CENTOCOR INC
424B3, 2000-08-16
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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Prospectus Supplement                         Filed Pursuant to Rule 424(b)(3)
(To Prospectus dated July 2, 1998)                  Registration No. 333-53157



                                Centocor, Inc.

                                 $460,000,000

              4 3/4% Convertible Subordinated Debentures due 2005

                 (Interest Payable August 15 and February 15)

          This prospectus supplement contains information about the persons
who can use this prospectus supplement to offer and sell Centocor debentures
those persons own.

                           SELLING SECURITYHOLDERS

          The information set forth in the table under the caption "Selling
Securityholders" in the Centocor prospectus dated July 2, 1998, relating to
Centocor's 4 3/4% Convertible Subordinated Debentures due 2005, as
supplemented on July 9, 16 and 29, 1998, August 4, 11, 18 and 24, 1998,
September 1, 3, 15, 21 and 24, 1998, October 1, 13, 14 and 20, 1998, November
9, 12, 16, 20 and 30, 1998, December 3, 17, and 29, 1998, January 4 and 6,
1999, February 17, 1999, March 3, 11, 16, 22 and 25, 1999, April 26 and 30,
1999, May 17 and 26, 1999, June 15, 1999, July 28 and 30, 1999, August 17 and
20, 1999, September 9 and 29, 1999, December 29, 1999, March 31, 2000, April
17, 2000, May 5, 2000 and August 1, 2000, is supplemented to add the
following:

                          Principal                               Principal
                          Amount            Percentage of          Amount
     Name of Selling     Beneficially        Outstanding       Registered for
    Securityholder (1)     Owned($)      Centocor Debentures   Sale Hereby($)

     Thomas L. Rinker      20,000                 *                 20,000


---------------

(1)      The information set forth herein is as of August 16, 2000.


   * Represents beneficial ownership of less than 1% of the aggregate
principal amount of Centocor debentures outstanding as of August 16, 2000.

                The date of this prospectus is August 16, 2000.




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