MGI PHARMA INC
S-8, 1998-06-25
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
      As filed with the Securities and Exchange Commission on June 25, 1998
                                                      Registration No. 333-_____
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  -----------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                  -----------

                                MGI PHARMA, INC.
             (Exact name of registrant as specified in its charter)

            Minnesota                                            41-1364647
  (State or other jurisdiction                                (I.R.S. Employer
of incorporation or organization)                            Identification No.)

      9900 Bren Road East, Suite 300E
          Minneapolis, Minnesota                                        55343
 (Address of Principal Executive Offices)                             (Zip Code)

       MGI PHARMA, INC. AMENDED AND RESTATED EMPLOYEE STOCK PURCHASE PLAN
                            (full title of the plan)


            Lori-jean Gille                                Copy to:
               Secretary                             Timothy S. Hearn, Esq.
           MGI PHARMA, INC.                          Dorsey & Whitney LLP
    9900 Bren Road East, Suite 300E                 220 South Sixth Street
     Minneapolis, Minnesota 55343             Minneapolis, Minnesota  55402-1498
(Name and address of agent for service)

                                 (612) 935-7335
          (Telephone number, including area code, of agent for service)

                                  -----------

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
===================================================================================================================
                                                     Proposed                   Proposed
  Title of each class                            Maximum Offering               Maximum
  of Securities to be    Amount to be                 Price                Aggregate Offering        Amount of 
     registered           registered (1)             per Unit (2)                Price (2)       Registration Fee(2)
- -------------------------------------------------------------------------------------------------------------------
<S>                      <C>                    <C>                        <C>                   <C>
    Common Stock
   ($.01 par value)         150,000                    $6.922                   $1,038,281.25          $306.29
===================================================================================================================
</TABLE>
(1)  The number of shares being registered represents the number of shares of
     Common Stock that may be issued pursuant to the MGI PHARMA, INC. Amended
     and Restated Employee Stock Purchase Plan (the "Plan") in addition to
     250,000 shares previously registered under the Plan.

(2)  Pursuant to Rule 457(h)(1), the proposed maximum offering price per share
     and the proposed maximum aggregate offering price are based upon the
     average of the high and low prices of the Common Stock reported in the
     Nasdaq National Market on June 22, 1998.

Pursuant to General Instruction E to Form S-8, this Registration Statement
incorporates by reference the Registration Statements on Form S-8 relating to
the Plan filed with the Securities and Exchange Commission on June 3, 1988 (File
No. 33-22294) and June 25, 1993 (File No. 33-65032).

================================================================================
<PAGE>
 
                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Minneapolis, State of Minnesota, on June 25, 1998.

                                         MGI PHARMA, INC.

                                         By /s/ Charles N. Blitzer
                                            ----------------------------------
                                            Charles N. Blitzer
                                            President, Chief Executive Officer


     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
         Name                                        Title                                       Date
         ----                                        -----                                       ----
<S>                                            <C>                                            <C>
     /s/ Charles N. Blitzer                    President, Chief Executive                     June 25, 1998
- ----------------------------------             Officer (principal executive
     Charles N. Blitzer                        officer) and Director

               *                               Vice President, Finance (principal
- ----------------------------------             financial and accounting officer)
        William C. Brown                       

               *                               Director
- ----------------------------------             
       Andrew J. Ferrara

               *                               Director
- ----------------------------------             
  Joseph S. Frelinghuysen, Jr.

               *                               Director
- ----------------------------------             
       Michael E. Hanson

               *                               Director
- ----------------------------------             
        Hugh E. Miller

               *                               Director
- ----------------------------------             
       Timothy G. Rothwell

               *                               Director
- ----------------------------------             
        Lee J. Schroeder


*By  /s/ Charles N. Blitzer                                                                   June 25, 1998
- ----------------------------------             
        Charles N. Blitzer
         Attorney-in-Fact
</TABLE>
<PAGE>
 
                                 EXHIBIT INDEX

Exhibit Number     Description
- --------------     -----------
      5            Opinion of Dorsey & Whitney LLP regarding legality

     23.1          Consent of KPMG Peat Marwick LLP

     23.2          Consent of Dorsey & Whitney LLP (included in Exhibit 5 to
                   this Registration Statement)

     24            Power of Attorney

<PAGE>
 
                                                                       EXHIBIT 5


                      [LETTERHEAD OF DORSEY & WHITNEY LLP]


                                  June 18, 1998


MGI PHARMA, INC.
9900 Bren Road East, Suite 300E
Minneapolis, Minnesota 55343


Ladies and Gentlemen:

         We have acted as counsel to MGI PHARMA, INC., a Minnesota corporation
(the "Company"), in connection with the preparation of a Registration Statement
on Form S-8 relating to the sale by the Company from time to time of up to
150,000 shares of Common Stock, $.01 par value per share, of the Company (the
"Shares"), issuable pursuant to the Company's Amended and Restated Employee
Stock Purchase Plan (the "Plan").

         We have examined such documents and have reviewed such questions of law
as we have considered necessary and appropriate for the purposes of the opinions
set forth below.

         In rendering our opinions set forth below, we have assumed the
authenticity of all documents submitted to us as originals, the genuineness of
all signatures and the conformity to authentic originals of all documents
submitted to us as copies. We have also assumed the legal capacity for all
purposes relevant hereto of all natural persons and, with respect to all parties
to agreements or instruments relevant hereto other than the Company, that such
parties had the requisite power and authority (corporate or otherwise) to
execute, deliver and perform such agreements or instruments, that such
agreements or instruments have been duly authorized by all requisite action
(corporate or otherwise), executed and delivered by such parties and that such
agreements or instruments are the valid, binding and enforceable obligations of
such parties. As to questions of fact material to our opinions, we have relied
upon certificates of officers of the Company and of public officials.

         Based on the foregoing, we are of the opinion that the Shares have been
duly authorized and, upon issuance, delivery and payment therefor in accordance
with the terms of the Plan, will be validly issued, fully paid and
nonassessable.

         Our opinions expressed above are limited to the laws of the State of
Minnesota.

         We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement.


                                       Very truly yours,


                                       /s/ Dorsey & Whitney LLP


TSH

<PAGE>
 
                                                                    EXHIBIT 23.1



                         INDEPENDENT AUDITORS' CONSENT

The Board of Directors and Shareholders
MGI PHARMA, INC.:

     We consent to the use of our reports incorporated herein by reference in
this Registration Statement on Form S-8 of MGI PHARMA, INC.

                                       /s/ KPMG Peat Marwick LLP




Minneapolis, Minnesota
June 25, 1998

<PAGE>
 
                                                                      EXHIBIT 24

                                POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below hereby constitutes and appoints Charles N. Blitzer and Lori-jean
Gille, and each of them, his true and lawful attorneys-in-fact and agents, each
acting alone, with full power of substitution and resubstitution, for him and in
his name, place and stead, in any and all capacities, to sign a Registration
Statement on Form S-8 of MGI PHARMA, INC. (the "Company") relating to the
Company's Amended and Restated Employee Stock Purchase Plan, and any and all
amendments thereto, including post-effective amendments, and to file the same,
with all exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and
agents, each acting alone, full power and authority to do and perform each and
every act and thing requisite or necessary to be done in and about the premises,
as fully to all intents and purposes as he or she might or could do in person,
hereby ratifying and confirming all that said attorneys-in-fact and agents, each
acting alone, or his or her substitute or substitutes, may lawfully do or cause
to be done by virtue hereof.

<TABLE>
<CAPTION>
         Name                                        Title                                       Date
         ----                                        -----                                       ----
<S>                                            <C>                                            <C>
 /s/ Charles N. Blitzer                        President, Chief Executive                     June 17, 1998
- ----------------------------------             Officer (principal executive
     Charles N. Blitzer                        officer) and Director
                                               

 /s/ William C. Brown                          Vice President, Finance (principal             June 24, 1998
- ----------------------------------             financial and accounting officer)
     William C. Brown                          


 /s/ Andrew J. Ferrara                         Director                                       June 19, 1998
- ----------------------------------             
     Andrew J. Ferrara


 /s/ Joseph S. Frelinghuysen, Jr.              Director                                       June 18, 1998
- ----------------------------------             
     Joseph S. Frelinghuysen, Jr.


 /s/ Michael E. Hanson                         Director                                       June 16, 1998
- ----------------------------------             
     Michael E. Hanson


 /s/ Hugh E. Miller                            Director                                       June 17, 1998
- ----------------------------------             
     Hugh E. Miller


 /s/ Timothy G. Rothwell                       Director                                       June 22, 1998
- ----------------------------------             
     Timothy G. Rothwell


 /s/ Lee J. Schroeder                          Director                                       June 25, 1998
- ----------------------------------             
     Lee J. Schroeder
</TABLE>


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