<PAGE>
FILED UNDER RULE 424(b)(3) OF REGULATION C
SEC FILE NUMBER: 333-53157
PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JULY 2, 1998)
CENTOCOR, INC.
$460,000,000 PRINCIPAL AMOUNT OF 4 3/4% CONVERTIBLE
SUBORDINATED DEBENTURES DUE 2005
(INTEREST PAYABLE AUGUST 15 AND FEBRUARY 15)
-------------------------------------
9,338,015 COMMON SHARES
($.01 PAR VALUE PER SHARE)
------------------------
The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statement set forth under the caption "Selling
Securityholders" in the Prospectus, as supplemented on July 9, 1998.
Capitalized terms used and not defined herein shall have the meanings given to
them in the Prospectus.
SELLING SECURITYHOLDERS
The information set forth under the caption "Selling Securityholders" in
the Prospectus, as supplemented on July 9, 1998, is supplemented to add the
following:
<TABLE>
<CAPTION>
NUMBER OF
CONVERSION
NAME OF SELLING AMOUNT OF DEBENTURES PERCENT OF SHARES THAT
SECURITYHOLDER(1) BENEFICIALLY OWNED OUTSTANDING DEBENTURES MAY BE SOLD(2)
- ---------------------- -------------------- ---------------------- --------------
<S> <C> <C> <C>
Marie Daly Banks
Trust $ 20,000 .004 406
Mary Chapin
Carpenter $ 15,000 .003 304
Eileen M. Connell
(IRA) $ 20,000 .004 406
Corbel Investments $ 100,000 .02 2,030
DeLozier, Joseph
& Jan $ 10,000 .002 203
Equity Commonwealth $ 30,000 .006 609
Levin Charitable
Trust $ 15,000 .003 304
Jack C. Massey
Foundation $ 40,000 .008 812
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
<S> <C> <C> <C>
J.P. Morgan
Securities
Incorporated $8,370,000 1.82 169,911
Mary Ann McCready $ 20,000 .004 406
Paloma Securities
L.L.C. $ 600,000 .13 12,180
Sanders, Mark &
Cynthia $ 20,000 .004 406
Silverton
International
Fund Limited $3,000,000 .65 60,900
Thomas Engineering,
Inc. $ 40,000 .008 812
Zazove Aggressive
Growth Fund, L.P. $ 245,000 .05 4,973
Zazove Global
Convertible Fund,
L.P. $ 75,000 .02 1,522
</TABLE>
____________________________
(1) The information set forth herein is as of July 16, 1998 and will be updated
as required.
(2) Assumes conversion of the full amount of Debentures held by such holder at
the initial conversion price of $49.261 per share of Common Stock. Under
the terms of the Indenture, fractional shares will not be issued upon
conversion of the Debentures; cash will be paid in lieu of any fractional
shares.
The date of this Prospectus Supplement is July 16, 1998.
