CAMBRIDGE BIOTECH CORP
10-K/A, 1995-05-01
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                   PART III


Item 10.       DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.

       Pursuant to General Instruction G(3) of Form 10-K, the following
information with respect to directors is included in Part III of this Report.

       The following is a list of directors of Cambridge Biotech Corporation,
their ages, positions, offices and business experience, as of March 1, 1995:

       John S. Scott, 68, has served as a Director since May 1989 and as
Chairman of the Board since December 1989.  Mr. Scott is the retired Chairman
(1987) of Richardson-Vicks, Inc., a diversified consumer products subsidiary of
The Procter & Gamble Company.  He served as President and Chief Executive
Officer of Richardson-Vicks, Inc. from 1975 until being named Chairman in 1986.
He was a director of Richardson-Vicks, Inc. from 1975 until his retirement in 
1987 and of Procter & Gamble from 1986 until his retirement.  Mr. Scott holds 
a B.A. degree from Brown University.  He is a director of Fleet Financial 
Group, Inc., The Perkin-Elmer Corporation, The Stanley Works, and Creative 
Products  Resource, Inc.  Mr. Scott serves as a member on the Company's 
compensation committee and as a member on the Company's nominating committee.

       Jeffrey T. Beaver, 57, has served as President and Chief Executive
Officer of the Company since May 1994.  Mr. Beaver has also served as a
director since January 1983.  From January 1991 to May 1994, Mr. Beaver was an
independent consultant in the health care sector.  From September 1986 to
December 1990, Mr. Beaver was Senior Vice President and Head of the Corporation
Finance Group of IBJ Schroder Bank and Trust Company.  Prior to September 1986,
Mr. Beaver was a Managing Director of J. Henry Schroder Corporation (a
subsidiary of Schroder Venture Managers, Inc.) where he was engaged in
providing corporate financial advisory services.  Mr. Beaver is a member of the
Institute of Chartered Financial Analysts.  He received his B.A. degree from
Princeton University and his M.B.A. degree from New York University.

       C. Arnold Kalman, 75, has served as a director since March 1989.  Mr.
Kalman has worked for the consulting firm of Booz Allen & Hamilton since 1950,
becoming a partner in the firm in 1956 and has retired as Senior Vice President
of the firm.  Mr. Kalman's clients were primarily in industry with
technology-based products.  Mr. Kalman received his B.S. from the Massachusetts
Institute of Technology.  Mr. Kalman is a former director of several public
companies including AXIA Incorporated, and Electronic Memories & Magnetics
Corp.  Mr. Kalman is chairman of the Company's nominating committee and a
member of the audit committee.

       John H. Kellogg, 71, has served as a director since January 1983.  Mr.
Kellogg retired from the practice of law and resigned from Kellogg & George,
P.C., on September 1, 1994, where he had been a partner since 1977.  Mr.
Kellogg specializes in small business development, finance and acquisitions. 
He has been a founder in the following technology-based manufacturing
companies:  Thermal Circuits, Inc., Kittiwake Corp., Tadco, Inc. and Astron,
Inc., all based in New England.  Additionally, he is a partner in small
partnerships which own and operate industrial real estate; these include:  Tor
Co., Gimlet Realty, and Jefferson Realty.  Mr. Kellogg received his B.S. degree
in Mechanical Engineering at the Massachusetts Institute of Technology and a
J.D. degree from Harvard Law School.  Mr. Kellogg is chairman of the Company's
compensation committee.

       John M. Nelson, 63, has served as a director since January 1987.  Mr.
Nelson was elected, in May of 1991, Chairman and Chief Executive Officer of
Wyman-Gordon Company, a manufacturer of technically advanced forgings,
investment castings and composites principally for aircraft structures and jet
engines.  From January 1988 until September 1990, Mr. Nelson was Chairman and
Chief Executive Officer of Norton Company, a manufacturer of abrasives,
ceramics, plastics, and chemical process products.  From 1979 to September
1990, he was a director of Norton.  Prior to becoming Chief Executive Officer
of Norton, Mr. Nelson was President and Chief Operating Officer of Norton from
1986 to 1988, and, for more than five years, was President and Chief Executive
Officer of its subsidiary, Norton Christensen, Inc.  Mr. Nelson holds a B.A.
degree from Wesleyan University and a M.B.A. from Harvard Business School.  He
is a director of Brown & Sharpe Manufacturing Company, Stocker & Yale, Inc.,
Commerce Holdings, Inc., and The TJX Companies, Inc.  Mr. Nelson serves on the
Company's compensation and nominating committees.


       W. Samuel Nisbet, 59, has served as a director since September 1990. 
From 1965 to December 31, 1994, when he retired, Mr. Nisbet's principal
occupation or employment was with SIGNET Bank/Maryland where he was a Vice
President.  Mr. Nisbet serves on the Company's audit committee.

       Thomas T. Taylor, 52, has served as a director since September 1990. 
Mr. Taylor has been President and a director of Chesapeake Securities Research
Corporation (formerly known as Offutt & Taylor, Inc.), an investment banking
firm located in Towson, Maryland, since 1983.  From 1983 to November 1984, Mr.
Taylor was Co-Director of the Chesapeake Research Division of Baker, Watts &
Co. and from 1979 to 1983, Mr. Taylor served as Co-Director of the Mid-Atlantic
Research Division of Legg Mason Wood Walker, Inc.  Mr. Taylor holds a B.A.
degree from the University of Virginia and a M.B.A. degree from Loyola College,
Baltimore, Maryland.  Mr. Taylor became a Chartered Financial Analyst in 1976. 
Mr. Taylor serves on the Company's compensation and audit committees.

       Douglas Yee, 39, has served as a Director since September 1990.  He has
been an Associate Professor of Medicine, Division of Medical Oncology, at the
University of Texas Health Science Center at San Antonio since September 1993. 
He was an Assistant Professor from July 1989 to August 1993.  From August 1988
to June 1989, he was an Instructor in the Department of Medicine at the
Georgetown University Medical Center.  Dr. Yee received a B.S. degree from the
University of Michigan and an M.D. degree from the University of Chicago.  Dr.
Yee serves on the Company's Nominating Committee.

       There are no family relationships between any of the above individuals
or between any of the above individuals and any director of the Company.

Compliance with Section 16(a) of the Securities Exchange Act of 1934.

       Section 16(a) of the Securities Exchange Act of 1934 (the "Act")
requires the Company's directors and executive officers and persons who own
more than ten percent of a registered class of the Company's equity securities
to file with the Securities and Exchange Commission ("SEC") initial reports of
ownership and reports of changes in ownership of common stock of the Company. 
These persons are required by SEC regulation to furnish the Company with copies
of all Section 16(a) forms they file.  To the Company's knowledge, based solely
on a review of the copies of such reports furnished to the Company and written
representations that no other reports are required during the fiscal year ended
December 31, 1994, one report covering a transaction was filed late by Mr.
Leonard and one report covering a transaction was filed late by James C. Bass. 

Item 11.       EXECUTIVE COMPENSATION.

       The following table sets forth certain information as to the annual and
long-term compensation for services to the Company for the Company's last three
completed fiscal years of the Company's Chief Executive Officers and one other
most highly compensated executive officer of the Company as of December 31,
1994 (collectively the "Named Executive Officers").


                                                   Long-Term     
                             Annual Compensation   Compensation  
                                                          AWARDS
                                           Other    Restric-          All
                                           Annual   ted               Other
Name and Principal                         Compen-  Stock    Options  Compen-
Position           Year   Salary   Bonus   sation   Award(s) /SARs(1) sation(2)

                         
Patrick J. Leonard  1994  $140,574  $0       ---      0          0    $1,748
President/CEO and   1993   302,961   0       ---      0          0     4,497
Director (3)        1992   274,845   0       ---      0          0     3,888    
 
Jeffrey T. Beaver   1994    97,231   0         0      0      80,000     ---
President/CEO,      1993             0       ---      0       5,000
Treasurer           1992             0       ---      0       5,000
and Director (4) 
                
Gary E. Long        1994   125,000   0       ---      0      15,000     1,875
Vice President -    1993   125,029 19,500    ---      0          0      1,872
Operations          1992   118,817   0       ---      0          0      1,916

  (1) Although the Company's 1989 Stock Award and Option Plan permits 
      grants of stock appreciation rights, no awards of SARs have been made.

  (2) The amounts shown for each of the Named Executive Officers represent
      contributions by the Company to the Company's Savings Plan for the 
      benefit of the respective Named Executive Officer.

  (3) Dr. Leonard was terminated on May 9, 1994.

  (4) Mr. Beaver was appointed President and Chief Executive Officer on 
      May 9, 1994.



              OPTION/SAR GRANTS - LONG TERM INCENTIVE PLAN AWARDS

                                                       
                     Individual Grants
         

Name     Number of  Percent    Exercise  Expira-   Potential       Alternative
(a)      Securities of Total   of Base   tion Date Realizable Value (f) and (g)
         underlying Options/   Price     (e)       at Assumed      Grant Date
         option/SARs SARs      ($/Sh.)             Annual Rates    Value   
         Granted    Granted to (d)                 of Stock Price 
         (#)        Employees                      Appreciation  
         (b)        in Fiscal                      for Option Term
                    Year                          
                    (c)                            5% ($)  10% ($)  Grant Date
                                                  (f)      (g)      Present
                                                                    Value $
                                                                    (h)   
                                                              
Patrick J. ---        ---        ---      ---       ---    ----- 
Leonard     
             
Jeffrey    5,000      ---       2.44    1/4/2004    7,650  19,443  --
T. Beaver 75,000      ---     1.1687    6/2/2005   55,124 139,695  -- 
  
Gary E.   15,000      ---     3.3125    2/1/2004   31,248  79,189  -- 
 Long   
        

                    Fiscal Year End Option/SAR Value Table

    The following chart shows the number and value of unexercised options 
    held by each of the Named Executive Officers at the end of the Company's 
    last fiscal year.  The value shown for each option is equal to the 
    difference between the exercise price of the option and the fair market 
    value of the underlying stock at fiscal year end.  The Company has never 
    awarded any stock appreciation rights to any of its employees, and thus 
    none are outstanding.  None of the Named Executive Officers exercised 
    any options during the Company's last fiscal year.

                                                                              
                            Number of             Value of
                            Unexercised          Unexercised
                          Options/SARs at       In-the-Money 
Name                      Fiscal Year-End      Options/SARs at 
                                               Fiscal Year-End
                                                                              
                           Exercisable/        Exercisable/  
                           Unexercisable       Unexercisable                 

Patrick J. Leonard               0                  $0.00
Jeffrey T. Beaver          126,750/8,250            $0.00
Gary E. Long               80,626/105,000           $0.00

                                                                              


    The Directors' fees, which includes retainer fees that are paid quarterly
and fees for attendance at the regular meetings of the Board of Directors, for
fiscal year end December 31, 1994 were as follows:  John S. Scott - $93,500.00
(deferred payment of $66,000.00, paid $27,500.00); Jeffrey T. Beaver -
23,625.86 (deferred payment <PAGE>
of $23,625.86); C. Arnold Kalman - $24,643.14 
(deferred payment of $24,634.14); John H. Kellogg - $19,500.00 (deferred 
payment of $19,500.00); John M. Nelson - $20,000.00 (deferred payment of 
$20,000.00); W. Samuel Nisbet - $19,000.00 (deferred payment of $19,000.00); 
Thomas T. Taylor - $24,634.14 (deferred payment of $24,634.14); and Douglas 
Yee - $15,000.00 (deferred payment of $15,000.00).  The directors have agreed 
to defer payment of the director fees until the earlier to occur of the date 
on which the Company emerges from bankruptcy or January 1996.

   The Company entered into employment contracts with several of its officers
as described below.  

    Ms. Arntsen entered into an employment agreement with the Company on July
20, 1993 which was to terminate on July 20, 1995.  Ms. Arntsen resigned as of
January 1, 1995.

    Dr. Leonard entered into an employment agreement with the Company on July 1,
1993 which was terminated on May 9, 1994. 

    Mr. Long entered into an employment agreement with the Company on April 23,
1991, with a salary of $114,500.00, subject to review on an annual basis.  

Board Compensation Committee Report on Executive Compensation

    Traditionally, the Company's compensation for its executive officers,
including its chief executive officer, has consisted of three key elements: 
base  salary, discretionary annual bonus, and periodic grants of stock 
options or other long-term compensation. The Company's compensation 
committee (the "Committee") has historically made judgements as to the 
components of compensation based upon its review of the Company's results 
and each individual's performance. The Committee's goal has been to provide 
an appropriate balance between base salary and incentive compensation awarded 
upon achievement of long-term goals.

    As has been pointed out elsewhere in this Annual Report, 1994 was a
difficult and unusual year for the Company.  In May of 1994, the Company's 
chief executive officer was terminated, and its chief financial officer and 
its general counsel resigned. On July 7, 1994 the Company filed for protection 
under Chapter 11 of the United States Bankruptcy Code.  Thus the Committee was 
not working in a normal operating environment and in many respects was unable 
to play its traditional role of establishing consistent long-term performance-
based compensation goals.  
    
    Dr. Leonard's base salary of $303,000 was determined under the terms of 
an employment contract effective May 18, 1993. The Committee had limited 
discretion with respect to base salaries of other executive officers, all of 
whom are under employment contracts;  but with respect to those executive 
officers for whom the Committee had the option to increase base pay the 
Committee elected not to grant any increases.  The Committee also determined 
not to pay any cash bonuses under the Company's 1993 bonus plan except a 
bonus to one former executive officer which was required by contract and two 
bonuses of $5,000 each payable in restricted stock to former executive 
officers.  The shares of restricted stock have been returned to the Company 
pursuant to the terms of the restriction.  

    In March of 1994, the Compensation Committee established certain 
parameters for a management bonus plan for 1994 under which Dr. Leonard, the 
Company's former chief executive officer and the Company's other executive 
officers were eligible for discretionary bonuses.  The plan provided for 
discretionary bonus awards as a percentage of salary based upon the attainment 
of certain specified goals both individual and corporate, including the 
achievement of corporate financial performance targets. The CEO was eligible 
for a bonus of up to 50% of his base salary with the other executive officers 
being eligible for bonuses up to 35% of their respective base salaries.  No 
awards were granted under this bonus plan, and the bonus plan was not 
implemented due to the occurrence of subsequent events which have been 
previously described. 

     The Committee felt it appropriate to award long-term incentives to 
executive officers and the CEO with the goal of tying the executives 
compensation to an increase in long-term shareholder value.  The Committee 
granted two of its executive officers options to purchase 35,000 shares in 
the aggregate vesting over a three year period. The committee granted Dr. 
Leonard an option to purchase 100,000 shares early in 1994 which option 
was exercisable only upon the achievement of certain performance standards 
which were not met.  The option has expired due to Dr. Leonard's leaving the 
employ of the Company.  


    With the departure of Dr. Leonard, Mr. Beaver was elected as CEO of the
Company.  The  Committee, taking into account the uncertainty of the Company's
position, set Mr. Beaver's base salary at $160,000 and granted him an option 
to purchase 75,000 shares of the Company's common stock at a price equal to 
110% of the fair market value on the day of the grant.  It is not expected 
that any of the stock options granted prior to the Company's bankruptcy will 
have any material value in a reorganized Company.   

    As part of a cost-cutting plan initiated after filing of the bankruptcy
petition, members of senior management, including the Company's executive
officers and Mr. Beaver, took salary reductions of from 5% to 20% of their 
base salary.  In order to provide incentive to employees including senior 
management, the Committee recommended submission to the bankruptcy court 
for approval of an incentive plan payable in stock in the Company as 
reorganized.  The incentive plan, which has been approved by the bankruptcy 
court, gives each participant stock in the reorganized Company on the 
effective date of the Company's reorganization plan.  The amount of stock 
received is calculated using varying percentages of base salary based on 
performance.

Performance Graph

    The following graph shows a comparison over a five-year period ending at 
the end of the Company's last fiscal year of the cumulative total return to 
the Company's shareholders with the cumulative total return of the Standard 
& Poor's 500 Composite Index and the NASDAQ Pharmaceutical Index and assumes 
an investment of $100 on December 31, 1989.  

                                                         NASDAQ
                                        S&P 500       PHARMACEUTICAL
JANUARY 31,      CAMBRIDGE BIOTECH  COMPOSITE INDEX      INDEX
  1989               100.00              100.00          100.00
  1990                40.00               96.90          119.95
  1991               156.00              126.42          318.78    
  1992               114.00              136.05          265.53
  1993                40.00              149.76          236.63  
  1994                 4.00              151.74          178.40 
  

Item 12.    SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

      The following table sets forth certain information as to the Company's
common stock owned by management of the Company as of March 1, 1995 based upon
information supplied by the Company's directors and executive officers.  All
directors and executive officers have sole voting and sole investment power in
shares reported as beneficially owned by them except as may be noted.  The
State of Wisconsin Investment Board owns more than five percent (5%) of the
outstanding shares of the Company's common stock.

                                                                              
Name and Address of           Number                 Percent 
Beneficial Owner           of Shares (1)             of Class                 


John S. Scott                  161,150                   *
1191 Smith Ridge Road
New Canaan, CT  06840

Patrick J. Leonard (2)         261,119                   *
365 Plantation Street
Worcester, MA  01605

Jeffrey T. Beaver (3)          129,583                   *
225 Warren Street
Brooklyn, NY  11201

C. Arnold Kalman                45,950                   *
9 Conant Place
Darien, CT  06820
                                      
John H. Kellogg                 65,250                   *
27 Ledge Rock Road
Concord, MA  01742

John M. Nelson                  59,750                   *
7 Massachusetts Ave.
Worcester, MA  01609

W. Samuel Nisbet                33,865                   *
3025 DuBarry Lane
Brookville, MD  20833

Thomas T. Taylor                31,750                   *
3015 D. Oak Green Circle
Ellicott City, MD  21043

Douglas Yee (4)                173,700                   *
314 Branch Oak Way
San Antonio, TX  78230

Gary E. Long                    85,418                   *
26 Wayside Road
Westborough, MA  01581

Karen M. Meenan                  1,750                   *
10 Lantern Lane
Amherst, MA  01002

Keith D. Jones                  17,625                   *
365 Plantation Street
Worcester, MA  01605

Susan R. Arntsen                70,981                   *
4 Polar Bear Road
Westford, MA  01886

Directors and Executive      1,162,891                   
 Officers as a Group                                     


State of Wisconsin           2,505,000                  9.45%
 Investment Board
____________
* Less than 1%


(1)  The shares reported as owned by the directors and executive officers are
     shares that are available for purchase by them under stock options, as
     follows:  Mr. Scott - 149,150 shares, Mr. Beaver - 126,750 shares, Mr.
     Kalman - 40,950 shares, Mr. Kellogg - 51,750 shares, Mr. Nelson - 51,750
     shares, Mr. Nisbet - 31,750 shares, Mr. Taylor - 26,750 shares, Dr. Yee -
     31,750 shares, Mr. Long - 80,626 shares, Ms. Meenan - 1,750 shares, Mr.
     Jones - 17,625 shares and Ms. Arntsen - 64,076 shares.

(2)  Includes 2,200 shares held jointly with his wife and 625 shares held by 
     his wife alone.

(3)  Includes 1,000 shares held as custodian for one daughter and 1,000 shares
     held as custodian for another daughter.  Mr. Beaver disclaims beneficial
     ownership of the shares held as custodian for his daughters.

(4)  Includes 138,475 shares held by him alone and 3,475 shares held by his 
     wife alone.

ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

     None.


                                  SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this amendment to be signed on its behalf by the
undersigned thereunto duly authorized.

                             CAMBRIDGE BIOTECH CORPORATION


April 28, 1995               By: /s/ Alison Taunton-Rigby
                                 President and Chief Executive Officer





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