<PAGE>
FILED UNDER RULE 424(b)(3) OF REGULATION C
SEC FILE NUMBER: 333-53157
PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JULY 2, 1998)
CENTOCOR, INC.
$460,000,000 PRINCIPAL AMOUNT OF 4 3/4% CONVERTIBLE
SUBORDINATED DEBENTURES DUE 2005
(INTEREST PAYABLE AUGUST 15 AND FEBRUARY 15)
-------------------------------------
9,338,015 COMMON SHARES
($.01 PAR VALUE PER SHARE)
------------------------
The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statement set forth under the caption "Selling
Securityholders" in the Prospectus, as supplemented on July 9, 1998, July 16,
1998, July 29, 1998, August 4, 1998, August 11, 1998, August 18, 1998, August
24, 1998, September 1, 1998, September 3, 1998, September 15, 1998, September
21, 1998, September 24, 1998 and October 1, 1998. Capitalized terms used and
not defined herein shall have the meanings given to them in the Prospectus.
SELLING SECURITYHOLDERS
The information set forth under the caption "Selling Securityholders" in
the Prospectus, as supplemented on July 9, 1998, July 16, 1998, July 29, 1998,
August 4, 1998, August 11, 1998, August 18, 1998, August 24, 1998, September 1,
1998, September 3, 1998, September 15, 1998, September 21, 1998, September 24,
1998, and October 1, 1998, is supplemented to add the following:
<TABLE>
<CAPTION>
NUMBER OF
CONVERSION
NAME OF SELLING AMOUNT OF DEBENTURES PERCENT OF SHARES THAT
SECURITYHOLDER(1) BENEFICIALLY OWNED OUTSTANDING DEBENTURES MAY BE SOLD(2)
- -------------------- -------------------- ----------------------- --------------
<S> <C> <C> <C>
Argent Classic
Convertible
Arbitrage
Fund L.P. $15,500,000 3.37% 314,650
Argent Classic
Convertible
Arbitrage Fund
(Bermuda) L.P. $25,000,000 5.43% 507,500
Argent Offshore
Fund, L.P. $ 5,000,000 1.08% 101,500
Boston College $ 113,000 .02% 2,293
Employers'
Reinsurance
Corporation $ 578,000 .12% 11,733
General Motors
Employees
Domestic
Group Pension
Trust $ 1,000,000 .22% 20,300
Hull
Overseas, Ltd. $ 100,000 .02% 2,030
</TABLE>
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<TABLE>
<S> <C> <C> <C>
J.M. Hull
Associates, L.P. $ 500,000 .11% 10,150
JP Morgan
Securities
Incorporated $5,000,000 1.09% 101,500
New Hampshire
Retirement
System $ 614,000 .13% 12,464
Parker-Hannifin
Corporation $ 185,000 .04% 3,755
ProMutual $ 516,000 .11% 10,474
Putnam
Balanced
Retirement
Fund $ 313,000 .07% 6,353
Putnam
Convertible
Income-Growth
Trust $5,000,000 1.08% 101,500
Putnam
Convertible
Opportunities
and Income
Trust $ 385,000 .08% 7,815
Putnam Funds
Trust - Putnam
High Yield
Total
Return Fund $ 44,000 .009% 893
Rhone-Poulenc
Rorer
Pension Plan $ 195,000 .04% 3,958
University
of Rochester $ 119,000 .02% 2,415
</TABLE>
_______________
(1) The information set forth herein is as of October 13, 1998 and will be
updated as required.
(2) Assumes conversion of the full amount of Debentures held by such holder at
the initial conversion price of $49.261 per share of Common Stock. Under
the terms of the Indenture, fractional shares will not be issued upon
conversion of the Debentures; cash will be paid in lieu of any fractional
shares.
The date of this Prospectus Supplement is October 13, 1998.
