ALFACELL CORP
PRE 14A, 1997-11-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                     PRE 14A
                                Preliminary Proxy

                            SCHEDULE 14A INFORMATION

                   Proxy Statement Pursuant to Section 14 (a)
                     of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[X]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted by 
     Rule 14a-6(e)(2)
[ ]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to ss. 240.14a-11 (C) or ss. 240.14a-12


                              ALFACELL CORPORATION
                (Name of Registrant as Specified In Its Charter)

                             KEVIN T. COLLINS, ESQ.
    (Name of Person (s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]  No Fee required
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(I) (4) and 0-11.

1)   Title of each class of securities to which transaction applies:

     ---------------------------------------------------------------------------

2)   Aggregate number of securities to which transaction applies:

     ---------------------------------------------------------------------------

3)   Per unit price or other underlying value of transaction  computed  pursuant
     to Exchange Act Rule 0-11. (Set forth the amount on which the filing fee is
     calculated and state how it was determined):

     ---------------------------------------------------------------------------

4)   Proposed maximum aggregate value of transaction:

     ---------------------------------------------------------------------------

5)   Total fee paid:

     ---------------------------------------------------------------------------

[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11 (a) (2) and identify the filing for which the  offsetting fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid: 
                                 -----------------------------------------------

     2)   Form, Schedule or Registration Statement No.
                                                      --------------------------

     3)   Filing Party:
                       ---------------------------------------------------------

     4)   Date Filed:
                     -----------------------------------------------------------


<PAGE>



                                Preliminary Copy

                              ALFACELL CORPORATION

                              225 Belleville Avenue
                          Bloomfield, New Jersey 07003
                                 (973) 748-8082

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD DECEMBER 9, 1997

To our Stockholders:

     You are hereby  notified  that the  annual  meeting  of  stockholders  (the
"Annual Meeting") of Alfacell Corporation, a Delaware corporation ("Alfacell" or
the "Company") will be held at the Radisson Suite Hotel Meadowlands, 350 Route 3
West, Mill Creek Drive, Secaucus, New Jersey 07094 on Tuesday,  December 9, 1997
at 10:00 a.m. local time, for the following purposes:

     1.   To elect five directors (Proposal No. 1);

     2.   To approve the Company's 1997 Stock Option Plan (Proposal No. 2);

     3.   To increase the number of authorized shares of Common Stock, par value
          $.001 (Proposal No. 3);

     4.   To  ratify  the  selection  of  KPMG  Peat  Marwick  LLP,  independent
          certified public accountants, to audit the financial statements of the
          Company for the fiscal year ending July 31, 1998 (Proposal No. 4); and

     5.   To transact  such other matters as may properly come before the Annual
          Meeting or any adjournment thereof.

     Only holders of record of the Company's  Common Stock,  par value $.001 per
share,  at the close of business  on October 20, 1997 are  entitled to notice of
and to vote at the Annual Meeting.

     Alfacell hopes that as many stockholders as possible will personally attend
the Annual Meeting. Whether or not you plan to attend the Annual Meeting, please
complete the enclosed  proxy card and sign,  date and return it promptly so that
your shares will be represented. Sending in your proxy will not prevent you from
voting in person at the Annual Meeting.

                                   By order of the board of directors,


                                   Gail E. Fraser, Secretary

Bloomfield, New Jersey
November ____, 1997

                                      - 2 -

<PAGE>



                              ALFACELL CORPORATION

                                    ---------

                                 PROXY STATEMENT

                                    ---------

     This Proxy  Statement is furnished in connection  with the  solicitation of
proxies for use at the annual meeting of stockholders  (the "Annual Meeting") of
Alfacell  Corporation  ("Alfacell"  or the  "Company")  to be held  on  Tuesday,
December  9, 1997 and at any  adjournment  thereof.  The  accompanying  proxy is
solicited  by the board of  directors  of the  Company and is  revocable  by the
stockholder  any time before it is voted.  For more  information  concerning the
procedure for revoking the proxy,  see "General." This Proxy Statement was first
mailed  to  stockholders  of the  Company  on or  about  November  _____,  1997,
accompanied by the Company's  Annual Report to Stockholders  for the fiscal year
ended July 31, 1997. The principal  executive offices of the Company are located
at  225  Belleville  Avenue,  Bloomfield,  New  Jersey  07003,  telephone  (973)
748-8082.


                      OUTSTANDING SHARES AND VOTING RIGHTS

      Only holders of the Company's common stock, par value $.001 per share
(the "Common Stock" or "Common Shares"), at the close of business on October 20,
1997 (the "Record  Date") are  entitled to receive  notice of and to vote at the
Annual  Meeting.  As  of  the  Record  Date,   14,847,793  Common  Shares,  were
outstanding  and will be  entitled  to vote at the Annual  Meeting.  Each Common
Share is entitled to one vote on all  matters.  There are no  cumulative  voting
rights.

     To be elected,  a director  must  receive a  plurality  of the votes of the
Common Shares  present in person or  represented  by proxy at the Annual Meeting
and entitled to vote on the election of directors.  The  affirmative  vote of at
least a majority of the  outstanding  Common Shares is required for the approval
of  Proposal  No. 3. The  affirmative  vote of at least a majority of the Common
Shares  present  in person or  represented  by proxy at the Annual  Meeting  and
entitled to vote  thereon,  whether or not a quorum is present  when the vote is
taken,  is necessary for approval of Proposal No. 2 and Proposal No. 4. A quorum
is  representation  in person or by proxy at the  Annual  Meeting  of at least a
majority of the Common Shares outstanding as of the Record Date.

     Pursuant to Delaware  General  Corporation  Law,  votes cast "For" a matter
constitute  affirmative votes. Proxy cards which are voted by marking "Withheld"
or "Abstain" on a particular  matter are counted as present for quorum  purposes
and for purposes of determining  the outcome of such matter,  but since they are
not cast "For" a particular  matter,  they will have the same effect as negative
votes or votes "Against" a particular  matter.  If a validly executed proxy card
is not marked to indicate a vote on a  particular  matter and the proxy  granted
thereby is not revoked  before it is voted,  it will be voted "For" such matter.
Where  brokers  are  prohibited  from  exercising  discretionary  authority  for
beneficial owners who have not provided voting  instructions  (commonly referred
to as "broker non-votes"), such broker non- votes will be treated as shares that
are present for purposes of determining  the presence of a quorum.  With respect
to proposals which require the affirmative vote of a percentage of votes present
at the Annual  Meeting for  approval,  however,  such broker  non-votes  will be
treated as not  present  for  purposes  of  determining  the outcome of any such
matters.  With  respect to proposals  which  require the  affirmative  vote of a
percentage of the outstanding  shares for approval,  since such broker non-votes
are not cast  "For" a  particular  matter,  they will have the same  effect as a
negative vote or votes "Against" such matter.


                                      - 3 -

<PAGE>



                     PROPOSAL NO. 1 - ELECTION OF DIRECTORS

     The Company  By-Laws  provide that the full Board of Directors shall not be
less than one, nor more than ten Directors, as may be fixed from time to time by
resolution of the Board of Directors.  The Board of Directors is currently fixed
at eight Directors and pursuant to a determination of the Board will be fixed at
five Directors as of the date of the Annual Meeting. Proxies cannot be voted for
a greater  number of persons than the number of nominees  named.  Directors  are
elected to serve until the next annual meeting of  stockholders  and until their
successors are elected and qualified.

     The  nominees  for  election  to  the  office  of  Director,   and  certain
information with respect to their ages and backgrounds,  are set forth below. It
is the intention of the persons  named in the  accompanying  proxy card,  unless
otherwise  instructed,  to vote to elect the nominees named herein as directors.
If any nominee declines to serve or becomes  unavailable for any reason, or if a
vacancy should occur before the election (although management knows of no reason
to  anticipate  that  this  will  occur),  the  proxies  may be  voted  for such
substitute  nominees as management  may designate.  Alan Bell,  Robert Henry and
Allen  Siegel have  elected to retire from the Board of  Directors  and will not
stand for election.

                 Nominees for Election to the Office of Director
                              at the Annual Meeting

<TABLE>
<CAPTION>
              Nominee            Age            Director         Position with the Company
              -------            ---            --------         -------------------------
                                                 Since
<S>                               <C>            <C>            <C>                                        
Kuslima Shogen                    52             1981           Chief Executive Officer, Chairman of the
                                                                Board

Gail E. Fraser                    39             1995           Vice President, Finance, Chief Financial
                                                                Officer and Director

Stanislaw M. Mikulski,            53             1986           Executive Vice President, Medical Director
M.D.                                                            and Director

Stephen K. Carter, M.D.(1)(2)     59             1997           Director and Chairman of the Scientific
                                                                Advisory Board

Donald Conklin (1)(2)             61             1997           Director
</TABLE>


(1)  Member of Compensation Committee
(2)  Member of Audit Committee


     The Board of Directors recommends a vote FOR Ms. Shogen and Ms. Fraser, Dr.
Mikulski,  Dr. Carter and Mr. Conklin as Directors  (Proposal No. 1 on the Proxy
Card).


                         BUSINESS EXPERIENCE OF NOMINEES

     Kuslima Shogen has served as the Company's  Chief  Executive  Officer since
September  1986,  Chairman of the Board since  August,  1996,  and as a Director
since the  inception  of the  Company.  She also served as the  Company's  Chief
Financial Officer from September 1986 through July 1994 and as its


                                      - 4 -

<PAGE>



President  from  September 1986 through July 1996. Ms. Shogen formed the Company
in 1981 to pursue research that she had initiated while a biology student in the
University Honors Program at Fairleigh Dickenson  University.  Prior to founding
Alfacell,  from  1976 to 1981 she was  founder  and  president  of a  biomedical
research  consortium  specializing  in  Good  Laboratory  Practices  and  animal
toxicology.  During  that time,  she also served as a  consultant  for the Lever
Brothers   Research  Group.   Ms.  Shogen  has  received   numerous  awards  for
achievements in biology,  including the Sigma Xi first prize from the Scientific
Research  Society  of  North  America  in 1974  and  first  prize  for the  most
outstanding research paper in biology at the Eastern College Science Conferences
competitions  in 1972,  1973, and 1974. She earned a B.S.  degree in 1974 and an
M.S.  degree in 1976 in biology from  Fairleigh  Dickenson,  and also  completed
graduate studies in 1978 in embryology. Ms. Shogen was the first teaching fellow
from Fairleigh Dickenson's Rutherford, NJ campus. She graduated Phi Beta Kappa.

     Gail E. Fraser  joined the Company as its Chief  Financial  Officer in July
1994 and subsequently became a Director in April, 1995. From August 1993 to July
1994, she served as a consultant to the Company and was the Company's  business,
financial and accounting  advisor.  From April 1989 to February 1993, Ms. Fraser
served as the  Chief  Financial  Officer  of Enzon,  Inc.,  a  biopharmaceutical
company located in Piscataway, New Jersey, where she was responsible for raising
more than $80 million in equity  capital.  From 1982 to 1989,  she served as the
Vice  President  of Finance and  Controller  for Sidmak  Laboratories,  Inc.,  a
generic drug manufacturer located in East Hanover, New Jersey. Ms. Fraser earned
a B.S.  degree in accounting  from Kean  University of New Jersey in 1985 and an
M.B.A. from the Wharton School of the University of Pennsylvania in 1993. She is
also a Certified Public Accountant in the state of New Jersey.

     Stanislaw M. Mikulski,  M.D., F.A.C.P.  has served the Company as Executive
Vice  President and Medical  Director  since 1987 and as a Director  since 1986.
Prior to his affiliation  with Alfacell,  Dr. Mikulski was Special  Assistant to
the Chief of the  Investigational  Drug Branch of the National Cancer  Institute
("NCI") and the Coordinator for Immunotherapy  Trials in Cancer for the Division
of Cancer  Treatment.  Prior to joining the  Company,  he  maintained  a private
practice in medical  oncology  for over eight  years.  He is a diplomate  of the
American Board of Internal  Medicine and Medical Oncology as well as a fellow of
the  American  College of  Physicians  and a member of the  American  Society of
Clinical Oncology.  Dr. Mikulski is currently a clinical assistant  Professor of
Medicine at the University of Medicine and Dentistry of New Jersey.  He received
his M.D.  in 1967 from the  Medical  School of Warsaw,  Poland and  subsequently
performed  post-doctoral  studies in human tumor immunology at the University of
California in Los Angeles.

     Stephen  K.  Carter,  M.D.  joined the Board of  Directors  in May 1997 and
serves as Chairman of the Company's  Scientific  Advisory  Board. In addition to
his  positions  with  Alfacell,  Dr.  Carter  also  serves as a senior  clinical
consultant  to Sugen,  Inc.  From 1995  through  1997,  he served as Senior Vice
President of Research and Development for Boehringer-Ingelheim  Pharmaceuticals.
Before  this,  Dr.  Carter  spent over 13 years with  Bristol-Myers  Squibb,  an
international  leader in the development of innovative  anticancer and antiviral
therapies.  He held a  variety  of senior  executive  research  and  development
positions  while at  Bristol-Myers,  including  serving for five years as Senior
Vice  President  of  worldwide  clinical  research  and  development  for  their
Pharmaceutical  Research  Institute.  From  1976 to  1982,  he  established  and
directed the Northern California Cancer Program. Prior to this, he held a number
of positions  during a nine-year  tenure at the NCI,  including  the position of
Deputy Director at the National  Institutes of Health. He has also been a member
of the faculties of the medical schools of Stanford  University,  the University
of  California  at San  Francisco,  and New  York  University.  Dr.  Carter  has
published   extensively  on  the  development  of  anticancer   drugs,  was  the
co-founding editor of journals devoted to cancer therapeutics or immunology, and
has served on the editorial boards of a number of


                                      - 5 -

<PAGE>



additional  journals  dedicated  to  cancer  treatment.  He is a  member  of the
American  Society of Clinical  Oncology,  the  American  Association  for Cancer
Research, and the Society of Surgical Oncology, as well as several other medical
societies. Dr. Carter earned his B.A. from Columbia University and his M.D. from
New York Medical College. He currently serves on the Board of Directors of Allos
Therapeutics.

     Donald R. Conklin  joined the Board of Directors in May 1997.  Prior to his
retirement in May 1997, Mr. Conklin was a senior executive with Schering-Plough,
a major  worldwide  pharmaceutical  firm.  During  his more  than 35 years  with
Schering-Plough,  he held a variety of key management positions within the firm.
From 1986 to 1994, he served as President of Schering-Plough Pharmaceuticals. In
this  position,  he was  responsible  for worldwide  pharmaceutical  operations,
including the launch of INTRON A(R)  (interferon  alfa-2b).  Prior to this,  Mr.
Conklin  had  served as  President  of  Schering  USA and had held a variety  of
executive marketing  positions in the United States,  Europe, and Latin America.
Immediately preceding his retirement,  he was Chairman of Schering-Plough Health
Care Products and an Executive  Vice President of  Schering-Plough  Corporation.
Mr. Conklin  received his B.A. with highest honors from Williams College and his
M.B.A.  degree from the Rutgers  University  School of  Business.  He  currently
serves   on  the  Board  of   Directors   of   Vertex   Pharmaceuticals,   Inc.,
CytoTherapeutics, Inc. and BioTransplant, Inc.

     The  SEC has  notified  Ms.  Shogen,  Dr.  Mikulski  and  Dr.  Siegel  (the
"Reporting  Persons") that the Division of Enforcement had commenced an informal
investigation  (the "SEC  Investigation")  of  certain  allegedly  late  filings
required to be made by the Reporting  Persons  pursuant to Sections 13 and 16 of
the  Securities  and Exchange Act of 1934 (the  "Exchange  Act") with respect to
changes in beneficial  ownership of the Company's  securities which occurred for
each of the Reporting  Persons during the years 1983 to 1994. The alleged filing
violations  relate solely to the filings of required forms, and to the Company's
knowledge,  the Enforcement  Division has not alleged any fraudulent  conduct by
any of the Reporting  Persons.  The Reporting  Persons and the Company have been
cooperating fully with the SEC in connection with its investigation. The SEC has
advised the Reporting  Persons that its staff is  considering  recommending  the
commencement of an enforcement proceeding in which the SEC would attempt to seek
a  cease-and-desist  order against the Reporting Persons and monetary  penalties
for all of the  Reporting  Persons  totaling  $55,000 as a result of the alleged
late filings. Settlement discussions between the staff and the Reporting Persons
are ongoing.  Since  mid-1994  when the Company and its officers and  directors,
with  the  assistance  of  the  Company's  current   securities   counsel  fully
implemented a comprehensive  Section 16(a)  compliance  program,  all changes of
beneficial  ownership  for the  Reporting  Persons which have occurred have been
reported on a timely  basis,  except for one late form  filing by Ms.  Shogen in
fiscal 1996 which was reported in the Company's fiscal 1996 Proxy Statement. See
"Compliance with Section 16(a) of the Exchange Act".


               INFORMATION CONCERNING BOARD AND COMMITTEE MEETINGS
                           AND COMMITTEES OF THE BOARD

     Seven  meetings of the  Company's  board of directors  were held during the
fiscal year ended July 31,  1997.  As of July 31,  1997 there were two  standing
committees of the Board, a Compensation Committee and an Audit Committee. During
fiscal 1997, the  Compensation  Committee was comprised of Alan Bell,  Robert R.
Henry and Allen Siegel. The primary functions of the Compensation  Committee are
to  administer  the 1993  Stock  Option  Plan and the 1997  Stock  Option  Plan,
determine the compensation of the Company's  officers and senior  management and
review compensation policy for all of the Company's employees.  The Compensation
Committee  met once  during the fiscal  year  ended  July 31,  1997.  All of the
decisions  regarding  executive  compensation  were  made  by  the  Compensation
Committee


                                      - 6 -

<PAGE>



during  the fiscal  year ended July 31,  1997.  During  fiscal  1997,  the Audit
Committee was comprised of Alan Bell and Robert R. Henry.

     The primary functions of the Audit Committee are to meet with the Company's
independent  auditors to discuss and review audit  procedures  and issues,  meet
with  management  on  matters  concerning  the  Company's  financial  condition,
internal  controls and year-end audit,  and report to the Board on such matters.
The Audit  Committee  met one time during the fiscal  year ended July 31,  1997.
During  fiscal  1997,  no  incumbent  director  attended  fewer than 75 % of the
aggregate  of the total  number of  meetings of the board of  directors  and the
total  number of  meetings  held by all  committees  of the board on which  such
director  served.  On October 31,  1997  Messrs.  Bell and Henry and Dr.  Siegel
retired from the  Compensation  Committee  and Mr.  Conklin and Dr.  Carter were
elected to the Compensation Committee. On October 31, 1997 Mssrs. Bell and Henry
retired from the Audit  Committee and Mr. Conklin and Dr. Carter were elected to
the Audit Committee.


                             EXECUTIVE COMPENSATION

Directors' Compensation

     Directors  receive no cash  compensation in consideration for their serving
on the Board of Directors.

     In  November  1993  and  January  1994,  the  Board  of  Directors  and the
stockholders,  respectively,  approved the Company's 1993 Stock Option Plan (the
"Plan")  which,  among other things,  provides for  automatic  grants of options
("Automatic  Grants") under a formula (the "Formula") to non-employee  directors
("Independent Directors" ) on an annual basis.

     The  Formula  provides  that (I) on each  December  31st  each  Independent
Director  receives  automatically  an option to  purchase  15,000  shares of the
Company's  Common  Stock  (the  "Regular  Grant");  and (ii) on the date of each
Independent  Director's  initial election to the Board of Directors,  such newly
elected Independent Director  automatically  receives an option to purchase such
Independent  Director's  pro rata share of the Regular  Grant  which  equals the
product of 1,250  multiplied  by the  number of whole  months  remaining  in the
calendar year (the "Pro Rata Grant").  Each option granted pursuant to a Regular
Grant and a Pro Rata Grant vests and becomes  exercisable  on the December  30th
following the date of grant.  Notwithstanding the foregoing,  an option will not
become exercisable as to any shares unless such Independent  Director has served
continuously  on the Board  during  the year  preceding  the date on which  such
options  are  scheduled  to vest and become  exercisable,  or from the date such
Independent  Director  joined the Board until the date on which such options are
scheduled  to  vest  and  become  exercisable;  provided,  however,  that  if an
Independent Director does not fulfill such continuous service requirement due to
such  Independent  Director's  death  or  disability  all  options  held by such
Independent  Director  nonetheless  vest and  become  exercisable  as  described
herein.  An option granted  pursuant to the Formula  remains  exercisable  for a
period of five years after the date the option first  becomes  exercisable.  The
per share  exercise  price of an option granted under the Formula is required to
be equal  to the fair  market  value of a share of  Common  Stock on the date of
grant.

     During the  fiscal  year ended July 31,  1997,  the  following  Independent
Directors  were granted the options  listed below  pursuant to the Formula under
the 1993 Plan and the Company's  1997 Stock Option Plan (the "1997  Plan").  The
exercise  prices of the options are equal to the fair market value of the Common
Stock on the date of grant.


                                      - 7 -

<PAGE>



Name                     Number of Options      Exercise Price       Expiration
- ----                     -----------------      --------------       ----------
                                                                  
Alan Bell                      15,000               $ 6.97            12/30/02
                                                                  
Stephen K. Carter               8,750               $ 5.20            12/30/02
                                                                  
Donald Conklin                  8,750               $ 5.28            12/30/02
                                                                  
Robert R. Henry                15,000               $ 6.97            12/30/02
                                                                  
Allen Siegel                   15,000               $ 6.97            12/30/02
                                                                  
                                                               
     The options  granted to Mssrs.  Bell and Henry and Dr. Siegel will vest and
become exercisable upon their retirement from the Board.

     If the 1997 Plan is approved by  stockholders,  Independent  Directors will
receive  automatic grants of options under that Plan pursuant to a formula which
is  substantially  identical to the Formula in the 1993 Plan.  See "Proposal No.
2."


                  COMPENSATION COMMITTEE INTERLOCKS AND INSIDER
                                  PARTICIPATION

     During the fiscal  year ended July 31,  1997,  the  members of the Board of
Directors  who served on the  Compensation  Committee  of the Board of Directors
were Alan Bell, Robert R. Henry and Allen Siegel.

     Dr.  Siegel  has made a  request  for  indemnification  by the  Company  in
connection  with  the  SEC's  informal   investigation   regarding  his  alleged
violations  of Section 16 of the Exchange  Act  pursuant to his  indemnification
agreement   with  the   Company.   See   "Certain   Relationships   and  Related
Transactions".

Summary Compensation Table

     The following  table  provides a summary of cash and non-cash  compensation
for each of the last  three  fiscal  years  ended July 31,  1997,  1996 and 1995
earned  by the  Chief  Executive  Officer  and the only  three  other  executive
officers of the Company during the last three fiscal years (the "Named Executive
Officers").


<TABLE>
<CAPTION>
                                                                                                Long Term
                                              Annual Compensation                              Compensation
                          -----------------------------------------------------------        ---------------
                                                                                              Securities
                                                                           Other Annual       Underlying         All Other
      Name and                                                             Compensation         Options/         Compensation
 Principal Position          Year         Salary($)         Bonus($)          ($)(1)            SARs(#)               ($)
- -----------------------    --------     -------------     -----------    ----------------    --------------    ----------------
<S>                          <C>           <C>               <C>               <C>             <C>                 <C>
Kuslima Shogen               1997          $150,000          - 0 -             - 0 -            - 0 - (3)           - 0 -
Chief Executive              1996           150,000          - 0 -             - 0 -           500,000(4)           - 0 -
Officer and                  1995           150,000          - 0 -             - 0 -             - 0 -              - 0 -
Chairman of the
Board of
Directors(2)
</TABLE>



                                      - 8 -

<PAGE>


<TABLE>
<CAPTION>
                                                                                                Long Term
                                              Annual Compensation                              Compensation
                          -----------------------------------------------------------        ---------------
                                                                                              Securities
                                                                           Other Annual        Underlying         All Other
      Name and                                                             Compensation         Options/         Compensation
 Principal Position          Year         Salary($)         Bonus($)          ($)(1)            SARs(#)               ($)
- -----------------------    --------     -------------     -----------    ----------------    --------------    ----------------
<S>                          <C>           <C>               <C>               <C>             <C>                 <C>
Michael C. Lowe              1997          $189,968          - 0 -             - 0 -           175,000(5)           - 0 -   
  President(5)               1996           - 0 -            - 0 -             - 0 -             - 0 -              - 0 -   
                             1995           - 0 -            - 0 -             - 0 -             - 0 -              - 0 -   
                                                                                                                          
Gail E. Fraser(6)            1997          $130,000          - 0 -             - 0 -             - 0 -(3)           - 0 -   
Vice President,              1996           130,000          - 0 -             - 0 -             - 0 -              - 0 -   
   Finance and               1995           121,163          - 0 -             - 0 -             - 0 -              - 0 -   
   Chief Financial                                                                                                       
   Officer                                                                                                                   
                                                                                                                          
Stanislaw M.                 1997          $130,000          - 0 -             - 0 -             - 0 -(3)           - 0 -   
Mikulski(7)                  1996           130,000          - 0 -             - 0 -           250,000(4)           - 0 -   
Executive Vice               1995           130,000          - 0 -             - 0 -             - 0 -              - 0 -   
 President and                                                                                                            
 Medical Director                                                                                                  
</TABLE>


(1)  Excludes  perquisites and other personal  benefits that in the aggregate do
     not exceed 10% of the Named  Executive  Officers'  total annual  salary and
     bonus.

(2)  No salary was paid to Ms. Shogen in fiscal 1995 and this salary was accrued
     on the Company's  financial  statements as obligations  owed to Ms. Shogen.
     During fiscal 1996,  Ms. Shogen was paid $150,000  representing  payment in
     full of accrued  back  salary.  Ms.  Shogen was paid her salary in full for
     fiscal 1996 and 1997.

(3)  Except for the options  granted to Dr. Lowe and  described  in note (5), no
     options were granted to the Named Executive Officers during the fiscal year
     ended July 31, 1997.

(4)  These options were originally granted during the fiscal year ended July 31,
     1992, and were due to expire by their terms in September 1995. In September
     1995, the exercise  period for these options was extended  until  September
     1996 and the per share exercise price was increased to $3.87 per share, the
     fair market value of the Common Stock on the date of such extension.  These
     options  were  exercised  at an  exercise  price of $3.87 per share  during
     fiscal 1996 and 1997. See "Option Exercises and Fiscal Year-End Values."

(5)  Dr. Lowe was hired as  President of the Company in August 1996 and resigned
     as of July 31, 1997. He was originally  granted options to purchase 650,000
     shares of Common  Stock at an exercise  price of $4.70 per share,  the fair
     market  value  of the  Common  Stock on the date of  grant.  Pursuant  to a
     separation  agreement  between Dr. Lowe and the Company,  of these options,
     100,000 options vested  immediately upon grant and expire January 31, 1999,
     75,000  options  vested July 31, 1997 and expire  January 31, 1999, and the
     remaining  475,000  options were canceled upon his resignation as President
     of the Company. See "Employment and Termination Agreements."

(6)  In fiscal 1995, $96,163 of Ms. Fraser's salary was paid to Ms. Fraser. That
     portion of Ms. Fraser's salary which was not paid to her was accrued on the
     Company's financial statements as


                                      - 9 -

<PAGE>



     obligations  owed to Ms.  Fraser.  During fiscal 1996,  Ms. Fraser was paid
     $25,000 representing payment in full of accrued back salary. Ms. Fraser was
     paid her salary in full for fiscal 1996 and 1997.

(7)  In fiscal 1995,  $5,000 of Dr.  Mikulski's salary was paid to Dr. Mikulski.
     That portion of Dr. Mikulski's salary which was not paid to him was accrued
     on the Company's financial  statements as obligations owed to Dr. Mikulski.
     During fiscal 1996, Dr. Mikulski was paid $125,000  representing payment in
     full of accrued back salary.  Dr.  Mikulski was paid his salary in full for
     fiscal 1996 and 1997.

Option Grants in Last Fiscal Year

     The following  table  contains  information  concerning  the grant of stock
options to the Named  Executive  Officers  during the fiscal year ended July 31,
1997:

<TABLE>
<CAPTION>
===================================================================================================================================
                                  Individual Grants
                                                                                                Potential Realizable Value at
                                                                                                Assumed Annual Rates of Stock
                                                                                                Price Appreciation for Option
                                                                                                          Term (1)
- ------------------------------------------------------------------------------------------
                       Number of
                      Securities          % of Total
                      Underlying        Options Granted     Exercise or
                        Options         to Employees in     Base Price      Expiration
        Name          Granted (#)         Fiscal Year        ($/Share)         Date
                                                                                         -------------------------------------------
                                                                                              0%($)         5%($)        10%($)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>                    <C>               <C>            <C>               <C>        <C>          <C>    
Kuslima Shogen             0                  --                --              --              -             -            -

Gail E. Fraser             0                  --                --              --              -             -            -

Stanislaw M.               0                  --                --              --              -             -            -
Mikulski

Michael C.            175,000(2)             61.4%             $4.70          1/31/99           0          $41,125      $82,250
Lowe
====================================================================================================================================
</TABLE>

(1)  The amounts set forth in the three  columns  represent  hypothetical  gains
     that might be  achieved  by the  optionees  if the  respective  options are
     exercised at the end of their terms. These gains are based on assumed rates
     of stock price  appreciation of 0%, 5% and 10%. The 0% appreciation  column
     is included  because the  exercise  price of the options  equals the market
     price of the underlying  Common Stock on the date the options were granted,
     and thus the options  will have no value unless the  Company's  stock price
     increases above the exercise price.

(2)  Dr. Lowe was hired as  President of the Company in August 1996 and resigned
     as of July 31, 1997. He was originally  granted options to purchase 650,000
     shares of Common  Stock at an exercise  price of $4.70 per share,  the fair
     market  value  of the  Common  Stock on the date of  grant.  Pursuant  to a
     separation  agreement  between Dr. Lowe and the Company,  of these options,
     100,000 options vested  immediately upon grant and expire January 31, 1999,
     75,000  options  vested July 31, 1997 and expire  January 31, 1999, and the
     remaining  475,000  options were canceled upon his resignation as President
     of the Company.



                                     - 10 -

<PAGE>





Option Exercises and Fiscal Year-End Values

     The following  table sets forth the  information  with respect to the Named
Executive  Officers  concerning  the exercise of options  during the fiscal year
ended July 31, 1997 and unexercised options held as of July 31, 1997.

<TABLE>
<CAPTION>
====================================================================================================================================
                                                               Number of Securities                  Value of Unexercised
                                                              Underlying Unexercised                  In-The-Money Options
                                                            Options at Fiscal Year-End              at Fiscal Year-End($)(2)
                                                                        (#)
- -------------------------------------------------------
                         Shares             Value
         Name          Acquired on        Realized       Exercisable        Unexercisable      Exercisable        Unexercisable
                      Exercise (#)         ($)(1)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                           <C>            <C>            <C>                    <C>           <C>                    <C>     
Kuslima Shogen                422,500        $295,170       1,245,967              430,240       $1,628,817             $569,890

Gail E. Fraser                   None            None         335,000              140,000         $143,300              $53,200

Stanislaw M.                  163,500        $138,902         325,128              106,281         $424,215             $140,302
Mikulski

Michael C. Lowe                  None            None         195,000                - 0 -          $27,400                - 0 -
====================================================================================================================================
</TABLE>

(1)  Based  upon the fair  market  value of the  purchased  shares on the option
     exercise date less the exercise price paid for the shares.

(2)  The fair market  value of the Common Stock at the fiscal year end was based
     on the average of the bid and asked price  ($4.49) for the Common  Stock as
     reported by the NASDAQ SmallCap Market on the last date of the fiscal year,
     July 31, 1997.


Employment and Termination Agreements

     On October 9, 1997 the Company  entered  into a  separation  agreement  and
general release (the  "Separation  Agreement") with Dr. Michael Lowe pursuant to
which (i) Dr. Lowe confirmed his resignation as president, director and employee
of the Company effective as of July 31, 1997, (ii) the Company agreed to pay Dr.
Lowe a total of $100,000  during the period  commencing  August 1, 1997  through
January  31,  1998,  (iii) the  Company  and Dr. Lowe agreed that of the 650,000
options  granted to Dr.  Lowe when he became the  Company's  president,  100,000
options  had vested  immediately  upon grant and will remain  exercisable  until
January 31, 1999, 75,000 options had vested as of August 1, 1997 and will remain
exercisable  until January 31, 1999 and 475,000 options were canceled as of July
31, 1997 (iv) the Company agreed under certain  circumstances  to pay for health
insurance for Dr. Lowe and his dependents  until July 31, 1998, (v) Dr. Lowe and
the Company  released each other from all claims and (vi) Dr. Lowe agreed not to
compete with the Company until January 31, 1998.



                                     - 11 -

<PAGE>



         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     During the fiscal  year ended July 31,  1997,  the  Compensation  Committee
consisted of three non-employee directors. The three directors who comprised the
Compensation  Committee during fiscal 1997 are retiring from the board effective
as of the date of the fiscal 1997 Annual Meeting and two non-employee  directors
were elected to replace the retiring directors on the Compensation  Committee on
October 31, 1997.  This report is rendered by the three directors who sat on the
Compensation  Committee  and  made  all  compensation  decisions  regarding  the
Company's  executive  officers,  including the Named  Executive  Officers in the
Summary Compensation Table, during fiscal 1997.

     As with many other  biotechnology  companies,  Alfacell's  current level of
development and the highly volatile  nature of  biotechnology  stocks in general
makes  executive  compensation  which is based on sales and earnings  goals,  or
strictly based on stock performance, impracticable. In determining compensation,
the Compensation Committee generally reviews the progress made by the individual
officer in attaining  his or her  individual  goals and the progress made by the
Company  in  its  drug  development  programs.  In  addition,  the  Compensation
Committee keeps the Company's stock performance in mind when making compensation
decisions.  Finally, the Compensation Committee generally reviews and takes into
account,  competitive  factors regarding  compensation.  The compensation of the
Company's  executive officers consists of three principal  components:  (I) base
salary and benefits,  (ii) a bonus based on individual  contributions  evaluated
against annual goals and (iii) long-term  incentives in the form of stock option
grants.

     Kuslima  Shogen,  Gail E.  Fraser and Dr.  Stanislaw  M.  Mikulski  did not
receive  any  salary  increases,  bonuses  or option  grants  for  fiscal  1997.
Considering  the fact that the  Company's  stock had not  performed  in a manner
which they considered to be satisfactory  given general market conditions and in
an attempt  to limit  increases  in cash  expenditures  (including  compensation
costs), these executive officers did not petition the Compensation Committee for
additional compensation even though the Company's goals as set forth at the 1996
Annual Meeting had satisfactorily been achieved. The amounts paid to Dr. Michael
Lowe were based upon arms-length  negotiations between the Company and Dr. Lowe,
taking into account competitive factors and Dr. Lowe's compensation at his prior
employer.

                                             THE COMPENSATION COMMITTEE

                                             Robert Henry, Chairman
                                             Alan Bell
                                             Allen Siegel



                                     - 12 -

<PAGE>



                      Stockholder Return Performance Graph
                      ------------------------------------

     The graph below summarizes the total cumulative  return  experienced by the
Company's  stockholders  from July 31,  1992 to July 31,  1997,  compared to the
NASDAQ Stock Market Index and the NASDAQ Pharmaceutical Index.

                COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN*
    AMONG ALFACELL CORPORATION, THE NASDAQ STOCK MARKET (U.S.) AND THE NASDAQ
                              PHARMACEUTICAL INDEX


- --------------------------------------------------------------------------------
Research Holdings, Ltd.                 Total Return - Data Summary
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
ACEL                                        Cumulative Total Return

- --------------------------------------------------------------------------------
                                7/92     7/93    7/94    7/95    7/96    7/97
- --------------------------------------------------------------------------------
ALFACELL CORPORATION             100     126      66      53      97      89
- --------------------------------------------------------------------------------
NASDAQ STOCK MARKET (U.S.)       100     122     125     176     191     283
- --------------------------------------------------------------------------------
NASDAQ PHARMACEUTICAL            100      80      71      99     120     141
INDEX
- --------------------------------------------------------------------------------

             SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     As of  October  25,  1996,  when the  Company  filed its  definitive  Proxy
Statement for fiscal year 1996 indicating that during the fiscal year ended July
31, 1996, the officers, directors and 10% beneficial owners of the Company filed
in a timely manner all reports required to be filed pursuant to Section 16(a) of
the Exchange  Act, the Company had received no forms or other  information  from
any reporting person  indicating that there were any  transactions  that had not
been  previously  fully  reported  which were not disclosed in a previous  proxy
statement or Form 10-KSB filed by the Company.  Thereafter,  the SEC advised the
Reporting Persons that forms reflecting  changes in their respective  beneficial
ownership of Alfacell  securities which occurred between three and fifteen years
ago, had been filed late.  The SEC also asked the  Reporting  Persons to confirm
whether  forms for all other  changes in  beneficial  ownership had in fact been
filed.

     The Reporting  Persons and the Company  voluntarily  undertook an extensive
search  for and  review of  records  to  determine  the extent to which any such
changes in beneficial ownership were not previously fully reported.  The Company
has learned of the following filing deficiencies:

     As of July 31, 1997, Kuslima Shogen had one late Form 3, 43 late Form 4s, 3
late Form 5s and 189 transactions not reported on a timely basis. As of July 31,
1997,  Ms.  Shogen  had  failed to file 40 Form 4s and had  failed to report 187
transactions.  Subsequent to July 31, 1997,  Ms. Shogen filed a Form 5 reporting
all such unreported transactions.

     As of July 31,  1997,  Stanislaw  Mikulski had one late Form 3, 8 late Form
4s, one late Form 5


                                     - 13 -

<PAGE>



and 11  transactions  not reported on a timely basis.  As of July 31, 1997,  Dr.
Mikulski  had failed to file 18 Form 4s, two Form 5s and had failed to report 79
transactions. Subsequent to July 31, 1997, Dr. Mikulski filed a Form 5 reporting
all such unreported transactions.

     As of July 31,  1997,  Allen Siegel had one late Form 3, 22 late Form 4s, 3
late Form 5s and 28 transactions  not reported on a timely basis. As of July 31,
1997,  Dr.  Siegel  had  failed to file 27 Form 4s, one Form 5 and had failed to
report 54  transactions.  Subsequent to July 31, 1997, Dr. Siegel filed a Form 5
reporting all such unreported transactions.


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The  following  table  sets  forth  certain  information  concerning  stock
ownership of each person who is the beneficial  owner of five percent or more of
the Company's  outstanding Common Stock, each of the current directors,  each of
the Named Executive Officers and all directors and executive officers as a group
as of October 10, 1997.


<TABLE>
<CAPTION>
                                                                                               Percentage of Common
Directors, Officers or 5% Stockholders(1)                            Number of Shares(2)       Stock Outstanding(3)
- -----------------------------------------                            -------------------       --------------------
<S>                                                                        <C>                         <C>  
Kuslima Shogen                                                             2,545,467 (4)               15.8%

Stanislaw M. Mikulski                                                        686,378 (5)                4.5%

Gail E. Fraser                                                               335,000 (6)                2.2%

Michael C. Lowe                                                              245,000 (7)                1.6%

Alan Bell                                                                     65,929 (8)                 *

Stephen K. Carter                                                             10,000 (9)                 *

Donald R. Conklin                                                            25,500 (10)                 *

Robert R. Henry                                                             237,550 (11)                1.6%

Allen Siegel                                                                198,562 (12)                1.3%

All executive officers and directors as a group
(eight persons)                                                           4,349,386 (13)               25.4%
</TABLE>


*    Less than one percent.

(1)  The address of all  officers and  directors  listed above is in the care of
     the Company.

(2)  All shares  listed are Common  Stock.  Except as discussed  below,  none of
     these  shares are  subject to rights to acquire  beneficial  ownership,  as
     specified in Rule  13d-3(d)(1)  under the Exchange Act, and the  beneficial
     owner has sole voting and investment power,  subject to community  property
     laws where applicable.

(3)  The percentage of stock  outstanding for each  stockholder is calculated by
     dividing (I) the number of shares of Common Stock deemed to be beneficially
     held by such  stockholder as of October 10, 1997 by (ii) the sum of (A) the
     number of shares of Common Stock outstanding as of October


                                     - 14 -

<PAGE>



     10, 1997 plus (B) the number of shares issuable upon exercise of options or
     warrants held by such stockholder  which were exercisable as of October 10,
     1997 or which will  become  exercisable  within 60 days after  October  10,
     1997.

(4)  Includes  1,245,967  shares subject to options which were exercisable as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997.

(5)  Includes  325,128  shares  subject to options which were  exercisable as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997.

(6)  Includes  335,000 shares  underlying  options which were  exercisable as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997.

(7)  Includes  195,000  shares  subject to options which were  exercisable as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10,  1997.  Dr. Lowe  resigned as a director  and  president of the
     Company as July 31, 1997.

(8)  Includes  45,000  shares  subject to options which were  exercisable  as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997 owned by Mr. Bell, 20,429 shares owned jointly by Mr. Bell
     and his  wife  and 500  shares  owned  by Mrs.  Bell.  Mr.  Bell  disclaims
     beneficial ownership as to the shares owned by his wife.

(9)  Includes  10,000 shares  underlying  options which were  exercisable  as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997.

(10) Includes  10,000 shares  underlying  options which were  exercisable  as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997.

(11) Includes  41,250  shares  subject to options which were  exercisable  as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October  10,  1997  and  20,000  shares  underlying   warrants  which  were
     exercisable as of October 10, 1997 or which will become  exercisable within
     60 days after October 10, 1997.

(12) Includes  45,000  shares  subject to options which were  exercisable  as of
     October  10,  1997 or which will  become  exercisable  within 60 days after
     October 10, 1997 owned by Dr. Siegel,  37,785 shares owned by Dr.  Siegel's
     wife, who is a former  employee of the Company and 20,000 shares subject to
     options which were  exercisable as of October 10, 1997 or which will become
     exercisable  within 60 days after  October 10,  1997 owned by Dr.  Siegel's
     wife. Dr. Siegel disclaims  beneficial  ownership as to the shares owned by
     his wife.

(13) Includes all shares owned  beneficially  by the directors and the executive
     officers named in the table.



                                     - 15 -

<PAGE>



                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     Effective May 31, 1993, the Company  restructured a pre-existing  bank note
(the "Note") to include the principal balance of $1,300,000, accrued interest of
$349,072,  and legal fees of  $50,000  into a new term loan of  $1,699,072  (the
"Term  Loan").  Interest  was to be  computed  at a rate of seven  and  one-half
percent (7.5%) per annum. The Term Loan was secured by substantially  all of the
assets of the Company.  Ms. Shogen had  personally  guaranteed  the Note and had
pledged certain  collateral,  including a majority of the shares of Common Stock
of the  Company  owned by her and certain  options,  as  additional  collateral,
pursuant  to a pledge  agreement  (the  "Pledge  Agreement")  dated May 31, 1993
between Ms. Shogen,  the Company and the bank. The Pledge Agreement  secured the
obligations  of the  Company to the bank  pursuant to the Term Loan as well as a
personal  loan  Ms.  Shogen  had  with  the  same  bank  (the  "Shogen   Loan").
Substantially  all of the  obligations  owed by the  Company to Ms.  Shogen were
subordinated  to the Note. In order to satisfy the Company's  obligations to the
bank pursuant to the Term Loan, from time to time, as contemplated by the Pledge
Agreement,  portions of the shares of Common  Stock  pledged by Ms.  Shogen have
been sold. During fiscal 1994, shares pledged by Ms. Shogen were sold in payment
of such obligation in the amount of $48,673 during the quarter ended October 31,
1993,  $15,945 during  November 1993,  $15,957 during  December 1993 and $15,704
during January 1994.  Through January 31, 1994, the monthly payments of interest
and  principal  under  the  Term  Loan  were  paid  primarily  pursuant  to this
procedure,  and subsequent to such time, have been paid directly by the Company.
The Term Loan  agreement  prohibited  the  issuance of any  shares,  or right to
purchase any shares of the Company's  stock if the result of such issuance would
be to decrease the ratio of the market value of Ms.  Shogen's  pledged  stock to
the aggregate  outstanding  debt under the Term Loan and the Shogen Loan,  below
1:1. In June 1994, the Shogen Loan and the related Pledge Agreement were amended
to provide for, among other things,  the issuance to Ms. Shogen,  and subsequent
pledge to the bank,  of certain  options to purchase  Common Stock issued to Ms.
Shogen in  connection  with the  conversion  to options of advances and interest
thereon made by Ms. Shogen to the Company and accrued  salary owed to Ms. Shogen
by the  Company.  Based upon the average of the closing bid and asked  prices on
July 31, 1997, the shares of the Company's Common Stock pledged by Ms. Shogen to
secure the Term Loan and the Shogen  Loan were valued at  $6,052,520  (excluding
the value of shares of Common Stock  underlying  certain  options pledged to the
bank) and the  aggregate  outstanding  debt of the Company  pursuant to the Term
Loan and the aggregate  outstanding  debt of Ms.  Shogen  pursuant to the Shogen
Loan  as of  July  31,  1997  was  $1,373,090  and  $700,402,  respectively.  In
connection with the Term Loan, Ms. Shogen also assigned to the bank her right to
payment of up to $200,000 of outstanding debt owed to her by the Company,  which
amount was paid to Ms. Shogen by the Company, and paid to the bank by Ms. Shogen
during fiscal 1995 and 1996. In November 1995, the Note was amended and restated
and the Term Loan agreement was amended to provide for,  effective as of October
1, 1995, among other things (I) the extension of the Term Loan from May 31, 1996
to August 31,  1997,  (ii) a  re-amortization  of the payment of  principal  and
interest based on a one hundred fifty (150) month amortization  schedule,  (iii)
an increase in the  interest  rate from seven and  one-half  percent  (7.5%) per
annum to eight  and  three  eights  percent  (8.375%)  per  annum,  and (iv) the
issuance  to the bank of a warrant to  purchase  10,000  shares of Common  Stock
through  August 31, 1997 at an exercise  price of $4.19 per share.  Such warrant
expired unexercised.  The Company had a verbal agreement with the bank to extend
the maturity  date of the Term Loan until  December 1, 1997 provided the Company
deposited a  compensating  balance in the amount of the principal  balance as of
the date the extension  was  negotiated  with the bank. On October 2, 1997,  the
Company elected to pay the entire Term Loan balance, including accrued interest,
in the amount of $1,376,646.

     In accordance  with their  respective  indemnification  agreements with the
Company,  Ms.  Shogen and Drs.  Mikulski and Siegel gave  written  notice to the
Company of their claims for indemnification of


                                     - 16 -

<PAGE>



all damages, judgments, settlements, costs and expenses of investigation,  costs
and expenses of defense of legal actions, claims and proceedings and any appeals
therefrom  incurred in connection with the SEC  Investigation and any related or
ancillary,  threatened or pending actions, suits or proceedings,  whether civil,
criminal,  administrative or  investigative.  As of July 31, 1997, the amount of
attorneys'  fees and expenses  incurred in responding  to the SEC's  requests of
information  in  connection  with the SEC  Investigation  totaled  approximately
$150,000.


                     PROPOSAL NO. 2 - 1997 STOCK OPTION PLAN

     The Board of Directors  (the  "Board") of the Company  recognizes  that the
Company  experiences  intense  competition  from other  companies  for  talented
managers and employees and that the ultimate success of the Company depends upon
its  ability  to  attract  and  retain  high  caliber  employees,  officers  and
directors.  The  Compensation  Committee  of the  Board  (the  "Committee")  has
determined that one of the most effective means to compete for such personnel is
through  the  issuance  of stock  options.  The  Committee  does not believe the
Company  is in a  position  to offer the type of  retirement  packages  normally
offered by larger corporations and thus has used the Company's 1993 Stock Option
Plan (the "1993  Plan") and now  intends to also use the 1997 Stock  Option Plan
(the "1997 Plan") to advance this compensation philosophy.

     Under the 1993 Plan, the Company reserved 3,000,000 shares for issuance. Of
such 3,000,000  shares,  as of October 10, 1997 a total of 2,504,702  shares are
subject to outstanding stock options, 40,000 shares have been issued pursuant to
the  exercise of options  granted and 455,298  shares are  available  for future
option grants.  Due to the relatively few shares  remaining under the 1993 Plan,
the  Board  determined  to  create a new  plan  designed  to meet the  Company's
compensation needs. The 1997 Plan was approved by the Board on May 22, 1997. The
following is a summary of the  relevant  terms of the 1997 Plan and so qualified
in its entirety by the text of the 1997 Plan attached to this proxy statement as
Appendix A.


                             1997 STOCK OPTION PLAN

     The 1997 Plan reserves a total of 2,000,000  shares for option  grants.  If
approved by the  shareholders,  the 1997 Plan will  terminate ten years from May
22,  1997 or May 22,  2007.  Options  may be granted  under the 1997 Plan to any
persons who are employees,  consultants,  advisors, or directors of the Company.
The Plan is to be  administered  by the full Board or the  Committee,  which may
make discretionary grants to persons meeting the eligibility criteria.  The 1997
Plan also provides for formula grants to independent directors.

     Options granted under the 1997 Plan are nonqualified options. The selection
of  participants,   allotment  of  shares,  determination  of  price  and  other
conditions  of  purchase  of such  options  will be  determined  by the Board or
Committee, in their sole discretion. The exercise price of discretionary options
shall be at least equal to the fair market value of the Common Stock on the date
of grant. Options constituting discretionary grants generally vest in increments
of 20% per year  beginning one year after grant date,  until fully  vested.  The
Board or Committee  can  exercise  discretion  to provide an  alternate  vesting
schedule,  but in no event may options  granted under the 1997 Plan be exercised
sooner than six months from the date of grant,  provided,  however,  that in the
event of a merger or  consolidation  of the  Company in which the Company is not
the surviving entity or a dissolution or liquidation of the Company, all options
shall become immediately exercisable. Once vested with respect to any portion of
an option


                                     - 17 -

<PAGE>



grant, an option holder may exercise the options for a period of five years. The
Board or the Committee may, in their discretion, extend the exercise period, but
in no event  will an option  granted  under the 1997 Plan  expire  more than ten
years after the date of grant.

     Under the 1997 Plan, each independent  director receives a formula grant of
options  to  purchase  15,000  shares per year,  provided  the  director  serves
continuously  on the Board for an entire  calendar year.  Formula grants will be
made on  December  31 of each  year.  During  the  year in which a  director  is
initially elected to the Board, the director is eligible for a pro rata grant of
options to purchase  1,250 shares for each full month  remaining in the calendar
year for which the  independent  director  initially  serves.  Formula grants of
options vest in their  entirety on December 30 of the year  following the grant,
provided the director has served  continuously on the Board during the preceding
year. The exercise  price of formula  options must equal 100% of the fair market
value of the Common Stock on the date of grant and in no event may be granted at
less than the par value of the Common Stock.

     Options  granted  under the 1997  Plan are  nontransferable  other  than to
immediate family members, by the laws of descent and distribution or pursuant to
a qualified  domestic relations order as defined under the Internal Revenue Code
of 1986.

     When an option holder ceases to be employed by the Company or to serve as a
director, the option holder loses the unvested portion of the options previously
granted.  Thereafter,  on the 190th day following the termination of employment,
the entire option terminates.  The Board or the Committee may, however, waive or
modify this provision.  Notwithstanding  this provision,  the Board or Committee
has  discretion  to  terminate  the options of any option  holder who engages in
activities  contrary to the best interests of the Company. In the event that the
employee  ceases to be employed by the Company due to death or  disability,  the
option holder's executors, administrators,  legatees, heirs or estate shall have
the right to  exercise  the option  under the same  conditions  under  which the
option  holder  would  have  been  able to  exercise  the  options.  Subject  to
compliance  with  applicable  laws and regulations and the consent of holders of
outstanding options, the Board can amend the 1997 Plan.

Tax Consequences

     An  optionee  will not  recognize  taxable  income for  Federal  income tax
purposes upon the receipt of an option under the 1997 Plan, and the Company will
not be entitled to a deduction upon the grant of an option.  Upon exercise of an
option,  the optionee will recognize  ordinary income equal to the excess of the
fair  market  value on the date of exercise of the Common  Stock  received  upon
exercise  over the  exercise  price for such  Common  Stock.  However,  any such
optionee  who is subject to the  trading  restrictions  of Section  16(b) of the
Exchange Act would,  unless the optionee elected to recognize ordinary income on
the  date of  exercise,  recognize  ordinary  income  on the date  such  trading
restrictions  terminate (the "Deferred  Date").  The amount of such income would
equal the excess of the fair  market  value on the  Deferred  Date of the Common
Stock  received  upon  exercise of the option over the  exercise  price for such
Common Stock, and the holding period for long-term  capital gain treatment would
not begin until the Deferred  Date.  The Company will be entitled to a deduction
equal to the amount of ordinary  income  recognized  by any optionee at the same
time that such optionee recognized such income.



                                     - 18 -

<PAGE>



                          PROPOSAL NO. 3 - APPROVAL OF
                 PROPOSED AMENDMENT TO THE COMPANY'S CERTIFICATE
              OF INCORPORATION TO INCREASE AUTHORIZED COMMON STOCK

     At present the Company is authorized to issue  25,000,000  shares of Common
Stock,  $.001 par value per share and 1,000,000 shares of Preferred Stock,  $.01
par value per share.  As of October 10, 1997,  there were no shares of Preferred
Stock outstanding.  Also as of that date, there were 14,847,793 shares of Common
Stock outstanding and 3,917,213 shares reserved for issuance pursuant to various
outstanding  options to purchase  Common  Stock,  455,298  shares  reserved  for
additional  options  which may be  granted  under the 1993  Stock  Option  Plan,
1,882,500 shares reserved for additional  options which may be granted under the
1997 stock  option  plan and 698,251  shares  reserved  pursuant to  outstanding
warrants to purchase  Common  Stock.  Thus,  as of October 10,  1997,  3,198,945
shares of Common Stock were available for issuance.

     The Board of  Directors  believes  that it is in the best  interest  of the
Company  to  increase  the  authorized  number of shares  of Common  Stock  from
25,000,000 to 40,000,000.  The Company may need to issue additional Common Stock
to obtain  additional  financing,  implement  additional  management or employee
incentive programs or consummate strategic  acquisitions,  technology or product
licensing  agreements.  On October 31,  1997,  the Board of  Directors  voted to
submit  to  a  vote  of   stockholders   an  amendment  to  the  Certificate  of
Incorporation  increasing the authorized  Common Stock.  Although the Company is
pursuing potential financing, the Company has no present agreement or commitment
to issue any of the additional shares provided for in this Proposal.

     If this Proposal is approved,  the  additional  authorized  Common Stock as
well as the currently  authorized but unissued Common Stock,  would be available
for issuance in the future for such corporate purposes as the Board of Directors
deems  advisable from time to time without  further action by the  stockholders,
unless such action is required by applicable law or by the rules of NASDAQ or of
any stock exchange upon which the Company's shares may then be listed.

     The  Company's  Common  Stock is  currently  quoted on the NASDAQ  SmallCap
market. One of the  non-quantitative  maintenance criteria recently approved for
NASDAQ securities requires stockholder approval for the establishment of certain
plans or arrangements by the Company or the issuance of designated securities by
the Company.  This criteria  provides that, for so long as the Company's  Common
Stock is included in the NASDAQ  SmallCap  market  stockholder  approval will be
required for (i) the  establishment  of a stock option or purchase plan or other
arrangement  made  pursuant  to which  stock  may be  acquired  by  officers  or
directors, except for warrants or rights issued generally to security holders of
the Company or broadly based plans or arrangements  including  other  employees,
and certain de minimus issuances  thereunder or issuances to induce  individuals
to enter employment contracts; (ii) the issuance of securities which will result
in a change of  control of the  issuer;  (iii) the  issuance  of  securities  in
connection with the acquisition of the stock or assets of another company (a) if
any  director,  officer or  substantial  stockholder  of the Company has a 5% or
greater interest (or such persons  collectively have a 10% or greater interest),
directly  or  indirectly,  in the  company  or assets to be  acquired  or in the
consideration  to be paid in the  transaction or series of related  transactions
and the present or potential issuance of Common Stock or securities  convertible
into or exercisable for Common Stock, could result in an increase in outstanding
Common  Shares  or voting  power of 5% or more,  or (b)  where  the  present  or
potential   issuance  of  Common  Stock,  or  securities   convertible  into  or
exercisable  for Common  Stock,  other than a public  offering for cash,  if the
Common Stock has, or will have upon issuance, voting power equal to or in excess
of  20% of the  voting  power  outstanding  before  the  issuance  of  stock  or
securities  convertible  into or exercisable  for Common Stock, or the number of
shares of Common Stock to be issued


                                     - 19 -

<PAGE>



is or will be equal to or in  excess  of 20% of the  number  of shares of Common
Stock  outstanding  before  the  issuance  of  stock or  securities;  or (iv) in
connection with a transaction,  other than a public offering,  involving (x) the
sale or issuance of Common Stock, or securities  convertible into or exercisable
for  Common  Stock,  at a price less than the  greater of book or market  value,
which together with sales by officers,  directors or substantial stockholders of
the Company  equals 20% or more of the Common Stock or 20% or more of the voting
power  outstanding  before  the  issuance,  or (y) the sale or  issuance  by the
Company of the Common Stock (or securities  convertible  into or exercisable for
Common  Stock)  equals  20% or more of the  Common  Stock  or 20% or more of the
voting power  outstanding  before the issuance for less than the greater of book
or market value of the stock.

     The  additional  authorized  shares of  Common  Stock  resulting  from this
Proposal  would  be the  same  as the  existing  shares  of  Common  Stock.  All
outstanding Common Stock would continue to have one vote per share. Stockholders
of the Company do not presently have preemptive rights nor will they as a result
of the Proposal.

     Authorized  shares of Common  Stock in excess of those  shares  outstanding
(including,  if  authorized,  the  additional  Common Stock provided for in this
Proposal) will remain available for general corporate purposes, may be privately
placed  and  can be used  to  make a  change  in  control  of the  Company  more
difficult.  Under  certain  circumstances,  the Board of Directors  could create
impediments to, or frustrate persons seeking to effect a takeover or transfer in
control  of the  Company  by  causing  such  shares  to be issued to a holder or
holders who might side with the Board of  Directors  in opposing a takeover  bid
that the  Board of  Directors  determines  is not in the best  interests  of the
Company and its stockholders, but in which unaffiliated stockholders may wish to
participate.  The existence of such shares might have the effect of discouraging
any attempt by a person,  through the  acquisition  of a  substantial  number of
shares of Common Stock, to acquire control of the Company, since the issuance of
such shares could dilute the Company's book value per share and the Common Stock
ownership of such person. One of the effects of the Proposal, if approved, might
be to render the  accomplishment  of a tender offer more difficult.  This may be
beneficial  to  management  in a hostile  tender  offer,  thus having an adverse
impact on stockholders who may want to participate in such tender offer.

     It should be noted that subject to the limitations  discussed above, all of
the types of Board action described in the preceding  paragraph can currently be
taken and that the power of the Board of Directors  to take such  actions  would
not be enhanced by the Proposal, although the Proposal would increase the number
of shares of Common Stock that are subject to such action.

     This Proposal and the Company's authorized but unissued Preferred Stock may
generally  be  classified  as  "anti-takeover"  measures  and  may  each,  or in
conjunction with each other, discourage attempted takeovers of the Company which
are not  approved by the Board of  Directors.  The Company does not believe that
any other provision of its current  Certificate of  Incorporation or By-Laws are
intended or would have the effect of  discouraging  or making more difficult the
acquisition of control of the Company.

     If the proposal is approved and the Amendment becomes effective,  the first
sentence of Article 4 of the Company's Certificate of Incorporation,  which sets
forth the Company's  presently  authorized capital stock will be amended to read
in its entirety as follows:

     "The total number of shares of capital  stock which the  Corporation  shall
have authority to issue is forty-one million (41,000,000) shares, of which forty
million (40,000,000) shares shall be Common


                                     - 20 -

<PAGE>



Stock,  par value $.001 per share, and one million  (1,000,000)  shares shall be
Preferred Stock, par value $.001 per share."

     The Board of  Directors  recommends  a vote FOR approval of an amendment to
the Company's  Certificate of Incorporation to increase the authorized shares of
Common Stock from 25,000,000 to 40,000,000 (Proposal No. 3 on the proxy card).



                    PROPOSAL NO. 4 - RATIFICATION OF AUDITORS

     On October 31, 1997, the board of directors  approved the retention of KPMG
Peat Marwick LLP ("KPMG"),  independent  certified public accountants,  to audit
the consolidated  financial statements of the Company for the fiscal year ending
July 31, 1998.  KPMG has served as auditor of the  financial  statements  of the
Company for each of the fiscal years since and including,  the fiscal year ended
July 31, 1993.  Representatives of KPMG are expected to be present at the Annual
Meeting and will have the opportunity to make a statement  should they desire to
do so. Such  representatives  are also  expected to be  available  to respond to
questions.

     The Board of Directors  recommends a vote FOR ratification of the selection
of KPMG Peat Marwick LLP, independent certified public accountants, to audit the
financial  statements  of the  Company  for the fiscal year ending July 31, 1998
(Proposal No. 4 on the Proxy Card).


                          ANNUAL REPORT TO STOCKHOLDERS

     The Company's  Annual Report to Stockholders for the fiscal year ended July
31, 1997 accompanies this Proxy Statement.


                             STOCKHOLDERS' PROPOSAL

     It is  anticipated  that  the  Company's  fiscal  1998  Annual  Meeting  of
Stockholders will be held on or about November 19, 1998. Stockholders who intend
to present  proposals at such Annual Meeting of  Stockholders  must submit their
proposals to the Secretary of the Company on or before July 14, 1998.


                                     GENERAL

     The cost of soliciting proxies will be borne by the Company. In addition to
the use of mails, proxies may be solicited by personal interview,  telephone and
telegraph,  and by  directors,  officers  and regular  employees of the Company,
without special compensation  therefor.  The Company expects to reimburse banks,
brokers  and other  persons  for their  reasonable  out-of  pocket  expenses  in
handling proxy materials for beneficial owners of the Company's Common Stock.

     Unless  contrary  instructions  are indicated on the proxy card, all Common
Shares  represented by valid proxies received pursuant to this solicitation (and
not  revoked  before  they are  voted)  will be voted  FOR the  election  of the
nominees for directors named herein and FOR Proposals Nos. 2, 3 and 4.



                                     - 21 -

<PAGE>



     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time before it is voted.  Proxies may be revoked by filing with
the Secretary of the Company  written notice of revocation  bearing a later date
than the proxy, by duly executing a subsequent proxy relating to the same Common
Shares or by attending  the Annual  Meeting and voting in person.  Attendance at
the Annual  Meeting will not in and of itself  constitute  revocation of a proxy
unless the  stockholder  votes his or her Common  Shares in person at the Annual
Meeting.  Any notice  revoking  a proxy  should be sent to the  Company,  at 225
Belleville  Avenue,  Bloomfield,  New Jersey  07003  Attention:  Gail E. Fraser,
Secretary.

     The board of directors knows of no business other than that set forth above
to be  transacted at the meeting,  but if other matters  requiring a vote of the
stockholders  arise,  the  persons  designated  as proxies  will vote the Common
Shares  represented  by the proxies in  accordance  with their  judgment on such
matters. If a stockholder  specifies a different choice on the proxy, his or her
Common Shares will be voted in accordance with the specification so made.

     Please complete,  sign and date the enclosed proxy card, which is revocable
as described herein, and mail it promptly in the enclosed postage-paid envelope.

     IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN,
SIGN AND RETURN THE  ACCOMPANYING  PROXY CARD, NO MATTER HOW LARGE OR SMALL YOUR
HOLDINGS MAY BE.


                                   By order of the board of directors,


                                   Gail E. Fraser, Secretary

Bloomfield, New Jersey
November ____, 1997



                                     - 22 -

<PAGE>


                              ALFACELL CORPORATION

                             1997 STOCK OPTION PLAN

     The purpose of this Plan is to encourage stock ownership by employees and
directors of, and independent consultants to, Alfacell Corporation, a Delaware
corporation (herein called the "Company"), to provide an incentive to such
persons to develop, expand and improve the profits and prosperity of the
Company, and to assist the Company in attracting key personnel and consultants
through the grant of Options to purchase shares of the Company's Common Stock.

1.   DEFINITIONS

          Unless otherwise required by the context:

          (a) "Board" shall mean the Board of Directors of the Company.

          (b) "Committee" shall mean the Compensation Committee of the Board,
     which is appointed by the Board, and which shall be composed of at least
     two members of the Board.

          (c) "Common Stock" shall mean the Common Stock of the Company, par
     value $.001.

          (d) "Company" shall mean Alfacell Corporation.

          (e) "Code" shall mean the Internal Revenue Code of 1986, as amended.

          (f) "Immediate Family Member" shall mean any child, stepchild,
     grandchild, parent, stepparent, grandparent, spouse, sibling,
     mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law,
     or sister-in-law of any Optionee.



<PAGE>


          (g) "Independent Director" shall mean a director who is not an
     employee of the Company.

          (h) "Non-Employee Director" shall have the meaning ascribed in Rule
     16b-3 ("Rule 16b-3") promulgated under the Securities Exchange Act of 1934,
     as amended.

          (i) "Option" shall mean a right to purchase Common Stock, granted
     pursuant to the Plan.

          (j) "Optionee" shall mean a person to whom an Option is granted.

          (k) "Option Price" shall mean the purchase price for Common Stock
     under an option, as determined in Section 7 below.

          (l) "Participant" shall mean an employee of the Company, a director of
     the Company, a consultant or advisor to the Company or any person to whom
     an Option is granted under the Plan.

          (m) "Plan" shall mean this Alfacell Corporation 1997 Stock Option
     Plan.

2.   STOCK TO BE OPTIONED

     The maximum number of shares of Common Stock which may be issued upon
exercise of Options granted pursuant to this Plan shall not exceed 2,000,000
shares of Common Stock of the Company. Such shares may be treasury shares or
shares of original issue or a combination of the foregoing. If any Option
terminates, expires or is canceled with respect to any shares of Common Stock,
new Options may thereafter be granted covering such shares of Common Stock.


<PAGE>


3.   ADMINISTRATION

     This Plan shall be administered by the Committee or the Board; provided,
however, that with respect to Options granted or to be granted to Employees who
are subject to the provisions of Section 16(b) of the Exchange Act (i) the
Committee shall be composed solely of two or more Non-Employee Directors
appointed by the Board, or (ii) if the Committee includes Directors who are not
Non-Employee Directors (A) such persons, by abstention or recusal, shall not
participate in the vote with respect to Options granted or to be granted to
Employees who are subject to the provisions of Section 16(b) of the Exchange
Act, and (B) the Committee shall include at least two Non-Employee Directors, or
(iii) notwithstanding (i) or (ii) above, the transaction upon which a vote is
being had shall otherwise be exempt pursuant to the provisions of Rule 16b-3(d).
Except with respect to Options granted pursuant to Sections 6.2 and 6.3 hereof,
the Committee or the Board shall make all decisions with respect to the
operations of the Plan, the participation in the Plan by employees or directors
of, or consultants or advisors to the Company, and with respect to the extent of
that participation. The interpretation and construction of any provision of the
Plan by the Board or the Committee shall be final. No member of the Board or the
Committee shall be liable for any action or determination made by him in good
faith.


<PAGE>



4.   ELIGIBILITY

     The Board or the Committee may grant Options to any director, officer
(including officers who are members of the Board of Directors), other employees
or consultants or advisors of the Company. Options may be awarded by the Board
or the Committee at any time and from time to time to new Participants, or to
then current Participants, or to a greater or lesser number of Participants, and
may include or exclude previous Participants, as the Board or the Committee
shall determine. Options granted at different times need not contain similar
provisions.

5.   OPTION AGREEMENTS

     Each Option granted under the Plan shall be evidenced by a stock option
agreement (a "Stock Option Agreement") duly executed on behalf of the Company
and by the Optionee; dated as of the applicable date of grant and shall state
the number of shares to which the Option pertains, the Option Price, and, except
for Options granted pursuant to Sections 6.2 and 6.3, such other terms,
provisions and conditions not inconsistent with the Plan, as the Board or the
Committee may approve subject to the terms of the Plan. The Stock Option
Agreement shall be signed on behalf of the Company by an officer or officers
delegated such authority by the Board or the Committee.

6.   OPTION GRANTS

     6.1 Discretionary Grants. Except for Options granted pursuant to Sections
6.2 and 6.3, the Board or the


<PAGE>


Committee may grant from time to time such number of Options with such terms as
they determine, to those meeting the eligibility requirements contained in
Section 4 hereof (each a "Discretionary Grant").

     6.2 Independent Directors' Regular Grants. An Option to purchase 15,000
shares of Common Stock shall automatically be granted to each Independent
Director on December 31st of each year (each an "Independent Director's Regular
Grant").

     6.3 Independent Directors' Pro Rata Grants. On the date of each Independent
Director's initial election to the Board pursuant to a vote of the Board, such
newly elected Independent Director shall automatically be granted such
Independent Director's pro rata share of the Regular Grant for the year in which
such Independent Director is first elected to the Board which shall equal the
product of 1,250 multiplied by the number of whole months remaining in the
calendar year in which such Independent Director is first elected to the Board
(each an "Independent Director's Pro Rata Grant").

7.   OPTION PRICE

     The Option Price for Common Stock under each Option shall be at least 100
percent of the fair market value of the Common Stock at the time the Option is
granted, but in no event less than the par value of the Common Stock. Except as
the Board or the Committee may otherwise determine in good faith due to a
limited or sporadic trading market for the Company's Common Stock, the fair
market value of the Common Stock shall equal the average


<PAGE>


of the high bid and the low asked prices for the Common Stock during the 20
trading days preceding the date the Option is granted as reported by Nasdaq.

8.   VESTING; EXERCISABILITY AND OPTION PERIOD

     8.1 Discretionary Grants. An Option granted pursuant to a Discretionary
Grant shall vest and become exercisable as to 20% of the shares underlying such
Option one year after the date of grant, and as to an additional 20% of the
shares each year thereafter, until the Option is fully vested and exercisable as
to all of the shares underlying such Option. Notwithstanding the foregoing, the
Board or the Committee may provide that an Option granted pursuant to a
Discretionary Grant will vest and become exercisable in accordance with such
other schedule as they may determine in their sole discretion and specify in the
Stock Option Agreement; provided, however, that in no event shall an Option
granted pursuant to a Discretionary Grant vest or become exercisable until a
period of at least six months has elapsed from the date of grant thereof.

     8.2 Independent Directors' Regular Grants. An Option granted pursuant to an
Independent Director's Regular Grant or an Independent Director's Pro Rata Grant
shall vest and become exercisable on the December 30th following the date of
grant. Notwithstanding the foregoing, an Option shall not become exercisable as
to any shares unless such Independent Director has served continuously on the
Board during the year preceding the date on which such Options are scheduled to
become exercisable, or during the period of time from the date such Independent
Directorjoined the Board until the date such Options are scheduled to become
exercisable if such Independent Director 


<PAGE>


joined the Board during such preceding year; provided, however, that if an
Independent Director does not fulfill such continuous service requirement due to
such Independent Director's death or disability (as hereinafter defined) all
Options held by such Independent Director shall nonetheless vest and become
exercisable as provided for herein by those persons specified in Section 11. For
the purposes of this Section 8.2, "disability" shall mean a physical or mental
condition which prevents an Independent Director from performing his or her
duties as an Independent Director for a continuous six month period or for a
total of six months during any eight month period.

     8.3 Termination of Employment. Except as provided in Section 8.4 hereof, if
a Participant who is an employee ceases to be employed by the Company, his or
her Options, unless otherwise exercised, shall terminate as of the close of
business on the one hundred and ninetieth (190th) day following the termination
of the Participant's employment with the Company; provided, however, that such
Participant may exercise his or her Options during such one hundred and ninety
(190) day period following such termination of employment only to the extent
that such Options had vested and became exercisable on the date of termination
of Participant's employment and only to the extent such Participant would have
otherwise been able to exercise such Options during such one hundred and ninety
(190) day period. Notwithstanding the foregoing, the Board or the Committee
may


<PAGE>


cancel an option during the one hundred and ninety (190) day period referred to
in this section, if the Participant engages in employment or activities
contrary, in the opinion of the Board or the Committee, to the best interests of
the Company. The Board or the Committee shall determine in each case whether a
termination of employment shall be considered a retirement with the consent of
the Company, and, subject to applicable law, whether a leave of absence shall
constitute a termination of employment. Any such determination of the Board or
the Committee shall be final and conclusive. The foregoing provisions may be
modified or waived by the Board or the Committee and do not, in any case, apply
to any Participant who is not an employee of the Company. The Board or the
Committee will determine who shall be deemed to be an employee of the Company
for the purposes of this Section 8.3 and Section 8.4 below at the time the
Option is granted and, except for Options granted pursuant to Independent
Directors' Regular Grants or Independent Directors' Pro Rata Grants, the Board
or the Committee will determine what, if any, provisions concerning exercise of
the Option upon the cessation of the service provided to the Company by a
non-employee will be included in the Stock Option Agreement issued to such
non-employee.

     8.4 Rights in Event of Death of Employee. If a Participant who is an
employee while employed by the Company, or within three months after having
retired with the consent of the Company, and without having fully exercised his
or her Options, the executors or administrators, or legatees or heirs, of his or
her estate shall have the right to exercise such Options to the


<PAGE>


extent that such deceased Participant was entitled to exercise the Options on
the date of his or her death; provided, however, that in no event shall the
Options be exercisable more than ten years from the date they were granted. The
foregoing provisions may be modified or waived by the Board or the Committee and
do not, in any case, apply to any Participant who is not an employee of the
Company. Except for the Options granted pursuant to Independent Directors'
Regular Grants or Independent Directors' Pro Rata Grants, the Board or the
Committee will determine what, if any, provisions concerning exercise of the
Option upon the death of the holder will be included in the Stock Option
Agreement issued to any non-employee.

     8.5 Term of Options. No Option shall expire more than ten years from its
date of grant. Except as otherwise determined by the Board or the Committee when
the Option is granted, an Option granted pursuant to a Discretionary Grant shall
expire as to each tranche of shares five years after the date on which such
Option became exercisable as to such tranche of shares. An Option granted
pursuant to an Independent Director's Regular Grant or an Independent Director's
Pro Rata Grant shall expire five years after the date on which such Option first
became exercisable.

9.   TIME AND MANNER OF OPTION EXERCISE

     Any vested and exercisable Option is exercisable in whole or in part by
giving written notice, signed by the person exercising the Option, to the
Company stating the number of shares with respect to which the Option is being
exercised, accompanied


<PAGE>


by payment in full of the Option Price for the number of shares to be purchased.
The date both such notice and payment are received by the Company shall be the
date of exercise of the Option as to such number of shares. No Option may at any
time be exercised with respect to a fractional share. In the case of exercise in
part only, the Company upon surrender of the Stock Option Agreement, will
deliver to Participant a new Stock Option Agreement in substantially similar
form to that surrendered evidencing the remaining shares as to which the Option
has not been exercised.

10.  PAYMENT OF OPTION PRICE

     Payment of the Option Price may be in cash or by bank-certified, cashier's,
or personal check or, to the extent permitted by the Board or the Committee in
its sole discretion, payment may be in whole or part by:

          (a) transfer to the Company of shares of Common Stock having a fair
     market value equal to the Option Price at the time of such exercise, or

          (b) delivery of instructions to the Company to withhold from the
     shares that would otherwise be issued on exercise that number of shares
     having a fair market value equal to the Option Price at the time of such
     exercise.

     For purposes of the foregoing, the Fair Market Value shall be determined in
accordance with Section 7. If the fair market value of the number of whole
shares transferred or the number of whole shares surrendered in accordance with
the


<PAGE>


foregoing is less than the total Option Price, the shortfall must be paid in
cash.

     In order to comply with all applicable federal or state income tax laws or
regulations, the Company may take such action as it deems appropriate to ensure
that all applicable federal or state payroll , withholding income or other
taxes, which are the sole and absolute responsibility of an optionee or grantee
under the Plan, are withheld or collected from such optionee or grantee.

11.  NONTRANSFERABILITY

     No Option granted under the Plan is transferable other than by will or the
laws of descent and distribution, or pursuant to a qualified domestic relations
order as defined by the Internal Revenue Code of 1986, as amended or Title I of
the Employee Retirement Income Security Act of 1974, as amended or the rules
thereunder, provided, however, that a holder may transfer or assign an Option
granted hereunder to an Immediate Family Member. During the holder's lifetime,
an Option may only be exercised by the holder, an Immediate Family Member upon
transfer to such person or, in the event of his legal incapacity to do so, the
holder's guardian or legal representative. Notwithstanding the foregoing, upon
the holder's death, an Option may be exercised by the executors, administrators,
legatees, or heirs of such Participant's estate.

12.  LIMITATION OF RIGHTS

     Except as provided in this Plan, no employee, director, consultant or
advisor to the Company shall have any claim or right to be granted an Option
under this Plan. Neither the Plan nor


<PAGE>


action thereunder shall be construed as giving an employee, director, consultant
or advisor to the Company any right to be retained in the service of the
Company. No employee, director, consultant or advisor to the Company shall have
any rights as a stockholder with respect to any shares subject to an Option
granted to such employee, director, consultant or advisor to the Company until
the date of issuance of a stock certificate for such shares.

13.  CAPITAL ADJUSTMENTS

     The aggregate number of shares of Common Stock available for Options under
the Plan, the shares subject to any Option, and the price per share, shall all
be proportionately adjusted for any increase or decrease in the number of issued
shares of Common Stock subsequent to the effective date of the Plan resulting
from (1) a subdivision or consolidation of shares or any other capital
adjustment, (2) the payment of a stock dividend on the Company's Common Stock,
or (3) other increase or decrease in such shares effected without receipt of
consideration by the Company. If the Company shall be the surviving corporation
in any merger or consolidation, any Option shall pertain, apply, and relate to
the securities to which a holder of the number of shares of Common Stock subject
to the Option would have been entitled after the merger or consolidation. Upon
dissolution or liquidation of the Company, or upon a merger or consolidation in
which the Company is not the surviving corporation, all Options outstanding
under the Plan shall terminate; provided, however, that each Participant (and
each other person entitled under Section 11 to exercise an


<PAGE>


Option) shall have the right, immediately prior to such dissolution or
liquidation, or such merger or consolidation, to exercise such Participant's
Options in whole or in part, notwithstanding any provisions contained in the
Plan or the Stock Option Agreement, including any vesting requirements to the
contrary.

14.  EFFECTIVE DATE

     The Plan shall be effective as of the date it is initially adopted by the
Board.

15.  RESERVATION OF SHARES OF STOCK

     The Company, during the term of this Plan, will at all times reserve and
keep available, and will seek or obtain from any regulatory body having
jurisdiction any requisite authority necessary to issue and to sell, the number
of shares of Common Stock that shall be sufficient to satisfy the requirements
of this Plan. The inability of the Company to obtain from any regulatory body
having jurisdiction the authority deemed necessary by counsel for the Company
for the lawful issuance and sale of its Common Stock hereunder shall relieve the
Company of any liability in respect of the failure to issue or sell its
securities as to which the requisite authority has not been obtained.

16.  AGREEMENT AND REPRESENTATION OF PARTICIPANTS

     As a condition to the exercise of any portion of an Option, the Company may
require the person exercising such Option to represent and warrant at the time
of such exercise that any shares of Stock acquired at exercise are not
registered under the Securities Act of 1933 (the "Act"), are "restricted
securities" as


<PAGE>


that term is defined in Rule 144 under the Act and are being acquired only for
investment and without any present intention to sell or distribute such shares,
if, in the opinion of counsel for the Company, such a representation is required
under the Act or any other applicable law, regulation, or rule of any
governmental agency.

17.  AMENDMENT AND TERMINATION

     Subject to the last 2 paragraphs of this Section 17, the Board or the
Committee, by resolution, may terminate, amend, or revise the Plan with respect
to any shares as to which Options have not been granted. Neither the Board nor
the Committee may, without the consent of the holder of an Option, alter or
impair any Option previously granted under the Plan, except as authorized
herein. Unless sooner terminated, the Plan shall remain in effect for a period
of ten years from the date of the Plan's initial adoption by the Board.
Termination of the Plan shall not affect any Option previously granted.

     The Plan may be amended by the Board or the Committee as they shall
determine in their discretion from time to time, provided, however, that to the
extent necessary to comply with any applicable law, rule, regulation, stock
exchange listing or Nasdaq or other inclusion requirements to which the Company
is or may become subject to in the future at the time of any such amendment, any
additional authorizations or approvals required to effect such amendment shall
be secured by the Company.

     No amendment shall be made more than once every six months that would
change the amount, price or timing of either the


<PAGE>


Non-Employee Director's Regular Grants or Non-Employee Director's Pro Rata
Grants, other than to comport with changes in the Internal Revenue Code of 1986,
as amended, or the rules and regulations promulgated thereunder.


<PAGE>




Proxy Card


                              Alfacell Corporation

                 Annual Meeting of Stockholders December 9, 1997
           This Proxy Is Solicited on Behalf of the Board of Directors

     Kuslima Shogen and Gail E. Fraser and each of them, as proxies, with full
power of substitution in each of them, are hereby authorized to represent and to
vote, as designated below and on the reverse side, on all proposals and in the
direction of the proxies on such other matters as may properly come before the
annual meeting of stockholders of Alfacell Corporation (the "Company") to be
held on December 9, 1997 or any adjournment(s), postponement(s), or other
delay(s) thereof (the "Annual Meeting"), all shares of stock of the Company to
which the undersigned is entitled to vote at the Annual Meeting.

     UNLESS OTHERWISE DIRECTED, THIS PROXY WILL BE VOTED "FOR" PROPOSALS 1, 2, 3
and 4 AND WILL BE VOTED IN THE DISCRETION OF THE PROXIES ON SUCH OTHER MATTERS
AS MAY PROPERLY COME BEFORE THE ANNUAL MEETING. THE BOARD OF DIRECTORS
RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" PROPOSALS 1, 2, 3 and 4.

(1)  Election of the following nominees as Directors to serve in such capacities
     until their successors are duly elected and qualified:

     Kuslima Shogen             Gail E. Fraser       Stanislaw M. Mikulski, M.D.

     Stephen K. Carter, M.D.    Donald R. Conklin


(Authority to vote for any nominee(s) may be withheld by lining through the
name(s) of any such nominee(s).)


     / / FOR all nominees       / / WITHHOLD authority for all

(2)  Proposal to approve the Company's 1997 Stock Option Plan.

     / / FOR                    / / AGAINST          / / ABSTAIN

(3)  Proposal to amend to Company's Certificate of Incorporation to increase the
     number of authorized shares from twenty five million (25,000,000) to forty
     million (40,000,000).

     / / FOR                    / / AGAINST          / / ABSTAIN


<PAGE>


(4)  Ratification of the selection of KPMG Peat Marwick LLP to audit the
     consolidated financial statements of the Company for the fiscal year ending
     July 31, 1998.

     / / FOR                    / / AGAINST          / / ABSTAIN


/ /  Please check this box if you expect to attend the Annual Meeting in person.


                           (Please sign exactly as name appears to the left,    
                           date and return. If shares are held by joint tenants,
                           both should sign. When signing as attorney, executor,
                           administrator, trustees or guardian, please give full
                           title as such. If a corporation, please sign in full 
                           corporate name by president or other authorized      
                           officer. If a partnership, please sign in partnership
                           name by authorized person.)                          


                           Date: 
                                 ----------------------------------------------


                           -----------------------------------------------------
                                              Sign Here


                           -----------------------------------------------------
                                      Signature (if held jointly)


                           -----------------------------------------------------
                           Capacity (Title or Authority, i.e. Executor, Trustee)


                               PLEASE SIGN, DATE AND MAIL YOUR PROXY TODAY.






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