ALFACELL CORP
SC 13D/A, 2000-04-07
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 (Rule 13d-101)
             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                               (Amendment No. 3)

                              Alfacell Corporation
                                (Name of Issuer)

                            Common Stock and Options
                         (Title of Class of Securities)

                                    015404106
                                 (CUSIP Number)

                                 Kuslima Shogen
                              Alfacell Corporation
                              225 Belleville Avenue
                              Bloomfield, NJ 01003
                                  (973)748-8082
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 March 31, 2000
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e),13d-1(f) or 13d-1(g), check the following box.
[__]


                                  (Page 1 of 5)

<PAGE>


                                   SCHEDULE 13D

CUSIP NO.015404106                                             Page 2 of 5 Pages


1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY)

     Kuslima Shogen
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER                       (a)  [_]
     OF A GROUP                                                  (b)  [_]



________________________________________________________________________________
3.   SEC USE ONLY


________________________________________________________________________________
4.   SOURCE OF FUNDS

     Not Applicable
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL
     PROCEEDINGS IS REQUIRED PURSUANT                            [X]
     TO ITEMS 2(d) OR 2(e)

________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION

     United States
________________________________________________________________________________
               7.   SOLE VOTING POWER

                    2,376,343  (includes  1,127,723  shares  subject  to options
                    which  are  currently   exercisable  or  which  will  become
                    exercisable within 60 days of March 31, 2000).
NUMBER OF SHARES
BENEFICIALLY   _________________________________________________________________
OWNED          8.   SHARED VOTING POWER
BY EACH
REPORTING           0
PERSON WITH    _________________________________________________________________
               9.   SOLE DISPOSITIVE POWER

                    2,376,343  (includes  1,127,723  shares  subject  to options
                    which  are  currently   exercisable  or  which  will  become
                    exercisable within 60 days of March 31, 2000).
              _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER

                    0
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY
     OWNED BY EACH REPORTING PERSON

     2,376,343 (includes 1,127,723 shares subject to options which are currently
     exercisable  or which will become  exercisable  within 60 days of March 31,
     2000).
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT                           [_]
     IN ROW (11) EXCLUDES CERTAIN
     SHARES

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY
     AMOUNT IN ROW (11)

     12.2%

________________________________________________________________________________
14.  TYPE OF REPORTING PERSON

     IN

________________________________________________________________________________


<PAGE>


                                                               Page 3 of 5 pages

Item 1.  Security and Issuer

     The  securities to which this Schedule 13D relates are the shares of common
stock, par value $.001 per share (the "Common Stock"),  of Alfacell  Corporation
(the "Issuer").  The address of the Issuer's principal  executive offices is 225
Belleville Avenue, Bloomfield, NJ 07003

Item 2.  Identity and Background

     (a) - (c) The person (the  "Reporting  Person")  filing this  statement  is
Kuslima Shogen, Chief Executive Officer and Chairman of the Board of the Issuer.
The  Reporting  Person's  mailing  address  is  c/o  Alfacell  Corporation,  225
Belleville Avenue, Bloomfield, NJ 07003.

     (d) During the last five years, the Reporting Person has not been convicted
in a criminal proceeding (excluding traffic violations or similar misdemeanors).

     (e) The Reporting  Person  entered a consent decree with the Securities and
Exchange  Commission  ("SEC") on March 4, 1998  pursuant  to which she was fined
$20,000  for  alleged  violations  of  Sections  13 and 16(a) of the  Securities
Exchange  Act of 1934,  as  amended.  In  connection  with the  settlement,  the
Reporting  Person  neither  admitted nor denied the  allegations  of the SEC and
agreed not to violate Sections 13 and 16(a) in the future.

     (f) The Reporting Person is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration

     Not Applicable

Item 4.  Purpose of the Transaction

     The Reporting Person previously  acquired options to purchase Common Stock.
In October 1999, an additional  23,000 options became  exercisable.  As of March
31, 2000, 327,242 of the then currently exercisable options expired resulting in
a decrease to the Reporting Person's beneficial ownership.

Item 5.  Interest in Securities of the Issuer

     (a) The  Reporting  Person  beneficially  owns  2,376,343  shares of Common
Stock,  consisting of 1,248,620 shares of Common Stock currently outstanding and
1,127,723  shares  underlying  options  to  purchase  Common  Stock  held by the
Reporting  Person.  Such shares constitute 12.2% of the Common Stock outstanding
assuming all of the options are exercised.

     (b) The  Reporting  Person has the sole power to vote or to direct the vote
and the sole power to dispose or direct the  disposition of the shares of Common
Stock.

     (c) None.


<PAGE>


                                                               Page 4 of 5 pages

     (d)  The  Reporting  Person  has  pledged  a  total  of  1,023,000  of  the
outstanding  shares of Common Stock to First Union National Bank (the "Bank") to
secure a personal loan.  Upon the sale of the shares of Common Stock held by the
Reporting Person,  the Bank has the right to apply such proceeds thereof to such
loan.

     (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
Securities of the Issuer

     Not Applicable

Item 7.  Material to be Filed as Exhibits

     Not Applicable


<PAGE>


                                                               Page 5 of 5 pages

                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Date: April 6, 2000

                                                     By: /s/ KUSLIMA SHOGEN
                                                         -----------------------
                                                         Kuslima Shogen
                                                         Chief Executive Officer




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