CHIRON CORP
S-8, 1996-08-19
PHARMACEUTICAL PREPARATIONS
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<PAGE>

      As filed with the Securities and Exchange Commission on August 19, 1996
                                                                         
                                                 Registration No. 33-
                                                                    -----------

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549

                               -----------------------

                                       FORM S-8
                               REGISTRATION STATEMENT
                                        UNDER
                              THE SECURITIES ACT OF 1933

                                  ------------------

                                  CHIRON CORPORATION
                  (EXACT NAME OF ISSUER AS SPECIFIED IN ITS CHARTER)

              Delaware                              94-2754624
    (State or other jurisdiction of              (I.R.S. Employer
    incorporation or organization)               Identification No.)

                    4560 Horton St., Emeryville, California 94608
                                    (510) 655-8730
            (Address, including zip code, and telephone number, including
               area code, of registrant's principal executive offices)

                                  ------------------

                            CHIRON 1991 STOCK OPTION PLAN
                               (Full title of the plan)

                                 -------------------

                               EDWARD E. PENHOET, PH.D.
                        President and Chief Executive Officer
                                  CHIRON CORPORATION
                   4560 Horton Street, Emeryville, California 94608
                                    (510) 655-8730
              (Name, address, including zip code, and telephone number,
                      including area code, of agent for service)

                           CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
 
- -----------------------------------------------------------------------------------------------------------------
Title of Securities                              Proposed Maximum          Proposed Maximum           Amount of
 to be Registered    Amount to be Registered  Offering Price Per Share  Aggregate Offering Price  Registration Fee
 ----------------    -----------------------  ------------------------  ------------------------  ----------------
<S>                  <C>                      <C>                       <C>                       <C>
Common Stock, $0.01      3,063,568 (1)          $ 18.0625 (2)             $ 55,335,697 (2)          $ 19,081
par value (1991                          
Stock Option Plan)
- ------------------------------------------------------------------------------------------------------------------

</TABLE>

 

(1) This Registration Statement shall also cover any additional shares of
    Common Stock which become issuable under the Chiron 1991 Stock Option Plan,
    by reason of any stock dividend, stock split, recapitalization or other
    similar transaction effected without the receipt of consideration which
    results in an increase in the number of the Registrant's outstanding shares
    of Common Stock.
(2) Calculated solely for the purposes of this offering under Rule 457(h) of
    the Securities Act of 1933 on the basis of the average of the high and low
    selling prices per share of Common Stock of Chiron Corporation on August
    15, 1996, as reported by the NASDAQ National Market System.

This Registration Statement shall become effective immediately upon filing with
the Securities and Exchange Commission, and sales of the registered securities
will begin as soon as reasonably practicable after such effective date.

                                  ------------------

Also relates to Registration File Nos. 33-35182, 33-20181, 2-90595, 33-44477,
33-65024 and 33-65177 pursuant to Rule 429 under the Securities Act of 1933.

<PAGE>

                                       PART II

                  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

    The contents of the Registration Statement on Form S-8 (File No. 33-44477),
filed by Chiron Corporation (the "Registrant") with the Securities and Exchange
Commission on December 12, 1991, are hereby incorporated by reference herein.

ITEM 8.  EXHIBITS.

Exhibit Number  Exhibit
- --------------  -------

    4.01      Rights Agreement, dated as of August 25, 1994, between the
              Company and Continental Stock Transfer & Trust Company, which
              includes the Certificate of Designations for the Series A Junior
              Participating Preferred Stock as Exhibit A, the form of Right
              Certificate as Exhibit B and the Summary of Rights to Purchase
              Preferred Shares as Exhibit C, incorporated by reference to
              Exhibit 4.04 of the Registrant's current report on Form 8-K dated
              August 25, 1994.

    4.02      Amendment No. 1 to Rights Agreement dated as of November 20,
              1994, between Chiron Corporation and Continental Stock Transfer &
              Trust Company, incorporated by reference to Exhibit 4.05 of the
              Registrant's current report on Form 8-K, dated November 20, 1994.

    4.03      Amendment No. 2 to Rights Agreement, dated as of August 9, 1996,
              between Chiron Corporation and Continental Stock Transfer & Trust
              Company, incorporated by reference to Exhibit 4.09 of the
              Registrant's Form 10-Q report for the period ended June 30, 1996.

    5         Opinion of William G. Green.

    23.1      Consent of KPMG Peat Marwick LLP, Independent Auditors, relating
              to the 1995 and 1994 consolidated financial statements of Chiron
              Corporation and subsidiaries.

    23.2      Consent of Ernst & Young LLP, Independent Auditors, relating to
              the 1993 consolidated financial statements of Chiron Corporation
              and subsidiaries.

    23.3      Consent of William G. Green is contained in Exhibit 5.

    24        Power of Attorney.  Reference is made to pages II-2 and II-3 of
              this Registration Statement.

    99.1      Chiron 1991 Stock Option Plan.


                                         II-1

<PAGE>

                                      SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized in the City of Emeryville, State of California, on the 19th day of
August, 1996.


                                  CHIRON CORPORATION

                                  By /s/ Edward E. Penhoet
                                     ----------------------------------------
                                       Edward E. Penhoet
                                       President and Chief Executive Officer


                                  POWER OF ATTORNEY

    KNOW ALL PERSONS BY THESE PRESENTS, that the undersigned officers and
directors of Chiron Corporation, a Delaware corporation, do hereby constitute
and appoint Edward E. Penhoet and William J. Rutter, and each of them, the
lawful attorneys and agents or attorney and agent with full power and authority
to do any and all acts and things and to execute any and all instruments which
said attorneys and agents, and any one of them, determine may be necessary or
advisable or required to enable said corporation to comply with the Securities
Act of 1933, as amended, and any rules or regulations or requirements of the
Securities and Exchange Commission in connection with this Registration
Statement.  Without limiting the generality of the foregoing power and
authority, the powers granted include the power and authority to sign the names
of the undersigned officers and directors in the capacities indicated below this
Registration Statement, to any and all amendments, both pre-effective and post-
effective, and supplements to this Registration Statement, and to any and all
instruments or documents filed as part of or in conjunction with this
Registration Statement or amendments or supplements thereof, and each of the
undersigned hereby ratifies and confirms all that said attorneys and agents, or
any one of them shall do or cause to be done by virtue hereof.  This Power of
Attorney may be signed in several counterparts.

    IN WITNESS WHEREOF, each of the undersigned has executed this Power of
Attorney as of the date indicated.


                                         II-2

<PAGE>

    Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the date indicated.

SIGNATURE                              TITLE                         DATE

/s/ Edward E. Penhoet, Ph.D.    President, Chief Executive       August 19, 1996
- -----------------------------   Officer and Director
(Edward E. Penhoet, Ph.D.)      (Principal Executive Officer)


/s/ William J. Rutter, Ph.D.    Chairman of the Board            August 19, 1996
- -----------------------------
(William J. Rutter, Ph.D.)


/s/ Dennis L. Winger           Senior Vice President,            August 19, 1996
- -----------------------------  Finance and Administration,
(Dennis L. Winger)             Chief Financial Officer
                               (Principal Financial and
                               Accounting Officer)


/s/ Lewis W. Coleman           Director                          August 19, 1996
- -----------------------------
(Lewis W. Coleman)


/s/ Pierre E. Douaze            Director                         August 19, 1996
- -----------------------------
(Pierre E. Douaze)


/s/ Donald A. Glaser, Ph.D.     Director                         August 19, 1996
- -----------------------------
(Donald A. Glaser, Ph.D.)


                                Director       
- -----------------------------
(Alex Krauer, Ph.D.)


/s/ Henri Schramek, Ph.D.       Director                         August 19, 1996
- -----------------------------
(Henri Schramek, Ph.D.)


/s/ Jack W. Schuler             Director                         August 19, 1996
- -----------------------------
(Jack W. Schuler)


/s/ Pieter J. Strijkert, Ph.D.  Director                         August 19, 1996
- -----------------------------
(Pieter J. Strijkert, Ph.D.)


                                         II-3

<PAGE>

                          SECURITIES AND EXCHANGE COMMISSION
                               WASHINGTON, D.C.  20549


                                       EXHIBITS
                                          TO
                                       FORM S-8
                                        UNDER
                                SECURITIES ACT OF 1933

                                  CHIRON CORPORATION

<PAGE>

                                    EXHIBIT INDEX


Exhibit Number  Exhibit
- --------------  -------

    4.01      Rights Agreement, dated as of August 25, 1994, between the
              Company and Continental Stock Transfer & Trust Company, which
              includes the Certificate of Designations for the Series A Junior
              Participating Preferred Stock as Exhibit A, the form of Right
              Certificate as Exhibit B and the Summary of Rights to Purchase
              Preferred Shares as Exhibit C, incorporated by reference to
              Exhibit 4.04 of the Registrant's current report on Form 8-K dated
              August 25, 1994.

    4.02      Amendment No. 1 to Rights Agreement dated as of November 20,
              1994, between Chiron Corporation and Continental Stock Transfer &
              Trust Company, incorporated by reference to Exhibit 4.05 of the
              Registrant's current report on Form 8-K, dated November 20, 1994.

    4.03      Amendment No. 2 to Rights Agreement, dated as of August 9, 1996,
              between Chiron Corporation and Continental Stock Transfer & Trust
              Company, incorporated by reference to Exhibit 4.09 of the
              Registrant's Form 10-Q report for the period ended June 30, 1996.

    5         Opinion of William G. Green.

    23.1      Consent of KPMG Peat Marwick LLP, Independent Auditors, relating
              to the 1995 and 1994 consolidated financial statements of Chiron
              Corporation and subsidiaries.

    23.2      Consent of Ernst & Young LLP, Independent Auditors, relating to
              the 1993 consolidated financial statements of Chiron Corporation
              and subsidiaries.

    23.3      Consent of William G. Green is contained in Exhibit 5.

    24        Power of Attorney.  Reference is made to pages II-2 and II-3 of
              this Registration Statement.

    99.1      Chiron 1991 Stock Option Plan.

<PAGE>


                                      EXHIBIT 5

August 19, 1996

Chiron Corporation
4560 Horton Street
Emeryville, CA  94608

Re: Chiron Corporation
    Registration Statement for Offering of
    Shares of Common Stock

Ladies and Gentlemen:

In connection with your registration of 3,063,568 shares of the Common Stock of
Chiron Corporation (the "Company") on Form S-8 under the Securities Act of 1933,
as amended, I advise you that, in my opinion, when such shares have been issued
and sold pursuant to the provisions of the Chiron 1991 Stock Option Plan, and in
accordance with the Registration Statement, such shares will be duly authorized,
validly issued, fully paid and non-assessable shares of the Company's Common
Stock.

I hereby consent to filing of this opinion as an exhibit to the Registration
statement.

Very truly yours,

/s/ William G. Green

William G. Green
Senior Vice President and
General Counsel


<PAGE>

                                                                    EXHIBIT 23.1

                CONSENT OF KPMG PEAT MARWICK LLP, INDEPENDENT AUDITORS


We consent to incorporation herein by reference of our report dated February 20,
1996, relating to the consolidated balance sheets of Chiron Corporation and
subsidiaries as of December 31, 1995 and 1994 and the related consolidated
statements of operations, stockholders' equity and cash flows for the years then
ended and the related schedule, which report appears in the December 31, 1995
annual report on Form 10-K of Chiron Corporation.



                                                           KPMG PEAT MARWICK LLP


San Francisco, California
August 15, 1996

<PAGE>

                                                                    EXHIBIT 23.2


                  CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS



We consent to the incorporation by reference in the Registration Statement (Form
S-8) pertaining to the Chiron 1991 Stock Option Plan of our report dated
February 25, 1994, with respect to the consolidated statements of operations,
stockholders' equity and cash flows and schedule of Chiron Corporation for the
year ended December 31, 1993 included in its Annual Report (Form 10-K) for the
year ended December 31, 1995, filed with the Securities and Exchange Commission.


                                                               ERNST & YOUNG LLP

San Francisco, California
August 15, 1996

<PAGE>
                                                                   EXHIBIT 99.1

                         CHIRON 1991 STOCK OPTION PLAN
  [AS AMENDED AUGUST 14, 1993, APRIL 11, 1994, FEBRUARY 24, 1995 AND MARCH 8,
                                     1996]
 
I.  PURPOSES
 
    This  Chiron 1991  Stock Option Plan  ("Plan") is intended  to enable Chiron
Corporation ("Corporation") to attract and  retain the following individuals  by
offering them incentives and rewards, in the form of options, restricted shares,
share  rights, share units and performance units ("awards") which will encourage
them to acquire a  proprietary interest in the  Corporation, to continue in  the
service  of the  Corporation or  its subsidiaries,  and to  provide incentive to
build value for stockholders: (a)  employees (including officers and  directors)
of  the Corporation and its subsidiaries,  (b) non-employee members of the Board
of Directors of the Corporation  ("Board"), and (c) consultants and  independent
contractors   who  perform  valuable  services   for  the  Corporation  and  its
subsidiaries.
 
    In addition, the Plan is intended  to permit the Corporation to satisfy  its
obligations  in connection with options it will  assume pursuant to the terms of
the Agreement and  Plan of Merger  dated as of  July 21, 1991  by and among  the
Corporation,   Chiron  Acquisition  Subsidiary,   Inc.,  and  Cetus  Corporation
("Agreement"). Upon consummation of the transactions described in the  Agreement
("Merger"),  the Plan  will supersede  Cetus Corporation's  Amended and Restated
Common Stock Option Plan and  Cetus Corporation's Non-Employee Directors'  Stock
Option  Plan ("Cetus  Prior Plans"). Upon  stockholder approval,  this Plan will
also supersede the  following Chiron  prior plans: the  Protos Corporation  1988
Stock  Option  Plan  (upon  the  merger  of  Protos  into  Chiron),  the  Chiron
Ophthalmics, Inc. 1986 Stock Option Plan (upon the merger of Chiron  Ophthalmics
into  a wholly owned subsidiary of  Chiron), the Corporation's 1982 Stock Option
Plan and the Corporation's 1984  Non-Qualified Stock Option Plan  (collectively,
"Chiron Prior Plans").
 
II.  ADMINISTRATION
 
    The  Plan will be administered by a committee or committees appointed by the
Board and consisting of one or more members of the Board. The Board may delegate
the responsibility for  administration of  the Plan with  respect to  designated
classes of award holders to different committees, subject to such limitations as
the  Board deems appropriate. With respect  to any matter, the term "Committee,"
when used in  this Plan, will  refer to  the committee that  has been  delegated
authority  with respect to  such matter. Members  of a committee  will serve for
such term as  the Board may  determine, and will  be subject to  removal by  the
Board at any time.
 
    (a)   16(b)  The composition of any committee responsible for administration
of the  Plan with  respect  to award  holders who  are  subject to  the  trading
restrictions  of Section  16(b) of  the Securities  Exchange Act  of 1934 ("1934
Act") with  respect  to securities  of  the  Corporation will  comply  with  the
applicable requirements of Rule 16b-3 of the Securities and Exchange Commission.
 
    (b)   162(m)  The composition of any committee responsible for establishing,
administering, and certifying  performance goals  for awards  granted under  the
Plan  that are  intended to comply  with Internal Revenue  Code ("Code") Section
162(m) ("performance units")  will comply  with the  applicable requirements  of
Code Section 162(m) and the regulations promulgated thereunder.
 
    (c)    AUTHORITY.   Any  committee appointed  by  the Board  will  have full
authority  to  administer   the  Plan   within  the  scope   of  its   delegated
responsibilities,  including authority  to interpret  and construe  any relevant
provision of  the Plan,  to adopt  such rules  and regulations  as it  may  deem
necessary,  and to determine the  terms and conditions of  awards made under the
Plan (which need  not be identical).  Decisions of a  committee made within  the
discretion delegated to it by the Board will be final and binding on all persons
who have an interest in the Plan.
 
                                        1
<PAGE>
III.  ELIGIBILITY FOR AWARDS
 
    (a)   DISCRETIONARY  AWARDS.  From  time to  time the Committee  may, in its
discretion, select individuals  from among the  following categories to  receive
awards under the Plan:
 
        (1)   EMPLOYEES.  The Committee  may select employees of the Corporation
    or its  subsidiaries  (including officers,  whether  or not  they  are  also
    members of the Board).
 
        (2)   CONSULTANTS AND INDEPENDENT CONTRACTORS.  The Committee may select
    consultants and independent  contractors whose services  tend to  contribute
    materially  to the success  of the Corporation or  its subsidiaries or whose
    services may reasonably be anticipated to so contribute.
 
    (b)   PERFORMANCE  UNITS.   Corporate  vice-presidents and  other  executive
officers  ("162(m) executives") will be eligible to receive performance units in
addition to, or in lieu of, other discretionary awards granted under the Plan.
 
    (c)  AUTOMATIC GRANTS.   Members of the Board who  are not employees of  the
Corporation or its subsidiaries will receive awards in accordance with, and only
in accordance with, the Plan's automatic award provisions.
 
    (d)    SUBSTITUTE OPTIONS.   Upon  consummation  of the  Merger, outstanding
options  under  the   Cetus  Prior  Plans   (including  related  Limited   Stock
Appreciation  Rights) will be converted, in the manner and at the exchange ratio
specified in the Agreement, into substitute  options under this Plan to  acquire
Common  Stock (as defined below). Upon  stockholder approval and, with regard to
the Protos prior  plan options and  the Chiron Ophthalmics  prior plan  options,
consummation of the relevant mergers, outstanding options under the Chiron Prior
Plans  will  be  converted into  options  under  this Plan.  These  options will
preserve the exercise price of the outstanding options as adjusted, in the  case
of  options under the Protos  Corporation 1988 Stock Option  Plan and the Chiron
Ophthalmics, Inc. 1986 Stock Option Plan, to reflect the substitution of  Common
Stock.  These options will also  preserve the other terms  and conditions of the
outstanding options; provided, however, that on the Effective Date of this Plan,
outstanding automatic option  grants under the  Corporation's 1982 Stock  Option
Plan  will be conformed, other than to  extend the term, to the Automatic Option
Grants under this Plan. Collectively, these options will be known as "Substitute
Options."
 
IV.  STOCK SUBJECT TO THE PLAN
 
    (a)   CLASS.   The  stock  subject  to awards  under  the Plan  is  (i)  the
Corporation's  authorized  but  unissued  or  reacquired  Common  Stock ("Common
Stock"), or (ii) shares  of one or more  series of the Corporation's  authorized
but  unissued or reacquired Restricted Common  Stock, in the aggregate, "Company
Stock." In connection with the grant  of awards under the Plan, the  Corporation
may repurchase shares in the open market or otherwise.
 
    (b)  AGGREGATE AMOUNT
 
        (1)   SHARES.  Subject to  adjustment under Sections IV(c) and IV(b)(3),
    the aggregate maximum number of shares of Company Stock that may be  subject
    to  awards under the Plan is 4,500,000  plus the number of shares of Company
    Stock remaining for issuance  on the Effective Date  of this Plan under  the
    Corporation's   1982   Stock  Option   Plan   and  the   Corporation's  1984
    Non-Qualified Stock  Option  Plan.  Notwithstanding  the  foregoing,  as  of
    January  1 of each fiscal year after 1991, the aggregate number of shares of
    Company Stock that may be subject to awards under the Plan will be increased
    by 1.50% of the number of Chiron Common Equivalent Shares outstanding as  of
    December  31 of the preceding  fiscal year. The maximum  number of shares of
    Company Stock with respect  to which awards may  be granted to any  employee
    during the term of the Plan is 1,000,000 shares. Subject to adjustment under
    Sections IV(c) and IV(b)(3), not more than 4,500,000 shares of Company Stock
    plus  the number of  shares of Company  Stock remaining for  issuance on the
    Effective Date of this Plan under  the Corporation's 1982 Stock Option  Plan
    and the Corporation's 1984 Non-Qualified Stock Option Plan may be subject to
    Incentive  Options  (as  defined below)  granted  under the  Plan  after the
    Effective Date. "Chiron Common  Equivalent Shares" are  the total number  of
    outstanding shares of Common Stock plus the total
 
                                        2
<PAGE>
    number  of shares  of Common Stock  issuable upon conversion  or exercise of
    outstanding warrants, options and convertible  securities. In no event  will
    more  than 500,000  shares of Restricted  Common Stock, whether  in a single
    series or in multiple series, be subject to award under the Plan.
 
        (2)  RESTRICTED COMMON STOCK.  Shares of Restricted Common Stock may  be
    issued  under  the  Plan  in  one  or  more  separate  series.  The  rights,
    preferences and privileges, together  with the restrictions and  limitations
    and the number of shares, of each series of Restricted Common Stock issuable
    under  the  Plan  will be  set  forth  in the  Corporation's  Certificate of
    Determination of Preferences  of Common Stock  ("Certificate") as in  effect
    from  time to  time during the  term of the  Plan. Shares of  each series of
    Restricted Common Stock will be  convertible or exchangeable into shares  of
    Common  Stock in accordance with the terms and provisions of the Certificate
    applicable to that series.
 
        (3)  REUSE OF SHARES.  If any outstanding option under the Chiron  Prior
    Plans, the Cetus Prior Plans or this Plan (including the Substitute Options)
    expires  or is terminated or canceled  for any reason (including pursuant to
    Section X of the Plan but other than pursuant to surrender of the option for
    a cash payment  in accordance with  Section XIII of  the Plan) before  being
    exercised for the full number of shares to which it applies, then the shares
    allocable  to the  unexercised portion  of such  option will  not be charged
    against the limitations of  Section IV(b)(1) and  will become available  for
    subsequent  grants under the Plan. To the extent that a share right or share
    unit expires or is  terminated, or is canceled  or forfeited for any  reason
    without  being paid in cash or shares of Company Stock, any remaining shares
    allocable to the unpaid portion of such share right or share unit shall  not
    be  charged  against the  limitations of  Section  IV(b)(1) and  will become
    available again for subsequent grants under the Plan. Shares subject to  any
    option or portion of an option surrendered in accordance with the "Surrender
    of  Options for Cash or  Stock" provisions of this  Plan, shares for which a
    cash payment is made in lieu thereof under a restricted share, share unit or
    share right,  and shares  forfeited  to or  repurchased by  the  Corporation
    pursuant to its forfeiture and repurchase rights under this Plan will not be
    available for subsequent awards under the Plan.
 
    (c)   ADJUSTMENTS.   In the  event any change  is made to  the Company Stock
subject to the Plan (whether by reason of merger, consolidation, reorganization,
recapitalization, stock dividend, stock  split, combination of shares,  exchange
of shares, or other change in corporate or capital structure of the Corporation)
then, unless such change results in the termination of all awards, the Committee
will  make  appropriate adjustments  to the  kind and  maximum number  of shares
subject to the Plan, the kind and maximum number of shares for which options are
to be granted to non-employee directors, and the kind and number of shares  and,
where applicable, price per share of stock subject to outstanding awards.
 
V.  TERMS AND CONDITIONS OF OPTIONS
 
    Stock  options granted under the Plan may, in the Committee's discretion, be
either incentive stock  options ("Incentive Options")  qualifying under  Section
422  of the Internal Revenue Code of 1986, as amended ("Internal Revenue Code"),
or nonstatutory options. Individuals who are not employees of the Corporation or
its subsidiaries  may only  be  granted nonstatutory  options. Options  will  be
evidenced  by instruments in  such form as  the Committee may  from time to time
approve. These instruments will  conform to the  following terms and  conditions
and,  in  the  discretion  of  the  Committee,  may  contain  such  other terms,
conditions and restrictions as are not inconsistent with the following:
 
    (a)   OPTION PRICE.    The option  price  per share  will  be fixed  by  the
Committee,  but  in  no event  will  the option  price  per share  be  less than
eighty-five percent (85%) of the Fair Market  Value of the option shares on  the
date  of the option grant;  provided, however, that in  no event will the option
price per share of an Incentive Option  be less than one hundred percent  (100%)
of  the Fair Market Value of the option  shares on the date of the option grant.
Notwithstanding the foregoing, Substitute Options will have an option price  per
share determined pursuant to Section III(d) of this Plan.
 
                                        3
<PAGE>
    (b)  NUMBER OF SHARES, TERM AND EXERCISE
 
        (1)    TERM AND  NUMBER.   Each option  granted under  the Plan  will be
    exercisable on such date or dates,  during such period, and for such  number
    of shares of Company Stock as the Committee determines and sets forth in the
    instrument evidencing the option. No option granted under the Plan will have
    an  expiration date that is more than 10  years after the date of the option
    grant.
 
        (2)   EXERCISE.    After  any option  granted  under  the  Plan  becomes
    exercisable,  it may be exercised  by notice to the  Corporation at any time
    prior to  the  termination of  such  option.  Except as  authorized  by  the
    Committee  in accordance with Section VIII,  the option price for the number
    of shares for which the option is exercised will become due and payable upon
    exercise.
 
        (3)   PAYMENT.   The  option  price will  be  payable in  full  in  cash
    (including  cash equivalents);  provided, however,  that the  Committee may,
    either at the time the option is granted or at the time it is exercised  and
    subject to such limitations as it may determine, authorize payment of all or
    a  portion of  the option  price in  one or  a combination  of the following
    alternative forms:
 
            (i) a promissory note authorized pursuant to Section VIII;
 
           (ii) full payment in shares of Common Stock valued as of the exercise
       date and  held  for  the  requisite  period to  avoid  a  charge  to  the
       Corporation's earnings; or
 
          (iii) by delivery of a properly executed exercise notice together with
       irrevocable   instructions  to  a  broker  to  promptly  deliver  to  the
       Corporation the amount of sale or loan proceeds to pay the option price.
 
    (c)  TERMINATION OF SERVICES.  The Committee will determine and set forth in
each option whether the  option will continue to  be exercisable, and the  terms
and  conditions of such exercise, on and  after the date that an optionee ceases
to  be  employed  by,  or  to  provide  services  to,  the  Corporation  or  its
subsidiaries.  The date of  termination of an  optionee's employment or services
will be determined by the Committee, which determination will be final.
 
    (d)  INCENTIVE OPTIONS.  Options granted under the Plan that are intended to
be Incentive  Options will  be subject  to the  following additional  terms  and
conditions:
 
        (1)   DOLLAR LIMITATION.   To the extent that  the aggregate Fair Market
    Value (determined as  of the respective  date or dates  of grant) of  shares
    with  respect to which  options that are  granted after 1986  and that would
    otherwise be Incentive  Options are exercisable  for the first  time by  any
    individual during any calendar year under the Plan (or any other plan of the
    Corporation,  a  parent or  subsidiary  corporation or  predecessor thereof)
    exceeds the sum  of $100,000  (or such greater  amount as  may be  permitted
    under  the  Internal Revenue  Code), whether  by  reason of  acceleration or
    otherwise, such options will not be treated as Incentive Options. In  making
    such  a determination, options  will be taken  into account in  the order in
    which they  were  granted.  The  aggregate Fair  Market  Value  (as  of  the
    respective  date or dates of grant) of  shares of the Corporation (or parent
    or subsidiary corporation) for which  Incentive Options could be granted  to
    any  one individual in a  single calendar year before  1987 could not exceed
    $100,000 at the time of grant,  plus unused carryovers from the  immediately
    preceding three calendar years.
 
        (2)  10% STOCKHOLDER.  If any employee to whom an Incentive Option is to
    be  granted pursuant to the provisions of the Plan is, on the date of grant,
    the owner of stock (determined with application of the ownership attribution
    rules of Section 424(d) of the  Internal Revenue Code) possessing more  than
    ten percent (10%) of the total combined voting power of all classes of stock
    of  his  or  her  employer  corporation  or  of  its  parent  or  subsidiary
    corporation ("10% Stockholder"), then the following special provisions  will
    apply to the option granted to such individual:
 
           (i) The option price per share of the stock subject to such Incentive
       Option  will not be less than one  hundred ten percent (110%) of the Fair
       Market Value of the option shares on the date of grant; and
 
                                        4
<PAGE>
           (ii) The option will not have a term in excess of five (5) years from
       the date of grant.
 
        (3)  SEQUENTIAL EXERCISE.  No Incentive Option granted before January 1,
    1987 may be exercised  while there remains  outstanding any other  Incentive
    Option  to purchase shares  of the Corporation (or  its parent or subsidiary
    corporation) which was granted at an earlier date to the optionee.
 
        (4)  PARENT AND SUBSIDIARY.   For purposes of this Section V(d)  "parent
    corporation"  and "subsidiary corporation" will  have the meaning attributed
    to those terms, as they are used  in Section 422(b) of the Internal  Revenue
    Code.
 
    (e)  WITHHOLDING
 
        (1)    OBLIGATION.    The  Corporation's  obligation  to  deliver  stock
    certificates upon the exercise  of an option will  be subject to the  option
    holder's  satisfaction of all applicable federal, state and local income and
    employment tax withholding requirements.
 
        (2)  PAYMENT.  In the event that an option holder is required to pay  to
    the  Corporation  an  amount  with  respect  to  income  and  employment tax
    withholding obligations  in  connection  with exercise  of  an  option,  the
    Committee  may, in its discretion and  subject to such limitations and rules
    as it may  adopt, permit  the option holder  to satisfy  the obligation,  in
    whole  or in part, by delivering shares  of Common Stock already held by the
    option holder or  by making an  irrevocable election that  a portion of  the
    total  value of the shares subject to the option be paid in the form of cash
    in lieu of  the issuance of  Company Stock,  and that such  cash payment  be
    applied to the satisfaction of the withholding obligations.
 
VI.  RESTRICTED SHARES, SHARE RIGHTS AND SHARE UNITS
 
    (a)  NATURE OF AWARDS
 
        (1)  RESTRICTED SHARES.  A restricted share granted under the Plan shall
    consist  of shares of Company Stock, the  retention and transfer of which is
    subject to  such  terms,  conditions  and  restrictions  (whether  based  on
    performance  standards  or periods  of  service or  otherwise  and including
    repurchase and/or  forfeiture rights  in favor  of the  Corporation) as  the
    Committee  shall determine. The terms,  conditions and restrictions to which
    restricted shares are subject shall be evidenced by instruments in such form
    as the Committee may from  time to time approve and  may vary from grant  to
    grant. The Committee shall have the absolute discretion to determine whether
    any consideration (other than the services of the potential award holder) is
    to  be  received  by the  Corporation  or  its subsidiaries  as  a condition
    precedent to the issuance of restricted shares.
 
        (2)  SHARE RIGHTS.  A share  right granted under the Plan shall  consist
    of  the right, subject  to such terms,  conditions and restrictions (whether
    based on  performance standards  or  periods of  service or  otherwise),  to
    receive a share of Company Stock (together with cash dividend equivalents if
    so  determined by the Committee) as  the Committee shall determine and shall
    be evidenced by instruments in such form  as the Committee may from time  to
    time  approve. The Committee shall have the absolute discretion to determine
    whether any consideration (other  than the services  of the potential  award
    holder)  is  to be  received by  the  Corporation or  its subsidiaries  as a
    condition precedent to the issuance of shares pursuant to share rights.  The
    terms,  conditions and  restrictions to which  share rights  are subject may
    vary from grant to grant.
 
        (3)  SHARE UNITS.  A share unit granted under the Plan shall consist  of
    the right to receive an amount in cash equal to the Fair Market Value of one
    share  of Company Stock on the date  of valuation of the unit (together with
    cash dividend  equivalents if  so  determined by  the Committee)  less  such
    amount,  if any, as the  Committee shall specify. The  date of valuation and
    payment of cash under a share unit and the conditions, if any, to which such
    payment will be subject (whether  based on performance standards or  periods
    of  service or otherwise)  shall be determined by  the Committee. The terms,
    conditions and restrictions to which share  units are subject may vary  from
    grant to grant.
 
    (b)   WITHHOLDING.  The Committee may  require, or permit an award holder to
elect, that a portion of the total  value of the shares of Common Stock  subject
to  restricted shares or share rights held by  one or more award holders be paid
in the form of cash in lieu of the issuance of Company Stock and that such  cash
 
                                        5
<PAGE>
payment  be applied to the  satisfaction of the federal,  state and local income
and employment tax withholding obligations that arise at the time the restricted
shares and share rights become free of all restrictions under the Plan.
 
    (c)   CASH  PAYMENTS.   The  Committee may  provide  award holders  with  an
election to receive a percentage of the total value of the Company Stock subject
to  restricted shares or share rights in the  form of a cash payment, subject to
such terms, conditions and restrictions as the Committee shall specify.
 
    (d)  ELECTIVE AND TANDEM AWARDS.  The Committee may award restricted shares,
share rights and share units independently  of other compensation or in lieu  of
compensation  that would otherwise be paid in  cash or stock options, whether at
the election  of  the  potential  award  holder  or  otherwise.  The  number  of
restricted shares, share rights or share units to be awarded in lieu of any cash
compensation  amount  or number  of  stock options  shall  be determined  by the
Committee in  its  sole  discretion and  need  not  be equal  to  such  foregone
compensation  in Fair Market Value. In addition, restricted shares, share rights
and share units may be awarded in  tandem with stock options, so that a  portion
of such award becomes payable or becomes free of restrictions only if and to the
extent  that the tandem options  are not exercised or  are forfeited, subject to
such terms and conditions as the Committee may specify.
 
    (e)  MODIFICATION OF AWARDS.  Except to the extent an award is granted as  a
performance unit, the Committee may, in its sole discretion, modify or waive any
or  all of the  terms, conditions or restrictions  applicable to any outstanding
restricted share, share  right or share  unit; provided, however,  that no  such
modification  or  waiver  shall,  without  the  consent  of  the  holder  of  an
outstanding award, adversely affect the holder's rights thereunder.
 
    (f)  PERFORMANCE UNITS.   Effective March 8,  1996, the Committee may  grant
restricted shares, share rights and share units to 162(m) executives that comply
with  the requirements  of Code  Section 162(m).  Performance units  will become
payable or vest upon attainment of specified performance goals over a  specified
performance period.
 
        (1)   PERFORMANCE GOALS.   The Committee  will determine the Corporation
    performance goal or  goals that must  be met to  achieve the maximum  payout
    within  the shorter of the first 90 days of the specified performance period
    over which the performance goal  or goals will be  measured, or 25% of  such
    performance  period. The Committee  may establish a goal  based on more than
    one performance criteria, or  may establish multiple  goals, but any  payout
    must  be based on the  satisfaction of at least  one goal. The Committee may
    provide for different levels of payouts based on relative performance toward
    a performance goal.
 
        (2)  PERFORMANCE  CRITERIA.  Performance  units may be  based on one  or
    more  of the following  performance criteria: total  shareholder return; the
    achievement of a specified closing or average closing price of Common Stock;
    the absolute or percentage increase in the closing or average closing  price
    of  Common  Stock  and/or one  or  more  of the  following  measures  of the
    Corporation's net income for the specified performance period determined  in
    accordance  with  generally accepted  accounting principles  as consistently
    applied by the Corporation: absolute net income or a percentage or  absolute
    dollar  increase  in  net income,  earnings  per  share or  a  percentage or
    absolute dollar increase in earnings per share, or return on assets employed
    or equity, or a percentage or  absolute dollar increase in return on  assets
    employed  or  equity;  or the  Corporation's  absolute gross  revenues  or a
    percentage or absolute dollar increase  in gross revenues for the  specified
    performance   period  determined  in   accordance  with  generally  accepted
    accounting principles as consistently applied by the Corporation. The awards
    may be based on  the Corporation's performance  alone, or the  Corporation's
    performance  may be measured against  variously weighted published benchmark
    indices  that   the  Committee   determines   are  representative   of   the
    Corporation's  peer group, which  indices may include  the Standard & Poor's
    Health Care Composite Index, the  Standard & Poor's Health Care  Diversified
    Index and the AMEX Biotechnology Index, among others.
 
    For purposes of this Plan, net income and gross revenues shall be net income
    and  gross revenues of the Corporation  and its consolidated subsidiaries as
    reported by the Corporation and certified by its
 
                                        6
<PAGE>
    independent public accountants,  but the  Committee in fixing  any goal  may
    exclude any or all of the following if they have a material effect on annual
    net income or gross revenues: events or transactions that are either unusual
    in  nature or infrequent in occurrence (such as restructuring/reorganization
    charges, the  purchase  or  sale  of in  process  technology,  the  sale  or
    discontinuance  of a  business segment,  the sale  of investment securities,
    losses from  litigation,  the cumulative  effect  of changes  in  accounting
    principles, and natural disasters), depreciation, interest or taxes.
 
        (3)   REDUCTION OR CANCELLATION OF PERFORMANCE UNITS.  Final payouts are
    subject to the approval of the Committee, and the Committee has the absolute
    discretion to reduce or cancel any payout.
 
VII.  AUTOMATIC AWARDS TO DIRECTORS
 
    (a)  OPTIONS.   Effective March 8, 1996,  non-employee members of the  Board
("Eligible  Directors")  will  automatically  be  granted  nonstatutory  options
("Automatic  Options")  to  purchase  the  number  of  shares  of  Common  Stock
determined as set forth below (subject to adjustment under Section IV(c) hereof)
on the dates and terms set forth below:
 
        (1)   OPTION GRANTS.  On the last  business day of the second quarter of
    each  fiscal  year  of  the  Corporation  ("Automatic  Grant  Date"),   each
    continuing  Eligible Director (including each Eligible Director who is newly
    elected or appointed on the Automatic Grant Date) will receive an  Automatic
    Option to purchase that number of whole shares of Common Stock determined by
    dividing $100,000 by the Average Stock Price on the Automatic Grant Date.
 
        (2)    PRO RATA  OPTION GRANTS.   Each  person who  is newly  elected or
    appointed as an Eligible  Director on a date  other than an Automatic  Grant
    Date,  will  receive,  on  the  date of  such  election  or  appointment, an
    Automatic Option to  purchase a pro  rata number of  whole shares of  Common
    Stock  determined by multiplying  $8,333.33 by the  number of whole calendar
    months between the date of  the Eligible Director's election or  appointment
    and  the next Automatic Grant Date, and  dividing that number by the Average
    Stock Price on the grant date.
 
        (3)   ADVISORY COUNSELLORS.    Advisory Counsellors  of Cetus  will  not
    qualify for Automatic Options.
 
        (4)   TERMS AND CONDITIONS.  The terms and conditions applicable to each
    Automatic Option will be as follows:
 
            (i)  PRICE.  The option price per share will be equal to one hundred
       percent (100%) of the Fair Market Value  of one share of Common Stock  on
       the date of grant.
 
            (ii)   TERM.   Each Automatic  Option will  have a term  of ten (10)
       years, measured from the  date of grant, and  will be exercisable at  any
       time during the term for all or any part of the covered shares; provided,
       however,  that no Automatic Options may be exercised prior to approval of
       the Plan by the Corporation's stockholders.
 
           (iii)  REPURCHASE.  The shares purchased under the Automatic  Options
       will be subject to repurchase by the Corporation at the original exercise
       price  in  the  event  an  optionee ceases  to  provide  services  to the
       Corporation or its subsidiaries as a director, an employee, a  consultant
       or  an independent  contractor. The Corporation's  repurchase rights will
       lapse, and the optionee's interest in the purchased shares will vest,  in
       a  series of equal annual installments over the five-year period measured
       from the  grant date,  provided the  optionee continues  to provide  such
       services.  In addition, the Corporation's  repurchase right will lapse in
       its entirety, and the Automatic  Options will become fully vested  should
       one or more of the following events occur while the optionee is providing
       such  services: (A) the optionee's death, or (B) the optionee's permanent
       disability.
 
            (iv)  PAYMENT.   Upon exercise of the  Automatic Option, the  option
       price for the purchased shares will become payable immediately in cash or
       in shares of Common Stock that the optionee has held for at least six (6)
       months.  Payment  may also  be made  by delivery  of a  properly executed
       exercise notice together  with irrevocable  instructions to  a broker  to
       promptly  deliver to the  Corporation the amount of  sale proceeds to pay
       the option price.
 
                                        7
<PAGE>
            (v)   CESSATION.   In  the  event  the optionee  ceases  to  provide
       services  to  the  Corporation  or its  subsidiaries  as  a  director, an
       employee, a consultant or an independent contractor, the Automatic Option
       may be exercised, within the term  of the Automatic Option, for a  period
       of  three (3) months after the date of such cessation (twelve (12) months
       in the case of cessation by reason  of disability or death). In the  case
       of death, the Automatic Option may be exercised within such period by the
       estate or heirs of the optionee.
 
    (b)    SHARE  RIGHTS.   Effective  March  8, 1996,  Eligible  Directors will
automatically be granted share rights ("Automatic Share Rights") to receive  the
number  of shares  of Common  Stock determined  as set  forth below  (subject to
adjustment under Section IV(c) hereof) on the dates and terms set forth below:
 
        (1)  NEW DIRECTORS.  Each  newly elected or appointed Eligible  Director
    will  be granted, on the date of  such election or appointment, an Automatic
    Share Right to purchase that number  of whole shares determined by  dividing
    $40,000 by the Average Stock Price on the grant date.
 
        (2)  CONTINUING DIRECTORS.
 
            (i)   FULL GRANTS.     Subject to Subsection VII(b)(2)(ii) below, on
       each Automatic Grant  Date each incumbent,  continuing Eligible  Director
       will  be granted an Automatic Share Right to receive that number of whole
       shares of  Common Stock  determined by  dividing $25,000  by the  Average
       Stock  Price on the Automatic  Grant Date. Notwithstanding the foregoing,
       on the  Automatic Grant  Date  occurring in  June 1996,  each  continuing
       Eligible  Director elected  or appointed  before March  8, 1996,  will be
       granted an Automatic Share Right to  receive that number of whole  shares
       determined by using the $40,000 in lieu of the $25,000 figure.
 
           (ii)  PRO RATA GRANTS.    If an Eligible Director is newly elected or
       appointed  on  a  date  other  than  an  Automatic  Grant  Date,  on  the
       immediately succeeding Automatic Grant Date, such Eligible Director  will
       be  granted a  pro rata  Automatic Share Right  to receive  the number of
       whole shares  of Common  Stock determined  by multiplying  the number  of
       whole   calendar  months  since  the   Eligible  Director's  election  or
       appointment by $2,083.33 and  dividing the product  by the Average  Stock
       Price on the Automatic Grant Date.
 
        (3)    ADVISORY COUNSELLORS.   Advisory  Counsellors  of Cetus  will not
    qualify for Automatic Share Rights.
 
        (4)  TERMS AND CONDITIONS.  The terms and conditions applicable to  each
    Automatic Share Right will be as follows:
 
            (i)   TERM.  Each Automatic Share Right will have a term of five (5)
       years, measured from the grant date.
 
            (ii)  VESTING.  The Automatic Share  Right will vest in a series  of
       equal  annual installments  over the  five-year period  measured from the
       grant date, provided the Eligible Director continues to provide  services
       to  the Corporation  or its  subsidiaries as  a director,  an employee, a
       consultant or an independent contractor.  Shares of Common Stock will  be
       issued  in satisfaction  of the  Automatic Share  Right as  the Automatic
       Share Right vests.  In addition, full  vesting will occur  should one  or
       more  of  the  following  events occur  while  the  Eligible  Director is
       providing such services: (A)  the Eligible Director's  death, or (B)  the
       Eligible Director's permanent disability.
 
           (iii)    CESSATION.   In the  event the  Eligible Director  ceases to
       provide services to the Corporation or its subsidiaries as a director, an
       employee, a consultant or an independent contractor, the Automatic  Share
       Right shall terminate with respect to the unvested portion of the Award.
 
    (c)   COST-OF-LIVING INCREASES.  Each dollar  value used in this Article VII
will be subject to annual cost-of-living increases. The increases will be  based
on  the Consumer  Price Index, and  will occur automatically  beginning with the
1997 Automatic Grant Date.
 
                                        8
<PAGE>
    (d)  AVERAGE  STOCK PRICE.   Average Stock Price  means the average  closing
price  of one share  of Common Stock  as reported on  the Nasdaq National Market
System for the previous twelve month period ending on the last day of the  month
before the grant date of the award.
 
VIII.  LOANS AND INSTALLMENT PAYMENTS
 
    In  order to assist an award holder (including an employee who is an officer
or director of the  Corporation) in the acquisition  of shares of Company  Stock
pursuant  to  an  award granted  under  the  Plan (other  than  pursuant  to the
Automatic Award provisions of this Plan), the Committee may authorize, at either
the time of  the grant of  an award or  the time of  the acquisition of  Company
Stock  pursuant to the award (i) the extension  of a loan to the award holder by
the Corporation, (ii) the payment by the award holder of the purchase price,  if
any,  of  the Company  Stock  in installments,  or  (iii) the  guarantee  by the
Corporation of a loan obtained by the award holder from a third party. The terms
of any loans, guarantees  or installment payments,  including the interest  rate
and  terms of  repayment, will  be subject to  the discretion  of the Committee.
Loans, installment payments and guarantees may be granted without security,  the
maximum  credit available being the purchase price, if any, of the Company Stock
acquired plus the maximum federal and state income and employment tax  liability
that may be incurred in connection with the acquisition.
 
IX.  ASSIGNABILITY
 
    No  award granted under the Plan is  assignable or transferable by the award
holder other than by Will or by the laws of descent and distribution, and during
the lifetime of the award holder, only the award holder may exercise options  or
exercise the rights provided under awards granted under the Plan.
 
X.  CANCELLATION AND NEW GRANT OF OPTIONS
 
    The  Committee will have the authority to  effect, at any time and from time
to time, with the  consent of the affected  option holders, the cancellation  of
any  or all outstanding options  under the Plan, a Cetus  Prior Plan or a Chiron
Prior Plan (other than options  granted under automatic option grant  provisions
of these plans) and to grant in substitution therefor new options under the Plan
covering the same or different numbers of shares, but having an option price per
share  not less than eighty-five  percent (85%) of the  Fair Market Value on the
new grant date  or, in  the case  of an  Incentive Option,  one hundred  percent
(100%)  of the Fair Market  Value on the new  grant date (or, in  the case of an
Incentive Option granted to a 10% Stockholder, one hundred ten percent (110%) of
such Fair Market Value). If one or more of the cancelled options is an Incentive
Option granted before 1987 under a Cetus Prior Plan or a Chiron Prior Plan, then
such option  will,  solely  for  purposes  of  the  "sequential  exercise"  rule
applicable  to outstanding Incentive Options  granted before 1987, be considered
to be outstanding until the expiration  date initially specified for the  option
term of such option.
 
XI.  ACCELERATION AND TERMINATION OF AWARDS
 
    (a)   ACCELERATION.   In  the event  of an  agreement to  dispose of  all or
substantially all of the assets or outstanding capital stock of the  Corporation
by  means of a sale, merger, reorganization,  or liquidation, each award will be
automatically accelerated  so that  (1) options  become fully  exercisable  with
respect  to the total number of  shares purchasable under the options; provided,
however, that the  exercise of  accelerated Incentive Options  granted prior  to
1987  will remain  subject to  any limitations  imposed by  the Internal Revenue
Code's sequential exercise rule, (2)  restrictions on restricted shares will  be
eliminated, and the shares will immediately vest, and (3) share rights and share
units  will immediately vest and become  payable. The Committee may also provide
for the automatic termination of repurchase  rights upon the occurrence of  such
an event.
 
    (b)   NO ACCELERATION.  No acceleration of awards will occur if the terms of
the agreement require as  a prerequisite to the  consummation of any such  sale,
merger,  reorganization  or  liquidation that  each  such award  will  be either
assumed by the  successor corporation or  parent thereof or  be replaced with  a
comparable  award  subject  to shares  of  the successor  corporation  or parent
thereof. The determination of such comparability will be made by the  Committee,
and    its   determination    will   be    final,   binding    and   conclusive.
 
                                        9
<PAGE>
Upon  consummation   of  the   sale,  merger,   reorganization  or   liquidation
contemplated  by the  agreement, all  awards, whether  or not  accelerated, will
terminate unless  assumed  pursuant to  a  written agreement  by  the  successor
corporation or parent thereof.
 
    (c)   CORPORATE STRUCTURE.   The grant of awards under  this Plan will in no
way affect the right  of the Corporation to  adjust, reclassify, reorganize,  or
otherwise  change its  capital or business  structure or  to merge, consolidate,
dissolve, liquidate or  sell or  transfer all  or any  part of  its business  or
assets.
 
XII.  VALUATION
 
    With  regard to all Substitute Options, Fair Market Value will be determined
in accordance  with the  relevant option  plan documents  on the  date that  the
outstanding options were granted. With regard to awards granted under this Plan,
for  all valuation purposes under the Plan, the  Fair Market Value of a share of
Common Stock or Restricted  Common Stock (as  the case may  be) on any  relevant
date will be determined in accordance with the following provisions:
 
    (a) If the Common Stock or Restricted Common Stock is not at the time listed
or   admitted  to  trading  on  any  stock   exchange,  but  is  traded  in  the
over-the-counter market, the Fair Market Value  will be the average between  the
reported  high price and the reported low price  of one share of Common Stock or
Restricted Common Stock  (as the case  may be) on  the date in  question in  the
over-the-counter market, as such prices are reported by the National Association
of Securities Dealers through its NASDAQ system or any successor system.
 
    (b)  If the Common Stock or Restricted Common Stock is at the time listed or
admitted to trading on any  stock exchange, then the  Fair Market Value will  be
the  average between the reported  high price and the  reported low price of one
share of Common Stock  or Restricted Common  Stock (as the case  may be) on  the
date in question on the stock exchange that is the primary market for the stock,
as such prices are officially quoted on such exchange.
 
    (c)  If the Common Stock or Restricted Common  Stock (as the case may be) is
at the time neither  listed nor admitted  to trading on  any stock exchange  nor
traded  in  the over-the-counter  market, or  if  the Committee  determines that
neither subparagraph (a) nor subparagraph  (b) above reflects Fair Market  Value
of  the stock  and the award  was not  granted pursuant to  the Plan's Automatic
Award provisions, then the Fair Market Value will be determined by the Committee
after taking into account such factors as the Committee deems appropriate, or in
the case of Automatic Awards, by an independent third party valuation.
 
XIII.  SURRENDER OF OPTIONS FOR CASH OR STOCK
 
    (a)  STOCK  APPRECIATION RIGHTS.   If,  and only  if the  Committee, in  its
discretion,  elects to implement an option surrender program under the Plan, one
or more option holders may, upon such terms and conditions as the Committee  may
establish  at the time of the option grant or at any time thereafter, be granted
the right to surrender all  or part of an unexercised  option in exchange for  a
distribution equal in amount to the difference between (i) the Fair Market Value
(at date of surrender) of the shares for which the surrendered option or portion
thereof  is at the time exercisable and  (ii) the aggregate option price payable
for such shares.  The distribution to  which an option  holder becomes  entitled
under  this Section may be  made in shares of  Common Stock or Restricted Common
Stock, valued at Fair Market Value at the date of surrender, in cash, or  partly
in  shares and partly in  cash, as the Committee,  in its sole discretion, deems
appropriate. The option surrender provisions of  this Section will not apply  to
options granted pursuant to the Automatic Option Grant provisions of this Plan.
 
    (b)  LIMITED STOCK APPRECIATION RIGHTS.  If outstanding options of Cetus for
which  Substitute Options  are issued  pursuant to  Section III(d)  have Limited
Stock Appreciation Rights ("LSARs") attached thereto, then each such LSAR  shall
be  honored  by  the  Corporation  in  accordance  with  its  terms  and  remain
exercisable for a  period of  60 days following  the date  that stockholders  of
Cetus  approve the  Merger; provided, however,  that if the  LSAR was originally
granted within 6 months of the date that Cetus stockholders approve the  Merger,
then  the LSAR will be exercisable for  a period of 60 days following expiration
of such six-month period. Upon expiration of the applicable 60-day period,  each
such LSAR not
 
                                        10
<PAGE>
previously  exercised shall expire. Upon exercise of an LSAR, the related option
will be cancelled, and Chiron will pay to the LSAR holder an amount in cash  for
each  share with respect to which the LSAR is exercised determined in accordance
with the terms of the Cetus Prior Plans.
 
XIV.  REPURCHASE RIGHTS
 
    The Committee may, in  its discretion, establish  as a term  of one or  more
awards  granted under the Plan  that the Corporation (or  its assigns) will have
the right, exercisable upon the  award holder's termination of employment  with,
or  cessation  of  services  for,  the  Corporation  and  its  subsidiaries,  to
repurchase at the original price  paid, if any, for  such shares of (1)  Company
Stock  acquired by the award holder pursuant to the granted award, or (2) Common
Stock into which acquired Restricted Common Stock may have been converted or for
which Restricted Common Stock may have been exchanged. Any such repurchase right
will be exercisable  by the  Corporation (or its  assigns) upon  such terms  and
conditions (including provisions for the expiration of such right in one or more
installments)  as the  Committee may specify  in the  instrument evidencing such
right. The Committee will also have full power and authority to provide for  the
automatic  termination of  the Corporation's repurchase  rights, in  whole or in
part, thereby accelerating  the vesting of  any or all  of the purchased  shares
(other than purchased shares obtained pursuant to the Automatic Award provisions
of  this Plan) upon the occurrence of any change in control specified in Article
XI.
 
XV.  RIGHT OF FIRST REFUSAL
 
    The Committee may, in  its discretion, establish  as a term  of one or  more
awards  granted under the Plan that the Corporation has a right of first refusal
with respect to the proposed disposition  by the award holder (or any  successor
in interest by reason of purchase, gift or other mode of transfer) of any shares
of (1) Company Stock acquired by the award holder pursuant to the granted award,
or  (2) Common Stock into which purchased  Restricted Common Stock may have been
converted or for which acquired Restricted Common Stock may have been exchanged.
Any such right of first  refusal will be exercisable  by the Corporation or  its
assigns  in accordance with the terms and conditions specified in the instrument
evidencing such right.
 
XVI.  EFFECTIVE DATE AND TERM OF PLAN
 
    (a)  EFFECTIVE DATE.   The Plan became effective  on December 10, 1991,  the
date  it was approved by the Corporation's  stockholders. The Plan as amended is
effective March 8, 1996, subject to approval by the Corporation's  stockholders.
Any  awards granted under  the amended provisions  of the Plan  adopted March 8,
1996 will be granted subject to  approval by the Corporation's stockholders.  If
such  stockholder approval of the  amendments is not obtained  by March 7, 1997,
then the Plan will continue in accordance with the Plan provisions in effect  on
March 7, 1996.
 
    (b)   TERM.  Incentive Options may be granted under the Plan only within ten
years of  the  Effective Date  of  the Plan.  Subject  to this  limitation,  the
Committee  may grant awards under the Plan  at any time after the Effective Date
of the Plan and before the Plan is terminated by the Board.
 
XVII.  AMENDMENT OR DISCONTINUANCE
 
    (a)  BOARD.  The Board may  amend, suspend or discontinue the Plan in  whole
or  in  part at  any  time; provided,  however, that  (a)  except to  the extent
necessary to qualify as Incentive Options  any or all options granted under  the
Plan  that are intended to so qualify,  such action may not, without the consent
of the award  holder, adversely affect  rights and obligations  with respect  to
awards outstanding under the Plan; (b) the provisions of the Plan concerning the
eligibility  of non-employee  members of  the Board  for awards  and the amount,
price and timing of Automatic Option Grants  under this Plan may not be  amended
more  than once  every six  months, other  than to  comport with  changes in the
Internal Revenue Code or  rules thereunder; and (c)  the Board may not,  without
the  approval  of the  Corporation's  stockholders (1)  materially  increase the
number of  shares of  Company Stock  subject to  awards under  the Plan  (unless
necessary   to  effect  the  adjustments  required  under  Section  IV(c)),  (2)
materially modify the eligibility requirements for awards under the Plan, or (3)
make  any  other  change  with  respect  to  which  the  Board  determines  that
stockholder approval is required by applicable law or regulatory standards.
 
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<PAGE>
    (b)   COMMITTEE.  The Committee will have full power and authority to modify
or waive any or all of the  terms, conditions or restrictions applicable to  any
outstanding  award  (other  than Automatic  Option  Grants), to  the  extent not
inconsistent with the Plan.
 
    (c)  SUBSTITUTE OPTIONS.  Substitute Options will be subject to amendment in
accordance with the terms of this Plan.
 
XVIII.  NO OBLIGATION
 
    Nothing contained in the Plan  (or in any award  granted under this Plan,  a
Chiron  Prior  Plan or  a  Cetus Prior  Plan)  shall confer  upon  any employee,
consultant, or independent contractor any right to continue in the employ of, or
to provide  services  to, the  Corporation  or  any affiliate  or  constitute  a
contract  or  agreement  of employment  or  for  the provision  of  services, or
interfere in any way with the right of the Corporation or an affiliate to reduce
such employee's, consultant's or independent contractor's compensation from  the
rate  in existence at the time of the  granting of an award or to terminate such
employee's, consultant's or independent  contractor's employment or services  at
any  time, with or  without cause; but nothing  contained in the  Plan or in any
award granted under this Plan shall affect any contractual rights of an employee
pursuant to a written employment agreement.
 
XIX.  USE OF PROCEEDS
 
    The cash proceeds  received by  the Corporation pursuant  to awards  granted
under the Plan will be used for general corporate purposes.
 
XX.  COMPLIANCE
 
    (a)    FEDERAL  AND  STATE  LAWS.   No  option  may  be  exercised,  and the
Corporation will not be obligated to issue stock under any award unless, in  the
opinion  of  counsel  for the  Corporation,  such  exercise and  issuance  is in
compliance with all applicable federal and state securities laws. As a condition
to the grant  of any award,  or to the  issuance of stock  under any award,  the
Committee may require that the award holder agree to comply with such provisions
of  federal and state securities laws as may  be applicable to such grant, or to
the sale of  stock acquired  pursuant to  the Plan,  and that  the award  holder
deliver   to  the  Corporation  a  written  agreement,  in  form  and  substance
satisfactory to the Corporation and its counsel, implementing such agreement.
 
    (b)   INFORMATION.   The  Corporation  will  furnish to  each  award  holder
participating  in the Plan (other  than a key employee or  a director) a copy of
the Corporation's Annual Report to Stockholders for the most recent fiscal year,
and additional copies will be furnished,  without charge, to such award  holders
upon request to the Secretary of the Corporation.
 
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<PAGE>
                                   APPENDIX A
           SPECIAL PROVISIONS RELATED TO 1995 CIBA-GEIGY TRANSACTION
 
    Those  persons holding options  to acquire shares of  Common Stock under the
Corporation's 1991  Stock Option  Plan  on November  20,  1994 are  granted  the
following rights ("Rights") with respect to each such option:
 
    (i)  the right to receive upon the  closing of the tender offer contemplated
under the Investment Agreement entered into  on such date among the  Corporation
and  Ciba-Geigy Limited,  Ciba-Geigy Corporation  and Ciba  Biotech Partnership,
Inc. (the "Closing") a cash payment equal to (A) 37.33% of the number of  shares
of  Common  Stock with  respect to  which  each such  option would  first become
exercisable in calendar year 1995 multiplied by (B) the difference between  $117
per  share and the exercise price per share  of such option with respect to such
shares and
 
    (ii) with respect to  the remaining shares of  Common Stock subject to  each
such  option, the right, exercisable at any  time after the later of the Closing
or the date that such an option  first becomes exercisable with respect to  such
shares,  to surrender  that portion  of such option  relating to  37.33% of such
shares in return for a cash payment equal to (A) the difference between $117 per
share and the  exercise price per  share of  such option multiplied  by (B)  the
number  of shares with respect to which  such option is so surrendered. However,
the grant and exercise of any such right with respect to any officer or director
subject to Section 16 of the Securities Exchange Act of 1934 shall be subject to
stockholder approval  of the  grant of  such rights  at the  Corporation's  1995
stockholder  meeting. The grant of  such rights, which are  made with respect to
1,858,776 optioned shares shall be in addition to, and shall not count  against,
the  aggregate and annual limits  on the number of  shares with respect to which
other awards under  the Plan  may be  made to  all individuals  and/or a  single
individual.
 
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