HOECHST MARION ROUSSEL INC
SC 13G, 1998-03-31
PHARMACEUTICAL PREPARATIONS
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===========================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                                  SCHEDULE 13G
                                        


                   Under the Securities Exchange Act of 1934
                                        

                                             

                        


                          ARIAD PHARMACEUTICALS, INC.
                          ----------------------------
                                (Name of Issuer)



                         COMMON STOCK, $.001 PAR VALUE
- ---------------------------------------------------------------------------
                         (Title of Class of Securities)










                                  04033A 10 0
                               -----------------
                                 (CUSIP Number)

     *The remainder of this cover page shall be filled out for a reporting
person s initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which
would later the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not
be deemed to be  filed  for the purpose of Section 18 of the Securities
Exchange Act of 1934 ( Act ) or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of the
Act (however, see the Notes).

                       (Continued on following page(s))
===========================================================================
                                 Page 1 of 9

                      Exhibit Index is located at page 8



<PAGE>                                                                2
CUSIP No.  04033A 10 0
___________________________________________________________________________

1)   Name of Reporting Person and its         Hoechst Marion Roussel, Inc.
     I.R.S. Identification Number             44-0565557
___________________________________________________________________________

2)   Check the Appropriate Box if                                  (a)[   ]
     a Member of a Group                                           (b)[   ]
___________________________________________________________________________

3)   SEC Use Only
___________________________________________________________________________

4)   Citizenship or Place of Organization                         Delaware
___________________________________________________________________________
     
               5)   Sole Voting Power                            2,526,316
Number of      ____________________________________________________________
Shares
Beneficially   6)   Shared Voting Power                                  0
Owned by       ____________________________________________________________
Each
Reporting      7)   Sole Dispositive Power                       2,526,316
Person With    ____________________________________________________________

               8)   Shared Dispositive Power                             0
___________________________________________________________________________

 9)  Aggregate Amount Beneficially Owned                         2,526,316
     by Each Reporting Person
___________________________________________________________________________

10)  Check Box If the Aggregate Amount                                 [  ]
     in Row (9) Excludes Certain Shares
___________________________________________________________________________

11)  Percent of Class Represented                                    11.57%
     by Amount in Row (9)
___________________________________________________________________________

12)  Type of Reporting Person                                            CO
___________________________________________________________________________

















<PAGE>                                                                  3
CUSIP No.  04033A 10 0             13G
___________________________________________________________________________

1)   Name of Reporting Person and its         HMR Pharma, Inc.
     I.R.S. Identification Number             43-1769328
___________________________________________________________________________

2)   Check the Appropriate Box if                                  (a)[   ]
     a Member of a Group                                           (b)[   ]
___________________________________________________________________________

3)   SEC Use Only
___________________________________________________________________________

4)   Citizenship or Place of Organization                         Delaware
___________________________________________________________________________
     
               5)   Sole Voting Power                            2,526,316
Number of      ____________________________________________________________
Shares
Beneficially   6)   Shared Voting Power                                  0
Owned by       ____________________________________________________________
Each
Reporting      7)   Sole Dispositive Power                       2,526,316
Person With    ____________________________________________________________

               8)   Shared Dispositive Power                             0
___________________________________________________________________________

 9)  Aggregate Amount Beneficially Owned                         2,526,316
     by Each Reporting Person
___________________________________________________________________________

10)  Check Box If the Aggregate Amount                                 [  ]
     in Row (9) Excludes Certain Shares
___________________________________________________________________________

11)  Percent of Class Represented                                    11.57%
     by Amount in Row (9)
___________________________________________________________________________

12)  Type of Reporting Person                                            CO
___________________________________________________________________________

















<PAGE>                                                                4
CUSIP No.  04033A 10 0             13G

     This Statement on Schedule 13G (the "Schedule 13G") with respect to
the Common Stock of Ariad Pharmaceuticals, Inc. (the "Issuer"), is filed
jointly by Hoechst Marion Roussel, Inc., a Delaware corporation ("HMRI"),
and HMR Pharma, Inc., a Delaware corporation ("Pharma"), to replace the
Schedule 13D previously filed by the reporting persons, who have determined
pursuant to SEC Rule 13d-1(h) that the provisions of paragraphs (e), (f),
and (g) of Rule 13d-1 do not apply.

ITEM 1(a).   NAME OF ISSUER:  
- ----------   ---------------

             Ariad Pharmaceuticals Inc.           

ITEM 1(b).   ADDRESS OF ISSUER S PRINCIPAL EXECUTIVE OFFICES:
- ----------   ------------------------------------------------

             26 Landsdowne Street
             Cambridge, MA 02139

ITEM 2(a).   NAME OF PERSON FILING:  
- ----------   ----------------------

             Hoechst Marion Roussel, Inc.

             HMR Pharma, Inc.

ITEM 2(b).   ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
- ----------   ------------------------------------------------------------

             Hoechst Marion Roussel, Inc.
             10236 Marion Park Drive
             Kansas City, Missouri 64137-1405

             HMR Pharma, Inc.
             10236 Marion Park Drive
             Kansas City, Missouri 64137-1405 

ITEM 2(c).   CITIZENSHIP:  
- ----------   ------------  

             Delaware As To Both Hoechst Marion Roussel, Inc. And
             HMR Pharma, Inc.

ITEM 2(d).   TITLE OF CLASS OF SECURITIES:
- ----------   -----------------------------

             Common Stock, $.001 Par Value











<PAGE>                                                                  5
CUSIP No.  04033A 10 0             13G

ITEM 2(e):  CUSIP NUMBER:
- ----------  -------------

            04033A 10 0

ITEM 3:     IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(b) OR
            13D-2(b):    
- -------     -------------------------------------------------------
            Not Applicable

ITEM 4.     OWNERSHIP
- -------     ---------

    (a):    AMOUNT BENEFICIALLY OWNED:

            As Of 12/31/97 2,526,316 Shares Of Series B Convertible  
            Preferred Stock.  The Shares Are Convertible Into Common 
            Stock On A Share-For-Share Basis.

    (b):    PERCENT OF CLASS:  

            11.57%

    (c):    NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS:

     (i)    Sole power to vote or to direct the vote:       2,526,316
     
     (ii)   Shared power to vote or to direct the vote:             0
     
     (iii)  Sole power to dispose or to direct the          2,526,316       
            disposition of:
                                                       
     (iv)   Shared power to dispose or to direct the                0
            disposition of:
                                                         
ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
- -------   ---------------------------------------------
           Not Applicable

ITEM 6.    OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
- -------    ----------------------------------------------------------------
           Not Applicable
















<PAGE>                                                                 6
CUSIP No.  04033A 10 0             13G

ITEM 7.    IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH    
- -------    ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING  
           COMPANY
           ---------------------------------------------------------------
           Not Applicable

ITEM 8.    IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
- -------    ---------------------------------------------------------
           Not Applicable

ITEM 9.    NOTICE OF DISSOLUTION OF GROUP.
- -------    -------------------------------
           Not Applicable

ITEM 10.   CERTIFICATION.
- --------   --------------
           Not Applicable








































<PAGE>                                                                 7
CUSIP No.  04033A 10 0             13G


                                 SIGNATURE
                                 ----------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

                                    March 17, 1998
                                  ---------------------------------
                                    (Date)

                                   HMR PHARMA, INC.

                                   /s/ Rebecca R. Tilden
                                  --------------------------------- 
                                    (Signature)
                                   Rebecca R. Tilden
                                   Vice President and Secretary
                                  ---------------------------------
                                    (Name/Title)
                                   




































<PAGE>                                                                  8
CUSIP No.  04033A 10 0             13G

                                 SIGNATURE
                                 ----------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

                                    March 17, 1998
                                  ---------------------------------
                                    (Date)
                                   
                                   HOECHST MARION ROUSSEL, INC.

                                   /s/ Rebecca R. Tilden
                                  --------------------------------- 
                                    (Signature)
                                   Rebecca R. Tilden
                                   Vice President and Secretary
                                  ---------------------------------
                                    (Name/Title)
                                   




































<PAGE>                                                                 9
CUSIP No.  04033A 10 0             13G

                               EXHIBIT INDEX


Exhibit No.         Description                               Page No.
- -----------         ------------                              ---------

    99.A            Agreement to File Jointly dated March         10
                    17, 1998, by and between Hoechst Marion
                    Roussel, Inc. and HMR Pharma, Inc.
















<PAGE>                                                                10
CUSIP No.  04033A 10 0             13G

                              EXHIBIT 99.A
                              ------------


                      AGREEMENT TO FILE JOINTLY


     We, the undersigned, hereby express our agreement that the attached
Schedule 13G and all subsequent amendments thereto executed by both of us
are filed on behalf of each of us.


                                    HOECHST MARION ROUSSEL, INC.

      March 17, 1998                 /s/ Rebecca R. Tilden
- ---------------------------         -------------------------------------
          (Date)                       (Name and Title)
                                      Rebecca R. Tilden
                                      Vice President and Secretary
                                     
                                     HMR PHARMA, INC.

      March 17, 1998                  /s/ Rebecca R. Tilden
- ---------------------------         -------------------------------------
          (Date)                        (Name and Title)                   
                                     Rebecca R. Tilden
                                     Vice President and Secretary


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