MEDTRONIC INC
S-4, 1998-12-18
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
Previous: MAINE PUBLIC SERVICE CO, 8-K, 1998-12-18
Next: MERRILL LYNCH & CO INC, 8-A12B, 1998-12-18



<PAGE>
   AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 18, 1998
                                                    REGISTRATION NO: 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                           --------------------------
 
                                    FORM S-4
                             REGISTRATION STATEMENT
 
                                     UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------
 
                                MEDTRONIC, INC.
 
             (Exact name of registrant as specified in its charter)
 
<TABLE>
<S>                              <C>                            <C>
          MINNESOTA                          3845                  41-0793183
 (State or other jurisdiction    (Primary Standard Industrial   (I.R.S. Employer
              of                 Classification Code Number)     Identification
incorporation or organization)                                      Number)
</TABLE>
 
                            7000 CENTRAL AVENUE N.E.
                          MINNEAPOLIS, MINNESOTA 55432
 
                                 (612) 514-4000
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)
                           --------------------------
 
                               CAROL E. MALKINSON
                  SENIOR LEGAL COUNSEL AND ASSISTANT SECRETARY
                                MEDTRONIC, INC.
                            7000 CENTRAL AVENUE N.E.
                          MINNEAPOLIS, MINNESOTA 55432
                                 (612) 514-4000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
 
                                   COPIES TO:
 
DAVID C. GRORUD, ESQ.                     CRAIG E. DAUCHY, ESQ.
MARY E. STRAND, ESQ.                      RICHARD E. CLIMAN, ESQ.
Fredrikson & Byron, P.A.                  Cooley Godward LLP
900 Second Avenue South, Suite 1100       Five Palo Alto Square
Minneapolis, Minnesota 55402-3397         3000 El Camino Real
(612) 347-7000                            Palo Alto, California 94306-2155
                                          (650) 843-5000
 
                           --------------------------
 
   APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE OF THE SECURITIES TO THE
                                    PUBLIC:
 UPON CONSUMMATION OF THE MERGER, AS DESCRIBED IN THIS REGISTRATION STATEMENT.
 
    If the securities being registered on this Form are being offered in
connection with the formation of a holding company and there is compliance with
General Instruction G, check the following box. / /
 
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
 
    If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /
                        CALCULATION OF REGISTRATION FEE
 
<TABLE>
<CAPTION>
                                                                   PROPOSED MAXIMUM    PROPOSED MAXIMUM       AMOUNT OF
           TITLE OF EACH CLASS OF                 AMOUNT TO         OFFERING PRICE        AGGREGATE          REGISTRATION
        SECURITIES TO BE REGISTERED            BE REGISTERED(1)       PER SHARE         OFFERING PRICE          FEE(2)
<S>                                           <C>                 <C>                 <C>                 <C>
Common stock, par value $.10 per share(3)     58,146,865 shares     Not Applicable      Not Applicable       $901,697.34
</TABLE>
 
(1) Represents the approximate maximum number of shares issuable upon
    consummation of the Merger as described in the Registration Statement, based
    upon the anticipated maximum number of outstanding shares of Arterial
    Vascular Engineering, Inc. common stock at the Merger's Effective Time
    (65,900,000) and assuming the Average Stock Price for Medtronic, Inc. common
    stock is equal to or less than $61.20, resulting in the maximum Conversion
    Ratio of 0.88235 of a Medtronic, Inc. share issued for each Arterial
    Vascular Engineering, Inc. share.
 
(2) The registration fee was calculated pursuant to Section 6 of the Securities
    Act of 1933 (the "Securities Act") and Rules 457(f)(1) and 457(c)
    thereunder, as 0.000278 multiplied by the product of (A) 65,900,000, the
    anticipated maximum number of Arterial Vascular Engineering, Inc. shares
    that may be exchanged pursuant to the Merger, multiplied by (B) $49.21875,
    the average of the high and low sale prices of Arterial Vascular
    Engineering, Inc. common stock as reported by the Nasdaq National Market on
    December 15, 1998, which date was within five business days prior to the
    date of this filing.
 
(3) Each share of Medtronic common stock includes a Preferred Stock Purchase
    Right pursuant to Medtronic's Shareholder Rights Plan.
 
    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON
SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY
DETERMINE.
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
THE INFORMATION CONTAINED IN THIS PROXY STATEMENT/PROSPECTUS IS NOT COMPLETE AND
MAY BE CHANGED. WE MAY NOT DISTRIBUTE THESE SECURITIES UNTIL THE REGISTRATION
STATEMENT FILED WITH THE SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS
PROXY STATEMENT/PROSPECTUS IS NOT AN OFFER TO SELL THESE SECURITIES AND IS NOT
SOLICITING AN OFFER TO BUY THESE SECURITIES IN ANY STATE WHERE THE OFFER IS NOT
PERMITTED.
<PAGE>
         PRELIMINARY PROXY STATEMENT/PROSPECTUS, SUBJECT TO COMPLETION
 
                             [AVE LOGO/LETTERHEAD]
 
                  MERGER PROPOSED--YOUR VOTE IS VERY IMPORTANT
 
    The Board of Directors of Arterial Vascular Engineering, Inc. has
unanimously approved a merger between AVE and a subsidiary of Medtronic, Inc. As
a result of the proposed merger, AVE will become a wholly-owned subsidiary of
Medtronic and you will become a shareholder of Medtronic. The AVE Board believes
that the complementary product lines and businesses of Medtronic and AVE create
an overall strategic fit. It also believes that the merger should better allow
the combined company to benefit from developments in the health care industry
and to accelerate its product development and technological innovation.
 
    I cordially invite you to attend our special meeting of shareholders to vote
on a proposal to approve the merger and the merger agreement. We cannot complete
the merger unless the holders of a majority of the shares of AVE common stock
approve it.
 
    YOUR BOARD OF DIRECTORS HAS DETERMINED THAT THE MERGER IS FAIR TO YOU AND IN
YOUR BEST INTERESTS. THE BOARD UNANIMOUSLY RECOMMENDS THAT YOU VOTE TO APPROVE
THE MERGER AT THE SPECIAL MEETING.
 
    If the merger is completed, you will receive $54 in shares of Medtronic
common stock in exchange for each share of AVE common stock that you own, if the
average price of Medtronic common stock during a 15-trading-day period before
the shareholder meeting is between $61.20 and $74.80 per share. For each AVE
share, you will receive 0.88235 of a Medtronic share if the average price is
below $61.20 and 0.72193 of a Medtronic share if the average price is above
$74.80.
 
    Medtronic common stock is traded on the New York Stock Exchange under the
symbol "MDT." AVE common stock is traded on the Nasdaq National Market under the
symbol "AVEI."
 
    YOUR VOTE AT THE SPECIAL MEETING, IN PERSON OR BY PROXY, IS VERY IMPORTANT.
Even if you plan to attend the meeting, please mark, sign, and return the
enclosed proxy card promptly, so that your shares of common stock are voted at
the special meeting. If you do not return your proxy card, the effect will be a
vote against the merger unless you attend the meeting and vote for the merger.
To change your vote, send in a later-dated, signed proxy card to Lawrence
Fassler at AVE. If you do attend the meeting, you can of course vote your shares
in person.
 
    The date, time, and place of the meeting are:
 
[January 28], 1999
10:00 a.m., local time
Luther Burbank Center for the Arts
East Auditorium
50 Mark West Springs Road
Santa Rosa, California 95043
 
    This Proxy Statement/Prospectus gives you detailed information about the
merger. You can also obtain information about AVE and Medtronic from documents
filed with the Securities and Exchange Commission. Please read this entire
document carefully.
 
    WE ENTHUSIASTICALLY SUPPORT THE MERGER AND URGE YOU TO VOTE "FOR" THE MERGER
AND THE MERGER AGREEMENT.
 
    Thank you, and I look forward to seeing you at the special meeting.
 
Scott J. Solano
CHIEF EXECUTIVE OFFICER AND PRESIDENT
 
NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED THE MEDTRONIC SECURITIES TO BE ISSUED IN
THE MERGER OR DETERMINED IF THIS PROXY STATEMENT/ PROSPECTUS IS TRUTHFUL OR
COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
    Proxy Statement/Prospectus dated December 22, 1998, and first mailed to
shareholders on December 24, 1998.
<PAGE>
                      ARTERIAL VASCULAR ENGINEERING, INC.
                               3576 UNOCAL PLACE
                          SANTA ROSA, CALIFORNIA 95403
                   NOTICE OF SPECIAL MEETING OF SHAREHOLDERS
                         TO BE HELD [JANUARY 28], 1999
 
To the Shareholders of Arterial Vascular Engineering, Inc.:
 
    A Special Meeting of the shareholders of Arterial Vascular Engineering,
Inc., a Delaware corporation ("AVE"), will be held at Luther Burbank Center for
the Arts, East Auditorium, 50 Mark West Springs Road, Santa Rosa, California, on
Thursday, [January 28], 1999, at 10:00 a.m., local time, for the following
purposes:
 
    1.  To consider and vote upon a proposal to approve (i) an Agreement and
       Plan of Merger dated as of November 29, 1998 (the "Merger Agreement"),
       among Medtronic, Inc. ("Medtronic"), MAV Merger Corp. ("Merger
       Subsidiary"), and AVE, and (ii) the merger of Merger Subsidiary into AVE,
       pursuant to which AVE will become a wholly-owned subsidiary of Medtronic
       and holders of AVE common stock will receive shares of Medtronic common
       stock based upon the conversion ratio described in the accompanying Proxy
       Statement/Prospectus.
 
    2.  To transact such other business as may properly come before the Special
       Meeting or any adjournment or postponement, including a proposal to
       adjourn or postpone the Special Meeting.
 
    The record date for the Special Meeting is the close of business on December
21, 1998. Only AVE shareholders of record at that time are entitled to notice of
and to vote at the Special Meeting or any adjournment or postponement of it. To
approve the merger, the holders of a majority of the outstanding shares of AVE
common stock must vote in favor of the merger.
 
    Under Delaware law, AVE shareholders do not have a right to dissent from the
merger and obtain payment in cash for their shares.
 
    The attached Proxy Statement/Prospectus contains more detailed information
regarding the merger and the Merger Agreement and includes a copy of that
document.
 
    YOUR VOTE IS IMPORTANT. EVEN IF YOU EXPECT TO ATTEND THE SPECIAL MEETING,
PLEASE COMPLETE, SIGN, AND DATE THE ENCLOSED PROXY AND RETURN IT PROMPTLY IN THE
ENCLOSED POSTAGE-PAID ENVELOPE. IF NO INSTRUCTIONS ARE INDICATED ON YOUR PROXY,
YOUR SHARES WILL BE VOTED "FOR" THE MERGER. IF YOU DO NOT RETURN YOUR PROXY OR
VOTE IN PERSON, THE EFFECT IS A VOTE AGAINST THE MERGER. YOU CAN REVOKE YOUR
PROXY AT ANY TIME BEFORE IT IS EXERCISED BY GIVING WRITTEN NOTICE TO THE
SECRETARY OF AVE, OR FILING ANOTHER PROXY, OR ATTENDING THE SPECIAL MEETING AND
VOTING IN PERSON.
 
    IF THE MERGER AGREEMENT IS APPROVED AND THE MERGER IS CONSUMMATED, YOU WILL
BE SENT A LETTER OF TRANSMITTAL WITH INSTRUCTIONS FOR SURRENDERING YOUR
CERTIFICATES REPRESENTING SHARES OF AVE COMMON STOCK. PLEASE DO NOT SEND YOUR
SHARE CERTIFICATES UNTIL YOU RECEIVE THESE MATERIALS.
 
    THE AVE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT YOU VOTE FOR THE
MERGER.
 
                                          BY ORDER OF THE BOARD OF DIRECTORS
 
                                          Lawrence J. Fassler
                                          SECRETARY
 
December 22, 1998
<PAGE>
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                              <C>
QUESTIONS AND ANSWERS ABOUT THE MERGER.........     1
 
SUMMARY........................................     2
 
SPECIAL MEETING................................    11
Date, Place, and Time..........................    11
Purpose........................................    11
Record Date; Voting Rights; Quorum; Required
  Vote.........................................    11
Recommendation of Board of Directors of AVE....    12
Proxies; Revocation............................    12
Solicitation of Proxies........................    12
 
THE MERGER.....................................    12
General........................................    13
Effective Time of the Merger...................    13
Background of the Merger.......................    13
AVE's Reasons for the Merger; Recommendation of
  the AVE Board of Directors...................    15
Medtronic's Reasons for the Merger.............    17
Opinion of AVE's Financial Advisor.............    17
Conversion of AVE Common Stock in the Merger...    22
Shareholder Rights Plans.......................    24
Treatment of Stock Options.....................    24
Representations and Warranties.................    24
Certain Covenants by AVE.......................    25
Certain Covenants by Medtronic.................    26
Interests of AVE's Directors and Officers in
  the Merger...................................    26
Voting Agreements..............................    27
Stock Option Agreement.........................    28
Conditions to Consummation of the Merger;
  Waiver.......................................    28
Amendment and Termination of the Merger
  Agreement; Effects of Termination............    29
Expenses and Fees..............................    31
Restrictions on Resale of Medtronic Common
  Stock........................................    31
Deregistration of AVE Common Stock.............    32
Accounting Treatment of the Merger.............    32
Certain Federal Income Tax
  Consequences.................................    32
Indemnification................................    34
Regulatory Requirements........................    34
No Dissenters' Rights..........................    35
 
COMPARATIVE STOCK PRICES AND DIVIDENDS.........    35
 
RECENT DEVELOPMENTS............................    36
 
UNAUDITED PRO FORMA CONDENSED COMBINED
  FINANCIAL STATEMENTS.........................    37
 
COMPARISON OF RIGHTS OF MEDTRONIC AND AVE
  SHAREHOLDERS.................................    43
Classification, Removal, and Nomination of
  Directors....................................    43
Preferred Stock................................    44
Special Meetings of Shareholders...............    45
Voting Rights; Shareholder Approvals...........    45
Cumulative Voting..............................    45
Preemptive Rights..............................    45
Amendment of the Articles or Certificate of
  Incorporation................................    45
Business Combinations and Control Share
  Acquisitions.................................    46
Shareholder Rights Plans.......................    46
Related Person Business Transactions...........    47
 
CERTAIN TRANSACTIONS AND RELATIONSHIPS BETWEEN
  AVE AND MEDTRONIC............................    48
 
LEGAL MATTERS..................................    48
 
EXPERTS........................................    48
 
WHERE YOU CAN FIND MORE INFORMATION............    48
 
FORWARD-LOOKING
  INFORMATION..................................    51
 
LIST OF ANNEXES
  ANNEX A--Agreement and Plan of Merger
  ANNEX B--Opinion of SG Cowen Securities
    Corporation
</TABLE>
 
                                       i
<PAGE>
                     QUESTIONS AND ANSWERS ABOUT THE MERGER
 
    Q.  PLEASE DESCRIBE THE MERGER.
 
    A. In the merger, AVE will merge with a subsidiary of Medtronic and become a
wholly-owned subsidiary of Medtronic.
 
    Q.  WHAT WILL I RECEIVE IN THE MERGER?
 
    A. If the merger is completed, you will receive $54 in shares of Medtronic
common stock in exchange for each share of AVE common stock that you own, if the
average price of Medtronic stock during the 15 trading days ending on the second
trading day before the Special Meeting is between $61.20 and $74.80 per share.
 
    - If the average price is $61.20 or less, each AVE share will convert into
      0.88235 of a Medtronic share.
 
    - If the average price is between $61.20 and $74.80, each AVE share will
      convert into the portion of a Medtronic share equal to $54 divided by the
      average price.
 
    - If the average price is $74.80 or more, each AVE share will convert into
      0.72193 of a Medtronic share.
 
Because the conversion ratio will fluctuate based upon the market price of the
Medtronic common stock prior to the Special Meeting, depending on the actual
market price of Medtronic common stock on the date of the merger, you may
receive more or less than $54 in Medtronic common stock at the time of the
merger.
 
You will receive cash instead of any fractional Medtronic shares that you would
otherwise receive, based on the closing sale price of Medtronic stock on the
date of the merger.
 
    Q.  WHAT DO I NEED TO DO NOW?
 
    A. Please sign, date, and mail your proxy card in the enclosed return
envelope as soon as possible. You can also attend the Special Meeting in person
and vote, even though you already returned your proxy card. If you do not return
your proxy or vote in person, it will have the effect of a vote against the
merger.
 
    Q.  WHAT DO I DO IF I WANT TO CHANGE MY VOTE?
 
    A. Just send in a later-dated, signed proxy card before the Special Meeting
to Lawrence Fassler at AVE or attend the meeting in person and vote.
 
    Q.  IF MY SHARES ARE HELD IN "STREET NAME" BY MY BROKER, WILL MY BROKER VOTE
MY SHARES FOR ME?
 
    A. Your broker will vote your shares only if you provide instructions on how
to vote. You should instruct your broker to vote your shares, following the
procedure your broker gives you. Without instructions, your broker will not vote
your shares.
 
    Q.  SHOULD I SEND IN MY STOCK CERTIFICATES NOW?
 
    A. No. After we complete the merger, we will send you written instructions
that describe how to exchange your AVE stock certificates for Medtronic stock
certificates.
 
    Q.  WILL I OWE FEDERAL INCOME TAX ON WHAT I RECEIVE IN THE MERGER?
 
    A. We expect that your exchange of AVE stock for Medtronic stock in the
merger will be tax free for U.S. federal tax purposes, except to the extent you
receive cash for fractional Medtronic shares. The tax consequences of the merger
to you will depend on your own situation. You should talk to your tax advisor.
 
    Q.  WHEN DO YOU EXPECT TO COMPLETE THE MERGER?
 
    A. We are working toward completing the merger as quickly as possible.
Medtronic and AVE need to obtain both AVE shareholder approval and regulatory
approvals. Medtronic shareholders do not need to approve the merger. We hope to
complete the merger shortly after the Special Meeting, if regulatory approvals
and other required matters are completed by that time.
 
    Q.  WHOM SHOULD I CALL WITH QUESTIONS?
 
    A. If you have any questions about the merger, please call AVE Investor
Relations, at (707) 541-3135.
 
                                       1
<PAGE>
                                    SUMMARY
 
    THIS SUMMARY HIGHLIGHTS SELECTED INFORMATION FROM THIS PROXY
STATEMENT/PROSPECTUS AND MAY NOT CONTAIN ALL OF THE INFORMATION THAT IS
IMPORTANT TO YOU. TO UNDERSTAND THE MERGER FULLY AND FOR A MORE COMPLETE
DESCRIPTION OF THE LEGAL TERMS OF THE MERGER, YOU SHOULD READ CAREFULLY THIS
ENTIRE DOCUMENT AND THE DOCUMENTS TO WHICH WE HAVE REFERRED YOU. SEE "WHERE YOU
CAN FIND MORE INFORMATION" ON PAGE 48. WE HAVE INCLUDED PAGE REFERENCES IN
PARENTHESES TO DIRECT YOU TO A MORE COMPLETE DESCRIPTION OF SOME OF THE TOPICS
PRESENTED IN THIS SUMMARY.
 
THE COMPANIES
 
ARTERIAL VASCULAR ENGINEERING, INC.
3576 Unocal Place
Santa Rosa, California 95403
(707) 525-0111
 
AVE, a Delaware corporation founded in 1991, designs, develops, manufactures,
and markets a variety of highly specialized stent systems and percutaneous
transluminal coronary angioplasty ("PTCA") catheters and related devices
designed to be used in connection with less invasive treatment of cardiovascular
disease. AVE's stents are used as arterial support devices in connection with
balloon angioplasty or other minimally invasive treatments of atherosclerosis
(the formation of deposits in the arteries) and to prevent abrupt closure of
vessels in higher risk angioplasty procedures.
 
MEDTRONIC, INC.
7000 Central Avenue N.E.
Minneapolis, Minnesota 55432
(612) 514-4000
 
Medtronic, a Minnesota corporation founded in 1957, is the world's leading
medical technology company specializing in implantable and interventional
therapies. Its primary products include those for bradycardia pacing,
tachyarrhythmia management, atrial fibrillation management, heart failure
management, coronary and peripheral vascular disease, heart valve replacement,
extracorporeal cardiac support, minimally invasive cardiac surgery, malignant
and non-malignant pain, movement disorders, neurosurgery, and neurodegenerative
disorders. Medtronic serves customers and patients in more than 120 countries.
 
THE SPECIAL MEETING (PAGE 11)
 
The Special Meeting will be held on [January 28], 1999, at 10:00 a.m., local
time, at Luther Burbank Center for the Arts, East Auditorium, 50 Mark West
Springs Road, Santa Rosa, California. At the Special Meeting, you will be asked
to approve the merger and the merger agreement.
 
RECOMMENDATION TO AVE SHAREHOLDERS (PAGE 12)
 
The AVE Board of Directors believes that the merger is in the best interests of
AVE and its shareholders. The Board unanimously recommends that you vote "FOR"
approval of the merger and the merger agreement.
 
RECORD DATE (PAGE 11)
 
You can vote at the Special Meeting only if you owned shares of AVE common stock
at the close of business on December 21, 1998, which was the record date.
 
VOTE REQUIRED TO APPROVE THE MERGER (PAGE   )
 
The merger requires the approval of the holders of a majority of the outstanding
shares of AVE common stock. If you do not return your proxy or vote in person,
it will have the effect of a vote against the merger. Brokers who hold your
shares of AVE common stock as nominees cannot vote those shares unless you
instruct them to, following the procedure they give you.
 
Medtronic shareholders do not need to vote to approve the merger.
 
VOTING POWER; VOTING BY MANAGEMENT (PAGE 11)
 
On the record date, [64,462,351] shares of AVE common stock were outstanding. Of
these, [4,851,049] shares (approximately [7.5]% of the shares entitled to vote)
were beneficially owned by directors and executive officers of AVE (not
including options held by such persons). Each share of AVE common stock entitles
the holder to one vote.
 
                                       2
<PAGE>
All of AVE's directors and executive officers, who collectively beneficially own
[4,851,049] shares (or [7.5]%) of AVE's outstanding shares as of the record date
(not including options held by such persons), have executed voting agreements in
which they have agreed to vote the AVE common stock owned by them in favor of
the merger.
 
REVOKING PROXIES (PAGE 12)
 
You can revoke a proxy previously given by you by giving written notice to the
Secretary of AVE, Lawrence Fassler, by filing another proxy, or by attending the
Special Meeting and voting in person.
 
SUMMARY OF THE MERGER
 
THE MERGER AGREEMENT (ANNEX A) IS ATTACHED AT THE BACK OF THIS PROXY
STATEMENT/PROSPECTUS. WE ENCOURAGE YOU TO READ THE MERGER AGREEMENT, AS IT IS
THE LEGAL DOCUMENT THAT GOVERNS THE MERGER.
 
In the proposed merger, a subsidiary of Medtronic will merge into AVE, and AVE
will become a wholly-owned subsidiary of Medtronic. You will receive shares of
Medtronic common stock in exchange for your shares of AVE common stock.
 
EFFECTIVE TIME OF THE MERGER (PAGE 13)
 
Medtronic and AVE hope to complete the merger shortly after the Special Meeting,
if regulatory approvals and other required matters are completed by that time.
 
WHAT YOU WILL RECEIVE IN THE MERGER (PAGE 22)
 
If the merger is completed, you will receive $54 in Medtronic common stock for
each share of AVE common stock that you own, if the average closing price of
Medtronic stock is between $61.20 and $74.80 during the period described in the
next paragraph.
 
The exact number of Medtronic shares that you will receive in exchange for each
AVE share will equal $54 divided by the average closing price of Medtronic
common stock during the 15 trading days ending on the second trading day before
the Special Meeting. However, if the average price is $61.20 or less, each AVE
share will convert into 0.88235 of a Medtronic share, and if the average price
is $74.80 or more, each AVE share will convert into 0.72193 of a Medtronic
share.
 
The maximum conversion ratio of 0.88235 (if the average closing price of
Medtronic common stock is less than $61.20) means that, at the time of the
merger, you may receive less than $54 in Medtronic common stock for each AVE
share you own. Similarly, the minimum conversion ratio of 0.72193 (if the
average closing price is more than $74.80) means that you may receive more than
$54 in Medtronic common stock for each AVE share you own.
 
Each share of Medtronic common stock that you receive in the merger will also
represent one preferred stock purchase right under Medtronic's Shareholder
Rights Plan.
 
Medtronic will not issue any fractional shares. Instead, you will receive cash
for any fractional share of Medtronic common stock owed to you, based on the
closing sale price of Medtronic common stock on the date of the merger.
 
Please do not send in your stock certificates until you receive written
instructions to do so, after the merger.
 
WHAT HAPPENS TO STOCK OPTIONS (PAGE 24)
 
Following the merger, each outstanding option that you hold to buy AVE common
stock that was granted under one of AVE's stock option plans will become an
option to buy Medtronic common stock. Your options will continue to be governed
by the terms of the AVE stock option plans. However, the number of shares of
Medtronic common stock that you can purchase by exercising the options, and the
exercise price, will be adjusted to reflect the conversion ratio in the merger.
 
OWNERSHIP OF MEDTRONIC STOCK FOLLOWING THE MERGER (PAGE 22)
 
Following the merger, existing AVE shareholders will own approximately 9 percent
of the outstanding common stock of Medtronic (based upon the number of shares of
Medtronic common stock outstanding on December 21, 1998).
 
                                       3
<PAGE>
FEDERAL INCOME TAX CONSEQUENCES (PAGE 32)
 
We expect that neither AVE nor its shareholders will recognize gain or loss for
U.S. federal income tax purposes as a result of the merger, except for any taxes
payable by AVE shareholders on their receipt of cash instead of fractional
Medtronic shares. Each of AVE and Medtronic has received a legal opinion from
its counsel regarding these tax consequences.
 
TAX MATTERS ARE COMPLICATED, AND THE TAX CONSEQUENCES OF THE MERGER TO YOU WILL
DEPEND ON THE FACTS OF YOUR OWN SITUATION. WE URGE YOU TO CONTACT YOUR OWN TAX
ADVISOR TO UNDERSTAND FULLY HOW THE MERGER WILL AFFECT YOU, INCLUDING HOW ANY
STATE, LOCAL, OR FOREIGN TAX LAWS MAY APPLY TO YOU.
 
AVE'S REASONS FOR THE MERGER (PAGE 15)
 
The AVE Board believes that the merger offers you the opportunity to own stock
in a significantly larger and more actively traded business enterprise. The AVE
Board sees an overall strategic fit between AVE and Medtronic in view of their
complementary product lines and businesses. It also believes that the merger
should allow the combined company to better benefit from developments in the
health care industry and, as a result, to accelerate its product development and
technological innovation.
 
FAIRNESS OPINION OF AVE'S FINANCIAL ADVISOR (PAGE 17)
 
In deciding to approve the merger, the AVE Board considered the opinion of its
financial advisor, SG Cowen Securities Corporation, that, as of the date of such
opinion, and based upon the assumptions and limitations contained in it, the
Conversion Ratio (as defined below) was fair to AVE's shareholders from a
financial point of view. SG Cowen performed several analyses in connection with
its opinion. The opinion of SG Cowen is attached as Annex B to this Proxy
Statement/Prospectus. YOU SHOULD READ SG COWEN'S ENTIRE OPINION CAREFULLY.
 
INTERESTS OF AVE'S OFFICERS AND DIRECTORS IN THE MERGER (PAGE 26)
 
When considering the recommendation by the AVE Board to vote "FOR" the merger,
you should be aware that certain directors and executive officers of AVE have
interests in the merger that are different from, and may conflict with, your
interests. If we complete the merger, Medtronic will continue certain
indemnification arrangements for directors and officers of AVE. Certain
directors and officers of AVE will also receive certain benefits upon completion
of the merger, including accelerated vesting of stock options pursuant to
existing contractual arrangements. Some officers will also have the right to
receive severance benefits if Medtronic terminates their employment under
certain circumstances within a specified period after the merger. The AVE Board
was aware of these interests and considered them in approving the merger.
 
REGULATORY APPROVALS (PAGE 34)
 
Medtronic and AVE must both make filings with or obtain approvals from certain
United States and international antitrust authorities before they can complete
the merger. The merger cannot be completed until the companies receive approvals
or until a specified waiting period (typically 30 or more days) has passed after
the date of each filing. The waiting period may be extended by requests for
additional information. On December 8, 1998, Medtronic and AVE each filed the
required notification and report forms with the United States antitrust
agencies.
 
We cannot predict whether we will obtain all required regulatory approvals for
the merger, or whether any approvals will include conditions that may be
detrimental to Medtronic or AVE.
 
CONDITIONS TO THE MERGER (PAGE 28)
 
The merger will be completed only if certain conditions, including the
following, are met or waived:
 
    - the AVE shareholders approve the merger;
 
    - the waiting periods under the HSR Act or foreign merger laws expire or
      terminate;
 
                                       4
<PAGE>
    - no court orders prevent the merger or impose material limitations on the
      ownership or operation of AVE after the merger;
 
    - AVE and Medtronic both receive letters from their accountants stating that
      the merger qualifies for pooling of interests accounting treatment;
 
    - AVE receives an opinion from its tax counsel that the merger will qualify
      as a tax-free transaction; and
 
    - the representations and warranties made by Medtronic and AVE continue to
      be accurate except for inaccuracies that would not have a material adverse
      effect.
 
TERMINATION OF THE MERGER AGREEMENT (PAGE 29)
 
Even if the AVE shareholders approve the merger, Medtronic and AVE can agree at
any time to terminate the merger agreement without completing the merger. The
merger agreement can also be terminated if any of the following occurs:
 
    - the merger is not completed by May 31, 1999 (or, if there is additional
      regulatory review, October 31, 1999);
 
    - a court or other governmental authority prohibits the merger; or
 
    - the AVE shareholders do not approve the merger.
 
Medtronic can terminate the merger agreement if the AVE Board approves or
permits a different acquisition proposal, or otherwise changes its
recommendation of the merger.
 
AVE can also terminate the merger agreement if it authorizes acceptance of a
more favorable acquisition proposal, Medtronic does not match the proposal, and
AVE pays a termination fee to Medtronic.
 
TERMINATION FEES AND EXPENSES (PAGE 29)
 
AVE must pay Medtronic a termination fee of $135 million in cash if the merger
agreement is terminated in any of the following circumstances:
 
    - the AVE Board withdraws its recommendation of the merger, recommends or
      approves a different acquisition proposal, or does not recommend against a
      competing tender offer or exchange offer;
 
    - AVE accepts a more favorable acquisition proposal and Medtronic does not
      match the proposal; or
 
    - the AVE shareholders do not approve the merger (but only if a different
      acquisition proposal has been announced, AVE enters into an agreement with
      a third party relating to a different acquisition proposal within 12
      months after the termination, and AVE consummates an acquisition
      transaction with the same third party or its affiliates within 24 months
      after entering into such agreement).
 
STOCK OPTION AGREEMENT (PAGE 28)
 
Medtronic and AVE have also entered into a stock option agreement, which gives
Medtronic an option to purchase from AVE up to 19.9% of AVE's common stock for
an exercise price of $54 per share. The option becomes exercisable only if
certain events related to termination of the merger agreement occur. Medtronic
can also, upon certain events related to termination of the merger agreement,
cancel the option in exchange for a cancellation payment by AVE. The sum of any
termination fee and the amount of any option cancellation payment can never
exceed $150 million.
 
AVE CANNOT SOLICIT OTHER OFFERS (PAGE 25)
 
AVE has agreed not to encourage, solicit, discuss, or negotiate with anyone
(other than Medtronic) regarding a merger, sale, or license of a specified
portion of AVE's assets or stock, unless AVE receives an unsolicited superior
acquisition proposal and AVE's Board must do
 
                                       5
<PAGE>
so to meet its fiduciary obligations to the AVE shareholders.
 
NO DISSENTERS' RIGHTS
 
Under Delaware law, AVE shareholders do not have any right to an appraisal of
the value of their shares in connection with the merger, or to be paid that
value in cash.
 
ACCOUNTING TREATMENT (PAGE 32)
 
Medtronic and AVE expect the merger to qualify as a "pooling of interests,"
which means that they will treat the two companies as if they had always been
combined for accounting and financial reporting purposes.
 
COMPARATIVE PRICES OF MEDTRONIC AND AVE COMMON STOCK (PAGE 35)
 
Medtronic common stock is listed on the New York Stock Exchange and AVE common
stock is traded on the Nasdaq National Market. On November 27, 1998, the last
trading day before the public announcement of the proposed merger, Medtronic
common stock closed at $70.00 and AVE common stock closed at $32.375. On
[December 15], 1998, Medtronic common stock closed at $[68.125] and AVE common
stock closed at $[49.00].
 
Following the merger, AVE common stock will no longer trade on the Nasdaq
National Market or any other exchange.
 
FLUCTUATIONS IN MARKET PRICE (PAGE 22)
 
The number of shares of Medtronic common stock that AVE shareholders will
receive in the merger will depend on the market value of Medtronic common stock
during a specific period prior to the Special Meeting. The market value of
Medtronic common stock is likely to change, both before and after the Special
Meeting and the merger. No one can accurately predict what the market value will
be at any particular time.
 
LISTING OF MEDTRONIC COMMON STOCK
 
Medtronic will list the shares of its common stock to be issued in the merger on
the New York Stock Exchange.
 
DIFFERENCES IN RIGHTS OF MEDTRONIC'S AND AVE'S SHAREHOLDERS (PAGE 43)
 
The rights of AVE shareholders are governed by Delaware law and the Certificate
of Incorporation and Bylaws of AVE. When the merger is completed, AVE
shareholders will become shareholders of Medtronic, and their rights will be
governed by Minnesota law and the Articles of Incorporation and Bylaws of
Medtronic. The rights of AVE shareholders and Medtronic shareholders differ in
certain respects.
 
Another significant difference between Medtronic common stock and AVE common
stock is that Medtronic has historically paid regular quarterly cash dividends
on Medtronic common stock, and AVE has never paid any cash dividends.
 
FORWARD-LOOKING STATEMENTS (PAGE 51)
 
This document (and documents to which we refer you in this document) includes
various forward-looking statements about Medtronic, AVE, and the combined
company that are subject to risks and uncertainties. Forward-looking statements
include information concerning future results of operations of Medtronic, AVE,
and the combined company. Also, statements that use the words "anticipates,"
"believes," "estimates," "expects," "intends," "plans," "should," "will," or
similar expressions are forward-looking statements. Many factors, some of which
are discussed elsewhere in this document and in documents to which we have
referred you, could affect the future financial results of Medtronic, AVE, and
the combined company. These factors could cause actual results to differ
materially from those expressed in forward-looking statements contained in this
document or related documents. These factors include adverse changes in economic
conditions and in the markets served by Medtronic and AVE and a significant
delay in the completion of the merger.
 
                                       6
<PAGE>
                       SELECTED HISTORICAL FINANCIAL DATA
 
    The following tables show summarized historical financial data for each of
Medtronic and AVE. Medtronic's historical financial data has been restated for
its merger with Physio-Control International Corporation ("Physio-Control"),
which occurred on September 30, 1998. The information in the following tables is
based on historical financial information that the companies have included in
their prior SEC filings. You should read all of the summary financial
information shown in the following tables in connection with this historical
financial information. This historical financial information has also been
incorporated into this document by reference. See "Where You Can Find More
Information" on page 48. Medtronic's audited historical financial statements
were audited by PricewaterhouseCoopers LLP, independent accountants, and AVE's
audited historical financial statements were audited by Ernst & Young LLP,
independent accountants.
 
                                MEDTRONIC, INC.
               SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA(1)
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
 
<TABLE>
<CAPTION>
                                                                                                SIX MONTHS ENDED
                                                       YEAR ENDED APRIL 30,                   --------------------
                                       -----------------------------------------------------   OCT 31,    OCT 30,
                                         1994       1995       1996       1997      1998(3)     1997      1998(4)
                                       ---------  ---------  ---------  ---------  ---------  ---------  ---------
                                                                                                  (UNAUDITED)
<S>                                    <C>        <C>        <C>        <C>        <C>        <C>        <C>
Net sales............................  $1,498,051 $1,892,420 $2,326,836 $2,609,361 $2,783,371 $1,377,508 $1,434,060
Net earnings.........................    196,410    297,233    436,138    544,584    466,877    294,359    299,435
Basic earnings per share(2)..........       0.42       0.64       0.90       1.12       0.98       0.62       0.62
Earnings per share assuming
  dilution(2)........................       0.42       0.62       0.89       1.10       0.96       0.61       0.61
Total assets.........................  1,706,297  2,040,276  2,638,537  2,509,308  2,887,387  2,714,411  3,834,575
Long-term debt.......................     20,232     50,696     40,046     36,116     32,758     36,647     19,534
Cash dividends per share(2)..........       0.08       0.10       0.13       0.19       0.22       0.11       0.13
</TABLE>
 
                      ARTERIAL VASCULAR ENGINEERING, INC.
                SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
 
<TABLE>
<CAPTION>
                                                                                                   THREE MONTHS ENDED
                                                            YEAR ENDED JUNE 30,                   --------------------
                                           -----------------------------------------------------  SEPT 30,   SEPT 30,
                                             1994       1995       1996       1997       1998       1997       1998
                                           ---------  ---------  ---------  ---------  ---------  ---------  ---------
                                                                                                      (UNAUDITED)
<S>                                        <C>        <C>        <C>        <C>        <C>        <C>        <C>
Net sales................................  $   2,897  $  17,141  $  55,228  $  79,420  $ 387,645  $  26,263  $ 161,268
Net earnings.............................       (538)     6,640     20,440     21,750    115,120      5,710     53,177
Basic earnings per share.................      (0.02)      0.18       0.44       0.37       1.86       0.10       0.84
Earnings per share assuming dilution.....      (0.02)      0.13       0.36       0.34       1.76       0.09       0.80
Total assets.............................      3,086     13,089    122,157    147,979    387,469    165,934    437,927
Long-term debt...........................          0          0          0          0          0          0          0
Cash dividends per share.................          0          0          0          0          0          0          0
</TABLE>
 
- ------------------------------
 
(1) Prior to the merger of Medtronic and Physio-Control, Physio-Control reported
    its financial results on the basis of a fiscal year ending December 31,
    while Medtronic reports its financial results on the basis of a fiscal year
    ending April 30. The combined balance sheets of Medtronic at April 30
    present the historical financial position of Medtronic at April 30 combined
    with the historical financial position of Physio-Control at March 31. The
    combined results of operations for the fiscal years ended April 30 represent
    the historical results of operations of Medtronic for the fiscal years ended
    April 30 combined with the historical results of operations of
    Physio-Control for the 12 months ended March 31. The combined balance sheet
    of Medtronic at October 31, 1997 presents the historical financial position
    of Medtronic at that date combined with the historical financial position of
    Physio-Control at September 30, 1997. The combined results of operations for
    the six months ended October 31, 1997 represent the historical results of
    operations of Medtronic for the six months ended on that date combined with
    the historical results of operations of Physio-Control for the six months
    ended September 30, 1997.
 
                                       7
<PAGE>
(2) In each of September 1994, September 1995, and September 1997, Medtronic
    effected a two-for-one common stock split, paid in the form of a 100% stock
    dividend. All references to earnings per share and cash dividends per share
    have been restated to reflect these stock splits.
 
(3) Net earnings, basic earnings per share, and earnings per share assuming
    dilution reflect the impact of $205.3 million pre-tax nonrecurring charges
    recorded in the third quarter of fiscal 1998.
 
(4) Net earnings, basic earnings per share, and earnings per share assuming
    dilution reflect the impact of $21.1 million pre-tax transaction-related
    charges from the merger with Physio-Control.
 
                                       8
<PAGE>
                           COMPARATIVE PER SHARE DATA
 
    The following tables show, for Medtronic and AVE, summarized historical
information and summarized pro forma information reflecting the merger. The pro
forma information reflects the "pooling of interests" method of accounting. The
pro forma information, while helpful in showing the financial characteristics of
the combined company under one set of assumptions, does not attempt to predict
or suggest future operating results or financial position. It also does not
necessarily reflect what the historical results of the combined company would
have been if the two companies had been combined earlier. See "Where You Can
Find More Information" on page 48. For further pro forma financial information
regarding this and other pending transactions, see "Unaudited Pro Forma
Condensed Combined Financial Statements" on page 37.
 
<TABLE>
<CAPTION>
                                                                                      BASIC         DILUTED
                                                                                    EARNINGS       EARNINGS
                                                                                      FROM           FROM
                                                                         BOOK      CONTINUING     CONTINUING       CASH
                                                                         VALUE     OPERATIONS     OPERATIONS     DIVIDENDS
                                                                       ---------  -------------  -------------  -----------
<S>                                                                    <C>        <C>            <C>            <C>
MEDTRONIC HISTORICAL PER SHARE DATA(1):
At and for the 6 months ended October 30, 1998(2)....................  $    5.95    $    0.62      $    0.61     $    0.13
At and for the fiscal year ended April 30, 1998(3)...................       4.41         0.98           0.96          0.22
For the fiscal year ended April 30, 1997.............................      *             1.12           1.10          0.19
For the fiscal year ended April 30, 1996.............................      *             0.90           0.89          0.13
 
AVE HISTORICAL PER SHARE DATA:
At and for the 3 months ended September 30, 1998.....................       5.26         0.84           0.80             0
For the fiscal year ended June 30, 1998..............................       4.33         1.86           1.76             0
At and for the 12 months ended March 31, 1998........................       3.38         0.99           0.93             0
For the fiscal year ended June 30, 1997..............................      *             0.37           0.34             0
For the 12 months ended March 31, 1997...............................      *             0.43           0.39             0
For the fiscal year ended June 30, 1996..............................      *             0.44           0.36             0
For the 12 months ended March 31, 1996...............................      *             0.36           0.28             0
 
MEDTRONIC(1) AND AVE PRO FORMA COMBINED DATA:
MEDTRONIC PER SHARE PRO FORMA COMBINED DATA(1):
At and for the 6 months ended October 30, 1998(2)(4).................       6.01         0.78           0.76          0.12
At and for the fiscal year ended April 30, 1998(3)(5)................       4.40         1.00           0.98          0.20
For the fiscal year ended April 30, 1997(6)..........................      *             1.07           1.05          0.17
For the fiscal year ended April 30, 1996(7)..........................      *             0.87           0.84          0.12
 
AVE PER SHARE EQUIVALENT(8) PRO FORMA COMBINED DATA:
At and for the 6 months ended October 30, 1998(2)(4).................       4.77         0.62           0.60          0.09
At and for the fiscal year ended April 30, 1998(3)(5)................       3.49         0.80           0.78          0.16
For the fiscal year ended April 30, 1997(6)..........................      *             0.85           0.83          0.14
For the fiscal year ended April 30, 1996(7)..........................      *             0.69           0.67          0.09
</TABLE>
 
- ------------------------------
 
(1) Medtronic's historical financial data has been restated for its merger with
    Physio-Control, which occurred on September 30, 1998. Prior to that merger,
    Physio-Control reported its financial results on the basis of a fiscal year
    ending December 31, while Medtronic reports its financial results on the
    basis of a fiscal year ending April 30. The combined balance sheets of
    Medtronic at April 30 present the historical financial position of Medtronic
    at April 30 combined with the historical financial position of
    Physio-Control at March 31. The combined results of operations for the
    fiscal years ended April 30 represent the historical results of operations
    of Medtronic for the fiscal years ended April 30 combined with the
    historical results of operations of Physio-Control for the 12 months ended
    March 31.
 
(2) Basic earnings from continuing operations and diluted earnings from
    continuing operations reflect the impact of $21.1 million pre-tax
    transaction-related charges from the merger with Physio-Control.
 
                                       9
<PAGE>
(3) Basic earnings from continuing operations and diluted earnings from
    continuing operations reflect the impact of $205.3 million pre-tax
    nonrecurring charges recorded in the third quarter of fiscal 1998.
 
(4) The combined pro forma data combine the financial information of Medtronic
    at and for the six months ended October 30, 1998 with the financial
    information of AVE at and for the six months ended September 30, 1998.
 
(5) The combined pro forma data combine the financial information of Medtronic
    at and for the year ended April 30, 1998 with the financial information of
    AVE at and for the 12-month period ended March 31, 1998.
 
(6) The combined pro forma data combine the financial information of Medtronic
    for the year ended April 30, 1997 with the financial information of AVE for
    the 12-month period ended March 31, 1997.
 
(7) The combined pro forma data combine the financial information of Medtronic
    for the year ended April 30, 1996 with the financial information of AVE for
    the 12-month period ended March 31, 1996.
 
(8) The AVE per share equivalent pro forma combined information represents the
    Medtronic per share pro forma combined net income and book value multiplied
    by [0.79266], which is the assumed Conversion Ratio (based on an assumed
    Medtronic average stock price of [$68.125], which was the closing price of
    Medtronic common stock on December 17, 1998) solely for purposes of this
    illustration.
 
 *  Disclosure is not required.
 
                                       10
<PAGE>
                                SPECIAL MEETING
 
    Medtronic and AVE are sending this Proxy Statement/Prospectus to the
shareholders of AVE in connection with the solicitation by the Board of
Directors of AVE of proxies to be voted at the Special Meeting. This Proxy
Statement/Prospectus is first being mailed to shareholders of AVE on or about
December 24, 1998.
 
DATE, PLACE, AND TIME
 
    The Special Meeting will be held at 10:00 a.m. on [January 28], 1999, local
time, at Luther Burbank Center for the Arts, East Auditorium, 50 Mark West
Springs Road, Santa Rosa, California.
 
PURPOSE
 
    At the Special Meeting, AVE shareholders will be asked to vote on a proposal
to approve the Agreement and Plan of Merger dated as of November 29, 1998 (the
"Merger Agreement") attached to this Proxy Statement/Prospectus as Annex A. That
document provides for the merger (the "Merger") of MAV Merger Corp., a
wholly-owned subsidiary of Medtronic ("Merger Subsidiary"), with and into AVE,
as a result of which AVE will become a wholly-owned subsidiary of Medtronic.
Other terms and provisions related to the Merger are contained in the Merger
Agreement.
 
    AVE shareholders may also be asked to vote upon a proposal to adjourn or
postpone the Special Meeting, in order to (among other things) allow additional
time for the companies to solicit additional votes to approve the Merger. If any
matters other than approval of the Merger are properly presented for
consideration at the Special Meeting, the persons named by shareholders in the
enclosed form of proxy will have discretion, as proxies, to vote on those
matters.
 
    Under Delaware law, shareholders can consider at the Special Meeting only
the matters contained in the notice for the Special Meeting.
 
RECORD DATE; VOTING RIGHTS; QUORUM; REQUIRED VOTE
 
    The close of business on December 21, 1998 is the record date for
determining the holders of AVE common stock who are entitled to receive notice
of and to vote at the Special Meeting or at any adjournment of the Special
Meeting.
 
    AVE has only one class of capital stock outstanding, which is common stock,
par value $.001 per share. Each holder of AVE common stock outstanding on the
record date is entitled to one vote for each share held. The holders of a
majority of the outstanding shares of AVE common stock entitled to vote must be
present at the Special Meeting, in person or by proxy, to constitute a quorum to
transact business.
 
    The holders of a majority of the outstanding shares of AVE common stock as
of the record date must vote in favor of the Merger in order to approve the
Merger. On the record date, [64,462,351] shares of AVE common stock were
outstanding, held by approximately [345] holders of record. Of such shares,
[4,851,049] shares (approximately [7.5]% of the outstanding shares of AVE common
stock) were beneficially owned by directors and executive officers of AVE (not
including options held by such persons) who have executed voting agreements
under which they agreed to vote shares of AVE common stock beneficially owned by
them in favor of the Merger.
 
    Abstentions will be treated as shares present in determining whether AVE has
a quorum for the Special Meeting, but abstentions will have the same effect as a
vote against approval of the Merger. If a broker or other record holder or
nominee indicates on a proxy that it does not have direction or authority to
vote certain shares, those shares will be considered present at the Special
Meeting for purposes of determining a quorum but will have the same effect as a
vote against approval of the Merger. See "The Merger--Voting Agreements."
 
                                       11
<PAGE>
    The Board of Directors of AVE has unanimously approved the Merger. The Board
of Directors of Medtronic has approved the Merger and the issuance of shares of
Medtronic common stock in the Merger. See "The Merger--Background of the
Merger." Minnesota law does not require that Medtronic shareholders approve the
Merger. Medtronic, as the sole shareholder of Merger Subsidiary, has approved
the Merger.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS OF AVE
 
    THE BOARD OF DIRECTORS OF AVE RECOMMENDS THAT THE SHAREHOLDERS VOTE FOR THE
APPROVAL OF THE MERGER AGREEMENT. See "The Merger--Interests of AVE's Directors
and Officers in the Merger" for a discussion of conflicts of interest that
certain directors and members of management may have in connection with the
Merger.
 
PROXIES; REVOCATION
 
    A proxy card is enclosed for use by AVE shareholders. The Board of Directors
of AVE requests that shareholders SIGN AND RETURN THE PROXY CARD IN THE
ACCOMPANYING ENVELOPE. No postage is required if mailed within the United
States. IF YOU HAVE QUESTIONS OR REQUESTS FOR ASSISTANCE IN COMPLETING AND
SUBMITTING PROXY CARDS, PLEASE CONTACT CORPORATE INVESTOR COMMUNICATIONS, A FIRM
THAT PROVIDES PROFESSIONAL PROXY SOLICITING SERVICES THAT AVE HAS RETAINED, AT
THE FOLLOWING ADDRESS AND TELEPHONE NUMBER:
 
                           Corporate Investor Communications
                           111 Commerce Road
                           Carlstadt, NJ 07072
                           Telephone: (615) 896-5600
 
    All properly executed proxies that are not revoked will be voted at the
Special Meeting as instructed on those proxies. Proxies containing no
instructions will be voted in favor of the Merger. A shareholder who executes
and returns a proxy may revoke it at any time before it is voted, but only by
executing and returning a proxy bearing a later date, by giving written notice
of revocation to an officer of AVE, or by attending the Special Meeting and
voting in person.
 
    SHAREHOLDERS SHOULD NOT SEND THEIR STOCK CERTIFICATES WITH THEIR PROXY
CARDS.
 
SOLICITATION OF PROXIES
 
    In addition to soliciting proxies by mail, AVE's directors, officers, and
employees may, if they do not receive extra compensation for doing so, solicit
proxies personally or by telephone or fax. In addition, AVE has retained
Corporate Investor Communications to assist in soliciting proxies from brokers,
bank nominees, institutional holders, and other AVE shareholders and to serve as
information agent in connection with the Merger. Corporate Investor
Communications will receive from AVE reasonable and customary compensation for
its services and reimbursement of reasonable out-of-pocket expenses. AVE intends
to reimburse brokerage houses and other custodians, nominees, and fiduciaries
for reasonable out-of-pocket expenses incurred in forwarding copies of
solicitation material to beneficial owners of AVE common stock held of record by
those persons. AVE and Medtronic have agreed to share equally all expenses
relating to the printing and mailing of this Proxy Statement/Prospectus and the
filing of it with the Securities and Exchange Commission (the "SEC").
 
                                   THE MERGER
 
    THE FOLLOWING SUMMARY OF THE MERGER AND CERTAIN TERMS OF THE MERGER
AGREEMENT AND RELATED MATTERS IS NOT COMPLETE AND IS QUALIFIED IN ITS ENTIRETY
BY REFERENCE TO THE MERGER AGREEMENT, WHICH IS ATTACHED AS ANNEX A AND IS
INCORPORATED IN THIS DOCUMENT BY REFERENCE.
 
                                       12
<PAGE>
GENERAL
 
    Medtronic, Merger Subsidiary, and AVE have entered into the Merger
Agreement, which provides that Merger Subsidiary will be merged with and into
AVE, and AVE will become a wholly-owned subsidiary of Medtronic. In the Merger,
AVE will change its name to "Medtronic Arterial Vascular Engineering, Inc." Each
outstanding share of AVE common stock will be converted at the Effective Time
(as defined below) into the right to receive $54 in shares of Medtronic common
stock, if the Average Stock Price (as defined below) of Medtronic common stock
is between $61.20 and $74.80 for a specified period, as described in further
detail below. See "The Merger--Conversion of AVE Common Stock in the Merger."
 
EFFECTIVE TIME OF THE MERGER
 
    As soon as practicable after the conditions to consummation of the Merger
described below have been satisfied or waived, and unless the Merger Agreement
has been terminated as provided below, a certificate of merger will be filed
with the Secretary of State of the State of Delaware, at which time the Merger
will become effective (the "Effective Time"). It is presently contemplated that
the Effective Time will be as soon as practicable after approval of the Merger
at the Special Meeting and after the waiting periods under the HSR Act and any
applicable foreign merger laws expire or terminate. See "The Merger--Conditions
to the Merger; Waiver."
 
BACKGROUND OF THE MERGER
 
    The terms of the Merger Agreement are the result of arm's-length
negotiations between representatives of Medtronic and AVE. The following is a
brief discussion of the background of these negotiations, the Merger, and
related transactions.
 
    On November 5, 1998, Mr. Solano received a telephone call from Glen Nelson,
M.D., Vice Chairman of Medtronic, who indicated an interest in meeting to
discuss a potential business combination transaction. Mr. Solano agreed to
explore the issue. On November 10, 1998, Mr. Solano met with William George,
Medtronic's Chairman and Chief Executive Officer, Dr. Nelson, and Michael
Ellwein, Medtronic's Vice President and Chief Development Officer, at a health
care conference in Dallas, Texas. They first discussed the general state of the
vascular marketplace and consolidation in the medical device industry and then
the possible structure and financial terms of a business combination, particular
patent matters affecting both AVE and Medtronic, and other issues involved with
a business combination transaction. Both parties agreed to have more detailed
discussions about the matter.
 
    On November 12, 1998, the AVE Board of Directors held a regularly scheduled
meeting at which Mr. Solano informed the members of the AVE Board of the outcome
of his meeting with Medtronic. The AVE Board discussed a framework for
discussions regarding a possible combination of AVE and Medtronic, including
that any transaction be tax-free to AVE shareholders, that any definitive
acquisition agreement have a limited number of closing conditions, and that any
negotiations be conducted rapidly and efficiently to assure minimal impact on
the continued operations of AVE or other potential business opportunities if an
agreement were not reached. The AVE Board authorized Mr. Solano to continue
discussions with Medtronic regarding the potential business combination.
 
    On November 13, 1998, AVE and Medtronic executed a confidentiality agreement
and began to exchange non-public information. In addition, representatives of SG
Cowen Securities Corporation ("SG Cowen"), AVE's financial advisor, discussed
the proposed transaction with management members of the AVE Board.
 
    On November 17, 1998, Medtronic's legal counsel delivered to AVE an initial
draft of the Merger Agreement, the Stock Option Agreement, and related
transaction agreements.
 
                                       13
<PAGE>
    On November 18 and 19, 1998, members of Medtronic's senior management and
representatives of its legal and financial advisors met in Santa Rosa,
California, to hear presentations by members of AVE's senior management about
AVE's product opportunities, market positioning, patent matters, and other
business matters and to ask questions about such matters. In addition, Medtronic
representatives began a due diligence investigation of AVE's financial
information, legal relationships, and other due diligence materials. Mr. Solano
and Mr. George also further discussed their views regarding the strategic fit
between the two companies and the importance of the role of key members of AVE's
management in the combined company in order to optimize the expected benefits of
the proposed merger.
 
    On November 20, 1998, internal and outside counsel for both companies spoke
by telephone to discuss various issues regarding the draft Merger Agreement.
Related telephone conversations among the parties and their advisors continued
regularly until final drafts of the Merger Agreement and the related transaction
documents were prepared for execution.
 
    On November 20, 1998, the AVE Board held an informal meeting, which included
representatives of AVE's legal and financial advisors. Representatives of AVE's
financial advisor held further discussions with the AVE Board regarding the
potential business combination. Mr. Solano led a detailed discussion of the
status of the proposed transaction, the strategic fit between the two companies,
the merits and risks of the proposed transaction, and the potential financial
terms of the proposed transaction.
 
    On November 23, 1998, Mr. Solano and Mr. Miller met with Dr. Nelson to
discuss the financial terms of the proposed business combination and certain
other issues relating to the transaction. That evening, Mr. Solano and Mr.
Miller informally advised the other members of the AVE Board, as well as
representatives of AVE's financial advisor, regarding the status of the
negotiations.
 
    On November 24, 1998, members of AVE's senior management and representatives
of its legal and financial advisors met at Medtronic's facility to hear
presentations by members of Medtronic's senior management about Medtronic's
product opportunities, recent and pending acquisitions, ongoing litigation, and
other business matters and to ask questions about such matters. In addition,
throughout that day, Mr. Solano, Mr. Miller, and representatives of AVE's
financial advisor continued discussions with Dr. Nelson, Mr. Ellwein, and
representatives of Medtronic's financial advisor regarding the financial terms
of the proposed business combination.
 
    On November 24, 1998, the Board of Directors of Medtronic approved the
acquisition of AVE, subject to final negotiations by senior management, and
authorized Medtronic's officers to undertake all acts necessary or desirable to
effect the Merger.
 
    Early in the evening of November 24, 1998, Mr. Solano stated that he would
discuss with the AVE Board the financial terms ultimately reflected in the
Merger Agreement.
 
    From November 24 through 29, 1998, AVE, Medtronic, and their respective
legal counsel negotiated the terms of the Merger Agreement and related
transaction documents.
 
    On November 29, 1998, the AVE Board held a special meeting. Representatives
of SG Cowen discussed the financial analysis of the Conversion Ratio and
delivered its opinion to the AVE Board that, as of such date, the Conversion
Ratio was fair, from a financial point of view, to AVE's shareholders. See Annex
B for a copy of such opinion, which sets forth the assumptions made and matters
considered in, and the limitations on, the review undertaken by SG Cowen. See
also "--Opinion of AVE's Financial Advisor" for a discussion of the
methodologies used by SG Cowen in its analysis. AVE's legal advisors then
reviewed with the AVE Board the terms of the final drafts of the Merger
Agreement, the Stock Option Agreement, and the related transaction documents.
The AVE Board discussed and considered the materials presented at the meeting,
including final drafts of the agreements and SG Cowen's analysis of the
Conversion Ratio. Members of Medtronic management were also at AVE's Santa Rosa
facilities during the AVE Board meeting, and they negotiated with members of AVE
management certain outstanding issues during requested interruptions of the AVE
Board meeting. Following duscussion of the issues and materials
 
                                       14
<PAGE>
presented, the AVE Board unanimously determined that the Merger was fair to, and
in the best interests of, AVE and its shareholders. The AVE Board also approved
the Merger Agreement, the Stock Option Agreement, and related transaction
documents and recommended that AVE's shareholders approve the Merger Agreement
and the Merger.
 
    On November 29, 1998, following the conclusion of the meeting of the AVE
Board, representatives of Medtronic and AVE executed the Merger Agreement and
Stock Option Agreement. At the same time, the appropriate parties executed
certain related voting agreements and affiliates' letters of executive officers
and directors of AVE, and Mr. Solano and Mr. Miller executed noncompetition
agreements with Medtronic (which become effective only upon completion of the
Merger). On November 30, 1998, prior to the opening of trading on the New York
Stock Exchange ("NYSE") and the Nasdaq National Market, Medtronic and AVE issued
a joint press release announcing the execution of the Merger Agreement.
 
AVE'S REASONS FOR THE MERGER; RECOMMENDATION OF THE AVE BOARD OF DIRECTORS
 
    At the meeting of the AVE Board on November 29, 1998, the AVE Board
unanimously approved the Merger Agreement, the Stock Option Agreement, and the
other agreements related to the Merger. In reaching its determination, the AVE
Board considered the following material factors:
 
    - The opportunity the Merger affords the combined company to increase its
      presence in the interventional cardiovascular market, which should enable
      it to offer its customers a broader and more varied array of products and
      should also help to create an extensive intellectual property portfolio in
      the interventional products area;
 
    - The expectation that the combined company would be better positioned than
      either company on its own could be, to benefit from technological and
      other developments in the health care industry, which the AVE Board
      believes should result in the acceleration of product development and
      technological innovation;
 
    - The overall strategic fit between AVE and Medtronic in view of their
      respective product lines and the complementary businesses of AVE in
      interventional cardiology and Medtronic in the cardiac rhythm management,
      cardiac surgery, and neurological spinal surgery fields, which should
      result in or improve the combined company's ability to provide treatment
      on all aspects of cardiovascular diseases, to provide a wide array of
      cardiovascular and neurological therapies, and to meet the needs of
      physicians in catherization labs;
 
    - The advantages of combining two highly capable management teams, each with
      established track records. AVE's Board expects the health care industry to
      continue to be characterized by substantial uncertainty and the likelihood
      of continuing consolidation and believes that, by combining the expertise
      of AVE's and Medtronic's managements, the combined company should be
      better able to respond to these changes and to take advantage of the
      opportunities that these changes may create;
 
    - The potential revenue synergies offered by the Merger through the
      broadening of existing product lines of both companies;
 
    - The potential cost synergies offered by the Merger through consolidation
      and integration of certain distribution, sales, and administrative
      operations and functions; and
 
    - The changing health care environment and the increasing emphasis on cost
      containment, including the emergence of large managed care buying groups
      and hospital consolidations, which suggests to the AVE Board that a
      certain critical mass is required to compete effectively in the market and
      to absorb the pressures of the managed care structure. The AVE Board
      believes the Merger is integral to achieving the necessary critical mass.
 
    In addition to the factors set forth above, the AVE Board reviewed and
considered a wide variety of information relevant to the Merger, including:
 
                                       15
<PAGE>
    - The business, earnings, operations, financial condition, and prospects of
      Medtronic and AVE, both individually and on a combined basis, including,
      but not limited to, AVE's and Medtronic's respective recent and historic
      stock and earnings performance;
 
    - The amount and form of the consideration to be received by AVE
      shareholders in the Merger, the historical trading ranges of AVE common
      stock and Medtronic common stock, and the estimated future financial
      results of AVE and Medtronic;
 
    - AVE's strategic alternatives, including remaining a separate company and
      growing internally or through acquisitions, remaining a separate company
      for the near term while continuing to explore a future acquisition of AVE,
      or engaging in a merger of equals or joint venture transaction with
      another party, including certain risks involved in remaining a separate
      company such as the risks of being unable to meet or exceed projections
      and anticipated growth rates due to increasing competitive pressures in
      the markets for its products;
 
    - The opinion of SG Cowen rendered at the November 29, 1998 meeting of the
      AVE Board that, based upon and subject to the various assumptions and
      conditions set forth in that opinion, the Conversion Ratio was fair, from
      a financial point of view, to holders of AVE common stock as of November
      29, 1998;
 
    - The expectation that the Merger will not result in the payment of federal
      income tax for AVE and its shareholders and that the Merger will be
      accounted for as a pooling of interests;
 
    - The opportunity for AVE shareholders to receive a premium over the market
      price for their shares immediately prior to the announcement of the Merger
      (with the consideration to be received representing a premium of
      approximately 67% over the closing price of $32.375 per share of AVE
      common stock on the last trading day prior to the announcement of the
      Merger, if the average stock price per share of Medtronic common stock is
      between $61.20 and $74.80 on the date of the Merger);
 
    - The opportunity for AVE shareholders to continue equity participation in a
      larger, more diversified medical products enterprise and to share in the
      long-term growth of Medtronic following the Merger, if achieved;
 
    - The opportunity for AVE shareholders to receive future cash dividends with
      respect to their shareholdings;
 
    - The belief that the terms of the Merger Agreement, including the parties'
      representations, warranties, and covenants, and the conditions to their
      respective obligations, are reasonable; and
 
    - The impact of the Merger on AVE's customers and employees.
 
    The AVE Board also considered certain potentially negative factors in its
deliberations concerning the Merger, including, without limitation, the
following:
 
    - The possibility that the Merger would not be consummated following the
      execution of the Merger Agreement;
 
    - The risk that the combined company might not realize the anticipated cost
      savings and revenue synergies of the Merger;
 
    - The risk that the combined company would be unable to retain key
      employees;
 
    - The risk that the other benefits sought to be achieved by the Merger may
      not be achieved; and
 
    - The risk of intellectual property or other litigation associated with the
      activities of Medtronic.
 
    The AVE Board concluded that the benefits of the transaction to AVE and its
shareholders outweighed the risks associated with the foregoing factors.
 
                                       16
<PAGE>
    The above discussion of the information and factors considered by the AVE
Board is not all-inclusive but is believed to include all material factors
considered by the AVE Board. In view of the variety of factors considered by the
AVE Board, the AVE Board did not find it practicable to quantify or otherwise
attempt to assign relative weights to the specific factors considered in making
its determination. In addition, individual members of the AVE Board may have
given different weights to different factors. Consequently, the AVE Board did
not quantify the assumptions and results of its analysis in reaching its
determination that the Merger is fair to, and in the best interests of, AVE and
its shareholders.
 
    THE AVE BOARD BELIEVES THAT THE MERGER IS IN THE BEST INTERESTS OF AVE AND
ITS SHAREHOLDERS. THE AVE BOARD, THEREFORE, UNANIMOUSLY RECOMMENDS THAT ITS
SHAREHOLDERS VOTE FOR APPROVAL OF THE MERGER.
 
    See "The Merger--Background of the Merger," "--Opinion of AVE's Financial
Advisor," "--Certain Federal Income Tax Considerations," and "Comparative Stock
Prices and Dividends."
 
MEDTRONIC'S REASONS FOR THE MERGER
 
    Medtronic believes that the acquisition of AVE will considerably broaden and
strengthen Medtronic's market position in the interventional cardiology field
and will complement Medtronic's positions in the cardiac rhythm management,
cardiac surgery, and neurological and spinal surgery fields. Medtronic also
believes that the two companies' businesses are very complementary and offer
significant customer synergies without significant overlap or duplication in
product lines, which will enhance Medtronic's ability to fulfill its mission of
restoring patients to full and active lives.
 
OPINION OF AVE'S FINANCIAL ADVISOR
 
    AVE retained SG Cowen to serve as financial advisor to the AVE Board in
connection with any acquisition proposals that AVE might receive. As part of
this assignment, SG Cowen was asked to render an opinion to the AVE Board as to
the fairness, from a financial point of view, to the holders of AVE common stock
of the Conversion Ratio.
 
    On November 29, 1998, SG Cowen delivered certain of its written analyses and
its oral opinion to the AVE Board, subsequently confirmed in writing as of the
same date, to the effect that, subject to the various assumptions set forth
therein, as of November 29, 1998, the Conversion Ratio was fair, from a
financial point of view, to the holders of AVE common stock. THE FULL TEXT OF
THE WRITTEN OPINION OF SG COWEN, DATED NOVEMBER 29, 1998, IS ATTACHED HERETO AS
ANNEX B AND IS INCORPORATED BY REFERENCE. HOLDERS OF AVE COMMON STOCK ARE URGED
TO READ THE OPINION IN ITS ENTIRETY FOR THE ASSUMPTIONS MADE, PROCEDURES
FOLLOWED, OTHER MATTERS CONSIDERED AND LIMITS OF THE REVIEW BY SG COWEN. THE
SUMMARY OF THE WRITTEN OPINION OF SG COWEN SET FORTH HEREIN IS QUALIFIED IN ITS
ENTIRETY BY REFERENCE TO THE FULL TEXT OF SUCH OPINION. SG COWEN'S ANALYSES AND
OPINION WERE PREPARED FOR AND ADDRESSED TO THE AVE BOARD AND ARE DIRECTED ONLY
TO THE FAIRNESS, FROM A FINANCIAL POINT OF VIEW, OF THE CONVERSION RATIO AND DO
NOT CONSTITUTE AN OPINION AS TO THE MERITS OF THE MERGER OR A RECOMMENDATION TO
ANY SHAREHOLDER AS TO HOW TO VOTE ON THE PROPOSED MERGER. THE CONVERSION RATIO
WAS DETERMINED THROUGH NEGOTIATIONS BETWEEN AVE AND MEDTRONIC AND NOT PURSUANT
TO RECOMMENDATIONS OF SG COWEN.
 
    In arriving at its opinion, SG Cowen reviewed and considered such financial
and other matters as it deemed relevant, including, among other things:
 
    - the Merger Agreement dated November 29, 1998, provided to SG Cowen by AVE;
 
    - certain publicly available information for AVE, including each of the
      annual reports of AVE filed on Form 10-K for the fiscal years ended June
      30, 1996, 1997 and 1998 and the quarterly report on Form 10-Q for the
      fiscal quarter ended September 30, 1998, and certain other relevant
      financial and operating data for AVE furnished to SG Cowen by management
      of AVE;
 
    - certain publicly available information for Medtronic, including each of
      the annual reports of Medtronic filed on Form 10-K for the fiscal years
      ended April 30, 1996, 1997 and 1998, the
 
                                       17
<PAGE>
      quarterly report on Form 10-Q for the fiscal quarter ended July 31, 1998,
      and the unaudited financial statements for the fiscal quarter ended
      October 31, 1998, and certain other relevant financial and operating data
      for Medtronic furnished to SG Cowen by management of Medtronic;
 
    - discussions SG Cowen had with management and senior personnel of each of
      AVE and Medtronic concerning the historical and current business
      operations, financial conditions, and prospects of AVE and Medtronic and
      such other matters SG Cowen deemed relevant;
 
    - the reported price and trading histories of the shares of AVE common stock
      and Medtronic common stock as compared to the reported price and trading
      histories of certain publicly traded companies SG Cowen deemed relevant;
 
    - First Call consensus earnings per share estimates of financial
      institutions (the "First Call Estimates") for AVE and Medtronic,
      respectively, and financial projections provided in currently available
      Wall Street analyst reports (the "Analyst Projections") for AVE and
      Medtronic, respectively, including, among other things, the capital
      structure, sales, net income, cash flow, capital requirements, and other
      data of AVE and Medtronic SG Cowen deemed relevant;
 
    - discussions with management and senior personnel of AVE and Medtronic
      concerning the First Call Estimates and Analyst Projections;
 
    - based on the Analyst Projections, the potential pro forma financial
      effects of the Merger;
 
    - certain aspects of the respective financial conditions of AVE and
      Medtronic as compared to such aspects of the financial conditions of
      certain other companies SG Cowen deemed relevant;
 
    - certain financial terms of the Merger as compared to the financial terms
      of selected other business combinations SG Cowen deemed relevant; and
 
    - such other information, financial studies, analyses, and investigations
      and such other factors that SG Cowen deemed relevant for the purposes of
      its opinion.
 
    In conducting its review and arriving at its opinion, SG Cowen, with the AVE
Board's consent, assumed and relied, without independent investigation, upon the
accuracy and completeness of all financial and other information provided to SG
Cowen by AVE and Medtronic or which was publicly available, and SG Cowen did not
undertake any responsibility for the accuracy, completeness, or reasonableness
of, and did not independently verify, such information. In addition, SG Cowen
did not assume any obligation to conduct any physical inspection of the
properties or facilities of AVE or Medtronic. SG Cowen further relied upon the
assurance of management of AVE that they are unaware of any facts that would
make the information provided to SG Cowen by AVE or Medtronic or which was
publicly available (including, without limitation, the First Call Estimates and
Analyst Projections (including reports of SG Cowen research analysts))
incomplete or misleading in any respect. SG Cowen, with the AVE Board's consent,
assumed that the First Call Estimates and Analyst Projections (including reports
of SG Cowen research analysts) reviewed by SG Cowen provided a reasonable basis
for its opinion and indicated reasonable estimates of the future performance of
AVE and Medtronic, and SG Cowen relied upon such estimates and projections. SG
Cowen did not make or obtain any independent evaluations, valuations, or
appraisals of the assets or liabilities of AVE or Medtronic, nor was SG Cowen
furnished with such materials. With respect to all legal matters relating to AVE
and Medtronic, SG Cowen relied on the advice of legal counsel to AVE. AVE
informed SG Cowen of its expectation, and SG Cowen assumed, that the Merger (i)
will be recorded as a pooling-of-interests under generally accepted accounting
principles and (ii) will be treated as a tax-free reorganization within the
meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended.
 
    SG Cowen's opinion is necessarily based upon economic and market conditions
and other circumstances as they existed and could be evaluated by SG Cowen on
the date of its opinion. It should be understood that, although subsequent
developments may affect SG Cowen's opinion, SG Cowen does not
 
                                       18
<PAGE>
have any obligation to update, revise, or reaffirm its opinion, and SG Cowen
expressly disclaims any responsibility to do so. Without limiting the generality
of the foregoing, SG Cowen is not opining as to the effect of the consummation
of, or failure to consummate, the acquisition of Sofamor Danek Group, Inc. by
Medtronic. Additionally, SG Cowen was not authorized or requested to, and did
not, solicit alternative offers for AVE or its assets.
 
    SG Cowen's opinion does not constitute a recommendation to any shareholder
as to how such shareholder should vote with respect to the Merger or to take any
other action in connection with the Merger or otherwise. SG Cowen has not been
requested to opine as to, and SG Cowen's opinion does not in any manner address,
AVE's underlying business decision to effect the Merger. SG Cowen does not
express any opinion as to what the value of Medtronic common stock actually will
be when issued to AVE's shareholders pursuant to the Merger. Furthermore, SG
Cowen expresses no view as to the price or trading range for shares of AVE
common stock or Medtronic common stock following consummation of the Merger or
otherwise.
 
    For purposes of rendering its opinion, SG Cowen assumed, in all respects
material to its analysis, that the representations and warranties of each party
contained in the Merger Agreement are true and correct, that each party would
perform all of the covenants and agreements required to be performed by it under
the Merger Agreement and that all conditions to the consummation of the Merger
would be satisfied without waiver thereof. SG Cowen also assumed that all
governmental, regulatory, and other consents and approvals contemplated by the
Merger Agreement would be obtained and that in the course of obtaining any of
those consents no restrictions would be imposed or waivers made that would have
an adverse effect on the contemplated benefits of the Merger.
 
    The following is a summary of the principal financial analyses performed by
SG Cowen to arrive at its opinion. SG Cowen performed certain procedures,
including each of the financial analyses described below, and reviewed with the
management of AVE the assumptions on which such analyses were based and other
factors, including the historical and projected financial results of AVE and
Medtronic. No limitations were imposed by the AVE Board with respect to the
investigations made or procedures followed by SG Cowen in rendering its opinion.
 
    HISTORICAL EXCHANGE RATIO ANALYSIS.  SG Cowen analyzed the ratios of the
closing prices of AVE common stock to those of Medtronic common stock (the
"Historical Exchange Ratio") over certain periods ending November 25, 1998. Such
periods included the latest 12 months, latest six months, latest three months,
and the latest one month. Such analysis indicated that the mean Historical
Exchange Ratio for each of such periods was 0.635, 0.603, 0.597, and 0.470,
respectively, and that the Historical Exchange Ratio implied by the closing
stock prices for AVE common stock and Medtronic common stock on November 25,
1998 was 0.448. Such analysis also indicated that the high and low Historical
Exchange Ratios over the last 12 months were 0.840 and 0.433, respectively. SG
Cowen noted that the exchange ratio implied by Medtronic's offer, based on the
closing prices for AVE common stock and Medtronic common stock on November 25,
1998, is 0.776.
 
    ANALYSIS OF CERTAIN TRANSACTIONS.  SG Cowen reviewed the financial terms, to
the extent publicly available, of 12 selected transactions (collectively, the
"Selected Transactions") involving the acquisition of companies in the
cardiology industry with Equity or Enterprise Values (as defined below) greater
than $200 million, which were announced or completed since June 28, 1994. The
Selected Transactions consisted of (listed as acquiror/target): AVE/C.R. Bard -
Coronary Cath Lab Business; Medtronic/Physio-Control International Corporation;
Boston Scientific Corporation/Schneider Worldwide; Boston Scientific
Corporation/Target Therapeutics; Genzyme Corporation/Deknatel Snowden Pencer,
Inc.; Medtronic/ InStent, Inc.; St. Jude Medical, Inc./Daig Corporation; Johnson
& Johnson/Cordis Corp.; Boston Scientific Corporation/Meadox Medicals, Inc.;
Boston Scientific Corporation/Heart Technology, Inc.; Boston Scientific
Corporation/SCIMED Life Systems, Inc.; and St. Jude Medical, Inc./Siemens -
Pacesetter / Elema Cardiac Systems.
 
                                       19
<PAGE>
    SG Cowen reviewed the market capitalization of common stock plus total debt
less cash and equivalents ("Enterprise Value") paid in the Selected Transactions
as a multiple of latest reported 12 month ("LTM") revenues and also examined the
multiples of equity value paid in the Selected Transactions to book value,
tangible assets and LTM earnings. In addition, SG Cowen reviewed the premium of
the offer price over the trading prices one trading day and four weeks (that is,
20 trading days) prior to the announcement date of each Selected Transaction.
 
    Such analyses indicated that, (i) on the basis of the Enterprise Value paid,
the Selected Transactions had mean and median valuations of 5.82x and 3.97x LTM
revenues, respectively; (ii) on the basis of equity value paid, the Selected
Transactions had mean and median valuations of 6.84x and 6.03x book value, 5.59x
and 4.60x tangible assets and 26.7x and 28.6x LTM earnings, respectively; and
(iii) the mean and median premiums by which the offer prices exceeded the
closing stock prices one trading day and four weeks prior to announcement date
of the respective Selected Transactions were 22.5% and 19.6%, respectively, for
one trading day prior and 31.9% and 31.3%, respectively, for four weeks prior.
 
    The corresponding multiple of LTM revenues implied by Medtronic's offer is
5.47x times. The corresponding multiples of book value, tangible assets, and LTM
earnings implied by Medtronic's offer is 9.93x, 3.38x, and 25.0x, respectively.
In addition, Medtronic's offer represented premiums of 76.7% and 95.5%,
respectively, over the AVE common stock closing price one trading day and four
weeks prior to November 25, 1998.
 
    Although the Selected Transactions were used for comparison purposes, none
of such transactions is directly comparable to the Merger, and none of the
companies in such transactions (other than AVE and Medtronic) is directly
comparable to AVE or Medtronic. Accordingly, an analysis of the results of such
a comparison is not purely mathematical but instead involves complex
considerations and judgments concerning differences in historical and projected
financial and operating characteristics of the companies involved and other
factors that could affect the acquisition value of such companies or AVE to
which they are being compared.
 
    ANALYSIS OF CERTAIN PUBLICLY TRADED COMPANIES.  To provide contextual data
and comparative market information, SG Cowen compared selected historical
operating and financial data and ratios for AVE to the corresponding financial
data and ratios of certain other companies whose securities are publicly traded
and which SG Cowen believes have operating, market valuation and trading
valuations similar to what might be expected of AVE. These companies included:
Guidant Corporation, Boston Scientific Corporation, St. Jude Medical, Inc., and
Arrow International, Inc. (the "Selected Companies"). Such data and ratios
included the Enterprise Value of such Selected Companies as a multiple of LTM
revenues, and the market capitalization of common stock of such Selected
Companies as a multiple of the book value of common shareholders' equity. SG
Cowen also examined the ratios of the current prices of the Selected Companies
to the estimated 1999 calendar year earnings per share ("EPS") (as available
from SG Cowen research analyst reports or, if not so available, First Call) and
estimated EPS for the following (2000) calendar year (as estimated by First
Call) for these companies.
 
    Such analysis indicated that, for the Selected Companies, (i) the mean and
median values of Enterprise Value as a multiple of LTM revenue were 4.38x and
3.93x, respectively; (ii) the mean and median market capitalizations of common
stock as a multiple of the book value of common shareholders' equity were 11.06x
and 8.32x, respectively; and (iii) the mean and median prices per share as a
multiple of estimated EPS for the 1999 and 2000 calendar years were 21.5x and
20.2x, respectively, for the 1999 calendar year, and 20.6x and 20.9x,
respectively, for the 2000 calendar year.
 
    The corresponding multiple of LTM revenues for AVE implied by Medtronic's
offer is 5.47x. The corresponding multiple of market capitalization of common
stock as a multiple of the book value of common shareholders' equity for AVE
implied by Medtronic's offer is 9.93x. In addition, the corresponding multiples
of the estimated EPS for the 1999 and 2000 calendar years for AVE implied by
Medtronic's offer are 20.3x and 16.7x, respectively.
 
                                       20
<PAGE>
    Although the Selected Companies were used for comparison purposes, none of
such companies is directly comparable to AVE. Accordingly, an analysis of the
results of such a comparison is not purely mathematical but instead involves
complex considerations and judgments concerning differences in historical and
projected financial and operating characteristics of the Selected Companies and
other factors that could affect the public trading value of the Selected
Companies or AVE to which they are being compared.
 
    CONTRIBUTION ANALYSIS.  SG Cowen analyzed the respective contributions of
LTM revenues, EBIT and net income, and 1999 and 2000 calendar year estimated net
income of AVE and Medtronic, to the combined company based upon the historical
and projected financial results of AVE and Medtronic, based on SG Cowen research
analyst estimates for AVE and Medtronic. This analysis showed that AVE would
contribute to the combined company 20.2% of revenues, 23.1% of EBIT, and 18.9%
of net income on an LTM basis, and 18.3% and 18.5% of estimated net income for
the 1999 and 2000 calendar years, respectively.
 
    SG Cowen also noted that holders of AVE common stock would own approximately
9.9% of the combined company, assuming the Medtronic Average Stock Price for the
15 consecutive trading days ending on and including the second trading day
before the Special Meeting is $68.00 (the average closing stock price of
Medtronic common stock for the 10 trading days ended November 27, 1998).
 
    STOCK TRADING HISTORY.  To provide contextual data and comparative market
data, SG Cowen reviewed the historical market prices and trading volumes of AVE
common stock from April 3, 1996 (the first trading day of AVE common stock) to
November 25, 1998 and for the 12-month period ended November 25, 1998. SG Cowen
noted that over the indicated periods the high and low prices for shares of AVE
were $48.13 and $4.50, and $48.13 and $24.44, respectively. SG Cowen also
reviewed the historical market prices and trading volumes of Medtronic common
stock over the 12-month and three-year periods ended November 25, 1998. SG Cowen
noted that over the indicated periods the high and low prices for shares of
Medtronic were $72.75 and $45.44, and $72.75 and $22.25, respectively.
 
    The summary set forth above is not a complete description of all the
analyses performed by SG Cowen. The preparation of a fairness opinion involves
various determinations as to the most appropriate and relevant methods of
financial analyses and the application of these methods to the particular
circumstances and, therefore, such an opinion is not readily susceptible to
partial analysis or summary description. SG Cowen did not attribute any
particular weight to any analysis or factor considered by it, but rather made
qualitative judgments as to the significance and relevance of each analysis and
factor. Accordingly, notwithstanding the separate factors summarized above, SG
Cowen believes, and has advised the AVE Board, that its analyses must be
considered as a whole and that selecting portions of its analyses and the
factors considered by it, without considering all analyses and factors, could
create an incomplete view of the process underlying its opinion. In performing
its analyses, SG Cowen made numerous assumptions with respect to industry
performance, business and economic conditions and other matters, many of which
are beyond the control of AVE and Medtronic. These analyses performed by SG
Cowen are not necessarily indicative of actual values or future results, which
may be significantly more or less favorable than suggested by such analyses. In
addition, analyses relating to the value of businesses do not purport to be
appraisals or to reflect the prices at which businesses or securities may
actually be sold. Accordingly, such analyses and estimates are inherently
subject to uncertainty, being based upon numerous factors or events beyond the
control of the parties or their respective advisors. None of AVE, Medtronic, SG
Cowen or any other person assumes responsibility if future results are
materially different from those projected. As mentioned above, the analyses
supplied by SG Cowen and its opinion were among several factors taken into
consideration by the AVE Board in making its decision to enter into the Merger
Agreement and should not be considered as determinative of such decision.
 
    SG Cowen was selected by the AVE Board as its financial advisor, and to
render an opinion to the AVE Board, because SG Cowen is a nationally recognized
investment banking firm and because, as part of
 
                                       21
<PAGE>
its investment banking business, SG Cowen is continually engaged in the
valuation of businesses and their securities in connection with mergers and
acquisitions, negotiated underwritings, secondary distributions of listed and
unlisted securities, private placements, and valuations for corporate and other
purposes. SG Cowen currently is providing other financial services for AVE for
which it will receive customary fees. Societe Generale, the sole shareholder of
SG Cowen, and its affiliates, including SG Cowen, in the ordinary course of
business have from time to time provided, and in the future may continue to
provide, commercial and investment banking services to AVE, including serving as
a financial advisor on potential acquisitions and as an underwriter on equity
offerings, and have received and may in the future receive fees for the
rendering of such services. In particular, in April 1996, SG Cowen acted as lead
manager of AVE's initial public offering, and was selected to serve as
co-manager on a proposed offering which was subsequently withdrawn before a
registration statement was filed with the SEC. SG Cowen also acted as financial
advisor to AVE in connection with the acquisition by AVE of World Medical
Manufacturing Corporation, and received a fee for its services in connection
with that transaction. In addition, in the ordinary course of its business, SG
Cowen and its affiliates trade the equity securities of AVE and Medtronic for
their own account and for the accounts of their customers, and accordingly, may
at any time hold a long or short position in such securities.
 
    AVE has agreed to pay a fee to SG Cowen for its financial advisory services
provided in connection with the Merger, all of which is contingent upon
consummation thereof. If the Merger is consummated, SG Cowen will be entitled to
receive a transaction fee equal to approximately 0.33% of the aggregate
consideration paid to AVE shareholders in the Merger, payable upon consummation
of the Merger. Assuming the Medtronic Average Stock Price for the 15 consecutive
trading days ending on the second trading day before the Special Meeting is
between $61.20 and $74.80, such transaction fee is estimated to be approximately
$12 million. Additionally, AVE has agreed to reimburse SG Cowen for its
out-of-pocket expenses, including attorneys' fees, and has agreed to indemnify
SG Cowen against certain liabilities, including liabilities under the federal
securities laws. The terms of the fee arrangement with SG Cowen, which are
customary in transactions of this nature, were negotiated at arm's length
between AVE and SG Cowen, and the AVE Board was aware of such arrangement.
 
CONVERSION OF AVE COMMON STOCK IN THE MERGER
 
    At the Effective Time, if the Average Stock Price (as defined below) is
between $61.20 and $74.80, each outstanding share of AVE common stock will
convert automatically into the right to receive the number of shares of
Medtronic common stock (the "Conversion Ratio") equal to $54 divided by the
average of the daily closing sale prices of Medtronic common stock, as reported
on the NYSE Composite Tape (the "Average Stock Price"), for the 15 consecutive
trading days ending on and including the second trading day before the Special
Meeting. Any shares of AVE common stock held by Medtronic, its subsidiaries, or
AVE's subsidiaries will not be treated as outstanding, however, and will not
convert into Medtronic common stock.
 
    The Conversion Ratio described above applies if the Average Stock Price is
between $61.20 and $74.80. If the Average Stock Price is $61.20 or less,
however, the Conversion Ratio is 0.88235 of a Medtronic share. If the Average
Stock Price is $74.80 or more, the Conversion Ratio is 0.72193 of a Medtronic
share.
 
    If, prior to the Effective Time, Medtronic recapitalizes, splits, or
combines the Medtronic common stock or pays a stock dividend or other stock
distribution in shares of Medtronic common stock, then the Conversion Ratio will
be appropriately adjusted.
 
    Based on the number of shares of AVE common stock outstanding on the record
date (assuming a Conversion Ratio of [0.79266] of a Medtronic share for each AVE
share, calculated by using the [December 15], 1998 Medtronic closing sale price
of $[68.125] as the assumed Average Stock Price solely for illustrative purposes
of this paragraph), an estimated [51,096,727] shares of Medtronic common stock
 
                                       22
<PAGE>
will be issued in exchange for AVE common stock upon consummation of the Merger.
Such shares would represent approximately 9% of the shares of Medtronic common
stock that would be outstanding after consummation of the Merger.
 
    AVE shareholders should understand that, because the market price of
Medtronic common stock fluctuates, the market value of the Medtronic shares that
AVE shareholders will receive in the Merger (whether measured at the Effective
Time of the Merger or the date of the Special Meeting or another date) may be
less than or greater than the Average Stock Price used for purposes of
determining the Conversion Ratio. In addition, because the value of Medtronic
shares fluctuates, the market value of the Medtronic common stock that AVE
shareholders will receive in the Merger may increase or decrease following the
Merger. The maximum Conversion Ratio of 0.88235 (if the Average Closing Price of
Medtronic common stock is less than $61.20) means that, at the time of the
Merger, you may receive less than $54 in Medtronic common stock for each AVE
share you own. Similarly, the minimum Conversion Ratio of 0.72193 (if the
Average Closing Price is more than $74.80) means that you may receive more than
$54 in Medtronic common stock for each AVE share you own. In addition, the
Average Stock Price (which is calculated during a 15-day period ending on and
including the second trading day prior to the Special Meeting) could be
different from the closing price of Medtronic common stock at the time of the
Merger. See "Comparative Stock Prices and Dividends" for information regarding
the historical market prices of Medtronic common stock.
 
    FRACTIONAL SHARES
 
    Medtronic will not issue any certificates or scrip representing fractional
shares of Medtronic common stock in the Merger. All fractional shares of
Medtronic common stock that an AVE shareholder would otherwise receive in the
Merger will be aggregated, if and to the extent multiple AVE stock certificates
of such holder are submitted together to Norwest Bank Minnesota, N.A., the
exchange agent for the Merger (the "Exchange Agent"). If a fractional share
results from such aggregation, then, in lieu of any such fractional share, each
holder of AVE common stock who otherwise would be entitled to receive a
fractional share of Medtronic common stock in the Merger will receive an amount
of cash (without interest) determined by multiplying (1) the closing sale price
of Medtronic common stock on the date of the Merger by (2) the fractional share
interest of Medtronic common stock to which such holder would otherwise be
entitled.
 
    EXCHANGE OF AVE STOCK CERTIFICATES
 
    As soon as practicable after the Effective Time, the Exchange Agent will
mail a letter of transmittal to AVE shareholders. The letter of transmittal will
include instructions regarding the surrender of certificates representing shares
of AVE common stock in exchange for certificates representing shares of
Medtronic common stock.
 
    As soon as practicable after the Effective Time, the Exchange Agent will
distribute to holders of shares of AVE common stock, after those holders
surrender to the Exchange Agent the AVE stock certificates held by them for
cancellation, together with executed letters of transmittal, (1) one or more
certificates representing the number of whole shares of Medtronic common stock
into which the shares represented by the certificate(s) have been converted and
(2) a check in the amount of any cash in lieu of fractional shares. Holders of
AVE common stock will not receive interest on any cash received in the Merger.
 
    After the Effective Time, AVE stock certificates will evidence ownership of
the shares of Medtronic common stock into which they were converted. Holders of
AVE common stock will be entitled to any dividends that become payable to
persons who are holders of record of Medtronic common stock as of a record date
on or after the Effective Time, but only after they have surrendered their
certificates representing shares of AVE common stock for exchange. Any such
dividends will be paid to each AVE
 
                                       23
<PAGE>
shareholder entitled to them, without interest, at the time that such
certificates representing shares of AVE common stock are surrendered for
exchange, subject to any applicable abandoned property, escheat, or similar law.
Holders of AVE common stock will not be entitled, however, to dividends that
become payable before or after the Effective Time to persons who were holders of
record of Medtronic common stock as of a record date prior to the Effective
Time.
 
SHAREHOLDER RIGHTS PLANS
 
    Medtronic will not become an "Acquiring Person" and the Merger will not
cause a "Distribution Date" or a "Shares Acquisition Date" under AVE's Rights
Agreement, as amended by AVE on November 29, 1998, as those terms are defined in
that agreement. Under the terms of the AVE Rights Agreement, each outstanding
AVE Right (as defined in that agreement) will expire automatically pursuant to
the terms of the AVE Rights Agreement upon completion of the Merger and without
any action on the part of AVE shareholders.
 
    Each AVE shareholder entitled to receive shares of Medtronic common stock
pursuant to the Merger will receive, together with each share of Medtronic
common stock, one Medtronic Preferred Stock Purchase Right pursuant to the
Medtronic Shareholder Rights Plan. Such Right will be represented by the
certificate representing such share of Medtronic common stock. See "Comparison
of Rights of Medtronic and AVE Shareholders--Shareholder Rights Plans."
 
TREATMENT OF STOCK OPTIONS
 
    AVE's officers, directors, and employees hold outstanding options to
purchase shares of AVE common stock. All options held by certain employees of
AVE who are parties to certain employment agreements or vesting acceleration
agreements with AVE will either immediately become exercisable as of the
Effective Time or will become subject to immediate exercisability in the event
of certain changes in employment circumstances following the Merger, all as more
fully described in "--Interests of AVE's Directors and Officers in the Merger."
All other options granted under AVE's option plans will continue to vest at the
times stated in those plans. All options that are not exercised and remain
outstanding at the Effective Time will be assumed by Medtronic and, following
the Effective Time, will be exercisable upon the same terms and conditions as
such options were exercisable prior to the Merger, except that the exercise
price and the number of shares of Medtronic common stock that can be purchased
upon exercise of the options will be revised to reflect conversion of the
options on the same basis as shares of AVE common stock are converted into
shares of Medtronic common stock in the Merger. As promptly as practicable after
the Effective Time, Medtronic will provide to each holder of an AVE option a
written statement informing such holder of the assumption by Medtronic of such
option.
 
REPRESENTATIONS AND WARRANTIES
 
    In the Merger Agreement, AVE makes certain representations and warranties to
Medtronic regarding AVE and its subsidiaries, including as to: (1) their
corporate existence; (2) the authorization, execution, and enforceability of the
Merger Agreement and related agreements; (3) AVE's capital structure; (4) the
accuracy of AVE's recent SEC reports and financial statements; (5) the absence
of certain undisclosed material liabilities; (6) the absence of any need for
certain required third-party consents and other approvals; (7) compliance with
laws; (8) the absence of material litigation; (9) the absence of material
adverse changes between June 30 and November 29, 1998; (10) AVE's relations with
officers, directors, and employees; (11) certain tax matters; (12) the absence
of material violations of agreements; (13) the right to use intellectual
property; (14) AVE's benefit plans; (15) AVE's minute books; (16) the absence of
brokerage commissions, finder's fees, or other payments in connection with the
Merger; (17) the accuracy of information provided in connection with this Proxy
Statement/Prospectus; (18) the receipt of an opinion of SG Cowen as to the
fairness, from a financial point of view, to holders of AVE common stock of the
 
                                       24
<PAGE>
Conversion Ratio in the Merger; (19) the inapplicability of certain Delaware
antitakeover laws to the Merger; and (20) the accuracy of certain information.
 
    Medtronic and Merger Subsidiary also make certain representations and
warranties to AVE regarding Medtronic and Merger Subsidiary, including as to:
(1) their corporate existence; (2) the authorization, execution, and
enforceability of the Merger Agreement and related agreements; (3) the capital
structure of Medtronic and Merger Subsidiary; (4) the absence of any need for
certain required third-party consents and approvals; (5) the accuracy of
Medtronic's recent SEC reports and financial statements; (6) the legal
compliance and the accuracy of information contained in the Registration
Statement that includes this Proxy Statement/Prospectus; (7) the absence of
brokerage commissions, finder's fees, or other payments in connection with the
Merger; (8) the absence of certain undisclosed material liabilities; (9)
compliance with laws; (10) the absence of material litigation; (11) the absence
of material adverse changes between April 30 and November 29, 1998; (12) the
absence of actions by Medtronic that would prevent the Merger from constituting
a tax-free transaction; and (13) the accuracy of certain information.
 
CERTAIN COVENANTS BY AVE
 
    CONDUCT OF BUSINESS OF AVE PENDING THE MERGER.  With certain exceptions, AVE
has agreed that, prior to consummation of the Merger, unless Medtronic agrees
otherwise, to the extent commercially reasonable it will conduct its business
only in the ordinary course, keep substantially intact its business
organization, keep available its officers' and employees' services, and maintain
satisfactory relationships with third parties that are material to its business.
AVE also agreed that, among other things, it will not: amend its Certificate of
Incorporation or Bylaws; authorize, issue, sell, or pledge any stock or rights
to purchase stock (except that it can issue stock upon the exercise of
outstanding options and except that it can grant certain new options under
existing option plans to the extent that it does not jeopardize the parties'
ability to account for the Merger as a pooling of interests, and except that it
can grant rights and issue shares pursuant to its employee share purchase plan);
split, combine, or reclassify its stock; declare or pay any dividend or other
distribution; redeem or acquire any of its stock (with certain exceptions for
existing agreements and other circumstances that do not jeopardize the
accounting treatment of the Merger); change any material term of its outstanding
securities; create, incur, or assume any indebtedness other than in the ordinary
course of business; create, assume, or incur any material lien other than
intercompany indebtedness; increase or modify the compensation or benefits of
any of its directors, officers, or other employees (except under existing
agreements or in the ordinary course of business and consistent with past
practice or as required by law); sell or dispose of any material property other
than in the ordinary course of business; buy or agree to buy another business;
buy any assets, except under certain circumstances; enter into, materially
change, or terminate any material agreements, except as permitted by the Merger
Agreement or except in the ordinary course of business; materially change its
credit policies; materially alter its accounting principles; institute, settle,
or compromise any claim involving amounts in excess of a specified amount;
knowingly take any action that would cause any of its representations,
warranties, or agreements in the Merger Agreement to be inaccurate or breached
such that the closing conditions in the Merger Agreement will not be satisfied
as of the Closing Date; knowingly take any action that would jeopardize the
treatment of the Merger as a tax-free transaction; or agree to do any of the
things described above.
 
    ACCESS.  Pursuant to the Merger Agreement, AVE also agreed to give Medtronic
and its representatives access to AVE's offices, properties, books, and records;
to furnish to Medtronic and its representatives any financial and operating data
and other information that Medtronic may reasonably request; and to have its
employees and representatives cooperate with Medtronic in Medtronic's
investigation of the business of AVE.
 
    NO SOLICITATION OF COMPETING TRANSACTIONS.  AVE has agreed that (except as
is required by the fiduciary duties of AVE's directors) neither AVE nor any of
its representatives or affiliates will, directly or indirectly, solicit,
knowingly encourage, initiate, or participate in discussions or negotiations
with, or knowingly
 
                                       25
<PAGE>
provide any nonpublic information to, any person, entity, or group (other than
Medtronic) that proposes an alternative transaction with respect to AVE or any
subsidiary, or knowingly facilitate an alternative transaction. An "alternative
transaction" means a tender offer, exchange offer, merger, or similar
transaction, or a transaction or series of related transactions pursuant to
which a third party acquires more than 20% of the stock or assets of AVE and its
subsidiaries, except that the transaction with World Medical Manufacturing
Corporation is not an alternative transaction. AVE has agreed that it will
notify Medtronic promptly if it receives any such proposal.
 
    The AVE Board can, however, furnish information to or enter into
negotiations with a third party that makes an unsolicited superior proposal, but
only if (1) the AVE Board must do so to comply with its fiduciary duties to
shareholders imposed by law, (2) prior to doing so, AVE releases Medtronic from
certain standstill obligations, receives the same confidentiality and standstill
agreement from the third party, gives Medtronic all nonpublic information that
it gives to the third party, and gives written notice to Medtronic that it is
furnishing nonpublic information or entering into negotiations with the person
proposing the superior proposal, and (3) AVE keeps Medtronic informed of the
status of any negotiations. For these purposes, a "superior proposal" is a
proposal for an alternative transaction that the AVE Board reasonably and in
good faith determines is more favorable to AVE shareholders than the Merger.
 
CERTAIN COVENANTS BY MEDTRONIC
 
    CONDUCT OF BUSINESS OF MEDTRONIC PENDING THE MERGER.  Medtronic has agreed
that, prior to consummation of the Merger, unless AVE agrees otherwise, it will
not and will not permit any of its subsidiaries to: combine or reclassify its
stock; declare or pay any extraordinary dividend or other distribution (except
for stock splits in the form of stock dividends); redeem or acquire any of its
stock (other than pursuant to Medtronic's stock repurchase program or in such a
manner that the Merger is treated as a pooling of interests for accounting
purposes); change any material term of its securities; buy or agree to buy
another business, or sell or agree to sell any assets, if it could reasonably be
expected to delay or threaten the consummation of the Merger; alter its
accounting principles; knowingly take any action that would suspend trading of
Medtronic common stock on the NYSE; knowingly take any action that would cause
any of its representations, warranties, or agreements in the Merger Agreement to
be inaccurate or breached as of the Closing Date; knowingly take any action that
would jeopardize the treatment of the Merger as a tax-free transaction; or agree
to do any of the things described above.
 
    EMPLOYEE MATTERS.  Medtronic has agreed, to the extent practicable, to
provide employee benefits and programs to AVE employees that, in the aggregate,
are substantially comparable to or more favorable than those in existence as of
the date of the Merger Agreement. Medtronic has also agreed to honor all
employment and severance agreements and all severance, incentive and bonus plans
as in effect immediately prior to the Effective Time. AVE employees will be
credited with service accrued prior to the Effective Time for purposes of
employee benefit plans (including pension plans and retiree health plans),
subject to certain exceptions.
 
INTERESTS OF AVE'S DIRECTORS AND OFFICERS IN THE MERGER
 
    In considering the recommendation of the AVE Board with respect to the
Merger Agreement and the transactions contemplated by that agreement,
shareholders of AVE should be aware that certain members of the management and
Board of Directors of AVE have certain interests in the Merger that are in
addition to, and may be in conflict with, the interests of shareholders of AVE
generally. All such interests are described below, to the extent material, and
AVE believes that, except as described below, such persons do not have any
material interest in the Merger that is different from those of AVE shareholders
generally. The AVE Board was aware of, and considered the interests of, its
directors and officers when it approved the Merger Agreement and the Merger.
 
                                       26
<PAGE>
    EMPLOYMENT AND RELATED AGREEMENTS.  AVE has previously entered into
employment agreements with each of the following officers: Kevin Bedsole (Vice
President of International Sales), Greg French (Vice President of
Manufacturing), John Miller (Chief Financial Officer and Treasurer), John A.
Schiek (Vice President of Compliance), and Scott Solano (President, Chief
Executive Officer, and Chairman of the Board).
 
    The employment agreements of Messrs. French, Miller, Bedsole, and Schiek
provide that if, within two years after a "change of control," the officer's
employment involuntarily terminates (as defined in the employment agreement)
other than for cause, the officer will become entitled to receive a severance
payment equal to his aggregate annual salary and a continuation of benefits for
12 months. The employment agreements also provide that if the officer's
employment voluntarily terminates at any time after a "change of control," the
officer will be entitled to receive severance payments equal to one-half of his
annual salary. In addition, the employment agreements provide that upon a
"change of control," (i) all shares of AVE common stock that were granted to
such officers under restricted stock purchase agreements (and are therefore
subject to repurchase by AVE) will be released from any AVE repurchase options,
and (ii) all unvested stock options held by such officers will immediately
become vested and exercisable. The Merger constitutes a "change of control"
under such employment agreements. As of December 21, 1998, Messrs. French,
Bedsole, Miller, and Schiek held an aggregate (i) 354,063 shares of AVE common
stock subject to such repurchase option and (ii) no unvested options to purchase
shares of AVE common stock.
 
    The employment agreement with Mr. Solano provides that, subject to certain
limitations, if, within two years after a "change of control," Mr. Solano's
employment involuntarily terminates (as defined in the employment agreement)
other than for cause, (i) all of Mr. Solano's unvested stock options will
immediately become vested, subject to certain limitations, and (ii) Mr. Solano
will be entitled to receive a severance payment equal to his aggregate annual
salary and a continuation of his benefits for 12 months. The employment
agreement also provides that if Mr. Solano's employment is voluntarily
terminated for cause at any time after a "change of control," he will be
entitled to receive severance payments equal to one-half of his annual salary.
The Merger constitutes a "change of control" under Mr. Solano's employment
agreement. As of December 21, 1998, Mr. Solano held unvested options to purchase
an aggregate 180,000 shares of AVE common stock.
 
    CHANGE OF CONTROL VESTING ACCELERATION AGREEMENTS.  AVE has entered into
vesting acceleration agreements with certain key employees of AVE, including the
following officers: Lawrence Fassler (Vice President of Legal Affairs, General
Counsel and Secretary), Robert Harris (Vice President of Finance), Glenn Foley
(Vice President of Sales), and Andrew Rasdal (Vice President of Marketing).
Pursuant to such agreements, and subject to certain limitations, if, within one
year after a "change of control," such officer's employment is involuntarily
terminated (as defined in the vesting acceleration agreements) or such officer
terminates his employment for certain reasons (as described in the vesting
acceleration agreements), all unvested stock options held by such officer will
immediately become vested and exercisable. The Merger constitutes a "change of
control" under the vesting acceleration agreements. As of December 21, 1998,
Messrs. Fassler, Foley, Rasdal, and Harris held unvested options to purchase an
aggregate 265,209 shares of AVE common stock.
 
    1996 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN.  The Merger will cause the
acceleration of vesting of outstanding stock options under the 1996 Non-Employee
Directors' Stock Option Plan (the "Directors' Plan"). All such options will
terminate if not exercised at or prior to the Effective Time. As of December 21,
1998, non-employee directors of AVE held options to purchase an aggregate 44,000
shares of AVE common stock at a weighted average price of $25.53 per share (at
exercise prices ranging from $18.00 to $36.25 per share).
 
                                       27
<PAGE>
    INDEMNIFICATION.  Pursuant to the Merger Agreement, Medtronic has agreed
that, after the Effective Time of the Merger, it will provide certain
indemnification and liability insurance benefits to certain indemnified parties,
including directors and executive officers of AVE. See "--Indemnification."
 
VOTING AGREEMENTS
 
    Pursuant to voting agreements between Medtronic and all of the executive
officers and directors of AVE who own stock or options to acquire stock of AVE
(Kevin Bedsole, George Borkow, Mark Brister, Creg Dance, Craig Dauchy, Lawrence
Fassler, Glenn Foley, Gregory French, Robert Harris, Richard Klein, John Miller,
Azin Parhizgar, Andrew Rasdal, John Schiek, Scott Solano, Scott Wade, and Peter
Walsh), such individuals have agreed to vote all of the outstanding shares of
AVE common stock beneficially owned by them on the record date in favor of the
approval, consent, and ratification of the Merger. Nothing in the voting
agreements restricts or limits the right of a shareholder or optionholder to act
in his or her capacity as an officer or director of AVE consistent with his or
her fiduciary obligations. The voting agreements terminate upon termination of
the Merger Agreement. As of the record date, the shareholders who executed the
voting agreements beneficially owned an aggregate [4,851,049] outstanding shares
of AVE common stock, representing approximately [7.5]% of the AVE common stock
outstanding on the record date.
 
STOCK OPTION AGREEMENT
 
    Simultaneously with the execution of the Merger Agreement, AVE and Medtronic
entered into a Stock Option Agreement pursuant to which AVE granted to Medtronic
an option, exercisable only under certain specified circumstances, to purchase
12,807,795 shares of AVE common stock (which equaled 19.9% of the shares of AVE
common stock outstanding on the date of the Merger Agreement), at an exercise
price of $54 per share. The option is exercisable at any time following the
occurrence of an Exercise Event (as defined below) up to the earlier of (i) the
Effective Time, (ii) one year after the termination of the Merger Agreement
under certain circumstances or (iii) a termination of the Merger Agreement in
such a manner that a fee cannot become payable by AVE. Each of the termination
events described in "--Amendment and Termination of the Merger Agreement;
Effects of Termination" that could obligate AVE to pay a termination fee
pursuant to the Merger Agreement constitutes an "Exercise Event," except that a
termination by either company because (i) the AVE shareholders do not vote to
improve the Merger, (ii) a proposal for an alternative transaction (as defined
above) is announced prior to the failure to approve the Merger, and (iii) AVE
enters into an agreement for an alternative transaction within 12 months after
termination of the Merger Agreement with a third party, constitutes an Exercise
Event even if AVE does not consummate an alternative transaction with the same
third party that entered into such definitive agreement within two years after
entering into the agreement for an alternative transaction, as would be required
to trigger a termination fee under the Merger Agreement.
 
    If and when Medtronic's option under the Stock Option Agreement becomes
exercisable, Medtronic also has the right, which it can exercise in lieu of
exercising Medtronic's option, to require AVE to pay to Medtronic, in
cancellation of Medtronic's option, a cancellation amount equal to (a) the
greater of (1) the excess, if any, over the option price of the greater of (A)
the last sale price of a share of AVE common stock on the last trading day prior
to notice of exercise, (B) the highest price per share of AVE common stock
offered or paid in connection with an alternative transaction, and (C) in the
case of an alternative transaction structured as an asset acquisition, the
highest net consideration to be distributed to the AVE shareholders in any such
transaction or proposed transaction after other payments and deductions
(including the payment of all indebtedness of AVE that is not assumed), divided
by the number of shares of AVE common stock then outstanding on a fully-diluted
basis; and (2) $150 million divided by the initial number of shares subject to
the option, multiplied by (b) the number of shares then covered by the option.
The sum of such cancellation amount, the termination fee paid under the Merger
Agreement, and certain other amounts that Medtronic could receive if it
exercises the option and sells the AVE shares it acquires,
 
                                       28
<PAGE>
can never, however, exceed $150 million. See "--Amendment and Termination of the
Merger Agreement; Effects of Termination."
 
CONDITIONS TO CONSUMMATION OF THE MERGER; WAIVER
 
    The respective obligations of Medtronic, Merger Subsidiary, and AVE to
effect the Merger are subject to the satisfaction at or prior to the Merger of
certain conditions, including, among others: (a) the approval by the AVE
shareholders of the Merger; (b) the effectiveness of the Registration Statement;
(c) the expiration or termination of the waiting periods applicable to the
consummation of the Merger under the HSR Act and any foreign merger laws; (d)
the shares of Medtronic common stock issuable in the Merger having been duly
authorized for listing by the NYSE, subject to official notice of issuance; and
(e) the absence of an order, decree, or injunction by any court that makes the
Merger illegal or prohibits consummation of the Merger.
 
    In addition, the obligations of Medtronic and Merger Subsidiary to effect
the Merger are subject to the satisfaction at or prior to the Merger of certain
conditions, including that: (a) AVE has performed in all material respects its
obligations under the Merger Agreement required to be performed by it; (b) each
representation and warranty of AVE contained in the Merger Agreement shall have
been, without regard to any "material adverse effect" qualifications, true and
correct as of the date of Merger Agreement except for (i) those representations
and warranties that address matters only as of the date of the Merger Agreement
or another particular date, which representations and warranties shall be true
and correct as of such date, and (ii) except for any inaccuracies that do not
have a material adverse effect on AVE; (c) Medtronic has received letters from
PricewaterhouseCoopers LLP and Ernst & Young LLP, dated the Closing Date and
addressed to Medtronic and AVE, that as of such date no conditions exist that
would prevent Medtronic from accounting for the Merger as a pooling of interests
(the "Pooling Letters"); and (d) neither the Chief Executive Officer nor a
majority of the other executive officers of AVE shall have terminated their
employment with AVE after the Merger.
 
    In addition, the obligations of AVE to effect the Merger are subject to the
satisfaction at or prior to the Merger of certain conditions, including that:
(a) Medtronic and Merger Subsidiary have performed in all material respects
their obligations under the Merger Agreement required to be performed by them;
(b) each representation and warranty of Medtronic contained in the Merger
Agreement shall have been, without regard to any "material adverse effect"
qualifications, true and correct as of the date of Merger Agreement except for
(i) those representations and warranties that address matters only as of the
date of the Merger Agreement or another particular date, which representations
and warranties shall be true and correct as of such date, and (ii) except for
any inaccuracies that do no have a material adverse effect on Medronic; (c) AVE
has received the Pooling Letters; and (d) AVE has received an opinion of Cooley
Godward LLP, to the effect that the Merger will constitute a "tax-free"
reorganization for federal income tax purposes, and that opinion will not have
been withdrawn or materially changed. See "The Merger-- Certain Federal Income
Tax Consequences."
 
    Either Medtronic or AVE may waive any failure to comply with any obligation,
covenant, agreement, or condition in the Merger Agreement that is for the
benefit of that party. Any waivers granted by Medtronic are conclusively binding
on Merger Subsidiary.
 
    AVE cannot terminate the Merger Agreement due to any material adverse change
to Medtronic's business or operation, and AVE would be required to proceed with
the Merger even if any such material adverse change to Medtronic's business or
operations occurs (provided all of the conditions to AVE's obligation to
consummate the Merger are satisfied). AVE also would be required to proceed with
the Merger even if the average closing price of Medtronic common stock dropped
below $61.20 per share and the value per share of AVE common stock accordingly
dropped below $54 per share.
 
                                       29
<PAGE>
AMENDMENT AND TERMINATION OF THE MERGER AGREEMENT; EFFECTS OF TERMINATION
 
    Any of the provisions of the Merger Agreement may be amended by written
agreement of the respective parties at any time prior to the Effective Time of
the Merger. After approval of the Merger by the AVE shareholders, however, no
amendment may be made that reduces the amount or changes the type of
consideration into which each share of AVE common stock converts upon
consummation of the Merger.
 
    Even if the AVE shareholders approve the Merger, the Boards of Directors of
Medtronic and AVE can agree at any time to terminate the Merger Agreement
without completing the Merger.
 
    In addition, either company can terminate the Merger Agreement if:
 
    - the Merger is not completed by May 31, 1999 (or, if the companies receive
      requests for additional information from regulatory agencies, October 31,
      1999), except that neither company can terminate the Merger Agreement if
      its own breach is the reason the Merger has not been completed, or
 
    - a final court or governmental order prohibits the Merger, or
 
    - the AVE shareholders do not approve the Merger, or
 
    - the other company has materially breached its representations, warranties,
      or obligations under the Merger Agreement such that the conditions to
      Closing will not be satisfied. If the breach is curable by the breaching
      company before May 31, 1999 or October 31, 1999, as applicable, the non-
      breaching company cannot terminate the Merger Agreement as long as the
      breaching company is exercising its reasonable best efforts to cure the
      breach.
 
    Medtronic can terminate the Merger Agreement if:
 
    - the AVE Board materially breaches its obligations to not encourage,
      solicit, discuss, or negotiate with anyone else any alternative
      transaction, or
 
    - the AVE Board recommends, approves, accepts, or enters into an agreement
      regarding an alternative transaction, or
 
    - the AVE Board withdraws or modifies its recommendation of the Merger in a
      manner adverse to Medtronic, or
 
    - a third party makes a tender offer or exchange offer for AVE common stock,
      and the AVE Board either takes no position or does not recommend against
      acceptance of the offer within 10 business days.
 
    AVE can terminate the Merger Agreement if:
 
    - AVE has not breached the Merger Agreement, and
 
    - in order to comply with its fiduciary duties, the AVE Board is required to
      authorize, and does authorize, AVE to enter into an agreement regarding a
      transaction that the AVE Board reasonably and in good faith determines is
      more favorable to the AVE shareholders than the Merger with Medtronic, and
      AVE notifies Medtronic in writing that it intends to enter into such
      agreement, and
 
    - Medtronic does not make a new offer within 10 business days that the AVE
      Board determines is at least as favorable to the AVE shareholders, and
 
    - AVE pays the termination fee described below as requested by Medtronic.
 
    AVE has agreed to pay Medtronic a termination fee of $135 million if any of
the following occurs:
 
        the Merger Agreement is terminated by Medtronic because:
 
       - the AVE Board materially breaches its obligations to not encourage,
         solicit, discuss, or negotiate with anyone else any alternative
         transaction, or
 
       - the AVE Board recommends, approves, accepts, or enters into an
         alternative transaction, or
 
                                       30
<PAGE>
       - the AVE Board withdraws or modifies in a manner materially adverse to
         Medtronic its recommendation of the Merger, or
 
       - a third party makes a tender offer or exchange offer for AVE stock, and
         the AVE Board, within 10 business days, either takes no position or
         does not recommend against acceptance of the offer, or
 
        the Merger Agreement is terminated by AVE because:
 
       - in order to comply with its fiduciary duties, the AVE Board is required
         to authorize, and does authorize, AVE to enter into an agreement
         regarding a transaction that constitutes a superior proposal and
         Medtronic does not, within 10 business days of notice of the superior
         proposal, make an offer that the AVE Board, reasonably and in good
         faith after consultation with its financial and legal advisors,
         determines is at least as favorable to AVE shareholders, or
 
        the Merger Agreement is terminated by either company because:
 
       - the requisite vote of AVE shareholders is not obtained and a proposal
         for a competing transaction has been announced prior to the failure to
         approve the Merger, AVE enters into an agreement for a competing
         transaction within 12 months after termination of the Merger Agreement,
         and AVE consummates a competing transaction within two years after
         entering into the agreement for a competing transaction.
 
EXPENSES AND FEES
 
    Whether or not the Merger is consummated, all out-of-pocket expenses
incurred in connection with the Merger (including but not limited to accounting
and legal fees) and the transactions contemplated thereby will be paid by the
party incurring such costs and expenses, except that Medtronic and AVE will
share equally all expenses related to filing and printing the Registration
Statement and this Proxy Statement/Prospectus, and the filing fees required
under the HSR Act and any foreign merger laws.
 
    Goldman, Sachs & Co. provided certain financial advisory services to
Medtronic in connection with the Merger, for which Medtronic has agreed to pay a
fee of $14 million.
 
RESTRICTIONS ON RESALE OF MEDTRONIC COMMON STOCK
 
    The Medtronic common stock issuable in connection with the Merger has been
registered under the Securities Act and will be freely transferable by the
recipients, except that this registration does not cover resales by shareholders
of AVE who may be deemed to control or be under common control with AVE at the
time of the Special Meeting ("Affiliates"). Affiliates may not sell their shares
of Medtronic common stock acquired in connection with the Merger except pursuant
to an effective registration statement under the Securities Act covering such
shares, or in compliance with Rule 145 under the Securities Act or another
applicable exemption from the registration requirements of the Securities Act.
AVE has delivered to Medtronic, and agreed to update as necessary, a list
identifying all persons who, in AVE's opinion, upon advice of counsel, are
Affiliates of AVE for purposes of Rule 145. AVE has delivered to Medtronic from
each person already identified as an Affiliate, and has agreed to use all
reasonable efforts to cause each person who is subsequently identified as an
Affiliate to deliver to Medtronic at or prior to the Effective Time, an
agreement that such persons (1) will not offer to sell, sell, or otherwise
dispose of any shares of Medtronic common stock received in the Merger in
violation of the Securities Act, and (2) will not sell, transfer, pledge,
dispose of, or otherwise reduce such person's risk relative to Medtronic common
stock or AVE common stock during the period commencing 30 days prior to the
Effective Time of the Merger and ending at such time as Medtronic publishes
financial results covering at least 30 days of post-Merger combined operations.
It is expected that, after the period described in clause (2) above, Affiliates
will be able to sell such shares without registration and in accordance with the
volume, manner of sale, and other applicable limitations of the Securities Act
and the rules and regulations of the SEC thereunder.
 
                                       31
<PAGE>
    It is estimated that Affiliates of AVE will receive a maximum of
approximately 4,315,945 shares of Medtronic common stock upon consummation of
the Merger (assuming full exercise of all outstanding AVE options held by such
Affiliates and assuming a Conversion Ratio of [0.79266]). Such shares would
constitute less than 1% of the total number of shares of Medtronic common stock
anticipated to be outstanding immediately after the Effective Time after giving
effect to the shares issued pursuant to the Merger. Solely for illustrative
purposes of the foregoing estimate, the Conversion Ratio was calculated by using
the [December 15], 1998 Medtronic closing sale price of $[68.125] as the assumed
Average Stock Price. See "The Merger--Conversion of AVE Common Stock in the
Merger."
 
DEREGISTRATION OF AVE COMMON STOCK
 
    If the Merger is consummated, the AVE common stock will cease to be quoted
on the Nasdaq National Market, and Medtronic will apply to the SEC for the
deregistration of AVE common stock under the Exchange Act.
 
ACCOUNTING TREATMENT OF THE MERGER
 
    Medtronic intends to account for the Merger as a pooling of interests for
accounting and financial reporting purposes under generally accepted accounting
principles. This means the companies will be treated as if they had always been
combined for accounting and financial reporting purposes. Under the pooling of
interests method, the recorded assets and liabilities of the companies are
carried forward to the combined corporation at their recorded amounts and the
income (loss) of the companies constitutes the income (loss) of the combined
corporation for the entire fiscal period in which the combination occurs as well
as for prior fiscal periods. It is a condition to the obligations of Medtronic,
Merger Subsidiary, and AVE to consummate the Merger that Medtronic and AVE shall
have received the following: (1) a letter from Ernst & Young LLP, AVE's
independent accountants, dated the closing date, stating that, based upon
discussions with certain AVE officials and information furnished to Ernst &
Young LLP, no conditions exist related to AVE that would preclude Medtronic from
accounting for the Merger as a pooling of interests business combination, and
(2) a letter from PricewaterhouseCoopers LLP, Medtronic's independent
accountants, dated the closing date, confirming that the Merger will qualify as
a pooling of interests.
 
CERTAIN FEDERAL INCOME TAX CONSEQUENCES
 
    The following is a discussion of certain material United States federal
income tax consequences of the Merger. This discussion merely summarizes certain
principal United States federal income tax consequences of the Merger and is not
a complete analysis of all of the potential tax effects relevant to the Merger.
In this regard, this discussion does not deal with all federal income tax
considerations that may be relevant to certain AVE shareholders in light of
their particular circumstances, or to shareholders subject to special rules
under United States federal income tax law, including dealers in securities,
shareholders who do not hold their AVE common stock as capital assets, foreign
persons, tax-exempt entities, banks, insurance companies, shareholders who hold
their shares as a hedge or as part of a hedging, straddle, conversion, or other
risk reduction transaction, or persons who are subject to the alternative
minimum tax provisions of the Internal Revenue Code (the "Code"). Furthermore,
it does not address AVE shareholders who acquired their shares in connection
with stock options or stock purchase plans or in other compensatory
transactions. It also does not address the tax consequences of the Merger under
foreign, state, or local tax laws.
 
    AVE SHAREHOLDERS ARE URGED TO CONSULT THEIR OWN TAX ADVISORS AS TO THE
CONSEQUENCES OF THE MERGER, INCLUDING THE APPLICABLE FEDERAL, STATE, LOCAL, AND
FOREIGN TAX CONSEQUENCES TO THEM.
 
    Cooley Godward LLP, counsel to AVE, has rendered an opinion to AVE and
Fredrikson & Byron, P.A., counsel to Medtronic, has rendered an opinion to
Medtronic (collectively, the "Tax Opinions") that the Merger will constitute a
reorganization under Section 368 of the Code, and that each of AVE,
 
                                       32
<PAGE>
Medtronic and Merger Subsidiary will be a party to such reorganization. Neither
AVE nor Medtronic will request a ruling from the Internal Revenue Service (the
"IRS") with regard to any of the United States federal income tax consequences
of the Merger. The Tax Opinions are based on and subject to certain assumptions
and limitations as well as factual representations received from AVE and
Medtronic, as discussed below. An opinion of counsel represents only counsel's
best legal judgment and has no binding effect or official status of any kind. No
assurance can be given that contrary positions may not be taken by the IRS or a
court considering the issues.
 
    Subject to the assumptions, limitations, and qualifications described in the
Tax Opinions and in this discussion, it is the opinion of Cooley Godward LLP and
Fredrikson & Byron, P.A. that the material United States federal income tax
consequences of the Merger can be summarized as follows:
 
    - AVE, Medtronic, and Merger Subsidiary will not recognize gain or loss
      solely as a result of Medtronic's issuance of Medtronic common stock to
      the AVE shareholders in the Merger and the transfer by operation of law of
      Merger Subsidiary's assets and liabilities to AVE pursuant to the Merger;
 
    - AVE's shareholders will not recognize gain or loss upon their receipt in
      the Merger of Medtronic common stock in exchange for their shares of AVE
      common stock, except to the extent of cash received in lieu of a
      fractional share of Medtronic common stock;
 
    - The aggregate tax basis of Medtronic common stock received in the Merger
      will be the same as the aggregate tax basis of the AVE common stock
      surrendered in exchange for the Medtronic common stock (reduced by any
      amount of tax basis allocable to a fractional share interest in Medtronic
      common stock for which cash is received);
 
    - The holding period of each share of Medtronic common stock received by an
      AVE shareholder in the Merger will include the period during which such
      AVE shareholder held his or her AVE common stock surrendered in exchange
      therefor; and
 
    - Cash payments in lieu of a fractional share will be treated as if a
      fractional share of Medtronic common stock had been issued in the Merger
      and then redeemed by Medtronic, and capital gain or loss generally should
      be recognized by an AVE shareholder in respect of such payment equal to
      the difference (if any) between the amount of cash received and such
      shareholder's allocable tax basis in the fractional share (which will be a
      pro rata portion of the shareholder's tax basis in the Medtronic common
      stock received in the Merger).
 
    LIMITATIONS ON OPINION AND DISCUSSION.  As noted earlier, the Tax Opinions
are subject to certain assumptions, relating to, among other things, the truth
and accuracy of certain representations made by AVE and Medtronic, and the
consummation of the Merger in accordance with the terms of the Merger Agreement
and applicable state law. Furthermore, the Tax Opinions will not bind the IRS
and, therefore, the IRS is not precluded from asserting a contrary position. The
Tax Opinions and this discussion are based on currently existing provisions of
the Code, existing and proposed Treasury regulations, and current administrative
rulings and court decisions. There can be no assurance that future legislative,
judicial, or administrative changes or interpretations will not adversely affect
the accuracy of the Tax Opinions or of the statements and conclusions set forth
herein. Any such changes or interpretations could be applied retroactively and
could affect the tax consequences of the Merger.
 
    A successful IRS challenge to the tax-free status of the Merger would result
in significant adverse tax consequences to the AVE shareholders. An AVE
shareholder would recognize gain or loss with respect to each share of AVE
common stock surrendered equal to the difference between the shareholder's basis
in such share and the fair market value, as of the Effective Time of the Merger,
of the Medtronic common stock received in exchange for such AVE common stock and
cash received in lieu of a fractional share of Medtronic common stock. In such
event, a shareholder's aggregate basis in the Medtronic common stock
 
                                       33
<PAGE>
so received would equal its fair market value, and the shareholder's holding
period for such stock would begin the day after the closing date of the Merger.
 
    Certain noncorporate AVE shareholders may be subject to backup withholding
at a rate of 31% on cash payments received in lieu of a fractional share of
Medtronic common stock. Backup withholding will not apply, however, to a
shareholder who furnishes a correct taxpayer identification number and certifies
that he or she is not subject to backup withholding on the substitute Form W-9
included in the letter of transmittal, who provides a certificate of foreign
status on Form W-8, or who is otherwise exempt from backup withholding. A
shareholder who fails to provide the correct taxpayer identification number on
Form W-9 may be subject to a $50 penalty imposed by the IRS.
 
    Each AVE shareholder will be required to retain records and file with such
holder's U.S. federal income tax return a statement setting forth certain facts
relating to the Merger.
 
INDEMNIFICATION
 
    Under the Merger Agreement, Medtronic has agreed to continue to indemnify
the present and former officers and directors of AVE for a period of at least
six years following the Merger with respect to acts or omissions occurring prior
to the Effective Time, to the extent that they are currently indemnified under
AVE's Certificate of Incorporation, Bylaws, and indemnification agreements as of
the date of the Merger Agreement. Medtronic has also agreed to provide
directors' and officers' liability insurance coverage, comparable to that
currently maintained by AVE, for six years after the Effective Time. See "The
Merger--Interests of AVE's Directors and Officers in the Merger."
 
REGULATORY REQUIREMENTS
 
    Under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (the "HSR
Act"), certain acquisition transactions, including the Merger, cannot be
consummated unless certain information has been furnished to the Federal Trade
Commission ("FTC") and the Antitrust Division of the United States Department of
Justice ("Antitrust Division") and certain waiting period requirements have been
satisfied. Medtronic and AVE each furnished such information on December 8,
1998. Pursuant to the HSR Act, the Merger cannot be completed until at least 30
days after the parties furnished the required information, unless the FTC and
the Antitrust Division terminate the waiting period earlier. If the parties
receive any requests for additional information relating to their filings, those
requests will extend the waiting period until 20 days after the companies
substantially comply with any such request. It is possible, therefore, that the
necessary waiting periods may not expire until after the Special Meeting is held
and the AVE shareholders vote on the Merger.
 
    The Antitrust Division and the FTC frequently scrutinize the legality under
the antitrust laws of transactions such as the Merger. At any time before or
after the consummation of the Merger, the Antitrust Division or the FTC could
take any action under the antitrust laws that it deems necessary or desirable in
the public interest, including seeking to enjoin the consummation of the Merger
or seeking the divestiture of substantial assets of AVE or Medtronic. AVE and
Medtronic believe that the Merger will not violate the antitrust laws. There can
be no assurance, however, that a challenge to the Merger on antitrust grounds
will not be made or, if such a challenge is made, what the results will be.
 
    Due to the international scope of Medtronic's and AVE's businesses,
regulatory filings may also be required in certain European and other
jurisdictions. Medtronic and AVE are in the process of determining whether any
such filings will be required, but they do not expect any such filings to affect
the expected timing of the Merger.
 
    Other than as described in this Proxy Statement/Prospectus, the Merger does
not require the approval of any federal, state, or other agency. See "The
Merger--Conditions to Consummation of the Merger; Waiver."
 
                                       34
<PAGE>
NO DISSENTERS' RIGHTS
 
    Under Delaware law, AVE shareholders are not entitled to dissenters' rights
in connection with the Merger. Medtronic shareholders are also not entitled to
dissenters' rights in connection with the Merger.
 
                     COMPARATIVE STOCK PRICES AND DIVIDENDS
 
    Medtronic common stock is listed and traded on the New York Stock Exchange
(symbol: MDT), and it is a condition to all parties' obligations to consummate
the Merger that the Medtronic common stock to be issued in the Merger be
approved for such listing. AVE common stock is traded on the Nasdaq National
Market (symbol: AVEI).
 
    The following table sets forth, for the quarters indicated, the high and low
sales prices per share of Medtronic common stock on the NYSE and the cash
dividends paid per share of Medtronic common stock. Also set forth, for the
calendar period indicated, are the high and low sales prices per share of AVE
common stock as reported by the Nasdaq National Market.
 
<TABLE>
<CAPTION>
                                                                                                     AVE
                                                             MEDTRONIC COMMON STOCK              COMMON STOCK
                                                       -----------------------------------  ----------------------
                                                          HIGH        LOW       DIVIDENDS      HIGH        LOW
                                                       ----------  ----------  -----------  ----------  ----------
<S>                                                    <C>         <C>         <C>          <C>         <C>
CALENDAR 1996
First Quarter........................................  $  31.3125  $  22.25     $   .0325       *           *
Second Quarter.......................................  $  29.875   $  24.375    $   .0325   $  24.75    $  14.75
Third Quarter........................................  $  32.4375  $  23.50     $   .0475   $  18.125   $   9.125
Fourth Quarter.......................................  $  34.9375  $  30.25     $   .0475   $  14.5625  $   4.50
 
CALENDAR 1997
First Quarter........................................  $  35.875   $  28.8125   $   .0475   $   9.625   $   5.75
Second Quarter.......................................  $  44.4375  $  30.375    $   .0475   $  16.125   $   6.125
Third Quarter........................................  $  49.25    $  42.50     $   .055    $  28.6875  $  15.1875
Fourth Quarter.......................................  $  52.75    $  40.5625   $   .055    $  33.25    $  21.00
 
CALENDAR 1998
First Quarter........................................  $  58.25    $  45.4375   $   .055    $  45.375   $  24.4375
Second Quarter.......................................  $  66.00    $  47.9375   $   .055    $  41.375   $  28.00
Third Quarter........................................  $  72.75    $  51.00     $   .065    $  48.125   $  32.00
Fourth Quarter (through [December 15])...............  $  71.75    $  48.375    $   .065    $  52.125   $  27.125
</TABLE>
 
- ------------------------
 
*    AVE did not trade publicly until April 3, 1996, the initial public offering
     date of AVE common stock.
 
    AVE has never paid cash dividends. Under the Merger Agreement, AVE has
agreed not to pay any dividends on AVE common stock prior to the Merger.
Medtronic has paid regular quarterly cash dividends on Medtronic common stock
since 1978. It is expected that the Board of Directors of Medtronic will
continue the practice of declaring cash dividends on a quarterly basis; however,
no assurance can be given as to the amount of future dividends, which will
necessarily be dependent on future earnings, financial requirements of Medtronic
and its subsidiaries, and other factors.
 
    In the Merger, shares of AVE common stock will be converted into shares of
Medtronic common stock based on the Conversion Ratio, which equals $54 divided
by the Average Stock Price for the 15 consecutive NYSE trading days ending on
the second NYSE trading day immediately preceding the Special Meeting, but
subject to a minimum Conversion Ratio of 0.72193 and a maximum Conversion Ratio
of 0.88235. On November 27, 1998, the last trading day preceding public
announcement of the Merger, the reported closing sale price of Medtronic common
stock on the NYSE was $70.00 per share, resulting in an implied Conversion Ratio
(if it were determined based on the closing sale price that day) of 0.77143. On
that day, the reported closing sale price of AVE common stock on the Nasdaq
National Market was
 
                                       35
<PAGE>
$32.375 per share. On [December 15], 1998, the latest practicable trading day
prior to the printing of this Proxy Statement/Prospectus, the closing sale price
of Medtronic common stock on the NYSE was $[68.125] per share, resulting in an
implied Conversion Ratio (if it were determined based on the closing sale price
that day) of [0.79266]. The reported closing sale price of AVE common stock on
the Nasdaq National Market on that day was $[49.00] per share. SHAREHOLDERS ARE
URGED TO OBTAIN CURRENT MARKET QUOTATIONS.
 
    As of December 21, 1998, there were approximately 32,500 registered holders
of Medtronic common stock and approximately 345 registered holders of AVE common
stock.
 
                              RECENT DEVELOPMENTS
 
AVECOR CARDIOVASCULAR INC.
 
    On July 13, 1998, Medtronic announced that it had entered into an agreement
to acquire AVECOR Cardiovascular Inc. ("Avecor"), a company that develops,
manufactures, and markets specialty medical devices for heart/lung bypass
surgery and long-term respiratory support. Pursuant to the acquisition
agreement, upon the fulfillment or waiver of certain conditions, a wholly-owned
subsidiary of Medtronic created for the Avecor acquisition will merge with and
into Avecor. Avecor will then become a wholly-owned subsidiary of Medtronic in a
stock-for-stock merger that is expected to be tax-free and accounted for using
the purchase accounting method. Under the original agreement, each outstanding
share of stock of Avecor would be exchanged for the right to receive the portion
of a share of Medtronic common stock equal to $11.125 divided by the average of
the daily closing sale prices of a share of Medtronic common stock as reported
on the NYSE Composite Tape for the 18 consecutive NYSE trading days ending on
the second NYSE trading day immediately preceding the effective time of the
Avecor merger. The shareholders of Avecor voted and approved the acquisition on
October 28, 1998.
 
    On November 24, 1998, Avecor announced that it had received an unsolicited
offer from a third party to purchase all of Avecor's outstanding common stock at
a price of $13 per share. On December 6, 1998, Medtronic and Avecor announced an
amendment to their acquisition agreement, which calls for $13 in Medtronic
common stock to be issued in the transaction for each Avecor share, or a total
of approximately $106 million. Avecor agreed not to explore alternative
acquisition proposals and ceased discussions with the third party. The amended
agreement also requires Medtronic to pay up to $10 million to Avecor if the
merger is not completed by March 15, 1999, due to failure to obtain FTC
clearance by that date. Medtronic intends to complete the acquisition following
receipt of FTC clearance.
 
SOFAMOR DANEK GROUP, INC.
 
    On November 2, 1998, Medtronic announced that it had entered into an
agreement to acquire Sofamor Danek Group, Inc. ("Sofamor Danek"), a company that
designs and manufactures devices, instruments, computer-assisted visualization
products, and biomaterials used in the treatment of spinal and cranial
disorders. Pursuant to the acquisition agreement, upon the fulfillment or waiver
of certain conditions, a wholly-owned subsidiary of Medtronic created for the
Sofamor Danek acquisition will merge with and into Sofamor Danek. Sofamor Danek
will then become a wholly-owned subsidiary of Medtronic in a stock-for-stock
merger that is expected to be tax-free and accounted for using the
pooling-of-interests method. In the Sofamor Danek merger, which is valued at
approximately $3.6 billion, each outstanding share of stock of Sofamor Danek
will be exchanged for the right to receive shares of Medtronic common stock
equal to $115.00 divided by the average of the daily closing sale prices of a
share of Medtronic common stock as reported on the NYSE Composite Tape for the
15 NYSE trading days ending on the second NYSE trading day preceding the Sofamor
Danek shareholders' meeting for the merger. The price is subject to certain
collar provisions. It is expected that the Sofamor Danek acquisition will be
completed in the first calendar quarter of 1999, but there can be no assurance
that the acquisition will be completed successfully.
 
                                       36
<PAGE>
OTHER INVESTMENTS AND ACQUISITIONS
 
    Medtronic has historically been, and continues to be, actively engaged in
exploring business opportunities through investments and acquisitions. As such,
at any particular time, in addition to investments and acquisitions for which
definitive agreements have been executed and publicly announced, Medtronic is
routinely reviewing several other investment and acquisition opportunities of
varying magnitude and significance or negotiating the terms of such potential
investments and acquisitions prior to the execution of definitive agreements and
public announcements thereof.
 
          UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL STATEMENTS
 
    The following unaudited pro forma financial statements give effect to the
mergers of Medtronic with each of AVE and Sofamor Danek Group, Inc. (Sofamor
Danek), each of which will be accounted for as a pooling of interests. The
unaudited pro forma condensed combined balance sheets give effect to these
transactions as if they had occurred on October 30, 1998. The unaudited pro
forma condensed combined statements of operations give effect to these
transactions as if they had occurred as of May 1, 1995, the beginning of the
earliest period presented.
 
    The operating results for AVE have been converted as described below from
its fiscal year end (June 30) to Medtronic's fiscal year end (April 30). The
operating results for Sofamor Danek have been converted as described below from
its fiscal year end (December 31) to Medtronic's fiscal year end (April 30).
 
    For pro forma purposes, (i) Medtronic's unaudited consolidated balance sheet
as of October 30, 1998 has been combined with AVE's and Sofamor Danek's
unaudited consolidated balance sheets as of September 30, 1998, and (ii)
Medtronic's unaudited consolidated statements of operations for the six months
ended October 30, 1998 and October 31, 1997 and audited statements of operations
for the fiscal years ended April 30, 1998, 1997 and 1996 have been combined with
AVE's and Sofamor Danek's unaudited consolidated statements of operations for
the six months ended September 30, 1998 and 1997 and 12 months ended March 31,
1998, 1997 and 1996, respectively, on a pooling of interests basis.
 
    These pro forma financial statements are presented for illustrative purposes
only and therefore are not necessarily indicative of the operating results or
financial position that might have been achieved had the transactions occurred
as of an earlier date, nor are they necessarily indicative of operating results
or financial position that may occur in the future. These pro forma financial
statements should be read in conjunction with the historical consolidated
financial statements and notes thereto of Medtronic and AVE incorporated by
reference herein. AVE's recent purchases of the Bard Cath Lab business and World
Medical Manufacturing Corporation have not been included in the unaudited pro
forma condensed combined financial statements because they do not constitute
significant business combinations and disclosure is not deemed to be material.
Information on the impact of these transactions is included in AVE's Current
Report on Form 8-K/A that was filed with the SEC on December 14, 1998.
Additional information on Sofamor Danek may be obtained through review of
Sofamor Danek's public filings with the SEC.
 
    As indicated in the footnotes to these pro forma financial statements,
certain pro forma adjustments have been made assuming, solely for the
illustrative purposes of these pro forma financial statements, a conversion
ratio of 0.79266 for the AVE merger and a conversion ratio of 1.68807 for the
Sofamor Danek merger (in each case, based on the closing price of Medtronic
common stock on December 15, 1998).
 
                                       37
<PAGE>
             UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEETS
 
                             AS OF OCTOBER 30, 1998
 
                                 (IN THOUSANDS)
<TABLE>
<CAPTION>
                                                                                                                 PRO FORMA
                                                                        PRO FORMA                              MEDTRONIC AND
                                                         PRO FORMA    MEDTRONIC AND    SOFAMOR     PRO FORMA   SOFAMOR DANEK
                                MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED      DANEK     ADJUSTMENTS    COMBINED
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
<S>                            <C>          <C>        <C>            <C>            <C>          <C>          <C>
ASSETS
Current assets:
  Cash and cash
    equivalents..............   $ 572,341   $ 135,555                  $   707,896    $  70,132                 $   642,473
  Short-term investments.....     244,044      96,729                      340,773        9,535                     253,579
  Accounts receivable, net...     706,531      90,456                      796,987      108,027                     814,558
  Inventories:
    Finished goods...........     205,722       5,486                      211,208       41,417                     247,139
    Work in process..........      88,273       2,786                       91,059        4,771                      93,044
    Raw materials............     130,596       3,272                      133,868        2,704                     133,300
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
      Total inventories......     424,591      11,544                      436,135       48,892                     473,483
Prepaid expenses and other
  current assets.............     324,031      23,729                      347,760       67,967                     391,998
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total current assets.....   2,271,538     358,013                    2,629,551      304,553                   2,576,091
 
Property, plant, and
  equipment, net.............     565,107      78,573                      643,680       56,449                     621,556
Goodwill and other intangible
  assets, net................     673,357      --                          673,357      103,803                     777,160
Long-term investments........     210,801      --                          210,801        1,397                     212,198
Other assets.................     113,772       1,341                      115,113       66,014                     179,786
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total assets.............   $3,834,575  $ 437,927       --         $ 4,272,502    $ 532,216       --        $ 4,366,791
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
 
LIABILITIES AND SHAREHOLDERS'
  EQUITY
Current liabilities:
  Short-term borrowings......   $ 201,320      --                      $   201,320    $  18,085                 $   219,405
  Accounts payable...........      96,179   $  11,718                      107,897        8,909                     105,088
  Accrued liabilities........     476,594      87,227                      563,821       85,605                     562,199
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total current
      liabilities............     774,093      98,945                      873,038      112,599                     886,692
Long-term debt...............      19,534      --                           19,534       18,067                      37,601
Deferred tax liabilities.....         509      --                              509       --                             509
Other long-term
  liabilities................     130,293      --                          130,293       20,317                     150,610
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total liabilities........     924,429      98,945                    1,023,374      150,983                   1,075,412
Shareholders' equity:
  Common stock...............      48,934          64    $   5,040(a)  $    54,038      182,977    $(178,434)(b)       53,477
  Retained earnings..........   2,963,360     339,909    $  (5,040)(a)    3,298,229     199,682    $ 178,434(b)    3,341,476
  Accumulated other non-owner
    changes in equity........     (75,998)       (991)                     (76,989)      (1,426)                    (77,424)
  Receivable from Employee
    Stock Ownership Plan.....     (26,150)     --                          (26,150)      --                         (26,150)
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total shareholders'
      equity.................   2,910,146     338,982       --           3,249,128      381,233       --          3,291,379
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
    Total liabilities and
      shareholders' equity...   $3,834,575  $ 437,927       --         $ 4,272,502    $ 532,216       --        $ 4,366,791
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
                               -----------  ---------  -------------  -------------  -----------  -----------  -------------
 
<CAPTION>
                                PRO FORMA
                               MEDTRONIC,
                                 AVE AND
                                 SOFAMOR
                                  DANEK
                                COMBINED
                               -----------
<S>                            <C>
ASSETS
Current assets:
  Cash and cash
    equivalents..............   $ 778,028
  Short-term investments.....     350,308
  Accounts receivable, net...     905,014
  Inventories:
    Finished goods...........     252,625
    Work in process..........      95,830
    Raw materials............     136,572
                               -----------
      Total inventories......     485,027
Prepaid expenses and other
  current assets.............     415,727
                               -----------
    Total current assets.....   2,934,104
Property, plant, and
  equipment, net.............     700,129
Goodwill and other intangible
  assets, net................     777,160
Long-term investments........     212,198
Other assets.................     181,127
                               -----------
    Total assets.............   $4,804,718
                               -----------
                               -----------
LIABILITIES AND SHAREHOLDERS'
  EQUITY
Current liabilities:
  Short-term borrowings......   $ 219,405
  Accounts payable...........     116,806
  Accrued liabilities........     649,426
                               -----------
    Total current
      liabilities............     985,637
Long-term debt...............      37,601
Deferred tax liabilities.....         509
Other long-term
  liabilities................     150,610
                               -----------
    Total liabilities........   1,174,357
Shareholders' equity:
  Common stock...............      58,581
  Retained earnings..........   3,676,345
  Accumulated other non-owner
    changes in equity........     (78,415)
  Receivable from Employee
    Stock Ownership Plan.....     (26,150)
                               -----------
    Total shareholders'
      equity.................   3,630,361
                               -----------
    Total liabilities and
      shareholders' equity...   $4,804,718
                               -----------
                               -----------
</TABLE>
 
- ------------------------------
 
(a) Reflects 64,386,000 AVE $.001 par common shares outstanding at September 30,
    1998 exchanged for 51,036,207 Medtronic $.10 par common shares assuming a
    0.79266 conversion ratio.
 
(b) Reflects 26,914,000 Sofamor Danek no par common shares outstanding at
    September 30, 1998 exchanged for 45,432,716 Medtronic $.10 par common shares
    assuming a 1.68807 conversion ratio.
 
                                       38
<PAGE>
         UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
 
                   FOR THE SIX MONTHS ENDED OCTOBER 30, 1998
 
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
<TABLE>
<CAPTION>
                                                                                                                 PRO FORMA
                                                                        PRO FORMA                              MEDTRONIC AND
                                                         PRO FORMA    MEDTRONIC AND   SOFAMOR     PRO FORMA    SOFAMOR DANEK
                                MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED     DANEK     ADJUSTMENTS     COMBINED
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
<S>                            <C>          <C>        <C>            <C>            <C>        <C>            <C>
Net sales....................   $1,434,060  $ 343,145                  $ 1,777,205   $ 195,230                  $ 1,629,290
Costs and expenses:
  Cost of products sold......     402,085      56,573                      458,658      35,883                      437,968
  Research and development
    expense..................     160,048      27,535                      187,583      14,850                      174,898
  Selling, general, and
    administrative expense...     413,196      78,281                      491,477      89,157                      502,353
  Non-recurring charges......      21,101      --                           21,101       8,000                       29,101
  Interest expense...........       5,222      --                            5,222       1,345                        6,567
  Interest income............     (17,163)     (5,274)                     (22,437)     --                          (17,163)
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
    Total costs and
      expenses...............     984,489     157,115                    1,141,604     149,235                    1,133,724
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
Earnings before income
  taxes......................     449,571     186,030                      635,601      45,995                      495,566
Provision for income taxes...     150,136      73,438                      223,574      14,371                      164,507
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
Net earnings.................   $ 299,435   $ 112,592                  $   412,027   $  31,624                  $   331,059
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
                               -----------  ---------  -------------  -------------  ---------  -------------  -------------
Weighted average shares
  outstanding................     479,553      62,853      (13,032)(c)      529,374     26,669       18,350(d)      524,572
Basic earnings per share.....   $    0.62   $    1.79                  $      0.78   $    1.19                  $      0.63
Earnings per share assuming
  dilution...................   $    0.61   $    1.71                  $      0.76   $    1.08                  $      0.62
Weighted average shares
  outstanding assuming
  dilution...................     486,909      65,964      (13,677)(c)      539,196     29,194       20,087(d)      536,190
 
<CAPTION>
                                PRO FORMA
                               MEDTRONIC,
                                 AVE AND
                                 SOFAMOR
                                  DANEK
                                COMBINED
                               -----------
<S>                            <C>
Net sales....................   $1,972,435
Costs and expenses:
  Cost of products sold......     494,541
  Research and development
    expense..................     202,433
  Selling, general, and
    administrative expense...     580,634
  Non-recurring charges......      29,101
  Interest expense...........       6,567
  Interest income............     (22,437)
                               -----------
    Total costs and
      expenses...............   1,290,839
                               -----------
Earnings before income
  taxes......................     681,596
Provision for income taxes...     237,945
                               -----------
Net earnings.................   $ 443,651
                               -----------
                               -----------
Weighted average shares
  outstanding................     574,393
Basic earnings per share.....   $    0.77
Earnings per share assuming
  dilution...................   $    0.75
Weighted average shares
  outstanding assuming
  dilution...................     588,477
</TABLE>
 
- ------------------------------
 
(c) Represents 62,853,000 weighted average shares outstanding and 65,964,000
    weighted average shares outstanding assuming dilution of AVE common stock
    converted to 49,821,000 weighted average shares outstanding and 52,287,000
    weighted average shares outstanding assuming dilution of Medtronic common
    stock assuming a 0.79266 conversion ratio.
 
(d) Represents 26,669,000 weighted average shares outstanding and 29,194,000
    weighted average shares outstanding assuming dilution of Sofamor Danek
    common stock converted to 45,019,000 weighted average shares outstanding and
    49,281,000 weighted average shares outstanding assuming dilution of
    Medtronic common stock assuming a 1.68807 conversion ratio.
 
                                       39
<PAGE>
         UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
 
                   FOR THE SIX MONTHS ENDED OCTOBER 31, 1997
 
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
<TABLE>
<CAPTION>
                                                                                                                    PRO FORMA
                                                                         PRO FORMA                                MEDTRONIC AND
                                                          PRO FORMA    MEDTRONIC AND    SOFAMOR      PRO FORMA    SOFAMOR DANEK
                                 MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED      DANEK      ADJUSTMENTS     COMBINED
                                -----------  ---------  -------------  -------------  -----------  -------------  -------------
<S>                             <C>          <C>        <C>            <C>            <C>          <C>            <C>
Net sales.....................   $1,377,508  $  48,485                  $ 1,425,993    $ 151,619                   $ 1,529,127
Costs and expenses:
  Cost of products sold.......     364,127      10,466                      374,593       27,291                       391,418
  Research and development
    expense...................     151,820       9,600                      161,420        9,589                       161,409
  Selling, general, and
    administrative expense....     417,777      14,328                      432,105       71,161                       488,938
  Interest expense............       4,661      --                            4,661        3,045                         7,706
  Interest income.............     (10,331)     (1,996)                     (12,327)      --                           (10,331)
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
    Total costs and
      expenses................     928,054      32,398                      960,452      111,086                     1,039,140
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Earnings before income
  taxes.......................     449,454      16,087                      465,541       40,533                       489,987
Provision for income taxes....     155,095       5,631                      160,726       12,476                       167,571
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Net earnings..................   $ 294,359   $  10,456                  $   304,815    $  28,057                   $   322,416
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Weighted average shares
  outstanding.................     476,872      59,366      (12,309)(e)      523,929      24,786        17,055(f)      518,713
Basic earnings per share......   $    0.62   $    0.18                  $      0.58    $    1.13                   $      0.62
Earnings per share assuming
  dilution....................   $    0.61   $    0.16                  $      0.57    $    1.05                   $      0.61
Weighted average shares
  outstanding assuming
  dilution....................     484,847      64,005      (13,271)(e)      535,581      26,696        18,368(f)      529,911
 
<CAPTION>
                                 PRO FORMA
                                MEDTRONIC,
                                  AVE AND
                                  SOFAMOR
                                   DANEK
                                 COMBINED
                                -----------
<S>                             <C>
Net sales.....................   $1,577,612
Costs and expenses:
  Cost of products sold.......     401,884
  Research and development
    expense...................     171,009
  Selling, general, and
    administrative expense....     503,266
  Interest expense............       7,706
  Interest income.............     (12,327)
                                -----------
    Total costs and
      expenses................   1,071,538
                                -----------
Earnings before income
  taxes.......................     506,074
Provision for income taxes....     173,202
                                -----------
Net earnings..................   $ 332,872
                                -----------
                                -----------
Weighted average shares
  outstanding.................     565,770
Basic earnings per share......   $    0.59
Earnings per share assuming
  dilution....................   $    0.57
Weighted average shares
  outstanding assuming
  dilution....................     580,645
</TABLE>
 
- ------------------------------
 
(e) Represents 59,366,000 weighted average shares outstanding and 64,005,000
    weighted average shares outstanding assuming dilution of AVE common stock
    converted to 47,057,000 weighted average shares outstanding and 50,734,000
    weighted average shares outstanding assuming dilution of Medtronic common
    stock assuming a 0.79266 conversion ratio.
 
(f) Represents 24,786,000 weighted average shares outstanding and 26,696,000
    weighted average shares outstanding assuming dilution of Sofamor Danek
    common stock converted to 41,841,000 weighted average shares outstanding and
    45,064,000 weighted average shares outstanding assuming dilution of
    Medtronic common stock assuming a 1.68807 conversion ratio.
 
                                       40
<PAGE>
         UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
 
                    FOR THE FISCAL YEAR ENDED APRIL 30, 1998
 
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
<TABLE>
<CAPTION>
                                                                                                                   PRO FORMA
                                                                        PRO FORMA                                MEDTRONIC AND
                                                         PRO FORMA    MEDTRONIC AND    SOFAMOR      PRO FORMA    SOFAMOR DANEK
                                MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED      DANEK      ADJUSTMENTS     COMBINED
                               -----------  ---------  -------------  -------------  -----------  -------------  -------------
<S>                            <C>          <C>        <C>            <C>            <C>          <C>            <C>
Net sales....................   $2,783,371  $ 227,991                  $ 3,011,362    $ 331,596                   $ 3,114,967
Costs and expenses:
  Cost of products sold......     760,016      45,668                      805,684       61,446                       821,462
  Research and development
    expense..................     317,957      28,732                      346,689       21,251                       339,208
  Selling, general, and
    administrative expense...     809,546      61,881                      871,427      155,939                       965,485
  Non-recurring charges......     192,400      --                          192,400       --                           192,400
  Interest expense...........       9,756      --                            9,756        5,498                        15,254
  Interest income............     (22,927)     (4,438)                     (27,365)      --                           (22,927)
                               -----------  ---------  -------------  -------------  -----------       ------    -------------
    Total costs and
      expenses...............   2,066,748     131,843                    2,198,591      244,134                     2,310,882
                               -----------  ---------  -------------  -------------  -----------       ------    -------------
Earnings before income
  taxes......................     716,623      96,148                      812,771       87,462                       804,085
Provision for income taxes...     249,746      35,696                      285,442       26,957                       276,703
                               -----------  ---------  -------------  -------------  -----------       ------    -------------
Net earnings.................   $ 466,877   $  60,452                  $   527,329    $  60,505                   $   527,382
                               -----------  ---------  -------------  -------------  -----------       ------    -------------
                               -----------  ---------  -------------  -------------  -----------       ------    -------------
Weighted average shares
  outstanding................     477,243      61,136      (12,496)(g)      525,883      25,039        17,228(h)      519,510
Basic earnings per share.....   $    0.98   $    0.99                  $      1.00    $    2.42                   $      1.02
Earnings per share assuming
  dilution...................   $    0.96   $    0.93                  $      0.98    $    2.22                   $      0.99
Weighted average shares
  outstanding assuming
  dilution...................     484,126      64,675      (13,410)(g)      535,391      27,197        18,713(h)      530,036
 
<CAPTION>
                                PRO FORMA
                               MEDTRONIC,
                                 AVE AND
                                 SOFAMOR
                                  DANEK
                                COMBINED
                               -----------
<S>                            <C>
Net sales....................   $3,342,958
Costs and expenses:
  Cost of products sold......     867,130
  Research and development
    expense..................     367,940
  Selling, general, and
    administrative expense...   1,027,366
  Non-recurring charges......     192,400
  Interest expense...........      15,254
  Interest income............     (27,365)
                               -----------
    Total costs and
      expenses...............   2,442,725
                               -----------
Earnings before income
  taxes......................     900,233
Provision for income taxes...     312,399
                               -----------
Net earnings.................   $ 587,834
                               -----------
                               -----------
Weighted average shares
  outstanding................     568,150
Basic earnings per share.....   $    1.03
Earnings per share assuming
  dilution...................   $    1.01
Weighted average shares
  outstanding assuming
  dilution...................     581,301
</TABLE>
 
- ------------------------------
 
(g) Represents 61,136,000 weighted average shares outstanding and 64,675,000
    weighted average shares outstanding assuming dilution of AVE common stock
    converted to 48,460,000 weighted average shares outstanding and 51,265,000
    weighted average shares outstanding assuming dilution of Medtronic common
    stock assuming a 0.79266 conversion ratio.
 
(h) Represents 25,039,000 weighted average shares outstanding and 27,197,000
    weighted average shares outstanding assuming dilution of Sofamor Danek
    common stock converted to 42,267,000 weighted average shares outstanding and
    45,910,000 weighted average shares outstanding assuming dilution of
    Medtronic common stock assuming a 1.68807 conversion ratio.
 
                                       41
<PAGE>
         UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
 
                    FOR THE FISCAL YEAR ENDED APRIL 30, 1997
 
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
<TABLE>
<CAPTION>
                                                                                                                    PRO FORMA
                                                                         PRO FORMA                                MEDTRONIC AND
                                                          PRO FORMA    MEDTRONIC AND    SOFAMOR      PRO FORMA    SOFAMOR DANEK
                                 MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED      DANEK      ADJUSTMENTS     COMBINED
                                -----------  ---------  -------------  -------------  -----------  -------------  -------------
<S>                             <C>          <C>        <C>            <C>            <C>          <C>            <C>
Net sales.....................   $2,609,361  $  75,123                  $ 2,684,484    $ 260,066                   $ 2,869,427
Costs and expenses:
  Cost of products sold.......     692,964      13,991                      706,955       46,759                       739,723
  Research and development
    expense...................     299,662       8,792                      308,454       17,018                       316,680
  Selling, general, and
    administrative expense....     807,852      18,593                      826,445      125,109                       932,961
  Non-recurring charges.......      --          --                          --            50,000                        50,000
  Interest expense............      11,254      --                           11,254        4,143                        15,397
  Interest income.............     (34,047)     (4,255)                     (38,302)      --                           (34,047)
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
    Total costs and
      expenses................   1,777,685      37,121                    1,814,806      243,029                     2,020,714
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Earnings before income
  taxes.......................     831,676      38,002                      869,678       17,037                       848,713
Provision for income taxes....     287,092      13,286                      300,378        3,181                       290,273
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Net earnings..................   $ 544,584   $  24,716                  $   569,300    $  13,856                   $   558,440
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Weighted average shares
  outstanding.................     485,506      57,647      (11,952)(i)      531,201      24,384        16,777(j)      526,667
Basic earnings per share......   $    1.12   $    0.43                  $      1.07    $    0.57                   $      1.06
Earnings per share assuming
  dilution....................   $    1.10   $    0.39                  $      1.05    $    0.53                   $      1.04
Weighted average shares
  outstanding assuming
  dilution....................     494,019      62,905      (13,043)(i)      543,881      26,137        17,965(j)      538,141
 
<CAPTION>
                                 PRO FORMA
                                MEDTRONIC,
                                  AVE AND
                                  SOFAMOR
                                   DANEK
                                 COMBINED
                                -----------
<S>                             <C>
Net sales.....................   $2,944,550
Costs and expenses:
  Cost of products sold.......     753,714
  Research and development
    expense...................     325,472
  Selling, general, and
    administrative expense....     951,554
  Non-recurring charges.......      50,000
  Interest expense............      15,397
  Interest income.............     (38,302)
                                -----------
    Total costs and
      expenses................   2,057,835
                                -----------
Earnings before income
  taxes.......................     886,715
Provision for income taxes....     303,559
                                -----------
Net earnings..................   $ 583,156
                                -----------
                                -----------
Weighted average shares
  outstanding.................     572,362
Basic earnings per share......   $    1.02
Earnings per share assuming
  dilution....................   $    0.99
Weighted average shares
  outstanding assuming
  dilution....................     588,003
</TABLE>
 
- ------------------------------
 
(i) Represents 57,647,000 weighted average shares outstanding and 62,905,000
    weighted average shares outstanding assuming dilution of AVE common stock
    converted to 45,695,000 weighted average shares outstanding and 49,862,000
    weighted average shares outstanding assuming dilution of Medtronic common
    stock assuming a 0.79266 conversion ratio.
 
(j) Represents 24,384,000 weighted average shares outstanding and 26,137,000
    weighted average shares outstanding assuming dilution of Sofamor Danek
    common stock converted to 41,161,000 weighted average shares outstanding and
    44,122,000 weighted average shares outstanding assuming dilution of
    Medtronic common stock assuming a 1.68807 conversion ratio.
 
                                       42
<PAGE>
         UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
 
                    FOR THE FISCAL YEAR ENDED APRIL 30, 1996
 
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
<TABLE>
<CAPTION>
                                                                                                                    PRO FORMA
                                                                         PRO FORMA                                MEDTRONIC AND
                                                          PRO FORMA    MEDTRONIC AND    SOFAMOR      PRO FORMA    SOFAMOR DANEK
                                 MEDTRONIC      AVE      ADJUSTMENTS   AVE COMBINED      DANEK      ADJUSTMENTS     COMBINED
                                -----------  ---------  -------------  -------------  -----------  -------------  -------------
<S>                             <C>          <C>        <C>            <C>            <C>          <C>            <C>
Net sales.....................   $2,326,836  $  44,128                  $ 2,370,964    $ 199,077                   $ 2,525,913
Costs and expenses:
  Cost of products sold.......     664,531       9,726                      674,257       40,906                       705,437
  Research and development
    expense...................     263,933       5,379                      269,312       14,264                       278,197
  Selling, general, and
    administrative expense....     747,245       6,545                      753,790       93,166                       840,411
  Interest expense............      10,531      --                           10,531        3,400                        13,931
  Interest income.............     (31,124)       (502)                     (31,626)      --                           (31,124)
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
    Total costs and
      expenses................   1,655,116      21,148                    1,676,264      151,736                     1,806,852
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Earnings before income
  taxes.......................     671,720      22,980                      694,700       47,341                       719,061
Provision for income taxes....     235,582       7,762                      243,344       10,677                       246,259
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Net earnings..................   $ 436,138   $  15,218                  $   451,356    $  36,664                   $   472,802
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
                                -----------  ---------  -------------  -------------  -----------       ------    -------------
Weighted average shares
  outstanding.................     482,923      42,184       (8,747)(k)      516,360      23,934        16,468(l)      523,325
Basic earnings per share......   $    0.90   $    0.36                  $      0.87    $    1.53                   $      0.90
Earnings per share assuming
  dilution....................   $    0.89   $    0.28                  $      0.84    $    1.44                   $      0.88
Weighted average shares
  outstanding assuming
  dilution....................     492,209      54,773      (11,356)(k)      535,626      25,533        17,568(l)      535,310
 
<CAPTION>
                                 PRO FORMA
                                MEDTRONIC,
                                  AVE AND
                                  SOFAMOR
                                   DANEK
                                 COMBINED
                                -----------
<S>                             <C>
Net sales.....................   $2,570,041
Costs and expenses:
  Cost of products sold.......     715,163
  Research and development
    expense...................     283,576
  Selling, general, and
    administrative expense....     846,956
  Interest expense............      13,931
  Interest income.............     (31,626)
                                -----------
    Total costs and
      expenses................   1,828,000
                                -----------
                                -----------
Earnings before income
  taxes.......................     742,041
Provision for income taxes....     254,021
                                -----------
Net earnings..................   $ 488,020
                                -----------
                                -----------
Weighted average shares
  outstanding.................     556,762
Basic earnings per share......   $    0.88
Earnings per share assuming
  dilution....................   $    0.84
Weighted average shares
  outstanding assuming
  dilution....................     578,727
</TABLE>
 
- ------------------------------
 
(k) Represents 42,184,000 weighted average shares outstanding and 54,773,000
    weighted average shares outstanding assuming dilution of AVE common stock
    converted to 33,437,000 weighted average shares outstanding and 43,417,000
    weighted average shares outstanding assuming dilution of Medtronic common
    stock assuming a 0.79266 conversion ratio.
 
(l) Represents 23,934,000 weighted average shares outstanding and 25,533,000
    weighted average shares outstanding assuming dilution of Sofamor Danek
    common stock converted to 40,402,000 weighted average shares outstanding and
    43,101,000 weighted average shares outstanding assuming dilution of
    Medtronic common stock assuming a 1.68807 conversion ratio.
 
                                       43
<PAGE>
      NOTES TO UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL STATEMENTS
 
NOTE 1
 
    The unaudited pro forma financial statements give effect to the mergers of
Medtronic with each of Arterial Vascular Engineering, Inc. (AVE) and Sofamor
Danek Group, Inc. (Sofamor Danek) using the pooling of interests method of
accounting. The unaudited pro forma condensed combined balance sheets give
effect to these transactions as if they had occurred on October 30, 1998. The
unaudited pro forma condensed combined statements of operations give effect to
these transactions as if they had occurred as of May 1, 1995, the beginning of
the earliest period presented.
 
    The pro forma financial statements are presented for illustrative purposes
only and therefore are not necessarily indicative of the operating results or
financial position that might have been achieved had the transactions occurred
as of an earlier date, nor are they necessarily indicative of operating results
or financial position that may occur in the future.
 
    These pro forma financial statements should be read in conjunction with the
historical consolidated financial statements and notes thereto of Medtronic and
AVE incorporated by reference herein. Additional information on Sofamor Danek
may be obtained through review of Sofamor Danek's public filings with the
Securities and Exchange Commission.
 
NOTE 2
 
    The unaudited pro forma condensed combined balance sheets reflect
Medtronic's unaudited consolidated balance sheet as of October 30, 1998 combined
with AVE's and Sofamor Danek's unaudited consolidated balance sheets as of
September 30, 1998.
 
NOTE 3
 
    The unaudited pro forma condensed combined statements of operations reflect
Medtronic's unaudited consolidated statements of operations for the six months
ended October 30, 1998 and October 31, 1997 and audited statements of operations
for the fiscal years ended years ended April 30, 1998, 1997 and 1996 combined
with AVE's and Sofamor Danek's unaudited consolidated statements of operations
for the six months ended September 30, 1998 and 1997 and 12 months ended March
31, 1998, 1997 and 1996, respectively, on a pooling of interests basis.
 
NOTE 4
 
    The unaudited pro forma condensed combined financial statements do not give
effect to AVE's acquisition of the Bard Cath Lab Business which was consummated
on October 1, 1998. The Bard Cath Lab acquisition has not been included in the
unaudited pro forma condensed combined financial statements because it does not
constitute a significant business combination and disclosure is not deemed to be
material. The Bard Cath Lab business includes a broad range of catheter-based
technologies including PTCA balloon catheters, guidewires, guide catheters,
coronary diagnostic catheters and guidewires, introducers and vessel closure
devices, coronary stents, and various other components and accessories. AVE's
acquisition of Bard Cath Lab was accounted for as a purchase business
combination. The purchase price of $550 million was allocated to tangible net
assets of $54 million, in process research and development of $98 million,
intangible assets of $73 million and goodwill of $325 million. The in-process
research and development charge of $98 million was recorded by AVE in October
1998.
 
    On December 14, 1998, AVE acquired World Medical Manufacturing Corporation
(World Medical), a manufacturer of medical devices for the treatment of
abdominal aortic aneurysms, for $62 million. The World Medical acquisition has
not been included in the unaudited pro forma condensed combined financial
statements because it does not constitute a significant business combination and
disclosure is not deemed to be material. In connection with the purchase
business combination, AVE expects to record an in-process research and
development charge of approximately $42 million.
 
    In addition to professional fees and change-in-control payments in
connection with the AVE transaction, Medtronic expects that there will be
additional costs incurred related to closing duplicate facilities and
eliminating duplicate administrative functions. The total costs incurred may
exceed $100 million.
 
NOTE 5
 
    The accounting policies of the separate companies are currently being
studied from a conformity perspective. The impact of conforming accounting
principles, if any, is not expected to be material.
 
                                       44
<PAGE>
             COMPARISON OF RIGHTS OF MEDTRONIC AND AVE SHAREHOLDERS
 
    Medtronic and AVE are incorporated under the laws of Minnesota and Delaware,
respectively. Upon consummation of the Merger, shareholders of AVE will become
shareholders of Medtronic, and their rights will be governed by the laws of
Minnesota, not Delaware. The rights of Medtronic shareholders under Medtronic's
Restated Articles of Incorporation as amended ("Medtronic's Articles") and
Medtronic's Bylaws differ in certain respects from the rights of AVE
shareholders under AVE's Certificate of Incorporation ("AVE's Certificate") and
AVE's Bylaws. Certain significant differences between the rights of Medtronic
shareholders and AVE shareholders are summarized below. This summary does not,
however, purport to be a complete description of all of the differences between
the rights of shareholders of AVE and the rights of shareholders of Medtronic.
 
CLASSIFICATION, REMOVAL, AND NOMINATION OF DIRECTORS
 
    CLASSIFICATION.  Medtronic's Articles provide for a classified Board of
Directors, under which directors are elected to three-year terms, with one-third
of the directors being elected each year. AVE's Certificate and Bylaws do not
similarly classify its Board of Directors, and directors are elected each year
for a one-year term. Both Medtronic's Articles and AVE's Bylaws provide for
vacancies on the Board to be filled by a vote of the majority of the remaining
Board members.
 
    REMOVAL.  Medtronic's Articles provide that directors may be removed, with
or without cause, only by the vote of not less than 75% of the voting power of
all then outstanding voting shares. AVE's Bylaws provide that directors may be
removed, with or without cause, at any meeting of the Board by the affirmative
vote of a majority of the other directors. In addition, any AVE director may be
removed, with or without cause, by the holders of a majority of shares entitled
to vote for the election of directors.
 
    NOMINATION.  Medtronic's Articles provide that nominations for the election
of directors may be made by or at the direction of the Medtronic Board of
Directors or by any shareholder entitled to vote in the election of directors
generally. Nominations by shareholders must be made pursuant to timely notice in
writing to the Secretary of Medtronic. To be timely, a shareholder's notice must
be delivered to or mailed and received at the principal executive offices of
Medtronic not less than 50 days nor more than 90 days prior to the meeting;
provided, however, that if less than 60 days' notice or prior public disclosure
of the date of the meeting is given or made to the shareholders, notice by the
shareholder to be timely must be so received not later than the close of
business on the tenth day following the day on which such notice of the date of
the meeting was mailed or such public disclosure was made. The notice must set
forth certain information concerning such shareholder and his or her nominee(s),
including their names and addresses, the principal occupation or employment of
the nominee(s), the class and number of shares of capital stock of Medtronic
that are beneficially owned by such persons, such other information as would be
required to be included in a proxy statement soliciting proxies for the election
of the nominees of such shareholder, and the consent of each nominee to serve as
a director of Medtronic if so elected.
 
    AVE's Bylaws provide that nominations for the election of directors may be
made by the AVE Board or by any shareholder entitled to vote in the election of
directors, provided, however, that a shareholder may nominate a person for
election as a director at a meeting only if written notice of such shareholder's
intent has been given to the Secretary of AVE not later than 60 nor more than 90
days in advance of the anniversary of the previous year's annual meeting. The
notice must contain the name and address of the shareholder and of the person or
persons to be nominated, a representation that the shareholder is a holder of
record of AVE stock entitled to vote at the meeting and intends to appear in
person or by proxy at the meeting and nominate the person or persons specified
in the notice, a description of all arrangements, understandings or
relationships between the shareholder and each nominee and any other person
(naming such person), such other information as would be required to be included
to be in a proxy statement filed pursuant to the proxy rules of the SEC had the
nominee been nominated, or intended to be
 
                                       45
<PAGE>
nominated, by the AVE Board, and the consent of each nominee to serve as a
director of AVE if so elected.
 
    AMENDMENT OF PROVISIONS.  Medtronic's Articles require the affirmative vote
of not less than 75% of the voting power of all then outstanding voting shares
to amend, repeal or adopt any provisions inconsistent with these provisions
regarding classification, removal and nomination of directors. AVE's Bylaws
require the affirmative vote of a majority of the directors to modify such
provisions or the affirmative vote of at least 80 percent of the voting power of
all of the then outstanding shares of AVE common stock.
 
    The above-described provisions of Medtronic's Articles regarding directors
will be subject to the terms of the certificate of designation or other
instrument creating any class or series of preferred stock giving the holders of
such class or series of preferred stock the right, voting separately as a class,
to elect one or more directors (such as is often required by the terms of
preferred stock in the event that dividend payments are in arrears for a period
of time). See "--Preferred Stock."
 
    These provisions regarding classification, removal, and nomination of
directors afford some assurance of stability in the composition of the Medtronic
Board of Directors, but may discourage or deter attempts by individuals or
entities to take control of Medtronic by electing their own slate of directors.
To the extent that potential acquirers of Medtronic stock are deterred by the
classified Board, such provision also may deter certain mergers, tender offers,
or other future takeover attempts which some or a majority of holders of
Medtronic common stock may deem to be in their best interests. In addition, the
classified Medtronic Board would delay shareholders who do not favor the
policies of Medtronic's Board of Directors from removing a majority of the
Medtronic Board of Directors for two years, unless they can obtain the requisite
vote.
 
    LIABILITY OF DIRECTORS.  Medtronic's Articles exempt directors from personal
liability to the corporation or its shareholders for monetary damages for breach
of fiduciary duty as a director to the full extent permitted by Minnesota law.
AVE's Certificate contains a similar provision.
 
PREFERRED STOCK
 
    Medtronic has 2,500,000 authorized but unissued shares of preferred stock,
par value $1 per share. Medtronic's Articles provide that whenever the holders
of a class or series of preferred stock have the right to elect any directors,
the election, term and other features of such directorships shall be governed by
the terms set forth in the resolution of the Medtronic Board of Directors
designating the rights and preferences of such class or series of preferred
stock, and any directors elected by the holders of preferred stock shall not be
divided into classes unless provision is expressly made for such classification
by the terms of such preferred stock. Shares of Medtronic preferred stock could
be issued that would have the right to elect directors, either separately or
together with the Medtronic common stock, with such directors either divided or
not divided into classes.
 
    Under certain circumstances such Medtronic preferred stock could be used to
create voting impediments or to deter persons seeking to effect a takeover or
otherwise gain control of Medtronic in a transaction which holders of some or a
majority of the Medtronic common stock may deem to be in their best interests.
Such shares of Medtronic preferred stock could be sold in public or private
transactions to purchasers who might support the Medtronic Board of Directors in
opposing a takeover bid that the Medtronic Board of Directors determines not to
be in the best interests of Medtronic and its shareholders. In addition, the
Medtronic Board of Directors could authorize holders of a class or series of
preferred stock to vote, either separately as a class or together with the
holders of Medtronic common stock, on any merger, sale, or exchange of assets by
Medtronic or any other extraordinary corporate transaction. The ability to issue
such Medtronic preferred stock might have the effect of discouraging an attempt
by another person or entity, through the acquisition of a substantial number of
shares of Medtronic common stock, to acquire control of Medtronic with a view to
imposing a merger, sale of all or any part of the assets or a
 
                                       46
<PAGE>
similar transaction, because the issuance of new shares could be used to dilute
the stock ownership of such person or entity. See "--Shareholder Rights Plans."
 
    AVE has 5,000,000 authorized but unissued shares of preferred stock, par
value $.001 per share, and the Board of Directors has the authority to fix the
terms of such shares without further shareholder voting, consent, or
ratification.
 
SPECIAL MEETINGS OF SHAREHOLDERS
 
    Under Minnesota law, a special meeting of shareholders may be called by
certain officers, two or more directors, a person authorized to do so in the
articles or bylaws, or shareholders holding at least 10% of the voting power of
all shares entitled to vote, except that a special meeting for the purpose of
considering an action to effect, directly or indirectly, a business combination
must be called by shareholders holding at least 25% of the voting power of all
shares entitled to vote.
 
    Under Delaware law, special meetings of shareholders of a corporation may be
called by the corporation's Board of Directors or by persons specifically
authorized to do so by the corporation's articles of incorporation or bylaws.
AVE's Bylaws provide that special meetings may be called only by the Chairman of
the Board, the Chief Executive Officer, or the Board of Directors pursuant to a
resolution adopted by a majority of the Board. Shareholders are not permitted to
call special meetings or to require the Board to call a special meeting. Any
request for a special meeting must be submitted in writing to the Chairman of
the Board, the President, or the Secretary of AVE and must state the purpose of
the proposed special meeting.
 
VOTING RIGHTS; SHAREHOLDER APPROVALS
 
    Under both Medtronic's Articles and AVE's Certificate, holders of Medtronic
common stock and AVE common stock, respectively, are entitled to one vote per
share on all matters submitted to a vote of the shareholders. Medtronic's Bylaws
provide that, except as specifically required otherwise under Medtronic's
Articles or Bylaws or Minnesota law, all matters submitted to the shareholders
are decided by a majority vote of the shares entitled to vote and represented at
a meeting at which there is a quorum. AVE's Bylaws provide that at any meeting
of shareholders, all matters, except as otherwise provided in AVE's Certificate
or Bylaws or by Delaware law, are decided by the vote of a majority in voting
interest of the shareholders present in person or by proxy and entitled to vote.
 
CUMULATIVE VOTING
 
    Neither Medtronic's Articles nor AVE's Certificate or Bylaws provide for
cumulative voting with regard to the Medtronic common stock or the AVE common
stock, respectively.
 
PREEMPTIVE RIGHTS
 
    Under Medtronic's Articles, holders of Medtronic stock are expressly denied
preemptive rights. AVE's Certificate does not contain any provision concerning
preemptive rights. Under Delaware law, shareholders of a Delaware corporation do
not have preemptive rights, except to the extent provided in a corporation's
Certificate.
 
AMENDMENT OF THE ARTICLES OR CERTIFICATE OF INCORPORATION
 
    Under Minnesota law and Delaware law, an amendment to the articles or
certificate of incorporation requires the affirmative vote of the holders of a
majority of the shares present and entitled to vote unless a larger affirmative
vote is required by the corporation's articles or certificate. Medtronic's
Articles do not contain any provisions that require a larger affirmative vote in
order to amend Medtronic's Articles. AVE's Bylaws provide that the Bylaws cannot
be altered, amended, or repealed without the affirmative vote of a
 
                                       47
<PAGE>
majority of the Board or the affirmative vote of at least 80 percent of the
voting power of the then outstanding shares of common stock.
 
BUSINESS COMBINATIONS AND CONTROL SHARE ACQUISITIONS
 
    Medtronic is governed by Sections 302A.671 and 302A.673 of the Minnesota
Business Corporation Act. In general, Section 302A.671 provides that the shares
of a corporation acquired in a "control share acquisition" have no voting rights
unless voting rights are approved in a prescribed manner. A "control share
acquisition" is an acquisition, directly or indirectly, of beneficial ownership
of shares that would, when added to all other shares beneficially owned by the
acquiring person, entitle the acquiring person to have voting power of 20% or
more in the election of directors. In general, Section 302A.673 prohibits a
public Minnesota corporation from engaging in a "business combination" with an
"interested shareholder" for a period of four years after the date of the
transaction in which the person became an interested shareholder, unless the
business combination is approved in a prescribed manner. "Business combination"
includes mergers, asset sales and other transactions resulting in a financial
benefit to the interested shareholder. An "interested shareholder" is a person
who is the beneficial owner, directly or indirectly, of 10% or more of the
corporation's voting stock or who is an affiliate or associate of the
corporation and at any time within four years prior to the date in question was
the beneficial owner, directly or indirectly, of 10% or more of the
corporation's voting stock. Such provisions of Minnesota law could have the
effect of delaying, deferring, or preventing a change in control of Medtronic.
 
    Under Delaware law, no business combination (defined to include certain
mergers, sales of assets, sales of five percent or more of outstanding stock,
loans, recapitalizations or liquidations or dissolutions) involving a Delaware
corporation and an interested shareholder (defined to be any holder of 10% or
more of the corporation's voting stock) may be entered into unless (i) either
the share acquisition or business combination was approved by the board of
directors of the corporation before the shareholder became an interested
shareholder or (ii) (a) five years have expired since the acquisition of shares
of the corporation by the interested shareholder, (b) all requirements of the
corporation's articles of incorporation relating to business combinations are
satisfied and (c) either (1) a majority of shareholders of the corporation
(excluding the interested shareholder) approves the business combination or (2)
all shareholders are paid fair value for their stock. However, such law does not
restrict any offer to purchase all of a corporation's shares.
 
SHAREHOLDER RIGHTS PLANS
 
    MEDTRONIC.  Medtronic has in effect a Shareholder Rights Plan and has
entered into a Rights Agreement with Norwest Bank Minnesota, N.A., as Rights
Agent. The Rights Plan provides for a dividend distribution of one preferred
stock purchase right (a "Right") to be attached to each outstanding share of
Medtronic common stock. As a result of the Merger, each share of Medtronic
common stock received in the Merger will also represent one Right. The Right
associated with each outstanding share of Medtronic common stock entitles the
holder to buy 1/1600th of a Series A Junior Participating Preferred Share (the
"Series A Preferred Shares") of Medtronic, which is substantially equivalent to
one share of Medtronic common stock, at an exercise price of $37.50 per 1/1600th
of a Series A Preferred Share. The Rights are not currently exercisable or
transferable apart from the Medtronic common stock.
 
    The Rights will become exercisable if a person or group acquires 15% or more
of the Medtronic common stock (and thereby becomes an "Acquiring Person") or
announces a tender offer or exchange offer that would increase the Acquiring
Person's beneficial ownership to 15% or more of the outstanding Medtronic common
stock, subject to certain exceptions. After the Rights become exercisable, each
Right entitles the holder (other than the Acquiring Person) to purchase
Medtronic common stock that has a market value of two times the exercise price
of the Right. If Medtronic is acquired in a merger or other business combination
transaction, each exercisable Right entitles the holder to purchase common stock
of the Acquiring Person or an affiliate that has a market value of two times the
exercise price of the Right.
 
                                       48
<PAGE>
Each Right is redeemable by Medtronic at $.000625 any time before a person or
group triggers the 15% threshold to become an Acquiring Person. The Rights
expire on July 10, 2001.
 
    The Rights issued under the Medtronic Shareholder Rights Plan may make any
merger not approved by Medtronic's Board of Directors prohibitively expensive,
because the Rights allow Medtronic shareholders to purchase the voting
securities of Medtronic or a potential acquirer at one-half of its fair market
value.
 
    AVE.  AVE has a Rights Agreement, which is intended to deter hostile or
coercive attempts to acquire AVE and which was amended in May 1998 to account
for the recent increase in the market price of AVE common stock (the "AVE Rights
Agreement"). The AVE Rights Agreement enables shareholders to acquire shares of
AVE common stock, or the common stock of an acquiror, at a substantial discount
to the public market price if any person or group acquires more than 15% of AVE
common stock without the approval of the AVE Board under certain circumstances.
AVE has reserved 1,000,000 shares of Series A Junior Participating Preferred
Stock for issuance in connection with the AVE Rights Agreement. While the AVE
Board has no current intentions or plans to issue any preferred stock, issuance
of these shares could also be used as an anti-takeover device. Immediately prior
to execution of the Merger Agreement, the AVE Rights Agreement was amended so
that Medtronic would not become an Acquiring Person and the Merger will not
cause a Distribution Date or Shares Acquisition Date, as such terms are defined
in the Rights Agreement. See "The Merger--Shareholder Rights Plans."
 
RELATED PERSON BUSINESS TRANSACTIONS
 
    Medtronic's Articles provide that, in certain circumstances, an affirmative
vote of two-thirds of the voting power of all then outstanding voting shares is
required for the approval or authorization of any "related person business
transaction." Such two-thirds approval is not required, however, if (1) a
majority vote of "continuing directors" (as defined below) expressly approves
the related person business transaction, or (2) the related person business
transaction is a merger, consolidation, exchange of shares or sale of all or
substantially all of the assets of Medtronic, and the cash or fair market value
of the property received by the Medtronic shareholders is equal to a defined
minimum purchase price. For purposes of this provision, a "continuing director"
means, generally, those directors who were directors before the "related person"
(as defined below) became a related person.
 
    Generally, a related person business transaction includes (1) any merger or
consolidation of Medtronic with or into a related person, (2) any exchange of
shares of Medtronic (or a subsidiary) for shares of a related person which would
have required an affirmative vote of at least a majority of the voting power of
the outstanding shares entitled to vote, (3) any sale, lease, exchange,
transfer, or other disposition (in one transaction or a series of transactions),
including without limitation a mortgage or any other security device, of all or
any substantial part of the assets of Medtronic (or a subsidiary) to or with a
related person, (4) any sale, lease, transfer, or other disposition (in one
transaction or a series of transactions) of all or any substantial part of the
assets of a related person to or with Medtronic (or a subsidiary), (5) the
issuance, sale, transfer, or other disposition to a related person of any
securities of Medtronic (except pursuant to stock dividends, stock splits, or
similar transactions that would not have the effect of increasing the proportion
of voting power of a related person) or of a subsidiary (except pursuant to a
pro rata distribution to all holders of Medtronic common stock), (6) any
recapitalization or reclassification that would have the effect of increasing
the proportionate voting power of a related person, and (7) any agreement,
contract, arrangement, or understanding providing for any of the transactions
described above.
 
    Generally, for purposes of a related person business transaction, the term
"related person" is broadly defined to include a wide range of potential
persons, including any person or entity that, together with affiliates and
associates, beneficially owns 15% or more of the outstanding voting stock of
Medtronic.
 
    Such a provision could have the effect of impeding a potential acquirer of
Medtronic by requiring a larger than normal majority of Medtronic shareholders
to approve a transaction.
 
                                       49
<PAGE>
    There is no similar "related person business transaction" provision in AVE's
Certificate.
 
                     CERTAIN TRANSACTIONS AND RELATIONSHIPS
                           BETWEEN AVE AND MEDTRONIC
 
    STOCK OPTION AGREEMENT.  AVE and Medtronic are parties to a Stock Option
Agreement dated November 29, 1998, pursuant to which AVE has granted to
Medtronic an option, exercisable under certain specified circumstances related
to the termination of the Merger Agreement, to purchase 12,807,795 shares of AVE
common stock, which equaled approximately 19.9% of AVE's shares outstanding on
November 29, 1998. See "The Merger--Stock Option Agreement."
 
    VOTING AGREEMENTS.  All of the executive officers and directors of AVE who
own stock or options to acquire stock of AVE have entered into voting agreements
with Medtronic pursuant to which they have agreed to vote all of the outstanding
shares of AVE common stock beneficially owned by them on the record date in
favor of the Merger. See "The Merger--Voting Agreements."
 
                                 LEGAL MATTERS
 
    The validity of the Medtronic common stock to be issued in connection with
the Merger and certain other legal matters for Medtronic, including the federal
income tax consequences in connection with the Merger, will be passed upon for
Medtronic by Fredrikson & Byron, P.A., Minneapolis, Minnesota. Members of such
firm own, in the aggregate, approximately 86,400 shares of Medtronic common
stock.
 
    Certain legal matters for AVE, including the federal income tax consequences
in connection with the Merger, were passed upon by Cooley Godward LLP, Palo
Alto, California.
 
                                    EXPERTS
 
    The consolidated financial statements of Medtronic as of April 30, 1998 and
1997 and for each of the three years in the period ended April 30, 1998
incorporated in this Proxy Statement/Prospectus by reference to the Current
Report on Form 8-K that was filed with the SEC on November 30, 1998 have been so
incorporated in reliance on the report of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting.
 
    The consolidated financial statements of AVE appearing in AVE's Annual
Report (Form 10-K) for the year ended June 30, 1998 have been audited by Ernst &
Young LLP, independent auditors, as set forth in their report thereon included
therein and incorporated herein by reference. Such consolidated financial
statements are incorporated herein by reference in reliance upon such report
given upon the authority of such firm as experts in accounting and auditing.
 
                      WHERE YOU CAN FIND MORE INFORMATION
 
    Medtronic and AVE file annual, quarterly, and special reports, proxy
statements, and other information with the SEC. You may read and copy any
reports, statements, or other information filed by Medtronic or AVE at the SEC's
public reference rooms at 450 5th Street, N.W., Washington, D.C. 20549, or at 7
World Trade Center, Suite 1300, New York, New York 10048, or at Citicorp Center,
500 W. Madison Street, Suite 1400, Chicago, Illinois 60661. Please call the SEC
at 1-800-SEC-0330 for more information on the public reference rooms. The SEC
also maintains an Internet site at "http://www.sec.gov" that contain reports,
proxy and information statements, and other information regarding issuers, like
Medtronic and AVE, that file electronically with the SEC.
 
    You can also inspect reports, proxy statements, and other information about
Medtronic at the offices of the New York Stock Exchange, 20 Broad Street, New
York, New York 10005. You can inspect
 
                                       50
<PAGE>
information about AVE at the offices of the Nasdaq National Market, 1735 K
Street, N.W., Washington, D.C. 20006
 
    Medtronic has filed with the SEC a Registration Statement on Form S-4 to
register the Medtronic common stock to be issued in the Merger. This Proxy
Statement/Prospectus is a part of that Registration Statement and constitutes a
prospectus of Medtronic in addition to being a proxy statement of AVE for the
Special Meeting. As allowed by SEC rules, this Proxy Statement/Prospectus does
not contain all the information you can find in the Registration Statement and
the exhibits to the Registration Statement.
 
    The SEC allows us to "incorporate by reference" information into this Proxy
Statement/ Prospectus, which means that we can disclose important information to
you by referring you to another document filed separately with the SEC. The
information incorporated by reference is considered part of this Proxy
Statement/Prospectus, except for any information superseded by information in
(or incorporated by reference in) this Proxy Statement/Prospectus.
 
    This Proxy Statement/Prospectus incorporates by reference the documents
listed below that Medtronic and AVE have previously filed with the SEC. These
documents contain important information about Medtronic and AVE and their
finances.
 
<TABLE>
<CAPTION>
MEDTRONIC SEC FILINGS
(FILE NO. 1-07707)                             PERIOD
- ---------------------------------------------  ---------------------------------------------
<S>                                            <C>
Annual Report on Form 10-K, s amended          Year ended April 30, 1998
 
Quarterly Reports on Form 10-Q                 Quarters ended July 31, 1998 and October 30,
                                               1998
 
Current Reports on Form 8-K                    Filed July 8, 1998, July 16, 1998, August 20,
                                               1998, September 17, 1998, September 22, 1998,
                                               September 23, 1998, October 1, 1998, November
                                               9, 1998, November 19, 1998, November 30,
                                               1998, and December 3, 1998
 
Description of Medtronic's common stock
contained in Medtronic's registration
statement on Form 8-A
 
Description of Medtronic's preferred stock
purchase rights attached to its common stock
contained in Medtronic's registration
statement on Form 8-A
</TABLE>
 
                                       51
<PAGE>
 
<TABLE>
<CAPTION>
AVE SEC FILINGS
(FILE NO. 0-27802)                             PERIOD
- ---------------------------------------------  ---------------------------------------------
<S>                                            <C>
Annual Report on Form 10-K, as amended         Year ended June 30, 1998
Quarterly Report on Form 10-Q                  Quarter ended September 30, 1998
Current Report on Form 8-K or 8-K/A            Filed July 23, 1998, October 15, 1998,
                                               November 12, 1998, December 1, 1998, and
                                               December 14, 1998
Description of AVE's common stock contained
in AVE's registration statement on Form 8-A
</TABLE>
 
    Medtronic and AVE are also incorporating by reference all additional
documents that either company may file with the SEC between the date of this
Proxy Statement/Prospectus and the date of the Special Meeting.
 
    If you are a shareholder of Medtronic or AVE, Medtronic and AVE may have
sent you some of the documents incorporated by reference, but you can obtain any
of them from Medtronic, AVE, or the SEC. Documents incorporated by reference are
available from Medtronic or AVE without charge, except for any exhibits to those
documents unless we have specifically incorporated by reference a particular
exhibit in this Proxy Statement/Prospectus. Shareholders may obtain documents
incorporated by reference in this Proxy Statement/Prospectus by requesting them
in writing or by telephone from the appropriate party at the following
addresses:
 
<TABLE>
<S>        <C>                                         <C>
           Medtronic, Inc.                             Arterial Vascular Engineering, Inc.
           7000 Central Avenue, N.E.                   3576 Unocal Place
           Minneapolis, Minnesota 55432                Santa Rosa, California 95403
           Attention: Investor Relations Department    Attention: Investor Relations
           (612) 514-3035                              (707) 541-3135
</TABLE>
 
    IF YOU WOULD LIKE TO REQUEST DOCUMENTS FROM MEDTRONIC OR AVE, PLEASE DO SO
BY [JANUARY 21], 1999 to receive them before the Special Meeting.
 
    You can also direct any questions or requests for assistance in completing
and submitting Proxy cards to AVE's proxy solicitor for the Special Meeting:
 
                       CORPORATE INVESTOR COMMUNICATIONS
                               111 Commerce Road
                              Carlstadt, NJ 07072
                           Telephone: (615) 896-5600
 
    We have not authorized anyone to provide you with information that is
different from, or in addition to, what is contained or referred to in this
Proxy Statement/Prospectus. Medtronic has supplied all information contained or
incorporated by reference in this Proxy Statement/Prospectus relating to
Medtronic, and AVE has supplied all such information relating to AVE. If you are
in a jurisdiction where offers to exchange or sell, or solicitations of offers
to exchange or buy, the securities offered by this document or the solicitation
of proxies is unlawful, or if you are a person to whom it is unlawful to direct
these types of activities, then the offer presented in this document does not
extend to you. The information contained in this document speaks only as of the
date of this document unless the information specifically indicates that another
date applies.
 
                                       52
<PAGE>
                          FORWARD-LOOKING INFORMATION
 
    Certain statements contained in this Proxy Statement/Prospectus (including
information incorporated by reference) and other written and oral statements
made from time to time by Medtronic and AVE do not relate strictly to historical
or current facts. As such, they are considered "forward-looking statements"
which provide current expectations or forecasts of future events. Such
statements can be identified by the use of words such as "anticipate,"
"believe," "could," "estimate," "expect," "forecast," "intend," "may," "plan,"
"possible," "project," "should," "will," and similar words or expressions.
Medtronic's and AVE's respective forward-looking statements generally relate to
their respective growth strategies, financial results, product development and
regulatory approval programs, and sales efforts. You should carefully consider
forward-looking statements and understand that such statements involve a variety
of risks and uncertainties, known and unknown, and may be affected by inaccurate
assumptions. Because of that, we cannot guarantee any forward-looking statement
and actual results may differ materially. It is not possible to foresee or
identify all factors affecting Medtronic's or AVE's respective forward-looking
statements, and investors therefore should not consider any list of factors
affecting Medtronic's or AVE's respective forward-looking statements to be an
exhaustive statement of all risks, uncertainties, or potentially inaccurate
assumptions. Neither Medtronic nor AVE undertakes any obligation to update any
forward-looking statement.
 
    Although we cannot give a comprehensive list of all factors that may cause
actual results to differ from Medtronic's or AVE's forward-looking statements,
the factors include:
 
    - trends toward managed care, health care cost containment, and other
      changes in government and private sector initiatives, in the United States
      and other countries in which Medtronic or AVE do business, that are
      placing increased emphasis on the delivery of more cost-effective medical
      therapies;
 
    - the trend of consolidation in the medical device industry as well as among
      customers of medical device manufacturers, resulting in more significant,
      complex, and long-term contracts than in the past and potentially greater
      pricing pressures;
 
    - the difficulties and uncertainties associated with the lengthy and costly
      new product development and regulatory approval processes, which may
      result in lost market opportunities or preclude product commercialization;
 
    - efficacy or safety concerns with respect to marketed products, whether
      scientifically justified or not, that may lead to product recalls,
      withdrawals, or declining sales;
 
    - changes in governmental laws, regulations, and accounting standards and
      the enforcement thereof that may be adverse to Medtronic or AVE;
 
    - increased public interest in recent years in product liability claims for
      implanted medical devices, including pacemakers and leads, and adverse
      developments in certain litigation involving Medtronic or AVE;
 
    - other legal factors including environmental concerns and patent disputes
      with competitors;
 
    - agency or government actions or investigations affecting the industry in
      general or Medtronic or AVE in particular;
 
    - the development of new products or technologies by competitors,
      technological obsolescence, and other changes in competitive factors;
 
    - risks associated with maintaining and expanding international operations;
 
    - business acquisitions, dispositions, discontinuations or restructurings by
      Medtronic or AVE;
 
    - the integration of businesses acquired by Medtronic or AVE;
 
                                       53
<PAGE>
    - the price and volume fluctuations in the stock markets and their effect on
      the market prices of technology and health care companies; and
 
    - economic factors over which neither Medtronic nor AVE has any control,
      including changes in inflation, foreign currency rates, and interest
      rates.
 
Medtronic and AVE note these factors as permitted by the Private Securities
Litigation Reform Act of 1995.
 
                                       54
<PAGE>
                                    ANNEX A
 
                          AGREEMENT AND PLAN OF MERGER
                                  BY AND AMONG
                                MEDTRONIC, INC.,
                               MAV MERGER CORP.,
                                      AND
                      ARTERIAL VASCULAR ENGINEERING, INC.
 
                               NOVEMBER 29, 1998
 
                                      A-1
<PAGE>
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                                                                              PAGE
                                                                                                            ---------
<S>                                                                                                         <C>
ARTICLE 1 THE MERGER; CONVERSION OF SHARES................................................................        A-5
    1.1 The Merger........................................................................................        A-5
    1.2 Effective Time....................................................................................        A-5
    1.3 Conversion of Shares..............................................................................        A-5
    1.4 No Appraisal Rights...............................................................................        A-6
    1.5 Exchange of Company Common Stock..................................................................        A-6
    1.6 Exchange of Merger Subsidiary Common Stock........................................................        A-8
    1.7 Stock Options.....................................................................................        A-8
    1.8 Capitalization Changes............................................................................       A-10
    1.9 Certificate of Incorporation of the Surviving Corporation.........................................       A-10
    1.10 Bylaws of the Surviving Corporation..............................................................       A-10
    1.11 Directors and Officers of the Surviving Corporation..............................................       A-10
 
ARTICLE 2 CLOSING.........................................................................................       A-10
    2.1 Time and Place....................................................................................       A-10
    2.2 Filings at the Closing............................................................................       A-10
 
ARTICLE 3 REPRESENTATIONS AND WARRANTIES OF THE COMPANY...................................................       A-10
    3.1 Organization......................................................................................       A-11
    3.2 Authorization.....................................................................................       A-11
    3.3 Capitalization....................................................................................       A-12
    3.4 Reports and Financial Statements..................................................................       A-13
    3.5 Absence of Undisclosed Liabilities................................................................       A-13
    3.6 Consents and Approvals............................................................................       A-13
    3.7 Compliance with Laws..............................................................................       A-14
    3.8 Litigation........................................................................................       A-14
    3.9 Absence of Material Adverse Changes...............................................................       A-15
    3.10 Officers, Directors and Employees................................................................       A-15
    3.11 Taxes............................................................................................       A-15
    3.12 Contracts........................................................................................       A-16
    3.13 Intellectual Property Rights.....................................................................       A-16
    3.14 Benefit Plans....................................................................................       A-17
    3.15 Minute Books.....................................................................................       A-18
    3.16 No Finders.......................................................................................       A-18
    3.17 Proxy Statement..................................................................................       A-18
    3.18 Fairness Opinion.................................................................................       A-19
    3.19 State Takeover Laws; Rights Plan.................................................................       A-19
    3.20 Merger Filings...................................................................................       A-19
 
ARTICLE 4 REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUBSIDIARY..................................       A-19
    4.1 Organization......................................................................................       A-19
    4.2 Authorization.....................................................................................       A-20
</TABLE>
 
                                      A-2
<PAGE>
<TABLE>
<S>                                                                                                         <C>
    4.3 Capitalization....................................................................................       A-20
    4.4 Consents and Approvals............................................................................       A-20
    4.5 Reports; Financial Statements; Absence of Changes.................................................       A-21
    4.6 Registration Statement............................................................................       A-21
    4.7 No Finders........................................................................................       A-22
    4.8 Absence of Undisclosed Liabilities................................................................       A-22
    4.9 Compliance with Laws..............................................................................       A-22
    4.10 Litigation.......................................................................................       A-22
    4.11 Absence of Material Adverse Changes..............................................................       A-22
    4.12 Reorganization...................................................................................       A-23
    4.13 Merger Filings...................................................................................       A-23
 
ARTICLE 5 COVENANTS.......................................................................................       A-23
    5.1 Conduct of Business of the Company................................................................       A-23
    5.2 Conduct of Business of Parent.....................................................................       A-25
    5.3 No Solicitation...................................................................................       A-26
    5.4 Access and Information............................................................................       A-27
    5.5 Approval of Stockholders; Proxy Statement; Registration Statement.................................       A-28
    5.6 Consents..........................................................................................       A-29
    5.7 Affiliates' Letters...............................................................................       A-29
    5.8 Expenses..........................................................................................       A-30
    5.9 Further Actions...................................................................................       A-30
    5.10 Regulatory Approvals.............................................................................       A-30
    5.11 Certain Notifications............................................................................       A-30
    5.12 Voting of Shares.................................................................................       A-31
    5.13 Stock Option Agreement...........................................................................       A-31
    5.14 NYSE Listing Application.........................................................................       A-31
    5.15 Indemnification..................................................................................       A-31
    5.16 Letters of the Company's and Parent's Accountants................................................       A-32
    5.17 Subsidiary Shares................................................................................       A-32
    5.18 Benefit Plans and Employee Matters...............................................................       A-32
    5.19 Obligations of Merger Subsidiary.................................................................       A-33
    5.20 Plan of Reorganization...........................................................................       A-33
    5.21 Pooling..........................................................................................       A-33
    5.22 Tax Matters......................................................................................       A-33
 
ARTICLE 6 CLOSING CONDITIONS..............................................................................       A-33
    6.1 Conditions to Obligations of Parent, Merger Subsidiary, and the Company...........................       A-33
    6.2 Conditions to Obligations of Parent and Merger Subsidiary.........................................       A-34
    6.3 Conditions to Obligation of the Company...........................................................       A-35
 
ARTICLE 7 TERMINATION AND ABANDONMENT.....................................................................       A-35
    7.1 Termination.......................................................................................       A-35
    7.2 Effect of Termination.............................................................................       A-37
</TABLE>
 
                                      A-3
<PAGE>
<TABLE>
<S>                                                                                                         <C>
ARTICLE 8 MISCELLANEOUS...................................................................................       A-38
    8.1 Amendment and Modification........................................................................       A-38
    8.2 Waiver of Compliance; Consents....................................................................       A-38
    8.3 Investigation; Survival of Representations and Warranties.........................................       A-39
    8.4 Notices...........................................................................................       A-39
    8.5 Assignment........................................................................................       A-39
    8.6 Governing Law.....................................................................................       A-40
    8.7 Counterparts......................................................................................       A-40
    8.8 Knowledge.........................................................................................       A-40
    8.9 Interpretation....................................................................................       A-40
    8.10 Publicity........................................................................................       A-40
    8.11 Entire Agreement.................................................................................       A-40
    8.12 Severability.....................................................................................       A-40
    8.13 Specific Performance.............................................................................       A-41
 
EXHIBITS:
 
Exhibit A: Certificate of Incorporation
Exhibit B: Form of Affiliate's Letter
Exhibit C: Form of Agreement to Facilitate Merger
Exhibit D: Form of Stock Option Agreement
</TABLE>
 
                                      A-4
<PAGE>
                          AGREEMENT AND PLAN OF MERGER
 
    THIS AGREEMENT is dated as of November 29, 1998, by and among MEDTRONIC,
INC., a Minnesota corporation ("Parent"), MAV MERGER CORP., a Delaware
corporation and wholly owned subsidiary of Parent ("Merger Subsidiary"), and
ARTERIAL VASCULAR ENGINEERING, INC., a Delaware corporation (the "Company").
 
    WHEREAS, the Boards of Directors of Parent, Merger Subsidiary, and the
Company have approved the merger of Merger Subsidiary with and into the Company
(the "Merger") upon the terms and subject to the conditions set forth herein;
and
 
    WHEREAS, for federal income tax purposes, it is intended that the Merger
shall qualify as a reorganization within the meaning of Section 368(a) of the
Internal Revenue Code of 1986, as amended (the "Code"); and
 
    WHEREAS, for accounting purposes, it is intended that the Merger shall be
recorded as a "pooling of interests" within the meaning of Accounting Principles
Board Opinion No. 16, and the rules and regulations of the Securities and
Exchange Commission (the "SEC"); and
 
    WHEREAS, as a condition to, and upon or immediately following the execution
of, this Agreement, Parent and the Company are entering into the Stock Option
Agreement described in Section 5.13 hereof; and
 
    WHEREAS, the parties hereto desire to make certain representations,
warranties, and agreements in connection with the Merger and also to prescribe
various conditions to the Merger;
 
    NOW, THEREFORE, in consideration of the foregoing premises and the mutual
representations, warranties, covenants, and agreements contained herein, the
parties hereto agree as follows:
 
                                   ARTICLE 1
                        THE MERGER; CONVERSION OF SHARES
 
    1.1  THE MERGER.  Subject to the terms and conditions of this Agreement, at
the Effective Time (as defined in Section 1.2 hereof), Merger Subsidiary shall
be merged with and into the Company in accordance with the provisions of the
Delaware General Corporation Law (the "DGCL"), whereupon the separate corporate
existence of Merger Subsidiary shall cease, and the Company shall continue as
the surviving corporation (the "Surviving Corporation"). From and after the
Effective Time, the Surviving Corporation shall possess all the rights,
privileges, powers, and franchises and be subject to all the restrictions,
disabilities, and duties of the Company and Merger Subsidiary, all as more fully
described in the DGCL.
 
    1.2  EFFECTIVE TIME.  As soon as practicable after each of the conditions
set forth in Article 6 has been satisfied or waived on the Closing Date (as
defined in Section 2.1), the Company will file, or cause to be filed, with the
Secretary of State of the State of Delaware a Certificate of Merger for the
Merger, which Certificate shall be in the form required by and executed in
accordance with the applicable provisions of the DGCL. The Merger shall become
effective at the time such filing is made or, if agreed to by Parent and the
Company, such later time or date set forth in the Certificate of Merger (the
"Effective Time").
 
    1.3  CONVERSION OF SHARES.  At the Effective Time, by virtue of the Merger
and without any action on the part of the Company, Parent, Merger Subsidiary or
any holder of any share of capital stock of the Company or Merger Subsidiary:
 
        (a) Each share of common stock of the Company, $.001 par value per share
    ("Company Common Stock"), issued and outstanding immediately prior thereto
    (except for shares referred to in Section 1.3(b) hereof) shall be converted,
    subject to Section 1.5(f), into the right to receive a number of shares
    (carried out to five decimal places and rounded up if the sixth decimal
    place is 5 or greater) (the "Conversion Ratio") of common stock of Parent,
    par value $.10 per share (the "Parent Common
 
                                      A-5
<PAGE>
    Stock"), based on the average (rounded to the nearest full cent, with the
    cents rounded up if the third decimal place is 5 or more) of the daily
    closing sale prices of a share of Parent Common Stock as reported on the New
    York Stock Exchange ("NYSE") Composite Tape, as reported in The Wall Street
    Journal (the "Parent Average Stock Price"), for the fifteen consecutive NYSE
    trading days ending on and including the NYSE trading day that is two NYSE
    trading days prior to the Company Stockholders Meeting (as defined in
    Section 5.5) (the "Determination Period"), determined as follows:
 
           (i) if the Parent Average Stock Price for the Determination Period is
       greater than $61.20 and less than $74.80, then the Conversion Ratio shall
       equal $54.00 divided by the Parent Average Stock Price for the
       Determination Period;
 
           (ii) if the Parent Average Stock Price for the Determination Period
       is equal to or less than $61.20, then the Conversion Ratio shall equal
       0.88235; or
 
           (iii) if the Parent Average Stock Price for the Determination Period
       is equal to or greater than $74.80, then the Conversion Ratio shall equal
       0.72193.
 
        An appropriate adjustment to the Conversion Ratio shall be made in the
    event that, prior to the Effective Time, the outstanding shares of Company
    Common Stock, without new consideration, are changed into or exchanged for a
    different number of shares or a different class by reason of any
    reorganization, reclassification, subdivision, recapitalization, split-up,
    combination, exchange of shares, stock dividend or other similar
    transaction. Notwithstanding the foregoing, nothing in this section shall be
    deemed to constitute authorization or permission for or consent from Parent
    or Merger Subsidiary to any reorganization, reclassification, subdivision,
    recapitalization, split-up, combination, exchange of shares, or other
    similar transaction.
 
        (b) Each share of Company Common Stock issued and outstanding
    immediately prior to the Effective Time that is held in the treasury of the
    Company or is then owned beneficially or of record by Parent, Merger
    Subsidiary, or any direct or indirect wholly owned subsidiary of Parent or
    the Company shall be canceled in accordance with applicable laws without
    payment of any consideration therefor and without any conversion thereof.
 
        (c) Each share of any other class of capital stock of the Company (other
    than Company Common Stock) shall be canceled without payment of any
    consideration therefor and without any conversion thereof.
 
        (d) Each share of common stock of Merger Subsidiary, par value $.01 per
    share ("Merger Subsidiary Common Stock"), issued and outstanding immediately
    prior to the Effective Time shall be converted into one share of the common
    stock of the Surviving Corporation, par value $.01 per share ("Surviving
    Corporation Common Stock").
 
    1.4  NO APPRAISAL RIGHTS.  The parties acknowledge that, pursuant to Section
262 of the DGCL, no holders of Company Common Stock shall have appraisal rights
in connection with the Merger.
 
    1.5  EXCHANGE OF COMPANY COMMON STOCK.
 
        (a) At or prior to the Effective Time, Parent shall cause Parent's stock
    transfer agent or such other person as Parent may appoint and is reasonably
    satisfactory to the Company to act as exchange agent (the "Exchange Agent")
    hereunder. As promptly as practicable after the Effective Time, Parent shall
    cause the Exchange Agent to mail to each holder of record (other than
    Parent, Merger Subsidiary, the Company, or any wholly owned subsidiary of
    Parent or the Company) of a certificate or certificates that immediately
    prior to the Effective Time represented outstanding shares of Company Common
    Stock ("Company Certificates") a form letter of transmittal (which shall
    specify that delivery shall be effective, and risk of loss and title to the
    Company Certificate(s) shall pass, only upon delivery of the Company
    Certificate(s) to the Exchange Agent) and instructions for such holder's use
    in effecting the surrender of the Company Certificates in exchange for
    certificates representing shares of Parent Common Stock and cash in lieu of
    any fractional shares.
 
                                      A-6
<PAGE>
        (b) As soon as practicable after the Effective Time, the Exchange Agent
    shall distribute to holders of shares of Company Common Stock, upon
    surrender to the Exchange Agent of one or more Company Certificates for
    cancellation, together with a duly-executed letter of transmittal, (i) one
    or more certificates representing the number of whole shares of Parent
    Common Stock into which the shares represented by the Company Certificate(s)
    shall have been converted pursuant to Section 1.3(a), (ii) a bank check in
    the amount of cash into which the shares represented by the Company
    Certificate(s) shall have been converted pursuant to Section 1.5(f)
    (relating to fractional shares), and (iii) any dividends or other
    distributions to which such holder is entitled pursuant to Section 1.5(c),
    and the Company Certificate(s) so surrendered shall be canceled. In the
    event of a transfer of ownership of Company Common Stock that is not
    registered in the transfer records of the Company, it shall be a condition
    to the issuance of shares of Parent Common Stock that the Company
    Certificate(s) so surrendered shall be properly endorsed or be otherwise in
    proper form for transfer and that such transferee shall (i) pay to the
    Exchange Agent any transfer or other taxes required or (ii) establish to the
    satisfaction of the Exchange Agent that such tax has been paid or is not
    payable.
 
        (c) Holders of Company Common Stock will be entitled to any dividends or
    other distributions pertaining to the Parent Common Stock received in
    exchange therefor that become payable to persons who are holders of record
    of Parent Common Stock as of a record date that follows the Effective Time,
    but only after they have surrendered their Company Certificates for
    exchange. Subject to the effect, if any, of applicable law, the Exchange
    Agent shall receive, hold, and remit any such dividends or other
    distributions to each such record holder entitled thereto, without interest,
    at the time that such Company Certificates are surrendered to the Exchange
    Agent for exchange. Holders of Company Common Stock will not be entitled,
    however, to dividends or other distributions that become payable before or
    after the Effective Time to persons who were holders of record of Parent
    Common Stock as of a record date that is prior to the Effective Time.
 
        (d) All certificates evidencing shares of Parent Common Stock that are
    issued upon the surrender for exchange of Company Certificates in accordance
    with the terms hereof, together with any cash paid for fractional shares
    pursuant to Section 1.5(f) hereof, shall be deemed to have been issued in
    full satisfaction of all rights pertaining to the shares of Company Common
    Stock represented by the surrendered Company Certificates.
 
        (e) After the Effective Time, there shall be no further registration of
    transfers on the stock transfer books of the Surviving Corporation of the
    shares of Company Common Stock that were outstanding immediately prior to
    the Effective Time. If, after the Effective Time, Company Certificates
    representing such shares are presented to the Surviving Corporation, they
    shall be canceled and exchanged as provided in this Article 1. As of the
    Effective Time, the holders of Company Certificates representing shares of
    Company Common Stock shall cease to have any rights as stockholders of the
    Company, except such rights, if any, as they may have pursuant to the DGCL
    or this Agreement. Except as provided above, until such Company Certificates
    are surrendered for exchange, each such Company Certificate shall, after the
    Effective Time, represent for all purposes only the right to receive a
    certificate or certificates evidencing the number of whole shares of Parent
    Common Stock into which the shares of Company Common Stock shall have been
    converted pursuant to the Merger as provided in Section 1.3(a) hereof, the
    right to receive the cash value of any fraction of a share of Parent Common
    Stock as provided in Section 1.5(f) hereof and the right to receive any
    dividends or distributions as provided in Section 1.5(c).
 
        (f) No fractional shares of Parent Common Stock and no certificates or
    scrip therefor, or other evidence of ownership thereof, shall be issued in
    connection with the Merger, no dividend or other distribution of Parent
    shall relate to any fractional share, and such fractional share interests
    shall not entitle the owner thereof to vote or to any rights of a
    shareholder of Parent. All fractional shares of Parent Common Stock to which
    a holder of Company Common Stock immediately prior to the Effective Time
    would otherwise be entitled, at the Effective Time, shall be aggregated if
    and to the
 
                                      A-7
<PAGE>
    extent multiple Company Certificates of such holder are submitted together
    to the Exchange Agent. If a fractional share results from such aggregation,
    then (in lieu of such fractional share) the Exchange Agent shall pay to each
    holder of shares of Company Common Stock who otherwise would be entitled to
    receive such fractional share of Parent Common Stock an amount of cash
    (without interest) determined by multiplying (i) the closing sale price of a
    share of Parent Common Stock as reported on the NYSE Composite Tape, as
    reported in The Wall Street Journal, on the Closing Date by (ii) the
    fractional share of Parent Common Stock to which such holder would otherwise
    be entitled. Parent will make available to the Exchange Agent any cash
    necessary for this purpose.
 
        (g) In the event any Company Certificates shall have been lost, stolen,
    or destroyed, the Exchange Agent shall issue in respect of such lost,
    stolen, or destroyed Company Certificates, upon the making of an affidavit
    of that fact by the holder thereof, such shares of Parent Common Stock, cash
    for fractional shares, if any, and dividends or other distributions, if any,
    as may be required pursuant to this Article 1; provided, however, that
    Parent may, in its discretion and as a condition precedent to the issuance
    thereof, require the owner of such lost, stolen, or destroyed Company
    Certificate to deliver a bond in such sum as Parent may reasonably direct as
    indemnity against any claim that may be made against Parent or the Exchange
    Agent with respect to such Company Certificate alleged to have been lost,
    stolen, or destroyed.
 
        (h) The parties hereto acknowledge that each certificate representing a
    share of Parent Common Stock issued pursuant to this Article 1 will,
    pursuant to the Rights Agreement dated as of June 27, 1991, between Parent
    and Norwest Bank Minnesota, N.A. (the "Parent Rights Plan"), also represent
    the number of Parent preferred share purchase rights associated with one
    share of Parent Common Stock at the Effective Time.
 
    1.6  EXCHANGE OF MERGER SUBSIDIARY COMMON STOCK.  From and after the
Effective Time, each outstanding certificate previously representing shares of
Merger Subsidiary Common Stock shall be deemed for all purposes to evidence
ownership of and to represent the number of shares of Surviving Corporation
Common Stock into which such shares of Merger Subsidiary Common Stock shall have
been converted. Promptly after the Effective Time, the Surviving Corporation
shall issue to Parent a stock certificate or certificates representing such
shares of Surviving Corporation Common Stock in exchange for the certificate or
certificates that formerly represented shares of Merger Subsidiary Common Stock,
which shall be canceled.
 
    1.7  STOCK OPTIONS.
 
        (a) Except as provided in (c) below with respect to the Company's 1997
    Employee Stock Purchase Plan, as amended (the "Company ESPP"), each option
    to purchase shares of Company Common Stock that is outstanding at the
    Effective Time, whether or not exercisable and whether or not vested (a
    "Company Option") shall, without any action on the part of the Company or
    the holder thereof, be assumed by Parent in such manner that Parent (i) is a
    corporation "assuming a stock option in a transaction to which Section
    424(a) applies" within the meaning of Section 424 of the Code and the
    regulations thereunder or (ii) to the extent that Section 424 of the Code
    does not apply to any such Company Option, would be such a corporation were
    Section 424 of the Code applicable to such Company Option. From and after
    the Effective Time, all references to the Company in the Company Options
    shall be deemed to refer to Parent. The Company Options assumed by Parent
    shall be exercisable upon the same terms and conditions as under the Company
    Options (including provisions regarding vesting and the acceleration
    thereof) except that (i) such Company Options shall entitle the holder to
    purchase from Parent the number of shares of Parent Common Stock (rounded
    down to the nearest whole number of such shares) that equals the product of
    the Conversion Ratio multiplied by the number of shares of Company Common
    Stock subject to such Company Option immediately prior to the Effective
    Time, (ii) the option exercise price per share of Parent Common Stock shall
    be an amount (rounded up to the nearest full cent) equal to the option
    exercise price per share of Company Common Stock in effect immediately prior
    to the Effective Time divided by the
 
                                      A-8
<PAGE>
    Conversion Ratio, and (iii) the Company Options shall vest to the extent
    required pursuant to the current terms of such Company Options or other
    agreements as described in Section 1.7 of the Company Disclosure Schedule
    (as defined below); provided that if such vesting of Company Options or
    other provisions with respect to the Company Options would jeopardize the
    Merger being accounted for as a "pooling of interests", then the Company
    shall, subject to Parent's written consent not to be unreasonably withheld,
    use reasonable best efforts to prevent such vesting or effect of other
    provisions. Except to the extent required pursuant to the current terms of
    such Company Options or other agreements as described in Section 1.7 of the
    Company Disclosure Schedule (as defined below), the Company shall not take
    any action to accelerate the vesting of any Company Options. Prior to the
    Effective Time, the Board of Directors of Parent shall, for purposes of Rule
    16b-3(d)(1) promulgated under Section 16 of the Securities Exchange Act of
    1934, and the rules and regulations thereunder (the "1934 Act"),
    specifically approve (i) the assumption by Parent of the Company Options and
    (ii) the issuance of Parent Common Stock in the Merger to directors,
    officers and stockholders of the Company subject to Section 16 of the 1934
    Act.
 
        (b) As promptly as practicable after the Effective Time, Parent shall
    issue to each holder of a Company Option a written instrument informing such
    holder of the assumption by Parent of such Company Option. As soon as
    reasonably practicable after the Effective Time (and in any event no later
    than five business days after the Effective Time, provided current option
    information required therefor is delivered to Parent at the Effective Time),
    Parent shall file a registration statement on Form S-8 (or any successor
    form) with respect to the shares of Parent Common Stock subject to Company
    Options and shall use commercially reasonable efforts to maintain such
    registration statement (or any successor form), including the current status
    of any related prospectus or prospectuses, for so long as the Company
    Options remain outstanding. In addition, Parent shall use commercially
    reasonable efforts to cause the shares of Parent Common Stock subject to
    Company Options to be listed on the NYSE and such other exchanges as Parent
    shall determine. Parent shall take all corporate action necessary to reserve
    for issuance a sufficient number of shares of Parent Common Stock for
    delivery upon exercise of Company Options pursuant to the terms set forth in
    this Section 1.7. Parent shall comply with the terms of the Company Stock
    Option Plans (as defined in Section 3.3) and use commercially reasonable
    efforts to cause those Company Options which qualified as incentive stock
    options prior to the Effective Time to continue to qualify as incentive
    stock options immediately after the Effective Time.
 
        (c) The current offerings in process as of the date of this Agreement
    under the Company ESPP shall continue, and shares shall be issued to
    participants thereunder on the next currently scheduled purchase dates
    thereunder occurring after the date hereof as provided under, and subject to
    the terms and conditions of, the Company ESPP. The Company may, consistent
    with past practice, commence a new offering period under the Company ESPP on
    or after February 1, 1999 and prior to the Effective Time at an exercise
    price for such offering not less than as is required under the Company ESPP.
    Immediately prior to the Effective Time, pursuant to Section 12(b) of the
    Company ESPP, all offerings under the Company ESPP shall be terminated, and
    each participant shall be deemed to have purchased immediately prior to the
    Effective Time, to the extent of payroll deductions accumulated by such
    participant as of such offering period end, the number of whole shares of
    Company Common Stock at a per share price determined pursuant to the
    provisions of the Company ESPP, and each participant shall receive a cash
    payment equal to the balance, if any, of such accumulated payroll deductions
    remaining after such purchase of such shares. As of the Effective Time, each
    participant shall receive, by virtue of the Merger, the number of whole
    shares of Parent Common Stock into which the shares of Company Common Stock
    such participant has so purchased under the Company ESPP have been converted
    pursuant to the Merger as provided in Section 1.3(a) hereof, plus the cash
    value of any fraction of a share of Parent Common Stock as provided in
    Section 1.5(f) hereof, plus any dividends or distributions as provided in
    Section 1.5(c). The Company ESPP and all purchase rights thereunder shall
    terminate effective as of the Effective Time.
 
                                      A-9
<PAGE>
    1.8  CAPITALIZATION CHANGES.  If, between the date of this Agreement and the
Effective Time, the outstanding shares of Parent Common Stock shall have been
changed into or exchanged for a different number of shares or a different class
by reason of any reorganization, reclassification, subdivision,
recapitalization, split-up, combination, exchange of shares, stock dividend or
other similar transaction, the Conversion Ratio and all per-share price amounts
and calculations set forth in this Agreement shall be appropriately adjusted to
reflect such reorganization, reclassification, subdivision, recapitalization,
split-up, combination, exchange of shares, stock dividend or other similar
transaction.
 
    1.9  CERTIFICATE OF INCORPORATION OF THE SURVIVING CORPORATION.  The
Certificate of Incorporation of the Company, as in effect immediately prior to
the Effective Time, shall be amended to read as set forth on EXHIBIT A to this
Agreement.
 
    1.10  BYLAWS OF THE SURVIVING CORPORATION.  The Bylaws of Merger Subsidiary,
as in effect immediately prior to the Effective Time, shall, subject to Section
5.15, be the Bylaws of the Surviving Corporation until thereafter amended in
accordance with applicable law.
 
    1.11  DIRECTORS AND OFFICERS OF THE SURVIVING CORPORATION.  The directors
and officers of Merger Subsidiary immediately prior to the Effective Time shall
be the directors and officers, respectively, of the Surviving Corporation until
their respective successors shall be duly elected and qualified.
 
                                   ARTICLE 2
                                    CLOSING
 
    2.1  TIME AND PLACE.  Subject to the satisfaction or waiver of the
provisions of Article 6, the closing of the Merger (the "Closing") shall take
place at 1:00 p.m., local time, on the date that the Required Company
Stockholder Vote (as defined in Section 3.2) is obtained, or as soon thereafter
as, and in any event no later than the second business day after, all conditions
to Closing have been satisfied or waived, or on such other date and/or at such
other time as Parent and the Company may mutually agree. The date on which the
Closing actually occurs is herein referred to as the "Closing Date." The Closing
shall take place at the corporate headquarters offices of Parent, or at such
other place or in such other manner (e.g., by telecopy exchange of signature
pages with originals to follow by overnight delivery) as the parties hereto may
agree.
 
    2.2  FILINGS AT THE CLOSING.  At the Closing, subject to the provisions of
Article 6, Parent, Merger Subsidiary, and the Company shall cause the
Certificate of Merger to be filed in accordance with the provisions of Section
252 of the DGCL, and take any and all other lawful actions and do any and all
other lawful things necessary to cause the Merger to become effective.
 
                                   ARTICLE 3
                 REPRESENTATIONS AND WARRANTIES OF THE COMPANY
 
    Except: (i) as set forth in a document of even date herewith and
concurrently delivered herewith (the "Company Disclosure Schedule"); (ii) as
specifically described through express disclosure of current, specific facts set
forth in the Company's Annual Report on Form 10-K for the fiscal year ended June
30, 1998 or in any other filing by the Company with the SEC (as defined in
Section 3.4) filed after the date of filing such Form 10-K and prior to the date
hereof and the Company's Registration Statement on Form S-4 with respect to the
acquisition of World Medical (as defined below) as amended or supplemented prior
to the date hereof and previously delivered to Parent; (iii) as specifically
described in the schedules referred to in Section 3.1 of the Stock and Asset
Purchase Agreement dated July 9, 1998 between C. R. Bard, Inc. and the Company
(the "Bard Schedules"), as amended or supplemented prior to the date hereof and
previously delivered to Parent; or (iv) as specifically described in the
Disclosure Schedule delivered pursuant to Article 2 of the Agreement and Plan of
Merger and Reorganization dated April 10, 1998 between World Medical
Manufacturing Corporation ("World Medical"), Walleye Acquisition Corporation and
the Company (the "World Medical Schedules"), as amended or supplemented prior to
the date hereof
 
                                      A-10
<PAGE>
and previously delivered to Parent (for purposes of clauses (i), (ii), (iii) and
(iv) above, disclosures in the Company Disclosure Schedule, such Company SEC
filings, the Bard Schedules or the World Medical Schedules shall be deemed to
qualify or limit only those particular representations and warranties set forth
in this Article 3 to which the relevancy of such disclosures is readily
apparent); the Company hereby makes the following representations and warranties
to Parent and Merger Subsidiary:
 
    3.1  ORGANIZATION.  The Company and each subsidiary of the Company (referred
to herein as a "Subsidiary") is an entity duly organized, validly existing, and
in good standing (where such concept is recognized) under the laws of its
respective jurisdiction of organization and has all requisite corporate power
and authority to own, lease, and operate its properties and to carry on its
business as now being conducted, except where the failure to be so organized,
existing or in good standing or to have such corporate power and authority would
not, individually or in the aggregate, have a Company Material Adverse Effect
(as defined below). The Company and each Subsidiary is duly qualified and in
good standing to do business in each jurisdiction in which the property owned,
leased, or operated by it or the nature of the business conducted by it makes
such qualification necessary, except where the failure to be so qualified or in
good standing could not reasonably be expected to have a Company Material
Adverse Effect (as defined below). "Company Material Adverse Effect" means an
effect that, in the aggregate with other favorable and unfavorable effects
arising from breaches of the Company's representations and warranties, is or
would reasonably at the time of such effect be expected to be materially
adverse: (i) to the business, results of operation, or financial condition of
the Company and its Subsidiaries, considered as a whole; (ii) to the ability of
the Surviving Corporation to conduct such business, as presently conducted,
following the Effective Time or the ability of Parent to derive the benefits of
owning all of the stock of the Surviving Corporation; or (iii) to the Company's
ability to perform any of its material obligations under this Agreement or to
consummate the Merger, except in each case for any such effects resulting from
or arising out of (i) this Agreement or the transactions contemplated by this
Agreement or the announcement or pendency of the Merger, (ii) any occurrence or
condition affecting the medical device or stent industries generally, or (iii)
any changes in general economic, regulatory or political conditions, and
provided, that the probability of the Company being indemnified by C.R. Bard,
Inc. against such effects or related losses or expenses (assuming a claim
therefor is asserted as soon as reasonably practicable) shall be taken into
account for purposes of determining whether there has been a Company Material
Adverse Effect. The jurisdictions in which the Company and each Subsidiary are
incorporated are listed in the Company Disclosure Schedule. The Company has
heretofore delivered or made available to Parent or its advisers complete and
accurate copies of the Certificate of Incorporation and Bylaws of the Company,
as currently in effect, and of the organizational documents and agreements
defining the rights of the Company or any Subsidiary with respect to any
material joint ventures, partnerships or other business in which the Company
owns less than substantially all of the outstanding equity interest. As of the
date hereof, neither the Company nor any Subsidiary, directly or indirectly,
owns or controls or has any material equity, partnership, or other similar
ownership interest in any corporation, partnership, joint venture, or other
business association or entity that is material to the Company and its
Subsidiaries, considered as a whole.
 
    3.2  AUTHORIZATION.  The Company has all necessary corporate power and
authority to execute and deliver this Agreement and, subject to obtaining the
necessary approval of its stockholders, to consummate the transactions
contemplated hereby. The execution and delivery by the Company of this Agreement
and the other agreements contemplated hereby to which the Company is a party,
and the consummation by the Company of the transactions contemplated hereby and
thereby, have been duly and validly authorized and approved by the Company's
Board of Directors, no other corporate proceedings on the part of the Company
are necessary to authorize this Agreement, and, subject to obtaining the
approval and adoption of this Agreement and approval of the Merger by a majority
of the shares of the Company Common Stock outstanding as of the record date of
the Company's stockholder meeting (the "Required Company Stockholder Vote"), no
other corporate action on the part of the Company is necessary to consummate the
transactions contemplated hereby. The Merger has been declared advisable by the
Board of Directors of the Company. This Agreement has been duly and validly
executed and delivered by the Company and,
 
                                      A-11
<PAGE>
assuming due execution and delivery by the other parties hereto, constitutes the
valid and binding obligation of the Company, enforceable against the Company in
accordance with its terms, subject to laws of general application relating to
bankruptcy, insolvency, and the relief of debtors and rules of law governing
specific performance, injunctive relief, or other equitable remedies.
 
    3.3  CAPITALIZATION.  As of the close of business on November 25, 1998, the
authorized capital stock of the Company consisted of (i) 300,000,000 shares of
Company Common Stock, $.001 par value per share, of which 64,360,781 were issued
and outstanding and 60,000 shares were held in the Company's treasury, and (ii)
5,000,000 shares of Company Preferred Stock, $.001 par value per share, of which
1,000,000 have been designated as Series A Preferred Stock and none of which
were issued or outstanding. All issued and outstanding shares of capital stock
of each Subsidiary are owned, beneficially and of record, by the Company, free
and clear of any mortgage, pledge, security interest, encumbrance, lien or other
charge of any kind ("Lien") that would materially affect the Company's interest
in such shares. All issued and outstanding shares of Company Common Stock have
been validly issued, are fully paid and nonassessable, and have not been issued
in violation of and are not currently subject to any preemptive rights. Except
for (i) Company Options to purchase an aggregate of 346,332 shares of Company
Common Stock not granted pursuant to any Company Stock Option Plan (as defined
below) and that are listed, together with their respective exercise prices, in
the Company Disclosure Schedule, (ii) Company Options to purchase an aggregate
of 3,901,835 shares of Company Common Stock that were granted pursuant to the
Company's 1996 Equity Incentive Plan and the Company's 1996 Non-Employee
Directors' Stock Option Plan (collectively, the "Company Stock Option Plans")
and that are listed, together with their respective exercise prices, in the
Company Disclosure Schedule, (iii) the rights to purchase shares of Company
Common Stock under the Company ESPP (estimated to be approximately 250,000
shares as of the next purchase date under the Company ESPP, based on the current
contribution rates of the participants for the current Company ESPP offerings in
process as of the date of this Agreement) and (iv) the rights outstanding
pursuant to the Company Rights Agreement (as defined in Section 3.19), as of
November 25, 1998, there were not any outstanding or authorized subscriptions,
options, warrants, calls, rights, convertible securities, commitments,
restrictions, arrangements, or any other agreements of any character to which
the Company or any Subsidiary was a party that, directly or indirectly, (A)
obligated the Company or any Subsidiary to issue any shares of capital stock or
any securities convertible into, or exercisable or exchangeable for, or
evidencing the right to subscribe for, any shares of capital stock, (B) called
for or related to the sale, pledge, transfer, or other disposition or
encumbrance by the Company or any Subsidiary of any shares of its capital stock,
or (C) to the knowledge of the Company, related to the voting or control of such
capital stock. The Company Disclosure Schedule sets forth a complete and
accurate list of all stock options, warrants, and other rights to acquire
Company Common Stock that were outstanding as of November 25, 1998, including
the name of the holder, the date of grant, acquisition price, number of shares,
exercisability schedule, and, in the case of options, the type of option under
the Code. No consent of holders or participants under the Company Stock Option
Plans or the Company ESPP is required to carry out the provisions of Section
1.7. All actions, if any, required on the part of the Company under the Company
Stock Option Plans or the Company ESPP to allow for the treatment of Company
Options and the Company ESPP as is provided in Section 1.7, have been, or prior
to the Closing will be, validly taken by the Company. In no event will the
aggregate number of shares of Company Common Stock outstanding at the Effective
Time (including all shares subject to then outstanding Company Options or other
rights to acquire or commitments to issue shares of Company stock, other than
the Stock Option Agreement referenced in Section 5.13) exceed the sum of (w) the
outstanding shares of Company Common Stock described in the first sentence of
this Section 3.3, plus (x) any shares of Company Common Stock issued upon the
exercise of outstanding options to purchase Company Common Stock identified in
Section 3.3, plus (y) any shares of Company Common Stock issued by the Company
upon the exercise of rights under the Company ESPP, plus (z) any additional
shares identified in Section 3.3 of the Company Disclosure Schedule or permitted
to be issued under Section 5.1(b) hereof.
 
                                      A-12
<PAGE>
    3.4  REPORTS AND FINANCIAL STATEMENTS.  The Company has filed all forms,
reports, registration statements, and other documents required to be filed by it
with the Securities and Exchange Commission ("SEC") since January 1, 1995 (such
forms, reports, registration statements, and documents, together with any
amendments thereto, are referred to as the "Company SEC Filings"). As of their
respective dates, the Company SEC Filings (i) complied as to form in all
material respects with the applicable requirements of the Securities Act of
1933, and the rules and regulations thereunder (the "1933 Act") and the 1934
Act, as the case may be, and (ii) did not contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary to make the statements made therein, in light of the circumstances
under which they were made, not misleading. The audited financial statements
included or incorporated by reference in the Company SEC Filings, including but
not limited to the Company's audited financial statements at and for the year
ended June 30, 1998 (the "Company June 30, 1998 Financials"), and the unaudited
interim financial statements at and for periods commencing on or after July 1,
1998, included or incorporated by reference in the forms, reports, registration
statements and other documents filed by the Company with the SEC (i) were
prepared in accordance with generally accepted accounting principles (except, in
the case of unaudited statements, as permitted by Form 10-Q filed with the SEC)
applied on a consistent basis during the periods involved (except as may be
indicated therein or in the notes thereto), subject, in the case of unaudited
interim financial statements, to the absence of notes and to year-end
adjustments, (ii) complied as of their respective dates in all material respects
with applicable accounting requirements and the published rules and regulations
of the SEC with respect thereto, and (iii) fairly present in all material
respects the consolidated financial position of the Company and its consolidated
subsidiaries as of the dates thereof and the consolidated income, cash flows,
and changes in stockholders' equity of the Company and its consolidated
subsidiaries for the periods involved, except as otherwise noted therein and
subject, in the case of unaudited statements, to normal year-end audit
adjustments. The statements of operations included in the audited or unaudited
interim financial statements in the Company SEC Filings do not contain any items
of special or nonrecurring income or any other income not earned in the ordinary
course of business required to be disclosed separately in accordance with
generally accepted accounting principles, except as expressly specified in the
applicable statement of operations or notes thereto.
 
    3.5  ABSENCE OF UNDISCLOSED LIABILITIES.  To the best of the Company's
knowledge, neither the Company nor any Subsidiary has any liabilities or
obligations of any nature (whether absolute, accrued, contingent or otherwise)
of the type required to be reflected on or reserved against in, or disclosed in
the notes to, a balance sheet prepared in accordance with U.S. generally
accepted accounting principles except: (a) liabilities or obligations that are
accrued or reserved against in the audited consolidated balance sheet of the
Company and its consolidated subsidiaries as of June 30, 1998 contained in the
Company June 30, 1998 Financials (the "Company Audited Balance Sheet") or in the
unaudited consolidated balance sheet of the Company and its consolidated
subsidiaries as of September 30, 1998 contained in the Company's Quarterly
Report on Form 10-Q for the fiscal quarter ended September 30, 1998 (the
"Company Interim Balance Sheet") or referred to in the notes thereto, (b)
liabilities incurred in the ordinary course of business since September 30, 1998
and (c) liabilities or obligations that could not reasonably be expected to have
a Company Material Adverse Effect.
 
    3.6  CONSENTS AND APPROVALS.  Except for: (i) any applicable requirements of
the 1933 Act, the 1934 Act, state securities laws, the Hart-Scott-Rodino
Antitrust Improvements Act of 1976 and the regulations thereunder (the "HSR
Act"), and the antitrust, competition, foreign investment, or similar laws of
any foreign countries or supranational commissions or boards that require
pre-merger notifications or filings with respect to the Merger (collectively,
"Foreign Merger Laws"), (ii) obtaining the Required Company Stockholder Vote and
any stockholder vote necessary under the requirements of Nasdaq with respect to
issuance of shares of Company Common Stock pursuant to the Stock Option
Agreement described in Section 5.13, (iii) the filing and recordation of
appropriate merger documents as required by the DGCL, the execution and delivery
by the Company of this Agreement and the other agreements contemplated hereby to
which the Company is a party and the consummation by the Company of the
transactions
 
                                      A-13
<PAGE>
contemplated hereby and thereby will not: (a) violate any provision of the
Certificate or Articles of Incorporation or Bylaws of the Company or any
Subsidiary; (b) violate any material statute, rule, regulation, order, or decree
of any federal, state, local, or foreign governmental or regulatory body or
authority (including, but not limited to, the Food and Drug Administration (the
"FDA")) (a "Governmental Body") or any nongovernmental self-regulatory agency by
which the Company or any Subsidiary, or any of their respective properties or
assets may be bound; (c) require any filing by the Company with or permit,
consent, or approval to be obtained by the Company from any Governmental Body or
any nongovernmental self-regulatory agency; or (d) result in any violation or
breach of, or constitute (with or without due notice or lapse of time or both) a
default under, result in the loss of any material benefit under, or give rise to
any right of termination, cancellation, increased payments, or acceleration
under, or result in the creation of any Lien (as defined in Section 3.3) on any
of the properties or assets of the Company or any Subsidiary under, any of the
terms, conditions, or provisions of any note, bond, mortgage, indenture,
license, franchise, permit, authorization, agreement, or other instrument or
obligation to which the Company or any Subsidiary is a party, or by which it or
any of its properties or assets may be bound, except, in the case of clauses (c)
and (d), for any such filings, permits, consents or approvals or violations,
breaches, defaults, or other occurrences that could not reasonably be expected
to prevent or delay consummation of any of the transactions contemplated hereby
in any material respect, or otherwise prevent the Company from performing its
obligations under this Agreement in any material respect, and could not
reasonably be expected to have a Company Material Adverse Effect. Section 3.6 of
the Company Disclosure Schedule lists each note, bond, mortgage, indenture,
license, franchise, permit, authorization, agreement, or other instrument or
obligation to which the Company or any Subsidiary is a party, or by which it or
any of its properties or assets may be bound and which is material to the
Company and its Subsidiaries, considered as a whole, under or with respect to
which the transactions contemplated by this Agreement will result in any
material violation or breach of, or constitute (with or without due notice or
lapse of time or both) a material default under, result in the loss of any
material benefit under, or give rise to any material right of termination,
cancellation, increased payments, or acceleration under, or result in the
creation of any material Lien on any of the material properties or assets of the
Company or any Subsidiary.
 
    3.7  COMPLIANCE WITH LAWS.  Neither the Company nor any Subsidiary is in
default or violation of any applicable federal, state, local, or foreign laws,
ordinances, regulations, interpretations, judgments, decrees, injunctions,
permits, licenses, certificates, governmental requirements, orders, or other
similar items of any court or other Governmental Body (and including those of
any nongovernmental self-regulatory agency and including environmental laws or
regulations), except for such defaults or violations that could not reasonably
be expected to have a Company Material Adverse Effect. The Company and each
Subsidiary have timely filed or otherwise provided all registrations, reports,
data, and other information and applications with respect to its medical device,
pharmaceutical, consumer, health care, and other governmentally regulated
products (the "Regulated Products") required to be filed with or otherwise
provided to the FDA or any other Governmental Body with jurisdiction over the
manufacture, use, or sale of the Regulated Products, and all regulatory licenses
or approvals in respect thereof are in full force and effect, except where the
failure to file timely such registrations, reports, data, information, and
applications or the failure to have such licenses and approvals in full force
and effect could not reasonably be expected to have a Company Material Adverse
Effect.
 
    3.8  LITIGATION.
 
        (a) As of the date of this Agreement, there is no Merger-Related
    Proceeding pending, or to the knowledge of the Company, threatened in
    writing against the Company. (For purposes of this Agreement,
    "Merger-Related Proceeding" shall mean any meritorious asserted claim,
    action, suit, proceeding, or to the Company's knowledge, governmental
    investigation or governmental review of any kind: (i) challenging or seeking
    to prevent, enjoin or delay the Merger or any of the other transactions
    contemplated by this Agreement, or (ii) seeking material damages from the
    Company or
 
                                      A-14
<PAGE>
    any of its Subsidiaries or from Parent or any of its subsidiaries in
    connection with the consummation or anticipated consummation of the Merger.)
 
        (b) There are no meritorious asserted claims, actions, suits,
    proceedings or, to the knowledge of the Company, governmental investigations
    or governmental reviews of any kind pending, or to the knowledge of the
    Company, threatened in writing against the Company or any Subsidiary or any
    asset or property of the Company or any Subsidiary, other than
    Merger-Related Proceedings and except for such claims, actions, suits,
    proceedings, governmental investigations or governmental reviews that could
    not reasonably be expected to have a Company Material Adverse Effect.
 
    3.9  ABSENCE OF MATERIAL ADVERSE CHANGES.  Between June 30, 1998 and the
date hereof, there has not been any (a) Company Material Adverse Effect; (b)
damage, destruction, or loss, not covered by insurance, that could reasonably be
expected to have a Company Material Adverse Effect; (c) material change by the
Company or any Subsidiary in accounting methods or principles used for financial
reporting purposes, except as required by a change in applicable law or
generally accepted accounting principles and concurred with by the Company's
independent public accountants; or (d) agreement, whether in writing or
otherwise, to take any action described or referenced in this Section 3.9. To
the knowledge of the Company, between June 30, 1998 and the date of this
Agreement, there have been no events, occurrences or developments with respect
to the business or assets of World Medical that could, assuming the Company's
acquisition of World Medical, reasonably be expected to have a Company Material
Adverse Effect.
 
    3.10  OFFICERS, DIRECTORS AND EMPLOYEES.  Prior to the date hereof, the
Company has provided to Parent a list that completely and accurately sets forth,
as of the date hereof, the name and current annual salary rate of each current
officer of the Company whose total remuneration for the last fiscal year was, or
for the current fiscal year has been set at, in excess of $150,000, together
with a summary of the bonuses, commissions, additional compensation, and other
like cash benefits, if any, paid or payable to such persons for the last fiscal
year and proposed for the current fiscal year. The Company Disclosure Schedule
completely and accurately sets forth (i) the names of all former officers of the
Company whose employment with the Company has terminated either voluntarily or
involuntarily during the 12-month period preceding the date of this Agreement;
and (ii) the names of the officers (with all positions and titles indicated) and
directors of the Company as of the date hereof. Except as could not reasonably
be expected to have a Company Material Adverse Effect: (i) no unfair labor
practice complaint against the Company or any Subsidiary is pending before the
National Labor Relations Board, and there is no labor strike, slowdown or
stoppage pending or, to the knowledge of the Company, threatened in writing
against or involving the Company or any Subsidiary; (ii) no unionizing efforts
have, to the knowledge of the Company, been made by employees of the Company or
any Subsidiary, (iii) neither the Company nor any Subsidiary is a party to or
subject to any collective bargaining agreement, and no collective bargaining
agreement is currently being negotiated by the Company or any Subsidiary; and
(iv) there is no labor dispute pending or, to the knowledge of the Company,
threatened in writing, between the Company or any Subsidiary and its employees.
 
    3.11  TAXES.  Except for such matters that would not have a Company Material
Adverse Effect, (i) the Company and each Subsidiary have filed, or have obtained
extensions to file (which extensions have not expired without filing), all
state, local, United States, foreign, or other tax reports and returns required
to be filed by any of them, (ii) the Company and each Subsidiary have duly paid,
or accrued on their books of account, all taxes (including estimated taxes)
shown as due on such reports and returns (or such extension requests), or
assessed against them, other than taxes being contested in good faith in proper
proceedings, and (iii) to the Company's knowledge, the liabilities and reserves
for taxes reflected on the Company Audited Balance Sheet or the Company Interim
Balance Sheet are adequate to cover all taxes payable by the Company and its
Subsidiaries for all taxable periods and portions thereof ending on or before
the dates thereof. To the Company's knowledge, no tax audits are pending against
and no claims for taxes have been received in writing by the Company or any of
its Subsidiaries, other than audits and claims that are not reasonably expected
to have a Company Material Adverse Effect. Neither the Company nor
 
                                      A-15
<PAGE>
any Subsidiary has, with regard to any assets or property held, acquired or to
be acquired by any of them, filed a consent to the application of Section
341(f)(2) of the Code. Neither the Company nor, to the knowledge of the Company,
any of its Subsidiaries has taken or agreed to take any action (other than
actions contemplated by this Agreement) that would prevent the Merger from
constituting a reorganization qualifying under Section 368(a) of the Code. The
Company is not aware of any agreement, plan or other circumstance that would
prevent the Merger from so qualifying under Section 368(a) of the Code.
 
    For the purposes of this Agreement, "tax" shall mean and include taxes,
duties, withholdings, assessments, and charges assessed or imposed by any
governmental authority (together with any interest, penalties and additions to
tax imposed with respect thereto), including but not limited to all federal,
state, county, local, and foreign income, profits, gross receipts, import, ad
valorem, real and personal property, franchise, license, sales, use, value
added, stamp, transfer, withholding, payroll, employment, excise, custom, duty,
and any other taxes, obligations and assessments of any kind whatsoever; "tax"
shall also include any liability for taxes arising as a result of being (or
ceasing to be) a member of any affiliated, consolidated, combined, or unitary
group as well as any liability for taxes under any tax allocation, tax sharing,
tax indemnity, or similar agreement.
 
    3.12  CONTRACTS.  The Company Disclosure Schedule lists, and the Company has
heretofore furnished to Parent complete and accurate copies of (or, if oral, the
Company Disclosure Schedule states all material provisions of), (a) every
employment, material consulting, severance or change of control agreement or
arrangement for the benefit of any director, officer, employee, other person or
stockholder of the Company or any Subsidiary or any affiliate thereof in effect
as of the date of this Agreement to which the Company or any Subsidiary is a
party or by which the Company or any Subsidiary or any of their properties or
assets is bound, and (b) every contract with physicians, scientific advisory
board members or material consultants in effect as of the date of this Agreement
to which the Company or any Subsidiary is a party or by which the Company or any
Subsidiary or any of their properties or assets is bound. Neither the Company
nor any Subsidiary is in material violation of or in default under any contract,
plan, agreement, understanding, arrangement or obligation that is material to
the Company and its Subsidiaries considered as a whole, except for such
violations or defaults that could not reasonably be expected to have a Company
Material Adverse Effect. As of the date of this Agreement, neither the Company
nor any Subsidiary is a party to any contract, plan, agreement, understanding,
arrangement or obligation (i) which materially restricts the Company's, or after
the Merger would materially restrict the Surviving Corporation's or Parent's,
ability to conduct any material line of business, (ii) which imposes on the
Company or any Subsidiary material obligations (including, without limitation,
to pay material milestone payments or material license fees) not reflected in
the Company's financial statements included within the Company's SEC Filings, or
(iii) that would be required to be filed with the SEC in a filing to which
paragraph (b)(10) of Item 601 of Regulation S-K of the Rules and Regulations of
the SEC is applicable, which has not been so filed. To the Company's knowledge,
as of the date hereof, World Medical is not a party to any contract, plan,
agreement, understanding, arrangement or obligation which materially restricts
World Medical's, or after the Merger would materially restrict the Surviving
Corporation's or Parent's, ability to conduct any material line of business.
 
    3.13  INTELLECTUAL PROPERTY RIGHTS.  For purposes of this Section,
"Intellectual Property" shall mean patents, registered trademarks, registered
trade names, registered service marks, registered copyrights, and all
applications for or registrations of any of the foregoing. As of the date of
this Agreement, the Company Disclosure Schedule contains a complete and accurate
list of all material Intellectual Property owned by or licensed exclusively or
(with respect to patents material to the products or operations of the Company
which would be infringed by the Company, any Subsidiary or their products but
for such license) non-exclusively to the Company or any Subsidiary (the "Company
Intellectual Property"). The Company Intellectual Property is owned by or
licensed to the Company or a Subsidiary free and clear of any Lien (as defined
in Section 3.3) that would materially adversely affect the Company's rights
thereunder. No claim is being asserted and, to the knowledge of the Company, no
person is threatening in a writing delivered to the Company to assert a claim,
with respect to the use of the Company Intellectual Property owned by the
 
                                      A-16
<PAGE>
Company or challenging or questioning the validity or effectiveness of any
license or agreement with respect to any Company Intellectual Property, except
for such claims that could not reasonably be expected to have a Company Material
Adverse Effect. To the knowledge of the Company, neither the use by the Company
or any Subsidiary of the Company Intellectual Property in the present conduct of
its business nor any product or service of the Company or any Subsidiary
infringes on the valid intellectual property rights of any person in a manner
that could reasonably be expected to have a Company Material Adverse Effect.
Except as could not reasonably be expected to have a Company Material Adverse
Effect, (i) all Company Intellectual Property listed in the Company Disclosure
Schedule that is owned by the Company has the status indicated therein and,
unless provided otherwise, all applications are still pending in good standing
and have not been abandoned, and (ii) to the knowledge of the Company, the
Company Intellectual Property is valid and is not being challenged in any
judicial or administrative (excluding any patent-office or registration)
proceeding. To the knowledge of the Company, no person or entity nor such
person's or entity's business or products has infringed, or misappropriated any
Company Intellectual Property, or currently is infringing, or misappropriating
any Company Intellectual Property, except as could not reasonably be expected to
have a Company Material Adverse Effect.
 
    3.14  BENEFIT PLANS.
 
        (a) Neither the Company nor any Subsidiary sponsors, maintains,
    contributes to, or has, during the five year period ending on the date of
    this Agreement, sponsored, maintained, or contributed to or been required to
    contribute to, any "employee pension benefit plan" ("Pension Plan"), as such
    term is defined in Section 3(2) of the Employee Retirement Income Security
    Act of 1974, as amended ("ERISA"), including, solely for the purpose of this
    subsection, a plan excluded from coverage by Section 4(b)(5) of ERISA. Each
    such Pension Plan presently maintained by the Company or any Subsidiary is,
    in all material respects, in compliance with applicable provisions of ERISA,
    the Code, and other applicable law and the Company or such Subsidiary has
    performed all of its obligations under such Pension Plan except for such
    obligations that could not reasonably be expected to have a Company Material
    Adverse Effect.
 
        (b) Neither the Company nor any Subsidiary sponsors, maintains,
    contributes to, or has, during the five year period ending on the date of
    this Agreement, sponsored, maintained, or contributed to or been required to
    contribute to, any Pension Plan that is subject to Title IV of ERISA.
 
        (c) Neither the Company nor any Subsidiary sponsors, maintains, or
    contributes to any "employee welfare benefit plan" ("Welfare Plan"), as such
    term is defined in Section 3(1) of ERISA, whether insured or otherwise, and
    any such Welfare Plan presently maintained by the Company or any Subsidiary
    is, in all material respects, in compliance with the provisions of ERISA,
    the Code, and all other applicable laws, including, but not limited to,
    Section 4980B of the Code and the regulations thereunder, and Part 6 of
    Title I of ERISA. Neither the Company nor any Subsidiary has established or
    contributed to any "voluntary employees' beneficiary association" within the
    meaning of Section 501(c)(9) of the Code.
 
        (d) Neither the Company nor any Subsidiary currently maintains or
    contributes to any oral or written bonus, profit-sharing, compensation
    (incentive or otherwise), commission, stock option, or other stock-based
    compensation, retirement, severance, change of control, vacation, sick or
    parental leave, dependent care, deferred compensation, cafeteria,
    disability, hospitalization, medical, death, retiree, insurance, or other
    benefit or welfare or other similar plan, policy, agreement, trust, fund, or
    arrangement providing for the remuneration or benefit of all or any
    employees, directors or any other person, that is neither a Pension Plan nor
    a Welfare Plan (collectively, the "Compensation Plans").
 
        (e) With respect to the Pension Plans, Welfare Plans or Compensation
    Plans, no event has occurred and, to the knowledge of the Company, there
    exists no condition or set of circumstances, in connection with which the
    Company or any of its Subsidiaries could be subject to any liability under
 
                                      A-17
<PAGE>
    the terms of such Plans (other than the payment of benefits thereunder),
    ERISA, the Code or any other applicable law which could reasonably be
    expected to have a Company Material Adverse Effect.
 
        (f) The Internal Revenue Service has issued favorable determination
    letters with respect to all Company and Subsidiary Pension Plans that are
    intended to be qualified under Section 401(a) of the Code. The Company has
    provided to Parent the written documents setting forth the terms of all
    Pension Plans, Welfare Plans, Compensation Plans, and related agreements,
    and complete and accurate copies of all annual reports (Form 5500),
    favorable determination letters, current summary plan descriptions, and all
    employee handbooks or manuals. The Company has provided to Parent (i) copies
    of all employment agreements with officers of any of the Company, its U.S.
    Subsidiaries or, to the extent reasonably available, the Company's non-U.S.
    Subsidiaries (or copies of forms of agreements setting forth representative
    employment terms and conditions); (ii) copies of all severance, bonus or
    incentive agreements, programs and policies of any of the Company, any U.S.
    Subsidiary or, to the extent reasonably available, the Company's non-U.S.
    Subsidiaries with or relating to any of its employees; and (iii) copies of
    all plans, programs, agreements and other arrangements of any of the
    Company, any U.S. Subsidiary or, to the extent reasonably available, the
    Company's non-U.S. Subsidiaries with or relating to any of its employees
    which contain change in control provisions. With respect to any items that
    would be described in the immediately preceding sentence but for the fact
    that such copies relate to non-U.S. Subsidiaries and are not reasonably
    available to the Company, the Company (i) shall deliver copies thereof to
    Parent prior to the Effective Time, and (ii) represents and warrants to
    Parent that such items will not, individually or in the aggregate, be
    material to the Company and its Subsidiaries.
 
        (g) The execution by the Company of, and performance by the Company of
    the transactions contemplated in, this Agreement will not (either alone or
    upon the occurrence of any additional or subsequent events) constitute an
    event under any Pension Plan, Welfare Plan, Compensation Plan, or other
    arrangement that will result in any payment (whether of severance pay or
    otherwise), acceleration, forgiveness of indebtedness, vesting,
    distribution, increase in benefits, or obligation to fund benefits. No
    amount that could be received (whether in cash or property or the vesting of
    property) as a result of any of the transactions contemplated by this
    Agreement by any employee, officer, or director of the Company or any of its
    affiliates who is a "disqualified individual" (as such term is defined in
    Prop. Treas. Reg. Section 1.280G-1) under any Pension Plan, Welfare Plan, or
    Compensation Plan currently in effect would be an "excess parachute payment"
    (as such term is defined in Section 280G(b)(1) of the Code).
 
    3.15  MINUTE BOOKS.  The Company has previously made available to Parent or
its representatives all of its minutes of meetings of and corporate actions or
written consents by the stockholders, Board of Directors, and committees of the
Board of Directors of the Company.
 
    3.16  NO FINDERS.  No act of the Company or any Subsidiary has given or will
give rise to any claim against any of the parties hereto for a brokerage
commission, finder's fee, or other like payment in connection with the
transactions contemplated herein, except payments in the amounts specified in
the Company Disclosure Schedule to those parties identified thereon who have
acted as a finder for the Company or have been retained by the Company as
financial advisors pursuant to the agreements or other documents described in
the Company Disclosure Schedule, copies of which have been provided or made
available to Parent or its advisors prior to the date of this Agreement.
 
    3.17  PROXY STATEMENT.  The Proxy Statement/Prospectus (as defined in
Section 5.5 hereof) and any amendments or supplements thereto will comply as to
form in all material respects with all applicable laws, and none of the
information supplied by the Company specifically for inclusion or incorporation
therein or in any amendments or supplements thereto, or in any schedules
required to be filed with the SEC in connection therewith, will, at the date the
Proxy Statement/Prospectus (or any amendment or supplement thereto) is first
mailed to stockholders, or at the time of the Company Stockholders' Meeting,
contain any
 
                                      A-18
<PAGE>
untrue statement of a material fact or omit to state any material fact required
to be stated therein or necessary in order to make the statements therein, in
light of the circumstances under which they were made, not misleading; provided,
however, that no representation or warranty is made by the Company with respect
to information relating to Parent or any affiliate of Parent supplied by Parent
specifically for inclusion in the Proxy Statement/Prospectus.
 
    3.18  FAIRNESS OPINION.  The Company has received an opinion from SG Cowen
Securities Corporation to the effect that, as of the date of such opinion, the
Conversion Ratio is fair, from a financial point of view, to the holders of
Company Common Stock, and the Company will promptly deliver a copy of such
opinion to Parent.
 
    3.19  STATE TAKEOVER LAWS; RIGHTS PLAN.
 
        (a) The Board of Directors of the Company has approved the transactions
    contemplated by this Agreement, such that the provisions of Section 203
    (entitled "Business Combinations with Interested Shareholders") of the DGCL
    will not apply to this Agreement or the Agreements to Facilitate Merger or
    the Stock Option Agreement or any of the transactions contemplated hereby or
    thereby.
 
        (b) The Company has taken all actions and completed all amendments, if
    any, necessary or appropriate so that (i) the Rights Agreement dated as of
    February 26, 1997, as amended, between the Company and BankBoston, N.A. (the
    "Company Rights Agreement"), is inapplicable to the transactions
    contemplated by the Agreements to Facilitate Merger, the Stock Option
    Agreement and this Agreement, (ii) the execution of this Agreement, the
    Stock Option Agreement, and the Agreements to Facilitate Merger, and the
    consummation of the transactions contemplated hereby and thereby, do not and
    will not (w) result in Parent being an "Acquiring Person" (as such term is
    defined in the Company Rights Agreement), (x) result in the ability of any
    person to exercise any Rights under the Company Rights Agreement, (y) enable
    or require the Rights to separate from the shares of Company Common Stock to
    which they are attached or to be triggered or become exercisable, or (z)
    otherwise result in the occurrence of a "Distribution Date" or "Shares
    Acquisition Date" (as such terms are defined in the Company Rights
    Agreement), and (iii) immediately prior to the Effective Time, the Rights
    under the Company Rights Agreement shall, without any payment by the Company
    or Parent, expire with neither the Company nor Parent having any obligations
    under, and no holder of Rights having any rights under, the Company Rights
    Agreement.
 
    3.20  MERGER FILINGS.  The information as to the Company or any of its
affiliates or stockholders included in the Company's filing, or submitted to
Parent and Merger Subsidiary for inclusion in their filing, if any, required to
be submitted under the HSR Act or under any Foreign Merger Laws shall be true,
correct, and complete in all material respects and shall comply in all material
respects with the applicable requirements of the HSR Act, the rules and
regulations issued by the Federal Trade Commission pursuant thereto, and Foreign
Merger Laws.
 
                                   ARTICLE 4
                         REPRESENTATIONS AND WARRANTIES
                        OF PARENT AND MERGER SUBSIDIARY
 
    Except (i) as set forth in a document of even date herewith and concurrently
delivered herewith (the "Parent Disclosure Schedule") or (ii) as specifically
described through express disclosure of current, specific facts set forth in
Parent's Annual Report on Form 10-K for the fiscal year ended April 30, 1998 or
in any other filing by Parent with the SEC filed after the date of filing such
Form 10-K and prior to the date hereof (for purposes of clauses (i) and (ii)
above, disclosures in the Parent Disclosure Schedule and such Parent SEC filings
shall be deemed to qualify or limit only those particular representations and
warranties set forth in this Article 4 to which the relevancy of such
disclosures is readily apparent), Parent and Merger Subsidiary hereby jointly
and severally make the following representations and warranties to the Company:
 
                                      A-19
<PAGE>
    4.1  ORGANIZATION.  Parent is a corporation duly organized, validly
existing, and in good standing under the laws of the State of Minnesota. Merger
Subsidiary is a corporation duly organized and validly existing under the laws
of the State of Delaware. Each of Parent and Merger Subsidiary has all requisite
corporate power and authority to own, lease, and operate its properties and to
carry on its business as now being conducted, except where the failure to be so
organized, existing or in good standing or to have such corporate power and
authority would not, individually or in the aggregate, have a Parent Material
Adverse Effect (as defined below). Each of Parent and Merger Subsidiary is duly
qualified and in good standing to do business in each jurisdiction in which the
property owned, leased, or operated by it or the nature of the business
conducted by it makes such qualification necessary, except where the failure to
be so qualified or in good standing could not reasonably be expected to have a
Parent Material Adverse Effect (as defined below). "Parent Material Adverse
Effect" means an effect that, in the aggregate with other favorable and
unfavorable effects arising from breaches of Parent's and Merger Subsidiary's
representations and warranties, is or would reasonably at the time of such
effect be expected to be materially adverse: (i) to the business, results of
operation, or financial condition of Parent and its subsidiaries, considered as
a whole, or (ii) to Parent's ability to perform any of its material obligations
under this Agreement or to consummate the Merger, except in each case for any
such effects resulting from or arising out of (i) this Agreement or the
transactions contemplated by this Agreement or the announcement or pendency of
the Merger, (ii) any occurrence or condition affecting the medical device
industry generally or affecting Parent's principal market sector generally, or
(iii) any changes in general economic, regulatory or political conditions.
Parent has heretofore delivered or made available to the Company or its advisors
complete and accurate copies of the Articles of Incorporation and Bylaws of
Parent, as currently in effect.
 
    4.2  AUTHORIZATION.  Each of Parent and Merger Subsidiary has all necessary
corporate power and authority to execute and deliver this Agreement and to
consummate the transactions contemplated hereby. The execution and delivery by
Parent and Merger Subsidiary of this Agreement and the other agreements
contemplated hereby to which Parent or Merger Subsidiary is a party, and the
consummation by Parent and Merger Subsidiary of the transactions contemplated
hereby and thereby, have been duly and validly authorized and approved by the
Boards of Directors of Parent and Merger Subsidiary and by Parent as the sole
shareholder of Merger Subsidiary, and no other corporate proceedings on the part
of Parent and Merger Subsidiary, and no vote, consent or approval of Parent's
shareholders, are necessary to authorize this Agreement or to consummate the
transactions contemplated hereby. The Merger has been declared advisable by the
Board of Directors of Merger Subsidiary. This Agreement has been duly and
validly executed and delivered by each of Parent and Merger Subsidiary and,
assuming due execution and delivery by the Company, constitutes the valid and
binding obligation of Parent and Merger Subsidiary, enforceable against each of
them in accordance with its terms, subject to laws of general application
relating to bankruptcy, insolvency, and the relief of debtors and rules of law
governing specific performance, injunctive relief, or other equitable remedies.
 
    4.3  CAPITALIZATION.  As of October 23, 1998, the authorized capital stock
of Parent consisted of (a) 800,000,000 shares of Common Stock with a par value
of $.10 per share, of which there were 489,262,955 shares issued and outstanding
and no shares held in Parent's treasury, and (b) 2,500,000 shares of Preferred
Stock with a par value of $1.00 per share, of which there were no shares issued
and outstanding. The authorized capital stock of Merger Subsidiary consists of
2,500 shares of Merger Subsidiary Common Stock, 100 of which are issued and
outstanding and owned by Parent. All issued and outstanding shares of Parent
Common Stock and Merger Subsidiary Common Stock are, and the shares of Parent
Common Stock to be issued and delivered in the Merger pursuant to Article 1
hereof shall be, at the time of issuance and delivery, validly issued, fully
paid, nonassessable, and free of preemptive rights. The shares of Parent Common
Stock to be issued and delivered in the Merger pursuant to Article 1 hereof
shall be registered under the 1933 Act and duly listed for trading on the NYSE,
subject to official notice of issuance.
 
                                      A-20
<PAGE>
    4.4  CONSENTS AND APPROVALS.  Except for (i) any applicable requirements of
the 1933 Act, the 1934 Act, state securities laws, the NYSE, the HSR Act, and
Foreign Merger Laws, and (ii) the filing and recordation of appropriate merger
documents as required by the DGCL, the execution and delivery by Parent and
Merger Subsidiary of this Agreement and the other agreements contemplated hereby
to which Parent and Merger Subsidiary are parties, and the consummation of the
transactions contemplated hereby and thereby will not: (a) violate any provision
of the Certificate or Articles of Incorporation or Bylaws of Parent or Merger
Subsidiary; (b) violate any material statute, rule, regulation, order, or decree
of any Governmental Body or any nongovernmental self-regulatory agency by which
Parent or any of its subsidiaries or any of their respective properties or
assets may be bound; (c) require any filing by Parent or Merger Subsidiary with
or permit, consent, or approval to be obtained by Parent or Merger Subsidiary
from any (Governmental Body or any nongovernmental self-regulatory agency; or
(d) result in any violation or breach of, or constitute (with or without due
notice or lapse of time or both) a default under, result in the loss of any
material benefit under, or give rise to any right of termination, cancellation,
increased payments, or acceleration under, or result in the creation of any Lien
on any of the properties or assets of Parent or its subsidiaries under, any of
the terms, conditions, or provisions of any note, bond, mortgage, indenture,
license, franchise, permit, agreement, or other instrument or obligation to
which Parent or any of its subsidiaries is a party, or by which any of them or
any of their respective properties or assets may be bound, except, in the case
of clauses (c) and (d), for any such filings, permits, consents or approvals or
violations, breaches, defaults, or other occurrences that could not reasonably
be expected to prevent or delay consummation of any of the transaction
contemplated hereby in any material respect, or otherwise prevent Parent from
performing its obligations under this Agreement in any material respect, and
could not reasonably be expected to have a Parent Material Adverse Effect.
 
    4.5  REPORTS; FINANCIAL STATEMENTS; ABSENCE OF CHANGES.  Parent has filed
all forms, reports, registration statements, and other documents required to be
filed by it with the SEC since May 1, 1995 (such forms, reports, registration
statements and other documents, together with any amendments thereto, are
referred to as the "Parent SEC Filings"). As of their respective dates, the
Parent SEC Filings (i) complied as to form in all material respects with the
applicable requirements of the 1933 Act and the 1934 Act, as the case may be,
and (ii) did not contain any untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements made therein, in light of the circumstances under which they were
made, not misleading. The audited financial statements included or incorporated
by reference in the Parent SEC Filings, including but not limited to Parent's
audited financial statements at and for the year ended April 30, 1998 (the
"Parent April 30, 1998 Financials"), and the unaudited interim financial
statements at and for periods commencing on or after May 1, 1998 included or
incorporated by reference in the forms, reports, registration statements and
other documents filed by Parent with the SEC (i) were prepared in accordance
with generally accepted accounting principles (except, in the case of unaudited
statements, as permitted by Form 10-Q filed with the SEC) applied on a
consistent basis during the periods involved (except as may be indicated therein
or in the notes thereto) subject, in the case of unaudited interim financial
statements, to the absence of notes and to year-end adjustments, (ii) complied
as of their respective dates in all material respects with applicable accounting
requirements and the published rules and regulations of the SEC with respect
thereto, and (iii) fairly present in all material respects the consolidated
financial position of Parent and its consolidated subsidiaries as of the dates
thereof and the consolidated income, cash flows, and changes in shareholders'
equity of Parent and its consolidated subsidiaries for the periods involved,
except as otherwise noted therein and subject, in the case of unaudited
statements, to normal year-end audit adjustments. The statements of operations
included in the audited or unaudited interim financial statements in the Parent
SEC Filings do not contain any items of special or nonrecurring income or any
other income not earned in the ordinary course of business required to be
disclosed separately in accordance with generally accepted accounting
principles, except as expressly specified in the applicable statement of
operations or notes thereto.
 
                                      A-21
<PAGE>
    4.6  REGISTRATION STATEMENT.  The Registration Statement (as defined in
Section 5.5 hereof) and any amendments or supplements thereto will comply as to
form in all material respects with the 1933 Act, and none of the information
supplied by Parent specifically for inclusion or incorporation therein or in any
amendments or supplements thereto, or in any schedules required to be filed with
the SEC in connection therewith, will, at the time the Registration Statement
becomes effective, at the date the Proxy Statement/ Prospectus (or any amendment
or supplement thereto) is first mailed to stockholders, or at the time of the
Company Stockholders' Meeting, or at the Effective Time, contain any untrue
statement of a material fact or omit to state any material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading, provided, however,
that no representation or warranty is made by Parent with respect to information
supplied by the Company or any affiliate of the Company specifically for
inclusion in the Registration Statement.
 
    4.7  NO FINDERS.  No act of Parent or Merger Subsidiary has given or will
give rise to any claim against any of the parties hereto for a brokerage
commission, finder's fee, or other like payment in connection with the
transactions contemplated herein, except for payments to Goldman Sachs & Co. for
financial advisory services to Parent in connection herewith.
 
    4.8  ABSENCE OF UNDISCLOSED LIABILITIES.  To the best of Parent's knowledge,
neither Parent nor any of its subsidiaries has any liabilities or obligations of
any nature (whether absolute, accrued, contingent or otherwise) of the type
required to be reflected on or reserved against in, or disclosed in the notes
to, a balance sheet prepared in accordance with U.S. generally accepted
accounting principles except: (a) liabilities or obligations that are accrued or
reserved against in the audited consolidated balance of Parent as of April 30,
1998 contained in the Parent SEC Filings or in the unaudited consolidated
balance sheet of Parent as of July 31, 1998 contained in Parent's Quarterly
Report on Form 10-Q for the fiscal quarter ended July 31, 1998 or referred to in
the notes thereto, (b) liabilities incurred in the ordinary course of business
since July 31, 1998 and (c) liabilities or obligations that could not reasonably
be expected to have a Parent Material Adverse Effect.
 
    4.9  COMPLIANCE WITH LAWS.  Neither Parent nor any of its subsidiaries is in
default or violation of any applicable federal, state, local or foreign laws,
ordinances, regulations, interpretations, judgments, decrees, injunctions,
permits, licenses, certificates, governmental requirements, orders or other
similar items of any court or other Governmental Body (and including those of
any nongovernmental self-regulatory agency and including environmental laws or
regulations), except for such defaults or violations that could not reasonably
be expected to have a Parent Material Adverse Effect. Parent and each of its
subsidiaries has timely filed or otherwise provided all registrations, reports,
data and other information and applications with respect to its Regulated
Products required to be filed with or otherwise provided to the FDA or any other
Governmental Body with jurisdiction over the manufacture, use of sale of the
Regulated Products, and all regulatory licenses or approvals in respect thereof
are in full force and effect, except where the failure to file timely such
registrations, reports, data, information and applications or the failure to
have such licenses and approvals in full force and effect could not reasonably
be expected to have a Parent Material Adverse Effect.
 
    4.10  LITIGATION.
 
        (a) As of the date of this Agreement, there is no Merger-Related
    Proceeding pending, or to the knowledge of Parent, threatened in writing
    against Parent.
 
        (b) There are no meritorious asserted claims, actions, suits,
    proceedings or to the knowledge of Parent, governmental investigations or
    governmental reviews of any kind pending, or to the knowledge of Parent,
    threatened in writing against Parent or any of its subsidiaries or any asset
    or property of Parent or any of its subsidiaries, other than Merger-Related
    Proceedings and except for such claims, actions, suits, proceedings,
    governmental investigations or governmental reviews that could not
    reasonably be expected to have a Parent Material Adverse Effect.
 
    4.11  ABSENCE OF MATERIAL ADVERSE CHANGES.  Between April 30, 1998 and the
date hereof, there has not been any (a) Parent Material Adverse Effect, (b)
damage, destruction or loss, not covered by
 
                                      A-22
<PAGE>
insurance, that could reasonably be expected to have a Parent Material Adverse
Effect, (c) material change by Parent or any of its subsidiaries in accounting
methods or principles used for financial reporting purposes, except as required
by a change in applicable law or generally accepted accounting principles and
concurred with by Parent's independent public accountants, or (d) agreement,
whether in writing or otherwise, to take any action described or referenced in
this Section 4.11. To the knowledge of Parent, between April 30, 1998 and the
date of this Agreement, there have been no events, occurrences or developments
with respect to the business or assets of either AVECOR Cardiovascular Inc. or
Sofamor Danek Group, Inc. that could, assuming Parent's acquisition of either
such entity, reasonably be expected to have a Parent Material Adverse Effect.
 
    4.12  REORGANIZATION.  Neither Parent nor, to the knowledge of Parent, any
of its subsidiaries has taken or agreed to take any action (other than actions
contemplated by this Agreement) that would prevent the Merger from constituting
a reorganization qualifying under Section 368(a) of the Code. Parent is not
aware of any agreement, plan or other circumstances that would prevent the
Merger from so qualifying under Section 368(a) of the Code.
 
    4.13  MERGER FILINGS.  The information as to Parent and Merger Subsidiary or
any of their affiliates or shareholders included in Parent's filing, or
submitted to the Company for inclusion in its filing, if any, required to be
submitted under the HSR Act or under any Foreign Merger Laws shall be true,
correct, and complete in all material respects and shall comply in all material
respects with the applicable requirements of the HSR Act, the rules and
regulations issued by the Federal Trade Commission pursuant thereto, and Foreign
Merger Laws.
 
                                   ARTICLE 5
                                   COVENANTS
 
    5.1  CONDUCT OF BUSINESS OF THE COMPANY.  Except as contemplated by this
Agreement or as set forth in Section 5.1 of the Company Disclosure Schedule,
unless Parent shall otherwise consent in writing (such consent not to be
unreasonably withheld or delayed), during the period from the date of this
Agreement to the Effective Time, the Company and each Subsidiary will, and the
Company shall use commercially reasonable efforts to cause to World Medical to,
(i) conduct its respective operations, to the extent commercially reasonable,
according to its ordinary and usual course of business and consistent with past
practice, and (ii) use commercially reasonable efforts to preserve substantially
intact its respective business organizations, to keep available the services of
its respective officers and employees and to maintain satisfactory relationships
with licensors, licensees, suppliers, contractors, distributors, physicians,
consultants, customers, and others having material business relationships with
it. The Company will promptly advise Parent of any material change in the
management, present or planned business, properties, liabilities, results of
operations, or financial condition of the Company or any material Subsidiary.
The Company will, prior to distributing or otherwise circulating any notices,
directives, or other communications directed to all or groups of customers,
vendors, employees, distributors, or others associated with its business
relating to the transactions contemplated hereby or to the operation of business
after consummation of such transactions, consult with Parent and give Parent
reasonable opportunity to comment thereon. Without limiting the generality of
the foregoing, and except as otherwise expressly provided in or contemplated by
this Agreement or as set forth in Section 5.1 of the Company Disclosure
Schedule, from the date of this Agreement until the Effective Time, neither the
Company nor any Subsidiary will, without the prior written consent of Parent
(such consent not to be unreasonably withheld or delayed):
 
        (a) amend its Certificate or Articles of Incorporation or, pursuant to
    action by the Company's Board of Directors, amend its Bylaws;
 
        (b) authorize for issuance, issue, sell, pledge, or deliver (whether
    through the issuance or granting of additional options, warrants,
    commitments, subscriptions, rights to purchase, or otherwise) any stock of
    any class or any securities convertible into shares of stock of any class
    (other than, so long as treatment of the Merger as a pooling of interests is
    not reasonably expected by Parent's or the
 
                                      A-23
<PAGE>
    Company's independent accounts to be jeopardized, the (i) issuance of shares
    of Company Common Stock pursuant to the exercise of stock options
    outstanding on the date of this Agreement or granted in accordance with this
    subsection (b), (ii) the issuance, in the ordinary course of business and
    consistent with past practice, of stock options to purchase, at not less
    than the fair market value on the date of grant, up to the number of shares
    specified in Section 5.1 of the Company Disclosure Schedule, and (iii)
    subject to the limitations set forth in Section 1.7(c), grant of purchase
    rights pursuant to the Company ESPP or the issuance of shares upon exercise
    of such purchase rights);
 
        (c) split, combine, or reclassify any shares of its capital stock,
    declare, set aside, or pay any dividend or other distribution (whether in
    cash, stock, or property or any combination thereof) in respect of its
    capital stock; or redeem or otherwise acquire any shares of its capital
    stock or its other securities (other than, so long as treatment of the
    Merger as a pooling of interests is not jeopardized, pursuant to contractual
    agreements with employees, directors or consultants existing as of the date
    of this Agreement); or amend or alter any material term of any of its
    outstanding securities;
 
        (d) other than indebtedness incurred in the ordinary course of business
    and consistent with past practice and other than intercompany indebtedness,
    create, incur or assume any indebtedness for borrowed money, or assume,
    guarantee, endorse, or otherwise agree to become liable or responsible for
    the obligations of any other person, or make any loans, advances or capital
    contributions to, or investments in, any other person; or create, incur or
    assume any Lien on any material asset other than any Lien that would not
    materially adversely affect the Company's or any Subsidiary's rights with
    respect thereto;
 
        (e) (i) increase in any manner the compensation of any of its directors,
    officers, employees, or consultants, or accelerate the payment of any such
    compensation, except in each case in the ordinary course of business and
    consistent with past practice (including, without limitation, annual year
    end increases and accelerated payments customarily made upon termination of
    employment) or consistent with existing contractual commitments or as
    required by applicable law; (ii) pay or accelerate or otherwise modify in
    any material respect the payment, vesting, exercisability, or other feature
    or requirement of any pension, retirement allowance, severance, change of
    control, stock option, or other employee benefit to any of its directors,
    officers, employees or consultants except as required by any existing plan,
    agreement, or arrangement; or (iii) except for normal increases in the
    ordinary course of business in accordance with its customary past practices
    or consistent with existing contractual commitments or as required by
    applicable laws, commit itself to any additional or increased pension,
    profit-sharing, bonus, incentive, deferred compensation, group insurance,
    severance, change of control, retirement or other benefit, plan, agreement,
    or arrangement, or to any employment or consulting agreement, with or for
    the benefit of any person, or amend any of such plans or any of such
    agreements in existence on the date hereof (except any amendment required by
    law or that would not materially increase benefits under the relevant plan);
 
        (f) except in the ordinary course of business and consistent with past
    practice or pursuant to contractual obligations existing on the date hereof,
    sell, transfer, mortgage, or otherwise dispose of or encumber any assets or
    properties material to the Company and its Subsidiaries, considered as a
    whole other than any Lien that would not materially adversely affect the
    Company's and its Subsidiaries' rights with respect to such assets or
    properties;
 
        (g) acquire or agree to acquire (i) by merging or consolidating with, or
    by purchasing a substantial portion of the assets of, or by any other
    manner, any business of any corporation, partnership, joint venture,
    association, or other business organization or division thereof or (ii) any
    assets that are material, individually or in the aggregate, to the Company
    and its Subsidiaries, considered as a whole, except as provided in
    subsection (h) below and except purchases of inventory in the ordinary
    course of business consistent with past practice;
 
        (h) make or agree to make any new capital expenditure or expenditures,
    except for up to $30,000,000 of capital expenditures pursuant to the
    Company's budget previously provided to Parent;
 
                                      A-24
<PAGE>
        (i) enter into, amend in any material respect, or terminate any joint
    ventures or any other agreements, commitments, or contracts that are
    material to the Company and its Subsidiaries, considered as a whole (except
    agreements, commitments, or contracts expressly provided for or contemplated
    by this Agreement or for the purchase, sale, or lease of goods, services, or
    properties in the ordinary course of business, consistent with past
    practice);
 
        (j) enter into or terminate, or amend, extend, renew, or otherwise
    modify in any material respect (including, but not limited to, by default or
    by failure to act) any material distribution, OEM, independent sales
    representative, noncompetition, licensing, franchise, research and
    development, supply, or similar contract, agreement, or understanding
    (except agreements, commitments, or contracts expressly provided for or
    contemplated by this Agreement or for the purchase, sale, or lease of goods,
    services, or properties in the ordinary course of business, consistent with
    past practice), or enter into any contract, plan, agreement, understanding,
    arrangement or obligation which materially restricts the Company's, or after
    the Merger would restrict the Surviving Corporation's or Parent's, ability
    to conduct any material line of business;
 
        (k) change in any material respect its credit policy as to sales of
    inventories or collection of receivables or its inventory consignment
    practices;
 
        (l) remove or permit to be removed from any building, facility, or real
    property any material machinery, equipment, fixture, vehicle, or other
    personal property or parts thereof, except in the ordinary course of
    business or unless the same is replaced with similar items of equal quality;
 
        (m) alter or revise its accounting principles, procedures, methods, or
    practices in any material respect, except as required by applicable law or
    by a change in generally accepted accounting principles and concurred with
    by the Company's independent public accountants;
 
        (n) institute, settle, or compromise any claim, action, suit, or
    proceeding pending or threatened by or against it involving amounts in
    excess of $1,000,000, at law or in equity or before any Governmental Body
    (including, but not limited to, the FDA) or any nongovernmental
    self-regulatory agency;
 
        (o) knowingly take any action that would render any representation,
    warranty, covenant, or agreement of the Company in this Agreement inaccurate
    or breached such that the conditions in Section 6.2 will not be satisfied as
    of the Closing Date;
 
        (p) fail to use commercially reasonable efforts to cause World Medical
    to refrain from taking any actions described in subsections (d), (e), (f),
    (g), (i), (j), (k), (l), (m), (n), or (o) above; or
 
        (q) agree, whether in writing or otherwise, to do any of the foregoing.
 
    5.2  CONDUCT OF BUSINESS OF PARENT.  Except as contemplated by this
Agreement, from the date of this Agreement until the Effective Time, Parent will
not do, and will not permit any of its subsidiaries to do, any of the following
without the prior written consent of the Company (such consent not to be
unreasonably withheld or delayed):
 
        (a) combine or reclassify any shares of its capital stock, declare, set
    aside or pay any extraordinary dividend or other distribution (whether in
    cash, stock or property or any combination thereof, but excluding a stock
    split effected in the form of a stock dividend) in respect of its capital
    stock, or redeem or otherwise acquire (other than pursuant to Parent's
    previously established stock repurchase program or as would not violate
    Section 5.21) any shares of its capital stock or amend or alter any material
    term of any of its outstanding securities;
 
        (b) acquire or agree to acquire, by merging or consolidating with, or by
    purchasing a substantial portion of the assets of, or by any other manner,
    any business of any corporation, partnership, joint venture, association or
    other business organization or division thereof, or otherwise acquire or
    agree to acquire, or dispose of or agree to dispose of, any assets of any
    person, which, in each case, could
 
                                      A-25
<PAGE>
    reasonably be expected to delay materially the consummation of, or increase
    materially the risk of non-consummation of, the transactions contemplated by
    this Agreement;
 
        (c) alter or revise its accounting principles, procedures, methods or
    practices in any material respect, except as required by applicable law or
    regulation or by a change in generally accepted accounting principles and
    concurred with by Parent's independent public accountants;
 
        (d) knowingly take any action that would result in a failure to maintain
    the trading of Parent Common Stock on the NYSE;
 
        (e) knowingly take any action, or knowingly fail to take any action,
    that would render any representation, warranty, covenant or agreement of
    Parent in this Agreement inaccurate or breached such that the conditions in
    Section 6.3 will not be satisfied; or
 
        (f) fail to use commercially reasonable efforts to cause AVECOR
    Cardiovascular Inc. and Sofamor Danek Group, Inc. to refrain from taking any
    actions described in subsection (e) above; or
 
        (g) agree, whether in writing or otherwise, to do any of the foregoing.
 
    5.3  NO SOLICITATION.  The Company and its Subsidiaries shall not, and shall
cause their respective officers, directors, employees, representatives, agents,
or affiliates (including, but not limited to any investment banker, attorney, or
accountant retained by the Company or any Subsidiary), not to, directly or
indirectly, solicit, knowingly encourage, initiate, or participate in any way in
discussions or negotiations with, or knowingly provide any nonpublic information
to, any corporation, partnership, person, or other entity or group (other than
Parent or any affiliate or agent of Parent) concerning any proposed Alternative
Transaction, or otherwise knowingly facilitate any effort or attempt to make or
implement an Alternative Transaction. For purposes of this Agreement,
"Alternative Transaction" shall mean any of the following involving the Company
or any Subsidiary: (i) any tender offer, exchange offer, merger, consolidation,
share exchange, business combination or similar transaction; (ii) any
transaction or series of related transactions pursuant to which any person or
entity (or its shareholders), other than Parent, or Merger Subsidiary or any of
their affiliates (a "Third Party") acquires shares (or securities exercisable
for or convertible into shares) representing more than 20% of the outstanding
shares of any class of capital stock of the Company or any Subsidiary; or (iii)
any sale, lease, exchange, licensing, transfer or other disposition pursuant to
which a Third Party acquires control of more than 20% of the assets (including,
but not limited to, intellectual property assets) of the Company and its
Subsidiaries taken as a whole (determined by reference to the fair market value
of such assets), in a single transaction or series of related transactions;
provided, however, that the proposed transaction with World Medical shall not
constitute an Alternative Transaction. The Company will immediately terminate
all discussions with Third Parties concerning any proposed Alternative
Transaction, and will request that such Third Parties promptly return any
confidential information furnished by the Company in connection with any
proposed Alternative Transaction. The Company will not waive any provision of
any confidentiality, standstill or similar agreement entered into with any third
party regarding any proposed Alternative Transaction, and prior to the Closing
shall enforce all such agreements in accordance with their terms. The Company
will promptly communicate to Parent the name of the person or entity submitting,
and the terms and conditions of, any proposal or inquiry that it receives after
the date hereof in respect of any proposed Alternative Transaction or a
reasonably detailed description of any such information requested from it after
the date hereof or of any such negotiations or discussions being sought to be
initiated or continued with the Company after the date hereof in respect of a
proposed Alternative Transaction; provided, however, that this Agreement shall
not prohibit the Board of Directors of the Company from (i) prior to the
Required Company Stockholder Vote, furnishing nonpublic information to or
entering into discussions or negotiations with, any person or entity that makes
an unsolicited Superior Proposal (as defined below), if, and only to the extent
that, (a) such action is so required under applicable law in order for the Board
of Directors to comply with its applicable fiduciary duties to its stockholders
imposed by law, (b) prior to first furnishing nonpublic information to, or first
entering into substantive discussions and negotiations with, such person or
entity after the date hereof, the Company (I) (x) releases Parent from the
two-year standstill provisions of the Confidentiality Agreement
 
                                      A-26
<PAGE>
with respect to any proposal submitted by Parent to the Company's Board of
Directors for a transaction that, by the proposal's terms, would only be
consummated with the cooperation and approval of the Company's Board of
Directors (which proposal shall be submitted by Parent on a confidential basis
unless the Company or such person or entity proposing the Superior Proposal
publicly discloses the Superior Proposal), and (y) provides written notice to
Parent to the effect that it intends to furnish information to, or enter into
discussions or negotiations with, such person or entity, and naming and
identifying the person or entity making the Superior Proposal, and (II) receives
from such person or entity an executed confidentiality and standstill agreement
with terms no less favorable to the Company than the Confidentiality Agreement
entered into with Parent, as modified by clause (I)(x) of this sentence, and (c)
the Company provides Parent with all non-public information to be provided to
such person or entity which Parent has not previously received from the Company,
and the Company keeps Parent informed, on a daily or more regular basis if the
context requires or Parent so requests, of the status, terms and conditions and
all other material information with respect to any such discussions or
negotiations; and (ii) to the extent applicable, complying with Rule 14e-2 or
14d-9 promulgated under the 1934 Act with regard to a proposed Alternative
Transaction. Nothing in this section shall (x) permit the Company to terminate
this Agreement (except as specifically provided in Article 7 hereof), or (y)
permit the Company to enter into any agreement providing for an Alternative
Transaction (other than the confidentiality and standstill agreement as
provided, and in the circumstances and under the conditions set forth, above)
for as long as this Agreement remains in effect. For purposes of this Agreement,
a "Superior Proposal" shall mean a proposal for an Alternative Transaction that
the Board of Directors of the Company has reasonably and in good faith
determined (with the advice of its financial advisors and taking into account
all legal, financial and regulatory aspects of the likelihood of the
consummation of such Alternative Transaction, including, but not limited to, the
conditions to consummation and the consequences under such Alternative
Transaction proposal of any material adverse effects or changes in the Company)
to be more favorable to the Company's stockholders than the transactions
contemplated by this Agreement.
 
    5.4  ACCESS AND INFORMATION.
 
        (a) Except as required pursuant to any confidentiality agreement or
    similar agreement or arrangement to which the Company or any of its
    Subsidiaries is a party (in which case the Company shall use commercially
    reasonable efforts to provide acceptable alternative arrangements, not in
    violation of such agreement or arrangement, for disclosure to Parent or its
    advisors) or pursuant to applicable law, the Company shall afford to Parent,
    and to Parent's accountants, officers, directors, employees, counsel, and
    other representatives, reasonable access during normal business hours upon
    reasonable prior notice, from the date hereof through the Effective Time, to
    all of its properties, books, contracts, commitments, and records, and,
    during such period, the Company shall furnish promptly to Parent all
    information concerning the Company's and its Subsidiaries' businesses,
    prospects, properties, liabilities, results of operations, financial
    condition, testing, clinical trials, officers, employees, investigators,
    distributors, customers, suppliers, and others having material dealings with
    the Company as Parent may reasonably request and reasonable opportunity to
    contact and obtain information from such officers, employees, investigators,
    distributors, customers, suppliers, and others having dealings with the
    Company as Parent may reasonably request. During the period from the date
    hereof to the Effective Time, the parties shall in good faith meet and
    correspond on a regular basis for mutual consultation concerning the conduct
    of the Company's and the Subsidiaries' businesses and, in connection
    therewith, Parent shall be entitled, during normal business hours upon
    reasonable prior notice and in a manner that does not unreasonably interfere
    with the Company's business, to have employees or other representatives
    present at the offices of the Company and its Subsidiaries to observe, and
    be kept informed concerning, the Company's and the Subsidiaries' operations
    and business planning.
 
        (b) Parent shall hold in confidence all such nonpublic information as
    required by and in accordance with the confidentiality agreement dated
    November 13, 1998, between Parent and the Company (the "Confidentiality
    Agreement").
 
                                      A-27
<PAGE>
    5.5  APPROVAL OF STOCKHOLDERS; PROXY STATEMENT; REGISTRATION STATEMENT.
 
        (a) The Company shall promptly take all action necessary in accordance
    with the DGCL and the Company's Certificate of Incorporation and Bylaws to
    cause a special meeting of the Company's stockholders (the "Company
    Stockholders Meeting") to be duly called and held as soon as reasonably
    practicable following the date upon which the Registration Statement (as
    defined below) becomes effective for the purpose of voting upon the Merger
    and the adoption and approval of this Agreement and at such Meeting to
    submit this Agreement and the Merger to a vote of the stockholders. The
    stockholder vote or consent required for adoption and approval of this
    Agreement and the approval of the Merger shall be no greater than that set
    forth in the DGCL and the Company's Certificate of Incorporation as
    previously provided to Parent. Accordingly, the Company represents and
    warrants that the affirmative vote of the holders of record of a majority of
    the shares of Company Common Stock outstanding on the record date for the
    Company Stockholders Meeting is all that is necessary to obtain stockholder
    adoption and approval of this Agreement and approval of the Merger. The
    Company shall use best efforts to obtain the adoption and approval by the
    Company's stockholders of this Agreement and the approval by the Company's
    stockholders of the Merger, unless otherwise required under applicable law
    in order for the Board of Directors to comply with its applicable fiduciary
    duties to its stockholders imposed by law. In accordance therewith, the
    Company shall, with the cooperation of Parent, prepare and file, as soon as
    reasonably practicable, a proxy statement/ prospectus included as part of
    the Registration Statement (such proxy statement/prospectus, together with
    notice of meeting, form of proxy, and any letter or other materials to the
    Company's stockholders included therein are referred to in this Agreement as
    the "Proxy Statement/Prospectus"). Parent shall furnish to the Company all
    information concerning Parent and its subsidiaries, officers, directors and
    shareholders, and shall take such other action and otherwise cooperate, as
    the Company may reasonably request in connection with any such action. The
    Company shall use best efforts to cause the definitive Proxy
    Statement/Prospectus to be mailed to the stockholders of the Company, as
    soon as reasonably practicable after the Registration Statement shall have
    become effective, with the date of mailing as mutually determined by the
    Company and Parent. The Proxy Statement/Prospectus shall include the
    recommendation of the Company's Board of Directors in favor of the Merger,
    unless otherwise required under applicable law in order for the Board of
    Directors to comply with its applicable fiduciary duties to its stockholders
    imposed by law. Unless and until this Agreement is validly terminated
    pursuant to Article 7, nothing herein shall limit or eliminate in any way
    the Company's obligation to call, give notice of, convene and hold the
    Company Stockholders Meeting and at such meeting submit this Agreement and
    the Merger to a vote of the Company's stockholders (and not postpone or
    adjourn such meeting or the vote by the Company's stockholders upon this
    Agreement and the Merger to another date without Parent's approval, not to
    be unreasonably withheld if and only to the extent such postponement or
    adjournment is required by law or by SEC or Nasdaq regulation).
 
        (b) Parent shall, with the cooperation of the Company, prepare and file,
    as soon as reasonably practicable, a registration statement under the 1933
    Act registering the shares of Parent Common Stock to be issued in the Merger
    (the "Registration Statement"), which Registration Statement shall include
    the Proxy Statement/Prospectus. Parent will use commercially reasonable
    efforts to have the Registration Statement declared effective by the SEC as
    promptly thereafter as practicable. Parent shall also take any action
    required to be taken under state blue sky or securities laws in connection
    with the issuance of Parent Common Stock pursuant to the Merger. The Company
    shall furnish to Parent all information concerning the Company and its
    Subsidiaries and the holders of its capital stock, and shall take such other
    action and otherwise cooperate, as Parent may reasonably request in
    connection with any such action.
 
        (c) Parent shall notify the Company promptly (i) of the receipt of the
    comments of the SEC, (ii) of any request by the SEC for amendments or
    supplements to the Registration Statement, (iii) of the time when the
    Registration Statement has become effective or any supplement or amendment
    has
 
                                      A-28
<PAGE>
    been filed, or the issuance of any stop order and (iv) of the suspension of
    the qualification of the Parent Common Stock issuable in connection with the
    Merger for offering or sale in any jurisdiction and shall supply the Company
    with copies of all correspondence with the SEC with respect to the
    Registration Statement.
 
        (d) If at any time prior to the Effective Time, any event or
    circumstance relating to the Company, any Subsidiary, or the Company's
    officers or directors should occur and be discovered by the Company that is
    required to be described in an amendment or supplement to the definitive
    Proxy Statement/Prospectus or the Registration Statement, the Company shall
    promptly inform Parent. If at any time prior to the Effective Time, any
    event or circumstance relating to Parent or any of its subsidiaries or their
    respective officers or directors should occur and be discovered by Parent
    that is required to be described in an amendment or supplement to the
    definitive Proxy Statement/ Prospectus or the Registration Statement, Parent
    shall promptly inform the Company. Whenever any event occurs that should be
    described in an amendment of, or supplement to, the definitive Proxy
    Statement/Prospectus or the Registration Statement, the Company or Parent,
    as the case may be, shall, upon learning of such event, promptly notify the
    other and consult and cooperate with the other in connection with the
    preparation of a mutually acceptable amendment or supplement. The parties
    shall promptly file such amendment or supplement with the SEC and mail such
    amendment or supplement as soon as practicable after it is cleared by the
    SEC. No amendment or supplement to the Proxy Statement/Prospectus or the
    Registration Statement will be made by Parent or the Company without the
    approval of the other party (such approval not to be unreasonably withheld
    or delayed).
 
    5.6  CONSENTS.  The Company will, at its cost and expense, use commercially
reasonable efforts to obtain all material approvals and consents of all third
parties necessary on the part of the Company or its Subsidiaries to consummate
the transactions contemplated hereby. Parent agrees to cooperate with the
Company in connection with obtaining such approvals and consents. Parent will,
at its cost and expense, use commercially reasonable efforts to obtain all
material approvals and consents of all third parties necessary on the part of
Parent to consummate the transactions contemplated hereby. The Company and
Parent agree to cooperate with each other in connection with obtaining such
approvals and consents.
 
    5.7  AFFILIATES' LETTERS.
 
        (a) The Company has delivered to Parent a list of names and addresses of
    those persons, in the Company's reasonable judgment after consultation with
    outside legal counsel, who, as of the date hereof, are affiliates within the
    meaning of Rule 145 of the rules and regulations promulgated under the 1933
    Act or otherwise applicable SEC accounting releases with respect to
    pooling-of-interests accounting treatment (each such person, an "Affiliate")
    of the Company. The Company shall provide Parent such information and
    documents as Parent shall reasonably request for purposes of reviewing such
    list and shall promptly update such list to reflect any changes thereto. The
    Company has delivered or caused to be delivered, or will, promptly after the
    execution hereof, deliver or cause to be delivered, to Parent an affiliate's
    letter in the form attached hereto as EXHIBIT B, executed by each of the
    Affiliates of the Company identified in the foregoing list, who were
    available, and shall use reasonable best efforts to deliver or cause to be
    delivered to Parent as soon as practicable after the date hereof such an
    affiliate's letter executed by any Affiliate who was not available to sign
    and deliver such letter on or prior to the date hereof and by any additional
    persons who, to the knowledge of the Company, become Affiliates after the
    date hereof. Parent shall be entitled to place legends as specified in such
    affiliates' letters on the certificates evidencing any of the Parent Common
    Stock received by such Affiliates pursuant to the terms of this Agreement,
    and to issue appropriate stop transfer instructions to the transfer agent
    for the Parent Common Stock, consistent with the terms of such letters.
 
        (b) For so long as resales of shares of Parent Common Stock issued
    pursuant to the Merger are subject to the resale restrictions set forth in
    Rule 145 under the 1933 Act, Parent will use commercially reasonable efforts
    to comply with Rule 144(c)(1) under the 1933 Act.
 
                                      A-29
<PAGE>
    5.8  EXPENSES.  Whether or not the Merger is consummated, all costs and
expenses incurred in connection with this Agreement, the transactions
contemplated hereby, the Proxy Statement/Prospectus, and the Registration
Statement will be paid by the party incurring such costs and expenses, except
that the Company and Parent will share equally the cost of printing and filing
with the SEC the Proxy Statement/ Prospectus and the Registration Statement and
the filing fees required under the HSR Act or any Foreign Merger Laws.
 
    5.9  FURTHER ACTIONS.  Subject to the terms and conditions herein provided
and without being required to waive any conditions herein (whether absolute,
discretionary, or otherwise), each of the parties hereto agrees to use
commercially reasonable efforts to take, or cause to be taken, all action, and
to do, or cause to be done, all things necessary, proper, or advisable to
consummate and make effective the transactions contemplated by this Agreement.
In case at any time after the Effective Time any further action is necessary or
desirable to carry out the purposes of this Agreement, the proper officers and
directors of each party to this Agreement shall take all such necessary action.
 
    5.10  REGULATORY APPROVALS.
 
        (a) The Company and Parent each agree to use commercially reasonable
    efforts to take, or cause to be taken, all appropriate action, and do, or
    cause to be done, all things as may be necessary under federal or state
    securities laws or the HSR Act or Foreign Merger Laws applicable to or
    necessary for, and will file as soon as reasonably practicable and, if
    appropriate, use commercially reasonable efforts to have declared effective
    or approved all documents and notifications with the SEC and other
    governmental or regulatory bodies (including, without limitation, the FDA
    and equivalent foreign regulatory bodies, and other foreign regulatory
    bodies that administer Foreign Merger Laws, and any foreign labor councils
    or bodies as may be required) that they deem necessary or appropriate for,
    the consummation of the Merger or any of the other transactions contemplated
    hereby, and each party shall give the other information reasonably requested
    by such other party pertaining to it and its subsidiaries and affiliates to
    enable such other party to take such actions.
 
        (b) Although the parties do not anticipate any legislative,
    administrative or judicial objection to the consummation of the Merger or
    any of the transactions contemplated by this Agreement, each of the Company,
    Parent and Merger Subsidiary agrees to use commercially reasonable efforts
    vigorously to contest and resist any action, including legislative,
    administrative or judicial action, and to have vacated, lifted, reversed or
    overturned any decree, judgment, injunction or other order (whether
    temporary, preliminary or permanent) (an "Order") that is in effect and that
    restricts, prevents or prohibits the consummation of the Merger or any of
    the other transactions contemplated by this Agreement, including, without
    limitation, by vigorously pursuing available avenues of administrative and
    judicial appeal. Each of the Company, Parent and Merger Subsidiary also
    agrees to use commercially reasonable efforts to take any and all actions
    necessary to avoid or eliminate each and every impediment under any
    antitrust law that may be asserted by any governmental antitrust authority
    or any other party so as to enable the parties to close by the date
    specified in Section 7.1(b) the transactions contemplated hereby, including
    without limitation, committing to and/or effecting, by consent decree, hold
    separate orders, or otherwise, the sale or disposition of such assets or
    businesses as are required to be divested in order to avoid the entry of, or
    to effect the dissolution of, any injunction, temporary restraining order or
    other order in any suit or proceeding, which would otherwise have the effect
    of preventing the consummation by the date specified in Section 7.1(b) of
    all or any material part of the transactions contemplated hereby.
    Notwithstanding the foregoing or anything herein to the contrary, in no
    event shall any party hereto be required under this Section 5.10 to make
    arrangements for or to effect the sale, cessation, or other disposition of
    product lines or businesses or take any action materially adverse to such
    party.
 
    5.11  CERTAIN NOTIFICATIONS.  The Company shall promptly notify Parent in
writing of the occurrence of any event that will or could reasonably be expected
to result in the failure by the Company or its affiliates to satisfy any of the
conditions specified in Section 6.1 or 6.2. Parent shall promptly notify the
 
                                      A-30
<PAGE>
Company in writing of the occurrence of any event that will or could reasonably
be expected to result in the failure by Parent or its affiliates to satisfy any
of the conditions specified in Section 6.1, 6.2(e) or 6.3.
 
    5.12  VOTING OF SHARES.  To induce Parent to execute this Agreement, certain
executive officers and directors of the Company included in the list of
"Affiliates" referenced in Section 5.7 have executed and delivered as of the
date hereof Agreements to Facilitate Merger in the form attached hereto as
EXHIBIT C (the "Agreement to Facilitate Merger"), pursuant to which each such
person has agreed to vote his or her shares of Company Common Stock in favor of
the Merger at the Company Stockholders Meeting. The Company will use reasonable
best efforts to have all other such Affiliates execute and deliver to Parent
Agreements to Facilitate Merger as soon as practicable after the date hereof.
 
    5.13  STOCK OPTION AGREEMENT.  To induce Parent to execute this Agreement,
the Company has executed and delivered to Parent as of the date hereof a Stock
Option Agreement in the form attached hereto as EXHIBIT D (the "Stock Option
Agreement"), pursuant to which the Company has granted to Parent an option to
acquire from the Company 12,807,795 shares of Company Common Stock at an
exercise price equal to $54.00 per share. Such option shall become exercisable
only in the events described in the Stock Option Agreement.
 
    5.14  NYSE LISTING APPLICATION.  Parent shall promptly prepare and submit to
the NYSE a listing application for the Parent Common Stock to be issued in the
Merger pursuant to Article 1 of this Agreement and pursuant to the Company
Options assumed by Parent, and shall use commercially reasonable efforts to
obtain, prior to the Effective Time, approval for the listing of such Parent
Common Stock, subject to official notice to the NYSE of issuance. The Company
shall cooperate with Parent in such listing application.
 
    5.15  INDEMNIFICATION.
 
        (a) The certificate of incorporation and the bylaws of the Surviving
    Corporation shall contain the provisions with respect to indemnification,
    payment of fees and expenses and exculpation from liability set forth in the
    Company's certificate of incorporation and bylaws on the date of this
    Agreement, which provisions shall not be amended, repealed or otherwise
    modified for a period of six years from the Effective Time in any manner
    that would adversely affect the rights thereunder of individuals who on or
    at any time prior to the Effective Time were directors, officers, employees
    or agents of the Company (the "Indemnified Parties"), unless such
    modification is required by law. From and after the Effective Time, Parent
    will cause the Surviving Corporation to fulfill and honor in all respects
    the obligations of the Company pursuant to each indemnification agreement in
    effect between the Company and an Indemnified Party. Parent shall guarantee
    the obligations of the Surviving Corporation with respect to the
    indemnification and payment of fees and expenses provisions contained in the
    Surviving Corporation's certificate of incorporation and bylaws and in the
    indemnification agreements described in the Company Disclosure Schedule in
    effect between the Company and an Indemnified Party as of the Effective Time
    with respect to acts occurring at or before the Effective Time (including
    the transactions contemplated by this Agreement).
 
        (b) For a period of six years after the Effective Time, Parent shall
    cause to be maintained in effect the Company's current directors' and
    officers' liability insurance policy with respect to claims arising from
    facts or events that occurred at or prior to the Effective Time; provided,
    however, that (i) Parent may substitute therefor policies providing coverage
    on terms and conditions that are no less advantageous to the Indemnified
    Parties, and (ii) Parent may satisfy its obligations hereunder by extending
    the discovery or reporting period under such policy for six years from the
    Effective Time to maintain in effect directors' and officers' liability
    insurance covering pre-acquisition acts (including acts in connection with
    this Agreement and the transactions contemplated hereby) for the Indemnified
    Parties on terms no less favorable than the terms of such current insurance
    coverage; provided, however, that in no event shall Parent be required to
    expend for any such coverage an amount per year in excess of $798,000; and
    provided further that if the cost per year of such coverage exceeds
    $798,000, Parent shall be obligated to obtain such coverage as is available
    for a cost per year not
 
                                      A-31
<PAGE>
    exceeding such amount. The Company represents that the annual premium
    currently paid by the Company for such insurance is approximately $399,000.
 
        (c) In the event Parent, the Surviving Corporation or any of their
    successors or assigns (i) consolidates with or merges into any other person
    or entity and shall not be the continuing or surviving corporation or entity
    of such consolidation or merger or (ii) transfers all or substantially all
    of its properties and assets to any person, then and in each such case,
    proper provisions shall be made so that the successors and assigns of Parent
    or the Surviving Corporation, as the case may be, shall assume the
    obligations set forth in this Section 5.15.
 
        (d) This Section 5.15 shall survive the consummation of the Merger at
    the Effective Time, is intended to benefit the Indemnified Parties, may be
    enforced by the Indemnified Parties as third party beneficiaries and shall
    be binding on all successors and assigns of Parent and the Surviving
    Corporation.
 
    5.16  LETTERS OF THE COMPANY'S AND PARENT'S ACCOUNTANTS.
 
        (a) The Company shall cooperate with Parent and use reasonable best
    efforts to cause to be delivered to Parent and the Company, letters from
    Ernst & Young LLP addressed to the Company, as of the Closing Date, stating
    that based upon discussions with officials of the Company responsible for
    financial and accounting matters, and information furnished to Ernst & Young
    LLP to the date of its letter, Ernst & Young LLP concurs with the Company's
    management's conclusion that, as of the date of its letter, no conditions
    exist related to the Company that would preclude Parent's accounting for the
    merger with the Company as a pooling of interests.
 
        (b) The Company shall cooperate with Parent and Parent shall use
    reasonable best efforts to cause to be delivered to the Company and Parent,
    letters from PricewaterhouseCoopers LLP addressed to Parent, dated as of the
    Closing Date, confirming as of the Closing Date that the Merger will qualify
    as a pooling of interests transaction under Opinion 16 of the Accounting
    Principles Board and applicable SEC rules and regulations.
 
    5.17  SUBSIDIARY SHARES.  At or prior to the Closing, the Company shall use
commercially reasonable efforts to cause all issued and outstanding Subsidiary
shares (other than any interests in joint ventures or similar arrangements)
owned by any person other than the Company or any of its Subsidiaries to be
transferred for no or nominal consideration to such qualified person or persons
designated by Parent.
 
    5.18  BENEFIT PLANS AND EMPLOYEE MATTERS.
 
        (a) From and after the Effective Time, Parent shall to the extent
    practicable cause the Surviving Corporation to provide employee benefits and
    programs to the Company's and its Subsidiaries' employees that, in the
    aggregate, are substantially comparable to or more favorable than those in
    existence as of the date hereof and disclosed in writing to Parent prior to
    the date hereof; PROVIDED THAT stock-based compensation shall be comparable,
    in the aggregate, to that offered by Parent and its subsidiaries generally.
    To the extent Parent satisfies its obligations under this Section by
    maintaining Company benefit plans, Parent shall not be required to include
    employees of the Company in Parent's benefit plans. From and after the
    Effective Time, Parent shall honor, in accordance with their terms, all
    employment and severance agreements and all severance, incentive and bonus
    plans as in effect immediately prior to the Closing Date that are applicable
    to any current or former employees or directors of the Company or any of its
    Subsidiaries and that are disclosed in the Company Disclosure Schedule.
 
        (b) To the extent that service is relevant for purposes of eligibility,
    level of participation, or vesting under any employee benefit plan, program
    or arrangement established or maintained by Parent, the Company or any of
    their respective subsidiaries, employees of the Company and its Subsidiaries
    shall be credited for service accrued or deemed accrued prior to the
    Effective Time with the Company or such Subsidiary, as the case may be.
    Under no circumstances shall employees receive credit for service accrued or
    deemed accrued prior to the Effective Time with the Company or such
 
                                      A-32
<PAGE>
    Subsidiary, as the case may be, for benefit accruals under any employee
    pension benefit plan (as defined by Section 3(2) of ERISA) or any retiree
    health plan.
 
        (c) As soon as reasonably practicable after the Effective Time, Parent
    shall take whatever action is reasonably necessary to provide for a special
    phase under Parent's employee stock purchase plan (the "Parent ESPP") to
    permit those employees of the Surviving Corporation who have satisfied the
    eligibility requirements of the Parent ESPP to purchase Parent Common Stock
    under the Parent ESPP, with such phase to be operated under the terms and
    conditions of the Parent ESPP.
 
    5.19  OBLIGATIONS OF MERGER SUBSIDIARY.  Parent shall take all action
necessary to cause Merger Subsidiary to perform its obligations under this
Agreement and to consummate the Merger on the terms and subject to the
conditions set forth in this Agreement.
 
    5.20  PLAN OF REORGANIZATION.  This Agreement is intended to constitute a
"plan of reorganization" within the meaning of Section 1.368-2(g) of the income
tax regulations promulgated under the Code. From and after the date of this
Agreement and after the Effective Time, each party hereto shall use reasonable
best efforts to cause the Merger to qualify, and shall not, without the prior
written consent of the other parties hereto, knowingly take any actions or cause
any actions to be taken which could prevent the Merger from qualifying as a
reorganization under the provisions of Section 368(a) of the Code.
 
    5.21  POOLING.  From and after the date of this Agreement and until the
Effective Time, neither Parent nor the Company, nor any of their respective
subsidiaries or other affiliates, shall knowingly take any action, or knowingly
fail to take any action, that is reasonably likely to jeopardize the treatment
of the Merger as a "pooling of interests" for accounting purposes. Between the
date of this Agreement and the Effective Time, Parent and the Company each shall
use reasonable best efforts to cause the characterization of the Merger as a
pooling of interests for accounting purposes if such a characterization were
jeopardized by action taken by Parent or the Company, respectively, prior to the
Effective Time. Following the Effective Time, Parent shall not knowingly take
any action, or fail to take any action, that would jeopardize the
characterization of the Merger as a "pooling of interests" for accounting
purposes.
 
    5.22  TAX MATTERS.  At or prior to the filing of the Registration Statement
and at or prior to the Closing, the Company and Parent shall execute and deliver
to Cooley Godward LLP and to Fredrikson & Byron, P.A. tax representation letters
reasonably satisfactory to such counsel setting forth customary representations
which may be relied upon by such counsel in rendering any opinions contemplated
by this Agreement. Parent shall use commercially reasonable efforts to cause
Fredrikson & Byron, P.A. to deliver to Parent a legal opinion, satisfying the
requirements of Item 601 of Regulation S-K promulgated under the 1933 Act and
dated as of a date that is no more than two business days prior to the date of
filing of the Registration Statement, to the effect that the Merger will
constitute a reorganization within the meaning of Section 368(a) of the Code,
based in part on the tax representation letters described in this Section 5.22.
The Company shall use commercially reasonable efforts to cause Cooley Godward
LLP to deliver to the Company a legal opinion, satisfying the requirements of
Item 601 of Regulation S-K promulgated under the 1933 Act and dated as of a date
that is no more than two business days prior to the date of filing of the
Registration Statement, to the effect that the Merger will constitute a
reorganization within the meaning of Section 368(a) of the Code, based in part
on the tax representation letters described in this Section 5.22.
 
                                   ARTICLE 6
                               CLOSING CONDITIONS
 
    6.1  CONDITIONS TO OBLIGATIONS OF PARENT, MERGER SUBSIDIARY, AND THE
COMPANY.  The respective obligations of each party to consummate the Merger
shall be subject to the fulfillment at or prior to the Closing of the following
conditions, any or all of which may be waived, in whole or in part, to the
extent permitted by applicable law:
 
        (a)  NO INJUNCTION.  None of Parent, Merger Subsidiary, or the Company
    shall be subject to any final order, decree, or injunction of a court of
    competent jurisdiction within the United States that is then in effect and
    (i) has the effect of making the Merger illegal or otherwise prohibiting the
 
                                      A-33
<PAGE>
    consummation of the Merger, or (ii) would impose any material limitation on
    the ability of Parent to effectively exercise full rights of ownership of
    the stock of the Surviving Corporation or of the Surviving Corporation to
    own and operate the assets and business of the Company.
 
        (b)  STOCKHOLDER APPROVAL.  The approval of the stockholders of the
    Company referred to in Section 5.5 hereof shall have been obtained, in
    accordance with the DGCL and the Company's Certificate of Incorporation and
    Bylaws.
 
        (c)  REGISTRATION STATEMENT.  The Registration Statement (as amended or
    supplemented) shall have become effective under the 1933 Act and shall not
    be subject to any "stop order," and no action, suit, proceeding, or
    investigation by the SEC to suspend the effectiveness thereof shall have
    been initiated and be continuing.
 
        (d)  NYSE LISTING.  The shares of Parent Common Stock to be delivered
    pursuant to the Merger shall have been duly authorized for listing on the
    NYSE, subject to official notice of issuance.
 
        (e)  WAITING PERIODS.  The waiting periods (and any extension thereof)
    applicable to the consummation of the Merger under the HSR Act and any
    Foreign Merger Laws shall have expired or been terminated.
 
    6.2  CONDITIONS TO OBLIGATIONS OF PARENT AND MERGER SUBSIDIARY.  The
respective obligations of Parent and Merger Subsidiary to consummate the Merger
shall be subject to the fulfillment at or prior to the Closing of the following
additional conditions, any or all of which may be waived by Parent, in whole or
in part, to the extent permitted by applicable Law:
 
        (a)  REPRESENTATIONS AND WARRANTIES TRUE.  Each representation and
    warranty of the Company contained in this Agreement, without regard to any
    qualification or reference to "Company Material Adverse Effect," shall be
    true and correct on the Closing Date as though such representations and
    warranties were made on such date, except that those representations and
    warranties that address matters only as of the date hereof or another
    particular date shall remain true and correct as of such date, and except in
    any case for any inaccuracies that have not had, or would not reasonably be
    expected to have, a Company Material Adverse Effect; provided, however,
    notwithstanding the foregoing, this Section 6.2(a) shall not be considered
    fulfilled or satisfied if the representation and warranty set forth in the
    last sentence of Section 3.3 is incorrect as of the Closing Date by
    understating the number of shares of Company Common Stock by more than
    20,000 shares. Parent shall have received a certificate to the foregoing
    effect signed by the Chief Executive Officer of the Company or other
    authorized Officer of the Company.
 
        (b)  PERFORMANCE.  The Company shall have performed and complied in all
    material respects with all material covenants required by this Agreement to
    be performed or complied with by it at or prior to the Closing, and Parent
    shall have received a certificate to such effect signed by the Chief
    Executive Officer of the Company or other authorized Officer of the Company
    (provided that for purposes of this subsection (b), actions of
    representatives or agents of the Company who are not officers, directors or
    employees of the Company which do not result in a proposal for an
    Alternative Transaction shall not be deemed to be a breach of Section 5.3 so
    long as the Company has used commercially reasonable efforts to cause such
    representatives and agents to comply with Section 5.3).
 
        (c)  AFFILIATES' LETTERS.  Parent shall have received a letter from each
    of the Affiliates pursuant to Section 5.7 hereof.
 
        (d)  POOLING OPINION.  Parent shall have received each of the letters
    described in Section 5.16.
 
        (e)  CONTINUED EMPLOYMENT OF KEY EXECUTIVES.  There shall not have been
    since the date hereof any termination of employment (excluding any
    termination due to death or disability) involving the Chief Executive
    Officer or a majority of the other executive officers of the Company as of
    the date hereof, or any notice or announcement that such Chief Executive
    Officer or a majority of such other executive officers of the Company as of
    the date hereof will not continue their employment with the Surviving
    Corporation after the Merger.
 
                                      A-34
<PAGE>
    6.3  CONDITIONS TO OBLIGATION OF THE COMPANY.  The obligation of the Company
to consummate the Merger shall be subject to the fulfillment at or prior to the
Closing of the following additional conditions, any or all of which may be
waived by the Company, in whole or in part, to the extent permitted by
applicable law:
 
        (a)  REPRESENTATIONS AND WARRANTIES TRUE.  Each representation and
    warranty of Parent contained in this Agreement, without regard to any
    qualification or reference to "Parent Material Adverse Effect," shall be
    true and correct on the Closing Date as though such representations and
    warranties were made on such date, except that those representations and
    warranties that address matters only as of the date hereof or another
    particular date shall remain true and correct as of such date, and except in
    any case for any inaccuracies that have not had, or would not reasonably be
    expected to have a Parent Material Adverse Effect. The Company shall have
    received a certificate to the foregoing effect signed by the Chief Executive
    Officer or other authorized officer of Parent.
 
        (b)  PERFORMANCE.  Parent and Merger Subsidiary shall have performed and
    complied in all material respects with all material covenants required by
    this Agreement to be performed or complied with by them at or prior to the
    Closing, and the Company shall have received a certificate to such effect
    signed by the Chief Executive Officer or other authorized officer of Parent.
 
        (c)  TAX OPINION.  The Company shall have received an opinion of Cooley
    Godward LLP, counsel to the Company, addressed to the Company's
    stockholders, based upon representations of Parent, Merger Subsidiary and
    the Company and normal assumptions, and dated on or about the date that is
    two business days prior to the date the Proxy Statement/Prospectus is first
    mailed to Company's stockholders, which opinion shall not have been
    withdrawn or modified in any material respect prior to the Effective Time,
    to the effect that, subject to customary conditions and representations, the
    Merger will be treated for federal income tax purposes as a reorganization
    within the meaning of Section 368(a) of the Code, and that each of Parent,
    Merger Subsidiary and the Company will be considered a party to such
    reorganization. Parent, Merger Subsidiary and the Company hereby agree to
    provide to such counsel certificates acceptable to such counsel setting
    forth the customary representations which may be relied upon by such counsel
    in rendering such opinion.
 
        (d)  POOLING OPINION.  The Company shall have received each of the
    letters described in Section 5.16.
 
                                   ARTICLE 7
                          TERMINATION AND ABANDONMENT
 
    7.1  TERMINATION.  This Agreement may be terminated at any time prior to the
Effective Time, whether before or after approval by the stockholders of the
Company, only:
 
        (a) by mutual written consent duly authorized by the Board of Directors
    of Parent and the Board of Directors of the Company;
 
        (b) by either Parent or the Company if the Merger shall not have been
    consummated on or before May 31, 1999; provided, however, that the
    terminating party shall not have breached in any material respect its
    obligations under this Agreement in any manner that shall have been the
    proximate cause of, or resulted in, the failure to consummate the Merger by
    such date and provided further, however, that, if a request for additional
    information is received from the U.S. Federal Trade Commission ("FTC") or
    Department of Justice ("DOJ") pursuant to the HSR Act or additional
    information is requested by a governmental authority (a "Foreign Authority")
    pursuant to Foreign Merger Laws, such date shall be extended to the 90th day
    following acknowledgment by the FTC, DOJ, or Foreign Authority, as
    applicable, that Parent and the Company have complied with such request, but
    in any event not later than October 31, 1999;
 
                                      A-35
<PAGE>
        (c) by either Parent or the Company if a court of competent jurisdiction
    or an administrative, governmental, or regulatory authority has issued a
    final nonappealable order, decree, or ruling, or taken any other action,
    having the effect of permanently restraining, enjoining, or otherwise
    prohibiting the Merger;
 
        (d) by either Parent or the Company if, at the Company Stockholders
    Meeting, the requisite vote of the stockholders of the Company for approval
    and adoption of this Agreement and the Merger is not obtained, except that
    the right to terminate this Agreement under this Section 7.1(d) will not be
    available to any party whose failure to perform any material obligation
    under this Agreement has been the proximate cause of, or resulted in, the
    failure to obtain the requisite vote of the stockholders of the Company;
 
        (e) by Parent if either (i) the Company has breached its obligations
    under Section 5.3 in any material respect (provided that for purposes of
    this clause (i), actions of representatives or agents of the Company who are
    not officers, directors or employees of the Company which do not result in a
    proposal for an Alternative Transaction shall not be deemed to be a breach
    of Section 5.3 so long as the Company has used commercially reasonable
    efforts to cause such representatives and agents to comply with Section
    5.3), (ii) the Board of Directors of the Company has recommended, approved,
    or authorized the Company's acceptance or execution of a definitive
    agreement providing for an Alternative Transaction, as defined in Section
    5.3, (iii) the Board of Directors of the Company has modified in a manner
    materially adverse to Parent or withdrawn its recommendation of this
    Agreement, or (iv) a tender offer or exchange offer for any outstanding
    shares of Company Common Stock is commenced, and the Board of Directors of
    the Company, within 10 business days after such tender offer or exchange
    offer is so commenced, either fails to recommend against acceptance of such
    tender offer or exchange offer by its stockholders or takes no position with
    respect to the acceptance of such tender offer or exchange offer by its
    stockholders;
 
        (f) by the Company prior to the Required Company Stockholder Vote if (i)
    it is not in breach of its obligations under Section 5.5 in any material
    respect and has complied with, and continues to comply with, all
    requirements and procedures of Section 5.3 in all material respects, (ii)
    the Board of Directors of the Company has complied with, and continues to
    comply with, all requirements and procedures of Section 5.3 in all material
    respects and has authorized, subject to complying with the terms of this
    Agreement, the Company to enter into a binding written agreement concerning
    a transaction that constitutes a Superior Proposal and the Company notifies
    Parent in writing that it intends to enter into such agreement, attaching
    the most current version of such agreement to such notice, (iii) Parent does
    not make, within ten business days after receipt of the Company's written
    notice of its intention to enter into a binding agreement for a Superior
    Proposal, any offer that the Board of Directors of the Company reasonably
    and in good faith determines, after consultation with its financial and
    legal advisors, is at least as favorable to the stockholders of the Company
    as the Superior Proposal and during such ten business-day period the Company
    reasonably considers and discusses in good faith all proposals submitted by
    Parent and, without limiting the foregoing, meets with, and causes its
    financial advisors and legal advisors to meet with, Parent and its advisors
    from time to time as requested by Parent to reasonably consider and discuss
    in good faith Parent's proposals, and (iv) prior to the Company's
    termination pursuant to this Section 7.1(f), the Company pays to Parent the
    fee required by Section 7.2 to be paid to Parent in the manner therein
    provided. The Company agrees (x) that it will not enter into a binding
    agreement referred to in clause (ii) above until at least the 11th business
    day after Parent has received the notice to Parent required by clause (ii)
    above, and (y) to notify Parent promptly if its intention to enter into a
    binding agreement referred to in its notice to Parent shall change at any
    time after giving such notice;
 
        (g) by Parent if (i) Parent is not in material breach of its obligations
    under this Agreement and (ii) there has been a material breach by the
    Company of any of its representations, warranties, or obligations under this
    Agreement such that the conditions in Section 6.2 will not be satisfied
 
                                      A-36
<PAGE>
    ("Terminating Company Breach"); provided, however, that, if such Terminating
    Company Breach is curable by the Company through the exercise of reasonable
    best efforts and such cure is reasonably likely to be completed prior to the
    applicable date specified in Section 7.1(b), then for so long as the Company
    continues to exercise reasonable best efforts, Parent may not terminate this
    Agreement under this Section 7.1(g); and provided further that for purposes
    of this subsection (g), actions of representatives or agents of the Company
    who are not officers, directors or employees of the Company which do not
    result in a proposal for an Alternative Transaction shall not be deemed to
    be a breach of Section 5.3 so long as the Company has used commercially
    reasonable efforts to cause such representatives and agents to comply with
    Section 5.3); or
 
        (h) by the Company if (i) the Company is not in material breach of its
    obligations under this Agreement and (ii) there has been a material breach
    by Parent of any of its representations, warranties, or obligations under
    this Agreement such that the conditions in Section 6.3 will not be satisfied
    ("Terminating Parent Breach"); provided, however, that, if such Terminating
    Parent Breach is curable by Parent through the exercise of reasonable best
    efforts and such cure is reasonably likely to be completed prior to the
    applicable date specified in Section 7.1(b), then for so long as Parent
    continues to exercise reasonable best efforts, the Company may not terminate
    this Agreement under this Section 7.1(h).
 
    7.2  EFFECT OF TERMINATION.
 
        (a) In recognition of the time, efforts, and expenses expended and
    incurred by Parent with respect to the Company and the opportunity that the
    acquisition of the Company presents to Parent, if:
 
           (i) this Agreement is validly terminated pursuant to Section 7.1(e)
       or 7.1(f); or
 
           (ii) (A) this Agreement is validly terminated by Parent or the
       Company pursuant to Section 7.1(d) due to the failure of the Company's
       stockholders to approve the Merger, (B) at any time between the date
       hereof and the time of such failure to so approve the Merger, a proposal
       for a Competing Transaction shall have been publicly announced, (C)
       within 12 months after the date of such termination, the Company shall
       have entered into a definitive agreement with a Third Party providing for
       a Competing Transaction, and (D) a Competing Transaction is consummated
       by the Company with the same Third Party that entered into the definitive
       agreement referenced in clause (C) above or any affiliate of such Third
       Party within two years after entering into the agreement referenced in
       clause (C) above;
 
    then, in any such event (but subject to Section7.2(c)), the Company will pay
    to Parent, upon the termination date in the event of termination pursuant to
    Section 7.1(f), within five business days after demand by Parent in the case
    of termination pursuant to Section 7.1(e), or within five business days
    after consummating the Competing Transaction referenced in clause (ii) (D)
    above in the case of the events specified in clause (ii) above (by wire
    transfer of immediately available funds to an account designated by Parent
    for such purpose), a fee equal to $135,000,000. For purposes of this
    Agreement, "Competing Transaction" means: (i) any consolidation, exchange of
    shares or merger of the Company with any Third Party, other than a
    consolidation, exchange or shares or merger as a result of which the holders
    of Company Common Stock immediately prior to such transaction beneficially
    own 50% or more of the voting stock of the Company, the surviving
    corporation or any parent entity immediately after the transaction, (ii) any
    transaction or series of related transactions pursuant to which a Third
    Party acquires shares (or securities exercisable for or convertible into
    shares) representing more than 50% of the outstanding shares of any class of
    capital stock of the Company; or (iii) any sale, lease, exchange, licensing,
    transfer or other disposition pursuant to which a Third Party acquires
    control of more than 50% of the assets (including, but not limited to,
    intellectual property assets) of the Company and its Subsidiaries taken as a
    whole (determined by reference to the fair market value of such assets), in
    a single transaction or series of related transactions.
 
                                      A-37
<PAGE>
        (b) The Company acknowledges that the agreements contained in this
    Section 7.2 are an integral part of the transactions contemplated by this
    Agreement and are not a penalty, and that, without these agreements, Parent
    would not enter into this Agreement. If the Company fails to pay promptly
    the fee due pursuant to Section 7.2(a), the Company shall also pay to Parent
    Parent's costs and expenses (including legal fees and expenses) in
    connection with any action, including the filing of any lawsuit or other
    legal action, taken to collect payment, together with interest on the amount
    of the unpaid fee under this section, accruing from its due date, at an
    interest rate per annum equal to two percentage points in excess of the
    prime commercial lending rate quoted by Norwest Bank Minnesota, N.A.;
    provided, however, that Parent shall pay to the Company the Company's costs
    and expenses (including legal fees and expenses) incurred in connection with
    any such legal action if Parent's claims against the Company in such legal
    action do not prevail. Any change in the interest rate hereunder resulting
    from a change in such prime rate shall be effective at the beginning of the
    day of such change in such prime rate.
 
        (c) Parent agrees that the payment provided for in Section 7.2(a) shall
    be the sole and exclusive remedy of Parent upon termination of this
    Agreement pursuant to Section 7.1(e) and 7.1(f), as the case may be, and
    such remedy shall be limited to the sum stipulated in such Section 7.2(a),
    regardless of the circumstances giving rise to such termination; provided,
    however, that nothing herein shall relieve any party from liability for the
    willful breach of any of its representations, warranties, covenants or
    agreements set forth in this Agreement. In no event shall the Company be
    required to pay to Parent more than one fee pursuant to Section 7.2(a). In
    no event shall the sum of (i) the termination fee paid pursuant to Section
    7.2(a), (ii) the Cancellation Amount (as defined in the Stock Option
    Agreement) paid pursuant to the Stock Option Agreement, (iii) the aggregate
    Option Share Profit (as defined in the Stock Option Agreement) not remitted
    to the Company pursuant to Section 2(c) of the Stock Option Agreement, and
    (iv) the Section 5 Repurchase Consideration (as defined in the Stock Option
    Agreement) paid to Parent exceed $150,000,000. In addition, the fee payable
    by the Company pursuant to Section 7.2(a) shall be reduced (but not below
    zero) by any Cancellation Amount paid pursuant to the Stock Option
    Agreement, any Option Share Profit not remitted to the Company pursuant to
    Section 2(c) of the Stock Option Agreement and any Section 5 Repurchase
    Consideration paid pursuant to the Stock Option Agreement. Except as
    provided in the next sentence of this paragraph, in the event of the
    termination of this Agreement pursuant to any paragraph of Section 7.1, the
    obligations of the parties to consummate the Merger will expire, and none of
    the parties will have any further obligations under this Agreement except
    pursuant to Sections 5.4(b), 5.8, 7.2(a), 7.2(b) and 7.2(c) and Article 8.
    Nothing herein shall relieve any party from liability for the willful breach
    of any of its representations, warranties, covenants or agreements set forth
    in this Agreement.
 
                                   ARTICLE 8
                                 MISCELLANEOUS
 
    8.1  AMENDMENT AND MODIFICATION.  Subject to applicable law, this Agreement
may be amended, modified, or supplemented only by written agreement of Parent,
Merger Subsidiary, and the Company at any time prior to the Effective Time with
respect to any of the terms contained herein; provided, however, that, after the
approval of this Agreement by the stockholders of the Company, no amendment may
be made which would reduce the amount or change the type of consideration into
which each share of Company Common Stock shall be converted upon consummation of
the Merger or which would otherwise require stockholder approval under
applicable law unless such stockholder approval shall have been obtained. This
Agreement may not be amended except by an instrument in writing signed on behalf
of each of the parties hereto.
 
    8.2  WAIVER OF COMPLIANCE; CONSENTS.  Any failure of Parent or Merger
Subsidiary on the one hand, or the Company on the other hand, to comply with any
obligation, covenant, agreement, or condition
 
                                      A-38
<PAGE>
herein may be waived by the Company or Parent, respectively, only by a written
instrument signed by an officer of the party granting such waiver, but such
waiver or failure to insist upon strict compliance with such obligation,
covenant, agreement, or condition shall not operate as a waiver of, or estoppel
with respect to, any subsequent or other failure. Whenever this Agreement
requires or permits consent by or on behalf of any party hereto, such consent
shall be given in writing. Merger Subsidiary agrees that any consent or waiver
of compliance given by Parent hereunder shall be conclusively binding upon
Merger Subsidiary, whether or not given expressly on its behalf.
 
    8.3  INVESTIGATION; SURVIVAL OF REPRESENTATIONS AND WARRANTIES.  The
respective representations and warranties of Parent and the Company contained
herein or in any certificates or other documents delivered prior to or at the
Closing shall not be deemed waived or otherwise affected by any investigation
made by any party hereto. The representations, warranties and agreements in this
Agreement and in any certificate delivered pursuant hereto shall terminate at
the Effective Time, except that the agreements set forth in Articles I and II
and Sections 5.7(b), 5.8, 5.9, 5.15, 5.18, 5.19, 5.20, 5.21 and this Article
VIII shall survive the Effective Time.
 
    8.4  NOTICES.  All notices and other communications hereunder shall be in
writing and shall be deemed given when delivered personally by commercial
courier service or otherwise, or by telecopier, or three days after such notice
is mailed by registered or certified mail (return receipt requested) to the
parties at the following addresses (or at such other address for a party as
shall be specified by like notice):
 
        (a) If to Parent or Merger Subsidiary, to it at:
 
           Medtronic, Inc.
           7000 Central Avenue N.E.
           Minneapolis, MN 55432
 
           with separate copies thereof addressed to:
 
           Attention: General Counsel
                    FAX: (612) 572-5459
 
           and
 
           Attention: Vice President and Chief Development Officer
                    FAX: (612) 572-5404
 
        (b) If to the Company, to it at:
 
           Arterial Vascular Engineering, Inc.
           3576 Unocal Place
           Santa Rosa, CA 95403
           FAX: (707) 541-3190
           Attention: General Counsel
 
           with a copy to:
 
           Cooley Godward LLP
           5 Palo Alto Square
           3000 El Camino Real
           Palo Alto, CA 94306
           FAX: (650) 857-0663
           Attention: Craig E. Dauchy, Esq. and
 
                      Richard E. Climan, Esq.
 
    8.5  ASSIGNMENT.  This Agreement and all of the provisions hereof shall be
binding upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns, but neither this
 
                                      A-39
<PAGE>
Agreement nor any of the rights, interests, or obligations hereunder shall be
assigned by any of the parties hereto without the prior written consent of the
other parties. Except for the provisions of Article II and Section 5.15 (the
"Third Party Provisions"), this Agreement is not intended to confer upon any
other person, except the parties hereto, any rights or remedies hereunder, and
no third person shall be a third party beneficiary of this Agreement. The Third
Party Provisions may be enforced by the beneficiaries thereof.
 
    8.6  GOVERNING LAW.  Except to the extent that Delaware law is mandatorily
applicable, this Agreement shall be governed by the laws of the State of
Minnesota (regardless of the laws that might otherwise govern under applicable
Minnesota principles of conflicts of law). The parties hereby (i) agree and
consent to be subject to the jurisdiction of any state or federal court in the
state of Delaware or in Minneapolis or St. Paul, Minnesota, with respect to all
actions and proceedings arising out of or relating to this Agreement (although
each party reserves the right to bring such action or proceedings in any other
jurisdiction to which the other party is subject); (ii) agree that all claims
with respect to any such action or proceeding may be heard and determined in
such court; (iii) irrevocably waive any defense of an inconvenient forum to the
maintenance of any action or proceeding in such court; (iv) consent to service
of process by mailing or delivering such service to the party at its respective
principal business address; and (v) agree that a final judgment in any such
action or proceeding from which there is no further appeal shall be conclusive
and may be enforced in any other jurisdictions by suit on the judgment or in any
manner provided by law.
 
    8.7  COUNTERPARTS.  This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, and all of which
together shall constitute one and the same instrument.
 
    8.8  KNOWLEDGE.  As used in this Agreement or the instruments, certificates
or other documents required hereunder, the term "knowledge" of a party hereto
shall mean actual knowledge of the directors or executive officers of such
party.
 
    8.9  INTERPRETATION.  The Table of Contents, article and section headings
contained in this Agreement are inserted for reference purposes only and shall
not affect the meaning or interpretation of this Agreement. This Agreement shall
be construed without regard to any presumption or other rule requiring the
resolution of any ambiguity regarding the interpretation or construction hereof
against the party causing this Agreement to be drafted.
 
    8.10  PUBLICITY.  Upon execution of this Agreement by Parent, Merger
Subsidiary, and the Company, the parties shall jointly issue a press release, as
agreed upon by them. The parties intend that all future statements or
communications to the public or press regarding this Agreement or the Merger
will be mutually agreed upon by them. Neither party shall, without such mutual
agreement or the prior consent of the other, issue any statement or
communication to the public or to the press regarding this Agreement, or any of
the terms, conditions, or other matters with respect to this Agreement, except
as required by law or the rules of the NYSE or Nasdaq and then only (a) upon the
advice of such party's legal counsel; (b) to the extent required by law or the
rules of the NYSE or Nasdaq; and (c) following prior notice to, and consultation
with, the other party (which notice shall include a copy of the proposed
statement or communication to be issued to the press or public). The foregoing
shall not restrict Parent's or the Company's communications with their employees
or customers in the ordinary course of business.
 
    8.11  ENTIRE AGREEMENT.  This Agreement, including the exhibits and
schedules hereto and the Confidentiality Agreement referred to herein, embodies
the entire agreement and understanding of the parties hereto in respect of the
subject matter contained herein. This Agreement and the Confidentiality
Agreement supersede all prior agreements and the understandings between the
parties with respect to such subject matter.
 
    8.12  SEVERABILITY.  If any term or other provision of this Agreement is
invalid, illegal or incapable of being enforced by any rule of law or public
policy, all other conditions and provisions of this Agreement shall nevertheless
remain in full force and effect so long as the economic or legal substance of
the
 
                                      A-40
<PAGE>
transactions contemplated by this Agreement is not affected in any manner
materially adverse to any party. Upon such determination that any term or other
provision is invalid, illegal or incapable of being enforced, the parties hereto
shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties as closely as possible in a mutually acceptable
manner in order that the transactions contemplated by this Agreement be
consummated as originally contemplated to the fullest extent possible.
 
    8.13  SPECIFIC PERFORMANCE.  The parties hereto agree that irreparable
damage would occur in the event any provision of this Agreement was not
performed in accordance with the terms hereof and that the parties shall be
entitled to specific performance of the terms hereof, in addition to any other
remedy at law or in equity.
 
    IN WITNESS WHEREOF, the parties hereto have executed this Agreement and Plan
of Merger as of the date first above written.
 
<TABLE>
<S>                             <C>  <C>
                                MEDTRONIC, INC.
 
                                By:            /s/ MICHAEL D. ELLWEIN
                                     -----------------------------------------
                                       Michael D. Ellwein, Vice President and
                                                       Chief
                                                Development Officer
 
                                MAV MERGER CORP.
 
                                By:            /s/ MICHAEL D. ELLWEIN
                                     -----------------------------------------
                                           Michael D. Ellwein, President
 
                                ARTERIAL VASCULAR ENGINEERING, INC.
 
                                By:  /s/ LAWRENCE J. FASSLER
                                     -----------------------------------------
                                     Its: Vice President, General Counsel and
                                        Secretary
</TABLE>
 
                                      A-41
<PAGE>
                                    ANNEX B
 
           November 29, 1998
 
 [LOGO]
 
           Board of Directors
           Arterial Vascular Engineering, Inc.
           3576 Unocal Place
           Santa Rosa, CA 95403
 
           Members of the Board of Directors:
 
               You have requested our opinion as to the fairness, from a
           financial point of view, to the stockholders of Arterial Vascular
           Engineering, Inc., a Delaware corporation (the "Company"), of the
           Conversion Ratio (as defined below) provided for in that certain
           Agreement and Plan of Merger dated as of the date hereof (the
           "Transaction Agreement"), by and among the Company, Medtronic, Inc.,
           a Minnesota corporation (the "Parent"), and MAV Merger Corp., a
           Delaware corporation and wholly owned subsidiary of the Parent
           ("Merger Subsidiary").
 
               As more specifically set forth in the Transaction Agreement, and
           subject to the terms and conditions thereof, the Company has agreed
           to be acquired by the Parent through the merger of Merger Subsidiary
           with and into the Company, with the Company as the surviving company
           (the "Merger"). In the Merger, among other things, each share of the
           common stock of the Company, par value $0.001 per share ("Company
           Common Stock"), outstanding as of the effective time of the Merger
           other than shares held in the treasury of the Company or owned
           beneficially or of record by the Parent or any direct or indirect
           wholly owned subsidiary of the Parent or the Company, will be
           converted into the right to receive a number of shares (the
           "Conversion Ratio") of the common stock of the Parent, par value
           $0.10 per share ("Parent Common Stock"), equal to the quotient of (i)
           $54.00 divided by (ii) the Parent Average Stock Price (as defined
           below), provided, that if the Parent Average Stock Price is equal to
           or less than $61.20, then the Conversion Ratio will be equal to
           0.88235, and that if the Parent Average Stock Price is equal to or
           greater than $74.80, then the Conversion Ratio will be equal to
           0.72193.
 
               For purposes of the determination above, "Parent Average Stock
           Price" shall equal the average (rounded to the nearest full cent,
           with the cents rounded up if the third decimal place is 5 or more) of
           the daily closing sale prices of a share of Parent Common Stock as
           reported on the New York Stock Exchange ("NYSE") Composite Tape, as
           reported in THE WALL STREET JOURNAL, for the fifteen consecutive NYSE
           trading days ending on and including the NYSE trading day that is two
           NYSE trading days prior to the Company Stockholders Meeting (as
           defined in the Transaction Agreement).
 
       SG COWEN SECURITIES CORPORATION
       Four Embarcadero Center
       Suite 1200
       San Francisco, CA 94111                     B-1
<PAGE>
      Board of Directors
      Arterial Vascular Engineering, Inc.
      November 29, 1998
      Page 2 of 4
 
               SG Cowen Securities Corporation ("SG Cowen"), as part of its
           investment banking business, is continually engaged in the valuation
           of businesses and their securities in connection with mergers and
           acquisitions, negotiated underwritings, secondary distributions of
           listed and unlisted securities, private placements and valuations for
           corporate and other purposes. In the ordinary course of our business,
           we and our affiliates actively trade the equity securities of the
           Company and the Parent for our own account and for the accounts of
           our customers and, accordingly, may at any time hold a long or short
           position in such securities.
 
               We are acting as financial advisor to the Board of Directors of
           the Company in connection with the Merger and will receive a fee from
           the Company for our services pursuant to the terms of our engagement
           letter with the Company, dated as of March 3, 1997 (the "Engagement
           Letter"), the payment of which is contingent upon the consummation of
           the Merger. Societe Generale, the sole shareholder of SG Cowen, and
           its affiliates, including SG Cowen, in the ordinary course of
           business have from time to time provided, and in the future may
           continue to provide, commercial and investment banking services to
           the Company, including serving as financial advisor on potential
           acquisitions and as an underwriter on equity offerings, and have
           received fees for the rendering of such services. In particular, SG
           Cowen acted as lead manager of the Company's initial public offering
           in April 1996, and was selected to serve as co-manager on a proposed
           secondary offering which was subsequently withdrawn before filing. SG
           Cowen also is acting as financial advisor to the Company in
           connection with the pending acquisition by the Company of World
           Medical Manufacturing Corporation, and will receive a fee for its
           services in connection with that transaction, a significant portion
           of which is contingent upon the consummation of that transaction.
 
               In connection with our opinion, we have reviewed and considered
           such financial and other matters as we have deemed relevant,
           including, among other things:
 
                   (i) the Transaction Agreement provided to us by the Company;
 
                   (ii) certain publicly available information for the Company,
               including each of the annual reports of the Company filed on Form
               10-K for the fiscal years ended June 30, 1996, 1997 and 1998 and
               the quarterly report on Form 10-Q for the fiscal quarter ended
               September 30, 1998, and certain other relevant financial and
               operating data for the Company furnished to SG Cowen by
               management of the Company;
 
                   (iii) certain publicly available information for the Parent,
               including each of the annual reports of the Parent filed on Form
               10-K for the fiscal years ended April 30, 1996, 1997 and 1998,
               the quarterly report on Form 10-Q for the fiscal quarter ended
               July 31, 1998 and the unaudited financial statements for the
               fiscal quarter ended October 31, 1998, and certain other relevant
               financial and operating data for the Parent furnished to SG Cowen
               by management of the Parent;
 
                   (iv) discussions we have had with management and senior
               personnel of each of the Company and the Parent concerning the
               historical and current business operations, financial conditions
               and prospects of the Company and the Parent and such other
               matters we deemed relevant;
 
                   (v) the reported price and trading histories of the shares of
               Company Common Stock and Parent Common Stock as compared to the
               reported price and trading histories of certain publicly traded
               companies we deemed relevant;
 
                                         B-2
<PAGE>
      Board of Directors
      Arterial Vascular Engineering, Inc.
      November 29, 1998
      Page 3 of 4
 
                   (vi) First Call consensus earnings per share estimates of
               financial institutions (the "First Call Estimates") for the
               Company and the Parent, respectively, and financial projections
               provided in currently available Wall Street analyst reports (the
               "Analyst Projections") for the Company and the Parent,
               respectively, including, among other things, the capital
               structure, sales, net income, cash flow, capital requirements and
               other data of the Company and the Parent we deemed relevant;
 
                   (vii) discussions with management and senior personnel of the
               Company and the Parent concerning the First Call Estimates and
               Analyst Projections;
 
                   (viii) based on the Analyst Projections, the potential pro
               forma financial effects of the Merger;
 
                   (ix) certain aspects of the respective financial conditions
               of the Company and the Parent as compared to such aspects of the
               financial conditions of certain other companies we deemed
               relevant;
 
                   (x) certain financial terms of the Merger as compared to the
               financial terms of selected other business combinations we deemed
               relevant; and
 
                   (xi) such other information, financial studies, analyses and
               investigations and such other factors that we deemed relevant for
               the purposes of this opinion.
 
               In conducting our review and arriving at our opinion, we have,
           with your consent, assumed and relied, without independent
           investigation, upon the accuracy and completeness of all financial
           and other information provided to us by the Company and the Parent or
           which is publicly available, and we have not undertaken any
           responsibility for the accuracy, completeness or reasonableness of,
           or independently verified, such information. In addition, we have not
           assumed any obligation to conduct any physical inspection of the
           properties or facilities of the Company or the Parent. We have
           further relied upon the assurance of management of the Company that
           they are unaware of any facts that would make the information so
           provided to us by the Company or the Parent or which is publicly
           available (including, without limitation, the First Call Estimates
           and Analyst Projections) incomplete or misleading in any respect.
           With your consent, we have assumed that the First Call Estimates and
           Analyst Projections reviewed by us provide a reasonable basis for our
           opinion and indicate reasonable estimates of the future performance
           of the Company and the Parent, and we have relied upon such estimates
           and projections. We have not made or obtained any independent
           evaluations, valuations or appraisals of the assets or liabilities of
           the Company or the Parent, nor have we been furnished with any such
           materials. With respect to all legal matters relating to the Company
           and the Parent, we have relied on the advice of legal counsel to the
           Company. You have informed us, and we have assumed, that the Merger
           (i) will be recorded as a pooling-of-interests under generally
           accepted accounting principles and (ii) will be treated as a tax-free
           reorganization within the meaning of Section 368(a) of the Internal
           Revenue Code of 1986, as amended.
 
               Our opinion is necessarily based upon economic and market
           conditions and other circumstances as they exist and can be evaluated
           by us on the date hereof. It should be understood that although
           subsequent developments may affect our opinion, we do not have any
           obligation to update, revise or reaffirm our opinion and we expressly
           disclaim any responsibility to do so. Without limiting the generality
           of the foregoing, we are not opining as
 
                                         B-3
<PAGE>
      Board of Directors
      Arterial Vascular Engineering, Inc.
      November 29, 1998
      Page 4 of 4
           to the effect of the consummation of, or the failure to consummate,
           the acquisition of Sofamor Danek Group, Inc. by the Parent.
           Additionally, we have not been authorized or requested to, and did
           not, solicit alternative offers for the Company or its assets.
 
               For purposes of rendering our opinion we have assumed, in all
           respects material to our analysis, that the representations and
           warranties of each party contained in the Transaction Agreement are
           true and correct, that each party will perform all of the covenants
           and agreements required to be performed by it under the Transaction
           Agreement and that all conditions to the consummation of the Merger
           will be satisfied without waiver thereof. We also have assumed that
           all governmental, regulatory and other consents and approvals
           contemplated by the Transaction Agreement will be obtained, and that
           in the course of obtaining any of those consents no restrictions will
           be imposed or waivers made that would have an adverse effect on the
           contemplated benefits of the Merger.
 
               It is understood that this letter is intended for the benefit and
           use of the Board of Directors of the Company in its consideration of
           the Merger and may not be used for any other purpose or reproduced,
           disseminated, quoted or referred to at any time, in any manner or for
           any purpose without our prior written consent, provided, however,
           that this letter may be reproduced in its entirety in any proxy
           statement or registration statement relating to the Merger filed by
           the Company or the Parent under the Securities Exchange Act of 1934,
           as amended, or the Securities Act of 1933, as amended (the
           "Securities Act"), and distributed to stockholders of the Company in
           accordance therewith, provided that it will be reproduced in such
           proxy statement or registration statement in full, and any
           description of or reference to SG Cowen or summary of this letter in
           such proxy statement or registration statement will be in a form
           acceptable to SG Cowen and its counsel, and provided further that, in
           consenting to such inclusion, we do not admit or acknowledge that we
           come within the category of persons whose consent is required under
           Section 7 of the Securities Act or the rules and regulations
           promulgated thereunder. This letter does not constitute a
           recommendation to any stockholder as to how such stockholder should
           vote with respect to the Merger or to take any other action in
           connection with the Merger or otherwise. We have not been requested
           to opine as to, and our opinion does not in any manner address, the
           Company's underlying business decision to effect the Merger. We are
           not expressing any opinion as to what the value of the Parent Common
           Stock actually will be when issued to the Company's stockholders
           pursuant to the Merger. Furthermore, we express no view as to the
           price or trading range for shares of Company Common Stock or Parent
           Common Stock following consummation of the Merger or otherwise.
 
               Based upon and subject to the foregoing, including the various
           assumptions and limitations set forth herein, it is our opinion that,
           as of the date hereof, the Conversion Ratio is fair, from a financial
           point of view, to the stockholders of the Company.
 
                                               Very truly yours,
 
                                               /s/ SG COWEN SECURITIES
                                               CORPORATION
 
                                               SG COWEN SECURITIES CORPORATION
 
                                         B-4
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 20. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
 
    Minnesota Statutes Section 302A.521, subd. 2, requires Medtronic to
indemnify a person made or threatened to be made a party to a proceeding by
reason of the former or present official capacity of the person with respect to
Medtronic, against judgments, penalties, fines, settlements, and reasonable
expenses, including attorneys' fees and disbursements, incurred by the person in
connection with the proceeding if certain statutory standards are met. In
addition, Section 302A.521, subd. 3, requires payment by Medtronic, upon written
request, of reasonable expenses in advance of final disposition of the
proceeding in certain circumstances. A decision as to required indemnification
is made by a disinterested majority of the Board of Directors present at a
meeting at which a disinterested quorum is present, or by a designated committee
of the Board, by special legal counsel, by the shareholders, or by a court.
Section 302A.521 contains detailed terms regarding such right of indemnification
and reference is made thereto for a complete statement of such indemnification
rights.
 
    Medtronic's Bylaws provide for indemnification by Medtronic to the full
extent permitted by Minnesota Statutes Section 302A.521, as now enacted or
hereafter amended, against and with respect to threatened, pending, or completed
actions, suits, or proceedings arising from, or alleged to arise from, a party's
actions or omissions as a director, officer, employee, or agent of Medtronic or
any subsidiary of Medtronic or of any other corporation, partnership, joint
venture, trust, or other enterprise that has served in such capacity at the
request of Medtronic if such acts or omissions occurred, or were or are alleged
to have occurred, while such party was a director or officer of Medtronic.
Generally, under Minnesota law, indemnification will be available only where an
officer or director can establish that he or she acted in good faith and in a
manner such person reasonably believed to be in or not opposed to the best
interests of Medtronic. As permitted by Minnesota Statutes Section 302A.521,
Medtronic's Restated Articles of Incorporation provide that a director shall
have no personal liability to Medtronic or its shareholders for breach of his or
her fiduciary duty as a director, to the fullest extent permitted by law.
 
    In addition to providing indemnification as outlined above, Medtronic also
purchases individual insurance coverage for its directors and officers. Subject
to the stated conditions, the policy insures the directors and officers of
Medtronic against liability arising out of actions taken in their official
capacities. To the extent that such actions cannot be indemnified by Medtronic,
the policy provides individual liability insurance protection for the directors
and officers of Medtronic.
 
ITEM 21. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
 
(a) Exhibits
 
<TABLE>
<C>        <S>
       2   Agreement and Plan of Merger, dated November 29, 1998, by and among Medtronic, Inc.,
             Arterial Vascular Engineering, Inc., and MAV Merger Corp., including the Exhibits
             thereto. (The Agreement and Plan of Merger is furnished as Annex A to the Proxy
             Statement/ Prospectus forming a part of this Registration Statement.) Upon the
             request of the Commission, Medtronic agrees to furnish supplementally to the
             Commission a copy of any disclosure schedules to the Agreement and Plan of Merger.
 
       5   Opinion and Consent of Fredrikson & Byron, P.A. regarding validity of shares.
 
      8.1  Opinion and Consent of Cooley Godward LLP regarding certain tax matters.
 
      8.2  Opinion and Consent of Fredrikson & Byron, P.A. regarding certain tax matters.
 
     23.1  Consent of Fredrikson & Byron, P.A. (included in Exhibits 5 and 8.2).
 
     23.2  Consent of Cooley Godward LLP regarding certain tax matters (included in Exhibit 8.1).
</TABLE>
 
                                      II-1
<PAGE>
<TABLE>
<C>        <S>
     23.3  Consent of PricewaterhouseCoopers LLP, independent accountants for Medtronic, Inc.
 
     23.4  Consent of Ernst & Young LLP, independent auditors for Arterial Vascular Engineering,
             Inc.
 
     23.5  Consent of Arthur Andersen LLP, independent public accountants for C.R. Bard, Inc.
             Cardiology Division--Coronary Catheter Lab Products.
 
     23.6  Consent of SG Cowen Securities Corporation.
 
      24   Power of Attorney.
 
     99.1  Form of Proxy to be used by Arterial Vascular Engineering, Inc. shareholders.
 
(b)        Financial Statement Schedules.
 
           Not applicable.
 
     (c)   Reports, Opinions and Appraisals Materially Related to the Transaction.
 
           Opinion of SG Cowen Securities Corporation is furnished as Annex B to the Proxy
           Statement/ Prospectus forming a part of this Registration Statement.
</TABLE>
 
ITEM 22. UNDERTAKINGS.
 
    (a) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
 
    (b) (i) The undersigned registrant hereby undertakes as follows: that prior
to any public reoffering of the securities registered hereunder through use of a
prospectus which is a part of this registration statement, by any person or
party who is deemed to be an underwriter within the meaning of Rule 145(c), the
issuer undertakes that such reoffering prospectus will contain the information
called for by the applicable registration form with respect to reofferings by
persons who may be deemed underwriters, in addition to the information called
for by the other Items of the applicable form.
 
        (ii) The registrant undertakes that every prospectus [a] that is filed
pursuant to paragraph (b)(i) immediately preceding, or [b] that purports to meet
the requirements of Section 10(a)(3) of the Securities Act and is used in
connection with an offering of securities subject to Rule 415, will be filed as
a part of an amendment to the registration statement and will not be used until
such amendment is effective, and that, for purposes of determining any liability
under the Securities Act of 1933, each such post-effective amendment shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
 
    (c) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.
 
                                      II-2
<PAGE>
    (d) The undersigned registrant hereby undertakes to respond to requests for
information that is incorporated by reference into the prospectus pursuant to
Items 4, 10(b), 11, or 13 of this Form, within one business day of receipt of
such request, and to send the incorporated documents by first class mail or
other equally prompt means. This includes information contained in documents
filed subsequent to the effective date of the registration statement through the
date of responding to the request.
 
    (e) The undersigned registrant hereby undertakes to supply by means of a
post-effective amendment all information concerning a transaction, and the
company being acquired involved therein, that was not the subject of and
included in the registration statement when it became effective.
 
                                      II-3
<PAGE>
                                   SIGNATURES
 
    Pursuant to the requirements of the Securities Act of 1933, the Registrant
has duly caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Minneapolis, State of
Minnesota, on December 18, 1998.
 
<TABLE>
<S>                             <C>  <C>
                                MEDTRONIC, INC.
 
                                By             /s/ WILLIAM W. GEORGE
                                     ------------------------------------------
                                                 William W. George,
                                        Chairman and Chief Executive Officer
</TABLE>
 
                                      II-4
<PAGE>
    Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed on December 18, 1998 by the following
persons in the capacities indicated.
 
<TABLE>
<CAPTION>
          SIGNATURE                       TITLE
- ------------------------------  --------------------------
<C>                             <S>                         <C><C>
                                Chairman, Chief Executive
    /s/ WILLIAM W. GEORGE         Officer and Director
 ----------------------------     (principal executive
      William W. George           officer)
 
                                Senior Vice President and
      /s/ ROBERT L. RYAN          Chief Financial Officer
 ----------------------------     (principal financial and
        Robert L. Ryan            accounting officer)
 
              *
 ----------------------------   Vice Chairman and Director
     Glen D. Nelson, M.D.
 
              *
 ----------------------------   Director
William R. Brody, M.D., Ph.D.
 
              *
 ----------------------------   Director
      Paul W. Chellgren
 
              *
 ----------------------------   Director
    Arthur D. Collins, Jr.
 
              *
 ----------------------------   Director
 Antonio M. Gotto, Jr., M.D.
 
              *
 ----------------------------   Director
   Bernadine P. Healy, M.D.
 
              *
 ----------------------------   Director
      Thomas E. Holloran
                                                            *By /s/ RONALD E. LUND
                                                               ------------------------
                                                               Ronald E. Lund
                                                               Attorney-in-Fact
 
              *
 ----------------------------   Director
      Jean-Pierre Rosso
 
              *
 ----------------------------   Director
      Richard L. Schall
 
              *
 ----------------------------   Director
       Jack W. Schuler
 
              *
 ----------------------------   Director
      Gerald W. Simonson
 
              *
 ----------------------------   Director
      Gordon M. Sprenger
 
              *
 ----------------------------   Director
   Richard A. Swalin, Ph.D.
</TABLE>
 
                                      II-5
<PAGE>
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
 
                            ------------------------
 
                                 EXHIBIT INDEX
                                       TO
                        FORM S-4 REGISTRATION STATEMENT
 
                            ------------------------
 
- --------------------------------------------------------------------------------
 
                                MEDTRONIC, INC.
 
- --------------------------------------------------------------------------------
 
<TABLE>
<CAPTION>
  EXHIBIT    DESCRIPTION
- -----------  ------------------------------------------------------------------------------------------------
<C>          <S>                                                                                               <C>
       2     Agreement and Plan of Merger, dated November 29, 1998, by and among Medtronic, Inc., AVE Group,
             Inc., and MAV Merger Corp., including the Exhibits thereto (The Agreement and Plan of Merger is
             furnished as Annex A to the Proxy Statement/Prospectus forming a part of this Registration
             Statement.)
 
       5     Opinion and Consent of Fredrikson & Byron, P.A. regarding validity of shares
 
       8.1   Opinion and Consent of Cooley Godward LLP regarding certain tax matters
 
       8.2   Opinion and Consent of Fredrikson & Byron, P.A. regarding certain tax matters
 
      23.1   Consent of Fredrikson & Byron, P.A. (included in Exhibits 5 and 8.2)
 
      23.2   Consent of Cooley Godward LLP regarding certain tax matters (included in Exhibit 8.1)
 
      23.3   Consent of PricewaterhouseCoopers LLP, independent accountants for Medtronic, Inc.
 
      23.4   Consent of Ernst & Young LLP, independent auditors for Arterial Vascular Engineering, Inc.
 
      23.5   Consent of Arthur Andersen LLP, independent public accountants for C.R. Bard, Inc. Cardiology
             Division--Coronary Catheter Lab Products.
 
      23.6   Consent of SG Cowen Securities Corporation
 
      24     Power of Attorney of certain officers and directors
 
      99.1   Form of Proxy to be used by Arterial Vascular Engineering, Inc. shareholders
</TABLE>

<PAGE>

                                                                      EXHIBIT A

                 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                                         OF
                        ARTERIAL VASCULAR ENGINEERING, INC.


     The following Amended and Restated Certificate of Incorporation of Arterial
Vascular Engineering, Inc., originally incorporated in Delaware on July 30, 1994
under the name "Applied Vascular Engineering, Inc.," has been duly adopted in
accordance with the provisions of the Delaware General Corporation Law:

                                  ARTICLE 1 - NAME

     The name of the corporation shall be Medtronic Arterial Vascular
Engineering, Inc.


                      ARTICLE 2 - REGISTERED OFFICE AND AGENT

     The registered office of the corporation in the State of Delaware is 1209
Orange Street, in the City of Wilmington, County of Newcastle, Delaware, 19801.
The name of its registered agent at such address is The Corporation Trust
Company.


                                ARTICLE 3 - PURPOSES

     The nature of the business or purposes to be conducted or promoted by the
corporation is to engage in any lawful acts and activities for which
corporations may be organized under the General Corporation Law of Delaware.


                                 ARTICLE 4 - STOCK

     The aggregate number of shares the corporation has authority to issue shall
be 2,500 shares of Common Stock, $.01 par value.  Holders of Common Stock shall
be entitled to one vote for each share of Common Stock held of record.


                         ARTICLE 5 - RIGHTS OF STOCKHOLDERS

     5.1)  NO PREEMPTIVE RIGHTS.  No holder of shares of the corporation of any
class now or hereafter authorized has any preferential or preemptive right to
subscribe for, purchase or receive any shares of the corporation of any class
now or hereafter authorized, or any options or warrants for such shares, which
may at any time be issued, sold or offered for sale by the corporation.

     5.2)  NO CUMULATIVE VOTING RIGHTS.  No holder of shares of the corporation
of any class now or hereafter authorized shall be entitled to cumulative voting.


<PAGE>

                           ARTICLE 6 - MEETINGS AND BOOKS

     6.1)  MEETINGS OF STOCKHOLDERS AND ELECTION OF DIRECTORS.  Meetings of
stockholders may be held within or outside the State of Delaware, as the Bylaws
may provide.  Elections of directors need not be by written ballot unless and
except to the extent that the Bylaws so provide.

     6.2)  CORPORATE BOOKS.  The books of the corporation may be kept within or
(subject to any provision contained in the statutes) outside the State of
Delaware at such place or places as may be designated from time to time by the
Board of Directors or in the Bylaws of the corporation.


                    ARTICLE 7 - LIMITATION OF DIRECTOR LIABILITY

     7.1)  LIMITATION OF LIABILITY.  A director of the corporation shall not be
personally liable to the corporation or its stockholders for monetary damages
for any breach of fiduciary duty as a director, except for liability (i) for any
breach of the director's duty of loyalty to the corporation or its stockholders,
(ii) for acts or omissions not in good faith or which involve intentional
misconduct or a knowing violation of law, (iii) under Section 174 of the
Delaware General Corporation Law, or (iv) for any transaction from which the
director derived an improper personal benefit.  If the Delaware General
Corporation Law is amended after approval by the stockholders of this Article to
authorize corporate action further eliminating or limiting the personal
liability of directors, then the liability of a director shall be eliminated or
limited to the fullest extent permitted by the Delaware General Corporation Law,
as so amended.

     7.2)  AMENDMENT OF THIS ARTICLE.  Any repeal or modification of this
Article 7 shall be prospective and shall not affect the rights under this
Article 7 in effect at the time of the alleged occurrence of any act or omission
to act giving rise to liability or indemnification.


                                 ARTICLE 8 - BYLAWS

     The Board of Directors is expressly authorized to make and alter Bylaws of
this corporation, subject to the power of the stockholders to change or repeal
such Bylaws and subject to any other limitations on such authority provided by
the General Corporation Law of Delaware.


                                          2
<PAGE>


                                                                       EXHIBIT B
                                 AFFILIATE'S LETTER


Medtronic, Inc.
7000 Central Avenue N.E.
Minneapolis, MN 55432

Ladies and Gentlemen:

The undersigned officer and/or director of Arterial Vascular Engineering, Inc.
(the "Company") has been advised that the undersigned may be deemed by the
Company to be an "affiliate" of the Company, as that term is used in paragraphs
(c) and (d) of Rule 145 under the Securities Act of 1933, as amended (the
"Securities Act") (such rule, as amended or replaced by any successor rule,
referred to herein as "Rule 145") and for purposes of Accounting Series Releases
130 and 135, as amended, of the Securities and Exchange Commission (the "SEC").
Pursuant to the terms of the Agreement and Plan of Merger dated on or about
November 29, 1998 (the "Merger Agreement"), among Medtronic, Inc. ("Parent"),
MAV Merger Corp. ("Merger Subsidiary"), and the Company, Merger Subsidiary will
be merged with and into the Company (the "Merger").  As a result of the Merger,
outstanding shares of common stock, $.001 par value, of the Company ("Company
Common Stock") will be converted into the right to receive shares of common
stock, $.10 par value per share, of Parent ("Parent Common Stock"), as
determined pursuant to the Merger Agreement.

In order to induce Parent and the Company to enter into the Merger Agreement and
to consummate the Merger, the undersigned (referred to herein as "Affiliate")
represents, warrants and agrees as follows:

1.   Affiliate will not sell, transfer, pledge, dispose of, or otherwise reduce
     Affiliate's risk relative to, any Parent Common Stock or Company Common
     Stock during the period commencing 30 days prior to the effective time of
     the Merger and ending at such time as financial results covering at least
     30 days of the post-Merger combined operations of Parent and the Company
     have been published by Parent, in the form of a quarterly earnings report,
     an effective registration statement filed with the SEC, a report to the SEC
     on Form 10-K, 10-Q or 8-K, or any other public filing or announcement which
     includes the combined results of operations.  If Affiliate proposes to
     sell, transfer, pledge, dispose of, or otherwise reduce Affiliate's risk
     relative to, any Parent Common Stock or Company Common Stock during such
     period, Affiliate shall give Parent and the Company written notice of the
     terms and conditions of such proposed sale, transfer, pledge, disposal, or
     other reduction of Affiliate's risk, and shall not effect such proposed
     sale, transfer, pledge, disposal, or other reduction of Affiliate's risk
     unless and until Affiliate has received the written consent of Parent,
     which consent shall not be unreasonably withheld or delayed unless Parent's
     or the Company's independent auditors reasonably determine that such
     proposed sale, transfer, pledge, disposal, or other reduction of
     Affiliate's risk could adversely affect Parent's ability to account for the
     Merger as a pooling of interests.


                                         -1-
<PAGE>

2.   Affiliate has been advised that the issuance of the Parent Common Stock, if
     any, to Affiliate pursuant to the Merger is being registered with the SEC
     under the Securities Act and the rules and regulations promulgated
     thereunder on a Registration Statement on Form S-4.  However, Affiliate has
     also been advised that, because Affiliate may be deemed to be an
     "affiliate" of the Company (as that term is used in paragraphs (c) and (d)
     of Rule 145), any sale, transfer or other disposition by Affiliate of any
     Parent Common Stock issued pursuant to the Merger will, under current law,
     require either (a) further registration under the Securities Act of the
     Parent Common Stock to be sold, transferred, or otherwise disposed of, or
     (b) compliance with Rule 145, or (c) the availability of another exemption
     from such registration.

3.   Affiliate will not offer to sell, sell, or otherwise dispose of any Parent
     Common Stock issued pursuant to the Merger except pursuant to an effective
     registration statement or in compliance with Rule 145 or another exemption
     from the registration requirements of the Securities Act (the compliance
     with Rule 145 or the availability of such other exemption to be established
     by Affiliate to the reasonable satisfaction of Parent's counsel).

4.   Affiliate consents to the placement of a stop transfer order with the
     Company's and Parent's stock transfer agent and registrar, and to the
     placement of the following legend on certificates representing the Parent
     Common Stock issued or to be issued to Affiliate:

          "THE SHARES REPRESENTED BY THIS CERTIFICATE MAY NOT BE SOLD OR
          OTHERWISE TRANSFERRED EXCEPT IN COMPLIANCE WITH AN AFFILIATE'S LETTER
          FROM THE UNDERSIGNED TO MEDTRONIC, INC., AND PURSUANT TO AN EFFECTIVE
          REGISTRATION STATEMENT OR IN COMPLIANCE WITH RULE 145 OF THE
          SECURITIES ACT OF 1933 OR ANOTHER EXEMPTION FROM THE REGISTRATION
          REQUIREMENTS OF THE SECURITIES ACT OF 1933."

5.   Affiliate has carefully read this letter and has discussed with counsel for
     Affiliate or counsel for the Company, to the extent Affiliate felt
     necessary, the requirements of this letter and other applicable limitations
     on the ability of Affiliate to sell, transfer, or otherwise dispose of
     Company Common Stock and Parent Common Stock.

6.   The Company agrees to take all reasonable actions up to the date of the
     Merger, including but not limited to the placement of a stop transfer order
     with the Company's stock transfer agent and registrar, to ensure compliance
     by Affiliate with the provisions of this letter.

7.   Execution of this letter should not be considered an admission on the part
     of Affiliate that Affiliate is an "affiliate" of the Company as described
     in the first paragraph of this letter, nor as a waiver of any rights that
     Affiliate may have to object to any claim that Affiliate is such an
     affiliate on or after the date of this letter.


                                         -2-
<PAGE>

8.   By Parent's acceptance of this letter, Parent hereby agrees with Affiliate
as follows:

     (A)  For so long as and to the extent necessary to permit Affiliate to sell
          Parent Common Stock pursuant to Rule 145 and, to the extent
          applicable, Rule 144 under the Securities Act, Parent shall (a) use
          its reasonable efforts to (i) file, on a timely basis, all reports and
          data required to be filed with the SEC by it pursuant to Section 13 of
          the Securities Exchange Act of 1934, as amended (the "1934 Act"), and
          (ii) furnish to Affiliate upon request a written statement as to
          whether Parent has complied with such reporting requirements during
          the 12 months preceding any proposed sale of Parent Common Stock by
          Affiliate under Rule 145, and (b) otherwise use its reasonable efforts
          in permit such sales pursuant to Rule 145 and Rule 144.  Parent hereby
          represents to Affiliate that it has filed all reports required to be
          filed with the SEC under Section 13 of the 1934 Act during the
          preceding 12 months.

     (B)  It is understood and agreed that certificates with the legends set
          forth in paragraph 4 above will be substituted by delivery of
          certificates without such legends if (i) one year shall have elapsed
          from the date the undersigned acquired the Parent Common Stock
          received in the Merger and the provisions of Rule 145(d)(2) are then
          available to the undersigned, (ii) two years shall have elapsed from
          the date the undersigned acquired the Parent Common Stock received in
          the Merger and the provisions of Rule 145(d)(3) are then applicable to
          the undersigned, or (iii) Parent has received either an opinion of
          counsel, which opinion and counsel shall be reasonably satisfactory to
          Parent, or a "no action" letter obtained by the undersigned from the
          staff of the SEC, to the effect that the restrictions imposed by Rule
          145 under the Act no longer apply to the undersigned.

9.   Notwithstanding any other provision contained herein, this Affiliate's
Letter and all obligations of and restrictions imposed on Affiliate hereunder,
and all obligations imposed on the Company hereunder, shall terminate upon the
termination of the Merger Agreement in accordance with its terms; provided that
such termination shall not relieve Affiliate of liability for any prior breach
of Affiliate's obligations hereunder.

                                        Very truly yours,


                , 1998
- ----------------                        ----------------------------------------
                                        (Signature)


                                        ----------------------------------------
                                        (Name) (Please Print)

                                        ARTERIAL VASCULAR ENGINEERING, INC.


                                        By:
                                           -------------------------------------
                                           Its:
                                               ---------------------------------


                                         -3-
<PAGE>


                                     ACCEPTANCE

     Medtronic, Inc. hereby accepts the foregoing Affiliate's Letter delivered
pursuant to Section 5.7 of the Agreement and Plan of Merger dated November 29,
1998, by and among Medtronic, Inc., MAV Merger Corp., and Arterial Vascular
Engineering, Inc.


                                        MEDTRONIC, INC.


                                        By:
                                           -------------------------------------
                                        Michael D. Ellwein, Vice President and
                                        Chief Development Officer


                                         -4-
<PAGE>


                                                                       EXHIBIT C

                            AGREEMENT TO FACILITATE MERGER

DATE:     ____________, 1998

PARTIES:

          Medtronic, Inc.,                           (hereinafter "Parent")
          a Minnesota corporation

               and

          ____________________________,
          an individual officer and/or director
          of Arterial Vascular Engineering, Inc.     (hereinafter "Stockholder")

RECITALS:

     A.   Stockholder is the legal or beneficial owner of  shares of Common
Stock of Arterial Vascular Engineering, Inc., a Delaware corporation (the
"Company"), and the holder of options, warrants, or other rights to acquire
shares of Company Common Stock.

     B.   Parent, the Company, and a wholly-owned subsidiary of Parent are
entering, or have entered, into an Agreement and Plan of Merger (the "Merger
Agreement") pursuant to which it is proposed that Parent's subsidiary will merge
with and into the Company (the "Merger") and as a result of which the
outstanding shares of Company Common Stock shall be converted into Parent Common
Stock.

     C.   Stockholder deems it to be in Stockholder's best interest and in the
best interests of the Company and all other stockholders of the Company that the
Merger Agreement be approved, ratified, and confirmed by the stockholders of the
Company, and it is a condition to Parent's execution of the Merger Agreement
that Stockholder enter into this Agreement.

     D.   It is understood and acknowledged by Stockholder that Parent's
execution of the Merger Agreement is being done in reliance, in part, upon the
contemporaneous or prompt subsequent execution and delivery of this Agreement,
that Parent will incur substantial expenses proceeding toward consummation of
the Merger as contemplated by the Merger Agreement, and that such expenses will
be undertaken, in part, in reliance upon and as a result of the agreements and
undertakings of Stockholder set forth herein.

     NOW, THEREFORE, in consideration of the foregoing, and in order to induce
Parent to execute the Merger Agreement and to proceed as contemplated by the
Merger Agreement toward the consummation of the Merger, and for other good and
valuable consideration, the receipt and adequacy of which is hereby
acknowledged, the parties hereto agree as follows:


                                         -1-
<PAGE>

AGREEMENTS:

     1.   VOTE IN FAVOR OF MERGER.  During the period commencing on the date
hereof and terminating upon the earlier of the effective time of the Merger or
the termination of the Merger Agreement in accordance with its terms,
Stockholder, solely in his or her capacity as a stockholder of the Company
agrees to vote (or caused to be voted) all outstanding shares of Company Common
Stock beneficially owned by Stockholder as of the record date of any meeting of
the stockholders of the Company, and as of the record date of any action by
written consent of the stockholders of the Company, in favor of the approval,
consent, and ratification of the Merger Agreement and the Merger.  To the extent
inconsistent with the foregoing provisions of this Section 1, Stockholder hereby
revokes any and all previous proxies with respect to any shares of Company
Common Stock that Stockholder owns or has the right to vote.  Nothing in this
Agreement shall be deemed to restrict or limit Stockholder's right to act in his
capacity as an officer or director of the Company consistent with his fiduciary
obligations in such capacity.

     2.   REPRESENTATIONS AND WARRANTIES OF STOCKHOLDER.  Stockholder represents
and warrants to Parent that Stockholder has the legal capacity to enter into and
perform all of Stockholder's obligations under this Agreement.  The execution,
delivery, and performance of this Agreement by Stockholder will not violate any
other agreement to which Stockholder is a party, including, without limitation,
any voting agreement, stockholders agreement, or voting trust.  This Agreement
has been duly executed and delivered by Stockholder and constitutes a legal,
valid, and binding agreement of Stockholder, enforceable in accordance with its
terms, except as the enforcement thereof may be limited by bankruptcy,
insolvency, fraudulent conveyance, reorganization, moratorium, and similar laws,
now or hereafter in effect.

     3.   SUCCESSORS AND ASSIGNS.  This Agreement shall be binding upon any
permitted purchasers, donees, pledgees, and other transferees of Company Common
Stock legally or beneficially owned by Stockholder. During the period commencing
on the date hereof and terminating upon the earlier of the effective time of the
Merger or the termination of the Merger Agreement in accordance with its terms,
Stockholder agrees not to make any sales, gifts, transfers, pledges, or other
dispositions of Company Common Stock without first making any such transferee or
pledgee fully aware of the obligations under this Agreement and obtaining such
transferee's or pledgee's written agreement to comply with the terms hereof.

     4.   INJUNCTIVE RELIEF.  Stockholder agrees that in the event of
Stockholder's breach of any provision of this Agreement, Parent may be without
an adequate remedy at law.  Stockholder therefore agrees that in the event of
Stockholder's breach of any provision of this Agreement, Parent may elect to
institute and prosecute proceedings in any court of competent jurisdiction to
enforce specific performance or to enjoin the continuing breach of such
provision, as well as to obtain damages for breach of this Agreement.  By
seeking or obtaining any such relief, Parent will not be precluded from seeking
or obtaining any other relief to which it may be entitled.

     5.   COUNTERPARTS.  This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original and all of which
together shall constitute one and the same document.


                                         -2-
<PAGE>

     6.   FURTHER ASSURANCES.  Stockholder shall (at Parent's expense) execute
and deliver such additional documents and take such further action as may be
reasonably requested by Parent to enforce Parent's rights under this Agreement.

     7.   THIRD-PARTY BENEFICIARIES.  Nothing in this Agreement, expressed or
implied, shall be construed to give any person other than the parties hereto any
legal or equitable right, remedy, or claim under or by reason of this Agreement
or any provision contained herein.

     8.   GOVERNING LAW.  This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware (regardless of the laws that
might otherwise govern under applicable Delaware principles of conflicts of
laws).

     9.   EFFECTIVENESS.  If this Agreement is executed by Stockholder prior to
the approval of the Merger Agreement by the Company's Board of Directors, then
this Agreement shall be subject to, and shall become effective only upon, the
approval of the Merger Agreement by the Company's Board of Directors and the
execution and delivery of the Merger Agreement by the Company, Parent and
Parent's subsidiary.  This Agreement shall terminate upon the earlier of (i)
termination of the Merger Agreement in accordance with its terms, or (ii)
effectiveness of the Merger.

     IN WITNESS WHEREOF, Parent has caused this Agreement to Facilitate Merger
to be executed by its duly authorized officer, and Stockholder has executed this
Agreement, as of the date and year first above written.


                                       -----------------------------------
                                       [Signature]


                                       -----------------------------------
                                       [Print Name]


                                       MEDTRONIC, INC.


                                       By:
                                          --------------------------------
                                          Michael D. Ellwein, Vice President and
                                          Chief Development Officer


                                         -3-
<PAGE>


                                                                       EXHIBIT D
                               STOCK OPTION AGREEMENT


     THIS AGREEMENT is dated as of November 29, 1998, between Medtronic, Inc., a
Minnesota corporation ("Grantee"), and Arterial Vascular Engineering, Inc., a
Delaware corporation ("Issuer").

                                      RECITALS

     A.   Grantee, Issuer, and MAV Merger Corp., a Delaware corporation and
wholly-owned subsidiary of Grantee ("Merger Subsidiary"), are entering into an
Agreement and Plan of Merger (the "Merger Agreement") which provides, among
other things, that, upon the terms and subject to the conditions thereof, Merger
Subsidiary will be merged with and into Issuer (the "Merger").

     B.   As a condition to its willingness to enter into the Merger Agreement,
Grantee has required that Issuer enter into this Agreement, which provides,
among other things, that Issuer grant to Grantee an option to purchase shares of
Issuer's Common Stock, $.001 par value ("Issuer Common Stock"), upon the terms
and subject to the conditions provided for herein.

     NOW, THEREFORE, in consideration of the premises and mutual covenants and
agreements contained in this Agreement and the Merger Agreement, the parties
agree as follows:

     1.   GRANT OF OPTION.  Subject to the terms and conditions of this
Agreement, Issuer hereby grants to Grantee an irrevocable option (the "Option")
to purchase 12,807,795 shares of Issuer Common Stock (the "Option Shares"), in
the manner set forth below, at an exercise price of $54.00 per share of Issuer
Common Stock, subject to adjustment as provided below (the "Option Price").
Issuer represents that the Option Shares represent at least 19.9% of the number
of shares of Issuer Common Stock outstanding on the date hereof.  Capitalized
terms used herein but not defined herein shall have the meanings set forth in
the Merger Agreement.

     2.   EXERCISE OF OPTION.

          (a)  Subject to the terms and conditions of this Agreement, Grantee or
     its designee (which shall be a wholly-owned subsidiary of Grantee) may,
     prior to the Expiration Date (as defined in Section 12 hereof), exercise
     the Option, in whole or in part, at any time or from time to time on or
     after the occurrence of an Exercise Event (as defined below).  As used
     herein, an "Exercise Event" shall mean (i) the occurrence of a termination
     specified in Section 7.2(a)(i) of the Merger Agreement or (ii) the
     occurrence of all of the events and circumstances specified in clauses (A),
     (B) and (C) of Section 7.2(a)(ii) of the Merger Agreement; provided,
     however, that notwithstanding anything to the contrary contained in this
     Agreement, if the Option becomes exercisable as a result of the Exercise
     Event referred to in Section 2(a)(ii) hereof, Grantee shall not be entitled
     to exercise the cancellation right referred to below in this Section 2(a)
     unless and until all of


                                         -1-
<PAGE>

     the events and circumstances specified in clauses (A), (B), (C) and (D) of
     Section 7.2(a)(ii) of the Merger Agreement shall have occurred.

          (b)  In the event Grantee wishes to exercise the Option at such time
     as the Option is exercisable, Grantee shall deliver written notice (the
     "Exercise Notice") to Issuer exercising the Option and specifying the total
     number of Option Shares it wishes to purchase, and a date and time for the
     closing of such purchase (a "Closing") not less than five nor more than 30
     business days after the later of (i) the date such Exercise Notice is given
     and (ii) the expiration or termination of any applicable waiting period
     under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended
     (the "HSR Act").  Subject to the proviso at the end of Section 2(a) hereof,
     when this Option is exercisable, Grantee, in lieu of exercising the Option,
     shall have the right at any time thereafter prior to the Expiration Date to
     request in writing that Issuer pay, and promptly (but in any event not more
     than five business days) after Grantee makes such request, Issuer shall,
     subject to Section 2(c) below, pay to Grantee by certified check, official
     bank check or wire transfer pursuant to Grantee's instructions, in
     cancellation of the Option, an amount in cash (the "Cancellation Amount")
     equal to (i) the greater of

               (x)  the excess, if any,  over the Option Price of the greater of
          (A) the last sale price of a share of Issuer Common Stock as reported
          on the Nasdaq National Market (or other United State national exchange
          upon which Issuer's Common Stock is traded) on the last trading day
          prior to the date of the Exercise Notice, (B) the highest price per
          share of Issuer Common Stock offered to be paid or paid in connection
          with any Alternative Transaction occurring after the date hereof and
          prior to the Expiration Date, and (C) in the case of any Alternative
          Transaction structured as an asset acquisition, the highest net
          consideration to be distributed to the stockholders of the Company in
          any such transaction or proposed transaction occurring after the date
          hereof and prior to the Expiration Date after, among any other
          payments and deductions, payment of all indebtedness of the Company
          not being assumed, divided by the number of shares of Issuer Common
          Stock outstanding on a fully diluted basis, and

               (y)  $150,000,000 divided by the initial number of Option Shares
          covered by the Option,

     multiplied by (ii) the number of Option Shares then covered by the Option;
     provided, however, that the Cancellation Amount shall be reduced (but not
     below zero) to the extent necessary so that the sum of the termination fee
     described in Section 7.2(a) of the Merger Agreement (the "Termination Fee")
     paid to Grantee, the Option Share Profit (as defined below) not remitted to
     Issuer pursuant to Section 2(c) hereof, the Section 5 Repurchase
     Consideration (as defined below) paid to Grantee and the Cancellation
     Amount shall not exceed $150,000,000.  If all or a portion of the price per
     share of Issuer Common Stock offered, paid, or payable or the aggregate
     consideration offered, paid, or payable for the assets of Issuer, each as
     contemplated by the preceding sentence, consists of noncash consideration,
     such price or aggregate consideration shall be the cash


                                         -2-
<PAGE>

     consideration, if any, plus the fair market value of the noncash
     consideration as mutually determined by the investment bankers of Issuer
     and the investment bankers of Grantee.  In no event shall (i) the
     Cancellation Amount exceed $150,000,000 or (ii) the sum of the Termination
     Fee paid, the Option Share Profit not remitted to Issuer pursuant to
     Section 2(c) hereof, the Section 5 Repurchase Consideration paid and the
     Cancellation Amount paid exceed $150,000,000.

          (c)  In the event that Grantee at any time sells, pledges, or
     otherwise disposes of (including, without limitation, by merger or
     exchange) any of the Option Shares (a "Sale"), or in the event that any
     Cancellation Amount or Section 5 Repurchase Consideration is paid to
     Grantee or any Option Share Profit is received by Grantee (and not required
     to be remitted to Issuer pursuant to this Section 2(c)), then any
     Termination Fee due and payable by Issuer shall be reduced to the extent
     necessary so that the sum of

               (v)  the Termination Fee;

               (w)  any Cancellation Amount paid to Grantee;

               (x)  any Section 5 Repurchase Consideration paid to Grantee;

               (y)  the amount received (whether in cash, loan proceeds,
          securities, or otherwise) by Grantee in such Sale less the exercise
          price of such Option Shares sold in the Sale (the "Option Share
          Profit") and not remitted to Issuer pursuant to this Section 2(c); and

               (z)  Option Share Profit received in connection with any prior
          sales of Option Shares and not remitted to Issuer pursuant to this
          Section 2(c),

     shall not exceed $150,000,000.  Grantee shall remit to Issuer, within ten
     business days after completion of any Sale, the amount, if any, by which
     the Option Share Profit from such Sale which, when added to the Termination
     Fee previously paid, the Cancellation Amount previously paid, the Section 5
     Repurchase Consideration previously paid and the Option Share Profit from
     prior sales of Option Shares not remitted to Issuer pursuant to this
     Section 2(c), exceeds $150,000,000.

     3.   PAYMENT OF OPTION PRICE AND DELIVERY OF CERTIFICATE.  Any Closings
under Section 2 hereof shall be held at the principal executive offices of
Issuer, or at such other place as Issuer and Grantee may agree.  At any Closing
hereunder, (a) Grantee or its designee will make payment to Issuer of the
aggregate price for the Option Shares being so purchased by delivery of a
certified check, official bank check, or wire transfer of funds pursuant to
Issuer's instructions payable to Issuer in an amount equal to the product
obtained by multiplying the Option Price by the number of Option Shares to be
purchased, and (b) upon receipt of such payment (and the satisfaction or waiver
of the conditions set forth in Section 10 hereof) Issuer will deliver to Grantee
or its designee (which shall be a wholly-owned subsidiary of Grantee) a
certificate or certificates representing the number of validly issued, fully
paid, and nonassessable Option


                                         -3-
<PAGE>

Shares so purchased, in the denominations and registered in such names (which
shall be Grantee or a wholly-owned subsidiary of Grantee) designated in writing
to Issuer by Grantee.

     4.   REGISTRATION AND LISTING OF OPTION SHARES.

          (a)  Issuer agrees to use commercially reasonable efforts to (i)
     effect as promptly as possible upon the request of Grantee and (ii) cause
     to become and remain effective for a period of not less than six months (or
     such shorter period as may be necessary to effect the distribution of any
     Option Shares specified in such request) the registration under the 1933
     Act, and any applicable state securities laws, of the resale of all or any
     part of the Option Shares as may be specified in such request; provided,
     however, that (A) Grantee shall have the right to select the managing
     underwriter for any such offering after consultation with Issuer, which
     managing underwriter shall be reasonably acceptable to Issuer, (B) Grantee
     shall not be entitled to more than two effective registration statements
     hereunder, and (C) Grantee shall not be entitled to request such a
     registration statement within a period of one year after the effective date
     of a registration statement in which Grantee included or was entitled to
     include all or a portion of the Option Shares.  The obligations of Issuer
     hereunder to file a registration statement and to maintain its
     effectiveness may be suspended for one or more periods of time not
     exceeding 90 days in the aggregate in any one year period if the Board of
     Directors of Issuer shall have determined in good faith that the filing of
     such registration or the maintenance of its effectiveness would require
     disclosure of nonpublic information that would materially and adversely
     affect Issuer.  Upon receipt of notice of the happening of any event as a
     result of which any registration statement, prospectus, prospectus
     supplement, or any document incorporated by reference in any of the
     foregoing, contains any untrue statements of material fact or fails or
     omits to state any material fact required to be stated therein or necessary
     to make the statements therein, in light of the circumstances under which
     they are made, not misleading, Grantee shall forthwith discontinue the
     disposition of any shares under such reistration statement, prospectus or
     prospectus supplement until Grantee receives from Issuer copies (which
     subject to the limitations on suspension set forth above shall promptly be
     made available by Issuer) of an amended or supplemented registration
     statement, prospectus or supplement so that, as thereafter delivered to
     purchases of such shares, such registration statement, prospectus or
     prospectus supplement shall not contain any untrue statement of material
     fact or fail or omit to state any material fact required to be stated
     therein or necessary to make the statements therein, in light of the
     circumstances under which they are made, not misleading.

          (b)  In addition to such demand registrations, if Issuer proposes to
     effect a registration of Issuer Common Stock for its own account or for the
     account of any other stockholder of Issuer (other than in connection with
     (i) employee stock option plans or other employee or consultant benefit
     arrangements or (ii) corporate or business acquisitions), Issuer will give
     prompt written notice to Grantee of its intention to do so and shall use
     commercially reasonable efforts to include therein all Option Shares


                                         -4-
<PAGE>

     requested by Grantee to be so included; provided, however, that, if the
     managing underwriter of the offering covered by such registration advises
     Issuer that in its opinion the number of Option Shares requested to be
     included in such registration exceeds the number that can be sold in such
     offering, Issuer shall, after fully including therein all securities to be
     sold by Issuer, include the shares requested to be included therein by
     Grantee pro rata (based on the number of shares intended to be included
     therein) with the shares intended to be included therein by persons other
     than Issuer.  In connection with any offering, sale and delivery of Option
     Shares pursuant to a registration statement effected pursuant to this
     Section 4(b), Grantee shall provide Issuer and each underwriter of the
     offering with customary representations, warranties and covenants.  No
     registration effected under this Section 4(b) shall relieve Issuer of its
     obligations to effect demand registrations under Section 4(a) hereof.

          (c)  Registrations effected under this Section 4 shall be effected at
     Issuer's expense, including the fees and expenses of counsel to Grantee,
     but excluding underwriting discounts and commissions to brokers or dealers.
     In connection with each registration under this Section 4, Issuer shall
     indemnify and hold Grantee, its underwriters, and each of their respective
     affiliates harmless against any and all losses, claims, damage,
     liabilities, and expenses (including, without limitation, investigation
     expenses and fees and disbursements of counsel and accountants), joint or
     several, to which Grantee, its underwriters, and each of their respective
     affiliates may become subject, under the 1933 Act or otherwise, insofar as
     such losses, claims, damages, liabilities, or expenses (or actions in
     respect thereof) arise out of or are based upon an untrue statement or
     alleged untrue statement of a material fact contained in any registration
     statement (including any prospectus therein), or any amendment or
     supplement thereto, or arise out of or are based upon the omission or
     alleged omission to state therein a material fact required to be stated
     therein or necessary to make the statements therein not misleading, other
     than such losses, claims, damages, liabilities, or expenses (or actions in
     respect thereof) that arise out of or are based upon an untrue statement or
     alleged untrue statement of a material fact contained in written
     information furnished by Grantee to Issuer expressly for use in such
     registration statement.

          (d)  In connection with any registration statement pursuant to this
     Section 4, Grantee agrees to furnish Issuer with such information
     concerning itself and the proposed sale or distribution as shall reasonably
     be required in order to ensure compliance with the requirements of the 1933
     Act.  In addition, Grantee shall indemnify and hold Issuer, its
     underwriters and each of their respective affiliates harmless against any
     and all losses, claims, damages, liabilities, and expenses (including,
     without limitation, investigation expenses and fees and disbursements of
     counsel and accountants), joint or several, to which Issuer, its
     underwriters, and each of their respective affiliates may become subject
     under the 1933 Act or otherwise, insofar as such losses, claims, damages,
     liabilities, or expenses (or actions in respect thereof) arise out of or
     are based upon an untrue statement or alleged untrue statement of a
     material fact contained in written information furnished by Grantee to
     Issuer expressly for use in such registration statement.


                                         -5-
<PAGE>


     (e)  Upon the issuance of Option Shares hereunder, Issuer will use
commercially reasonable efforts promptly to cause such Option Shares to be
quoted on Nasdaq or on such national or other exchange on which the shares of
Issuer Common Stock are at the time listed or quoted.

     5.   REPURCHASE AT THE OPTION OF ISSUER.

          (a)  At the request of Issuer at any time during the 180-day period
     commencing on the 180th day after the date on which the Option was first
     exercised in whole or in part (the "Call Period"), Issuer may repurchase
     from Grantee, and Grantee shall sell to Issuer, up to 95% of the shares of
     Issuer Common Stock acquired by Grantee pursuant hereto and with respect to
     which Grantee has beneficial ownership at the time of such repurchase at a
     price per share equal to the Repurchase Price (defined below) per share in
     respect of the shares so acquired (such price per share multiplied by the
     number of shares of Issuer Common Stock to be repurchased pursuant to this
     Section 5 being herein called the "Section 5 Repurchase Consideration").
     The date on which Issuer exercises its rights under this Section 5 by
     delivering its request to Grantee is referred to as the "Issuer Request
     Date."  Issuer's rights under this Section 5 shall be suspended (and the
     Call Period shall be extended accordingly) during any period when the
     exercise of such rights would subject Grantee to liability pursuant to
     Section 16(b) of the Exchange Act by reason of the issuance of the Option,
     any adjustment pursuant to Section 11 hereof, or the Grantee's purchase of
     any Option Shares hereunder.  "Repurchase Price" per share shall be the sum
     of (i) the Option Price plus (ii) the amount that results from dividing (A)
     $150,000,000 minus the sum of (I) any Termination Fee paid to Grantee, (II)
     any Option Share Profit not remitted to Issuer pursuant to Section 2(c)
     hereof, (III) any Section 5 Repurchase Consideration paid to Grantee
     pursuant to this Section 5 plus (IV) any Cancellation Amount paid to
     Grantee by (B) the initial number of Option Shares covered by the Option,
     provided, however, that notwithstanding anything to the contrary contained
     in this Agreement, if the Option becomes exercisable as a result of the
     Exercise Event referred to in Section 2(a)(ii) hereof, the Repurchase Price
     shall be equal to the Option Price if the repurchase of shares pursuant to
     this Section 5 is completed before the occurrence of the event specified in
     clause (D) of Section 7.2(a)(ii) of the Merger Agreement.

          (b)  The Section 5 Repurchase Consideration to be paid in connection
     with any repurchase request shall be reduced to the extent necessary so
     that the sum of

               (v)  the Section 5 Repurchase Consideration to be paid in the
          repurchase which is the subject of Issuer's repurchase request at
          issue;

               (w)  any Section 5 Repurchase Consideration previously paid;

               (x)  any Cancellation Amount paid to Grantee;

               (y)  any Termination Fee paid to Grantee; and


                                         -6-
<PAGE>

               (z)  any Option Share Profit not remitted to Issuer pursuant to
          Section 2(c),

     shall not exceed $150,000,000.

          (c)  If Issuer exercises its rights under this Section 5, Issuer
     shall, within five business days after the Issuer Request Date, pay the
     Section 5 Repurchase Consideration, subject to reduction as provided in
     Section 5(b) above, in immediately available funds, and Grantee shall
     surrender to Issuer certificates evidencing the shares of Issuer Common
     Stock purchased hereunder, and Grantee shall warrant to Issuer that,
     immediately prior to the repurchase thereof pursuant to this Section 5,
     Grantee had sole record and beneficial ownership of such shares and that
     such shares were then held free and clear of all Encumbrances.

     6.   REPRESENTATIONS AND WARRANTIES OF ISSUER.  Issuer hereby represents
and warrants to Grantee as follows:

          (a)  Issuer is a corporation duly organized, validly existing, and in
     good standing under the laws of the State of Delaware and has all requisite
     corporate power and authority to enter into and perform this Agreement.

          (b)  The execution and delivery of this Agreement by Issuer and the
     consummation by Issuer of the transactions contemplated hereby have been
     duly and validly authorized by the Board of Directors of Issuer, and except
     to the extent of any Nasdaq requirements, no other corporate proceedings on
     the part of Issuer are necessary to authorize this Agreement or to
     consummate the transactions contemplated hereby.  The Board of Directors of
     Issuer has duly approved the issuance and sale of the Option Shares, upon
     the terms and subject to the conditions contained in this Agreement, and
     the consummation of the transactions contemplated hereby.  This Agreement
     has been duly and validly executed and delivered by Issuer and, assuming
     this Agreement has been duly and validly authorized, executed, and
     delivered by Grantee, constitutes a valid and binding obligation of Issuer
     enforceable against Issuer in accordance with its terms, subject to
     bankruptcy, insolvency, reorganization, moratorium, or other similar laws
     affecting or relating to creditors, rights generally; the availability of
     injunctive relief and other equitable remedies and general principles of
     equity; and limitations imposed by law on indemnification for liability
     under federal securities laws.

          (c)  Except as may be required in accordance with Nasdaq requirements,
     Issuer has taken all necessary action to authorize and reserve for issuance
     and to permit it to issue, and at all times from the date of this Agreement
     through the date of expiration of the Option will have reserved for
     issuance upon exercise of the Option, such number of authorized shares of
     Issuer Common Stock as is equal to the number of Option Shares (or such
     other amount as may be required pursuant to Section 11 hereof), each of
     which, upon issuance pursuant to this Agreement and when paid for as
     provided herein, will be


                                         -7-
<PAGE>

     validly issued, fully paid, and nonassessable, and shall be delivered free
     and clear of all claims, liens, charges, encumbrances, and security
     interests and not subject to any preemptive rights (collectively,
     "Encumbrances").

          (d)  Except as may be required in accordance with Nasdaq requirements,
     the execution, delivery, and performance of this Agreement by Issuer and
     the consummation by it of the transactions contemplated hereby except as
     required by the HSR Act (if applicable), and, with respect to Section 4,
     compliance with the provisions of the 1933 Act and any applicable state
     securities laws, do not require the consent, waiver, approval, license, or
     authorization of or result in the acceleration of any obligation under, or
     constitute a default under, any term, condition, or provision of any
     charter or bylaw, or any indenture, mortgage, lien, lease, agreement,
     contract, instrument, order, judgment, ordinance, regulation, or decree or
     any restriction to which Issuer or any property of Issuer or its
     subsidiaries is bound, except where the failure to obtain such consents,
     waivers, approvals, licenses, or authorizations or where such acceleration
     or defaults could not, individually or in the aggregate, reasonably be
     expected to have a Company Material Adverse Effect.

          (e)  The Company has taken all action and completed all amendments, if
     any, necessary or appropriate so that (i) the Rights Agreement dated as of
     February 26, 1997, as amended, between the Company and BankBoston, N.A.
     (the "Company Rights Agreement"), is inapplicable to the transactions
     contemplated by this Agreement, the Agreements to Facilitate Merger, and
     the Merger Agreement, and (ii) the execution of this Agreement, the
     Agreements to Facilitate Merger, and the Merger Agreement, and the
     consummation of the transactions contemplated hereby and thereby, do not
     and will not (w) result in Grantee being an "Acquiring Person" (as such
     term is defined in the Company Rights Agreement), (x) result in the ability
     of any person to exercise any Rights under the Company Rights Agreement,
     (y) enable or require the Rights to separate from the shares of Company
     Common Stock to which they are attached or to be triggered or become
     exercisable, or (z) otherwise result in the occurrence of a "Distribution
     Date" or "Shares Acquisition Date" (as such terms are defined in the
     Company Rights Agreement).

     7.   REPRESENTATIONS AND WARRANTIES OF GRANTEE.  Grantee hereby represents
and warrants to Issuer that:

          (a)  Grantee is a corporation duly organized, validly existing, and in
     good standing under the laws of the State of Minnesota and has all
     requisite corporate power and authority to enter into and perform this
     Agreement.

          (b)  The execution and delivery of this Agreement by Grantee and the
     consummation of the transactions contemplated hereby have been duly and
     validly authorized by the Board of Directors of Grantee, and no other
     corporate proceedings on the part of Grantee are necessary to authorize
     this Agreement or to consummate the transactions contemplated hereby.  This
     Agreement has been duly and validly executed


                                         -8-
<PAGE>

     and delivered by Grantee and, assuming this Agreement has been duly
     executed and delivered by Issuer, constitutes a valid and binding
     obligation of Grantee enforceable against Grantee in accordance with its
     terms, subject to bankruptcy, insolvency, reorganization, moratorium, or
     other similar laws affecting or relating to creditors' rights generally;
     the availability of injunctive relief and other equitable remedies; and
     limitations imposed by law on indemnification for liability under federal
     securities laws.

          (c)  Grantee or its designee is acquiring the Option and it will
     acquire the Option Shares issuable upon the exercise thereof for its own
     account and not with a view to the distribution or resale thereof in any
     manner not in accordance with applicable law.

     8.   COVENANTS OF GRANTEE.  Grantee agrees not to transfer or otherwise
dispose of the Option or the Option Shares, or any interest therein, except in
compliance with the 1933 Act and any applicable state securities law.  Grantee
further agrees to the placement of the following legend on the certificates
representing the Option Shares (in addition to any legend required under
applicable state securities laws):

          "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
          UNDER EITHER (1) THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"),
          OR (2) ANY APPLICABLE STATE LAW GOVERNING THE OFFER AND SALE OF
          SECURITIES.  NO TRANSFER OR OTHER DISPOSITION OF THESE SHARES, OR OF
          ANY INTEREST THEREIN, MAY BE MADE EXCEPT PURSUANT TO AN EFFECTIVE
          REGISTRATION STATEMENT UNDER THE ACT AND SUCH OTHER STATE LAWS OR
          PURSUANT TO EXEMPTIONS FROM REGISTRATION UNDER THE ACT, SUCH OTHER
          STATE LAWS, AND THE RULES AND REGULATIONS PROMULGATED THEREUNDER."

     9.   COMMERCIALLY REASONABLE EFFORTS.  Grantee and Issuer shall take, or
cause to be taken, all reasonable action to consummate and make effective the
transactions contemplated by this Agreement, including, without limitation,
commercially reasonable efforts to obtain any necessary consents of third
parties and governmental agencies (including, without limitation, compliance
with any Nasdaq approvals or requirements) and the filing by Grantee and Issuer
promptly after the date hereof of any required HSR Act notification forms and
the documents required to comply with the HSR Act.

     10.  CERTAIN CONDITIONS.  The obligation of Issuer to issue Option Shares
at a Closing under this Agreement after exercise of the Option shall be subject
to the satisfaction or waiver of the following conditions:

          (a)  any waiting periods applicable to the acquisition of the Option
     Shares by Grantee pursuant to this Agreement under the HSR Act shall have
     expired or been terminated;


                                         -9-
<PAGE>

          (b)  the representations and warranties of Grantee made in Section 6
     of this Agreement shall be true and correct in all material respects as of
     the date of the Closing for the issuance of such Option Shares;

          (c)  no order, decree, or injunction entered by any court of competent
     jurisdiction or governmental, regulatory, or administrative agency or
     commission in the United States shall be in effect that prohibits the
     exercise of the option or acquisition of Option Shares pursuant to this
     Agreement; and

          (d) compliance with any Nasdaq approvals or requirements.

     11.  ADJUSTMENTS UPON CHANGES IN CAPITALIZATION.  In the event of any
change in the number of issued and outstanding shares of Issuer Common Stock by
reason of any stock dividend, stock split, recapitalization, merger, rights
offering, share exchange, or other change in the corporate or capital structure
of Issuer, Grantee shall receive, upon exercise of the Option, the stock or
other securities, cash, or property to which Grantee would have been entitled if
Grantee had exercised the Option and had been a holder of record of shares of
Issuer Common Stock on the record date fixed for determination of holders of
shares of Issuer Common Stock entitled to receive such stock or other
securities, cash, or property at the same aggregate price as the aggregate
Option Price of the Option Shares.

     12.  EXPIRATION.  The Option shall expire at the earlier of (a) the
Effective Time (as defined in the Merger Agreement), (b) one year after the
termination of the Merger Agreement in accordance with the terms thereof in the
event Section 7.2(a)(i) of the Merger Agreement applies, or one year after the
event specified in Section 7.2(a)(ii)(D) of the Merger Agreement occurs in the
event such Section 7.2(a)(ii) applies, or (c) termination of the Merger
Agreement in accordance with the terms thereof in circumstances under which the
fee specified in Section 7.2 thereof cannot in any circumstances become payable
(such expiration date is referred to as the "Expiration Date").

     13.  GENERAL PROVISIONS.

          (a)  SURVIVAL.  All of the representations, warranties, and covenants
     contained herein shall survive each Closing and shall be deemed to have
     been made as of the date hereof and as of the date of each Closing.

          (b)  FURTHER ASSURANCES.  If Grantee exercises the Option, or any
     portion thereof, in accordance with the terms of this Agreement, Issuer and
     Grantee will execute and deliver all such further documents and instruments
     and use commercially reasonable efforts to take all such further action as
     may be necessary in order to consummate the transactions contemplated
     thereby.

          (c)  SEVERABILITY.  It is the desire and intent of the parties that
     the provisions of this Agreement be enforced to the fullest extent
     permissible under the law and public policies applied in each jurisdiction
     in which enforcement is sought.  Accordingly, in the


                                         -10-
<PAGE>

     event that any provision of this Agreement would be held in any
     jurisdiction to be invalid, prohibited, or unenforceable for any reason,
     such provision, as to such jurisdiction, shall be ineffective, without
     invalidating the remaining provisions of this Agreement or affecting the
     validity or enforceability of such provision in any other jurisdiction.
     Notwithstanding the foregoing, if such provision could be more narrowly
     drawn so as not be invalid, prohibited, or unenforceable in such
     jurisdiction, it shall, as to such jurisdiction, be so narrowly drawn,
     without invalidating the remaining provisions of this Agreement or
     affecting the validity or enforceability of such provision in any other
     jurisdiction.

          (d)  ASSIGNMENT.  This Agreement shall be binding on and inure to the
     benefit of the parties hereto and their respective successors and assigns;
     provided, however, that Issuer shall not be entitled to assign or otherwise
     transfer any of its rights or obligations hereunder, and Grantee shall not
     be entitled to assign or otherwise transfer the Option or any of its rights
     or obligations hereunder.

          (e)  SPECIFIC PERFORMANCE.  The parties agree and acknowledge that in
     the event of a breach of any provision of this Agreement, the aggrieved
     party would be without an adequate remedy at law.  The parties therefore
     agree that in the event of a breach of any provision of this Agreement, the
     aggrieved party may elect to institute and prosecute proceedings in any
     court of competent jurisdiction to enforce specific performance or to
     enjoin the continuing breach of such provision, as well as to obtain
     damages for breach of this Agreement.  By seeking or obtaining any such
     relief, the aggrieved party will not be precluded from seeking or obtaining
     any other relief to which it may be entitled.

          (f)  AMENDMENTS.  This Agreement may not be modified, amended,
     altered, or supplemented except upon the execution and delivery of a
     written agreement executed by Grantee and Issuer.

          (g)  NOTICES.  All notices, requests, claims, demands, and other
     communications hereunder shall be in writing and shall be deemed to be
     sufficient if contained in a written instrument and shall be deemed given
     if delivered personally, telecopied, sent by nationally-recognized
     overnight courier or mailed by registered or certified mail (return receipt
     requested), postage prepaid, to the other party at the following addresses
     (or such other address for a party as shall be specified by like notice):

          If to Grantee:

               Medtronic, Inc.
               7000 Central Avenue N.E.
               Minneapolis, NN 55432
               with separate copies thereof addressed to

               Attention:     General Counsel


                                         -11-
<PAGE>

                         FAX:  (612) 572-5459
               and

               Attention:     Vice President and Chief Development Officer
                              FAX: (612) 572-5404

          If to Issuer:

               Arterial Vascular Engineering, Inc.
               3576 Unocal Place
               Santa Rosa, CA 95403
               FAX:  (707) 541-3190
               Attention:  General Counsel

               with a copy to:

               Cooley Godward LLP
               Five Palo Alto Square
               3000 El Camino Real
               Palo Alto, CA 94306-2155
               FAX: (650) 857-0663
               Attention:  Craig E. Dauchy, Esq. and
                           Richard E. Climan, Esq.

          (h)  HEADINGS.  The headings contained in this Agreement are for
     reference purposes only and shall not affect in any way the meaning or
     interpretation of this Agreement.

          (i)  COUNTERPARTS.  This Agreement may be executed in one or more
     counterparts, each of which shall be an original, but all of which together
     shall constitute one and the same agreement.

          (j)  GOVERNING LAW.  This Agreement shall be governed by and construed
     in accordance with the laws of the State of Delaware applicable to
     contracts made and to be performed therein.

          (k)  ENTIRE AGREEMENT.  This Agreement, the Confidentiality Agreement,
     and the Merger Agreement and any documents and instruments referred to
     herein and therein constitute the entire agreement between the parties
     hereto and thereto with respect to the subject matter hereof and thereof
     and supersede all other prior agreements and understandings, both written
     and oral, between the parties with respect to the subject matter hereof and
     thereof.  This Agreement shall be binding upon, inure to the benefit of,
     and be enforceable by the successors and permitted assigns of the parties
     hereto.  Nothing in this Agreement shall be construed to give any person
     other than the parties to this



                                         -12-
<PAGE>

     Agreement or their respective successors or permitted assigns any legal or
     equitable right, remedy, or claim under or in respect of this Agreement or
     any provision contained herein.

          (l)  EXPENSES.  Except as otherwise provided in this Agreement or the
     Merger Agreement, each party shall pay its own expenses incurred in
     connection with this Agreement.


                                         -13-
<PAGE>


     IN WITNESS WHEREOF, the parties have caused this Stock Option Agreement to
be signed by their respective officers thereunto duly authorized as of the date
first written above.

                              MEDTRONIC, INC.


                              By:/s/ Michael D. Ellwein
                                 ---------------------------
                              Its: Vice President CDO
                                  --------------------------

                              ARTERIAL VASCULAR ENGINEERING, INC.


                              By:/s/ Lawrence J. Fassler
                                 ---------------------------
                              Its: Vice President, General
                                  --------------------------
                                   Counsel and Secretary
                                  --------------------------


                                         -14-


<PAGE>


                                                                       Exhibit 5
                              FREDRIKSON & BYRON, P.A.
                                  ATTORNEYS AT LAW
                             1100 International Centre
                              900 Second Avenue South
                            Minneapolis, MN  55402-3397
                                   (612) 347-7000
                                FAX: (612) 347-7077

                                 December 18, 1998
Medtronic, Inc.
7000 Central Avenue N.E.
Minneapolis, Minnesota  55432

Re:  REGISTRATION STATEMENT ON FORM S-4

Ladies/Gentlemen:

     We are acting as counsel for Medtronic, Inc. (the "Company"), a Minnesota
corporation, in connection with the registration by the Company of 58,146,865
shares of the Company's Common Stock, par value $.10 (the "Shares"), each of
which shares includes the Preferred Stock Purchase Rights attached thereto (the
"Rights"), pursuant to the Company's Registration Statement on Form S-4 being
filed with the Securities and Exchange Commission (the "Registration
Statement").  The Shares and the Rights are to be issued in connection with the
merger of MAV Merger Corp. ("Merger Subsidiary"), a wholly-owned subsidiary of
the Company, with and into Arterial Vascular Engineering, Inc. ("AVE"), pursuant
to the Agreement and Plan of Merger dated as of November 29, 1998 by and among
the Company, Merger Subsidiary, and AVE (the "Merger Agreement").

     In connection with rendering this opinion, we have examined and relied upon
originals or copies, certified or otherwise identified to our satisfaction, of
such corporate records, agreements and other instruments, certificates of
officers, certificates of public officials and other documents as we have deemed
necessary or appropriate as a basis for the opinions expressed herein.

     In connection with our examination, we have assumed the genuineness of all
signatures, the authenticity of all documents tendered to us as originals, the
legal capacity of all natural persons and the conformity to original documents
of all documents submitted to us as certified or photostatic copies.

     Based on, and subject to, the foregoing, it is our opinion that:

     1.  The Company has the corporate authority to issue the Shares and the
Rights in the manner and under the terms set forth in the Registration
Statement.

     2.  The Shares have been duly authorized and, when issued and delivered to
holders of AVE common stock in accordance with the Merger Agreement, will be
validly issued, fully paid and nonassessable.

     3.  The Rights have been duly authorized and, when issued and delivered in
accordance with the Shareholder Rights Plan referred to in the Registration
Statement, will be validly issued, fully paid and nonassessable.


<PAGE>

     We hereby consent to the filing of this opinion as Exhibit 5 to the
Registration Statement, to its use as a part of the Registration Statement and
to the use of our name under the caption "Legal Matters" in the Proxy
Statement/Prospectus constituting a part of the Registration Statement.

                                        Very truly yours,

                                        /s/ Fredrikson & Byron, P.A.

                                        FREDRIKSON & BYRON, P.A.


<PAGE>

                                                                     Exhibit 8.1

                       [LETTERHEAD OF COOLEY GODWARD LLP]

December 18, 1998

Arterial Vascular Engineering, Inc.
3576 Unocal Place
Santa Rosa, CA  95403

RE:    AGREEMENT AND PLAN OF MERGER BY AND AMONG MEDTRONIC, INC., MAV MERGER
       CORP., AND ARTERIAL VASCULAR ENGINEERING, INC. DATED AS OF NOVEMBER 29,
       1998

Ladies and Gentlemen:

You have requested our opinion as to certain United States federal income tax
consequences of the merger (the "Merger") of MAV Merger Corp. ("Merger
Subsidiary"), a Delaware corporation and a wholly-owned subsidiary of Medtronic,
Inc. ("Parent"), a Minnesota corporation, with and into Arterial Vascular
Engineering, Inc. (the "Company"), a Delaware corporation. The Merger is being
consummated pursuant to the Agreement and Plan of Merger by and among Parent,
Merger Subsidiary, and the Company dated as of November 29, 1998 (the "Merger
Agreement"). Unless otherwise defined, capitalized terms used herein have the
meanings assigned to them in the Merger Agreement.

In connection with rendering our opinion, we have reviewed the Merger Agreement,
including the Exhibits thereto, the Proxy Statement/Prospectus constituting part
of the Registration Statement on Form S-4 filed by Parent with the Securities
and Exchange Commission on December 18, 1998, and such other documents and
corporate records as we have deemed necessary or appropriate as a basis
therefor. We have assumed that the representations and warranties contained in
the Merger Agreement were true, correct and complete when made and will continue
to be true, correct and complete through the Effective Time, and that the
parties have complied with and, if applicable, will continue to comply with the
covenants contained in the Merger Agreement. We also have assumed that
statements as to factual matters contained in the Proxy Statement/Prospectus are
true, correct, and complete and will continue to be true, correct, and complete
through the Effective Time. Finally, we have relied on the representations made
by Parent and the Company in tax certificates provided to us dated December 18,
1998, and we have assumed that such representations will continue to be true,
correct, and complete through the Effective Time.

Based upon the foregoing, in reliance thereon and subject thereto, and based
upon the Internal Revenue Code of 1986, as amended (the "Code"), the Treasury
Regulations promulgated thereunder, judicial decisions, revenue rulings and
revenue procedures of the Internal Revenue 

<PAGE>

COOLEY GODWARD LLP
- ------------------

Arterial Vascular Engineering, Inc.
December 18, 1998
Page Two


Service, and other administrative pronouncements, all as in effect on the date
hereof, and assuming that the Merger and related transactions will be
consummated in accordance with the terms of the Merger Agreement, it is our
opinion that the Merger will qualify as a reorganization within the meaning of
Section 368(a) of the Code, and that each of Parent, Merger Subsidiary, and the
Company will be a party to such reorganization within the meaning of Section
368(b) of the Code. Furthermore, we hereby confirm that the discussion set forth
under the caption "The Merger--Certain Federal Income Tax Consequences" in the
Proxy Statement/Prospectus, insofar as such discussion constitutes statements of
United States federal income tax law or legal conclusions, subject to the
assumptions, limitations, and qualifications set forth therein, accurately
reflects our opinion of the material United States federal income tax
consequences of the Merger.

No opinion is expressed as to any matter not specifically addressed above,
including the accuracy of the representations or reasonableness of the
assumptions relied upon by us in rendering the opinion set forth above. Our
opinion is based on current United States federal income tax law and
administrative practice and we do not undertake to advise you as to any future
changes in United States federal income tax law or administrative practice that
may affect our opinion unless we are specifically retained to do so. We consent
to the use of this opinion as an Exhibit to the Proxy Statement/Prospectus, and
to the references to Cooley Godward LLP under the captions "The Merger--Certain
Federal Income Tax Consequences" and "Legal Matters" in the Proxy
Statement/Prospectus.

Very truly yours,

/s/ Webb B. Morrow III

Webb B. Morrow III

WBM:DP

<PAGE>
                                                                 Exhibit 8.2

     FREDRIKSON & BYRON, P.A.                     1100 International Centre
     ATTORNEYS AT LAW                             900 Second Avenue South
                                                  Minneapolis, MN 55402-3397
                                                  (612) 347-7000
                                                  FAX (612) 347-7077


                                 December 18, 1998


Medtronic, Inc.
7000 Central Avenue N.E.
Minneapolis, Minnesota  55432

     RE:  Agreement and Plan of Merger by and among Medtronic, Inc., MAV Merger
          Corp., and Arterial Vascular Engineering, Inc. dated as of November
          29, 1998

Ladies and Gentlemen:

     You have requested our opinion as to certain United States federal income
tax consequences of the merger (the "Merger") of MAV Merger Corp. ("Merger
Subsidiary"), a Delaware corporation and a wholly-owned subsidiary of Medtronic,
Inc. ("Parent"), a Minnesota corporation, with and into Arterial Vascular
Engineering, Inc. (the "Company"), a Delaware corporation.  The Merger is being
consummated pursuant to the Agreement and Plan of Merger by and among Parent,
Merger Subsidiary, and the Company dated as of November 29, 1998 (the "Merger
Agreement").  Unless otherwise defined, capitalized terms used herein have the
meanings assigned to them in the Merger Agreement.

     In connection with rendering our opinion, we have reviewed the Merger
Agreement, including the Exhibits thereto, the Proxy Statement/Prospectus
constituting part of the Registration Statement on Form S-4 filed by Parent with
the Securities and Exchange Commission on December 18, 1998, and such other
documents and corporate records as we have deemed necessary or appropriate as a
basis therefor.  We have assumed that the representations and warranties
contained in the Merger Agreement were true, correct and complete when made and
will continue to be true, correct and complete through the Effective Time, and
that the parties have complied with and, if applicable, will continue to comply
with the covenants contained in the Merger Agreement.  We also have assumed that
statements as to factual matters contained in the Proxy Statement/Prospectus are
true, correct, and complete and will continue to be true, correct, and complete
through the Effective Time.  Finally, we have relied on the representations made
by Parent and the Company in tax certificates provided to us dated December 18,
1998, and we have assumed that such representations will continue to be true,
correct, and complete through the Effective Time.


<PAGE>

     Based upon the foregoing, in reliance thereon and subject thereto, and
based upon the Internal Revenue Code of 1986, as amended (the "Code"), the
Treasury Regulations promulgated thereunder, judicial decisions, revenue rulings
and revenue procedures of the Internal Revenue Service, and other administrative
pronouncements, all as in effect on the date hereof, and assuming that the
Merger and related transactions will be consummated in accordance with the terms
of the Merger Agreement, it is our opinion that the Merger will qualify as a
reorganization within the meaning of Section 368(a) of the Code, and that each
of Parent, Merger Subsidiary, and the Company will be a party to such
reorganization within the meaning of Section 368(b) of the Code.  Furthermore,
we hereby confirm that the discussion set forth under the caption "The
Merger--Certain Federal Income Tax Consequences" in the Proxy
Statement/Prospectus, insofar as such discussion constitutes statements of
United States federal income tax law or legal conclusions, subject to the
assumptions, limitations, and qualifications set forth therein, accurately
reflects our opinion of the material United States federal income tax
consequences of the Merger.

     No opinion is expressed as to any matter not specifically addressed 
above, including the accuracy of the representations or reasonableness of the 
assumptions relied upon by us in rendering the opinion set forth above.  Our 
opinion is based on current United States federal income tax law and 
administrative practice and we do not undertake to advise you as to any 
future changes in United States federal income tax law or administrative 
practice that may affect our opinion unless we are specifically retained to 
do so.  We consent to the use of this opinion as an Exhibit to the Proxy 
Statement/Prospectus, and to the references to Fredrikson & Byron, P.A. under 
the captions "The Merger--Certain Federal Income Tax Consequences" and "Legal 
Matters" in the Proxy Statement/Prospectus.


                                             Very truly yours,

                                             /s/ Fredrikson & Byron, P.A.

                                             FREDRIKSON & BYRON, P.A.


<PAGE>

                                                                    Exhibit 23.3

                         CONSENT OF INDEPENDENT ACCOUNTANTS


We hereby consent to the incorporation by reference in the Proxy
Statement/Prospectus constituting part of this Registration Statement on Form
S-4 of Medtronic, Inc. of our report dated May 26, 1998, except as to Note 16
which is as of November 2, 1998 and Note 2 which is as of September 30, 1998,
appearing in the Current Report on Form 8-K of Medtronic, Inc. filed November
30, 1998.  We also consent to the incorporation by reference of our report on
the Supplemental Financial Statement Schedule, which appears in Exhibit 23.1 of
such Current Report on Form 8-K.  We also consent to the reference to us under
the heading "Experts" in the Proxy Statement/Prospectus.


/s/ PricewaterhouseCoopers LLP

PRICEWATERHOUSECOOPERS LLP

Minneapolis, Minnesota
December 17, 1998



<PAGE>


                                                                    Exhibit 23.4

                CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the reference to our firm under the caption "Experts" in the
Registration Statement (Form S-4) and related Prospectus of Medtronic, Inc. 
for the registration of shares by Medtronic, Inc. of its common stock and to 
the incorporation by reference therein of our report dated July 17, 1998, 
with respect to the consolidated financial statements of Arterial Vascular 
Engineering, Inc., included in its Annual Report (Form 10-K) for the year 
ended June 30, 1998, filed with the Securities and Exchange Commission.


                                                  /s/ Ernst & Young LLP

                                                  ERNST & YOUNG LLP

Palo Alto, California
December 17, 1998



<PAGE>

                                 [LETTERHEAD]


                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS



As independent public accountants, we hereby consent to the incorporation by 
reference in this Form S-4 of our report on the Statements of Net Assets to 
be Sold and Net Revenues and Certain Expenses of C.R. Bard, Inc. Cardiology 
Division - Coronary Catheter Lab Products as of December 31, 1997 and 1996 
and for the years ended December 31, 1997, 1996 and 1995 dated September 30, 
1998 included in Arterial Vascular Engineering, Inc.'s Registration Statement 
File No. 333-53421.  It should be noted that we have not audited any 
financial statements of C.R. Bard, Inc. Cardiology Division - Coronary 
Catheter Lab Products subsequent to December 31, 1997 or performed any audit 
procedures subsequent to the date of our report.


                                                 /s/ Arthur Andersen LLP

                                                 ARTHUR ANDERSEN LLP


Roseland, New Jersey
December 17, 1998

<PAGE>

                                                                    Exhibit 23.6

                     CONSENT OF SG COWEN SECURITIES CORPORATION


We hereby consent to the inclusion of our opinion, dated November 29, 1998, in
the proxy statement/prospectus of Arterial Vascular Engineering, Inc. and
Medtronic, Inc., which is a part of this Registration Statement on Form S-4 and
to the references to such opinion in such proxy statement/prospectus.  In 
executing this consent, we do not admit or acknowledge that SG Cowen Securities
Corporation is within the class of persons whose consent is required by Section
7 of the Securities Act of 1933, as amended, or the rules and regulations
promulgated thereunder.


Date:  December 18, 1998

                                             SG COWEN SECURITIES CORPORATION


                                             By: /s/ Robert Valdez
                                                --------------------------------
                                                Name:  Robert Valdez
                                                Title: Managing Director


<PAGE>

                                                                      Exhibit 24

                                  POWER OF ATTORNEY


     KNOW ALL BY THESE PRESENTS, that each of the undersigned directors and
officers of Medtronic, Inc., a Minnesota corporation ("Medtronic"), hereby
constitutes and appoints WILLIAM W. GEORGE and RONALD E. LUND, or either of
them, their true and lawful attorneys-in-fact and agents, each with full power
and authority to act as such without the other, with full power of substitution
and resubstitution, for the undersigned and in the undersigned's name, place and
stead, in any and all capacities, to do any and all acts and things and to
execute any and all instruments that any of said attorneys and agents may deem
necessary or advisable in connection with Medtronic's acquisition of Arterial
Vascular Engineering, Inc., to enable Medtronic to comply with the Securities
Act of 1933, as amended, with any regulations, rules or requirements of the
Securities and Exchange Commission thereunder, and with any state Blue Sky laws
or regulations in connection therewith, including specifically, but without
limiting the generality of the foregoing, power and authority to sign the names
of the undersigned to the Registration Statement on Form S-4, to any amendment
to such Registration Statement, and to any other registration statement,
prospectus, instrument or document filed with said Commission as a part of or in
connection with such Registration Statement or any amendment thereto, including
but not limited to registration statements on Form S-8; and the undersigned
hereby ratify and confirm all that said attorneys and agents, or their
substitutes or resubstitutes, may lawfully do or cause to be done by virtue
hereof.

    IN WITNESS WHEREOF, the undersigned have subscribed these presents 
effective as of the 24th day of November, 1998.


   /s/ William R. Brody, M.D., Ph.D.    /s/ Glen D. Nelson, M.D.
   -------------------------------      -------------------------------
   William R. Brody, M.D., Ph.D.        Glen D. Nelson, M.D.

   /s/ Paul W. Chellgren                /s/ Robert L. Ryan
   -------------------------------      -------------------------------
   Paul W. Chellgren                    Robert L. Ryan

   /s/ Arthur D. Collins, Jr.           /s/ Jean-Pierre Rosso
   -------------------------------      -------------------------------
   Arthur D. Collins, Jr.               Jean-Pierre Rosso

   /s/ William W. George                /s/ Richard L. Schall
   -------------------------------      -------------------------------
   William W. George                    Richard L. Schall

   /s/ Antonio M. Gotto, Jr., M.D.      /s/ Jack W. Schuler
   -------------------------------      -------------------------------
   Antonio M. Gotto, Jr., M.D.          Jack W. Schuler

   /s/ Bernadine P. Healy, M.D.         /s/ Gerald W. Simonson
   ------------------------------       -------------------------------
   Bernadine P. Healy, M.D.             Gerald W. Simonson

   /s/ Thomas E. Holloran               /s/ Gordon M. Sprenger
   ------------------------------       -------------------------------
   Thomas E. Holloran                   Gordon M. Sprenger

                                        /s/ Richard A. Swalin, Ph.D.
                                        -------------------------------
                                        Richard A. Swalin, Ph.D.


<PAGE>

                                                                    Exhibit 99.1

                        ARTERIAL VASCULAR ENGINEERING, INC.
                          SPECIAL MEETING OF SHAREHOLDERS

            THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.

     The undersigned shareholder hereby appoints Scott J. Solano, John D. 
Miller and Lawrence J. Fassler and each of them as proxies, each with full 
power of substitution, to vote as designated below all shares of common stock 
of Arterial Vascular Engineering, Inc. held of record as of December 21, 
1998, which the undersigned would be entitled to vote if personally present 
at the Special Meeting of Shareholders to be held on [January 28], 1999, at 
10:00 a.m., local time, at Luther Burbank Center for the Arts, East 
Auditorium, 50 Mark West Springs Road, Santa Rosa, California, and at any 
adjournment or adjournments thereof, upon the following matters:

     Proposal to approve the Agreement and Plan of Merger providing for the
merger of MAV Merger Corp. into Arterial Vascular Engineering, Inc., with
Arterial Vascular Engineering, Inc. to be the surviving corporation and a
wholly-owned subsidiary of Medtronic, Inc., copies of which Agreement and Plan
of Merger is attached as Annex A to the Proxy Statement/Prospectus for the
Special Meeting.

     / /FOR                       / / AGAINST                 / / ABSTAIN

               (CONTINUED AND TO BE SIGNED AND DATED ON THE OTHER SIDE)

     This proxy will be voted as specified by the shareholder, but if no choice
is specified, this proxy will be voted FOR approval of the Agreement and Plan of
Merger.  If this proxy is not returned, the effect will be a vote against the
Merger.  The persons acting as proxies will have discretion to vote on any other
matters properly presented for consideration at the Special Meeting or any
adjournment or adjournments thereof in accordance with their best judgment.

     IMPORTANT:  Please sign exactly as name or names appear on this Proxy.
Joint owners should each sign personally.  When signing as attorney, executor,
administrator, trustee or guardian, please give your full title as such.  When
signing as a corporation or a partnership, please sign in the name of the entity
by an authorized person.

Dated:
       ----------------------

                                 -----------------------------------------------
                                 (Please sign name exactly as it appears hereon)

                                 -----------------------------------------------
                                 (Signature of joint owner, if any)

                                PLEASE MARK, DATE, SIGN AND RETURN THIS PROXY
                                IN THE ENCLOSED PROXY RETURN ENVELOPE, WHICH
                                REQUIRES NO POSTAGE IF MAILED IN THE UNITED
                                STATES.  IF AN ENVELOPE IS NOT ENCLOSED OR HAS
                                BEEN MISPLACED, PLEASE RETURN THIS COMPLETED
                                PROXY TO BOSTON EQUISERVE, 150 ROYALL STREET,
                                CANTON, MASSACHUSETTS 02021. 




© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission