ALPHA 1 BIOMEDICALS INC
DEF 14A, 2000-11-08
PHARMACEUTICAL PREPARATIONS
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                                SCHEDULE 14A

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

 Filed by the Registrant /X/

 Filed by a Party other than the Registrant / /

 Check the appropriate box:

/ / Preliminary Proxy Statement

/ / Confidential,for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
/X/ Definitive Proxy Statement
/ / Definitive Additional Materials
/ / Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12

                            ALPHA 1 BIOMEDICALS, INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

/X/ No fee required.

/ / Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

     (2)  Aggregate number of securities to which transaction applies:

     (3)  Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined)

     (4)  Proposed maximum aggregate value of transaction:

     (5)  Total fee paid:

/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as  provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

         (1)      Amount Previously Paid:
         (2)      Form, Schedule or Registration Statement No.:
         (3)      Filing Party:
         (4)      Date Filed:

<PAGE>

                                November 8, 2000



Dear Fellow Stockholder:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of Alpha 1 Biomedicals,  Inc., to be held at 10:00 a.m.,  local time, on Friday,
December 15, 2000,  at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin
Avenue, Bethesda, Maryland 20814.

         An important  aspect of the annual meeting  process is the  stockholder
vote on  corporate  business  items.  I urge you to  exercise  your  rights as a
stockholder  to vote and  participate  in this process.  Stockholders  are being
asked to  consider  and vote upon (i) the  election  of three  directors  of the
Company; (ii) a proposed amendment to the Company's certificate of incorporation
to change the  Company's  name from  "Alpha 1  Biomedicals,  Inc." to  "RegeneRx
Biopharmaceuticals,   Inc.";   (iii)  a  proposed  amendment  to  the  Company's
certificate  of  incorporation  to increase the number of shares of common stock
authorized  for issuance from  20,000,000 to  100,000,000;  (iv) approval of the
Company's 2000 Stock Option and Incentive Plan; and (v) the  ratification of the
appointment  of Reznick  Fedder & Silverman,  P.C. as the Company's  independent
auditors.

         I  encourage  you to attend the  meeting in person.  Whether or not you
plan to attend,  however, please read the enclosed proxy statement and vote your
shares as promptly as possible. This will save the Company additional expense in
soliciting  proxies  and will ensure  that your  shares are  represented  at the
meeting.

         Your Board of Directors and  management are committed to the success of
the  Company  and the  enhancement  of the  value  of your  investment.  As your
Chairman and President,  I want to express my  appreciation  for your confidence
and support.

                                 Very truly yours,




                                 Allan L. Goldstein, Ph.D.
                                 Chairman, President and Chief
                                  Executive Officer



<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 961-1992

                   ------------------------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                          TO BE HELD DECEMBER 15, 2000
                   ------------------------------------------

         NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Alpha
1 Biomedicals, Inc. will be held as follows:
<TABLE>
<S>                      <C>         <C>        <C>
TIME................... 10:00 a.m. local time
DATE................... Friday, December 15, 2000
PLACE.................. Hyatt Regency Bethesda, 7400 Wisconsin Avenue, Bethesda,
                        Maryland 20814
ITEMS OF BUSINESS.......             (1)    To elect three directors, each for a
                                            term expiring at next year's annual
                                            meeting of stockholders.

                                     (2)      To approve a  proposed  amendment
                                               to the Company's  certificate  of
                                               incorporation   to   change   the
                                               Company's   name  from  "Alpha  1
                                               Biomedicals, Inc." to "RegeneRx
                                               Biopharmaceuticals, Inc."

                                      (3)      To approve a  proposed  amendment
                                               to the Company's  certificate  of
                                               incorporation   to  increase  the
                                               number of shares of common  stock
                                               authorized   for  issuance   from
                                               20,000,000 to 100,000,000.

                                      (4)      To  approve  the  Company's  2000
                                               Stock Option and Incentive Plan.

                                      (5)      To  ratify  the   appointment  of
                                               Reznick Fedder & Silverman,  P.C.
                                               as  the   Company's   independent
                                               auditors   for  the  fiscal  year
                                               ending December 31, 2000.

                                      (6)      To  transact  any other  business
                                               that may properly come before the
                                               meeting  and any  adjournment  or
                                               postponement of the meeting.

RECORD DATE.............Holders of record of the Company's common stock at the close of
                        business on October 23, 2000 will be entitled to vote at the meeting
                        or any adjournment of the meeting.

ANNUAL REPORT...........The Company's Annual Report on Form 10-KSB for the year ended
                        December 31, 1999 is enclosed.

PROXY VOTING............It is important that your shares be represented and voted at the
                        meeting.  You can vote your shares by returning the enclosed proxy
                        card in the enclosed envelope.  Regardless of the number of
                        shares you own, your vote is very important.  Please act today.
</TABLE>


                                          BY ORDER OF THE BOARD OF DIRECTORS



                                          ALLAN L. GOLDSTEIN
                                          Chairman of the Board

Bethesda, Maryland
November 8, 2000


<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 961-1992

                  --------------------------------------------
                                 PROXY STATEMENT
                  --------------------------------------------


                         ANNUAL MEETING OF STOCKHOLDERS
                                DECEMBER 15, 2000


                                TABLE OF CONTENTS

                                                                           PAGE
INTRODUCTION.................................................................1

INFORMATION ABOUT THE ANNUAL MEETING.........................................1
    What is the purpose of the annual meeting?...............................1
    Who is entitled to vote?.................................................2
    What if my shares are held in "street name" by a broker?.................2
    How many shares must be present to hold the annual meeting?..............2
    What if a quorum is not present at the annual meeting?...................2
    How do I vote?...........................................................2
    Can I change my vote after I submit my proxy?............................3
    How does the Board of Directors recommend I vote on the proposals?.......3
    What if I do not specify how my shares are to be voted?..................3
    Will any other business be conducted at the annual meeting?..............3
    How many votes are required to elect the director nominees?..............3
    What happens if a nominee is unable to stand for election?...............4
    How many votes are required to approve the other proposals?..............4
    How will abstentions be treated?.........................................4
    How will broker non-votes be treated?....................................4

STOCK OWNERSHIP..............................................................4
    Stock Ownership of Significant Stockholders, Directors and
      Executive Officers.....................................................4
    Section 16(a) Beneficial Ownership Reporting Compliance..................6

PROPOSAL 1 - ELECTION OF DIRECTORS...........................................6
    Board of Directors' Meetings and Committees..............................7
    Directors' Compensation..................................................7
    Summary Compensation Table...............................................8
    Certain Transactions.....................................................9

PROPOSAL 2 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
    TO CHANGE THE COMPANY'S NAME............................................10

PROPOSAL 3 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
    TO INCREASE THE AUTHORIZED SHARES OF COMMON STOCK.......................10

PROPOSAL 4 - APPROVAL OF THE 2000 STOCK OPTION AND INCENTIVE PLAN...........12


                                        i

<PAGE>



PROPOSAL 5 - RATIFICATION OF APPOINTMENT OF AUDITORS........................15

OTHER MATTERS...............................................................16

ADDITIONAL INFORMATION......................................................16
         Proxy Solicitation Costs...........................................16
         Stockholder Proposals for 2001 Annual Meeting......................16






                                       ii

<PAGE>



                            ALPHA 1 BIOMEDICALS, INC.
                       3 Bethesda Metro Center, Suite 700
                            Bethesda, Maryland 20814
                                 (301) 961-1992


                  --------------------------------------------

                                 PROXY STATEMENT

                  --------------------------------------------



                                  INTRODUCTION

         The Board of Directors of Alpha 1 Biomedicals,  Inc. (the "Company") is
using this proxy  statement to solicit proxies from the holders of the Company's
common stock for use at the Company's  upcoming Annual Meeting of  Stockholders.
The annual meeting will be held on December 15, 2000 at 10:00 a.m.,  local time,
at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin  Avenue,  Bethesda,
Maryland  20814. At the annual  meeting,  stockholders  will be asked to vote on
five  proposals:  (1) the election of three  directors  of the Company,  each to
serve for a term expiring at next year's annual meeting of stockholders; (2) the
approval of a proposed  amendment to the Company's  certificate of incorporation
to change the  Company's  name from  "Alpha 1  Biomedicals,  Inc." to  "RegeneRx
Biopharmaceuticals,  Inc.";  (3) the  approval  of a proposed  amendment  to the
Company's  certificate  of  incorporation  to  increase  the number of shares of
common stock  authorized for issuance from  20,000,000 to  100,000,000;  (4) the
approval of the  Company's  2000 Stock Option and  Incentive  Plan;  and (5) the
ratification  of the  appointment  of Reznick  Fedder &  Silverman,  P.C. as the
Company's  independent  auditors  for the fiscal year ending  December 31, 2000.
These  proposals  are  described in more detail  below.  Stockholders  also will
consider any other  matters that may  properly  come before the annual  meeting,
although the Board of Directors knows of no other business to be presented.

         By  submitting  your  proxy,  you  authorize  the  Company's  Board  of
Directors  to  represent  you and vote your  shares  at the  annual  meeting  in
accordance  with  your  instructions.  The Board  also may vote  your  shares to
adjourn the annual meeting from time to time and will be authorized to vote your
shares at any adjournments or postponements of the annual meeting.

         The Company's  Annual Report on Form 10-KSB for the year ended December
31, 1999, filed by the Company with the Securities and Exchange  Commission,  is
enclosed. The Quarterly Reports on Form 10-QSB filed by the Company with the SEC
are available on the SEC's website,  at  "www.sec.gov."  Neither the Form 10-KSB
nor any of the  Company's  quarterly  reports or other SEC filings  constitute a
part  of the  proxy  solicitation  materials  and  none  of  these  filings  are
incorporated into this proxy statement by reference.

         This proxy statement and the accompanying materials are being mailed to
stockholders on or about November 8, 2000.

         Your vote is  important.  Whether  or not you plan to attend the annual
meeting, please vote promptly.


                      INFORMATION ABOUT THE ANNUAL MEETING

What is the purpose of the annual meeting?

         At the  annual  meeting,  stockholders  will  be  asked  to vote on the
following proposals:

         Proposal 1.       Election of three  directors of the Company,  each
                           for a term expiring at next year's annual  meeting of
                           stockholders;

         Proposal 2.       Approval of a proposed  amendment to the Company's
                           certificate of  incorporation to change the Company's
                           name from "Alpha 1  Biomedicals,  Inc." to  "RegeneRx
                           Biopharmaceuticals, Inc.;"


                                        1

<PAGE>



         Proposal 3.       Approval of a proposed  amendment to the Company's
                           certificate of  incorporation  to increase the number
                           of shares of common  stock  authorized  for  issuance
                           from 20,000,000 to 100,000,000;

         Proposal 4.       Approval of the  Company's  2000 Stock Option and
                           Incentive Plan; and

         Proposal 5.       Ratification of the appointment of Reznick Fedder
                           &  Silverman,   P.C.  as  the  Company's  independent
                           auditors  for the fiscal  year  ending  December  31,
                           2000.

Stockholders  also will act on any other  business that may properly come before
the  annual  meeting.  Members  of our  management  team will be  present at the
meeting to respond to your questions.

Who is entitled to vote?

         The record date for the meeting is October 23, 2000. Only  stockholders
of record at the close of business on that date are entitled to notice of and to
vote at the annual meeting.  The only class of stock entitled to be voted at the
annual meeting is the Company's common stock.  Each outstanding  share of common
stock is entitled to one vote for all matters before the annual meeting.  At the
close of business on the record  date,  there were  19,477,429  shares of common
stock outstanding.

What if my shares are held in "street name" by a broker?

         If your  shares are held in "street  name" by a broker,  your broker is
required to vote your shares in accordance with your instructions. If you do not
give  instructions to your broker,  your broker will nevertheless be entitled to
vote  your  shares  with  respect  to  "discretionary"  items,  but  will not be
permitted to vote your shares with respect to "non-discretionary"  items. In the
case of  non-discretionary  items,  your  shares  will  be  treated  as  "broker
non-votes." Proposal 4 is expected to be considered a "non-discretionary"  item.
All other proposals are expected to be considered "discretionary items."

How many shares must be present to hold the annual meeting?

         A quorum must be present at the annual  meeting for any  business to be
conducted.  The presence at the annual  meeting,  in person or by proxy,  of the
holders of a majority of the shares of common  stock  outstanding  on the record
date will  constitute a quorum.  Proxies  received but marked as  abstentions or
broker  non-votes  will be included in the  calculation  of the number of shares
considered to be present at the annual meeting.

What if a quorum is not present at the annual meeting?

         If a quorum is not present at the scheduled time of the annual meeting,
the  stockholders  who are  represented  may adjourn the annual  meeting until a
quorum is present. The time and place of the adjourned meeting will be announced
at the time the adjournment is taken. An adjournment  will have no effect on the
business that may be conducted at the annual meeting.

How do I vote?

         1.  YOU MAY  VOTE BY  PROXY.  If you  properly  complete  and  sign the
accompanying proxy card and return it in the enclosed envelope, it will be voted
in accordance with your  instructions.  If your shares are held in "street name"
with a bank,  broker or some other third  party,  you also may be able to submit
your proxy vote by telephone or via the  internet.  Check your proxy card to see
if voting by telephone and/or the internet is available to you.

         2. YOU MAY VOTE IN PERSON AT THE ANNUAL MEETING.  If you plan to attend
the annual meeting and wish to vote in person,  we will give you a ballot at the
annual  meeting.  Note,  however,  that if your shares are held in "street name"
with a bank,  broker or some other third party,  you will need to obtain a proxy
from the record holder of your shares  indicating  that you were the  beneficial
owner of those shares on October 23, 2000, the record date for voting at

                                        2

<PAGE>



the annual  meeting.  You are  encouraged  to vote by proxy  prior to the annual
meeting even if you plan to attend the annual meeting.

Can I change my vote after I submit my proxy?

         Yes,  you may revoke your proxy and change your vote at any time before
the polls close at the annual meeting by:

       o  submitting another proxy with a later date;
       o  giving written notice of the revocation of your proxy to the Company's
          Secretary prior to the annual meeting; or
       o  voting  in  person  at the  annual  meeting.  Your  proxy  will not be
          automatically  revoked by your mere  attendance at the annual meeting;
          you must actually vote at the annual meeting to revoke a prior proxy.

How does the Board of Directors recommend I vote on the proposals?

        Your Board recommends that you vote:

       o  FOR election of the three  nominees  named in this proxy  statement to
          the Board of Directors;
       o  FOR approval of the proposed amendment to the Company's certificate of
          incorporation  to change the Company's name from "Alpha 1 Biomedicals,
          Inc." to "RegeneRx Biopharmaceuticals, Inc.";
       o  FOR approval of the proposed amendment to the Company's certificate of
          incorporation  to  increase  the  number of  shares  of  common  stock
          authorized for issuance from 20,000,000 to 100,000,000;
       o  FOR approval of the Company's  2000 Stock Option and  Incentive  Plan;
          and
       o  FOR  ratification  of the  appointment  of Reznick Fedder & Silverman,
          P.C. as the Company's  independent auditors for the fiscal year ending
          December 31, 2000.

What if I do not specify how my shares are to be voted?

        If you are a stockholder  of record and you submit an executed proxy but
do not indicate any voting instructions, your shares will be voted:

       o  FOR election of the three  nominees  named in this proxy  statement to
          the Board of Directors; and
       o  FOR each of the other proposals.

        If your shares are held in "street name" with a broker,  your broker may
vote your shares in its discretion with respect to "discretionary" items. In the
case of "non-discretionary" items, your shares will not be voted.

Will any other business be conducted at the annual meeting?

         The  Board  of  Directors  knows  of no  other  business  that  will be
presented at the annual meeting.  If, however, any other proposal properly comes
before  the  stockholders  for a vote  at  the  annual  meeting,  the  Board  of
Directors, as holder of your proxy, will vote your shares in accordance with its
best judgment.

How many votes are required to elect the director nominees?

         The  affirmative  vote of a  plurality  of the votes cast at the annual
meeting  by the  holders  of shares  present in person or by proxy at the annual
meeting and  entitled to vote is required to elect the three  nominees  named in
this proxy  statement as directors.  This means that the three  nominees will be
elected if they receive more affirmative  votes than any other persons nominated
for election.  No persons have been  nominated for election other than the three
nominees named in this proxy  statement.  If you vote "Withheld" with respect to
the election of one or more nominees, your shares will not be voted with respect
to the person or persons  indicated,  although  such  shares will be counted for
purposes of determining whether there is a quorum.



                                        3

<PAGE>



What happens if a nominee is unable to stand for election?

         If a nominee is unable to stand for  election,  the Board of  Directors
may either  reduce the number of  directors  to be elected  (if the Board  first
amends the  Company's  Bylaws to permit the  reduction)  or select a  substitute
nominee. If a substitute nominee is selected, the Board of Directors,  as holder
of your proxy, will vote your shares for the substitute  nominee unless you have
withheld authority to vote for the nominee replaced.

How many votes are required to approve the other proposals?

         The proposals to amend the Company's  certificate of  incorporation  to
change the  Company's  name and to increase the number of shares of common stock
authorized  for  issuance  must each be  approved by the  affirmative  vote of a
majority of the outstanding  shares of common stock.  Approval of the 2000 Stock
Option and Incentive Plan and the  ratification  of the  appointment of auditors
each require the affirmative vote of a majority of the votes cast by the holders
of shares  present at the annual  meeting in person or by proxy and  entitled to
vote on the matter.  Approval  of the 2000 Stock  Option and  Incentive  Plan is
conditioned  upon  approval of the proposal to increase the number of authorized
shares.  Therefore,  if the proposal to increase the number of authorized shares
is not  approved,  then the  proposal  to  approve  the 2000  Stock  Option  and
Incentive  Plan will be deemed not to have been  approved.  This is because  the
remaining number of shares of common stock currently  authorized for issuance is
not sufficient to allow for the grant of options under the 2000 Stock Option and
Incentive Plan.

How will abstentions be treated?

         If you abstain  from  voting,  your  shares will still be included  for
purposes of determining  whether a quorum is present.  Because directors will be
elected by a  plurality  of the votes cast by the  holders of shares  present in
person or by proxy at the annual meeting,  abstaining is not offered as a voting
option for  Proposal 1. If you abstain from voting on any other  proposal,  your
shares  will be  included in the number of shares  voting on the  proposal  and,
consequently,  your  abstention  will  have the  effect  of a vote  against  the
proposal.

How will broker non-votes be treated?

         Shares  treated as broker  non-votes on one or more  proposals  will be
included  for purposes of  calculating  the presence of a quorum but will not be
counted  as votes  cast or treated  as shares  entitled  to vote.  Consequently,
broker  non-votes will have the effect of votes against  Proposals 2 and 3 (name
change  and  authorized  shares  increase)  and no  effect  on any of the  other
proposals.

                                 STOCK OWNERSHIP

Stock Ownership of Significant Stockholders, Directors and Executive Officers

         The  following  table  shows,  as of October 23, 2000,  the  beneficial
ownership of the Company's common stock by:

       o  any persons or entities known by management to  beneficially  own more
          than five percent of the outstanding shares of Company common stock;

       o  each director of the Company; and

       o  all of the executive officers and directors of the Company as a group.


                                        4

<PAGE>



         The  persons  named  in  the  following  table  have  sole  voting  and
dispositive powers for all shares of common stock shown as beneficially owned by
them,  subject  to  community  property  laws  where  applicable  and  except as
indicated in the footnotes to the table.

         Beneficial  ownership is determined in accordance with the rules of the
Securities  and  Exchange   Commission.   Shares  of  common  stock  subject  to
outstanding  options,  warrants or other rights to acquire held by a person that
are currently  exercisable or exercisable  within 60 days after October 23, 2000
are included in the number of shares beneficially owned by the person and deemed
outstanding   shares  for  purposes  of  calculating  the  person's   percentage
ownership.  These shares are not, however, deemed outstanding for the purpose of
computing the percentage  ownership of any other person. As of October 23, 2000,
there were 19,477,429 shares of Company common stock outstanding.
<TABLE>

                                                                                                       Percent of
                                                                                      Beneficial      Common Stock
                    Name of Beneficial Owner                                           Ownership       Outstanding
-----------------------------------------------------------------        -----------------------   -------------------
<S>                                                                                       <C>               <C>
Roger H. Samet                                                                         997,050(1)         5.04%
J. J. Finkelstein                                                                    1,875,000(2)         9.63
Richard J. Hindin                                                                    1,885,000(3)         9.68
Sidney J. Silver                                                                     1,875,000(4)         9.63
Allan L. Goldstein, Chairman, President and Chief                                    2,342,491(5)        12.03
  Executive Officer
Michael L. Berman,                                                                      89,450(6)         0.46
  Former Chief Executive Officer
Joseph C. McNay, Director                                                              792,000(7)         4.03
Albert Rosenfeld, Director, Secretary and Treasurer                                     25,100(8)         0.13
All executive officers and directors as a group (3 persons)                          3,159,591(9)        16.06
</TABLE>

----------
(1)  As reported by Mr. Samet on Amendment  No. One to a Schedule 13D filed with
     the  SEC  on  February  24,  1999.  Mr.  Samet  reported  sole  voting  and
     dispositive  powers as to all  shares  listed.  Included  among the  shares
     listed are 292,050 shares which Mr. Samet has the right to acquire pursuant
     to Class D warrants  issued to him by the Company.  Mr. Samet's  address is
     254 East 68th Street, #29B, New York, NY 10021.

(2)  As  reported  by Mr.  Finkelstein  on a Schedule  13D filed with the SEC on
     November  7,  2000.  The  address  for  Mr.  Finkelstein  is  c/o  Alpha  1
     Biomedicals,  Inc., 3 Bethesda Metro Center, Suite 700, Bethesda,  Maryland
     20814.

(3)   As reported by Mr. Hindin on a Schedule 13D filed with the SEC on November
      7, 2000.  The address for Mr.  Hindin is 407 Chain  Bridge  Road,  McLean,
      Virginia 22101.

(4)  As reported by Mr.  Silver on a Schedule 13D filed with the SEC on November
     7, 2000. The address for Mr. Silver is c/o Silver, Freedman & Taff, L.L.P.,
     1100 New York Avenue, N.W., Washington, D.C. 20005.

(5)  As  reported  by Dr.  Goldstein  on a  Schedule  13D filed  with the SEC on
     November 7, 2000.  Consists of (i) 2,249,285  shares owned  directly by Dr.
     Goldstein over which he has sole voting and  dispositive  powers;  and (ii)
     93,206  shares  held by Dr.  Goldstein's  wife  with  respect  to which Dr.
     Goldstein  shares  voting  and  dispositive  powers.  The  address  for Dr.
     Goldstein is c/o Alpha 1 Biomedicals,  Inc., 3 Bethesda Metro Center, Suite
     700, Bethesda, Maryland 20814.

(6)  Consists of (i) 68,000  shares  directly  owned by Dr. Berman over which he
     has sole voting and  dispositive  powers;  and (ii) 21,450 shares which Dr.
     Berman  has the  right  to  acquire  pursuant  to the  exercise  of Class D
     warrants.  The address for Dr. Berman is c/o Alpha 1  Biomedicals,  Inc., 3
     Bethesda Metro Center, Suite 700, Bethesda, Maryland 20814.

(7)  Consists of (i) 612,000  shares  owned  directly by Mr. McNay over which he
     has sole voting and dispositive  powers; (ii) 15,000 shares which Mr. McNay
     has the right to acquire  through the  exercise of stock  options  that are
     currently  exercisable;  and (iii)  165,000  shares which Mr. McNay has the
     right to acquire pursuant to the exercise of Class D warrants.  The address
     for Mr. McNay is c/o Alpha 1  Biomedicals,  Inc., 3 Bethesda  Metro Center,
     Suite 700, Bethesda, Maryland 20814.

                                        5

<PAGE>



(8)  Consists of (i) 10,100 shares owned directly by Mr. Rosenfeld over which he
     has sole voting and  dispositive  powers;  and (ii) 15,000 shares which Mr.
     Rosenfeld  has the right to acquire  through the exercise of stock  options
     that are currently exercisable.  The address for Mr. Rosenfeld is c/o Alpha
     1 Biomedicals, Inc., 3 Bethesda Metro Center, Suite 700, Bethesda, Maryland
     20814.

(9)  Consists  of (i)  2,871,385  shares  owned  directly by all  directors  and
     executive  officers of the Company as a group; (ii) 30,000 shares which all
     directors  and  executive  officers  as a group  have the right to  acquire
     through the exercise of stock options that are currently exercisable; (iii)
     93,206  shares  owned by family  members  of all  directors  and  executive
     officers  as a group;  and (iv)  165,000  shares  which all  directors  and
     executive  officers  as a group have the right to acquire  pursuant  to the
     exercise of Class D warrants.  Does not include  shares held by Dr. Berman,
     the Company's former Chief Executive Officer.


Section 16(a) Beneficial Ownership Reporting Compliance

         Section  16(a) of the  Securities  Exchange  Act of 1934,  as  amended,
requires the Company's  directors and  executive  officers,  and persons who own
more than 10% of the Company's  common stock, to report to the SEC their initial
ownership  of the  Company's  common  stock and any  subsequent  changes in that
ownership. Specific due dates for these reports have been established by the SEC
and the Company is required to disclose in this proxy statement any late filings
or failures to file.

         To the Company's knowledge, based solely on its review of the copies of
such reports furnished to the Company and written  representations that no other
reports  were  required  during the fiscal year ended  December  31,  1999,  all
Section 16(a) filing requirements applicable to the Company's executive officers
and directors during 1999 were met except for the inadvertent  failure to report
on Form 5 one transaction by Dr. Goldstein.

                       PROPOSAL 1 - ELECTION OF DIRECTORS

         The Company's Board of Directors consists of three directors. Directors
are elected annually to serve one-year terms.

         The  three  individuals  listed  below  each have  been  nominated  for
election as a director  at the annual  meeting,  to hold  office  until the next
annual meeting of stockholders and until his successor is elected and qualified.
Each nominee has consented to being named in this proxy statement and has agreed
to serve if elected. If a nominee is unable to stand for election,  the Board of
Directors  may either  reduce the number of directors to be elected (if it first
amends the  Company's  Bylaws to permit the  reduction)  or select a  substitute
nominee. If a substitute nominee is selected, the Board of Directors,  as holder
of your proxy, will vote your shares for the substitute nominee, unless you have
withheld authority to vote for the nominee replaced.

         The  affirmative  vote of a  plurality  of the votes cast at the annual
meeting  by the  holders  of shares  present in person or by proxy at the annual
meeting is required to elect the nominees  named below as directors.  Your Board
of  Directors  recommends  that  you  vote  "FOR"  the  election  of each of the
nominees.

         The following table sets forth, with respect to each nominee,  his name
and age, the year in which he first  became a director of the  Company,  and his
principal occupation and business experience during the past five years.

<TABLE>

         Nominee, Year First                                Principal Occupation and
     Became Director of Company       Age                      Business Experience
-------------------------------------------------------------------------------------------------------------
<S>                                    <C>   <C>
Allan L. Goldstein, 1982               63    Chairman of the Board of the Company since 1982; Chief Executive
                                             Officer of the Company from 1982 to 1986, and 1999 to present; Chief
                                             Scientific Advisor of the Company from 1982 to present; Professor
                                             and Chairman of Department of Biochemistry and Molecular Biology
                                             at The George Washington University School of Medicine and Health
                                             Sciences from 1978 to present.

</TABLE>

                                        6

<PAGE>

<TABLE>
        Nominee, Year First                                Principal Occupation and
     Became Director of Company       Age                      Business Experience
-------------------------------------------------------------------------------------------------------------
<S>                                    <C>   <C>

Joseph C. McNay, 1987                  66    Chairman and Director of Essex Investment Management Company,
                                             Inc., a registered investment advisor, from 1976 to present; Director of
                                             Softech, Inc. and MPSI System, Inc.
Albert Rosenfeld, 1982                 79    Secretary - Treasurer of the Company from 1999 to present;
                                             Consultant on Future Programs for March of Dimes Birth Defect
                                             Foundation from 1973 to present; Adjunct Professor, Department of
                                             Human Biological Chemistry and Genetics at University of Texas
                                             Medical Branch, from 1974 to 1998; frequent author and lecturer on
                                             scientific matters.
</TABLE>


Board of Directors' Meetings and Committees

         The Company's Board of Directors met once in fiscal 1999. Each director
attended this meeting.  During fiscal 1999, no director of the Company  attended
fewer than 75% of the  aggregate of the total  number of Board  meetings and the
total  number of meetings  held by the  committees  of the Board of Directors on
which he served.  The Board of  Directors  of the  Company has  standing  Audit,
Compensation and Stock Option committees.

         The Audit  Committee  seeks to ensure  that  appropriate  audits of the
Company are conducted. In carrying out this responsibility,  the Audit Committee
meets regularly with management and representatives of the Company's independent
auditors and reviews the scope of internal and external audit activities and the
results of the annual audit. The independent  auditors have direct access to the
Audit Committee to discuss the results of their examination, the adequacy of the
internal  accounting  controls and the  integrity of  financial  reporting.  The
members of the Audit  Committee are  Directors  McNay and  Rosenfeld.  The Audit
Committee did not meet during fiscal 1999.

         The  Compensation  Committee is responsible  for the  determination  of
compensation  paid  to  executive  officers.  The  members  of the  Compensation
Committee are Directors McNay and Rosenfeld.  The Compensation Committee did not
meet in fiscal 1999.

         The  Stock  Option  Committee  is  responsible  for  administering  the
Company's stock option plans and in this capacity  approves stock option grants.
Each  director  is a member  of the Stock  Option  Committee.  The Stock  Option
Committee did not meet in fiscal 1999.

         The entire Board of  Directors  of the Company  acts as the  Nominating
Committee  for  selecting  nominees  for election to the Board.  The  Nominating
Committee  generally  meets  once  per  year  to  make  nominations.  While  the
Nominating  Committee will consider  nominees  recommended by stockholders,  the
Nominating  Committee has not actively  solicited such nominations.  Pursuant to
the Company's  bylaws,  nominations for election as directors by stockholders at
an  annual  meeting  must be made in  writing  and  delivered  to the  Company's
Secretary  not less than 14 days nor more than 120 days prior to the date of the
meeting.  If, however,  notice of the meeting is given to stockholders less than
21 days prior to the meeting,  the nominations  must be received by the close of
business on the seventh day following the day on which notice of the meeting was
mailed to stockholders.

Directors' Compensation

         Prior to the Company's  suspension of operations in 1998,  non-employee
directors (Directors McNay and Rosenfeld) were each paid an annual fee of $5,000
and a fee of $1,250 for each meeting attended in person, and were reimbursed for
expenses   incurred  in  attending  Board  meetings.   Upon  the  suspension  of
operations,  the Company discontinued paying director fees. It is uncertain when
the Company will  reinstitute  the payment of director  fees.  Each of Directors
McNay and Rosenfeld  are owed  director  fees earned prior to the  suspension of
operations amounting to $13,916. It is uncertain when these amounts will be paid
and whether these amounts will be paid with interest.


                                        7

<PAGE>



Summary Compensation Table

         The following table summarizes for the years indicated the compensation
paid by the Company to each person who served as the Company's  Chief  Executive
Officer during 1999. No other  executive  officer of the Company earned a salary
and bonus for 1999 in excess of $100,000.
<TABLE>

                                                                                                      Long Term
                                                              Annual Compensation                 Compensation Awards
                                                     -----------------------------------       -------------------------------------
                                                                                Other        Restricted
                                                                               Annual          Stock                      All Other
                                        Fiscal                              Compensation        Award        Options       Compen-
     Name and Principal Position         Year       Salary       Bonus         ($)(2)            ($)           (#)         sation
     ---------------------------         ----       ------       -----         ------            ---           ---         ------
<S>                                      <C>         <C>           <C>         <C>               <C>           <C>           <C>
Allan L. Goldstein, President and        1999         ---          ---          ---              ---        1,875,000        ---
Chief Executive Officer(1)               1998         ---          ---          ---              ---              ---        ---
                                         1997         ---          ---          ---              ---          455,121        ---
Michael L. Berman                        1999   $  22,816          ---          ---              ---              ---        ---
Former Chief Executive Officer           1998     104,617          ---          ---              ---              ---        ---
                                         1997     149,820          ---          ---              ---          682,682     $2,960
</TABLE>
-----------------

(1)  Dr. Goldstein was appointed Chief Executive Officer upon the resignation of
     Dr. Berman in July 1999.
(2)  Neither  Dr.  Goldstein  nor  Dr.  Berman  received  personal  benefits  or
     perquisites  which  exceeded the lesser of $50,000 or 10% of his salary and
     bonus.

         The following table sets forth certain information concerning grants of
stock options to Drs. Goldstein and Berman during fiscal 1999.
<TABLE>

                                 OPTION GRANTS IN LAST FISCAL YEAR
                            =====================================================================
                                                    Individual Grants
                            =====================================================================
                             Number of          % of Total
                              Shares             Options
                            Underlying          Granted to         Per Share
                              Options          Employees in        Exercise          Expiration
                              Granted          Fiscal Year           Price              Date
==================================================================================================
<S>                           <C>                 <C>                <C>               <C>
Allan L. Goldstein            1,875,000          100%               $0.04             08/15/09
Michael L. Berman                   ---          ---                  ---                ---
======================  =================== ================== ================= ==================
</TABLE>


                                        8

<PAGE>



         The following  table provides  information as to the value of the stock
options held by Drs. Goldstein and Berman as of December 31, 1999 and the values
realized by them upon the exercise of stock options during fiscal 1999.
<TABLE>

                              AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FY-END
                                                    OPTION VALUES
                              ========================================================================================
                                                               Number of
                                                              Securities                        Value of
                                                               Underlying                      Unexercised
                                                              Unexercised                     In-the-Money
                                                              Options at                       Options at
                                                              FY-End (#)                       FY-End ($)
                             Shares                  =================================================================
         Name               Acquired       Value
                          on Exercise     Realized   Exercisable    Unexercisable    Exercisable      Unexercisable
                              (#)           ($)          (#)             (#)             ($)               ($)
=======================================================================================================================
<S>                           <C>           <C>         <C>              <C>            <C>                <C>
Allan L. Goldstein            ---           $---      1,875,000          ---           $---(1)             $---
Michael L. Berman             ---            ---         ---             ---            ---                 ---
=======================================================================================================================
</TABLE>

(1) An option is  in-the-money  if the exercise price of the option is less than
    the market value of the stock underlying the option. None of Dr. Goldstein's
    options were in-the-money as of December 31, 1999.


Certain Transactions

         Loan to Dr. Goldstein.  In May 1994, the Company extended a loan in the
amount of $149,000 to Dr. Goldstein for the purpose of enabling Dr. Goldstein to
meet a margin call on a brokerage account collateralized by Company common stock
at a time when the Board of Directors concluded that it would be contrary to the
best interests of the Company for Dr. Goldstein to sell the shares. The loan was
unsecured and had an interest  rate equal to the prime rate,  with all principal
and interest due on the December 31, 1994 maturity  date. The loan was repaid on
January 1, 1995,  in part with the  proceeds of a second  loan to Dr.  Goldstein
from the Company in the amount of $115,617 that was  unsecured.  The second loan
has an  interest  rate  of  11.5%  and  was to be  repaid  in 36  equal  monthly
installments.

         In February  1996, the terms of the second loan were amended to provide
for the  suspension  of  installment  payments for 12 months,  but with interest
continuing  to accrue.  In March 1997 and December  1997,  the terms of the loan
were further  amended to suspend  installment  payments an  additional  nine and
twelve months,  respectively,  with interest  continuing to accrue.  The Company
suspended  operations  in  1998  and  principal  and  interest  payments  by Dr.
Goldstein  ceased during and subsequent to the  suspension of operations.  As of
December 31, 1999, the balance owed by Dr. Goldstein was $69,674, which has been
fully  reserved  by the  Company as a  doubtful  collection.  In July 2000,  the
Company  agreed  to waive all prior and  subsequent  interest  during  and after
suspension  of the  Company's  operations  and  approved a payment  plan for the
$69,674 owed by Dr. Goldstein to the Company in 36 equal monthly installments of
$1,935.38.  In August 2000, the Company agreed to pay Dr. Goldstein a consulting
fee of  $5,000  per  month,  $3,000  of which is paid in cash and the  remaining
$2,000 of which is retained by the Company and applied  toward  repayment of the
loan.

         Consulting  Agreement.  On August 16, 1999, the Company entered into an
agreement with Dr. Goldstein, J.J. Finkelstein,  Richard J. Hindin and Sidney J.
Silver to serve as financial and business  consultants to the Company and manage
the Company's affairs on an interim basis. This agreement was executed following
suspension of the Company's operating  activities due to insufficient funds. The
agreement  provides for the  consultants to prepare a business plan specifying a
proposed  business   strategy  for  the  Company  and  evaluate   financing  and
recapitalization  proposals. The agreement also provides for the consultants to,
among  other  things:   work  with  the  Company's  creditors  to  eliminate  or
restructure  its debts;  work with  governmental  agencies to ensure  regulatory
compliance and allow

                                        9

<PAGE>



continuation of the Company's  business;  recruit  necessary  management for the
Company;  and negotiate with companies interested in licensing or other business
and financial relationships with the Company.

         In  consideration  for services  provided to the  Company,  each of the
consultants was granted an option to purchase 1,875,000 shares of Company common
stock at an exercise  price of $.04 per share,  the then-fair  market value.  In
February  2000,  each  consultant  exercised  his  option in full.  The  Company
accepted from each  consultant as payment of the $75,000  exercise  price a note
payable to the Company in the amount of $75,000,  accruing interest at 6.09% per
annum and payable  quarterly for 36 months  beginning June 1, 2000. Each note is
secured  by the shares of Company  common  stock  issued  upon  exercise  of the
consultant's option. Mr. Finkelstein,  who is responsible for performing certain
operating  functions of the Company,  also receives a monthly fee of $8,000.  In
addition,  as noted above,  Dr. Goldstein is paid a consulting fee of $5,000 per
month.  Mr.  Silver is a partner  in the law firm of  Silver,  Freedman  & Taff,
L.L.P.  This firm has  represented  the  Company in a variety of legal  matters,
including the negotiation of settlements  with certain  creditors and agreements
with certain other parties.

           PROPOSAL 2 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
                          TO CHANGE THE COMPANY'S NAME

         The corporate  name of the Company is currently  "Alpha 1  Biomedicals,
Inc." This name reflects what had been the Company's  primary business focus for
most of its history,  namely,  the  commercialization  of Thymosin alpha 1, a 28
amino acid peptide  shown to regulate the immune  system in animal  models.  The
Company recently  significantly  reduced its commercial  development  efforts in
this area by selling all rights and  interests  it had in Thymosin  alpha 1. The
Company's  current primary business focus is the  commercialization  of Thymosin
beta 4, a 43 amino acid peptide. The Company is concentrating its efforts on the
use of Thymosin  beta 4 for the  treatment  of injured  tissue and non-  healing
wounds to enable more rapid repair and/or tissue regeneration. To better reflect
the Company's current primary business focus, the Board of Directors  recommends
to the stockholders for their approval at the annual meeting an amendment to the
Company's  certificate of incorporation to change the Company's name from "Alpha
1 Biomedicals, Inc." to "RegeneRx Biopharmaceuticals, Inc."

         If the  amendment  is  adopted,  the  first  section  of the  Company's
certificate of incorporation would be amended to read as follows:

         "1. Name. The name of the  corporation is RegeneRx  Biopharmaceuticals,
Inc."

Vote Required For Approval

         The  affirmative  vote of the holders of a majority of the  outstanding
shares  of  Company  common  stock is  required  for  approval  of the  proposed
amendment to change the Company's name.

         The Board of Directors recommends a vote FOR this proposal.

           PROPOSAL 3 - AMENDMENT TO THE CERTIFICATE OF INCORPORATION
                TO INCREASE THE AUTHORIZED SHARES OF COMMON STOCK

         On  August  10,  2000,  the  Board of  Directors  approved  a  proposed
amendment to the Company's  certificate of  incorporation to increase the number
of  authorized  shares  of  common  stock  of the  Company  from  20,000,000  to
100,000,000.  Stockholders are being asked to approve this proposed amendment at
the annual meeting.

         The Company's  certificate of  incorporation  currently  authorizes the
issuance of an aggregate  of  20,000,000  shares of common  stock and  1,000,000
shares of  preferred  stock.  As of October 23, 2000,  19,477,429  shares of the
common stock were issued and outstanding,  leaving only 522,571shares  available
for  issuance.  This is an  insufficient  number of  shares to cover the  shares
underlying the outstanding  warrants to purchase the Company's  common stock (of
which there are  1,326,666,  with exercise  prices ranging from $.10 to $.13 per
share).  If the  amendment is not  approved,  each of the four  consultants  has
agreed to permit the Company to  repurchase  from them shares at a price of $.04
per share (the exercise price of the options granted to the consultants pursuant
to the consulting  agreement and exercised by them in February  2000),  on a pro
rata basis, sufficient in number to allow for the exercise of any warrants

                                       10

<PAGE>



sought to be  exercised.  In addition,  if the  amendment is not  approved,  the
proposal to approve the Company's 2000 Stock Option and Incentive Plan (Proposal
4) will be deemed not to have been  approved.  No shares of preferred  stock are
outstanding.

         In  addition  to ensuring  there are a  sufficient  number of shares to
cover the Company's  outstanding stock options and warrants,  the amendment will
give the  Company  greater  flexibility  in its  financial  affairs by making 80
million  additional shares of common stock available for issuance by the Company
in such  transactions  and at such  times as the  Board of  Directors  considers
appropriate,  whether  in  public  or  private  offerings,  as stock  splits  or
dividends or in  connection  with mergers and  acquisitions  or  otherwise.  The
Company's stockholders may or may not be given the opportunity to vote on such a
transaction, depending on the nature of the transaction,  applicable law and the
judgment of the Company's  Board of Directors  regarding  the  submission of the
transaction to a vote of the Company's stockholders.  The Company has no present
plans or agreements for the issuance of the proposed additional shares of common
stock.

         The additional  shares of common stock authorized for issuance pursuant
to the proposed  amendment will have all of the rights and privileges  which the
presently outstanding shares of common stock possess; the increase in authorized
shares will not affect the terms,  or rights of holders,  of existing  shares of
common stock.  All outstanding  shares would continue to have one vote per share
on all matters to be voted on by the  stockholders,  including  the  election of
directors.  Holders of common stock have no preemptive or conversion  rights and
are not  subject  to  further  calls  or  assessments  by the  Company.  Because
stockholders  do  not  have  preemptive   rights,   the  interests  of  existing
stockholders may (depending on the particular  circumstances in which additional
capital  stock is issued) be diluted by any issuance of the proposed  additional
shares of common stock.

         It is possible that  additional  shares of common stock could be issued
for the purpose of making an acquisition by an unwanted  suitor of a controlling
interest in the Company more difficult, time-consuming or costly or to otherwise
discourage   an  attempt  to  acquire   control  of  the  Company.   Under  such
circumstances,  the  availability  of authorized and unissued shares may make it
more  difficult  for  stockholders  of the Company to obtain a premium for their
shares.  These  authorized and unissued shares could be used to create voting or
other  impediments  or to frustrate a person or other  entity  seeking to obtain
control of the  Company by means of a merger,  tender  offer,  proxy  contest or
other means. For instance,  shares could be privately placed with purchasers who
might  cooperate with the Company's Board of Directors in opposing an attempt by
a third party to gain  control of the  Company by voting the shares  against the
transaction  with the third party or could be used to dilute the stock ownership
or voting rights of a person or entity seeking to obtain control of the Company.

         Although the Company's Board of Directors does not currently anticipate
issuing  additional shares of common stock for purposes of preventing a takeover
of the Company,  the Company's Board of Directors reserves its right (consistent
with its fiduciary responsibilities) to issue shares for that purpose.

         If the proposed amendment is adopted,  the first sentence of the fourth
section of the Company's  certificate of incorporation  would be amended to read
as follows:

         "4.  Authorized  Capital  Stock.  The total number of shares of capital
stock which the Corporation shall have the authority to issue is One Hundred One
Million  (101,000,000)  shares  divided  into two  classes of which One  Million
(1,000,000)  shares  of the par value of $.001  per  share  shall be  designated
Preferred Stock and One Hundred Million (100,000,000) shares of the par value of
$.001 per share shall be designated Common Stock."

Vote Required For Approval

         The  affirmative  vote of the holders of a majority of the  outstanding
shares  of  Company  common  stock is  required  for  approval  of the  proposed
amendment to increase the number of authorized shares of common stock.

         The Board of Directors recommends a vote FOR this proposal.



                                       11

<PAGE>



        PROPOSAL 4 - APPROVAL OF THE 2000 STOCK OPTION AND INCENTIVE PLAN

Purpose

         The purpose of the 2000 Stock Option and  Incentive  Plan is to promote
the long-term  interests of the Company and its  stockholders  by attracting and
retaining  directors,   officers,   employees,   consultants  and  advisors  and
motivating these persons to exert their best efforts on behalf of the Company.

         In furtherance of these  objectives,  the Company's  Board of Directors
has adopted the Stock Option Plan,  subject to approval by the  stockholders  at
the annual  meeting.  If Proposal 3, the  proposed  amendment  to the  Company's
certificate of incorporation to increase the number of authorized shares, is not
approved,  then the proposal to approve the Stock Option Plan will be deemed not
to have been approved.  This is because the remaining number of shares currently
authorized  for issuance is not  sufficient to allow for the exercise of options
granted under the Stock Option Plan.

         A summary of the Stock Option Plan is set forth below. This summary is,
however,  qualified by and subject to the more complete information set forth in
the Stock Option  Plan,  a copy of which is attached to this proxy  statement as
Appendix A.

Administration of the Stock Option Plan

         The Stock Option Plan will be administered by a committee  comprised of
either each member of the Board of Directors or two or more members of the Board
of  Directors  appointed  by the  Board of  Directors,  each of whom  must be an
"outside director," as defined in Section 162(m) of the Internal Revenue Code of
1986, as amended, and a "non-employee  director," as defined in Rule 16b-3 under
the Securities Exchange Act of 1934, as amended. The Committee will:

         o    select  persons  to  receive   options  from  among  the  eligible
              participants;

         o    determine  the  number of shares  underlying  options  granted  to
              participants;

         o    set the terms, conditions and provisions of the options consistent
              with the terms of the Stock Option Plan; and

         o    establish rules for the administration of the Stock Option Plan.

The  Committee  has the power to interpret the Stock Option Plan and to make all
other determinations necessary or advisable for its administration.

         In granting  options under the Stock Option Plan,  the  Committee  will
consider,  among other factors,  the value of the  individual's  services to the
Company, and the added  responsibilities of such individual being in the service
of a public company.

Number of Shares That May Be Awarded

         Under the Stock Option Plan,  the  Committee  may grant  options for an
aggregate of 1,000,000 shares of Company common stock.  This amount  represented
approximately  5.13 percent of the shares issued and  outstanding  as of October
23,  2000.  The Stock  Option Plan also  provides  that no person may be granted
options for more than 100,000 shares during any calendar year.

         The 1,000,000  shares of Company common stock available under the Stock
Option Plan are  subject to  adjustment  in the event of certain  changes in the
Company's  capitalization,  such as changes  resulting from stock  dividends and
stock splits.  As described in greater detail below,  the total number of shares
reserved  for issuance  under the Stock Option Plan may increase  over time as a
result of the "reload" feature contained in the Stock Option Plan.

                                       12

<PAGE>



Shares  underlying  options that expire or are  terminated  unexercised  will be
available again for issuance under the Stock Option Plan.

         The Stock Option Plan provides for the use of  authorized  but unissued
shares or treasury shares. Treasury shares are previously issued and outstanding
shares of Company  common stock which are no longer  outstanding  as a result of
having been repurchased or otherwise reacquired by the Company.

Reload Feature

         The number of shares  available for options under the Stock Option Plan
may be  increased,  from time to time and  without  stockholder  approval,  as a
result  of  the  plan's  "reload"  provision.   Under  the  "reload"  provision,
additional shares may be added to the remaining shares available under the Stock
Option Plan as follows:

         (i)      shares  repurchased  by the  Company,  in the open  market  or
                  otherwise,  with an  aggregate  price no greater than the cash
                  proceeds  received by the Company from the exercise of options
                  granted under the Stock Option Plan; and

         (ii)     any shares of Company common stock  surrendered to the Company
                  in  payment of the  exercise  price of stock  options  granted
                  under the Stock Option Plan.

Eligibility to Receive Awards

         The  Committee may grant  options to  directors,  officers,  employees,
consultants  and advisors of the Company.  The Committee  will select persons to
receive  options  among the eligible  participants  and  determine the number of
shares underlying the options to be granted.

Exercise Price of Options

         Under the terms of the Stock  Option  Plan,  the  exercise  price of an
option may not be less than the fair  market  value of the  common  stock on the
date  the  option  is  granted.  In the  case  of an  "incentive  stock  option"
(explained  below) granted to a person who is the beneficial  owner of more than
ten percent of the  outstanding  shares of Company  common  stock,  the exercise
price must not be less than 110% of the fair market value of the common stock on
the date of grant.

Exercisability of Options and Other Terms and Conditions

         Options under the Stock Option Plan may not be exercised later than ten
years after the grant date.  Subject to the limitations  imposed by the Internal
Revenue Code,  certain of the options granted under the Stock Option Plan may be
designated  "incentive  stock  options."  Incentive  stock  options  may  not be
exercised  later than ten years after the grant date,  except that an  incentive
stock option  granted to a person who is the  beneficial  owner of more than ten
percent of the  outstanding  shares of Company common stock may not be exercised
later than five years after the grant date.  Options which are not designated as
and do not  otherwise  qualify as  incentive  stock  options are  referred to as
"non-qualified stock options."

         The Committee  will determine the time or times at which a stock option
may be exercised in whole or in part and the method or methods by which, and the
form or forms in which, payment of the exercise price of the stock option may be
made. Unless otherwise  determined by the Committee and set forth in the written
award agreement  evidencing the grant of the stock option,  upon  termination of
service  of the  participant  for any reason  other  than for  cause,  all stock
options then currently  exercisable by the participant  will remain  exercisable
for the lesser of (i) three months following such termination of service (or one
year following such termination of service,  if the termination results from the
participant's  death or  disability)  and  (ii) the  period  of time  until  the
expiration  of the stock option by its terms.  Upon  termination  of service for
cause, all stock options not previously exercised will immediately be forfeited.


                                       13

<PAGE>



Effect of Change in Control

         Under the Stock  Option Plan,  if a tender offer or exchange  offer for
the Company's  common stock (other than an offer by the Company) is commenced or
a change in control of the Company  occurs,  unless the  Committee  has provided
otherwise  in the  award  agreement  evidencing  the  grant of the  option,  all
outstanding  options  granted  under the Stock  Option  Plan which are not fully
vested will vest in full. A "change in control" of the Company will be deemed to
occur if any of the following  events arise: (1) any person or group becomes the
beneficial  owner of 50  percent  or more of the  outstanding  shares of Company
common stock;  (2) as a result of or in  connection  with any cash tender offer,
merger, sale of assets or contested election, there is a change in a majority of
the Company's Board of Directors;  or (3) the Company's  stockholders approve an
agreement providing either for a transaction in which the Company will no longer
be an independent  publicly-owned  company or for a sale of all or nearly all of
the Company's assets.

Transferability of Options

         An incentive  stock option  awarded  under the Stock Option Plan may be
transferred  only upon the death of the holder to whom it has been  granted,  by
will or the laws of inheritance. A non-qualified stock option may be transferred
during the lifetime of the person to whom it was granted pursuant to a qualified
domestic  relations  order or by gift to any  member of the  person's  immediate
family or to a trust for the  benefit  of any member of the  person's  immediate
family.

Effect of Merger on Option or Right

         Upon a merger or other business  combination of the Company in which it
is not the surviving entity (or in which it is the surviving  entity,  but where
the shares of Company common stock are converted into other securities,  cash or
other  property),  the  Stock  Option  Plan  provides  that  each  holder  of an
outstanding  option will have the right,  after  consummation of the transaction
and during the  remaining  term of the option,  to receive upon  exercise of the
option an amount  equal to the  excess of the fair  market  value on the date of
exercise of the securities or other consideration  receivable in the transaction
in respect of a share of common  stock over the  exercise  price of the  option,
multiplied  by the number of shares of common  stock  with  respect to which the
option is exercised.  This amount may be payable fully in cash,  fully in one or
more of the kind or kinds of property payable in the  transaction,  or partly in
cash and  partly  in one or more of such kind or kinds of  property,  all in the
discretion of the Committee.

Amendment and Termination

         The Stock  Option  Plan will  remain in effect for a term of ten years,
after which no options may be granted.  The Board of  Directors  may at any time
amend,  suspend or  terminate  the Stock Option Plan or any portion of the Stock
Option Plan,  except to the extent  stockholder  approval is necessary under any
applicable federal or state law or regulation or the rules of any stock exchange
or automated  quotation  system on which the Company's  common stock may then be
listed or quoted,  or if the Company's  Board of Directors,  in its  discretion,
determines to seek stockholder approval. No amendment, suspension or termination
of the plan, however,  may impair the rights of any participant,  without his or
her consent, in any option grant made pursuant to the Stock Option Plan.

Federal Income Tax Consequences

         Under current  federal tax law, a  non-qualified  stock option  granted
under  the  Stock  Option  Plan will not  result  in any  taxable  income to the
optionee  at the time of grant or any tax  deduction  to the  Company.  Upon the
exercise of the  non-qualified  stock option,  the excess of the market value of
the shares acquired over their cost (i.e., the exercise price) is taxable to the
optionee as ordinary  income and is generally  deductible  by the  Company.  The
optionee's  tax basis for the  shares is the  market  value of the shares at the
time of exercise.  Upon the sale of the shares, any appreciation in value of the
shares from the time of exercise will be recognized by the optionee as a capital
gain; this capital gain will be a short-term capital gain (and taxed at ordinary
income  rates) if the shares are sold within one year after the  exercise  and a
long-term capital gain if the shares are sold more than one year after exercise.


                                       14

<PAGE>



         Neither the grant nor the exercise of an incentive stock option granted
under the Stock  Option  Plan will result in any  federal  tax  consequences  to
either the optionee or the Company.  Except as described  below, at the time the
optionee sells shares  acquired  pursuant to the exercise of an incentive  stock
option,  the excess of the sale price over the exercise  price will qualify as a
long-term  capital gain. If the optionee disposes of the shares within two years
of the date of grant or within one year of the date of exercise, an amount equal
to the  difference  between the fair  market  value of the shares on the date of
exercise and the exercise price will be taxed as ordinary income and the Company
will be entitled to a deduction in the same amount.  The excess,  if any, of the
sale price over the fair market  value at the time of exercise  will  qualify as
long-term  capital  gain if the  shares  are sold more  than one year  after the
option is exercised.  If the optionee  exercises an incentive  stock option more
than  three  months  after  his  or her  termination  of  employment,  he or she
generally is deemed to have  exercised a  non-qualified  stock option.  The time
frame  within  which  an  incentive  stock  option  may be  exercised  following
termination  of  employment is extended to one year if the  termination  results
from the death or disability of the optionee.

Vote Required for Approval

         The affirmative  vote of a majority of the votes cast by the holders of
shares  present at the annual meeting in person or by proxy and entitled to vote
is required to approve the Stock Option Plan.

         The Board of Directors recommends a vote "FOR" this proposal.

              PROPOSAL 5 - RATIFICATION OF APPOINTMENT OF AUDITORS

         PricewaterhouseCoopers  LLP, the  independent  accounting firm that was
previously engaged as the principal  accountant to audit the Company's financial
statements,  was dismissed effective April 25, 2000. The audit reports issued by
PricewaterhouseCoopers  LLP for the  years  ended  December  31,  1996  and 1997
contained  an  explanatory  paragraph  expressing  substantial  doubt  about the
ability of the Company to continue as a going concern. The change in accountants
was approved by the Company's Board of Directors.  During the Company's two most
recent fiscal years and the  subsequent  interim  period through April 25, 2000,
there were no disagreements between the Company and  PricewaterhouseCoopers  LLP
on any  matter  of  accounting  principles  or  practices,  financial  statement
disclosure,  or  auditing  scope or  procedure  which,  if not  resolved  to the
satisfaction    of    PricewaterhouseCoopers     LLP,    would    have    caused
PricewaterhouseCoopers  LLP to  make  reference  to the  subject  matter  of the
disagreement or disagreements  in its report.  Subsequent to March 6, 1998 there
were no reports issued by PricewaterhouseCoopers LLP.

         Effective  April  25,  2000,  the  Company  engaged  Reznick  Fedder  &
Silverman  P.C. as its principal  accountant  to audit the  Company's  financial
statements.  During the Company's  two most recent  fiscal years and  subsequent
interim periods prior to the engagement of Reznick Fedder & Silverman, P.C., the
Company did not, nor did anyone on the Company's behalf,  consult Reznick Fedder
& Silverman,  P.C. regarding either (A) the application of accounting principles
to a specified completed or proposed  transaction,  or the type of audit opinion
that might be  rendered  on the  Company's  financial  statements  as to which a
written  report or oral advice was provided to the Company that was an important
factor  considered  by the Company in  reaching a decision as to an  accounting,
auditing or financial reporting issue, or (B) any matter that was the subject of
a disagreement  between the Company and  PricewaterhouseCoopers  LLP or an event
described in paragraph 304(a)(1)(v) of the SEC's Regulation S-K.

         The Board of Directors has appointed  Reznick Fedder & Silverman,  P.C.
as principal accountant for the fiscal year ending December 31, 2000, subject to
the  ratification of the  appointment by  stockholders at the annual meeting.  A
representative  of Reznick  Fedder &  Silverman,  P.C. is expected to attend the
annual meeting to respond to appropriate  questions and will have an opportunity
to make a statement if he or she so desires.

Vote Required For Approval

         The affirmative  vote of a majority of the votes cast by the holders of
shares  present in person or by proxy at the annual meeting and entitled to vote
is required to approve the  ratification  of the appointment of Reznick Fedder &
Silverman, P.C. as the Company's independent auditors for the fiscal year ending
December 31, 2000.

         The Board of Directors recommends a vote "FOR" this proposal.

                                       15

<PAGE>



                                  OTHER MATTERS

         The  Board  of  Directors  knows  of no  other  business  that  will be
presented at the annual  meeting.  If any other matter properly comes before the
stockholders for a vote at the annual meeting, the Board of Directors, as holder
of your proxy, will vote your shares in accordance with its best judgment.


                             ADDITIONAL INFORMATION

Proxy Solicitation Costs

         The Company will pay the costs of soliciting proxies.  The Company will
reimburse  brokerage  firms and other  custodians,  nominees and fiduciaries for
reasonable  expenses  incurred  by  them  in  sending  proxy  materials  to  the
beneficial  owners of the Company's common stock. In addition to solicitation by
mail,  directors,  officers  and  employees  of the Company may solicit  proxies
personally  or  by  facsimile,   telegraph  or  telephone,   without  additional
compensation.

Stockholder Proposals for 2001 Annual Meeting

         If you intend to present a  stockholder  proposal at next year's annual
meeting, your proposal must be received by the Company at its executive offices,
located at 3 Bethesda Metro Center,  Suite 700,  Bethesda,  Maryland  20814,  by
December 26, 2000 to be eligible for inclusion in the Company's  proxy materials
for that meeting. Your proposal will be subject to the requirements of the proxy
rules adopted  under the  Securities  Exchange Act of 1934, as amended,  and the
Company's certificate of incorporation and bylaws and Delaware law.

         If you submit a proposal for presentation at next year's annual meeting
that is not intended for inclusion in the Company's proxy materials, the persons
named in the form of proxy  sent by the  Company to  stockholders  will have the
discretion to vote on your  proposal in  accordance  with their best judgment if
your  proposal  is not  received  at the main office of the Company by March 12,
2001.




                                       16

<PAGE>
                                                                      APPENDIX A

                            ALPHA 1 BIOMEDICALS, INC.

                      2000 Stock Option and Incentive Plan


       1. Plan  Purpose.  The  purpose of the Plan is to promote  the  long-term
interests  of the  Corporation  and its  stockholders  by  providing a means for
attracting  and  retaining  directors,  officers,  employees,   Consultants  and
Advisors of the  Corporation  and its Affiliates and to motivate such persons to
exert their best efforts on behalf of the Corporation and its Affiliates.

       2. Definitions. The following definitions are applicable to the Plan:

       "Advisor" -- means an advisor retained by the Corporation or an Affiliate
who:  (i) is a natural  person;  and (ii)  provides  bona fide  services  to the
Corporation or an Affiliate, which services are not in connection with the offer
or sale of securities in a capital-raising  transaction,  and do not directly or
indirectly promote or maintain a market for the Corporation's securities.

       "Affiliate" -- means any "parent corporation" or "subsidiary corporation"
of the  Corporation,  as such  terms are  defined  in  Sections  424(e) and (f),
respectively, of the Code.

       "Board" -- means the board of directors of the Corporation.

       "Cause" -- means Termination of Service by reason of personal dishonesty,
incompetence,  willful  misconduct,  breach of fiduciary duty involving personal
profit, intentional failure to perform stated duties or gross negligence.

       "Code" -- means the Internal Revenue Code of 1986, as amended.

       "Committee" -- means the Committee referred to in Section 3 hereof.

       "Consultant"  -- means a  consultant  retained  by the  Corporation  or a
Affiliate who: (i) is a natural person;  and (ii) provides bona fide services to
the  Corporation or an Affiliate,  which services are not in connection with the
offer  or  sale  of  securities  in a  capital-raising  transaction,  and do not
directly  or  indirectly  promote or  maintain  a market  for the  Corporation's
securities.

       "Corporation" -- means Alpha 1 Biomedicals, Inc., a Delaware corporation,
and any successor thereto.

       "Disability" -- has the meaning assigned to such term in Section 22(e)(3)
of the Code, or any successor provision.

       "Incentive Stock Option" -- means an option to purchase Shares granted by
the  Committee  which is intended to qualify as an incentive  stock option under
Section 422(b) of the Code.  Unless otherwise set forth in the Option Agreement,
any Option  which does not qualify as an  Incentive  Stock Option for any reason
shall be deemed ab initio to be a Non-Qualified Stock Option.

                                       A-1

<PAGE>



       "Market  Value" -- means,  on the date in  question  (or,  if the date in
question is not a trading  day, on the last  trading day  preceding  the date in
question), the per share closing price of the Shares on the principal securities
exchange on which the Shares are listed (if the Shares are so listed), or on the
Nasdaq Stock Market (if the Shares are listed on the Nasdaq Stock  Market),  or,
if not listed on a securities  exchange or the Nasdaq Stock Market,  the average
of the per share closing bid and ask prices of the Shares as reported on the OTC
Bulletin  Board,  or, if such bid and ask  prices  are not  reported  on the OTC
Bulletin  Board,  as reported by any  nationally  recognized  quotation  service
selected by the Committee,  or, if no such price  information  is reported,  the
fair market value on such date of a Share as the Committee shall determine.

       "Non-Qualified  Stock  Option"  -- means an  option  to  purchase  Shares
granted by the Committee which does not qualify, for any reason, as an Incentive
Stock Option.

       "Option" -- means an  Incentive  Stock  Option or a  Non-Qualified  Stock
Option.

       "Option  Agreement"  -- means the  agreement  evidencing  the grant of an
Option under the Plan.

       "Participant"  -- means any director,  officer,  employee,  Consultant or
Advisor of the Corporation or any Affiliate who is selected to receive an Option
pursuant to Section 5.

       "Plan" -- means  this Alpha 1  Biomedicals,  Inc.  2000 Stock  Option and
Incentive Plan.

       "Shares" -- means the shares of common stock of the Corporation.

       "Termination of Service" -- means  cessation of service,  for any reason,
whether voluntary or involuntary,  so that the affected individual is not either
(i) an employee of the Corporation or any Affiliate for purposes of an Incentive
Stock Option, or (ii) a director,  officer,  employee,  Consultant or Advisor of
the Corporation or any Affiliate for purposes of a Non-Qualified Stock Option.

       3.  Administration.  The  Plan  shall  be  administered  by  a  Committee
consisting  of either (i) each member of the Board,  or (ii) two or more members
of the Board  appointed  by the  Board,  each of whom (A)  shall be an  "outside
director,"  as  defined  under  Section  162(m)  of the  Code  and the  Treasury
regulations thereunder,  and (B) shall be a "non-employee  director," as defined
under Rule 16b-3 under the Securities  Exchange Act of 1934, as amended,  or any
similar or successor  provision.  Except as limited by the express provisions of
the Plan or by resolutions  adopted by the Board,  the Committee shall have sole
and complete  authority  and  discretion  to (i) select  Participants  and grant
Options;  (ii)  determine the number of Shares to be subject to types of Options
generally,  as well as to  individual  Options  granted  under the  Plan;  (iii)
determine the terms and conditions upon which Options shall be granted under the
Plan;  (iv)  prescribe the forms and terms of Option  Agreements;  (v) establish
from time to time  regulations  for the  administration  of the  Plan;  and (vi)
interpret the Plan and make all determinations deemed necessary or advisable for
the administration of the Plan.


                                       A-2

<PAGE>



       A majority of the Committee shall constitute a quorum,  and the acts of a
majority of the members present at any meeting at which a quorum is present,  or
acts approved in writing by a majority of the Committee without a meeting, shall
be acts of the Committee.

       4.     Shares Subject to Plan.

              (a)  Subject  to  adjustment  by the  operation  of Section 6, the
maximum  number of Shares with respect to which Options may be granted under the
Plan is 1,000,000,  plus (i) the number of Shares repurchased by the Corporation
in the open market or otherwise with an aggregate price no greater than the cash
proceeds  received by the Corporation from the exercise of Options granted under
the Plan; plus (ii) any Shares  surrendered to the Corporation in payment of the
exercise  price of Options  granted  under the Plan.  The Shares with respect to
which  Options  may be  granted  under  the Plan may be  either  authorized  and
unissued  Shares or  previously  issued Shares  reacquired  and held as treasury
Shares.  An Option which terminates shall not be considered to have been granted
under the Plan,  and new Options may be granted  under the Plan with  respect to
the number of Shares as to which such termination has occurred.

              (b)  During  any  calendar  year,  no  Participant  may be granted
Options  under the Plan with  respect to more than  100,000  Shares,  subject to
adjustment as provided in Section 6.

       5.  Options.  The  Committee  is hereby  authorized  to grant  Options to
Participants  with the following  terms and conditions and with such  additional
terms and  conditions not  inconsistent  with the provisions of the Plan and the
requirements of applicable law as the Committee shall determine:

                    (i)  Exercise  Price.  The  exercise  price per Share for an
Option  shall be  determined  by the  Committee;  provided,  however,  that such
exercise price shall not be less than 100% of the Market Value of a Share on the
date of  grant  of  such  Option;  provided,  further,  that  in the  case of an
Incentive  Stock Option granted to an individual  who, at the time of grant,  is
the  beneficial  owner of stock  possessing  more than ten  percent of the total
combined  voting  power  of all  classes  of  stock  of the  Corporation  or any
Affiliate (a "Ten Percent  Owner"),  such exercise  price shall not be less than
110% of the Market Value of a Share on the date of grant of such Option.

                    (ii) Option Term.  The term of each Option shall be fixed by
the  Committee,  but  shall  be no  greater  than  ten  years  in the  case of a
Non-Qualified  Stock Option,  ten years in the case of an Incentive Stock Option
granted to a Participant  who is not a Ten Percent Owner,  and five years in the
case of a Incentive  Stock Option granted to a Participant  who is a Ten Percent
Owner.

                    (iii) Number of Shares and Time and Method of Exercise.  The
Committee  shall  determine the number of Shares  underlying each Option and the
time or times at which an Option  may be  exercised  in whole or in part and the
method  or  methods  by  which,  and  the  form  or  forms  (including,  without
limitation, cash, Shares, or any combination thereof, having a fair market value
on the exercise date equal to the relevant exercise price) in which,  payment of
the exercise price with respect thereto may be made or deemed to have been made.

                                       A-3

<PAGE>



                    (iv) Incentive Stock Options. Incentive Stock Options may be
granted by the Committee only to employees of the Corporation or its Affiliates.
No Incentive Stock Option may be granted more than ten years after the effective
date of the  Plan,  as set forth in  Section  14.  The  aggregate  Market  Value
(determined as of the time any Incentive  Stock Option is granted) of the Shares
with respect to which Incentive Stock Options are exercisable for the first time
by a Participant in any calendar year shall not exceed $100,000.

                    (v) Termination of Service.  Unless otherwise  determined by
the Committee and set forth in the Option Agreement  evidencing the grant of the
Option,  upon  Termination of Service of a Participant for any reason other than
for Cause or due to death or Disability, each Option granted to the Participant,
to the extent then exercisable,  shall remain  exercisable for the lesser of (A)
three months  following  such  Termination of Service and (B) the period of time
until the expiration of the Option by its terms. Unless otherwise  determined by
the Committee and set forth in the Option Agreement  evidencing the grant of the
Option, upon Termination of Service of a Participant due to death or Disability,
each Option granted to the Participant,  to the extent then  exercisable,  shall
remain  exercisable for the lesser of (A) one year following such Termination of
Service  and (B) the  period of time until the  expiration  of the Option by its
terms.  Upon  Termination  of Service of a  Participant  for Cause,  each Option
granted  to the  Participant,  to the  extent not  previously  exercised,  shall
immediately be forfeited.

       6. Adjustments Upon Changes in Capitalization. In the event of any change
in the outstanding Shares subsequent to the effective date of the Plan by reason
of  any   reorganization,   recapitalization,   stock  split,   stock  dividend,
combination or exchange of shares,  merger,  consolidation  or any change in the
corporate  structure or Shares of the Corporation,  the maximum aggregate number
and class of shares as to which  Options  may be granted  under the Plan and the
number and class of shares underlying outstanding Options granted under the Plan
(as  well as the  exercise  price  of each  such  outstanding  Option)  shall be
appropriately   adjusted  by  the  Committee,   whose   determination  shall  be
conclusive. Except as otherwise provided herein, any Option which is adjusted as
a result of this Section 6 shall be subject to the same terms and  conditions as
the original Option.

       7. Effect of Merger on Options. In the case of any merger,  consolidation
or  combination  of the  Corporation  (other  than a  merger,  consolidation  or
combination in which the  Corporation is the  continuing  corporation  and which
does not result in the outstanding  Shares being converted into or exchanged for
different securities,  cash or other property, or any combination thereof),  any
Participant to whom an Option has been granted shall have the  additional  right
(subject to the  provisions  of the Plan and any  limitation  applicable to such
Option),  thereafter  and during the term of each such  Option,  to receive upon
exercise  of any such  Option an amount  equal to the excess of the fair  market
value on the date of such exercise of the securities, cash or other property, or
combination thereof,  receivable upon such merger,  consolidation or combination
in respect of a Share over the exercise price of such Option,  multiplied by the
number of Shares with  respect to which such Option  shall have been  exercised.
Such  amount may be payable  fully in cash,  fully in one or more of the kind or
kinds of property  payable in such  merger,  consolidation  or  combination,  or
partly in cash and partly in one or more of such kind or kinds of property,  all
in the discretion of the Committee.

                                       A-4

<PAGE>



       8.  Effect of Change in  Control.  Each of the  events  specified  in the
following  clauses (i) through (iii) of this Section 8 shall be deemed a "change
in  control":  (i) any third  person,  including a "group" as defined in Section
13(d)(3) of the  Securities  Exchange Act of 1934, as amended,  shall become the
beneficial  owner of shares of the Corporation with respect to which 50% or more
of the total number of votes for the election of the Board may be cast,  (ii) as
a result of, or in  connection  with,  any cash  tender  offer,  merger or other
business  combination,  sale of assets or contested election,  or combination of
the foregoing,  the persons who were directors of the Corporation shall cease to
constitute a majority of the Board, or (iii) the stockholders of the Corporation
shall  approve an  agreement  providing  either for a  transaction  in which the
Corporation will cease to be an independent  publicly-owned corporation or for a
sale  or  other  disposition  of all or  substantially  all  the  assets  of the
Corporation.  If a tender offer or exchange offer for Shares (other than such an
offer by the  Corporation) is commenced,  or if a change in control shall occur,
unless the Committee shall have otherwise provided in the Option Agreement,  all
Options granted and not fully exercisable shall become  exercisable in full upon
the  happening  of such  event;  provided,  however,  that no  Option  which has
previously been exercised or otherwise terminated shall become exercisable.

       9. Assignments and Transfers. No Incentive Stock Option granted under the
Plan  shall  be  transferable  other  than by will or the  laws of  descent  and
distribution.  A  Non-Qualified  Stock Option shall be transferable by will, the
laws of descent and  distribution,  a "domestic  relations order," as defined in
Section  414(p)(1)(B) of the Code, or a gift to any member of the  Participant's
immediate  family or to a trust for the benefit of one or more of such immediate
family members.  During the lifetime of an Option recipient,  an Option shall be
exercisable  only by the  Option  recipient  unless it has been  transferred  as
permitted hereby, in which case it shall be exercisable only by such transferee.
For the purpose of this Section 9, a Participant's "immediate family" shall mean
the Participant's spouse, children and grandchildren.

       10.  Certain  Rights  Under the Plan.  No person shall have a right to be
selected as a Participant nor, having been so selected,  to be selected again as
a Participant, and no director, officer, employee,  Consultant, Advisor or other
person  shall have any claim or right to be granted an Option  under the Plan or
under any other  incentive or similar plan of the  Corporation or any Affiliate.
Neither the Plan nor any action taken hereunder shall be construed as giving any
employee,  Consultant or Advisor any right to be retained in the employ of or as
a Consultant or Advisor to the Corporation or any Affiliate.

       11. Delivery and Registration of Stock. The  Corporation's  obligation to
deliver Shares with respect to an Option shall, if the Committee so requests, be
conditioned upon the receipt of a representation as to the investment  intention
of the Participant to whom such Shares are to be delivered,  in such form as the
Committee  shall  determine  to be  necessary  or  advisable  to comply with the
provisions  of the  Securities  Act of 1933, as amended,  or any other  federal,
state  or  local   securities   legislation.   It  may  be  provided   that  any
representation  requirement shall become  inoperative upon a registration of the
Shares or other action  eliminating the necessity of such  representation  under
such Securities Act or other securities  legislation.  The Corporation shall not
be required to deliver any Shares  under the Plan prior to (i) the  admission of
such Shares to listing on any stock  exchange on which Shares may then be listed
and (ii) the completion of such

                                       A-5

<PAGE>



registration  or other  qualification  of such Shares under any state or federal
law, rule or  regulation,  as the Committee  shall  determine to be necessary or
advisable.

       12.  Withholding  Tax. Where a Participant or other person is entitled to
receive Shares  pursuant to the exercise of an Option  pursuant to the Plan, the
Corporation shall have the right to require the Participant or such other person
to pay the Corporation the amount of any taxes which the Corporation is required
to withhold with respect to such Shares, or, in lieu thereof, to retain, or sell
without notice, a number of such Shares  sufficient to cover the amount required
to be withheld.  All withholding  decisions pursuant to this Section 12 shall be
at the sole discretion of the Committee or the Corporation.

       13.    Amendment or Termination.

              (a) The Board may amend, alter, suspend, discontinue, or terminate
the Plan without the consent of  shareholders or  Participants,  except that any
such action will be subject to the  approval of the  Corporation's  shareholders
if, when and to the extent such  shareholder  approval is  necessary or required
for purposes of any  applicable  federal or state law or regulation or the rules
of any stock exchange or automated quotation system on which the Shares may then
be listed or quoted, or if the Board, in its discretion, determines to seek such
shareholder approval.

              (b) The  Committee  may waive any  conditions  of or rights of the
Corporation  or  modify  or amend  the  terms  of any  outstanding  Option.  The
Committee may not, however, amend, alter, suspend,  discontinue or terminate any
outstanding  Option without the consent of the  Participant  or holder  thereof,
except as otherwise provided herein.

       14. Effective Date and Term of Plan. The Plan shall become effective upon
the later of its  adoption by the Board or its approval by the  shareholders  of
the Corporation.  It shall continue in effect for a term of ten years thereafter
unless sooner terminated under Section 13 hereof.



                                       A-6

<PAGE>

                                 REVOCABLE PROXY
                            ALPHA 1 BIOMEDICALS, INC.
                         ANNUAL MEETING OF STOCKHOLDERS
                                December 15, 2000

         The  undersigned  hereby  appoints  the Board of  Directors  of Alpha 1
Biomedicals,  Inc.  (the  "Company"),  and its  survivor,  with  full  power  of
substitution,  to act as attorneys and proxies for the  undersigned  to vote all
shares of common stock of the Company which the  undersigned is entitled to vote
at the Annual Meeting of  Stockholders  (the  "Meeting"),  to be held on Friday,
December  15,  2000 at the Hyatt  Regency  Bethesda,  located at 7400  Wisconsin
Avenue, Bethesda,  Maryland 20814, at 10:00 a.m., local time, and at any and all
adjournments and postponements thereof, as indicated hereon.

THIS PROXY WILL BE VOTED AS DIRECTED, BUT IF NO INSTRUCTIONS ARE SPECIFIED, THIS
PROXY WILL BE VOTED FOR THE ELECTION OF THE  NOMINEES  NAMED HEREIN AND FOR EACH
OF THE PROPOSALS  LISTED ON THE REVERSE SIDE. IF ANY OTHER BUSINESS IS PRESENTED
AT THE  MEETING,  THIS PROXY WILL BE VOTED AS DIRECTED BY THE BOARD OF DIRECTORS
IN ITS BEST JUDGMENT.  AT THE PRESENT TIME,  THE BOARD OF DIRECTORS  KNOWS OF NO
OTHER BUSINESS TO BE PRESENTED AT THE MEETING.

         The  undersigned  acknowledges  receipt from the Company,  prior to the
execution of this Proxy, of Notice of the Meeting, the Company's Proxy Statement
and the Company's  Annual Report on Form 10-KSB for the year ended  December 31,
1999.

                         (To be Signed on Reverse Side)

<PAGE>
A |X|  Please mark
       your
       votes as in this
       example using
       dark ink only
<TABLE>
                                            The Board of Directors recommends a vote "FOR" the election of the
                                            nominees named herein and "FOR" each of the proposals listed below

             FOR all       WITHHOLD
             nominees      AUTHORITY
             listed at     to vote for
             right (except all nominees
             as indicated
             on the line
               below)                                                                                            FOR AGAINST ABSTAIN
<S>           <C>          <C>      <C>        <C>                   <C>   <C>                                    <C>    <C>  <C>
I. Election    o            o       Nominees:  ALLAN L. GOLDSTEIN    II.  The approval of a proposed amendment     o      o     o
   of                                          JOSEPH C. MCNAY            to the Company's certificate of
   Directors                                   ALBERT ROSENFELD           incorporation to change the Company's
   for one                                                                name from "Alpha 1 Biomedicals, Inc."
   year terms                                                             to RegeneRx Biopharmaceuticals, Inc."

Instructions: To withhold authority to vote from any                III.  The approval of a proposed amendment to     o      o     o
individual nominee but not all nominees, mark the                         the Company's certificate of incorporation
"FOR" box and write the name(s) of the nominee(s)                         to increase the number of shares of common
from which you wish to withhold your vote on the line                     stock authorized for issuance from 20,000,000
provided below.                                                           to 100,000,000.
--------------------------------------
                                                                     IV.  Conditioned upon approval of Proposal       o      o     o
                                                                          III, the approval of the Company's
                                                                          2000 Stock Option and Incentive Plan.

                                                                      V.  The ratification of the appointment of      o      o     o
                                                                          Reznick Fedder & Silverman, P.C. as
                                                                          independent auditors for the Company for
                                                                          the fiscal year ending December 31, 2000.

                                                                      In their discretion, the proxies are authorized to vote on any
                                                                      other business that may properly come before the Meeting or
                                                                      any adjournment or postponement thereof.

                                                                      THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                                                                     This proxy may be revoked at any time before it is voted by:
                                                                     (i)filing with the Secretary of the Company at or before the
                                                                     Meeting a written notice of revocation bearing a later date
                                                                     than this Proxy; (ii) duly executing a subsequent proxy
                                                                     relating to the same shares and delivering it to the Secretary
                                                                     of the Company at or before the Meeting; or (iii) attending
                                                                     the Meeting and voting in person (although attendance at the
                                                                     Meeting will not in and of itself constitute revocation of this
                                                                     Proxy).  If this Proxy is properly revoked as described above,
                                                                     then the power of such attorneys and proxies shall be deemed
                                                                     terminated and of no further force and effect.

                                                                     PLEASE PROMPTLY COMPLETE, DATE, SIGN AND MAIL THIS PROXY IN THE
                                                                     ENCLOSED POSTAGED-PAID ENVELOPE
</TABLE>


Sign and Print name of Stockholder_______________________________ Dated________
Sign and Print name of Stockholder_______________________________ Dated________

NOTE:  Please sign exactly as your name appears above on this card. When signing
as attor  executor,  administrator,  trustee or guardian,  please give your full
title. If shares are held jointly, each holder should sign. -























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