CHIRON CORP
S-8, 1995-12-20
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

   As filed with the Securities and Exchange Commission on December 20, 1995
                                                 Registration No. 33-___________
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             _______________________

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                               __________________
                               CHIRON CORPORATION
               (EXACT NAME OF ISSUER AS SPECIFIED IN ITS CHARTER)

           Delaware                                              94-2754624
(State or other jurisdiction of                               (I.R.S. Employer
incorporation or organization)                               Identification No.)
                  4560 Horton St., Emeryville, California 94608
                                 (510) 655-8730
          (Address, including zip code, and telephone number, including
             area code, of registrant's principal executive offices)
                               __________________

                         CHIRON 1991 STOCK OPTION PLAN
                            (Full title of the plan)
                               __________________

                            EDWARD E. PENHOET, PH.D.
                      President and Chief Executive Officer
                               CHIRON CORPORATION
                4560 Horton Street, Emeryville, California 94608
                                 (510) 655-8730
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>

- ----------------------------------------------------------------------------------------------------------------------------------
 Title of Securities                                      Proposed Maximum            Proposed Maximum               Amount of
  to be Registered          Amount to be Registered    Offering Price Per Share    Aggregate Offering Price      Registration  Fee
  -----------------         -----------------------    ------------------------    ------------------------      -----------------
<S>                         <C>                        <C>                         <C>                           <C>
Common Stock, $0.01 par         1,235,996 (1)                 $98.25 (2)               $121,436,607 (2)                $41,875
value (1991 Stock Option
Plan)
- ----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

(1)  This Registration Statement shall also cover any additional shares of
     Common Stock which become issuable under the Chiron 1991 Stock Option Plan,
     by reason of any stock dividend, stock split, recapitalization or other
     similar transaction effected without the receipt of consideration
     which results in an increase in the number of the Registrant's outstanding
     shares of Common Stock.
(2)  Calculated solely for the purposes of this offering under Rule 457(h) of
     the Securities Act of 1933 on the basis of the average of the high and low
     selling prices per share of Common Stock of Chiron Corporation on December
     18, 1995, as reported by the NASDAQ National Market System.

This Registration Statement shall become effective immediately upon filing with
the Securities and Exchange Commission, and sales of the registered securities
will begin as soon as reasonably practicable after such effective date.
                               __________________

Also relates to Registration File Nos. 33-35182, 33-20181, 2-90595, 33-44477 and
33-65024 pursuant to Rule 429 under the Securities Act of 1933.


<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

     The contents of the Registration Statement on Form S-8 (File No. 33-44477),
filed by Chiron Corporation (the "Registrant") with the Securities and Exchange
Commission on December 12, 1991, is hereby incorporated by reference herein.

ITEM 8.  EXHIBITS.

EXHIBIT NUMBER      EXHIBIT
- --------------      --------

     4.01           Rights Agreement, dated as of August 25, 1994, between the
                    Company and Continental Stock Transfer & Trust Company,
                    which includes the Certificate of Designations for the
                    Series A Junior Participating Preferred Stock as Exhibit A,
                    the form of Right Certificate as Exhibit B and the Summary
                    of Rights to Purchase Preferred Shares as Exhibit C,
                    incorporated by reference to Exhibit 4.04 of the
                    Registrant's current report on Form 8-K dated August 25,
                    1994.

     4.02           Amendment No. 1 to Rights Agreement dated as of November 20,
                    1994, between Chiron Corporation and Continental Stock
                    Transfer & Trust Company, incorporated by reference to
                    Exhibit 4.05 of the Registrant's current report on Form 8-K,
                    dated November 20, 1994.

     5              Opinion of William G. Green.
     23.1           Consent of KPMG Peat Marwick LLP, Independent Auditors,
                    relating to the 1994 consolidated financial statements of
                    Chiron Corporation and subsidiaries.
     23.2           Consent of Ernst & Young LLP, Independent Auditors, relating
                    to the 1993 and 1992 consolidated financial statements of
                    Chiron Corporation.
     23.3           Consent of Ernst & Young LLP, Independent Auditors, relating
                    to the consolidated financial statements of Ciba Corning
                    Diagnostics Corp.
     23.4           Consent of KPMG Peat Marwick LLP, Independent Auditors,
                    relating to the financial statements of The Biocine Company.
     23.5           Consent of Reconta Ernst & Young, Independent Auditors,
                    relating to the consolidated financial statements of JV Vax
                    B.V.
     23.6           Consent of Ernst & Young LLP, Independent Auditors,
                    relating to the financial statements of Viagene, Inc.
     23.7           Consent of William G. Green is contained in Exhibit 5.
     24             Power of Attorney.  Reference is made to pages II-2 and II-3
                    of this Registration Statement.
     99.1           Chiron 1991 Stock Option Plan.



                                      II-1
<PAGE>

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized in the City of Emeryville, State of California, on the 19th day of
December, 1995.


                                   CHIRON CORPORATION

                                   By /s/ Edward E. Penhoet
                                      ---------------------------------
                                      Edward E. Penhoet
                                      President and Chief Executive Officer


                                POWER OF ATTORNEY

     KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned officers and
directors of Chiron Corporation, a Delaware corporation, do hereby constitute
and appoint Edward E. Penhoet and William J. Rutter, and each of them, the
lawful attorneys and agents or attorney and agent with full power and authority
to do any and all acts and things and to execute any and all instruments which
said attorneys and agents, and any one of them, determine may be necessary or
advisable or required to enable said corporation to comply with the Securities
Act of 1933, as amended, and any rules or regulations or requirements of the
Securities and Exchange Commission in connection with this Registration
Statement.  Without limiting the generality of the foregoing power and
authority, the powers granted include the power and authority to sign the names
of the undersigned officers and directors in the capacities indicated below this
Registration Statement, to any and all amendments, both pre-effective and post-
effective, and supplements to this Registration Statement, and to any and all
instruments or documents filed as part of or in conjunction with this
Registration Statement or amendments or supplements thereof, and each of the
undersigned hereby ratifies and confirms all that said attorneys and agents, or
any one of them shall do or cause to be done by virtue hereof.  This Power of
Attorney may be signed in several counterparts.

     IN WITNESS WHEREOF, each of the undersigned has executed this Power of
Attorney as of the date indicated.



                                      II-2
<PAGE>

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the date indicated.

<TABLE>
<CAPTION>

SIGNATURE                           TITLE                              DATE
<S>                                 <C>                                <C>
/s/ Edward E. Penhoet, Ph.D.        President, Chief Executive         December 19, 1995
- -------------------------------     Officer and Director (Principal
(Edward E. Penhoet, Ph.D.)          Executive Officer)

/s/ William J. Rutter, Ph.D.        Chairman of the Board              December 19, 1995
- -------------------------------
(William J. Rutter, Ph.D.)

/s/ Dennis L. Winger                Senior Vice President, Finance     December 19, 1995
- -------------------------------     and Administration, Chief
(Dennis L. Winger)                  Financial Officer (Principal
                                    Financial and Accounting Officer)


/s/ Gilbert F. Amelio, Ph.D.        Director                           December 19, 1995
- -------------------------------
(Gilbert F. Amelio, Ph.D.)

/s/ Lewis W. Coleman                Director
- -------------------------------
(Lewis W. Coleman)

/s/ Pierre E. Douaze                Director                           December 19, 1995
- -------------------------------
(Pierre E. Douaze)

/s/ Donald A. Glaser, Ph.D.         Director                           December 19, 1995
- -------------------------------
(Donald A. Glaser, Ph.D.)

/s/ Alex Krauer, Ph.D.              Director                           December 19, 1995
- -------------------------------
(Alex Krauer, Ph.D.)

/s/ Francois L'Eplattenier, Ph.D    Director                           December 19, 1995
- -------------------------------
(Francois L'Eplattenier, Ph.D.)

/s/ Henri Schramek, Ph.D.           Director                           December 19, 1995
- -------------------------------
(Henri Schramek, Ph.D.)

/s/ Jack W. Schuler                 Director                           December 19, 1995
- -------------------------------
(Jack W. Schuler)

/s/ Pieter J. Strijkert, Ph.D.      Director                           December 19, 1995
- -------------------------------
(Pieter J. Strijkert, Ph.D.)
</TABLE>


                                      II-3

<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549


                                    EXHIBITS
                                       TO
                                    FORM S-8
                                      UNDER
                             SECURITIES ACT OF 1933

                               CHIRON CORPORATION



<PAGE>

                                  EXHIBIT INDEX



EXHIBIT NUMBER      EXHIBIT
- --------------      -------

     4.01           Rights Agreement, dated as of August 25, 1994, between the
                    Company and Continental Stock Transfer & Trust Company,
                    which includes the Certificate of Designations for the
                    Series A Junior Participating Preferred Stock as Exhibit A,
                    the form of Right Certificate as Exhibit B and the Summary
                    of Rights to Purchase Preferred Shares as Exhibit C,
                    incorporated by reference to Exhibit 4.04 of the
                    Registrant's current report on Form 8-K dated August 25,
                    1994.

     4.02           Amendment No. 1 to Rights Agreement dated as of November 20,
                    1994, between Chiron Corporation and Continental Stock
                    Transfer & Trust Company, incorporated by reference to
                    Exhibit 4.05 of the Registrant's current report on Form 8-K,
                    dated November 20, 1994.

     5              Opinion of William G. Green.

     23.1           Consent of KPMG Peat Marwick LLP, Independent Auditors,
                    relating to the 1994 consolidated financial statements of
                    Chiron Corporation and subsidiaries.
     23.2           Consent of Ernst & Young LLP, Independent Auditors, relating
                    to the 1993 and 1992 consolidated financial statements of
                    Chiron Corporation.
     23.3           Consent of Ernst & Young LLP, Independent Auditors, relating
                    to the consolidated financial statements of Ciba Corning
                    Diagnostics Corp.
     23.4           Consent of KPMG Peat Marwick LLP, Independent Auditors,
                    relating to the financial statements of The Biocine Company.
     23.5           Consent of Reconta Ernst & Young, Independent Auditors,
                    relating to the consolidated financial statements of JV Vax
                    B.V.
     23.6           Consent of Ernst & Young LLP, Independent Auditors,
                    relating to the financial statements of Viagene, Inc.
     23.7           Consent of William G. Green is contained in Exhibit 5.
     24             Power of Attorney.  Reference is made to pages II-2 and II-3
                    of this Registration Statement.
     99.1           Chiron 1991 Stock Option Plan.




<PAGE>

[CHIRON LETTERHEAD]


                                    EXHIBIT 5

December 15, 1995

Chiron Corporation
4560 Horton Street
Emeryville, CA  94608

Re:  Chiron Corporation
     Registration Statement for Offering of
     Shares of Common Stock

Ladies and Gentlemen:

In connection with your registration of 1,235,996 shares of the Common Stock of
Chiron Corporation (the "Company") on Form S-8 under the Securities Act of 1933,
as amended, I advise you that, in my opinion, when such shares have been issued
and sold pursuant to the provisions of the Chiron 1991 Stock Option Plan, and in
accordance with the Registration Statement, such shares will be duly authorized,
validly issued, fully paid and non-assessable shares of the Company's Common
Stock.

I hereby consent to filing of this opinion as an exhibit to the Registration
statement.

Very truly yours,

/s/ William G. Green

William G. Green
Senior Vice President and
General Counsel

WGG/cdb


<PAGE>

                                                       EXHIBIT 23.1

              CONSENT OF KPMG PEAT MARWICK LLP, INDEPENDENT AUDITORS


We consent to incorporation by reference in the Registration Statement
(Form S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option
Plan of our report dated February 17, 1995, relating to the consolidated
balance sheet of Chiron Corporation and subsidiaries as of December 31, 1994 and
the related consolidated statements of operations, stockholders' equity and cash
flows for the year then ended and the related schedule.

                                              KPMG PEAT MARWICK LLP



San Francisco, California
December 15, 1995





<PAGE>

                                                       EXHIBIT 23.2

              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement
(Form S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option
Plan of our report dated February 25, 1994, with respect to the 1993 and 1992
consolidated financial statements and schedule of Chiron Corporation included in
the Annual Report (Form 10-K) of Chiron Corporation for the year ended December
31, 1994, filed with the Securities and Exchange Commission.

                                                    ERNST & YOUNG LLP


San Francisco, California
December 15, 1995





<PAGE>

                                                       EXHIBIT 23.3

              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement
(Form S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option
Plan of our report dated January 27, 1995, with respect to the consolidated
financial statements of Ciba Corning Diagnostics Corp. included in the Current
Report Form 8-K/A of Chiron Corporation dated January 4, 1995, as amended on
March 17, 1995, filed with the Securities and Exchange Commission.

                                                    ERNST & YOUNG LLP



Boston, Massachusetts
December 15, 1995




<PAGE>

                                                       EXHIBIT 23.4

              CONSENT OF KPMG PEAT MARWICK LLP, INDEPENDENT AUDITORS


We consent to incorporation by reference in the Registration Statement (Form
S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option Plan of
our report dated February 17, 1995, relating to the balance sheets of The
Biocine Company as of December 31, 1994 and 1993 and the related statements of
operations, partners' capital (deficit) and cash flows for each of the years in
the three year period ended December 31, 1994.

                                              KPMG PEAT MARWICK LLP



San Francisco, California
December 15, 1995



<PAGE>

                                                       EXHIBIT 23.5

        CONSENT OF RECONTA ERNST & YOUNG, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement
(Form S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option
Plan of our report dated February 28, 1995, with respect to the consolidated
financial statements of JV Vax B.V. and subsidiaries included in the Current
Report Form 8-K/A of Chiron Corporation dated January 4, 1995, as amended on
March 17, 1995, filed with the Securities and Exchange Commission.

                                            RECONTA ERNST & YOUNG



Milan, Italy
December 15, 1995



<PAGE>

                                                       EXHIBIT 23.6

              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement
(Form S-8) of Chiron Corporation pertaining to the Chiron 1991 Stock Option
Plan of our report dated February 8, 1995, except for Note 7, as to which the
date is April 26, 1995, with respect to the financial statements of Viagene,
Inc. included in the Current Report Form 8-K/A of Chiron Corporation dated
September 29, 1995, as amended on November 13, 1995, filed with the Securities
and Exchange Commission.

                                                    ERNST & YOUNG LLP



San Diego, California
December 15, 1995



<PAGE>

                         CHIRON 1991 STOCK OPTION PLAN
       [AS AMENDED AUGUST 14, 1993, APRIL 11, 1994 AND FEBRUARY 24, 1995]

I.  PURPOSES

    This  Chiron 1991  Stock Option Plan  ("Plan") is intended  to enable Chiron
Corporation ("Corporation") to attract and  retain the following individuals  by
offering them incentives and rewards, in the form of options, restricted shares,
share  rights, and share units ("awards") which will encourage them to acquire a
proprietary interest in the  Corporation and to continue  in the service of  the
Corporation   or  its  subsidiaries:  (a)   employees  (including  officers  and
directors) of the Corporation and its subsidiaries, (b) non-employee members  of
the  Board of  Directors of the  Corporation ("Board"), and  (c) consultants and
independent contractors who  perform valuable services  for the Corporation  and
its subsidiaries.

    In  addition, the Plan is intended to  permit the Corporation to satisfy its
obligations in connection with options it  will assume pursuant to the terms  of
the  Agreement and Plan  of Merger dated  as of July  21, 1991 by  and among the
Corporation,  Chiron  Acquisition  Subsidiary,   Inc.,  and  Cetus   Corporation
("Agreement").  Upon consummation of the transactions described in the Agreement
("Merger"), the Plan  will supersede  Cetus Corporation's  Amended and  Restated
Common  Stock Option Plan and  Cetus Corporation's Non-Employee Directors' Stock
Option Plan ("Cetus  Prior Plans").  Upon stockholder approval,  this Plan  will
also  supersede the  following Chiron prior  plans: the  Protos Corporation 1988
Stock  Option  Plan  (upon  the  merger  of  Protos  into  Chiron),  the  Chiron
Ophthalmics,  Inc. 1986 Stock Option Plan (upon the merger of Chiron Ophthalmics
into a wholly owned subsidiary of  Chiron), the Corporation's 1982 Stock  Option
Plan  and the Corporation's 1984  Non-Qualified Stock Option Plan (collectively,
"Chiron Prior Plans").

II.  ADMINISTRATION

    The Plan will be administered by a committee or committees appointed by  the
Board and consisting of one or more members of the Board. The Board may delegate
the  responsibility for  administration of the  Plan with  respect to designated
classes of award holders to different committees, subject to such limitations as
the Board deems appropriate. With respect  to any matter, the term  "Committee,"
when  used in  this Plan, will  refer to  the committee that  has been delegated
authority with respect  to such matter.  Members of a  committee will serve  for
such  term as  the Board may  determine, and will  be subject to  removal by the
Board at any time.

    (a)  16(B).  The composition of any committee responsible for administration
of the  Plan with  respect  to award  holders who  are  subject to  the  trading
restrictions  of Section  16(b) of  the Securities  Exchange Act  of 1934 ("1934
Act") with  respect  to securities  of  the  Corporation will  comply  with  the
applicable requirements of Rule 16b-3 of the Securities and Exchange Commission.

    (b)    AUTHORITY.   Any  committee appointed  by  the Board  will  have full
authority  to  administer   the  Plan   within  the  scope   of  its   delegated
responsibilities,  including authority  to interpret  and construe  any relevant
provision of  the Plan,  to adopt  such rules  and regulations  as it  may  deem
necessary,  and to determine the  terms and conditions of  awards made under the
Plan (which need  not be identical).  Decisions of a  committee made within  the
discretion delegated to it by the Board will be final and binding on all persons
who have an interest in the Plan.

III.  ELIGIBILITY FOR AWARDS

    (a)   DISCRETIONARY  AWARDS.  From  time to  time the Committee  may, in its
discretion, select individuals  from among the  following categories to  receive
awards under the Plan:

        (1)   EMPLOYEES.  The Committee  may select employees of the Corporation
    or its  subsidiaries  (including officers,  whether  or not  they  are  also
    members of the Board).

                                      A-1
<PAGE>
        (2)   CONSULTANTS AND INDEPENDENT CONTRACTORS.  The Committee may select
    consultants and independent  contractors whose services  tend to  contribute
    materially  to the success  of the Corporation or  its subsidiaries or whose
    services may reasonably be anticipated to so contribute.

    (b)  AUTOMATIC GRANTS.   Members of the Board who  are not employees of  the
Corporation  or its  subsidiaries will receive  options in  accordance with, and
only in accordance with, the Plan's automatic grant provisions.

    (c)   SUBSTITUTE OPTIONS.    Upon consummation  of the  Merger,  outstanding
options   under  the  Cetus   Prior  Plans  (including   related  Limited  Stock
Appreciation Rights) will be converted, in the manner and at the exchange  ratio
specified  in the Agreement, into substitute  options under this Plan to acquire
Common Stock (as defined below). Upon  stockholder approval and, with regard  to
the  Protos prior  plan options and  the Chiron Ophthalmics  prior plan options,
consummation of the relevant mergers, outstanding options under the Chiron Prior
Plans will  be  converted into  options  under  this Plan.  These  options  will
preserve  the exercise price of the outstanding options as adjusted, in the case
of options under the  Protos Corporation 1988 Stock  Option Plan and the  Chiron
Ophthalmics,  Inc. 1986 Stock Option Plan, to reflect the substitution of Common
Stock. These options will  also preserve the other  terms and conditions of  the
outstanding options; provided, however, that on the Effective Date of this Plan,
outstanding  automatic option grants  under the Corporation's  1982 Stock Option
Plan will be conformed, other than to  extend the term, to the Automatic  Option
Grants under this Plan. Collectively, these options will be known as "Substitute
Options."

IV.  STOCK SUBJECT TO THE PLAN

    (a)    CLASS.   The  stock  subject to  awards  under  the Plan  is  (i) the
Corporation's authorized  but  unissued  or  reacquired  Common  Stock  ("Common
Stock"),  or (ii) shares of  one or more series  of the Corporation's authorized
but unissued or reacquired Restricted  Common Stock, in the aggregate,  "Company
Stock."  In connection with the grant of  awards under the Plan, the Corporation
may repurchase shares in the open market or otherwise.

    (b)  AGGREGATE AMOUNT

        (1)  SHARES.  Subject to  adjustment under Sections IV(c) and  IV(b)(3),
    the  aggregate maximum number of shares of Company Stock that may be subject
    to awards under the Plan is 4,500,000  plus the number of shares of  Company
    Stock  remaining for issuance on  the Effective Date of  this Plan under the
    Corporation's  1982   Stock  Option   Plan   and  the   Corporation's   1984
    Non-Qualified  Stock  Option  Plan.  Notwithstanding  the  foregoing,  as of
    January 1 of each fiscal year after 1991, the aggregate number of shares  of
    Company Stock that may be subject to awards under the Plan will be increased
    by  1.50% of the number of Chiron Common Equivalent Shares outstanding as of
    December 31 of the  preceding fiscal year. The  maximum number of shares  of
    Company  Stock with respect to which options  may be granted to any employee
    during the term of the Plan is 1,000,000 shares. Subject to adjustment under
    Sections IV(c) and IV(b)(3), not more than 4,500,000 shares of Company Stock
    plus the number  of shares of  Company Stock remaining  for issuance on  the
    Effective  Date of this Plan under  the Corporation's 1982 Stock Option Plan
    and the Corporation's 1984 Non-Qualified Stock Option Plan may be subject to
    Incentive Options  (as  defined below)  granted  under the  Plan  after  the
    Effective  Date. "Chiron Common  Equivalent Shares" are  the total number of
    outstanding shares of Common Stock plus the total number of shares of Common
    Stock issuable upon conversion or exercise of outstanding warrants,  options
    and  convertible securities.  In no event  will more than  500,000 shares of
    Restricted Common Stock, whether in a  single series or in multiple  series,
    be subject to award under the Plan.

        (2)   RESTRICTED COMMON STOCK.  Shares of Restricted Common Stock may be
    issued  under  the  Plan  in  one  or  more  separate  series.  The  rights,
    preferences  and privileges, together with  the restrictions and limitations
    and the number of shares, of each series of Restricted Common Stock issuable
    under the  Plan  will be  set  forth  in the  Corporation's  Certificate  of
    Determination  of Preferences of  Common Stock ("Certificate")  as in effect
    from time to  time during the  term of the  Plan. Shares of  each series  of
    Restricted  Common Stock will be convertible  or exchangeable into shares of
    Common Stock in accordance with the terms and provisions of the  Certificate
    applicable to that series.

                                      A-2
<PAGE>
        (3)   REUSE OF SHARES.  If any outstanding option under the Chiron Prior
    Plans, the Cetus Prior Plans or this Plan (including the Substitute Options)
    expires or is terminated or cancelled for any reason (including pursuant  to
    Section X of the Plan but other than pursuant to surrender of the option for
    a  cash payment in  accordance with Section  XIII of the  Plan) before being
    exercised for the full number of shares to which it applies, then the shares
    allocable to the  unexercised portion  of such  option will  not be  charged
    against  the limitations of  Section IV(b)(1) and  will become available for
    subsequent grants under the Plan. To the extent that a share right or  share
    unit  expires or is terminated,  or is canceled or  forfeited for any reason
    without being paid in cash or shares of Company Stock, any remaining  shares
    allocable  to the unpaid portion of such share right or share unit shall not
    be charged  against the  limitations  of Section  IV(b)(1) and  will  become
    available  again for subsequent grants under the Plan. Shares subject to any
    option or portion of an option surrendered in accordance with the "Surrender
    of Options for Cash or  Stock" provisions of this  Plan, shares for which  a
    cash payment is made in lieu thereof under a restricted share, share unit or
    share  right,  and shares  forfeited to  or  repurchased by  the Corporation
    pursuant to its forfeiture and repurchase rights under this Plan will not be
    available for subsequent awards under the Plan.

    (c)  ADJUSTMENTS.   In the  event any change  is made to  the Company  Stock
subject to the Plan (whether by reason of merger, consolidation, reorganization,
recapitalization,  stock dividend, stock split,  combination of shares, exchange
of shares, or other change in corporate or capital structure of the Corporation)
then, unless such change results in the termination of all awards, the Committee
will make  appropriate adjustments  to the  kind and  maximum number  of  shares
subject to the Plan, the kind and maximum number of shares for which options are
to  be granted to non-employee directors, and the kind and number of shares and,
where applicable, price per share of stock subject to outstanding awards.

V.  TERMS AND CONDITIONS OF OPTIONS

    Stock options granted under the Plan may, in the Committee's discretion,  be
either  incentive stock  options ("Incentive Options")  qualifying under Section
422 of the Internal Revenue Code of 1986, as amended ("Internal Revenue  Code"),
or nonstatutory options. Individuals who are not employees of the Corporation or
its  subsidiaries  may only  be granted  nonstatutory  options. Options  will be
evidenced by instruments in  such form as  the Committee may  from time to  time
approve.  These instruments will  conform to the  following terms and conditions
and, in  the  discretion  of  the  Committee,  may  contain  such  other  terms,
conditions and restrictions as are not inconsistent with the following:

    (a)    OPTION PRICE.    The option  price  per share  will  be fixed  by the
Committee, but  in  no event  will  the option  price  per share  be  less  than
eighty-five  percent (85%) of the Fair Market  Value of the option shares on the
date of the option grant;  provided, however, that in  no event will the  option
price  per share of an Incentive Option  be less than one-hundred percent (100%)
of the Fair Market Value of the option  shares on the date of the option  grant.
Notwithstanding  the foregoing, Substitute Options will have an option price per
share determined pursuant to Section III(c)  of this Plan and interim  Automatic
Option Grants will have an option price per share determined pursuant to Section
VII(a)(3) of the Plan.

    (b)  NUMBER OF SHARES, TERM AND EXERCISE

        (1)    TERM AND  NUMBER.   Each option  granted under  the Plan  will be
    exercisable on such date or dates,  during such period, and for such  number
    of shares of Company Stock as the Committee determines and sets forth in the
    instrument evidencing the option. No option granted under the Plan will have
    an  expiration date that is more than 10  years after the date of the option
    grant.

        (2)   EXERCISE.    After  any option  granted  under  the  Plan  becomes
    exercisable,  it may be exercised  by notice to the  Corporation at any time
    prior to  the  termination of  such  option.  Except as  authorized  by  the
    Committee  in accordance with Section VIII,  the option price for the number
    of shares for which the option is exercised will become due and payable upon
    exercise.

                                      A-3
<PAGE>
        (3)   PAYMENT.   The  option  price will  be  payable in  full  in  cash
    (including  cash equivalents);  provided, however,  that the  Committee may,
    either at the time the option is granted or at the time it is exercised  and
    subject to such limitations as it may determine, authorize payment of all or
    a  portion of  the option  price in  one or  a combination  of the following
    alternative forms:

           (i) a promissory note authorized pursuant to Section VIII;

           (ii) full payment in shares of Common Stock valued as of the exercise
       date and  held  for  the  requisite  period to  avoid  a  charge  to  the
       Corporation's earnings; or

          (iii) by delivery of a properly executed exercise notice together with
       irrevocable   instructions  to  a  broker  to  promptly  deliver  to  the
       Corporation the amount of sale or loan proceeds to pay the option price.

    (c)  TERMINATION OF SERVICES.  The Committee will determine and set forth in
each option whether the  option will continue to  be exercisable, and the  terms
and  conditions of such exercise, on and  after the date that an optionee ceases
to  be  employed  by,  or  to  provide  services  to,  the  Corporation  or  its
subsidiaries.  The date of  termination of an  optionee's employment or services
will be determined by the Committee, which determination will be final.

    (d)  INCENTIVE OPTIONS.  Options granted under the Plan that are intended to
be Incentive  Options will  be subject  to the  following additional  terms  and
conditions:

        (1)   DOLLAR LIMITATION.   To the extent that  the aggregate Fair Market
    Value (determined as  of the respective  date or dates  of grant) of  shares
    with  respect to which  options that are  granted after 1986  and that would
    otherwise be Incentive  Options are exercisable  for the first  time by  any
    individual during any calendar year under the Plan (or any other plan of the
    Corporation,  a  parent or  subsidiary  corporation or  predecessor thereof)
    exceeds the sum  of $100,000  (or such greater  amount as  may be  permitted
    under  the  Internal Revenue  Code), whether  by  reason of  acceleration or
    otherwise, such options will not be treated as Incentive Options. In  making
    such  a determination, options  will be taken  into account in  the order in
    which they  were  granted.  The  aggregate fair  market  value  (as  of  the
    respective  date or dates of  grant) of shares of  the Company (or parent or
    subsidiary corporation) for which Incentive Options could be granted to  any
    one  individual  in a  single  calendar year  before  1987 could  not exceed
    $100,000 at the time of grant,  plus unused carryovers from the  immediately
    preceding three calendar years.

        (2)  10% STOCKHOLDER.  If any employee to whom an Incentive Option is to
    be  granted pursuant to the provisions of the Plan is, on the date of grant,
    the owner of stock (determined with application of the ownership attribution
    rules of Section 424(d) of the  Internal Revenue Code) possessing more  than
    ten percent (10%) of the total combined voting power of all classes of stock
    of  his  or  her  employer  corporation  or  of  its  parent  or  subsidiary
    corporation ("10% Stockholder"), then the following special provisions  will
    apply to the option granted to such individual:

           (i) The option price per share of the stock subject to such Incentive
       Option  will not be less than one  hundred ten percent (110%) of the Fair
       Market Value of the option shares on the date of grant; and

           (ii) The option will not have a term in excess of five (5) years from
       the date of grant.

        (3)  SEQUENTIAL EXERCISE.  No Incentive Option granted before January 1,
    1987 may be exercised  while there remains  outstanding any other  Incentive
    Option  to  purchase shares  of  the Company  (or  its parent  or subsidiary
    corporation) which was granted at an earlier date to the optionee.

        (4)  PARENT AND SUBSIDIARY.   For purposes of this Section V(d)  "parent
    corporation"  and "subsidiary corporation" will  have the meaning attributed
    to those terms, as they are used  in Section 422(b) of the Internal  Revenue
    Code.

                                      A-4
<PAGE>
    (e)  WITHHOLDING

        (1)    OBLIGATION.    The  Corporation's  obligation  to  deliver  stock
    certificates upon the exercise  of an option will  be subject to the  option
    holder's  satisfaction of all applicable federal, state and local income and
    employment tax withholding requirements.

        (2)  PAYMENT.  In the event that an option holder is required to pay  to
    the  Corporation  an  amount  with  respect  to  income  and  employment tax
    withholding obligations  in  connection  with exercise  of  an  option,  the
    Committee  may, in its discretion and  subject to such limitations and rules
    as it may  adopt, permit  the option holder  to satisfy  the obligation,  in
    whole  or in part, by delivering shares  of Common Stock already held by the
    option holder or  by making an  irrevocable election that  a portion of  the
    total  value of the shares subject to the option be paid in the form of cash
    in lieu of  the issuance of  Company Stock,  and that such  cash payment  be
    applied to the satisfaction of the withholding obligations.

VI.  RESTRICTED SHARES, SHARE RIGHTS AND SHARE UNITS

    (a)  NATURE OF AWARDS

        (1)  RESTRICTED SHARES.  A restricted share granted under the Plan shall
    consist  of shares of Company Stock, the  retention and transfer of which is
    subject to  such  terms,  conditions  and  restrictions  (whether  based  on
    performance  standards  or periods  of  service or  otherwise  and including
    repurchase and/or  forfeiture rights  in favor  of the  Corporation) as  the
    Committee  shall determine. The terms,  conditions and restrictions to which
    restricted shares are subject shall be evidenced by instruments in such form
    as the Committee may from  time to time approve and  may vary from grant  to
    grant. The Committee shall have the absolute discretion to determine whether
    any consideration (other than the services of the potential award holder) is
    to  be  received  by the  Corporation  or  its subsidiaries  as  a condition
    precedent to the issuance of restricted shares.

        (2)  SHARE RIGHTS.  A share  right granted under the Plan shall  consist
    of  the right, subject  to such terms,  conditions and restrictions (whether
    based on  performance standards  or  periods of  service or  otherwise),  to
    receive a share of Company Stock (together with cash dividend equivalents if
    so  determined by the Committee) as  the Committee shall determine and shall
    be evidenced by instruments in such form  as the Committee may from time  to
    time  approve. The Committee shall have the absolute discretion to determine
    whether any consideration (other  than the services  of the potential  award
    holder)  is  to be  received by  the  Corporation or  its subsidiaries  as a
    condition precedent to the issuance of shares pursuant to share rights.  The
    terms,  conditions and  restrictions to which  share rights  are subject may
    vary from grant to grant.

        (3)  SHARE UNITS.  A share unit granted under the Plan shall consist  of
    the right to receive an amount in cash equal to the fair market value of one
    share  of Company Stock on the date  of valuation of the unit (together with
    cash dividend  equivalents if  so  determined by  the Committee)  less  such
    amount,  if any, as the  Committee shall specify. The  date of valuation and
    payment of cash under a share unit and the conditions, if any, to which such
    payment will be subject (whether  based on performance standards or  periods
    of  service or otherwise)  shall be determined by  the Committee. The terms,
    conditions and restrictions to which share  units are subject may vary  from
    grant to grant.

    (b)   WITHHOLDING.  The Committee may  require, or permit an award holder to
elect, that a portion of the total  value of the shares of Common Stock  subject
to  restricted shares or share rights held by  one or more award holders be paid
in the form of cash in lieu of the issuance of Company Stock and that such  cash
payment  be applied to the  satisfaction of the federal,  state and local income
and employment tax withholding obligations that arise at the time the restricted
shares and share rights become free of all restrictions under the Plan.

    (c)   CASH  PAYMENTS.   The  Committee may  provide  award holders  with  an
election to receive a percentage of the total value of the Company Stock subject
to  restricted shares or share rights in the  form of a cash payment, subject to
such terms, conditions and restrictions as the Committee shall specify.

                                      A-5
<PAGE>
    (d)  ELECTIVE AND TANDEM AWARDS.  The Committee may award restricted shares,
share rights and share units independently  of other compensation or in lieu  of
compensation  that would otherwise be paid in  cash or stock options, whether at
the election  of  the  potential  award  holder  or  otherwise.  The  number  of
restricted shares, share rights or share units to be awarded in lieu of any cash
compensation  amount  or number  of  stock options  shall  be determined  by the
Committee in  its  sole  discretion and  need  not  be equal  to  such  foregone
compensation  in fair market value. In addition, restricted shares, share rights
and share units may be awarded in  tandem with stock options, so that a  portion
of such award becomes payable or becomes free of restrictions only if and to the
extent  that the tandem options  are not exercised or  are forfeited, subject to
such terms and conditions as the Committee may specify.

    (e)  MODIFICATION  OF AWARDS.   The Committee may,  in its sole  discretion,
modify  or waive any or all of  the terms, conditions or restrictions applicable
to any  outstanding  restricted share,  share  right or  share  unit;  provided,
however,  that no such modification or waiver  shall, without the consent of the
holder of an outstanding award, adversely affect the holder's rights thereunder.

VII.  AUTOMATIC OPTION GRANTS TO DIRECTORS

    (a)   GRANTS.   Non-employee  members of  the  Board will  automatically  be
granted  nonstatutory options ("Automatic Option Grants") to purchase the number
of shares of Common Stock set  forth below (subject to adjustment under  Section
IV(c) hereof) on the dates and terms set forth below:

        (1)   CONTINUING  DIRECTORS.   On the  last business  day of  the second
    quarter of each fiscal year of  the Corporation after the Effective Date  of
    this  Plan ("Automatic Grant Date"),  each continuing non-employee member of
    the Board will receive an Automatic Option Grant to purchase 3,000 shares of
    Common Stock.

        (2)  NEW DIRECTORS.  Each person who is newly elected or appointed as  a
    non-employee  member  of the  Board after  the Effective  Date of  this Plan
    (other than on an Automatic  Grant Date) will receive,  on the date of  such
    election  or appointment, an  Automatic Option Grant to  purchase a pro rata
    number of shares of Common Stock. The pro rata number will be determined  by
    multiplying  250 by the number of whole  calendar months between the date of
    the non-employee director's election or  appointment and the next  Automatic
    Grant Date.

        (3)   INTERIM GRANTS.  Non-employee members  of the Board who were newly
    elected or appointed  between July 1,  1990 and the  Effective Date of  this
    Plan received grants under this Section VII(a) on the Effective Date of this
    Plan  for a pro  rata number of  shares calculated as  though the grant were
    made on the date that the non-employee member of the Board was newly elected
    or appointed ("Interim Grants"). The  terms and conditions of these  Interim
    Grants  will be  determined under Section  VII(b) below, as  though the date
    that the non-employee member was elected or appointed was the grant date and
    as though the  date that the  non-employee member of  the Board received  an
    automatic  grant (if any) under the Corporation's 1982 Stock Option Plan was
    an Automatic Grant Date under this Plan.

        (4)   ADVISORY COUNSELLORS.    Advisory Counsellors  of Cetus  will  not
    qualify for Automatic Option Grants.

    (b)   TERMS  AND CONDITIONS.   The terms  and conditions  applicable to each
Automatic Option Grant will be as follows:

        (1)  PRICE.   The option price  per share will be  equal to one  hundred
    percent  (100%) of the Fair Market Value of one share of Common Stock on the
    date of grant;

        (2)  TERM.  The options will have terms of (10) years, measured from the
    date of grant, and will be exercisable at any time during their term for all
    or any part of the covered shares; provided, however, that no options may be
    exercised prior to approval of the Plan by the Corporation's stockholders.

        (3)  REPURCHASE.  The shares purchased under the options will be subject
    to repurchase by the Corporation at the original exercise price in the event
    an  optionee  ceases  to  provide   services  to  the  Corporation  or   its
    subsidiaries  as a  director, an  employee, a  consultant or  an independent
    contractor.

                                      A-6
<PAGE>
    The Corporation's repurchase rights will lapse, and the optionee's  interest
    in  the purchased shares will vest, in a series of equal annual installments
    over the five-year  period measured  from the  date of  grant; provided  the
    optionee  continues to provide such services. In addition, the Corporation's
    repurchase right will lapse  in its entirety, and  full vesting will  occur,
    should  one or  more of  the following  events occur  while the  optionee is
    providing such services:  (A) the  optionee's death, or  (B) the  optionee's
    permanent disability.

        (4)   PAYMENT.   Upon exercise of  the option, the  option price for the
    purchased shares will  become payable immediately  in cash or  in shares  of
    Common Stock that the optionee has held for at least six (6) months. Payment
    may also be made by delivery of a properly executed exercise notice together
    with  irrevocable  instructions  to  a broker  to  promptly  deliver  to the
    Corporation the amount of sale or loan proceeds to pay the option price.

        (5)  CESSATION.  In the event the optionee ceases to provide services to
    the Corporation or its subsidiaries as a director, an employee, a consultant
    or an independent contractor, the option  may be exercised, within the  term
    of  the option,  for a  period of three  (3) months  after the  date of such
    cessation (twelve  (12)  months  in  the case  of  cessation  by  reason  of
    disability  or death).  In the  case of death,  the option  may be exercised
    within such period by the estate or heirs of the optionee.

VIII.  LOANS AND INSTALLMENT PAYMENTS

    In order to assist an award holder (including an employee who is an  officer
or  director of the Corporation)  in the acquisition of  shares of Company Stock
pursuant to  an  award  granted under  the  Plan  (other than  pursuant  to  the
Automatic Option Grant provisions of this Plan), the Committee may authorize, at
either  the time  of the grant  of an  award or the  time of  the acquisition of
Company Stock pursuant to  the award (i)  the extension of a  loan to the  award
holder  by the Corporation, (ii) the payment by the award holder of the purchase
price, if any, of the Company Stock  in installments, or (iii) the guarantee  by
the  Corporation of a loan obtained by the  award holder from a third party. The
terms of any loans, guarantees  or installment payments, including the  interest
rate and terms of repayment, will be subject to the discretion of the Committee.
Loans,  installment payments and guarantees may be granted without security, the
maximum credit available being the purchase price, if any, of the Company  Stock
acquired  plus the maximum federal and state income and employment tax liability
that may be incurred in connection with the acquisition.

IX.  ASSIGNABILITY

    No award granted under the Plan  is assignable or transferable by the  award
holder other than by Will or by the laws of descent and distribution, and during
the  lifetime of the award holder, only the award holder may exercise options or
exercise the rights provided under awards granted under the Plan.

X.  CANCELLATION AND NEW GRANT OF OPTIONS

    The Committee will have the authority to  effect, at any time and from  time
to  time, with the consent  of the affected option  holders, the cancellation of
any or all outstanding options  under the Plan, a Cetus  Prior Plan or a  Chiron
Prior  Plan (other than options granted  under automatic option grant provisions
of these plans) and to grant in substitution therefor new options under the Plan
covering the same or different numbers of shares, but having an option price per
share not less than eighty-five  percent (85%) of the  Fair Market Value on  the
new  grant date  or, in  the case  of an  Incentive Option,  one hundred percent
(100%) of the Fair  Market Value on the  new grant date (or,  in the case of  an
Incentive Option granted to a 10% Stockholder, one hundred ten percent (110%) of
such Fair Market Value). If one or more of the cancelled options is an Incentive
Option granted before 1987 under a Cetus Prior Plan or a Chiron Prior Plan, then
such  option  will,  solely  for  purposes  of  the  "sequential  exercise" rule
applicable to outstanding Incentive Options  granted before 1987, be  considered
to  be outstanding until the expiration  date initially specified for the option
term of such option.

XI.  ACCELERATION AND TERMINATION OF AWARDS

    (a)   ACCELERATION.   In the  event of  an agreement  to dispose  of all  or
substantially  all of the assets or outstanding capital stock of the Corporation
by means of a sale, merger,  reorganization, or liquidation, each award will  be
automatically  accelerated  so that  (1) options  become fully  exercisable with
respect to the total

                                      A-7
<PAGE>
number of  shares purchasable  under the  options, provided,  however, that  the
exercise  of accelerated  Incentive Options  granted prior  to 1987  will remain
subject to any  limitations imposed  by the Internal  Revenue Code's  sequential
exercise rule, (2) restrictions on restricted shares will be eliminated, and the
shares  will  immediately  vest,  and  (3) share  rights  and  share  units will
immediately vest and  become payable.  The Committee  may also  provide for  the
automatic termination of repurchase rights upon the occurrence of such an event.

    (b)   NO ACCELERATION.  No acceleration of awards will occur if the terms of
the agreement require as  a prerequisite to the  consummation of any such  sale,
merger,  reorganization  or  liquidation that  each  such award  will  be either
assumed by the  successor corporation or  parent thereof or  be replaced with  a
comparable  award  subject  to shares  of  the successor  corporation  or parent
thereof. The determination of such comparability will be made by the  Committee,
and  its determination will be final,  binding and conclusive. Upon consummation
of  the  sale,  merger,  reorganization  or  liquidation  contemplated  by   the
agreement, all awards, whether or not accelerated, will terminate unless assumed
pursuant to a written agreement by the successor corporation or parent thereof.

    (c)   CORPORATE STRUCTURE.   The grant of awards under  this Plan will in no
way affect the right  of the Corporation to  adjust, reclassify, reorganize,  or
otherwise  change its  capital or business  structure or  to merge, consolidate,
dissolve, liquidate or  sell or  transfer all  or any  part of  its business  or
assets.

XII.  VALUATION

    With  regard to all Substitute Options, Fair Market Value will be determined
in accordance  with the  relevant option  plan documents  on the  date that  the
outstanding options were granted. With regard to awards granted under this Plan,
for  all valuation purposes under the Plan, the  Fair Market Value of a share of
Common Stock or Restricted  Common Stock (as  the case may  be) on any  relevant
date will be determined in accordance with the following provisions:

    (a) If the Common Stock or Restricted Common Stock is not at the time listed
or   admitted  to  trading  on  any  stock   exchange,  but  is  traded  in  the
over-the-counter market, the Fair Market Value  will be the average between  the
reported  high price and the reported low price  of one share of Common Stock or
Restricted Common Stock  (as the case  may be) on  the date in  question in  the
over-the-counter market, as such prices are reported by the National Association
of Securities Dealers through its NASDAQ system or any successor system.

    (b)  If the Common Stock or Restricted Common Stock is at the time listed or
admitted to trading on any  stock exchange, then the  Fair Market Value will  be
the  average between the reported  high price and the  reported low price of one
share of Common Stock  or Restricted Common  Stock (as the case  may be) on  the
date in question on the stock exchange that is the primary market for the stock,
as such prices are officially quoted on such exchange.

    (c)  If the Common Stock or Restricted Common  Stock (as the case may be) is
at the time neither  listed nor admitted  to trading on  any stock exchange  nor
traded  in  the over-the-counter  market, or  if  the Committee  determines that
neither subparagraph (a) nor subparagraph  (b) above reflects Fair Market  Value
of  the stock  and the award  was not  granted pursuant to  the Plan's Automatic
Option Grant provisions, then  the Fair Market Value  will be determined by  the
Committee  after  taking  into  account  such  factors  as  the  Committee deems
appropriate, or in the case of Automatic Option Grants, by an independent  third
party valuation.

XIII.  SURRENDER OF OPTIONS FOR CASH OR STOCK

    (a)   STOCK  APPRECIATION RIGHTS.   If,  and only  if the  Committee, in its
discretion, elects to implement an option surrender program under the Plan,  one
or  more option holders may, upon such terms and conditions as the Committee may
establish at the time of the option grant or at any time thereafter, be  granted
the  right to surrender all  or part of an unexercised  option in exchange for a
distribution equal in amount to the difference between (i) the Fair Market Value
(at date of surrender) of the shares for which the surrendered option or portion
thereof is at the time exercisable  and (ii) the aggregate option price  payable
for  such shares.  The distribution to  which an option  holder becomes entitled
under this Section may be made in

                                      A-8
<PAGE>
shares of Common Stock or Restricted  Common Stock, valued at Fair Market  Value
at  the date of surrender, in  cash, or partly in shares  and partly in cash, as
the Committee, in its sole  discretion, deems appropriate. The option  surrender
provisions  of this Section  will not apply  to options granted  pursuant to the
Automatic Option Grant provisions of this Plan.

    (b)  LIMITED STOCK APPRECIATION RIGHTS.  If outstanding options of Cetus for
which Substitute  Options are  issued pursuant  to Section  III(c) have  Limited
Stock  Appreciation Rights ("LSARs") attached thereto, then each such LSAR shall
be  honored  by  the  Corporation  in  accordance  with  its  terms  and  remain
exercisable  for a  period of  60 days following  the date  that stockholders of
Cetus approve the  Merger; provided, however,  that if the  LSAR was  originally
granted  within 6 months of the date that Cetus stockholders approve the Merger,
then the LSAR will be exercisable for  a period of 60 days following  expiration
of  such 6-month period. Upon  expiration of the applicable  60 day period, each
such LSAR not previously exercised shall  expire. Upon exercise of an LSAR,  the
related  option will  be cancelled, and  Chiron will  pay to the  LSAR holder an
amount in  cash for  each share  with respect  to which  the LSAR  is  exercised
determined in accordance with the terms of the Cetus Prior Plans.

XIV.  REPURCHASE RIGHTS

    The  Committee may, in  its discretion, establish  as a term  of one or more
awards granted under the  Plan that the Corporation  (or its assigns) will  have
the  right, exercisable upon the award  holder's termination of employment with,
or  cessation  of  services  for,  the  Corporation  and  its  subsidiaries,  to
repurchase  at the original price  paid, if any, for  such shares of (1) Company
Stock acquired by the award holder pursuant to the granted award, or (2)  Common
Stock into which acquired Restricted Common Stock may have been converted or for
which Restricted Common Stock may have been exchanged. Any such repurchase right
will  be exercisable  by the  Corporation (or its  assigns) upon  such terms and
conditions (including provisions for the expiration of such right in one or more
installments) as the  Committee may  specify in the  instrument evidencing  such
right.  The Committee will also have full power and authority to provide for the
automatic termination of  the Corporation's  repurchase rights, in  whole or  in
part,  thereby accelerating the  vesting of any  or all of  the purchased shares
(other than purchased  shares obtained  pursuant to the  Automatic Option  Grant
provisions  of this Plan) upon the occurrence of any change in control specified
in Article XI.

XV.  RIGHT OF FIRST REFUSAL

    The Committee may, in  its discretion, establish  as a term  of one or  more
awards  granted under the Plan that the Corporation has a right of first refusal
with respect to the proposed disposition  by the award holder (or any  successor
in interest by reason of purchase, gift or other mode of transfer) of any shares
of (1) Company Stock acquired by the award holder pursuant to the granted award,
or  (2) Common Stock into which purchased  Restricted Common Stock may have been
converted or for which acquired Restricted Common Stock may have been exchanged.
Any such right of first  refusal will be exercisable  by the Corporation or  its
assigns  in accordance with the terms and conditions specified in the instrument
evidencing such right.

XVI.  EFFECTIVE DATE AND TERM OF PLAN

    (a)  EFFECTIVE DATE.  The Plan is effective on the date that it is  approved
by the Corporation's stockholders.

    (b)   TERM.  Incentive Options may be granted under the Plan only within ten
years of  the  Effective Date  of  the Plan.  Subject  to this  limitation,  the
Committee  may grant awards under the Plan  at any time after the Effective Date
of the Plan and before the Plan is terminated by the Board.

XVII.  AMENDMENT OR DISCONTINUANCE

    (a)  BOARD.  The Board may  amend, suspend or discontinue the Plan in  whole
or  in  part at  any  time; provided,  however, that  (a)  except to  the extent
necessary to qualify as Incentive Options  any or all options granted under  the
Plan  that are intended to so qualify,  such action may not, without the consent
of the award  holder, adversely affect  rights and obligations  with respect  to
awards outstanding under the Plan; (b) the provisions of the Plan concerning the
eligibility  of non-employee  members of  the Board  for awards  and the amount,
price and timing of Automatic Option Grants  under this Plan may not be  amended
more than once

                                      A-9
<PAGE>
every  six months, other  than to comport  with changes in  the Internal Revenue
Code or rules thereunder; and (c) the Board may not, without the approval of the
Corporation's stockholders  (1)  materially increase  the  number of  shares  of
Company  Stock subject to awards under the  Plan (unless necessary to effect the
adjustments required under Section IV(c)), (2) materially modify the eligibility
requirements for  awards under  the Plan,  or  (3) make  any other  change  with
respect  to which the Board determines  that stockholder approval is required by
applicable law or regulatory standards.

    (b)  COMMITTEE.  The Committee will have full power and authority to  modify
or  waive any or all of the  terms, conditions or restrictions applicable to any
outstanding award  (other  than Automatic  Option  Grants), to  the  extent  not
inconsistent with the Plan.

    (c)  SUBSTITUTE OPTIONS.  Substitute Options will be subject to amendment in
accordance with the terms of this Plan.

XVIII.  NO OBLIGATION

    Nothing  contained in the Plan  (or in any award  granted under this Plan, a
Chiron Prior  Plan  or a  Cetus  Prior Plan)  shall  confer upon  any  employee,
consultant, or independent contractor any right to continue in the employ of, or
to  provide  services  to, the  Corporation  or  any affiliate  or  constitute a
contract or  agreement  of employment  or  for  the provision  of  services,  or
interfere in any way with the right of the Corporation or an affiliate to reduce
such  employee's, consultant's or independent contractor's compensation from the
rate in existence at the time of the  granting of an award or to terminate  such
employee's,  consultant's or independent contractor's  employment or services at
any time, with or  without cause; but  nothing contained in the  Plan or in  any
award granted under this Plan shall affect any contractual rights of an employee
pursuant to a written employment agreement.

XIX.  USE OF PROCEEDS

    The  cash proceeds  received by the  Corporation pursuant  to awards granted
under the Plan will be used for general corporate purposes.

XX.  COMPLIANCE

    (a)   FEDERAL  AND  STATE  LAWS.   No  option  may  be  exercised,  and  the
Corporation  will not be obligated to issue stock under any award unless, in the
opinion of  counsel  for the  Corporation,  such  exercise and  issuance  is  in
compliance with all applicable federal and state securities laws. As a condition
to  the grant of  any award, or  to the issuance  of stock under  any award, the
Committee may require that the award holder agree to comply with such provisions
of federal and state securities laws as  may be applicable to such grant, or  to
the  sale of  stock acquired  pursuant to  the Plan,  and that  the award holder
deliver  to  the  Corporation  a  written  agreement,  in  form  and   substance
satisfactory to the Corporation and its counsel, implementing such agreement.

    (b)    INFORMATION.   The  Corporation  will  furnish to  each  award holder
participating in the Plan (other  than a key employee or  a director) a copy  of
the Corporation's Annual Report to Stockholders for the most recent fiscal year,
and  additional copies will be furnished,  without charge, to such award holders
upon request to the Secretary of the Corporation.

                                      A-10
<PAGE>
                                   APPENDIX A
           SPECIAL PROVISIONS RELATED TO 1995 CIBA-GEIGY TRANSACTION

    Those persons holding options  to acquire shares of  Common Stock under  the
Corporation's  1991  Stock Option  Plan  on November  20,  1994 are  granted the
following rights ("Rights") with respect to each such option:

    (i) the right to receive upon  the closing of the tender offer  contemplated
under  the Investment Agreement entered into  on such date among the Corporation
and Ciba-Geigy  Limited, Ciba-Geigy  Corporation and  Ciba Biotech  Partnership,
Inc.  (the "Closing") a cash payment equal to (A) 37.33% of the number of shares
of Common  Stock with  respect to  which  each such  option would  first  become
exercisable  in calendar year 1995 multiplied by (B) the difference between $117
per share and the exercise price per  share of such option with respect to  such
shares and

    (ii)  with respect to the  remaining shares of Common  Stock subject to each
such option, the right, exercisable at any  time after the later of the  Closing
or  the date that such an option  first becomes exercisable with respect to such
shares, to surrender  that portion  of such option  relating to  37.33% of  such
shares in return for a cash payment equal (A) to the difference between $117 per
share  and the  exercise price per  share of  such option multiplied  by (B) the
number of shares with respect to  which such option is so surrendered.  However,
the grant and exercise of any such right with respect to any officer or director
subject to Section 16 of the Securities Exchange Act of 1934 shall be subject to
stockholder  approval  of the  grant of  such rights  at the  Corporation's 1995
stockholder meeting. The grant  of such rights, which  are made with respect  to
1,858,776  optioned shares shall be in addition to, and shall not count against,
the aggregate and annual limits  on the number of  shares with respect to  which
other  awards under  the Plan  may be  made to  all individuals  and/or a single
individual.

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