CENTOCOR INC
SC 13G, 1999-04-26
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                              UNITED STATES
                    SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549

                                SCHEDULE 13G

                 Under the Securities Exchange Act of 1934
                          (Amendment No.       )*
                                         ------

                               CENTOCOR INC.
- --------------------------------------------------------------------------------
                              (Name of Issuer)

                                   COMMON
- --------------------------------------------------------------------------------
                       (Title of Class of Securities)

                                152342101
                     ----------------------------------
                              (CUSIP Number)


- --------------------------------------------------------------------------------
               (Date of Event Which Requires Filing of this Statement)

Check the following box if a fee is being paid with this statement / /. (A 
fee is not required only if the filing person: (1) has a previous statement 
on file reporting beneficial ownership of more than five percent of the class 
of securities described in Item 1; and (2) has filed no amendment subsequent 
thereto reporting beneficial ownership of five percent or less of such 
class.) (See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which 
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not 
be deemed to be "filed" for the purpose of Section 18 of the Securities 
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that 
section of the Act but shall be subject to all other provisions of the Act 
(however, see the Notes).

                               Page 1 of 3 Pages

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CUSIP No. 152342101                  13G                      Page 2 of 3 Pages

- -------------------------------------------------------------------------------
 (1) Names of Reporting Persons
     S.S. or I.R.S. Identification No. of above person.

     PRIMECAP Management Company    95-3868081
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member   (a)  / /
     of a Group* (See Instructions)           (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization

     225 So. Lake Avenue #400, Pasadena, CA 91101
- -------------------------------------------------------------------------------
 Number of Shares             (5) Sole Voting Power
 Beneficially                     931,900
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                      -0-
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  931,900
                             --------------------------------------------------
                              (8) Shared Dispositive Power
                                  2,699,200
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person

     3,631,100
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*
        / /
- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row 9

     5.14%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*

     IA
- -------------------------------------------------------------------------------
                     * SEE INSTRUCTION BEFORE FILLING OUT!
                               Page 2 of 3 Pages

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    (c) Number of shares as to which the person has:

          (i) Sole power to vote or to direct the vote
         (ii) Shared power to vote or to direct the vote
        (iii) Sole power to dispose or to direct the disposition of
         (iv) Shared power to dispose or to direct the disposition of

INSTRUCTION: For computations regarding securities which represent a right to 
             acquire an underlying security see Rule 13d-3(d)(1).

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

    If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following.  / /

INSTRUCTION: Dissolution of a group requires a response to this item.

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

     If any other person is known to have the right to receive or the power 
to direct the receipt of dividends from, or the proceeds from the sale of, 
such securities, a statement to that effect should be included in response 
to this item and, if such interest relates to more than five percent of the 
class, such person should be identified. A listing of the shareholders of an 
investment company registered under the Investment Company act of 1940 or the 
beneficiaries of employee benefit plan, pension fund or endowment fund is not 
required.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
         THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

     If a parent holding company has filed this schedule, pursuant to Rule 
13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating 
the identity and the Item 3 classification of the relevant subsidiary. If a 
parent holding company has filed this schedule pursuant to Rule 13d-1(c), 
attach an exhibit stating the identification of the relevant subsidiary.

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

     If a group has filed this schedule pursuant to Rule 13d-1(b)(ii)(H), 
so indicate under Item 3(h) and attach an exhibit stating the identity and 
Item 3 classification of each member of the group. If a group has filed this 
schedule pursuant to Rule 13d-1(c), attach an exhibit stating the identity of 
each member of the group.

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

     Notice of dissolution of a group may be furnished as an exhibit stating 
the date of the dissolution and that all further filings with respect to 
transactions in the security reported on will be filed, if required, by 
members of the group, in their individual capacity. See Item 5.

ITEM 10.  CERTIFICATION

     The following certification shall be included if the statement is filed 
pursuant to Rule 13d-1(b):

     By signing below I certify that, to the best of my knowledge and belief, 
the securities referred to above were acquired in the ordinary course of 
business and were not acquired for the purpose of and do not have the effect 
of changing or influencing the control of the issuer of such securities and 
were not acquired in connection with or as a participant in any transaction 
having such purposes or effect.

                                  SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                                    March 31, 1999
                                       ----------------------------------------
                                                         Date

                                              /s/ THEO A. KOLOKOTRONES
                                       ----------------------------------------
                                                      Signature

                                           Theo A. Kolokotrones, President
                                       ----------------------------------------
                                                      Name/Title


                               Page 3 of 3 Pages


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