ALFACELL CORP
424B3, 1996-11-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                             File No. 333-11575
                                                Filed pursuant to Rule 424(b)(3)


                              ALFACELL CORPORATION


                                SUPPLEMENT NO. 1
                     TO PROSPECTUS DATED SEPTEMBER 13, 1996
          RELATING TO 2,042,506 SHARES OF COMMON STOCK, $.001 PAR VALUE

         The   Prospectus  is  hereby   supplemented   by  amending   "Executive
Compensation  - Summary  Compensation  Table" to reflect  the  extension  of the
exercise  period of the options  discussed  in  footnote  3, below,  so that the
Summary Compensation Table reads in its entirety as follows:


                           SUMMARY COMPENSATION TABLE

         The   following   table   provides  a  summary  of  cash  and  non-cash
compensation  for each of the last three fiscal years ended July 31, 1996,  1995
and 1994 with respect to  Alfacell's  Chief  Executive  Officer and the only two
other executive  officers of the Company during the last three fiscal years (the
"Named Executive Officers").

<TABLE>
<CAPTION>

                                                                                                   Long Term
                                                                                                 Compensation
                                                                                               ---------------
                                                     Annual Compensation
                                --------------------------------------------------------------
                                                                                                  Securities
                                                                                Other             Underlying
                                                                                Annual             Options/            All Other
           Name and                                                          Compensation           SARs(#)          Compensation
      Principal Position            Year      Salary($)      Bonus($)           ($)(1)         ---------------            ($)
- ----------------------------      -----     ----------     ---------      ----------------                         ---------------

<S>                                 <C>          <C>            <C>               <C>             <C>                      <C>
Kuslima Shogen                      1996         $150,000     - 0 -             - 0 -             500,000(3)             - 0 -
 Chief Executive Officer and        1995          150,000     - 0 -             - 0 -              - 0 - (4)             - 0 -
 Chairman of the Board of           1994          150,000     - 0 -             - 0 -            1,306,529(2)            - 0 -
 Directors(2)

Gail E. Fraser(5)                   1996         $130,000     - 0 -             - 0 -                - 0 -               - 0 -
 Vice President,                    1995          121,163     - 0 -             - 0 -              - 0 -(4)              - 0 -
 Finance and Chief                  1994            8,333     - 0 -             - 0 -              475,000(6)            - 0 -
 Financial Officer

Stanislaw M. Mikulski(7)            1996         $130,000     - 0 -             - 0 -             250,000(3)             - 0 -
 Executive Vice President           1995          130,000     - 0 -             - 0 -              - 0 - (4)             - 0 -
 and Medical Director               1994          130,000     - 0 -             - 0 -              431,409(7)            - 0 -


</TABLE>

(1)  Excludes  perquisites and other personal  benefits that in the aggregate do
     not exceed 10% of the Named  Executive  Officers'  total annual  salary and
     bonus.

(2)  Ms. Shogen resigned from her position as the Company's  President in August
     1996 and Chief  Financial  Officer in July 1994.  No salary was paid to Ms.
     Shogen in fiscal 1995 and 1994 and these salary amounts were accrued on the
     Company's financial statements as obligations owed

                                      - 1 -

<PAGE>



     to  Ms.   Shogen.   During  fiscal  1996,  Ms.  Shogen  was  paid  $225,978
     representing  payment in full of accrued back salary.  Ms.  Shogen was paid
     her salary in full for fiscal 1996.  In  consideration  for her services to
     the Company through January 31, 1994 and Ms. Shogen's  agreement to release
     the Company from its  obligation to pay her $1,624,151 in accrued salary on
     the  Company's  balance  sheet as of January  31,  1994,  in March 1994 the
     Company  granted  Ms.  Shogen  options to  purchase  841,529  shares of the
     Company's Common Stock at an exercise price of $3.20 per share.

(3)  These options were originally granted during the fiscal year ended July 31,
     1992, and were due to expire by their terms in September 1995. In September
     1995, the exercise  period for these options was extended  until  September
     1996 and the per share  exercise  price was  increased  to the fair  market
     value of the Common Stock on the date of such extension.

(4)  No options were granted to the Named  Executive  Officers during the fiscal
     year ended July 31, 1995.

(5)  Ms. Fraser  became an employee of the Company on July 15, 1994.  $96,163 of
     Ms. Fraser's salary in fiscal 1995 was paid to Ms. Fraser.  That portion of
     Ms.  Fraser's salary which was not paid to her was accrued on the Company's
     financial statements as obligations owed to Ms. Fraser. During fiscal 1996,
     Ms.  Fraser was paid $25,000  representing  payment in full of accrued back
     salary. Ms. Fraser was paid her salary in full for fiscal 1996.

(6)  Prior to Ms.  Fraser  joining the  Company,  Ms.  Fraser  received  under a
     consulting  agreement an option to purchase 50,000 and 75,000 shares of the
     Company's Common Stock at exercise prices of $3.22 and $5.00, respectively.
     On July 15, 1994, Ms. Fraser was granted options to purchase 350,000 shares
     of Common Stock under the Plan at an exercise price of $4.11 per share.

(7)  No salary was paid to Dr. Mikulski in fiscal 1994. $5,000 of Dr. Mikulski's
     salary in fiscal 1995 was paid to Dr.  Mikulski.  During  fiscal 1996,  Dr.
     Mikulski  was paid  $194,996  representing  payment in full of accrued back
     salary.  Dr.  Mikulski was paid his salary in full for fiscal  1996.  Those
     portions of Dr. Mikulski's salaries which were not paid to him were accrued
     on the Company's financial  statements as obligations owed to Dr. Mikulski.
     In  consideration  for his  services  to the  Company  and  Dr.  Mikulski's
     agreement to release the Company from its obligation to pay him $639,619 in
     accrued  salary on the  Company's  balance sheet as of January 31, 1994, in
     March 1994 the Company  granted Dr.  Mikulski  options to purchase  331,409
     shares of the  Company's  Common  Stock at an  exercise  price of $3.20 per
     share.


         The  Prospectus  is  further   supplemented   by  amending   "Executive
Compensation" to add the following table in its entirety:

                                      - 2 -

<PAGE>

                        OPTION GRANTS IN LAST FISCAL YEAR

         The following table contains information  concerning the grant of stock
options to the Named  Executive  Officers  during the fiscal year ended July 31,
1996.

<TABLE>
<CAPTION>

=====================================================================================================
                                         Individual Grants

- -----------------------------------------------------------------------------------------------------
                                                                                           Potential Realizable Value at Assumed
                                   % of Total Options        Exercise or                        Annual Rates of Stock Price
                   Options       Granted to Employees in     Base Price    Expiration         Appreciation for Option Term (2)
         Name    Granted (#)           Fiscal Year            ($/Share)       Date
                                                                                              
                                                                                       0%($)       5%($)        10%($)
- ------------------------------------------------------------------------------------------------------------------------------------

<S>               <C>                      <C>                 <C>         <C>           <C>   <C>            <C>     
Kuslima Shogen    500,000(1)                --                  $3.87       9/16/96       0     $96,750        $193,500

Gail E. Fraser        0                     --                   --            --         -           -               -

Stanislaw M.
  Mikulski        250,000(1)                --                   3.87       9/16/96       0     $48,375         $96,750
====================================================================================================================================
</TABLE>


(1)      These options were originally granted during the fiscal year ended July
         31, 1992 and were due to expire by their terms in  September  1995.  In
         September  1995, the exercise period for these options was extended and
         the per share  exercise price was increased to the fair market value of
         the Common Stock on the date of such extension.  The Board of Directors
         approved  extension  of  the  exercise  period  and  adjustment  of the
         exercise  price for these  options along with certain other options due
         to expire in 1995 as an inducement for the exercise of such options.

(2)      The amounts set forth in the three columns represent hypothetical gains
         that might be achieved by the optionees if the  respective  options are
         exercised at the end of their  terms.  These gains are based on assumed
         rates  of  stock  price   appreciation  of  0%,  5%  and  10%.  The  0%
         appreciation  column is  included  because  the  exercise  price of the
         options equals the market price of the  underlying  Common Stock on the
         date the  exercise  period of the options was  extended,  and thus will
         have no value  unless the  Company's  stock price  increases  above the
         exercise price.


         The  Prospectus  is  further   supplemented  by  amending  the  Selling
Stockholders'  Table to delete "Maronde,  John and Gretchen JT TEN" as a Selling
Stockholder,  include  their  transferee  as a Selling  Stockholder  and reflect
certain  other  private  transfers  of shares of Common  Stock  included  in the
Prospectus and made by other Selling Stockholders as follows:

<TABLE>
<CAPTION>

                                                                                                             Percentage
                                                                                                                 of
                                                                                                             Outstanding
                                                                                        Number of             Shares to be
                                                                                     Shares to be                Owned
                                                                                         Owned               Beneficially
                                       Number of                                     Beneficially                After
                                        Shares                 Number of                 After                Completion
                                     Beneficially               Shares                Completion                  of
Selling Stockholders                     Owned                  Offered               of Offering               Offering
- --------------------                     -----                  -------               -----------               --------

<S>                                        <C>                      <C>                       <C>                 <C>  
Dr. Walter Bloom                           24,000(6)                6,000                     18,000               *
Francesco Borghese                             1,500                1,500                          0               *
C.S.W. Investment Corp.                    18,000(6)               18,000                          0               *
Scott Farnum                                     500                  500                          0               *
Granite Securities Corporation             15,000(7)               15,000                          0               *
Lynn P. Harrington                             1,500                1,500                          0               *
JAM Trust                                     67,100               27,100                     40,000               *
Patricia H. Long                               1,000                1,000                          0               *
Douglas McIntyre                               1,000                1,000                          0               *
B. Michael Pisani                         279,500(7)              117,000                    162,500             1.10%
Michael B. Pisani                                500                  500                          0               *
John P. Pisani                                10,000               10,000                          0               *
Richard F. Siracusa                            8,000                1,000                      7,000               *
Michael R. Shaw                                1,600                1,000                        600               *

</TABLE>


(6)  Dr. Bloom's  beneficial  ownership  includes  18,000 shares owned by C.S.W.
     Investment Corp., which is a corporation controlled by Dr. Bloom.

(7)  Mr. Pisani's  beneficial  ownership includes 15,000 shares owned by Granite
     Securities Corporation, which is a corporation controlled by Mr. Pisani.

         All initially capitalized terms used herein shall have the same meaning
as specified in the Prospectus.


                The date of this Supplement is November 21, 1996


                                      - 3 -


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