AG
Dr.-Ing. E.h. Member of the Supervisory Board
Willi Esser Mechanic; Member of the Central Works Council
of Hoechst AG
Dietrich-Kurt Frowein Member of the Board of Management of
Commerzbank AG
Dr. jur. Dr. h.c. mult. Member of the Supervisory Board
Kurt Furgler
Prof. Dr. rer. nat. Member of the Supervisory Board
Dr.-Ing. E.h.
Heinz Harnisch
Juergen Hilger Computer specialist, Member of the Central
Works Council and the Group Works Council of
Hoechst AG
Dr. rer. nat. Graduate Chemist; Chairman of
Ingolf Hornke the Senior Executives' Committee of
Hoechst AG
<PAGE> 10
Khaled. Saleh Buhamrah Chairman & Managing Director of Petrochemical
Industries Co., Kuwait
Hermann-Heinz Konrad Graduate Engineer; Deputy Chairman of the
Senior Executives' Committee of Hoechst AG
Rainer Kumlehn Electrician; Regional Head of the IG Chemie-
Papier-Keramik Hessen
Prof. Dr. rer. nat. President, Max-Planck-Gesellschaft, Munich
Dr. rer. nat. h.c.
Hubert Markl
Juergen Sarrazin Chairman of the Board of Managing Directors
of Dresdner Bank AG
Egon Schaefer Electrician; Deputy Chairman of IG Chemie-
Papier-Keramik
Dr. jur. Chairman of the Board of Management of
Hans-Juergen Schinzler Muenchner Rueckversicherungs-Gesellschaft
Konrad Starnecker Skilled Chemical Plant Operative; Member of
the Central Works Council of Hoechst AG
Wolfgang Vetter Fitter; Member of the Central Works
Council of Hoechst AG
Kurt F. Viermetz Vice Chairman of J.P. Morgan & Co. Inc.
Adam Wegehingel Machinist; Member of the Council of the
Gersthofen of Hoechst AG
BOARD OF MANAGEMENT
- -------------------
Juergen Dormann Chairman of the Board of Management
Dr. Ernest H. Drew, Ph.D. Member of the Board of Management; Chemicals,
Specialty Chemicals, Technical Polymers
Divisions
Prof. Dr. rer. nat. Member of the Board of Management;
Utz-Hellmuth Felcht Director of Personnel; Research; Herberts,
SGL Carbon, Hoechst CeramTec
Dipl. -Kfm. Member of the Board of Management;
Justus Mische Europe, Africa; Materials Management
Dr. -Ing. Member of the Board of Management; Messer
Ernst Schadow Griesheim, Uhde; Engineering and
Environmental Protection; Hoechst Site
Dr. Klaus J. Schmieder Member of the Board of Management
Dr. rer. nat. Member of the Board of Management;
Karl-Gerhard Seifert Pharmaceutical and Diagnostics Divisions;
Schwarzkopf
<PAGE> 11
Claudio Sonder Member of the Board of Management; Member of
the Supervisory Board of Hoechst Schering
AgrEvo GmbH; and Chairman of the Supervisory
Board of Hoechst do Brasil, San Paulo
Dipl.-Ing. Member of the Board of Management; Asia;
Horst Waesche AgrEvo; Hoechst Veterinar; Informatics and
Communication
2. Directors and Executive Officers of Hoechst Corporation.
--------------------------------------------------------
The following table sets forth the name and present principal
occupation or employment of each director and executive officer of Hoechst
Corporation. All such directors and officers are citizens of the United
States, except Mr. Schmieder who is a citizen of Germany. The business
address of Messrs. Benz, Jenkins, Premdas and Smedley is Hoechst Celanese
Corporation ("HCC"), Route 202-206, P.O. Box 2500, Somerville, New Jersey
08876-1258, and the business address of Messrs. Drew, Schmieder and Schuele
is Hoechst AG, 65926 Frankfurt Main, Germany.
Name/Position with Parent Principal Present Occupation
- ------------------------- ----------------------------
Harry R. Benz Senior Vice President - Finance,
Senior Vice President - Chief Financial Officer and Director - HCC
Finance, Chief Financial
Officer and Director
Dr. Ernest H. Drew, Ph.D. See "Directors and Executive Officers of
Chairman of the Board, Hoechst AG"
CEO & President and
Director
David A. Jenkins Vice President and General Counsel and
Vice President and General Director - HCC
Counsel and Director
Perry W. Premdas Vice President and Treasurer - HCC
Vice President and
Treasurer
Dr. Klaus J. Schmieder See "Directors and Executive Officer of
Director Hoechst AG"
Alban W. Schuele See "Directors and Officers of Hoechst Marion
Vice President and Roussel, Inc."
Director
Raymond W. Smedley Vice President and Controller - HCC
Vice President
and Controller
