MILLIPORE CORP
SC 13D, 1996-04-18
LABORATORY ANALYTICAL INSTRUMENTS
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             SECURITIES AND EXCHANGE COMMISSION
                    Washington, DC  20549
                              
                        SCHEDULE 13D
                              
          Under the Securities Exchange Act of 1934

                      PerSeptive Biosystems, Inc.
                      (Name of Issuer)
                              
                      Common stock, $0.01 Par Value
               (Title of Class of Securities)
                              
                         715271 10 2
                       (CUSIP Number)
                              
                       Geoffrey Nunes
                    MILLIPORE CORPORATION
                        80 Ashby Road
                      Bedford, MA 01730
                       (617) 533-2209
                              
 (Name, Address and Telephone Number of Person Authorized to
             Receive Notices and Communications)
                              
                      August 22, 1995
   (Date of Event Which Requires Filing of this Statement)

   If  the  filing person has previously filed a statement  on
Schedule 13G to report the acquisition which is the subject of
this Schedule 13D, and is filing this schedule because of Rule
13d-1(b)(3) or (4), check the following box [   ].

   Check  the following box if a fee is being paid  with  this
statement   [  X  ].   (A  fee is not  required  only  if  the
reporting  person:   (1)  has  a previous  statement  on  file
reporting  beneficial ownership of more than five  percent  of
the class of securities described in Item 1; and (2) has filed
no amendment subsequent thereto reporting beneficial ownership
of less than five percent of such class.  See Rule 13d-7.)

  * The remainder of this cover page shall be filled out for a
reporting person's initial filing of this form with respect to
the  subject  class  of  securities, and  for  any  subsequent
amendment containing information which would alter disclosures
provided in a prior cover page.

  The information required on the remainder of this cover page
shall  not be deemed to be "filed" for the purposes of Section
18 of the Securities Exchange Act of 1934 ("Act") or otherwise
subject  to  the liabilities of that section of  the  Act  but
shall  be subject to all other provisions of the Act (however,
see the Notes).
CUSIP No.  715271 10 2

1)  Name of Reporting Persons/S.S. or I.R.S. Identification Nos.
of Above Persons
  1.  Millipore Corporation                  /04-2170233
  2.  Millipore Investment Holdings Ltd.     /51-0321703

2)  Check the Appropriate Row if a member of a Group (See
Instructions)
     (a)                 X
     (b)

3)  SEC Use Only

4)  Source of Funds (See Instructions)                     OO

5)  Check if Disclosure of Legal Proceedings is Required
Pursuant to Item 2(d)
or 2(e)

6)  Citizenship or Place of Organization
Millipore Corporation -- Massachusetts
  Millipore Investment Holdings Ltd. --Delaware

 Number of    (7)  Sole Voting Power Millipore Corporation -- 421,436
 Shares Bene-      Millipore Investment Holdings Ltd.      -- 490,763
 ficially     (8)  Shared Voting Power    0
 Owned by     (9)  Sole Dispositive Power Millipore Corporation --  421,436
 Each Reporting           Millipore Investment Holdings Ltd. --     490,763
 Person With   (10)  Shared Dispositive Power               0

11)  Aggregate Amount Beneficially Owned by Each Reporting
Person
               Millipore Corporation --  421,436
               Millipore Investment Holdings Ltd. -- 490,763

12)  Check if the Aggregate Amount in Row (11) Excludes
Certain Shares
(See Instructions)

13)  Percent of Class Represented by Amount in Row (11)  In
aggregate 5.3%

14)  Type of Reporting Person (See Instructions)

     Millipore Corporation                     CO
     Millipore Investment Holdings Ltd.        CO



Item 1.   Security and Issuer
     Equity Securities:       Common Stock, $0.01 Par Value
     Issuer:                  PerSeptive Biosystems, Inc.
                              500 Old Connecticut Path
                              Framingham, MA  01701

Item 2.   Identity and Background
(a)                  Name:             Millipore Corporation
Millipore Investment Holdings Ltd.
(b)                  State of Organization:  Massachusetts  Delaware
(c)                  Address of Principal    80 Ashby Road  1013
Centre Road, Suite 350
     Business & Office:                Bedford, MA 01730
Wilmington, DE  19805
(d)                  Criminal Proceedings:   Not Applicable Not
Applicable
(e)                  Civil Injunction
   relating to Federal or
   State Securities laws:              Not Applicable  Not
Applicable

Item 3.   Source and Amount of Funds or Other Consideration
Millipore Corporation:    The reported shares
                    of Common Stock of PerSeptive Biosystems, Inc. were received
                    upon the redemption of 462.5 shares of the Series A
                    Redeemable Convertible Preferred  Stock, $0.01 Par Value, of
                    PerSeptive Biosystems, Inc. which was part of an aggregate
                    of 1,850 shares of such Preferred Stock delivered to
                    Millipore Corporation in partial consideration for the
                    divestiture sale of the physical assets and goodwill of
                    Millipore Corporation's Life Science Division.
Millipore Investment  The reported shares of Common Stock of PerSeptive
Holdings Ltd.:      Biosystems,  Inc. were  received  upon
                    the  redemption of 537.5 shares of the
                    Series    A   Redeemable   Convertible
                    Preferred  Stock, $0.01 Par Value,  of
                    PerSeptive Biosystems, Inc. which  was
                    part  of an aggregate of 2,150  shares
                    of  such Preferred Stock delivered  to
                    Millipore   Corporation   in   partial
                    consideration for the divestiture sale
                    of  the  intellectual property related
                    to the former Life Science Division of
                    Millipore Corporation.

Item 4.   Purpose of Transaction
      The  shares  of  Common Stock of PerSeptive Biosystems,
   Inc.  reported  herein  were  acquired  by  the  reporting
   persons   as  a  result  of  the  election  by  PerSeptive
   Biosystems,  Inc. to redeem the first installment  of  its
   Series  A  Redeemable Convertible Preferred  Stock,  $0.01
   Par   Value,  on  the  required  redemption  date  by  the
   conversion  of  an  aggregate  of  1,000  shares  of  such
   Preferred Stock into Common Stock in accordance  with  the
   terms  of the Certificate of Designations with respect  to
   such  Preferred  Stock.  An aggregate of 4,000  shares  of
   Series  A  Redeemable  Convertible  Preferred  Stock  were
   delivered   to   Millipore   Corporation   and   Millipore
   Investment Holdings Ltd. pursuant to the divestiture  sale
   of   the   former  Millipore  Life  Science  Division   to
   PerSeptive  Biosystems,  Inc. on  August  22,  1994.   The
   shares  of such Preferred Stock are mandatorily redeemable
   in  four  equal  annual installments on August  22,  1995,
   1996,  1997 and 1998 at a cash redemption price of $10,000
   per  share or by conversion into that number of shares  of
   Common  Stock of PerSeptive Biosystems yielded by dividing
   $10,000  per share by the average closing price  for  such
   Common  Stock on the 10 trading days ending on  the  fifth
   business day prior to each redemption date.  Reference  is
   made  to  the  Certificate  of Designations  of  Series  A
   Redeemable  Convertible Preferred Stock, $0.01 Par  Value,
   of PerSeptive Biosystems, Inc. attached as Exhibit 1.
(a)    It  is expected that future mandatory redemptions  of
       such  Preferred  Stock  may be effected  through  the
       conversion   into  additional  shares  of  PerSeptive
       Biosystems, Inc. Common Stock.
(b)-(j)While  the reporting persons are entitled to  certain
       rights  in  the  event  of a  default  by  PerSeptive
       Biosystems,  Inc.  in its obligation  to  redeem  the
       shares   of   the  Series  A  Redeemable  Convertible
       Preferred  Stock  on the mandatory redemption  dates;
       neither  of the reporting persons have any  plans  or
       proposals  relating  to  material  changes   in   the
       issuer's  business or corporate structure,  including
       those  matters enumerated in paragraphs  (b)  through
       (j) of Item 4 to Schedule 13D.

Item 5.   Interest in Securities of the Issuer.
(a)  Millipore Corporation                     421,436 shares  2.4%*
     Millipore Investment Holdings Ltd.        490,763 shares 2.8%*
                                               912,199        5.3%*

  *  Based  on 17,287,533 shares outstanding as of  March
      29,  1996,  as  reported in PerSeptive  Biosystems,
      Inc.   Proxy   Statement  for  Annual  Meeting   of
      Stockholders to be held May 6, 1996, dated April 3,
      1996.
(b)   Millipore Corporation 421,436 shares sole power to vote or
                                    dispose
      Millipore Investment Holdings Ltd.  490,763 shares sole power to
                                          vote or dispose
(c)  There  have been no transactions in the Common  Stock  of
     PerSeptive Biosystems, Inc. by the persons enumerated  in
     paragraph (a) above within the last 60 days.
(d)-(e) Paragraphs (d) & (e) of Item 5 of Schedule 13D are Not
     Applicable.
Item 6.Contracts, Arrangements, Understandings or
       Relationships With Respect to Securities of the
       Issuer.
This Item is Not Applicable.

Item 7.   Material to be Filed as Exhibits.
(1)   Certificate   of  Designations,  Series   A   Redeemable
      Convertible  Preferred  Stock,  ($0.01  Par  Value)   of
      PerSeptive Biosystems, Inc.

                          SIGNATURE

  After reasonable inquiry and to the best of my knowledge and
belief,  I  certify  that the information set  forth  in  this
statement is true, complete and correct.

                                        April 17, 1996
                                           (Date)

                                MILLIPORE CORPORATION


                                By:/s/ Geoffrey Nunes
                                 Geoffrey  Nunes, Senior Vice President

                          MILLIPORE INVESTMENT HOLDINGS LTD.



                                     By: /s/ Peter Walcott
                                     Peter  W.  Walcott,  Vice President
Witness: /s/ Paul O'Connor
Nashua, New Hampshire



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