ALPHA 1 BIOMEDICALS INC
SC 13D, 2000-11-07
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                             (Amendment No. ______)*


                            Alpha 1 Biomedicals, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, Par Value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   020 910 105
                        --------------------------------
                                 (CUSIP Number)

                               Allan L. Goldstein
                          c/o Alpha 1 Biomedicals, Inc.
          3 Bethesda Metro Center, Suite 700, Bethesda, Maryland 20814
                                 (301) 961-1992
 -------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 August 16, 1999
 -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g),  check
the following box __.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>

CUSIP NO. 020 910 105       13D

1     NAME OF REPORTING PERSON
      S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
      (ENTITIES ONLY)

      Allan L. Goldstein
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

      (a) ___     (b) X
--------------------------------------------------------------------------------
3     SEC USE ONLY
--------------------------------------------------------------------------------
4     SOURCE OF FUNDS

      PF, OO
--------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
      REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)                __
--------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
               7   SOLE VOTING POWER
NUMBER OF          2,249,285
SHARES         -----------------------------------------------------------------
BENEFICIALLY   8   SHARED VOTING POWER
OWNED BY           93,206
EACH           -----------------------------------------------------------------
REPORTING      9   SOLE DISPOSITIVE POWER
PERSON WITH        2,249,285
               -----------------------------------------------------------------
               10  SHARED DISPOSITIVE POWER
                   93,206
--------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING PERSON

     2,342,491
--------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
     CERTAIN SHARES

--------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     12.03%
--------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON

     IN
--------------------------------------------------------------------------------



                                     2 of 7


<PAGE>

Item 1.     Security and Issuer

     The class of equity  securities  to which  this  statement  relates  is the
common  stock,  par value  $0.001 per share  (the  "Common  Stock"),  of Alpha 1
Biomedicals,  Inc. (the  "Company"),  located at 3 Bethesda Metro Center,  Suite
700, Bethesda, Maryland 20814.

Item 2.     Identity and Background

     The name and business  address of the person filing this statement is Allan
L. Goldstein, c/o Alpha 1 Biomedicals, Inc., 3 Bethesda Metro Center, Suite 700,
Bethesda,  Maryland  20814.  Dr.  Goldstein is the President and Chief Executive
Officer of the  Company,  at the  address  stated  above,  and a  Professor  and
Chairman  of the  Department  of  Biochemistry  and  Microbiology  at The George
Washington  University  School of Medicine and Health Sciences.  During the last
five  years,  Dr.  Goldstein  has not been  convicted  in a criminal  proceeding
(excluding  traffic  violations or similar  misdemeanors),  or been a party to a
civil proceeding of a judicial or administrative body of competent  jurisdiction
which  resulted  in him being  subject  to a  judgment,  decree  or final  order
enjoining future violations of, or prohibiting or mandating  activities  subject
to, federal or state securities laws or being found in violation with respect to
such laws.

     Dr. Goldstein is a citizen of the United States of America.

Item 3.     Source and Amount of Funds or Other Consideration

     Dr.  Goldstein  has acquired  beneficial  ownership of 2,342,491  shares of
Common Stock as follows:

     (i) Dr.  Goldstein is a party to a Consulting  Agreement  with the Company,
dated August 16, 1999,  pursuant to which Dr.  Goldstein and three other persons
render financial and business  consulting services and advice to the Company and
are  managing  the  Company's  affairs  on an  interim  basis.  As  part  of the
compensation  paid to him for his services under the Consulting  Agreement,  Dr.
Goldstein  was granted on August 16, 1999 an  immediately  exercisable  ten-year
option (the "Option") to purchase  1,875,000  shares of the Company Common Stock
at an exercise price of $0.04 per share, the fair market value per share on that
date.  On February 3, 2000,  Dr.  Goldstein  exercised  the Option in full.  The
Company  accepted from Dr.  Goldstein as payment of the $75,000 exercise price a
promissory  note  payable to the Company  (the  "Note") in the amount of $75,000
accruing  interest  at 6.09%  per  annum  and  payable  quarterly  for 36 months
beginning  June 1, 2000.  Pursuant to the Stock Pledge and  Security  Agreement,
dated  February 18,  2000,  between Dr.  Goldstein  and the Company (the "Pledge
Agreement"), the Note is secured by the 1,875,000 shares of Company Common Stock
issued to Dr. Goldstein upon exercise of the Option;

     (ii) 374,285  shares  purchased  from time to time prior to August 16, 1999
using personal funds; and

     (iii) 93,206  shares  purchased  from time to time prior to August 16, 1999
using personal funds and held in the name of Dr. Goldstein's wife.


                                     3 of 7

<PAGE>


Item 4.     Purpose of Transaction

     The Option was granted to Dr.  Goldstein as  compensation  for his services
under the Consulting  Agreement,  and exercised by him for investment  purposes.
Dr. Goldstein may from time to time,  depending upon market conditions and other
investment  considerations,  purchase  additional shares of the Common Stock for
investment or dispose of shares of the Common Stock. As a director and President
and Chief Executive Officer of the Company,  Dr. Goldstein may explore potential
actions and  transactions  which may be advantageous to the Company,  including,
but not limited to, possible  mergers,  acquisitions,  reorganizations  or other
material changes in the business,  corporate  structure,  management,  policies,
governing  instruments,  capitalization,  securities  or regulatory or reporting
obligations of the Company.

     Dr.  Goldstein and the other  consultants  under the  Consulting  Agreement
recommended  that the Board adopt  amendments  to the Company's  certificate  of
incorporation  to increase the number of authorized  shares of Common Stock from
20,000,000 to  100,000,000  and to change the Company's  corporate  name;  these
amendments were approved by the Board on August 10, 2000, with Dr.  Goldstein as
a director  voting in favor of both  amendments,  and will be  submitted  to the
Company's  stockholders  for their approval at an annual meeting of stockholders
to be held on December 15, 2000 (the  "Meeting").  Dr.  Goldstein  and the other
consultants  also  recommended  that the Board  adopt a 2000  Stock  Option  and
Incentive  Plan  providing  for the grant of options  covering  up to  1,000,000
shares of Common  Stock;  the plan was approved by the Board on August 10, 2000,
with Dr.  Goldstein  as a  director  voting  in favor of the  plan,  and will be
submitted to the Company's stockholders for their approval at the Meeting.

     Except as noted above, Dr. Goldstein has no plans or proposals which relate
to or would result in:

     (a) the acquisition by any person of additional  securities of the Company,
or the disposition of securities of the Company;

     (b)  an   extraordinary   corporate   transaction,   such   as  a   merger,
reorganization or liquidation, involving the Company or any of its subsidiaries;

     (c) a sale or transfer of a material amount of assets of the Company or any
of its subsidiaries;

     (d) any change in the  present  Board of  Directors  or  management  of the
Company,  including  any  plans or  proposals  to change  the  number or term of
directors or to fill any existing vacancies on the Board;

     (e) any material change in the present capitalization or dividend policy of
the Company;

     (f) any  other  material  change in the  Company's  business  or  corporate
structure;

     (g)  changes  in the  Company's  certificate  of  incorporation,  bylaws or
instruments  corresponding  thereto  or  other  actions  which  may  impede  the
acquisition of control of the Company by any person;

                                     4 of 7

<PAGE>

     (h) causing a class of  securities  of the  Company to be  delisted  from a
national  securities  exchange or to cease to be  authorized  to be quoted in an
inter-dealer quotation system of a registered national securities association;

     (i) a class of equity  securities  of the  Company  becoming  eligible  for
termination  of  registration  pursuant to Section  12(g)(4)  of the  Securities
Exchange Act of 1934; or

     (j) any action similar to any of those enumerated above.


Item 5.     Interest in Securities of the Issuer

     The aggregate  number of shares of Common Stock  beneficially  owned by Dr.
Goldstein  as of the  date of this  filing  is  2,342,491  shares,  representing
approximately  12.03% of the shares of Common Stock currently  outstanding.  Dr.
Goldstein has sole voting and dispositive powers over 2,249,285 of these shares.
The  remaining  93,206 shares are held by Dr.  Goldstein's  wife with respect to
which Dr. Goldstein shares voting and dispositive powers.

     Mrs. Goldstein's address is c/o Alpha 1 Biomedicals, Inc., 3 Bethesda Metro
Center,  Suite 700, Bethesda,  Maryland 20814.  During the last five years, Mrs.
Goldstein has not been  convicted in a criminal  proceeding  (excluding  traffic
violations or similar misdemeanors),  or been a party to a civil proceeding of a
judicial or administrative body of competent  jurisdiction which resulted in her
being subject to a judgment,  decree or final order enjoining future  violations
of,  or  prohibiting  or  mandating  activities  subject  to,  federal  or state
securities laws or being found in violation with respect to such laws.

     Mrs. Goldstein is a citizen of the United States of America.

     During the 60-day  period  prior to the date of this  filing,  Dr. and Mrs.
Goldstein did not effect any transactions in the Common Stock.

     No person other than Dr. Goldstein is known to have the right to receive or
the power to direct the receipt of dividends from, or the proceeds from the sale
of, the shares  beneficially  owned by Dr.  Goldstein,  except the 93,206 shares
held by Dr.  Goldstein's wife and the 1,875,000 shares acquired by Dr. Goldstein
upon exercise of the Option, as explained below.

     Under the Pledge  Agreement,  Dr.  Goldstein has pledged as collateral  for
repayment of the Note the 1,875,000  shares acquired by him upon exercise of the
Option. The Pledge Agreement provides that Dr. Goldstein will not be entitled to
receive  cash  dividends  paid  on the  pledged  shares  if he  defaults  on his
obligation  to repay the Note or if certain  other  events of default  under the
Pledge  Agreement  occur and  continue.  All  non-cash  dividends on the pledged
shares are considered collateral securing the Note and must be held in trust for
the benefit of the Company. Dr. Goldstein may not sell any of the pledged shares
without the Company's consent, and any proceeds from sales constitute collateral
under the Pledge Agreement.


                                     5 of 7

<PAGE>


Item 6.     Contracts, Arrangements, Understandings or
            Relationships with Respect to the Securities of
            the Issuer

     Other than the  Consulting  Agreement,  the Note and the Pledge  Agreement,
there are no contracts, arrangements,  understandings or relationships (legal or
otherwise)  between Dr.  Goldstein and any person with respect to any securities
of the Company,  including but not limited to, transfer or voting of any of such
securities,  finder's fees, joint ventures, loan or option arrangements, puts or
calls,  guarantees  of profits,  divisions of profits or loss,  or the giving or
withholding of proxies.

Item 7.     Material to be Filed as Exhibits

         Exhibit 1:               Promissory Note, dated February 3, 2000,
                                  payable by Allan L. Goldstein to the Company.

         Exhibit 2:               Stock Pledge and Security Agreement, dated
                                  February 18, 2000, between Allan L. Goldstein
                                  and the Company.







                                     6 of 7

<PAGE>

                                    SIGNATURE


     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Date: November 7, 2000             /s/ Allan L. Goldstein
      -------------------          ------------------------
                                   Allan L. Goldstein





<PAGE>

                                   EXHIBIT 1

<PAGE>

                                 PROMISSORY NOTE


$ 75,000.00                                                   Bethesda, Maryland
                                                                February 3, 2000


         FOR VALUE RECEIVED, I, ALLAN L. GOLDSTEIN (the "Borrower"),  promise to
pay to the order of ALPHA 1  BIOMEDICALS,  INC.,  a  Delaware  corporation,  its
successors  and assigns (the  "Lender"),  the Principal  Amount of  Seventy-five
Thousand Dollars ($75,000.00) (the "Principal  Amount"),  together with interest
thereon at the rate hereinafter provided, in accordance with the following terms
and provisions:

         1. Stock  Pledge and  Security  Agreement.  This Note is subject to the
terms and  conditions  of the Stock Pledge and  Security  Agreement of even date
herewith  by and among the  Lender  and the  Borrower  (the  "Stock  Pledge  and
Security Agreement"),  as may from time to time be extended,  amended, restated,
supplemented or otherwise  modified.  The term "Financing  Documents" as used in
this Note  shall mean  collectively  this Note,  the Stock  Pledge and  Security
Agreement  and  any  other  instrument,   agreement,   or  document  previously,
simultaneously,  or hereafter  executed and delivered by the Borrower and/or any
other person, singularly or jointly with any other person, evidencing, securing,
guaranteeing,  or in  connection  with this Note  and/or  the Stock  Pledge  and
Security Agreement.

         2. Interest.  Amounts outstanding  hereunder shall bear interest during
the term hereof at the annual rate equal to Six and 9/100 Percent (6.09%).

         3.  Payments  and  Maturity.  Interest  only  shall be due and  payable
quarterly  beginning on June 1, 2000,  and on the first day of every third (3rd)
month  thereafter  until  the  Principal  Amount  is paid in  full.  The  unpaid
Principal Amount, together with all accrued and unpaid interest thereon shall be
due and payable in full three (3) years from the date hereof.

         4.  Prepayments.  The Borrowers shall have the right to prepay all or a
portion of the unpaid Principal Amount at any time without penalty.

         5. Default  Interest.  Upon the  occurrence  of an Event of Default (as
hereinafter defined), the unpaid Principal Amount shall bear interest thereafter
at an annual rate equal to the maximum interest rate allowable by applicable law
(the "Default Rate") until such Event of Default is cured.

         6. Application and Place of Payments.  All payments  hereunder shall be
applied  first to the  payment of any costs of  collection  then due  hereunder,
second to the payment of accrued and unpaid interest then due hereunder, and the
remainder, if any, shall be applied to the unpaid Principal Amount. All payments
on account of this Note  shall be paid in lawful  money of the United  States of
America in immediately  available funds at the principal office of the Lender or
at such  other  place  as the  Lender  may at any  time  and  from  time to time
designate in writing to the Borrower.

                                        1

<PAGE>



         7. Security.  This Note is secured by the  collateral  described in the
Stock Pledge and Security Agreement.

         8.  Events  of  Default.  The  occurrence  of any  one or  more  of the
following events shall constitute an event of default  (individually,  an "Event
of Default" and  collectively,  the "Events of Default") under the terms of this
Note:

                  (a) the failure of the  Borrower  to pay to the Lender  within
five (5) days of when due any and all  amounts  payable by the  Borrower  to the
Lender under the terms of this Note;

                  (b) if a petition in bankruptcy is filed by the Borrower under
the U.S.  Bankruptcy Code, as amended, or under any other insolvency law or laws
providing for the relief of debtors;

                  (c) if the  Borrower  becomes  insolvent or executes a general
assignment  for the  benefit of  creditors  or if any  appointment  is made of a
receiver or trustee for the property of the Borrower;

                  (d) if a petition is filed against the Borrower under the U.S.
Bankruptcy  Code, as amended,  and is not  dismissed  within ninety (90) days of
filing; or

                  (e) the  occurrence  of an  event  of  default  which  remains
uncured  beyond  any  applicable  grace  or cure  period  under  the  terms  and
conditions of any of the other Financing Documents.

         9. Remedies.  Upon the occurrence of an Event of Default, at the option
of the Lender, all amounts payable by the Borrower to the Lender under the terms
of this Note shall  immediately  become due and  payable by the  Borrower to the
Lender  without  further  notice to the Borrower,  or any other person,  and the
Lender shall have all of the rights,  powers,  and remedies  available under the
terms of this Note,  any of the other  Financing  Documents  and all  applicable
laws.  The Borrower  hereby  severally  waive  presentment,  protest and demand,
notice of protest, notice of demand and of dishonor and non-payment of this Note
and expressly agree that this Note or any payment hereunder may be extended from
time to time without in any way affecting  the  liability of the  Borrower.  The
holder  hereof  shall have the right to recover  its damages  hereunder  only as
provided in Article VI of the Stock Pledge and Security Agreement. The rights of
the Lender  hereunder in the Event of Default are without  recourse  against the
Borrower, and the Lender's sole source for the recovery of its damages hereunder
shall be the collateral  securing the repayment of this Note, as provided in the
Stock Pledge and Security Agreement.

         10.  Expenses.  Subject to the  provisions  of  Paragraph 9 above,  the
Borrower  promises  to pay to the  Lender on demand by the  Lender all costs and
expenses incurred by the Lender after an Event of Default in connection with the
collection  and  enforcement  of  this  Note,  including,   without  limitation,
reasonable attorneys' fees and expenses and all court costs.


                                        2

<PAGE>



         11. Notices. Any notice,  request, or demand to or upon the Borrower or
the Lender shall be deemed to have been properly given or made when delivered in
accordance  with  the  notice  provisions  of  the  Stock  Pledge  and  Security
Agreement.

         12.  Miscellaneous.  Each  right,  power,  and  remedy of the Lender as
provided  for in this Note or any of the other  Financing  Documents,  or now or
hereafter existing under any applicable law or otherwise shall be cumulative and
concurrent  and shall be in  addition  to every other  right,  power,  or remedy
provided  for in this Note or any of the  other  Financing  Documents  or now or
hereafter  existing under any  applicable  law, and the exercise or beginning of
the  exercise  by the  Lender  of any one or more of  such  rights,  powers,  or
remedies shall not preclude the  simultaneous or later exercise by the Lender of
any or all such other rights,  powers,  or remedies.  No failure or delay by the
Lender to insist upon the strict performance of any term,  condition,  covenant,
or  agreement  of  this  Note or any of the  other  Financing  Documents,  or to
exercise any right,  power, or remedy  consequent  upon a breach thereof,  shall
constitute a waiver of any such term,  condition,  covenant,  or agreement or of
any such breach,  or preclude the Lender from exercising any such right,  power,
or remedy at a later time or times.  By accepting  payment after the due date of
any amount  payable under the terms of this Note, the Lender shall not be deemed
to waive  the right  either  to  require  prompt  payment  when due of all other
amounts  payable  under the terms of this Note or to declare an Event of Default
for the  failure to effect  such  prompt  payment of any such other  amount.  No
course of  dealing  or  conduct  shall be  effective  to amend,  modify,  waive,
release, or change any provisions of this Note.

         13. Partial Invalidity. In the event any provision of this Note (or any
part  of any  provision)  is held by a court  of  competent  jurisdiction  to be
invalid, illegal, or unenforceable in any respect, such invalidity,  illegality,
or  unenforceability  shall not affect any other provision (or remaining part of
the  affected  provision)  of this Note;  but this Note shall be construed as if
such invalid, illegal, or unenforceable provision (or part thereof) had not been
contained  in this  Note,  but only to the  extent it is  invalid,  illegal,  or
unenforceable.

         14.  Captions.  The captions herein set forth are for convenience  only
and shall not be deemed to define,  limit,  or  describe  the scope or intent of
this Note.

         15. Applicable Law. The Borrower acknowledges and agrees that this Note
shall be governed by the laws of the State of  Maryland,  without  regard to its
choice of law rules, even though,  for the convenience and at the request of the
Borrower, this Note may be executed elsewhere.

         16. Prior Payment Set Aside.  The Borrower  agrees that, if any payment
made by the  Borrower or any other  person is applied to this Note and is at any
time annulled, set aside, rescinded,  invalidated,  declared to be fraudulent or
preferential or otherwise  required to be refunded or repaid, or the proceeds of
any property  hereafter securing this Note is required to be refunded or repaid,
or the proceeds of any property  hereafter  securing this Note is required to be
returned by the Lender to the  Borrower,  its estate,  trustee,  receiver or any
other party, including,  without imitation,  the Borrower,  under any bankruptcy
law, state or federal law, common law or equitable cause, then, to the extent of
such payment or repayment  the  Borrower's  liability  hereunder  (and any lien,
security

                                        3

<PAGE>



interest or other  collateral  securing such  liability)  shall be and remain in
full force and effect as fully as if such  payment  had never been made,  or, if
prior thereto any such lien,  security  interest or other  collateral  hereafter
securing  the  Borrower's  liability  hereunder  shall  have  been  released  or
terminated  by virtue of such  cancellation  or  surrender,  this Note (and such
lien,  security  interest or other collateral) shall be reinstated in full force
and  effect,  and such  prior  cancellation  or  surrender  shall not  diminish,
release,  discharge,  impair or otherwise affect the obligations of the Borrower
in respect of the amount of such  payment  (or any lien,  security  interest  or
other collateral securing such obligation).

         17.  Liabilities  Unconditional.  The obligations of the Borrower under
this Note shall be absolute, irrevocable and unconditional,  and shall remain in
full force and effect  until the  outstanding  principal of and interest on this
Note and all other  obligations  or amounts  due  hereunder  and under the Stock
Pledge  and  Security  Agreement  shall have been  indefeasibly  paid in full in
accordance with their respective terms and this Note shall have been canceled.

         18.  WAIVER OF TRIAL BY JURY.  THE BORROWER AND THE LENDER HEREBY WAIVE
TRIAL BY JURY IN ANY ACTION OR  PROCEEDING  TO WHICH THE BORROWER AND THE LENDER
MAY BE PARTIES, ARISING OUT OF OR IN ANY WAY PERTAINING TO (A) THIS NOTE, OR (B)
THE  FINANCING  DOCUMENTS.   IT  IS  AGREED  AND  UNDERSTOOD  THAT  THIS  WAIVER
CONSTITUTES A WAIVER OF TRIAL BY JURY OF ALL CLAIMS  AGAINST ALL PARTIES TO SUCH
ACTIONS OR PROCEEDINGS,  INCLUDING CLAIMS AGAINST PARTIES WHO ARE NOT PARTIES TO
THIS NOTE.  THIS WAIVER IS  KNOWINGLY,  WILLINGLY  AND  VOLUNTARILY  MADE BY THE
BORROWER,  AND THE BORROWER HEREBY REPRESENTS THAT NO REPRESENTATIONS OF FACT OR
OPINION HAVE BEEN MADE BY ANY  INDIVIDUAL TO INDUCE THIS WAIVER OF TRIAL BY JURY
OR TO IN ANY WAY MODIFY OR NULLIFY ITS EFFECT.  THE BORROWER FURTHER  REPRESENTS
THAT HE HAS BEEN  REPRESENTED  IN THE  SIGNING OF THIS NOTE AND IN THE MAKING OF
THIS WAIVER BY  INDEPENDENT  LEGAL  COUNSEL,  SELECTED OF HIS OWN FREE WILL, AND
THAT HE HAS HAD THE OPPORTUNITY TO DISCUSS THIS WAIVER WITH COUNSEL.


         IN WITNESS  WHEREOF,  the  Borrower has  executed  and  delivered  this
Promissory Note under seal as of the day and year first written above.


WITNESS:


/s/ Brian L. Alpert                          /s/ Allan L. Goldstein       (SEAL)
-------------------                          -----------------------------------
                                              Allan L. Goldstein


                                        4

<PAGE>



                           )
District of Columbia       )        ss:
                           )

     I HEREBY CERTIFY that on this 18th day of February,  2000,  before me, the
subscriber,  a Notary Public in and for the jurisdiction  aforesaid,  personally
appeared ALLAN L. GOLDSTEIN, who is known (or satisfactorily proven) to me to be
the person whose name is subscribed to the foregoing instrument and acknowledged
that he freely and voluntarily executed the same for the purposes therein.

         WITNESS my hand and notarial seal.
                                                    /s/ Noemi C. Taylor
                                                  ------------------------------
                                                         NOTARY PUBLIC

                         Noemi C. Taylor
                         Notary Public District Columbia
My Commission Expires:   12/14/2004



                                        5



<PAGE>
                                   EXHIBIT 2

<PAGE>

                       STOCK PLEDGE AND SECURITY AGREEMENT

     THIS STOCK PLEDGE AND SECURITY  AGREEMENT  (this  "Agreement") is made this
18th day of February,  2000, by and between ALLAN L. GOLDSTEIN  (the  "Pledgor")
and ALPHA 1 BIOMEDICALS, INC., a Delaware corporation (the "Lender").

                                    RECITALS

     The Lender has approved the  acceptance  of payment for the exercise by the
Pledgor of his option to purchase  1,875,000  shares of the common  stock of the
Lender at an exercise  price of $0.04 per share in the form of a note payable in
the amount of $75,000.00  to the Lender,  provided that the Pledgor grant to the
Lender a continuing  security  interest in and to the  Collateral  (as hereafter
defined) to secure the payment of the Obligations (as hereinafter defined); and

     The  Pledgor  did, on  February  3, 2000,  exercise  his option to purchase
1,875,000 shares of the common stock of the Lender at an exercise price of $0.04
per share and pay the exercise price by delivering  his  promissory  note in the
amount of $75,000.00 to the Lender.

     NOW THEREFORE, in consideration of the premises and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
Pledgor and the Lender agree as follows:

                                    ARTICLE I
                      DEFINITIONS AND RULES OF CONSTRUCTION

     1.01.  Definitions.  The  terms  defined  in the  Preamble  shall  have the
respective  meanings specified  therein,  and the following terms shall have the
following meanings:

     "Collateral" has the meaning set forth in Section 2.01.

     "Default" has the meaning set forth in Article V.

     "Enforcement Costs" means any and all funds, costs, expenses and charges of
any nature whatsoever (including, without limitation, reasonable attorney's fees
and expenses) advanced,  paid or incurred by or on behalf of the Lender under or
in  connection  with  the  enforcement  of this  Agreement,  including,  without
limitation,  (a) the  compliance  of the Pledgor  with any  covenant,  warranty,
representation or agreement of the Pledgor made in or pursuant to this Agreement
or any of the other  Financing  Documents,  (b) the collection or enforcement of
any of the Obligations, this Agreement and any of the other Financing Documents,
and  (c)  the  exercise,  preservation,   maintenance,   protection,  operation,
management,  collection,  sale or other disposition of, or realization upon, all
or any part of the Collateral, the Security Interest and the rights and remedies
of the Lender hereunder,  under the other Financing Documents,  under applicable
law or otherwise.

     "Event of Default"  means an event which,  with the giving of notice or the
lapse of time, or both, could or would constitute a Default under the provisions
of this Agreement.

                                        1

<PAGE>



     "Financing  Documents" means collectively this Agreement,  the Note and any
other instrument, document or agreement previously,  simultaneously or hereafter
executed and  delivered by the Pledgor  and/or any other  person,  singularly or
jointly  with  any  other  person,  evidencing,  securing,  guaranteeing  or  in
connection with the Note and/or this Agreement.

     "Note" means that certain promissory note of even date herewith made by the
Pledgor in favor of the Lender.

     "Obligations"  means  collectively the obligations of the Pledgor under the
Financing Documents.

     "Pledged Stock" has the meaning set forth in Section 2.01.

     "Security Interests" means the security interests in the Collateral granted
hereunder.

     "UCC" means the Uniform  Commercial  Code as in effect from time to time in
the State of Maryland.

     1.02. Rules of Construction. Unless otherwise defined herein and unless the
context otherwise  requires,  all terms used herein which are defined by the UCC
shall  have the same  meanings  assigned  to them by the UCC  unless  and to the
extent varied by this Agreement.  The words "hereof",  "herein", and "hereunder"
and words of similar  import  when used in this  Agreement  shall  refer to this
Agreement as a whole and not to any particular provision of this Agreement,  and
section, subsection,  schedule and exhibit references are references to sections
or  subsections  of, or  schedules  or  exhibits  to,  as the case may be,  this
Agreement unless otherwise specified.  As used herein, the singular number shall
include  the  plural,  the plural the  singular,  and the use of the  masculine,
feminine or neuter gender shall include all genders, as the context may require.

                                   ARTICLE II
                                 THE COLLATERAL

     2.01. The Pledge.  In order to secure the full and punctual  payment of the
Obligations in accordance with the terms thereof,  and to secure the performance
of  this  Agreement  and the  other  Financing  Documents,  the  Pledgor  hereby
transfers,  pledges,  assigns,  sets over,  delivers  and grants to the Lender a
continuing lien and security interest in and to all of the following property of
the Pledgor,  both now owned and existing and  hereafter  created,  acquired and
arising (all being collectively  referred to as the "Collateral") and all right,
title and interest of the Pledgor in and to the Collateral:

                  (a)  Pledged  Stock,   Etc.  (i)  One  Million  Eight  Hundred
Seventy-five  Thousand (1,875,000) shares of the common stock of the Lender (the
"Pledged Stock"),  (ii) any certificates  representing or evidencing the Pledged
Stock,  (iii)  subject to Section  2.05  below,  all  payments of  principal  or
interest,  dividends, cash, income, profits,  instruments,  securities and other
property from

                                        2

<PAGE>



time to time  received,  receivable or otherwise  distributed  in respect of, in
exchange for or upon  conversion of the Pledged  Stock,  and (iv) subject to the
provisions of Section 2.05 hereof,  any and all voting and other rights,  powers
and  privileges  accruing or incidental to an owner of the Pledged Stock and the
other  property  referred to in  subclauses  (i) through  (iii) of this  Section
2.01(a); and

                  (b) Proceeds.  All cash and non-cash  proceeds and products of
the Collateral.

     2.02.  Security  Interests as Security  Only.  The Security  Interests  are
granted as security  only and shall not  subject  the Lender to transfer  taxes,
fees or similar  assessments  or in any way affect or modify any  obligation  or
liability  of  the  Pledgor  with  respect  to  any  of  the  Collateral  or any
transaction in connection therewith.

     2.03.  Delivery,  Etc. The Pledgor  shall  deliver or promptly  cause to be
delivered to the Lender (a) all  certificates  representing  or  evidencing  the
Pledged Stock which shall be accompanied by undated and irrevocable stock powers
duly executed in blank by the Pledgor,  and (b) all other property,  instruments
and papers  comprising,  representing  or evidencing  the Collateral or any part
thereof  accompanied by proper  instruments  of assignment or  endorsement  duly
executed by the Pledgor.

     2.04. Record Owner of Stock Collateral.  The Lender shall have the right in
its  sole  and  absolute  discretion  to hold  any  stock  certificates,  notes,
instruments or securities now or hereafter included in the Collateral in its own
name,  the name of its  nominee or the name of the  Pledgor.  The  Pledgor  will
promptly  give to the  Lender  copies  of any  notices  or other  communications
received  by it with  respect to  Pledged  Stock  registered  in the name of the
Pledgor.

     2.05. Voting Rights; Dividends and Interest; etc.

           (a)      Unless and until an Event of Default shall have occurred and
 is continuing:

                   (i)      The Pledgor shall be entitled to exercise any and
all voting and other rights,  powers and privileges  accruing to an owner of the
Pledged Stock or any part thereof for any purpose consistent with the terms of
this Agreement and the other  Financing  Documents;  provided,  however,  that
such  action  would not materially  and adversely  affect the rights  inuring to
a holder of the Pledged Stock or materially  and adversely  affect the rights
and remedies of the Lender under this Agreement or the ability of the Lender to
exercise the same.

                   (ii)     The Lender shall execute and deliver to the Pledgor,
or cause to be executed and delivered to the Pledgor, all such proxies,  powers
of attorney and other instruments as the Pledgor may reasonably  request for the
purpose of enabling the Pledgor to exercise the voting and other rights,  powers
and privileges which he is entitled to exercise pursuant to subparagraph (i) of
this Section 2.05(a).


                                        3

<PAGE>



                           (iii) The  Pledgor  shall be  entitled to receive and
retain any and all cash
dividends  paid on the  Pledged  Stock to the extent and only to the extent that
such cash dividends are permitted by, and otherwise paid in accordance with, the
terms and  conditions of applicable  laws.  All noncash  dividends and dividends
paid or  payable  in cash or  otherwise  in  connection  with a partial or total
liquidation or  dissolution  of the issuer of the Pledged  Stock,  and all other
distributions (other than pursuant to the first sentence of this clause) made on
or in respect of Pledged  Stock,  whether paid or payable in cash or  otherwise,
whether  resulting from a subdivision,  combination or  reclassification  of the
outstanding  capital  stock of the issuer of the  Pledged  Stock or  received in
exchange for Pledged Stock or any part thereof,  or in redemption  thereof, as a
result of any merger, consolidation,  acquisition or other exchange of assets to
which such issuer may be a party or  otherwise,  shall be and become part of the
Collateral,  and, if received by the  Pledgor,  shall not be  commingled  by the
Pledgor with any of his other funds or property  but shall be held  separate and
apart  therefrom  in trust for the benefit of the Lender and shall be  forthwith
delivered  to the  Lender in the same form as so  received  (with any  necessary
endorsement reasonably required by the Lender).

                  (b) Upon the occurrence and during the continuance of an Event
of Default, all rights of the Pledgor to dividends and other distributions which
the Pledgor is  authorized to receive  pursuant to Section 2.05 (a)(iii)  hereof
shall cease,  and all such rights shall  thereupon  become vested in the Lender,
which  shall have the sole and  exclusive  right and  authority  to receive  and
retain  such  dividends  and  other  distributions.   All  dividends  and  other
distributions  which are received by the Pledgor  contrary to the  provisions of
this Section  2.05(b) shall be received and held in trust by the Pledgor for the
benefit of the Lender,  the Pledgor  shall  segregate  such  dividends and other
distributions from other property or funds of the Pledgor, and the Pledgor shall
immediately  deliver such dividends and other distributions to the Lender in the
same form as so received (with any necessary endorsement  reasonably required by
the Lender).  Any and all money and other  property  paid over to or received by
the Lender  pursuant to the provisions of this Section 2.05(b) shall be retained
by the Lender in an account to be established by the Lender upon receipt of such
money or other  property and shall be applied to the  Obligations  in accordance
with the provisions of this Agreement.

                  (c) Upon the occurrence and during the continuance of an Event
of Default,  all rights of the Pledgor to exercise the voting and other  rights,
powers and  privileges  which it is  entitled  to  exercise  pursuant to Section
2.05(a)(i) hereof shall cease, and all such rights,  powers and privileges shall
thereupon  become vested in the Lender,  which shall have the sole and exclusive
right and  authority  to  exercise  such  voting  and other  rights,  powers and
privileges.

     2.06.  Release  of  Pledged  Stock  and other  Collateral.  When all of the
Obligations have been indefeasibly paid in full and no commitments  therefor are
outstanding,  the Lender  will  reassign  and  deliver to the  Pledgor,  against
receipt,  all of the Collateral as is then being held by the Lender (if any) and
not sold or otherwise  applied by the Lender  pursuant to the terms hereof.  Any
such reassignment  shall be without recourse to or warranty by the Lender at the
expense of the Pledgor.


                                        4

<PAGE>



                                   ARTICLE III
                  REPRESENTATIONS AND WARRANTIES OF THE PLEDGOR

     3.01. Representations and Warranties of the Pledgor. The Pledgor represents
and warrants to the Lender that the following  statements are true,  correct and
complete:

                  (a)  Title  and  Authority:  The  Pledgor  is the owner of the
Collateral and has good and marketable title to the Collateral free and clear of
any liens, claims or encumbrances (other than as created by this Agreement). The
Pledgor has full power and  authority  to grant the  Security  Interests  to the
Lender in the Collateral pursuant hereto and to execute, deliver and perform his
obligations in accordance  with the terms of this Agreement  without the consent
or approval of any person,  natural or legal, other than any consent or approval
which has been obtained.

                  (b) No Restriction of Rights.  The Pledgor is not and will not
become party to or otherwise bound by any agreement,  other than this Agreement,
which  restricts in any manner the rights of any present or future holder of any
of the Pledged Stock.

                  (c) Validity, Perfection and Priority of Security Interest. By
virtue of the execution and delivery of this  Agreement and upon delivery to the
Lender  of the  Pledged  Stock (or  certificates,  instruments  or other  papers
representing  or evidencing the Pledged Stock) in accordance with the provisions
of this Agreement,  the Lender will have a valid and perfected security interest
in and to the Pledged Stock subject to no prior or other  security  interests or
other liens. No registration,  recordation or filing with any governmental body,
agency or official is required in connection  with the execution and delivery of
this Agreement or necessary for the validity or enforceability of this Agreement
or for the perfection of the Security Interests.

                  (d) Survival.  All representations and warranties contained in
or made  under or in  connection  with  this  Agreement  (a) shall  survive  the
execution,  delivery and performance of this  Agreement,  and (b) shall be true,
correct  and  complete  at all times  during  which any of the  Obligations  (or
commitments   therefor)  are  outstanding  with  the  same  effect  as  if  such
representations and warranties had been made at such times.

                                   ARTICLE IV
                              COVENANTS OF PLEDGOR

     4.01.  Covenants of the Pledgor.  The Pledgor covenants and agrees with the
Lender as follows:

                  (a) Title, Liens and Taxes. The Pledgor shall, at his cost and
expense,  take  any and  all  actions  necessary  to  defend  his  title  to the
Collateral  against  all persons and to defend the  Security  Interests  and the
priority (or intended priority) thereof,  against any adverse lien of any nature
whatsoever.  Except to the extent  contested in good faith, the Pledgor will pay
all taxes and

                                        5

<PAGE>



assessments  levied  or  placed  on the  Collateral  prior to the date  when any
interest or penalty would accrue for the nonpayment thereof.

                  (b) Further Assurances.  The Pledgor shall, from time to time,
at his  expense,  execute,  deliver,  acknowledge  and  cause to be duly  filed,
recorded or  registered  any  statement,  assignment,  endorsement,  instrument,
paper,  agreement or other  document and take any other action that from time to
time may be necessary or desirable,  or that the Lender may reasonably  request,
in order to  create,  preserve,  continue,  perfect,  confirm  or  validate  the
Security  Interests or to enable the Lender to obtain the full  benefits of this
Agreement  or to exercise  and enforce  any of its rights,  powers and  remedies
hereunder.  The Pledgor shall pay all costs of, and  incidental  to, the filing,
recording or  registration  of any such  documents  as well as any  recordation,
transfer or other tax  required to be paid in  connection  with any such filing,
recordation or  registration.  The Pledgor hereby covenants to hold harmless and
indemnify the Lender from and against any liability  resulting  from the failure
to pay any required  documentary  stamps,  recordation  and  transfer  taxes and
recording costs incurred by the Lender in connection  with this  Agreement,  and
such covenant shall survive the termination of this Agreement and the payment of
all  other  Obligations.   The  Pledgor  agrees  that  a  carbon,  photographic,
photostatic or other reproduction of this Agreement or of a financing  statement
signed by the Pledgor in connection with this Agreement shall be sufficient as a
financing statement.

                  (c) Care and  Protection  of  Collateral.  The  Pledgor  shall
promptly  notify  the  Lender  of  any  event  causing  deterioration,  loss  or
depreciation  in value of any  substantial  portion  of the  Collateral  and the
amount of such loss or  depreciation.  The Pledgor  shall  perform,  observe and
comply  with all of the  terms  and  provisions  to be  performed,  observed  or
complied with by it under each contract, agreement or obligation relating to the
Collateral.  The Lender shall have no duty, and the Pledgor hereby  releases the
Lender  from all claims for loss or damage  caused by the failure of the Lender,
to  collect,  protect,  preserve or enforce  any of the  Collateral  or preserve
rights against account debtors and prior parties to the Collateral.

                  (d) Sale of  Collateral  and  Additional  Shares.  Without the
prior written consent of the Lender,  the Pledgor will not sell, lease,  assign,
transfer,  dispose  of,  pledge  or  grant  or  permit a lien to exist on or any
interest in the Collateral.

                                    ARTICLE V
                                     DEFAULT

     5.01. Events of Default. The occurrence of any one or more of the following
events shall  constitute a default under the provisions of this  Agreement,  and
the term "Default" shall mean, whenever it is used in this Agreement, any one or
more of the following events:

            (a)      Failure to Pay Obligations When Due.  The failure of the
Pledgor to pay any of the Obligations as and when due and payable in accordance
with the provisions of any of the Financing Documents after giving effect to any
applicable cure or grace periods;

                                        6

<PAGE>



                  (b) Failure to Perform Other  Obligations.  The failure of the
Pledgor to perform,  observe or comply with any of the non-monetary  Obligations
and other  provisions  of this  Agreement  and such  failure is not cured to the
satisfaction  of the Lender  within a period of thirty  (30) days after the date
the Pledgor receives written notice thereof;

                  (c)  Breach  of   Representations   and  Warranties.   If  any
representation  and warranty contained herein or any statement or representation
made in any  certificate  or any other  information  at any time  given by or on
behalf of the Pledgor or furnished in connection  with this  Agreement or any of
the  other  Financing  Documents  shall  prove to be false or  incorrect  in any
material  respect on the date as of which made, and any such  representation  or
warranty  which,  in the  reasonable  opinion  of the Lender is capable of being
cured, is not cured to the satisfaction of the Lender within ten (10) days after
the date the Pledgor receives written notice thereof;

                  (d) Default under Other  Financing  Documents.  The failure of
the Pledgor to perform,  observe or comply with any of the  provisions of any of
the Financing  Documents  (other than this  Agreement) to which the Pledgor is a
party and such failure is not cured within applicable cure or grace periods,  if
any.

                                   ARTICLE VI
                               RIGHTS AND REMEDIES

         6.01. Rights and Remedies of the Lender.  Upon and after the occurrence
of any Event of Default,  the Lender may,  without  notice or demand  other than
expressly  provided for under the provisions of this Agreement,  exercise in any
jurisdiction in which  enforcement  hereof is sought,  the following  rights and
remedies,  which shall be the  exclusive  rights and  remedies  available to the
Lender,  it being the  express  intent of the Lender and the  Borrower  that the
rights and remedies of the Lender  hereunder in the Event of Default are without
recourse against the Borrower and that the Lender's sole source for the recovery
of its damages hereunder shall be the Collateral:

                  (a) The Lender may sell the  Collateral,  or any part thereof,
at  public  or  private  sale  or at any  broker's  board  or on any  securities
exchange,  for cash, upon credit or for future delivery as the Lender shall deem
appropriate, and at such price or prices satisfactory to the Lender; or

                  (b) The  Lender  may  proceed  by a suit or suits at law or in
equity to foreclose  this  Agreement  and to sell the  Collateral or any portion
thereof  pursuant to a judgment or decree of a court or courts having  competent
jurisdiction or pursuant to a proceeding by a court-appointed receiver.

         6.02. Sale of Collateral. If the Lender chooses to sell the Collateral,
then the Lender shall be  authorized  at any such sale (if it deems it advisable
to do so) to  restrict  the  prospective  bidders  or  purchasers  of any of the
Collateral to persons who will  represent and agree that they are purchasing the
Collateral  for  their own  account  for  investment  and not with a view to the
distribution or sale thereof,  and upon consummation of any such sale the Lender
shall have the right to assign, transfer

                                        7

<PAGE>



and deliver to the purchaser or purchasers  thereof the Collateral so sold. Each
such  purchaser at any such sale shall hold the property  sold  absolutely  free
from any  claim or right on the  part of the  Pledgor,  and the  Pledgor  hereby
waives all rights of redemption, stay, valuation and appraisal which the Pledgor
now has or may at any time in the  future  have under any rule of law or statute
now  existing or hereafter  enacted.  The Lender shall give the Pledgor ten (10)
days written  notice (which the Pledgor  agrees is reasonable  notice within the
meaning  of the  UCC) of the  Lender's  intention  to  make  any  sale or  other
disposition  of  Collateral.  Such notice,  in the case of a public sale,  shall
state  the time and  place for such  sale,  in the case of a sale at a  broker's
board or on a  securities  exchange,  shall state the board or exchange at which
such sale is to be made and the day on which the Collateral, or portion thereof,
will first be offered for sale at such board or  exchange  and, in the case of a
private sale or other disposition, shall state the date after which such sale or
other  disposition  may be made. Any such public sale shall be held at such time
or times  within  ordinary  business  hours  and at such  place or places as the
Lenders  may fix and state in the  notice of such sale.  At any such  sale,  the
Collateral, or portion thereof, to be sold may be sold in one lot as an entirety
or in separate parcels, as the Lender may (in its sole and absolute  discretion)
determine.  The Lender shall not be obligated to make any sale of any Collateral
if it shall  determine not to do so,  regardless of the fact that notice of sale
of such  Collateral  shall have been given.  The Lender may,  without  notice or
publication,  adjourn  any  public  or  private  sale or  cause  the  same to be
adjourned  from time to time by  announcement  at the time and  place  fixed for
sale, and such sale may,  without further notice,  be made at the time and place
to which the same was so  adjourned.  In case any sale of all or any part of the
Collateral is made on credit or for future delivery,  the Collateral so sold may
be retained by the Lender until the sale price is paid in full by the  purchaser
or purchasers thereof,  but the Lender shall not incur any liability in case any
such  purchaser or purchasers  shall fail to pay for the Collateral so sold and,
in case of any such failure, such Collateral may be sold again upon like notice.
At any public sale made  pursuant to this Section 6.02 the Lender may bid for or
purchase,  free from any right of  redemption,  stay or appraisal on the part of
the Pledgor  (all of such rights  being also hereby  waived and  released by the
Pledgor),  the  Collateral  or any part  thereof  offered  for sale and may make
payment on account thereof by using any claim then due and payable to the Lender
from the Pledgor as a credit  against the  purchase  price,  and the Lender may,
upon  compliance  with the  terms of sale,  hold,  retain  and  dispose  of such
property without further  accountability to the Pledgor  therefor.  For purposes
hereof,  a written  agreement to purchase the Collateral or any portion  thereof
shall be treated  as a sale  thereof  and the Lender  shall be free to carry out
such sale  pursuant to such  agreement  and the Pledgor shall not be entitled to
the  return  of  the  Collateral  or  any  portion  thereof   subject   thereto,
notwithstanding  the fact that after the Lender  shall have entered into such an
agreement  all Events of Default or Defaults  shall have been  remedied  and the
obligations  paid  in  full.  The  Pledgor  acknowledges  that  compliance  with
applicable federal and state securities laws (including, without limitation, the
Securities Act of 1933, as amended,  Blue Sky or other state  securities laws or
similar laws now or  hereafter  existing  analogous in purpose or effect)  might
strictly  limit or  restrict  the  course of conduct of the Lender if the Lender
were  to  attempt  to  sell  or  otherwise  dispose  of all or any  part  of the
Collateral  which is comprised of  securities,  and might also limit or restrict
the extent to which or the manner in which any subsequent transferee of any such
securities could sell or dispose of the same. Without limiting their generality,
the foregoing  provisions would apply if, for example,  the Lender were to place
all or any part of such securities for private placement by an investment

                                        8

<PAGE>



banking firm, or if such  investment  banking firm  purchased all or any part of
such securities for its own account,  or if the Lender placed all or any part of
such securities privately with a purchaser or purchasers.

     6.03.  Pledgor's  Covenants  in the  Event  of a  Sale  of  Collateral.  In
conjunction  with  any  sale  of all or any  part  of the  Collateral  which  is
comprised  of  securities,  the Pledgor  (i) will,  at any time and from time to
time, upon the request of the Lender,  use his best efforts to take or cause the
issuer of such  securities  to take such action and prepare,  distribute  and/or
file such  documents and papers,  as are required or advisable in the opinion of
the  Lender  and/or his or her  counsel  to permit  the sale of such  securities
whether  at  public  sale,  private  sale or  otherwise;  (ii) will use his best
efforts to qualify,  file or register, or cause the issuer of such securities to
qualify,  file or  register,  any of such  securities  under  federal  and state
securities laws and regulations (including,  without limitation,  the Securities
Act of 1933,  as  amended,  the  rules and  regulations  of the  Securities  and
Exchange  Commission  and  state  Blue Sky or other  securities  laws) as may be
requested by the Lender,  and to keep effective,  or cause to be kept effective,
all  such  qualifications,  filings  or  registrations;  (iii)  agrees  to  hold
harmless,  indemnify and defend the Lender and any underwriter  from and against
all loss, liability,  expenses, costs, fees, disbursements  (including,  without
limitation, the fees and disbursements of the Lender's legal counsel) and claims
which may be incurred insofar as such loss,  liability,  expense or claim arises
out of or is  based  upon  any  alleged  untrue  statement  of a  material  fact
contained in any prospectus  (or any amendment or supplement  thereto) or in any
notification or offering circular, or arises out of or is based upon any alleged
omission to state a material fact required to be stated  therein or necessary to
make the  statements in any thereof not misleading but except to the extent that
any such loss,  liability,  expense or claim may have been  caused by any untrue
statement or omission based upon information furnished in writing to the Pledgor
or the issuer of such securities by the Lender or any underwriter  expressly for
use  therein;  (iv)  will  bear all  costs  and  expenses  of  carrying  out its
obligations under this subsection which shall be a part of the Enforcement Costs
and the  Obligations  secured  hereby;  and (v)  acknowledges  that  there is no
adequate  remedy  at law for the  failure  by the  Pledgor  to  comply  with the
provisions  of this  subsection  and that such failure  would not be  adequately
compensable in damages,  and therefore  agrees that the covenants of the Pledgor
herein contained may be specifically enforced.

     6.04.  Application of Proceeds.  The proceeds of collection,  sale or other
disposition  of  all or  any  part  of the  Collateral  coming  in the  Lender's
possession  may be  applied  by the  Lender to any of the  Obligations,  whether
matured or  unmatured,  in such order and manner as the Lender may  determine in
its sole discretion.

     6.05. No Waiver,  Etc. No failure or delay by the Lender to insist upon the
strict  performance  of any  term,  condition,  covenant  or  agreement  of this
Agreement or of the other Financing  Documents,  or to exercise any right, power
or remedy  consequent  upon a breach thereof,  shall  constitute a waiver of any
such term,  condition,  covenant or agreement or of any such breach, or preclude
the Lender from exercising any such right,  power or remedy at any later time or
times. By accepting  payment after the due date of any amount payable under this
Agreement or under any of the other Financing Documents, the Lender shall not be
deemed to waive the right either to require

                                        9

<PAGE>



prompt  payment when due of all other amounts  payable  under this  Agreement or
under any of the other Financing Documents,  or to declare a Default for failure
to effect  such  prompt  payment of any such other  amount.  The  payment by the
Pledgor or any other and the  acceptance  by the Lender or any other  amount due
and  payable  under the  provisions  of the  Agreement  or the  other  Financing
Documents  at any time  during  which a Default  exists  shall not in any way or
manner be  construed  as a waiver of such  Default by the Lender or preclude the
Lender  from  exercising  any  right of power or  remedy  consequent  upon  such
Default.

                                   ARTICLE VII
                                  MISCELLANEOUS

     7.01. Course of Dealing: Amendment. No course of dealing between the Lender
and the Pledgor  shall be effective to amend,  modify or change any provision of
this Agreement or the other Financing Documents. The Lender shall have the right
at all times to enforce the provisions of this Agreement and the other Financing
Documents  in  strict   accordance  with  the  provisions  hereof  and  thereof,
notwithstanding  any  conduct or custom on the part of the Lender in  refraining
from so doing at any time or times.  The  failure  of the  Lender at any time or
times to enforce its rights under such  provisions  strictly in accordance  with
the same, shall not be construed as having created a custom in any way or manner
contrary  to  specific  provisions  of this  Agreement  or the  other  Financing
Documents  or as having in any way or manner  modified or waived the same.  This
Agreement may not be amended,  modified,  or changed in any respect except by an
agreement, in writing, signed by the Lender and the Pledgor.

     7.02. Waiver of Default. The Lender may, at any time and from time to time,
execute and deliver to the Pledgor a written instrument  waiving,  on such terms
and conditions as the Lender may specify in such written instrument,  any of the
requirements  of this  Agreement  or any Event of  Default  or  Default  and its
consequences;  provided,  however, that any such waiver shall be for such period
and subject to such conditions as shall be specified in any such instrument.  In
the case of any such  waiver,  the Pledgor  and the Lender  shall be restored to
their former  positions prior to such Event or Default or Default and shall have
the same  rights  as they had  hereunder.  No such  waiver  shall  extend to any
subsequent or other Event of Default or Default,  or impair any right consequent
thereto  and  shall  be  effective  only in the  specific  instance  and for the
specific purpose for which given.

     7.03.  Security  Interest  Absolute.  All rights and remedies of the Lender
hereunder and under  applicable  laws, the Security  Interest and all agreements
and  obligations of the Pledgor  hereunder  shall be absolute and  unconditional
irrespective of, and shall not be released, discharged,  impaired or affected by
(a) any lack of validity or  enforceability  of any of the Financing  Documents;
(b) any change in the amount of any or all of the  Obligations  or any change in
the time,  manner or place of  payment of any or all of the  Obligations  or any
change of any other provisions or term of any or all of the Obligations; (c) any
amendment to, or  modification  or waiver of, consent to, or departure from, any
of the provisions of the Financing  Documents;  (d) any exchange,  substitution,
release,  addition or  non-perfection  of any collateral and security for any of
the Obligations; (e) the release of, in whole or in part, any person, including,
without limitation, the Pledgor, obligated or liable for the payment

                                       10

<PAGE>



of all or any part of the  Obligations or any attempt,  pursuit,  enforcement or
exhaustion of any rights or remedies the Lender may have against any such person
or against any  collateral and security for any or all of the  Obligations;  (f)
the failure,  omission,  lack of diligence or delay by the Lender to exercise or
enforce any rights and  remedies it may have under the  Financing  Documents  or
applicable  laws; and (g) any other event or circumstance  which might otherwise
constitute a legal or equitable discharge,  release or defense of the Pledgor or
of the Collateral.

     7.04 Notices. All notices, requests, demands and other communications under
this  Agreement  must be in  writing  and  will be  deemed  duly  given,  unless
otherwise  expressly  indicated  to the  contrary  in this  Agreement,  (i) when
personally delivered,  (ii) upon receipt of a telephonic facsimile  transmission
with a confirmed telephonic transmission answer back, (iii) three (3) days after
having been deposited in the United States mail, certified or registered, return
receipt  requested,  postage prepaid,  or (iv) one (1) business day after having
been dispatched by a nationally recognized overnight courier service,  addressed
to the parties or their permitted assigns at the following addresses (or at such
other  address or number as is given in writing by either party to the other) as
follows:

                           Pledgor:         Allan L. Goldstein
                                            800 25th Street, N.W., Apt. 1005
                                            Washington, D.C. 20037
                                            Fax: (202)

                           Lender:          Alpha 1 Biomedicals, Inc.
                                            3 Bethesda Metro Center
                                            Suite 700
                                            Bethesda, Maryland 20814
                                            Fax: (301) 961-1991

     7.05.  Performance  for Pledgor.  The Pledgor hereby appoints the Lender as
the  attorney-in-fact  of the  Pledgor  for  the  purpose  of  carrying  out the
provisions of this  Agreement and taking any action and executing any instrument
which the Lender may deem  necessary  or advisable  to  accomplish  the purposes
hereof,  which appointment is irrevocable and coupled with an interest.  Without
limiting the generality of the foregoing,  the Lender shall have the right, upon
the  occurrence  and during the  continuance  of an Event of Default,  with full
power of substitution  either in the Lender's name or in the name of the Pledgor
twenty four (24) hours after notice to the Pledgor,  (a) to ask for, demand, sue
for, collect,  receive,  receipt and give acquittance for any and all moneys due
or to become  due and under and by  virtue  of any  Collateral;  (b) to  endorse
checks, drafts, orders and other instruments for the payment of money payable to
the Pledgor representing any interest, dividend or other distribution payable in
respect of the Collateral or any part thereof or on account thereof; (c) to give
full discharge for all or any part of the Collateral; (d) to settle, compromise,
prosecute or defend any action,  claim or proceeding  with respect to all or any
part of the Collateral;  (e) to sell, assign, endorse, pledge, transfer and make
any agreement  respecting  all or any part of the  Collateral;  or (f) otherwise
deal  with all or any part of the  Collateral  as  though  the  Lender  were the
absolute

                                       11

<PAGE>



owner  thereof;  provided,  however,  that  nothing  herein  contained  shall be
construed as requiring or  obligating  the Lender to make any  commitment  or to
make any inquiry as to the nature or sufficiency of any payment  received by the
Lender,  or to present or file any claim or notice,  or to take any action  with
respect to the Collateral or any part thereof or the moneys due or become due in
respect  thereof or any  property  covered  thereby,  and no action taken by the
Lender or omitted to be taken with respect to the Collateral or any part thereof
shall give rise to any defense,  counterclaim  or offset in favor of the Pledgor
or to any claim or action against the Lender.

     7.06. Severability. If any provision hereof is invalid and unenforceable in
any  jurisdiction,  then, to the fullest extent  permitted by law, (a) the other
provisions hereof shall remain in full force and effect in such jurisdiction and
shall be  liberally  construed  in favor of the Lender in order to carry out the
intentions  of  the  parties  hereto  as  nearly  as may be  possible;  (b)  the
invalidity or unenforceability of any provision hereof in any jurisdiction shall
not  affect  the  validity  or  enforceability  of such  provision  in any other
jurisdiction;   and  (c)  the  parties  hereto  shall  endeavor  in  good  faith
negotiations to replace the invalid or  unenforceable  provisions with valid and
enforceable provisions,  the economic effect of which comes as close as possible
to that of the invalid or unenforceable provisions.

     7.07.  Assignment.  The Lender may,  without  notice to, or consent of, the
Pledgor,  sell,  assign or  transfer to any person or persons all or any part of
the Obligations, and in the event of any such assignment, the Security Interests
and rights and  remedies of the Lender  hereunder  shall extend to, and vest in,
any such  assignee  or  assignees  who  shall  have the  right  to  enforce  the
provisions  of this  Agreement as fully as the Lender,  provided that the Lender
shall  continue to have the  unimpaired  right to enforce the provisions of this
Agreement  as to so much of the  Obligations  that it has not sold,  assigned or
transferred. The Pledgor will fully cooperate with the Lender in connection with
any such  assignment and will execute and deliver such consents and  acceptances
to any such  assignment  and amendments to this Agreement in order to effect any
such assignment (including, without limitation, the appointment of the Lender as
agent for itself and all assignees).

     7.08.  Survival.  All  representations,  warranties and covenants contained
among the provisions of this Agreement  shall survive the execution and delivery
of this Agreement and all other Financing Documents.

     7.09. Binding Effect. This Agreement shall be binding upon and inure to the
benefit  of  the   Pledgor  and  the  Lender  and  their   respective   personal
representatives,  successors and assigns, except that the Pledgor shall not have
the right to assign his rights  hereunder  or any  interest  herein  without the
prior written consent of the Lender.

     7.10 Continuing Agreement.  This Agreement and the Security Interests shall
be continuing and binding on the Pledgor  regardless of how long before or after
the date hereof any of the Obligations were or are incurred.  This Agreement and
the Security  Interests shall  terminate when all of the  Obligations  have been
indefeasibly paid in full and no commitments therefor are outstanding.


                                       12

<PAGE>



     7.11.  Applicable Law. This Agreement and the rights and obligations of the
parties hereunder shall be construed and interpreted in accordance with the laws
of the State of Maryland, both in interpretation and performance, without regard
to its choice of law rules.

         7.12.  Heading.  Article and Section  headings  in this  Agreement  are
included herein for  convenience of reference only,  shall not constitute a part
of this  Agreement  for any other  purpose and shall not be deemed to affect the
meaning or construction of any of the provisions hereof.


            (The remainder of this page is intentionally left blank.)

                                       13

<PAGE>


     IN WITNESS WHEREOF,  the parties have executed and delivered this Agreement
under seal as of the day and year first written above.

                                        THE PLEDGOR:



                                        /s/ Allan L. Goldstein            (SEAL)
                                        ---------------------------------------
                                        Allan L. Goldstein



                                        THE LENDER:

                                        Alpha 1 Biomedicals, Inc.



                                        By: Albert Rosenfeld
                                            -----------------------------------
                                           Albert Rosenfeld,
                                           Secretary-Treasurer



                           )
District of Columbia       )        ss:
                           )

     I HEREBY CERTIFY that on this 18th day of February,  2000,  before me, the
subscriber,  a Notary Public in and for
 the jurisdiction  aforesaid,  personally
appeared ALLAN L. GOLDSTEIN who is known (or satisfactorily  proven) to me to be
the person whose name is subscribed to the foregoing instrument and acknowledged
that he freely and voluntarily executed the same for the purposes therein.

         WITNESS my hand and notarial seal.

                                                      /s/ Noemi C. Taylor
                                                  ------------------------------
                                                         NOTARY PUBLIC

                         Noemi C. Taylor
                         Notary Public District Columbia
My Commission Expires:   12/14/2004


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