CENTOCOR INC
424B3, 1994-03-03
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>
 
   
SUPPLEMENT TO PROSPECTUS DATED FEBRUARY 2, 1994     
 
                                 CENTOCOR, INC.
 
                     EXCHANGE OFFER TO HOLDERS OF UNITS,
                EACH UNIT CONSISTING OF ONE SHARE OF CALLABLE
            COMMON STOCK OF TOCOR II, INC., ONE SERIES T WARRANT
            TO PURCHASE ONE SHARE OF CENTOCOR, INC. COMMON STOCK
               AND ONE CALLABLE WARRANT TO PURCHASE ONE SHARE
                       OF CENTOCOR, INC. COMMON STOCK
   
  This Supplement (the "Supplement") supplements the Prospectus dated February
2, 1994 (the "Prospectus") relating to the Exchange Offer to Holders of Units,
each Unit consisting of one share of Callable Common Stock of Tocor II, Inc.,
one Series T Warrant to Purchase One Share of Centocor, Inc. Common Stock and
one Callable Warrant to Purchase One Share of Centocor, Inc. Common Stock.
Unless otherwise defined herein, capitalized terms used herein have the same
meanings as in the Prospectus. Except as set forth herein, the terms and
conditions of the Exchange Offer remain as set forth in the Prospectus.     
   
  Centocor, Inc. publicly announced on March 1, 1994 that the prognosis for
Chairman Hubert J.P. Schoemaker, following recent, successful surgery to remove
a brain tumor, promising. Dr. Schoemaker continues to function as Chairman
of the Board of Centocor. Annex A to this Supplement sets forth the related
press release of Centocor, Inc. dated March 1, 1994.     
   
  Centocor, Inc. has extended the Expiration Date to 5:00 p.m., New York City
time, on March 11, 1994.     
   
  Questions and requests for assistance or for additional copies of this
Supplement may be directed to Centocor, Inc. at its address set forth on page 4
of the Prospectus or to D. F. King & Co., Inc. at its address set forth on the
back cover of the Prospectus. Additional copies of this Supplement may also be
obtained from brokers, dealers, commercial banks, trust companies and other
nominees.     
        
 
     
  Holders should continue to use the  Letter of Transmittal that was provided
    with the  Prospectus, notwithstanding  that such Letter  of Transmittal
      indicates that  the Expiration  Date  is 5:00  p.m., New  York City
        time, on March 4, 1994, unless the Offer is extended.     
   
  To be properly tendered pursuant to the Exchange Offer, Units, together with
a properly completed and executed Letter of Transmittal and any other documents
required by the Letter of Transmittal, must be received by the Depositary at
its address set forth below prior to the Expiration Date.     
                               
                            The Depositary is:     
                        
                     The First National Bank of Boston     
                             
                          Blue Hills Office Park     
                                
                             150 Royall Street     
                                
                             Canton, MA 02021     
         
    
 THESE SECURITIES HAVE NOT BEEN APPROVED  OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION  OR  ANY  STATE SECURITIES  COMMISSION,  NOR  HAS THE
    COMMISSION OR ANY STATE SECURITIES  COMMISSION PASSED UPON THE ACCURACY
      OR ADEQUACY OF THIS SUPPLEMENT.  ANY REPRESENTATION TO THE CONTRARY
       IS A CRIMINAL OFFENSE.     
   
THE EXCHANGE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 5:00 P.M., NEW YORK
CITY TIME, ON MARCH 11, 1994, UNLESS EXTENDED.     
                     
                  THIS SUPPLEMENT IS DATED MARCH 2, 1994.     


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