ALZA TTS RESEARCH PARTNERS LTD
SC 14D1, 1997-11-20
PHARMACEUTICAL PREPARATIONS
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- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
 
                            ------------------------
 
                                 SCHEDULE 14D-1
 
              TENDER OFFER STATEMENT PURSUANT TO SECTION 14(D)(1)
 
                     OF THE SECURITIES EXCHANGE ACT OF 1934
 
                        ALZA TTS RESEARCH PARTNERS, LTD.
 
                           (Name of subject company)
                              PHARMAINVEST, L.L.C.
                        PHARMACEUTICAL ROYALTIES, L.L.C.
                    PHARMACEUTICAL ROYALTY INVESTMENTS LTD.
                        PHARMACEUTICAL PARTNERS, L.L.C.
                                    (Bidder)
 
                     UNITS OF LIMITED PARTNERSHIP INTEREST
                         (Title of class of securities)
 
                                      NONE
                                 (CUSIP Number)
 
                            ------------------------
 
                          PABLO LEGORRETA, DAVE MADDEN
                              PHARMAINVEST, L.L.C.
                           70 E. 55th St., 23rd Floor
                               New York, NY 10022
                                 (800) 600-1450
 
                            ------------------------
 
                                   COPIES TO:
                             F. GEORGE DAVITT, ESQ.
                        TESTA, HURWITZ & THIBEAULT, LLP
                               HIGH STREET TOWER
                                125 HIGH STREET
                                BOSTON, MA 02110
 
                            ------------------------
 
                           CALCULATION OF FILING FEE
 
<TABLE>
<S>                                                              <C>
                    TRANSACTION VALUATION*                                            AMOUNT OF FILING FEE
                          $16,800,000                                                        $3,360
</TABLE>
 
*   Estimated for purposes of calculating the amount of the filing fee only. The
    amount assumes the purchase of 1,400 units of limited partnership interest
    (the "Units") of the subject company at $12,000 per Unit in cash.
 
/ /  Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
    and identify the filing with which the offsetting fee was previously paid.
    Identify the previous filing by registration statement number, or the form
    or schedule and the date of its filing.
 
<TABLE>
<S>                                               <C>
        Amount Previously Filing Paid: None       Filing Party: Not applicable
        Form or Registration No: Not              Date filed: Not applicable
        Applicable
</TABLE>
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
    This Tender Offer Statement on Schedule 14D-1 is filed by PharmaInvest,
L.L.C., a Delaware limited liability company (the "Purchaser") on behalf of
Pharmaceutical Royalties, L.L.C., a Delaware limited liability company, and
Pharmaceutical Royalty Investments Ltd., a Bermuda company (collectively the
"Funds"), and on behalf of Pharmaceutical Partners, L.L.C., relating to the
offer by Purchaser to purchase outstanding Units of Limited Partnership Interest
(the "Units"), of ALZA TTS Research Partners, Ltd. (the "Partnership"), a
California limited partnership, at $12,000 per Unit, net to the seller in cash,
on the terms and subject to the conditions set forth in the Offer to Purchase,
dated November 20, 1997 (the "Offer to Purchase"), and in the related Letter of
Transmittal and any amendments or supplements thereto, copies of which are
attached hereto as Exhibits (a)(1) and (a)(2), respectively (which collectively
constitute the "Offer").
 
ITEM 1. SECURITY AND SUBJECT COMPANY
 
    (a) The name of the subject company is ALZA TTS Research Partners, Ltd., a
California limited partnership. The address of the Partnership's principal
executive office is 950 Page Mill Road, P. O. Box 10950, Palo Alto, CA,
94303-0802.
 
    (b) The information set forth on the cover page and under "Introduction" in
the Offer to Purchase is incorporated herein by reference.
 
    (c) The information set forth in Section 6 of the Offer to Purchase is
incorporated herein by reference.
 
ITEM 2. IDENTITY AND BACKGROUND
 
    (a)-(d), (g) This Statement is filed by the Purchaser and the Funds. The
information set forth on the cover page, under "Introduction," in Section 9, and
in Schedule I of the Offer to Purchase is incorporated herein by reference.
 
    (e)-(f) During the last five years, neither Purchaser, the Funds or, to
their knowledge, any of the persons listed in Schedule I to the Offer to
Purchase, (i) has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors) or (ii) has been a party to a civil
proceeding of a judicial or administrative body of competent jurisdiction and as
a result of such proceeding was or is subject to a judgment, decree or final
order enjoining future violations of, or prohibiting activities subject to,
federal or state securities laws or finding any violation of such laws.
 
ITEM 3. PAST CONTACTS, TRANSACTIONS, OR NEGOTIATIONS WITH THE SUBJECT COMPANY
 
    (a) The information set forth in Section 11 of the Offer to Purchase is
incorporated herein by reference.
 
    (b) The information set forth under "Introduction" and in Sections 9, 11 and
12 of the Offer to Purchase is incorporated herein by reference.
 
ITEM 4. SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION
 
    (a) The information set forth in Section 10 of the Offer to Purchase is
incorporated herein by reference.
 
    (b)-(c) Not applicable.
 
ITEM 5. PURPOSE OF THE TENDER OFFER AND PLANS OR PROPOSALS OF THE BIDDER
 
    (a)-(e) The information set forth in Section 12 of the Offer to Purchase is
incorporated herein by reference.
 
    (f)-(g) The information set forth in Section 7 of the Offer to Purchase is
incorporated herein by reference.
<PAGE>
ITEM 6. INTEREST IN SECURITIES OF THE SUBJECT COMPANY
 
    (a)-(b) The information set forth under "Introduction" and in Sections 9, 11
and 12 of the Offer to Purchase is incorporated herein by reference.
 
ITEM 7. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO
  THE SUBJECT COMPANY'S SECURITIES
 
    The information set forth under "Introduction" and in Sections 9, 11 and 12
of the Offer to Purchase is incorporated herein by reference.
 
ITEM 8. PERSONS RETAINED, EMPLOYED OR TO BE COMPENSATED
 
    The information set forth under "Introduction" and in Section 16 of the
Offer to Purchase is incorporated herein by reference.
 
ITEM 9. FINANCIAL STATEMENTS OF CERTAIN BIDDERS
 
    Not applicable.
 
ITEM 10. ADDITIONAL INFORMATION
 
    (a) The information set forth under "Introduction" and in Sections 11 and 12
of the Offer to Purchase is incorporated herein by reference.
 
    (b)(c) and (e) The information set forth in Section 15 of the Offer to
Purchase is incorporated herein by reference.
 
    (d) The information set forth in Section 7 of the Offer to Purchase is
incorporated herein by reference.
 
    (f) The information set forth in the Offer to Purchase and the Letter of
Transmittal, copies of which are attached hereto as Exhibits (a)(1) and (a)(2),
respectively, is incorporated herein by reference.
 
ITEM 11. MATERIAL TO BE FILED AS EXHIBITS
 
    (a)(1) Offer to Purchase dated November 20, 1997.
 
    (a)(2) Letter of Transmittal and Instructions.
 
    (a)(3) Cover letter from PharmaInvest, L.L.C.
 
    (b)(c)(d) None.
 
    (e) Not applicable.
 
    (f) None.
 
                                       2
<PAGE>
                                   SIGNATURES
 
    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
 
Dated: November 20, 1997
 
                                          PHARMAINVEST, L.L.C.
 
                                          By: /s/_Pablo Legorreta_______________
 
                                          Title: Managing Member of
                                          __Pharmaceutical Partners, L.L.C., the
                                          Manager__
 
                                          PHARMACEUTICAL ROYALTIES, L.L.C.
 
                                          By:_/s/_Pablo Legorreta_______________
 
                                          Title: Managing Member of
                                          __Pharmaceutical Partners, L.L.C., the
                                          Manager__
 
                                          PHARMACEUTICAL ROYALTY
                                          INVESTMENTS LTD.
 
                                          By:_/s/_Pablo Legorreta_______________
 
                                          Title: Managing Member of
                                          __Pharmaceutical Partners, L.L.C., the
                                          Manager__
 
                                          PHARMACEUTICAL PARTNERS, L.L.C.
 
                                          By:_/s/_Pablo Legorreta_______________
 
                                          Title: Managing Member________________
 
                                       3
<PAGE>
                                 EXHIBIT INDEX
 
<TABLE>
<CAPTION>
 EXHIBIT                                                  DESCRIPTION
- ---------  ---------------------------------------------------------------------------------------------------------
<S>        <C>
(a)(1)     Offer to Purchase dated November 20, 1997
(a)(2)     Letter of Transmittal and Instructions
(a)(3)     Cover letter from PharmaInvest, L.L.C.
</TABLE>
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                      [THIS PAGE LEFT BLANK INTENTIONALLY]

<PAGE>
                           OFFER TO PURCHASE FOR CASH
         UP TO 1,400 OUTSTANDING UNITS OF LIMITED PARTNERSHIP INTEREST
                                       OF
                        ALZA TTS RESEARCH PARTNERS, LTD.
                                       AT
                              $12,000 NET PER UNIT
                                       BY
                              PHARMAINVEST, L.L.C.
                                 --------------
 
PharmaInvest, L.L.C., a Delaware limited liability company (the "Purchaser") on
behalf of Pharmaceutical Royalties, L.L.C., a Delaware limited liability
company, and Pharmaceutical Royalty Investments Ltd., a Bermuda company
(collectively the "Funds"), and on behalf of Pharmaceutical Partners, L.L.C.,
hereby offers to purchase up to 1,400 outstanding units of limited partnership
interest (the "Units") in ALZA TTS Research Partners, Ltd., a California limited
partnership (the "Partnership"), for cash consideration per Unit of $12,000 (the
"Purchase Price") upon the terms and subject to the conditions set forth in this
Offer to Purchase and the related Letter of Transmittal (which, together with
any amendments or supplements hereto or thereto, collectively constitute the
"Offer"). The Purchase Price will be automatically reduced by the aggregate
amount of the value of any cash or asset distributions made or declared by the
Partnership on or after December 31, 1997 and prior to the date on which the
Purchaser pays the Purchase Price for the tendered Units. This Offer is made to
all beneficial owners of Units (each a "Holder").
 
                                  RISK FACTORS
 
- -  Although the Purchaser cannot predict the future value of the Partnership's
    assets or future selling prices of the Units, the Purchase Price could
    differ significantly from the proceeds that would be realized by holding the
    Units for the entire life of the expected payment stream of the
    Partnership's assets.
 
- -  The Purchaser is making the Offer with a view to making a profit.
    Accordingly, there may be a conflict between the desire of the Purchaser to
    acquire the Units at the Purchase Price and the value of the expected
    payment stream of the Partnership's assets. There can be no assurance that
    the Purchase Price will be more or less than such value.
 
- -  No independent person has been retained by the Purchaser or any of its
    affiliates to value or make any appraisal of the Units or to render any
    opinion with respect to the fairness of the Purchase Price and no
    representation is made with respect to the fairness of the Purchase Price.
 
- -  Although there are limited resale mechanisms available to Holders through
    partnership matching services, there is no formal trading market for the
    Units. The Offer provides each Holder the opportunity to liquidate his or
    her investment in the Partnership without transfer fees and transaction
    costs generally incurred in secondary market sales (which can range from 5%
    to 8.75% of the sale price).
                              -------------------
 
         THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT,
     NEW YORK CITY TIME ON DECEMBER 19, 1997, UNLESS THE OFFER IS EXTENDED.
 
                              -------------------
 
AS OF THE DATE OF THIS OFFER, THE GENERAL PARTNER OF THE PARTNERSHIP, ALZA
DEVELOPMENT CORPORATION, HAS NOT MADE ANY RECOMMENDATION TO ANY HOLDER AS TO
WHETHER TO TENDER OR REFRAIN FROM TENDERING HIS OR HER UNITS. NO LATER THAN 10
BUSINESS DAYS FROM THE DATE OF THIS OFFER, THE GENERAL PARTNER IS REQUIRED BY
LAW TO ISSUE A STATEMENT THAT (I) THE PARTNERSHIP ACCEPTS OR REJECTS THE OFFER,
(II) THE PARTNERSHIP EXPRESSES NO OPINION AND IS REMAINING
<PAGE>
NEUTRAL TOWARD THE OFFER OR (III) THE PARTNERSHIP IS UNABLE TO TAKE A POSITION
WITH RESPECT TO THE OFFER.
                              -------------------
 
THE OFFER IS CONDITIONED UPON, AMONG OTHER THINGS, PURCHASER BEING SATISFIED,
PRIOR TO THE EXPIRATION DATE, IN ITS REASONABLE DISCRETION, THAT, UPON PURCHASE
OF THE UNITS PURSUANT TO THE OFFER, IT, THE FUNDS AND/OR THEIR NOMINEE WILL HAVE
FULL RIGHTS TO OWNERSHIP AS TO ALL SUCH UNITS AND THAT THE GENERAL PARTNER WILL
CONSENT TO IT, THE FUNDS OR THEIR NOMINEE BECOMING ASSIGNEES OF THE PURCHASED
UNITS AND A SUBSTITUTE LIMITED PARTNER WITH RESPECT TO ALL SUCH UNITS. THE OFFER
IS ALSO SUBJECT TO CERTAIN OTHER CONDITIONS CONTAINED IN THIS OFFER TO PURCHASE.
SEE SECTIONS 2 AND 14.
 
EACH HOLDER IS URGED TO READ CAREFULLY THE ENTIRE OFFER TO PURCHASE, THE LETTER
OF TRANSMITTAL AND RELATED DOCUMENTS.
 
                                       2
<PAGE>
                                 --------------
 
                                   IMPORTANT
 
    Any Holder wishing to tender all or a portion of his or her Units should
complete and sign the Letter of Transmittal in accordance with the Instructions
attached to the Letter of Transmittal, mail or deliver it and any other required
documents to the Depositary at its address set forth on the back cover of this
Offer to Purchase and tender those Units pursuant to the procedures for transfer
set forth in Section 3 hereof and the Instructions attached to the Letter of
Transmittal.
 
    There is no established trading market for the Units.The Purchase Price has
been established by the Purchaser, in its sole discretion. No independent
opinion, report or appraisal related to the valuation of the Units has been
obtained by the Purchaser.
 
    Questions and requests for assistance may be directed to the Information
Agent or the Purchaser at their respective addresses and telephone numbers set
forth in the Instructions attached to the Letter of Transmittal and on the back
cover of this Offer to Purchase. Requests for additional copies of this Offer to
Purchase, the Letter of Transmittal and other related materials may be directed
to the Information Agent or the Purchaser.
 
                                 --------------
 
                                       3
<PAGE>
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                                                                                    PAGE
                                                                                                                 -----------
<C>        <S>                                                                                                   <C>
 
INTRODUCTION...................................................................................................           5
       1.  TERMS OF THE OFFER..................................................................................           7
       2.  PRORATION; ACCEPTANCE FOR PAYMENT AND PAYMENT.......................................................           8
       3.  PROCEDURE FOR TENDERING UNITS.......................................................................           9
       4.  WITHDRAWAL RIGHTS...................................................................................          10
       5.  CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE OFFER................................................          10
       6.  PRICE RANGE OF THE UNITS............................................................................          13
       7.  EFFECT OF THE OFFER ON EXCHANGE ACT REGISTRATION....................................................          13
       8.  CERTAIN INFORMATION CONCERNING THE PARTNERSHIP......................................................          14
       9.  CERTAIN INFORMATION CONCERNING PURCHASER............................................................          17
      10.  SOURCE AND AMOUNT OF FUNDS..........................................................................          18
      11.  BACKGROUND OF THE OFFER.............................................................................          18
      12.  PURPOSE OF THE OFFER; PLANS FOR THE PARTNERSHIP.....................................................          19
      13.  DISTRIBUTIONS TO LIMITED PARTNERS...................................................................          19
      14.  CERTAIN CONDITIONS OF THE OFFER.....................................................................          19
      15.  CERTAIN LEGAL MATTERS...............................................................................          21
      16.  FEES AND EXPENSES...................................................................................          22
      17.  MISCELLANEOUS.......................................................................................          22
SCHEDULE I.....................................................................................................         A-1
</TABLE>
 
                                       4
<PAGE>
To Holders of Units of Limited Partnership Interest in ALZA TTS Research
Partners, Ltd.:
 
                                  INTRODUCTION
 
    PharmaInvest, L.L.C., a Delaware limited liability company (the "Purchaser")
on behalf of Pharmaceutical Royalties, L.L.C., a Delaware limited liability
company, and Pharmaceutical Royalty Investments Ltd., a Bermuda company
(collectively the "Funds"), and on behalf of Pharmaceutical Partners, L.L.C.,
hereby offers to purchase up to 1,400 units of limited partnership interest (the
"Units") in ALZA TTS Research Partners, Ltd., a Delaware limited partnership
(the "Partnership"), for cash consideration per Unit of $12,000 (the "Purchase
Price"), upon the terms and subject to the conditions set forth in this Offer to
Purchase and the related Letter of Transmittal (which, together with any
amendments or supplements hereto or thereto, collectively constitute the
"Offer"). The Purchase Price will be automatically reduced by the aggregate
amount of any cash or asset distributions made or declared by the Partnership or
after December 31, 1997 and prior to the date on which the Purchaser pays the
Purchase Price for the tendered Units. This Offer is made to all beneficial
owners of Units (each a "Holder").
 
    The Purchaser and the Funds are making this Offer because the Funds believe
that the Units represent an attractive investment at the price offered. There
can be no assurance, however, that this belief is correct and, as a result,
ownership of Units (either by the Purchaser, the Funds or Holders who retain
their Units) remains a speculative investment. The Funds are acquiring the Units
for investment purposes and do not currently intend to make any effort to change
the management or operations of the Partnership and have no current plans for
any extraordinary transaction regarding the Partnership.
 
    The Purchaser is not affiliated with the General Partner of the Partnership.
 
    As of the date of this Offer, the General Partner of ALZA TTS Research
Partners, Ltd., ALZA Development Corporation, has not made any recommendation to
any Holders as to whether to tender or refrain from tendering Units. Each Holder
must make his or her own decision whether to tender or refrain from tendering
his or her Units. No later than 10 business days from the date of this Offer,
the General Partner is required by law to issue a statement that (i) the
Partnership accepts or rejects the Offer, (ii) the Partnership expresses no
opinion and is remaining neutral toward the Offer or (iii) the Partnership is
unable to take a position with respect to the Offer.
 
    The Offer is conditioned upon, among other things, Purchaser being
satisfied, prior to the Expiration Date, in its reasonable discretion, that,
upon purchase of the Units pursuant to the Offer, it, the Funds and/or their
nominee will have full rights to ownership as to all such Units and that the
General Partner will consent to it, the Funds or their nominee becoming
assignees of the purchased Units and a substitute limited partner with respect
to all such Units. The Offer is also subject to certain other conditions
contained in this Offer to Purchase. See Sections 2 and 14.
 
    According to the Quarterly Report on Form 10-Q for the quarter ended
September 30, 1997 filed by the Partnership (the "Partnership 10-Q"), 3,200
Units were issued and outstanding.
 
    Tendering Holders will not be obligated to pay brokerage fees or commissions
or transfer taxes, if applicable, on the purchase of Units pursuant to the
Offer. Purchaser will pay all charges and expenses of State Street Bank and
Trust Company, as the depositary (the "Depositary"), and MacKenzie Partners,
Inc., as the information agent (the "Information Agent"), incurred in connection
with the Offer. See Section 16.
 
    According to the Partnership's February 1983 Prospectus, the Partnership's
principal objective was to achieve substantial returns to investors by investing
in the development and commercialization of new transdermal therapeutic systems,
which are pharmaceutical products being developed by ALZA Corporation. In
pursuing this strategy, all available Partnership development funds were
expended before 1988. Two of the projects were completed and were cleared for
marketing in the United States and several additional countries. From inception
through September 30, 1997, each Holder had received cumulative
 
                                       5
<PAGE>
distributions of $7,143 per $5,000 Unit and will receive the December 1997
distribution regardless of whether the Holder's Units are tendered. See Section
13.
 
A Holder may wish to tender Units for a number of reasons:
 
- -  PREMIUM TO HISTORICAL OFFERS.  Since there is no trading market in the Units,
    the price at which Units are bought and sold varies greatly depending on the
    venue in which buyers and sellers are matched. On various partnership
    matching services of which the Purchaser is aware, approximately 15 Units
    have been auctioned to the highest bidder over the last 12 months. According
    to Partnership Spectrum, in this venue Units have sold for a weighted
    average price of $8,889 over the last year, with the highest price of which
    PharmaInvest is aware having been $10,625 (after commissions and the
    anticipated distribution of $700 that will be made to Holders in December).
    In addition, there have been a number of unregistered offers made directly
    to Holders, the most recent of which PharmaInvest is aware was priced at
    $6,000 per Unit ($4,600 after adjusting for distributions made or expected
    to be made prior to the closing of the Offer).
 
- -  POTENTIAL TAX BENEFIT, ENHANCED BY CHANGE IN CAPITAL GAIN RATES TO 20%.  Each
    Holder is generally taxable on his or her allocable share of Partnership
    profits, which are ordinary income. Ordinary income is taxed to individuals
    at rates of up to 39.6% at the federal level. The gain resulting from the
    sale of a Unit generally should be taxed to Holders at capital gain rates
    (currently 20% for most individuals disposing of capital assets held more
    than 18 months). A Holder who has been a limited partner since the original
    offering will generally have no basis in the Units. As a result, all or
    substantially all of the Purchase Price should be taxable as capital gain.
    The Purchaser is not expressing an opinion as to the tax consequences of
    tendering Units. Holders are strongly advised to consult their tax advisors
    with respect to the tax consequences of accepting the Offer.
 
    The following example illustrates the potential federal income tax
consequences to Holders for whom the Units are capital assets that have no
remaining basis and have been held for more than 18 months. Note that the
example does not reflect the impact, if any, of state and local taxes on the
disposition or retention of the Units.
 
<TABLE>
<S>                                                             <C>
ACCEPTING THE OFFER:
- --------------------------------------------------------------
Purchase Price................................................  $   12,000
Less: federal capital gains tax (20%).........................      (2,400)
                                                                ----------
Net proceeds..................................................  $    9,600
 
RETAINING YOUR UNITS:
- --------------------------------------------------------------
Distributions for the preceding 12 months.....................  $    2,418
Less: federal ordinary income tax (39.6%).....................        (957)
                                                                ----------
Net distributions.............................................  $    1,461
 
Net proceeds as a multiple of last 12 months distributions
  (net of federal taxes):.....................................       6.5 x
</TABLE>
 
    AS SHOWN ABOVE, BASED ON THE LAST 12 MONTHS AFTER-TAX DISTRIBUTIONS OF
$1,461, A HOLDER WHO RETAINS HIS/HER UNITS WOULD HAVE TO HOLD THE UNITS FOR AN
ADDITIONAL 6 1/2 YEARS TO REALIZE THE $9,600 OF AFTER-TAX PROCEEDS RECEIVED BY
ACCEPTING THE OFFER.
 
- -  SIMPLIFIED TAX RETURNS.  The Offer may be attractive to certain Holders who
    wish in the future to avoid the expenses, delays and complications of filing
    complex income tax returns resulting from Form K-1s necessitated by
    ownership of Units.
 
- -  LIQUIDITY OPPORTUNITY.  The Offer provides each Holder the opportunity to
    liquidate his or her investment in the Partnership without transfer fees and
    transaction costs generally incurred in secondary
 
                                       6
<PAGE>
    market sales. Although there are limited resale mechanisms available to
    Holders through partnership matching services, there is no formal trading
    market for the Units.
 
- -  VALUE DEPENDENT ON ONE PRODUCT.  The bulk of the Partnership's value is based
    on the right to receive royalties on the sales of Duragesic. While the sales
    of Duragesic have grown over the last several years, there can be no
    assurance that they will continue to do so. ALZA and its marketing partner
    for Duragesic, Jannsen Pharmaceutica, are developing E-transfentanyl, a
    product that may be competitive with Duragesic. The Offer enables a Holder
    the opportunity to eliminate uncertainty with respect to future sales of
    Duragesic.
 
1. TERMS OF THE OFFER
 
    Upon the terms and subject to the conditions of the Offer (including, if the
Offer is extended or amended, the terms and conditions of any such extension or
amendment), Purchaser will accept for payment (and thereby purchase) up to 1,400
Units that are validly tendered and not withdrawn in accordance with Section 4
prior to the Expiration Date. As used in the Offer, the term "Expiration Date"
means 12:00 midnight, New York City time, on December 19, 1997, unless and until
Purchaser, in accordance with the terms of the Offer, shall have extended the
period of time during which the Offer is open, in which event the term
"Expiration Date" means the latest time and date at which the Offer, as so
extended, expires. As used in this Offer to Purchase, "business day" has the
meaning set forth in Rule 14d-1(c)(6) under the Securities Exchange Act of 1934,
as amended (the "Exchange Act").
 
    The Offer is not conditioned upon any minimum number of Units being
tendered. The Offer is subject to certain other conditions set forth in Sections
2 and 14. Purchaser expressly reserves the right (but will not be obligated) to
waive any or all of the conditions of the Offer. If, by the Expiration Date, any
or all of the conditions of the Offer are not satisfied or waived, Purchaser
reserves the right (but shall not be obligated) to (i) extend the period during
which the Offer is open and, subject to the rights of tendering Holders to
withdraw their Units, retain all tendered Units until the Expiration Date, (ii)
waive any or all of the conditions of the Offer and, subject to compliance with
applicable rules and regulations of the Securities and Exchange Commission (the
"Commission"), accept for payment or purchase all validly tendered Units and not
extend the Offer, or (iii) terminate the Offer and not accept for payment any
Units and return promptly all tendered Units to tendering Holders. Any
extension, delay in payment, termination or amendment may be made by giving oral
or written notice to the Depositary and will be followed as promptly as
practicable by public announcement, the announcement in the case of an extension
to be issued no later than 9:00 a.m., New York City time, on the next business
day after the previously scheduled Expiration Date.
 
    Following the expiration of the Offer or if the Offer is not consummated,
the Purchaser and the Funds may seek to acquire Units through open-market
purchases, privately negotiated transactions or otherwise, upon such terms and
conditions and at such prices as it shall determine, which may be more or less
than the Purchase Price and could be for cash or other consideration.
 
    The Commission has announced that, under its interpretation of Rules
14d-4(c) and 14d-6(d) under the Exchange Act, material changes in the terms of a
tender offer or information concerning a tender offer may require that the
tender offer be extended so that it remains open a sufficient period of time to
allow Holders to consider such material changes or information in deciding
whether or not to tender or withdraw their securities. The minimum period during
which an offer must remain open following material changes in the terms of the
Offer or information concerning the Offer, other than a change in price or a
change in percentage of securities sought, will depend upon the facts and
circumstances, including the relative materiality of the terms or information.
If Purchaser decides to increase or decrease the consideration in the Offer or
to make a change in the percentage of Units sought and if, at the time that
notice of any such change is first published, sent or given to Holders, the
Offer is scheduled to expire at any time earlier than
 
                                       7
<PAGE>
the tenth business day after (and including) the date of that notice, the Offer
will be extended at least until the expiration of that period of ten business
days.
 
2. PRORATION; ACCEPTANCE FOR PAYMENT AND PAYMENT
 
    If more than 1,400 Units are validly tendered on or prior to the Expiration
Date and not properly withdrawn on or prior to the Expiration Date, the
Purchaser will only accept for payment, upon the terms and subject to the
conditions of the Offer, and pay for an aggregate of 1,400 Units so tendered,
pro rata according to the number of Units validly tendered and not properly
withdrawn on or prior to the Expiration Date, with appropriate adjustments to
avoid purchases in fractions of other than half Units. If the number of Units
validly tendered and not properly withdrawn on or prior to the Expiration Date
is less than or equal to 1,400 Units, the Purchaser will purchase all Units so
tendered and not properly withdrawn, upon the terms and subject to the
conditions of the Offer.
 
    In the event that proration is required, the Purchaser will announce the
final results of such proration as soon as practicable after the Expiration
Date.
 
    Upon the terms and subject to the conditions of the Offer (including, if the
Offer is extended or amended, the terms and conditions of any such extension or
amendment), Purchaser will accept for payment (and thereby purchase) and pay for
all Units which are validly tendered (and not properly withdrawn) prior to the
Expiration Date, promptly following the Expiration Date. Subject to the
applicable rules of the Commission, including Rule 14e-1(c), Purchaser expressly
reserves the right to delay acceptance for payment of or payment for Units
pending receipt of any regulatory approval specified in Section 15 or in order
to comply, in whole or in part, with any other applicable law or government
regulation. See Sections 14 and 15.
 
    In all cases, payment for Units purchased pursuant to the Offer will be made
only after timely receipt by the Depositary of (i) the Letter of Transmittal
properly completed and duly executed with notarized signatures and (ii)
confirmation to Purchaser of such Holder's ownership by ALZA Development
Corporation, the registrar and transfer agent of the Units.
 
    For purposes of the Offer, Purchaser will be deemed to have accepted for
payment and thereby purchased Units validly tendered and not properly withdrawn
if and when Purchaser gives oral or written notice to the Depositary of
Purchaser's acceptance of such Units for payment. Payment for Units accepted
pursuant to the Offer will be made by deposit of the Purchase Price with the
Depositary, which will act as agent for tendering Holders for the purpose of
receiving payment from Purchaser and transmitting payment to tendering Holders.
Upon the deposit of funds with the Depositary for the purpose of making payments
to tendering Holders, Purchaser's obligation to make such payment shall be
satisfied and tendering Holders must thereafter look solely to the Depositary
for payment of amounts owed to them by reason of the acceptance for payment of
Units pursuant to the Offer. Purchaser will pay any transfer taxes incident to
the transfer to it of validly tendered Units, as well as any charges and
expenses of the Depositary and the Information Agent. Under no circumstances
will interest accrue on the consideration to be paid for the Units by Purchaser,
regardless of any delay in making such payment.
 
    If, prior to the Expiration Date, Purchaser increases the consideration to
be paid per Unit pursuant to the Offer, Purchaser will pay the increased
consideration for all the Units purchased pursuant to the Offer, whether or not
the Units were tendered prior to the increase in consideration. Purchaser does
not currently expect to increase the consideration to be paid per Unit pursuant
to the Offer.
 
    Purchaser reserves the right to transfer or assign, in whole at any time, or
in part from time to time, to one or more of its affiliates, the right to
purchase all or any portion of the Units tendered pursuant to the Offer,
provided that any such transfer or assignment will not relieve Purchaser of its
obligations under the Offer and will in no way prejudice the rights of tendering
Holders to receive payment for Units validly tendered and accepted for payment
pursuant to the Offer.
 
                                       8
<PAGE>
3. PROCEDURE FOR TENDERING UNITS
 
    VALID TENDERS.  For Units to be validly tendered pursuant to the Offer, a
Letter of Transmittal, properly completed and duly executed, with notarized
signatures and any other documents required by the Letter of Transmittal, must
be postmarked prior to the Expiration Date.
 
    NOTARIZED SIGNATURES.  In all cases, signatures on the Letter of Transmittal
must be notarized. SEE INSTRUCTION 2 OF THE LETTER OF TRANSMITTAL. If the Units
are registered in the name of a person other than the signer of the Letter of
Transmittal, or if payment is to be made to a person other than the registered
Holder of the Units surrendered, then the Letter of Transmittal for the tendered
Units must be endorsed or accompanied by appropriate stock powers, in each case
signed exactly as the name or names of the registered Holder appears in the
records of ALZA Development Corporation. SEE INSTRUCTIONS 1 AND 2 OF THE LETTER
OF TRANSMITTAL.
 
    IN ALL CASES, UNITS SHALL NOT BE DEEMED VALIDLY TENDERED UNLESS A PROPERLY
COMPLETED AND DULY EXECUTED LETTER OF TRANSMITTAL IS RECEIVED BY THE DEPOSITARY.
 
    THE METHOD OF DELIVERY OF THE LETTER OF TRANSMITTAL AND ANY OTHER REQUIRED
DOCUMENTS IS AT THE OPTION AND RISK OF THE TENDERING HOLDER. IF DELIVERY IS MADE
BY MAIL, REGISTERED MAIL WITH RETURN RECEIPT REQUESTED IS RECOMMENDED. IN ALL
CASES, SUFFICIENT TIME SHOULD BE ALLOWED TO ENSURE TIMELY DELIVERY.
 
    Notwithstanding any other provision of this Offer to Purchase, subject to
the applicable rules of the Commission, including Rule 14e-1(c), payment for
Units accepted for payment pursuant to the Offer in all cases will be made only
after timely receipt by the Depositary of confirmation of such Holder's
ownership by ALZA Development Corporation, the registrar and transfer agent for
the Units, and a Letter of Transmittal, properly completed and duly executed,
with notarized signatures, and all other documents required by the Letter of
Transmittal.
 
    DETERMINATION OF VALIDITY.  All questions as to the form of documents and
the validity, eligibility (including time of receipt) and acceptance for payment
of any tender of Units pursuant to any of the procedures described above will be
determined by Purchaser in its reasonable discretion, which determination shall
be final and binding on all parties. Purchaser reserves the absolute right to
reject any or all tenders of Units determined not to be in proper form or the
acceptance of or payment for which may, in the opinion of counsel, be unlawful
and reserves the absolute right to waive any defect or irregularity in any
tender of Units. Purchaser also reserves the absolute right to waive or amend
any or all of the conditions of the Offer prior to the Expiration Date.
Purchaser's interpretation of the terms and conditions of the Offer (including
the Letter of Transmittal and its instructions) will be final and binding on all
parties. No tender of Units will be deemed to have been validly made, until all
defects and irregularities have been cured or waived. None of Purchaser, the
Depositary, the Information Agent or any other person will be under any duty to
give notification of any defects or irregularities in tenders or incur any
liability for failure to give any such notification.
 
    APPOINTMENT AS PROXY.  By executing and delivering the Letter of
Transmittal, a tendering Holder irrevocably appoints designees of Purchaser as
his or her attorneys-in-fact and proxies, with full power of substitution, in
the manner set forth in the Letter of Transmittal, to the full extent of the
Holder's rights with respect to the Units (and with respect to any and all other
securities issued or issuable in respect of such Units on or after the date
hereof) tendered by the Holder. All such powers of attorney and proxies will be
considered coupled with an interest in the tendered Units and all prior powers
of attorney and proxies given by the Holder with respect to the Units will be
revoked, without further action, and no subsequent powers of attorney and
proxies may be given (and, if given, will not be deemed effective) by the
Holder. Designees of Purchaser will be empowered to exercise all voting and
other rights of the Holder with respect to such Units as they in their
reasonable discretion may deem proper, including, without limitation, in respect
of any annual or special meeting of the Holders, or any adjournment or
postponement of any such meeting, or in connection with any action by written
consent in lieu of any such meeting
 
                                       9
<PAGE>
or otherwise. Purchaser reserves the right to require that, in order for Units
to be validly tendered, immediately upon Purchaser's acceptance for payment of
the Units, Purchaser must be able to exercise full voting and other rights with
respect to the Units.
 
    A tender of Units pursuant to any of the procedures described above will
constitute the tendering Holder's acceptance of the terms and conditions of the
Offer. Purchaser's acceptance for payment of Units tendered pursuant to the
Offer will constitute a binding agreement between the tendering Holder and
Purchaser upon the terms and conditions of the Offer.
 
4. WITHDRAWAL RIGHTS
 
    Tenders of Units made pursuant to the Offer are irrevocable, except as
otherwise provided in this Section 4. Units tendered pursuant to the Offer may
be withdrawn at any time prior to the Expiration Date and, unless theretofore
accepted for payment by Purchaser as provided in this Offer to Purchase, may
also be withdrawn at any time after January 18, 1998. If Purchaser extends the
Offer, is delayed in its purchase of or payment for Units, or is unable to
purchase or pay for Units for any reason then, without prejudice to the rights
of Purchaser, tendered Units may be retained by the Depositary on behalf of
Purchaser and may not be withdrawn, except to the extent that tendering Holders
are entitled to withdrawal rights as set forth in this Section 4.
 
    The reservation by Purchaser of the right to delay the acceptance or
purchase of or payment for Units is subject to the provisions of Rule 14e-1(c)
under the Exchange Act, which requires Purchaser to pay the consideration
offered or to return Units deposited by or on behalf of Holders promptly after
the termination or withdrawal of the Offer.
 
    For a withdrawal to be effective, a written, telegraphic or facsimile
transmission notice of withdrawal must be timely received by the Depositary at
it address set forth on the back cover of this Offer to Purchase. Any such
notice of withdrawal must specify the name of the persons who tendered the Units
to be withdrawn, the number of Units to be withdrawn and the name of the
registered Holder, if different from that of the person who tendered the Units.
All questions as to the form and validity (including time of receipt) of notices
of withdrawal will be determined by Purchaser, in its reasonable discretion,
whose determination will be final and binding on all parties. No withdrawal of
Units will be deemed to have been made properly until all defects and
irregularities have been cured or waived. None of Purchaser, the Depositary, the
Information Agent or any other person will be under any duty to give
notification of any defects or irregularities in any notice of withdrawal or
incur any liability for failing to give such notification.
 
    Any Units properly withdrawn will be deemed not validly tendered for
purposes of the Offer, but may be tendered at any subsequent time prior to the
Expiration Date by following any of the procedures described in Section 3 above.
 
5. CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE OFFER
 
    The following is a general discussion of certain federal income tax
consequences of a sale of Units pursuant to the Offer, assuming that the
Partnership is treated and taxable as a partnership for federal income tax
purposes. This summary is of a general nature only and does not discuss all
aspects of federal income taxation that may be relevant to each Holder in light
of such Holder's particular circumstances. In addition, the summary does not
discuss aspects of federal income taxation that may be relevant to Holders
subject to special treatment under the federal income tax laws, such as foreign
persons, dealers in securities, insurance companies, tax-exempt organizations,
banks, thrifts, regulated investment companies or Holders that do not hold Units
as capital assets (within the meaning of Section 1221 of the Internal Revenue
Code of 1986, as amended (the "Code")). This summary is based on the Code,
Treasury regulations thereunder, and administrative and judicial interpretations
thereof, as of the date hereof, all of which are subject to change, possibly on
a retroactive basis.
 
                                       10
<PAGE>
    EACH HOLDER SHOULD CONSULT HIS OR HER OWN TAX ADVISOR AS TO THE PARTICULAR
TAX CONSEQUENCES TO SUCH HOLDER OF SELLING UNITS PURSUANT TO THIS OFFER. THIS
SUMMARY DOES NOT DISCUSS ANY FOREIGN, STATE OR LOCAL TAX CONSEQUENCES OF SELLING
UNITS PURSUANT TO THIS OFFER.
 
    CONSEQUENCES TO HOLDERS WHO TENDER UNITS.  A Holder who tenders Units
pursuant to the Offer generally will recognize gain or loss equal to the
difference between (i) the Holder's "amount realized" and (ii) the Holder's
adjusted tax basis in the Units tendered. The amount realized with respect to a
Unit sold pursuant to the Offer is the sum of the amount of cash received by the
Holder for such Unit and such Holder's share of Partnership liabilities
allocable to such Unit (as determined under Section 752 of the Code). The amount
of a Holder's adjusted tax basis in his or her Units will vary depending on the
Holder's particular circumstances, and will be affected by allocations of
Partnership income, gain and loss during the year in which Units are tendered,
distributions, if any, made by the Partnership to a Holder with respect to such
Units during such year, and also any increases or decreases in the Holder's
share of Partnership liabilities. The Partnership's taxable income, gain and
loss for the taxable year will be allocated between the Purchaser and tendering
Holders in accordance with the terms of the Partnership Agreement.
 
    TAX BASIS IN UNITS.  The IRS has ruled that a partner has one basis for the
partner's entire interest in a partnership even if a partner bought partnership
interests in different transactions. Upon a sale of a portion of such aggregate
interest (e.g., in a partial tender of Units), a Holder would be required to
allocate such Holder's aggregate tax basis between the Units sold and the Units
retained using some equitable apportionment method, such as the relative fair
market value of such Units on the date of sale. It is not entirely clear whether
the aggregation rule results in the tacking of the holding period of earlier
purchased Units to more recently acquired Units.
 
    CHARACTERIZATION OF GAIN OR LOSS.  Gain or loss recognized by a Holder on
the sale of Units pursuant to the Offer generally will be capital gain or loss.
However, under Section 751 of the Code, the difference between the portion of
the amount realized by a Holder that is attributable to "unrealized receivables"
and "inventory" (together, "Section 751 Property") over the portion of the
Holder's adjusted tax basis in the Unit that is allocated to Section 751
Property will be treated as ordinary income or loss, rather than capital gain or
loss. In certain cases, ordinary income recognized under Section 751 of the Code
may exceed net taxable gain realized on the sale of a Unit and may be recognized
even if there is a net taxable loss realized on the sale of a Unit. Existing
Treasury regulations require each person who transfers an interest in a
partnership possessing Section 751 Property to file a statement with such
person's tax return reporting the transfer and certain other information
relating thereto.
 
    The Taxpayer Relief Act of 1997 (HR 2014) (the "Act"), enacted into law on
August 5, 1997, generally reduces the maximum rate of tax on net capital gain
for individuals, estates and trusts from 28% to 20% (in addition, the Act
provides for additional rate reductions on gains attributable to dispositions of
certain property for the taxable years beginning after December 31, 2000).
However, for sales or exchanges of capital assets after July 28, 1997, the 20%
rate applies only to gains attributable to such assets that were held for more
than 18 months. The 20% rate does not apply to gain on the sale of collectibles
and to certain other gain. The 28% rate continues to apply to gains attributable
to sales or exchanges of capital assets held for more than one year but not more
than 18 months. For non-corporate taxpayers, capital losses are deductible only
to the extent of capital gains plus up to $3,000 of ordinary income. If capital
losses are not used in a tax year, such losses generally can be carried forward
to succeeding tax years indefinitely. Non-corporate taxpayers are not entitled
to carry back capital losses to prior taxable years.
 
    Under current law, the maximum federal income tax rate applicable to capital
gains and ordinary income for corporations is 35%. Corporations may only offset
capital losses against capital gains. Corporations are entitled to carry back
unused capital losses to the three preceding taxable years and carry forward
unused capital losses to the succeeding five taxable years.
 
                                       11
<PAGE>
    EFFECT OF PASSIVE LOSS RULES.  Under Section 469 of the Code, a
non-corporate taxpayer or personal service corporation generally can deduct
passive activity losses in any year only to the extent of such person's passive
activity income for such year, and closely held corporations may not offset such
losses against so-called "portfolio" income. Provided that a Holder is subject
to the passive activity loss rules in connection with the ownership of Units, a
Holder with "suspended" passive activity losses generally should be entitled to
offset such losses against any income or gain recognized by the Holder on a sale
of all of such Units (subject to certain other limitations). If a Holder does
not sell all of his or her Units, the passive activity loss limitations would
continue to apply until the Holder disposes of all of his or her remaining
Units.
 
    BACK-UP WITHHOLDING.  A Holder (other than corporations and certain foreign
individuals) who tenders Units may be subject to 31% backup withholding unless
he or she provides a taxpayer identification number ("TIN") and certifies that
the TIN is correct or properly certifies that he or she is awaiting a TIN. A
Holder may avoid backup withholding by properly completing and signing the
Substitute Form W-9 included as part of the Letter of Transmittal. IF A HOLDER
WHO IS SUBJECT TO BACKUP WITHHOLDING DOES NOT PROPERLY COMPLETE AND SIGN THE
SUBSTITUTE FORM W-9, THE PURCHASER WILL WITHHOLD 31% FROM PAYMENTS TO SUCH
HOLDER. SEE INSTRUCTION 4 TO THE LETTER OF TRANSMITTAL.
 
    POSSIBLE LEGISLATIVE TAX CHANGES.  There have been a number of proposals
made in Congress and by the Treasury Department and other government agencies
for changes in the federal income tax laws. In addition, the Internal Revenue
Service has proposed and may still be considering changes in regulations and
procedures. It is likely that further proposals will be forthcoming or that
previous proposals will be revived in some form in the future. It is impossible
to predict with any degree of certainty what past proposals may be revived or
what new proposals may be forthcoming, the likelihood of adoption of any such
proposals, the likely effect of any such proposals upon investment in the
Partnership or upon the sale of Units, or the effective date of any legislation
which may derive from any such past or future proposals. Holders are strongly
urged to consider ongoing developments in this uncertain area.
 
THE FEDERAL INCOME TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL
INFORMATION PURPOSES ONLY. LIMITED PARTNERS SHOULD CONSULT THEIR OWN TAX
ADVISORS TO DETERMINE THE FEDERAL, STATE, LOCAL AND FOREIGN TAX CONSEQUENCES OF
THE OFFER.
 
                                       12
<PAGE>
6. PRICE RANGE OF THE UNITS
 
    According to the Annual Report on Form 10-K for the fiscal year ended
December 31, 1996 filed by the Partnership (the "Partnership 10-K") "there is no
established public trading market for the Units." According to Partnership
Spectrum, an independent third-party industry publication that tracks recent
trades in certain limited partnership interests, for the twelve months ended
July 31, 1997, 13 Units traded at per Unit prices between $7,500 and $9,258 with
a weighted average of $8,347 per Unit. The most recent issue of Partnership
Spectrum (July/August, 1997) indicates that 5.0 Units traded in the period June
1, 1997 through July 31, 1997 at between $7,500 and $8,800 per Unit, with a
weighted average of $7,760 per Unit.
 
        Trading Activity for the Twelve-Month Period Ended July 31, 1997
 
<TABLE>
<CAPTION>
                                                   WEIGHTED                        NUMBER OF        NUMBER        TOTAL
                     PERIOD                         AVERAGE       LOW/HIGH       UNITS TRADED      OF TRADES      VOLUME
- ------------------------------------------------  -----------  ---------------  ---------------  -------------  ----------
<S>                                               <C>          <C>              <C>              <C>            <C>
August 1, 1996 - September 30, 1996.............      --             N/A              --              --            --
October 1, 1996 - November 30, 1996.............      --             N/A              --              --            --
December 1, 1996 - January 31, 1997.............      --             N/A              --              --            --
February 1, 1997 - March 31, 1997...............   $   8,715   $  8,300/$9,258           8.0             4.0    $   69,716
April 1, 1997 - May 31, 1997....................      --             N/A              --              --            --
June 1, 1997 - July 31, 1997....................   $   7,760   $  7,500/$8,800           5.0             2.0    $   38,800
                                                                                                          --
                                                  -----------  ---------------           ---                    ----------
                                                   $   8,347   $  7,500/$9,258          13.0             6.0    $  108,516
                                                                                                          --
                                                                                                          --
                                                  -----------                            ---                    ----------
                                                  -----------                            ---                    ----------
</TABLE>
 
    On November 1, 1997, the Purchaser acquired 2 Units for $12,411 per Unit.
The Purchaser expects to receive the fourth quarter 1997 distribution which it
estimates to approximate $700.
 
    Holders are advised, however, that such sales prices as reported by
Partnership Spectrum are on a gross basis and do not necessarily reflect the net
sales proceeds received by sellers of Units, which typically are reduced by
commissions and other secondary market transaction costs. Also, trades may have
occurred at higher or lower prices which were not reported by Partnership
Spectrum and the Purchaser makes no representation as to the accuracy or
completeness of the trade information. Not all trades are reported in
Partnership Spectrum.
 
    The Purchase Price represents the price at which the Purchaser is willing to
purchase Units. No independent person has been retained to evaluate or render
any opinion with respect to the fairness of the Purchase Price and no
representation is made by the Purchaser or any affiliate of the Purchaser as to
such fairness. Purchaser did not attempt to obtain current independent
valuations or appraisals of the underlying assets owned by the Partnership.
Other measures of the value of the Units may be relevant to Holders. See Section
8. HOLDERS ARE URGED TO CONSIDER CAREFULLY ALL OF THE INFORMATION CONTAINED
HEREIN AND CONSULT WITH THE OWN ADVISORS, TAX, FINANCIAL OR OTHERWISE, IN
EVALUATING THE TERMS OF THE OFFER BEFORE DECIDING WHETHER TO TENDER UNITS.
 
7. EFFECT OF THE OFFER ON EXCHANGE ACT REGISTRATION
 
    The Units are currently registered under the Exchange Act. Such registration
may be terminated upon application of the Partnership to the Commission if the
Units are neither listed on a national securities exchange nor held by 300 or
more holders of record. Termination of the registration of the Units under the
Exchange Act would substantially reduce the information required to be furnished
by the Partnership to Holders and to the Commission and would make certain of
the provisions of the Exchange Act no longer applicable to the Units. The
Purchaser currently has no plans to seek to cause the Partnership to terminate
such registration.
 
                                       13
<PAGE>
8. CERTAIN INFORMATION CONCERNING THE PARTNERSHIP
 
    The Partnership was formed to fund the development and clinical testing of
six products based on ALZA's transdermal drug delivery technology. In March
1983, Merrill Lynch placed 3,200 Units at $5,000 each with approximately 2,000
Holders. The Partnership also sold a Class B limited partnership interest to
Stada Arzneimittel AG ("Stada" or the "Class B Limited Partner"), a German
pharmaceutical company for $750,000. ALZA Development Corporation ("ADC"), a
wholly-owned subsidiary of ALZA is the General Partner of the Partnership and
contributed 1% of the Partnership's total capitalization of $16.9 million. The
Partnership will terminate on January 31, 2004, unless its term is extended or
reduced by the General Partner.
 
    The Partnership has completely expended its funds for research and
development of products ("TTS Partnership Products") which combine certain
generic drug compounds in specified areas of therapy with ALZA's proprietary
transdermal therapeutic system ("TTS") technology. It has licensed two TTS
Partnership Products. One, TTS-fentanyl or Duragesic, is a narcotic analgesic
transdermally administered for management of severe chronic pain when opioid
analgesia is indicated such as in the management of cancer pain. Duragesic is
marketed by Janssen Pharmaceutica throughout the world and co-marketed by ALZA
in the U.S. TTS-testosterone or Testoderm-Registered Trademark-, is a
controlled-release dosage form of the major male hormone testosterone, designed
to re-establish in hypogonadal males the plasma concentrations of testosterone
observed in healthy young men. It is marketed by ALZA in the U.S. and through
distributors in Asia and Europe.
 
    The Partnership receives a 4% royalty on net sales of the two products until
the expiration of the respective patents -- April 2006 for Duragesic and
February 2005 for Testoderm. ALZA has indicated in oral communications with the
Purchaser that it will establish a liquidating trust to ensure royalties are
paid and received by the former limited partners, since the Partnership is
scheduled to dissolve prior to the expiration of certain patents covering these
TTS Partnership Products.
 
    The Partnership has delegated to the General Partner, pursuant to Limited
Partnership Agreement, responsibility for management and administrative services
necessary for the operation of the Partnership.
 
    LICENSE OPTION.  The Partnership granted to ALZA an option whereby ALZA had
a right to acquire a license to the Partnership's products. The license is
exclusive for 13 years after the actual reduction to practice of the product,
after which the license becomes non-exclusive. In 1990, ALZA exercised this
option for both Duragesic and Testoderm. ALZA's exclusivity lapses for Duragesic
on December 4, 1998 and for Testoderm on July 26, 1998. On these dates the
General Partner must determine whether to license the products to other
companies. Duragesic is currently marketed by Janssen Pharmaceutica throughout
the world and co-marketed by ALZA in the U.S. Testoderm is currently marketed by
ALZA in the U.S. and through distributors in Asia and Europe.
 
    PARTNERSHIP PURCHASE OPTION.  When the Partnership was formed, the General
Partner was granted an option to acquire all of the limited partnership
interests in the Partnership (the "Purchase Option"). During 1987 and 1988, the
General Partner could have exercised this option for $60 million and $90
million, respectively. From 1989 onwards it had and still has the right to
purchase the limited partnership interests for the greater of $50 million or
$120 million less cumulative distributions to the limited partners. Through
September 30, 1997, approximately $22.9 million had been distributed to the Unit
Holders since the Partnership's inception. The General Partner can currently
exercise this option to purchase the Holders' interests for a lump sum payment
of approximately $91.8 million (not including the $5.3 million lump sum payment
that would be payable to the Class B Partner). According to the Partnership
10-Q, the General Partner has not made a determination as to whether to exercise
the Purchase Option.
 
    THE GENERAL PARTNER.  The General Partner, ALZA Development Corporation, is
a wholly-owned subsidiary of ALZA Corp. ("ALZA"). Incorporated in 1968 and
located in California, ALZA is in the business of developing and commercializing
innovative pharmaceutical products that incorporate drugs
 
                                       14
<PAGE>
into advanced dosage forms designed to provide controlled, predetermined rates
of drug release for extended time periods. Other than the TTS Partnership
Products, ALZA-developed products include Procardia XL-Registered Trademark- for
the treatment of angina and hypertension, Transderm-Nitro-Registered Trademark-
for the prevention and treatment of angina and NicoDerm-Registered Trademark-
for use as an aid in smoking cessation.
 
    THE PARTNERSHIP'S ASSETS AND BUSINESS.  The Partnership is a California
limited partnership with its principal executive offices located at 950 Page
Mill Rd., P.O. Box 10950, Palo Alto, CA 94303-0802. According to the Partnership
10-K, the Partnership commenced operations on December 30, 1982.
 
    DETERMINATION OF PURCHASE PRICE OF UNITS.  The Purchaser has determined the
Purchase Price by dividing the sum of (i) Purchaser's own estimate of the
present value of future cash flows that may be derived from the Partnership's
holdings and (ii) Purchaser's own estimate of the current market value of the
Partnership's other net assets, by the number of Units outstanding. In addition,
the Purchaser compared the Purchase Price to the recent trading prices for the
small number of Units that have been sold through partnership matching services.
All of the information considered by the Purchaser in determining the Purchase
Price is publicly available. The principal assets of the Partnership are rights
to receive contingent payments based on sales of two pharmaceutical products in
which the Partnership has a direct interest.
 
    The Purchaser's $38.4 million valuation of the Partnership's assets at
September 30, 1997 can be summarized as follows:
 
<TABLE>
<CAPTION>
                                                                                  PURCHASER'S
                                                                                   ESTIMATE
ASSET                                                                              OF VALUE
- -------------------------------------------------------------------------------  -------------
<S>                                                                              <C>
Net Working Capital............................................................  $    --
Duragesic Royalty Interest.....................................................     37,825,000
Testoderm Royalty Interest.....................................................        575,000
                                                                                 -------------
                                                                                 $  38,400,000
                                                                                 -------------
                                                                                 -------------
Valuation per Unit.............................................................  $      12,000
                                                                                 -------------
                                                                                 -------------
</TABLE>
 
    No third party was retained by the Purchaser to value the Units or to render
any fairness opinion with respect to the Purchase Price. No representation is
made as to the fairness of the Purchase Price. No other valuation analysis was
performed or used, including any liquidation value or net asset value analysis.
 
    SELECTED FINANCIAL DATA.  Set forth below is certain selected consolidated
financial information, with respect to the Partnership excerpted from the
Partnership's 10-K and the Partnership 10-Q. More comprehensive financial
information is included in such reports and other documents filed by the
Partnership with the Commission, and the following summary is qualified in its
entirety by reference to such reports and other documents and all the financial
information (including any related notes) contained therein. Such reports and
other documents should be available for inspection and copies should be
obtainable in the manner set forth above under "Available Information."
 
                                       15
<PAGE>
                       SELECTED STATEMENTS OF OPERATIONS
                                  (UNAUDITED)
 
<TABLE>
<CAPTION>
                                9 MONTHS
                                  ENDED                        FOR THE YEARS ENDED DECEMBER 31,
                              SEPTEMBER 30,  --------------------------------------------------------------------
                                  1997           1996          1995          1994          1993          1992
                              -------------  ------------  ------------  ------------  ------------  ------------
<S>                           <C>            <C>           <C>           <C>           <C>           <C>
Total revenue...............   $ 6,700,419   $  6,294,396  $  4,461,900  $  3,178,312  $  2,728,327  $  1,452,897
Net Income..................     6,612,614      6,207,848     4,361,647     3,082,860     7,634,523     1,384,540
Net income allocated to
  Partners:
  Unitholders...............     6,255,533      6,035,020     4,318,031     3,052,032     2,608,178       656,259
  Per Unit..................   $  1,954.85   $   1,885.94  $   1,349.38  $     953.76  $     815.06  $     205.08
  Class B Limited Partner...       290,955        110,749       --            --            --            669,633
  General Partner...........        66,126         62,079        43,616        30,828        26,345        58,648
Total Assets (Cash) at
  December 31...............        98,427         77,586        48,245        28,155        17,757         9,996
Distributions to Partners
  Unitholders...............     6,117,184      5,768,192     4,073,856     2,868,864     2,509,632     1,294,880
  Per Unit..................   $  1,911.62   $   1,802.56  $   1,273.08  $     896.52  $     784.26  $     404.65
  Class B Limited Partner...       284,521        268,287       189,481       133,435       116,728        70,646
  General Partner...........        64,660         60,963        43,064        30,309        26,554        13,815
</TABLE>
 
<TABLE>
<CAPTION>
                                                                        NINE MONTHS ENDED
                                                                          SEPTEMBER 30,
                                                                    --------------------------
                                                                        1997          1996
                                                                    ------------  ------------
<S>                                                                 <C>           <C>
REVENUE:
  Royalty Income..................................................  $  6,429,638  $  4,505,437
  License Fee.....................................................       250,000       --
  Interest Income.................................................        20,781        20,912
                                                                    ------------  ------------
                                                                       6,700,419     4,526,349
Expenses:
  General and Administrative......................................        87,805        58,602
                                                                    ------------  ------------
Net Income........................................................  $  6,612,614  $  4,467,747
                                                                    ------------  ------------
                                                                    ------------  ------------
Allocation of Net Income
  General Partner.................................................  $     66,126  $     44,678
  Class A Limited Partners........................................     6,255,533     4,388,884
  Class B Limited Partner.........................................       290,955        34,185
Net Income per Class A LP Unit....................................  $   1,954.85  $   1,371.53
</TABLE>
 
                                       16
<PAGE>
                   SELECTED STATEMENTS OF FINANCIAL CONDITION
                                  (UNAUDITED)
 
<TABLE>
<CAPTION>
                                                         SEPTEMBER 30, 1997  DECEMBER 31, 1996
                                                         ------------------  -----------------
<S>                                                      <C>                 <C>
Assets
  Cash.................................................      $   98,427         $    77,586
                                                                -------            --------
    Total Assets.......................................      $   98,427         $    77,586
                                                                -------            --------
                                                                -------            --------
Liabilities and partners' capital
  Payable to ALZA Corporation..........................      $   20,973         $   146,381
  Partners' capital (deficit)
    Class A Limited Partners, 3,200 Units
      outstanding......................................          68,445             (69,904)
    Class B Limited Partner............................           8,239               1,805
    General Partner....................................             770                (696)
                                                                -------            --------
      Partners' capital (deficit)......................          77,454             (68,795)
                                                                -------            --------
    Total liabilities and partners' capital (deficit)..      $   98,427         $    77,586
                                                                -------            --------
                                                                -------            --------
</TABLE>
 
    AVAILABLE INFORMATION.  The Partnership is subject to the information filing
requirements of the Exchange Act. In accordance with the requirements of the
Exchange Act, the Partnership files periodic reports, proxy statements and other
information with the Commission relating to its business, financial condition
and other matters. Such reports, proxy statements and other information may be
inspected at the Commission's office at 450 Fifth Street, N.W., Washington, D.C.
20549, and also should be available for inspection and copying at the regional
offices of the Commission located at Northwestern Atrium Center, 500 West
Madison Street, Suite 1400, Chicago, Illinois 60661-2511; and 7 World Trade
Center, 13th Floor, New York, New York 10048. Copies may be obtained upon
payment of the Commission's prescribed fees by writing to its principal office
at 450 Fifth Street, N.W., Washington, D.C. 20549. Such material can also be
obtained at the office of the National Association of Securities Dealers, Inc.,
1735 K Street, N.W., Washington, D.C. 20006-1506. In addition, the Commission
maintains a Web site (http://www.sec.gov) that contains reports, proxy and
information statements and other information regarding registrants that file
electronically with the Commission.
 
    Except as otherwise stated in this Offer to Purchase, the information
concerning the Partnership contained in this Offer to Purchase has been taken
from or is based upon publicly available documents on file with the Commission
or a court and other publicly available information. Although the Purchaser and
the Funds do not have any knowledge that any such information is untrue, the
Purchaser and the Funds take no responsibility for the accuracy or completeness
of such information or for any failure by the Partnership to disclose events
that may have occurred and may affect the significance or accuracy of any such
information.
 
9. CERTAIN INFORMATION CONCERNING PURCHASER
 
    PharmaInvest, L.L.C., a Delaware limited liability company, was formed in
August 1997 to act as nominee for Pharmaceutical Royalties, L.L.C., a Delaware
limited liability company formed in July 1996 and Pharmaceutical Royalty
Investments Ltd., a Bermuda company formed in May 1996, each of which has been
organized to invest in royalty interests and contingent payment rights ("CPRs")
which derive cash payments based on the sale of pharmaceutical and biotechnology
products. Units acquired by Pharmaceutical Royalty Investments Ltd. pursuant to
the Offer will be assigned to certain of its subsidiaries. The Purchaser and the
Funds are managed by Pharmaceutical Partners, L.L.C. ("PPLLC"). The principal
executive offices of PPLLC are located at 70 East 55th Street, 23rd Floor, New
York, NY 10022. PPLLC is
 
                                       17
<PAGE>
the sole member of the Purchaser. The name, business address, present principal
occupation or employment, five-year employment history and citizenship of each
member of PPLLC are set forth in Schedule I hereto.
 
    Except as described in this Offer to Purchase, during the last five years
neither Purchaser, the Funds nor, to the best knowledge of Purchaser and the
Funds, any of the persons listed in Schedule I hereto (i) has been convicted in
a criminal proceeding (excluding traffic violations and similar misdemeanors) or
(ii) was a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction and as a result of such proceeding was or is subject to a
judgment, decree or final order enjoining future violations of, or prohibiting
activities subject to, Federal or state securities laws or finding any violation
of such laws.
 
    Except as described in this Offer to Purchase, (i) neither Purchaser, the
Funds or, to the best knowledge of Purchaser and the Funds, any of the persons
listed in Schedule I hereto or any affiliate of any such person, beneficially
owns or has a right to acquire any Unit and (ii) neither Purchaser, the Funds
or, to the best knowledge of Purchaser and the Funds, any of the other persons
referred to above, or any affiliate of any of the foregoing, has effected any
transaction in the Units during the past 60 days.
 
    Except as described in this Offer to Purchase, (i) neither Purchaser, the
Funds or, to the best knowledge of Purchaser and the Funds, any of the persons
listed in Schedule I has any contract, arrangement, understanding or
relationship (whether or not legally enforceable) with any other person with
respect to any Units, including, but not limited to, any contract, arrangement,
understanding or relationship concerning the transfer or the voting of any
Units, joint ventures, loan or option arrangements, puts or calls, guarantees of
loans, guarantees against loss or the giving or withholding of proxies and (ii)
there have been no contacts, negotiations or transactions between Purchaser, the
Funds or any of their affiliates or, to the best knowledge of Purchaser and the
Funds, any of the persons listed in Schedule I hereto, on the one hand, and the
Partnership or any of its affiliates, on the other hand, that are required to be
disclosed pursuant to the rules and regulations of the Commission.
 
    The following trades for 2.0 Units have been entered into by the Purchaser,
the Funds or their affiliates and have been transferred by the General Partner
as of November 1, 1997.
 
<TABLE>
<CAPTION>
                                                                      PRICE PER       NUMBER OF
TRADE DATE                                                              UNIT            UNITS
- ------------------------------------------------------------------  -------------  ---------------
<S>                                                                 <C>            <C>
November 1, 1997..................................................   $    12,411(1)          2.0
</TABLE>
 
- ------------------------
 
(1) Purchaser expects to receive the 4th quarter 1997 distribution which it
    estimates to approximate $700
 
10. SOURCE AND AMOUNT OF FUNDS
 
    Purchaser estimates that the maximum amount of funds required to purchase
Units pursuant to the Offer and to pay related costs and expenses will be
approximately $17.0 million. The Purchaser presently anticipates that all
amounts required for the purchase of Units and to pay related costs and expenses
will be funded from existing cash balances of the Purchaser and the Funds.
 
11. BACKGROUND OF THE OFFER
 
    It is the business of the Purchaser to identify, evaluate and acquire
pharmaceutical royalty interests. Since the Partnership's principal assets are
the right to receive royalties on the sale of Duragesic and Testaderm, the
Partnership represents an investment opportunity within the scope of the mandate
of the funds managed by Pharmaceutical Partners. Earlier this year, the
Purchaser began to evaluate the Partnership as an investment opportunity. In
doing so, it had a number of conversations with the Investor Relations staff of
ALZA regarding the products in the Partnership, patent expiration dates and the
termination of the Partnership in 2004.
 
                                       18
<PAGE>
    Once the Purchaser had determined that the Partnership represented a
possible investment opportunity, the Purchaser contacted the General Partner to
make it aware of the Purchaser's possible interest. On June 27, the Purchaser
had a telephone conversation with the General Partner regarding its possible
interest in an investment in the Partnership. The Purchaser sent several
additional letters on July 11 and 17 continuing to express its interest in the
Partnership.
 
    In October 1997, the Purchaser had second conversation with the General
Partner reiterating its interest in the Partnership. Following the conversation,
the Purchaser acquired 2 Units, and on October 22 made a written request and
paid a $100 processing fee to receive a list of names and addresses of limited
partners (the "List"). The Purchaser received the List on November 2 and
commenced the Offer on November 20.
 
12. PURPOSE OF THE OFFER; PLANS FOR THE PARTNERSHIP
 
    The purpose of the Offer is to enable the Purchaser and the Funds to acquire
Units in the Partnership. The Purchaser and the Funds are making this Offer
because the Funds believe that the Units represent an attractive investment at
the price offered. There can be no assurance, however, that this belief is
correct and, as a result, ownership of Units (either by the Purchaser, the Funds
or Holders who retain their Units) remains a speculative investment. The Funds
are acquiring the Units for investment purposes and do not currently intend to
make any effort to change the management or operations of the Partnership and
have no current plans for any extraordinary transaction regarding the
Partnership. Following the completion of the Offer, the Purchaser, the Funds and
their affiliates may acquire additional Units. Any such acquisition may be made
through private purchases, through one or more future tender offers or by any
other means deemed advisable, and may be at prices higher or lower than the
price to be paid for the Units purchased in the Offer.
 
    Except as noted in this Offer to Purchase, Purchaser and the Funds have no
present plans or proposals that would result in an extraordinary corporate
transaction, such as a merger, reorganization, liquidation or sale or transfer
of a material amount of assets involving the Partnership or any subsidiary, or
any other material changes in the partnership's capitalization, composition,
distribution policy, structure or business.
 
    No appraisal rights are available to Holders in connection with the Offer.
 
13. DISTRIBUTIONS TO LIMITED PARTNERS
 
    From inception through September 30, 1997, the Partnership distributed
approximately $22.9 million to the Holders.
<TABLE>
<CAPTION>
                                                                                                                       NINE MONTHS
                                                             FOR THE YEARS ENDED DECEMBER 31,                             ENDED
                                       -----------------------------------------------------------------------------    SEPT. 30,
                                        1983-1990     1991       1992       1993       1994       1995       1996         1997
                                       -----------  ---------  ---------  ---------  ---------  ---------  ---------  -------------
<S>                                    <C>          <C>        <C>        <C>        <C>        <C>        <C>        <C>
Dists to Holders (per Unit)                --       $      70  $     405  $     784  $     897  $   1,273  $   1,803    $   1,912
 
<CAPTION>
 
                                       INCEPTION ON
                                         SEPT. 30,
                                           1997
                                       -------------
<S>                                    <C>
Dists to Holders (per Unit)              $   7,143
</TABLE>
 
- ------------------------
 
Note: Figures may not total due to rounding.
 
14. CERTAIN CONDITIONS OF THE OFFER
 
    Notwithstanding any other provision of the Offer, Purchaser shall not be
required to accept for payment or, subject to any applicable rules and
regulations of the Commission, including Rule 14e-1(c) under the Exchange Act
(relating to Purchaser's obligation to pay for or return tendered Units promptly
after expiration or termination of the Offer), to pay for any Units tendered,
and may postpone the acceptance for payment or, subject to the restriction
referred to above, payment for any Units tendered, and may amend or terminate
the Offer if, (i) Purchaser is not satisfied prior to the Expiration Date, in
its reasonable discretion, that, upon purchase of the Units pursuant to the
Offer, it
 
                                       19
<PAGE>
and/or its nominee will have full rights to ownership as to all such Units and
that it or its nominee will become assignees of the purchased Units and a
substitute limited partner with respect to all such Units, (ii) all material
regulatory and related approvals have not been obtained or made on terms
reasonably satisfactory to Purchaser prior to the Expiration Date, or (iii) at
any time before the Expiration Date for, such Units any of the following events
shall occur or shall be deemed by Purchaser to have occurred:
 
        (A) there shall have been threatened, instituted or pending any action,
    proceeding, application or counterclaim by or before any court or
    governmental, regulatory or administrative agency, authority or tribunal,
    domestic, foreign or supranational (other than actions, proceedings,
    applications or counterclaims filed or initiated by Purchaser), which (i)
    seeks to challenge the acquisition by Purchaser of the Units, restrain,
    prohibit or delay the making or consummation of the Offer, or obtain any
    damages in connection with any of the foregoing, (ii) seeks to make the
    purchase of or payment for, some or all of the Units pursuant to the Offer
    or otherwise, illegal, (iii) seeks to impose limitations on the ability of
    Purchaser or the Partnership or any of their respective affiliates
    effectively to acquire or hold, or requiring Purchaser, the Partnership or
    any of their respective affiliates to dispose of or hold separate, any
    portion of the assets or the business of Purchaser or its affiliates or the
    Partnership or its affiliates, or impose limitations on the ability of
    Purchaser, the Partnership or any of their respective affiliates to continue
    to conduct, own or operate all or any portion of their businesses and assets
    as heretofore conducted, owned or operated, (iv) seeks to impose or may
    result in material limitations on the ability of Purchaser or any of its
    affiliates to exercise full rights of ownership of the Units purchased by
    them, (v) is reasonably likely to result in a material diminution in the
    benefits expected to be derived by Purchaser as a result of the transactions
    contemplated by the Offer or (vi) seeks to impose voting, procedural, price
    or other requirements in addition to those under California law and federal
    securities laws (each as in effect on the date of the Offer to Purchase) or
    any material condition to the Offer that is unacceptable (in its reasonable
    judgment) to Purchaser;
 
        (B) there shall have been proposed, sought, promulgated, enacted,
    entered, enforced or deemed applicable to the Offer by any domestic, foreign
    or supranational government or any governmental, administrative or
    regulatory authority or agency or by any court or tribunal, domestic,
    foreign or supranational, any statute, rule, regulation, judgment, decree,
    order or injunction that might, directly or indirectly, result in any of the
    consequences referred to in clauses (i) through (vi) of paragraph (A) above;
 
        (C) there shall have occurred (i) any general suspension of trading in,
    or limitation on prices for, securities on any national securities exchange
    or in the over-the-counter market in the United States, (ii) the declaration
    of a banking moratorium or any suspension of payments in respect of banks in
    the United States, (iii) any material adverse change (or any existing or
    threatened condition, event or development involving a prospective material
    adverse change) in United States or any other currency exchange rates or a
    suspension of, or a limitation on, the markets therefor, (iv) the
    commencement of a war, armed hostilities or other international or national
    calamity, directly or indirectly involving the United States, (v) any
    limitations (whether or not mandatory) imposed by any governmental authority
    on, or any event which might have material adverse significance with respect
    to, the nature or extension of credit or further extension of credit by
    banks or other lending institutions, (vi) any significant adverse change in
    securities or financial markets in the United States or abroad or (vii) in
    the case of any of the foregoing, a material acceleration or worsening
    thereof;
 
        (D) any change (or any development involving a prospective change) shall
    have occurred or be threatened in the business, financial condition, results
    of operations, or prospects of the Partnership which, in the reasonable
    judgment of the Purchaser, is, or may be, materially adverse to the
    Partnership, or the Purchaser shall become aware of any fact (including
    without limitation any such change or development) which, in the reasonable
    judgment of the Purchaser, has, or may have, materially adverse significance
    with respect to the Partnership; or
 
                                       20
<PAGE>
        (E) a tender offer or exchange offer for some portion or all of the
    Units shall have been commenced or publicly proposed to be made by any other
    person or entity, or it shall have been publicly disclosed or the Purchaser
    shall have learned or the Purchaser shall have cause to believe that any
    other person or entity shall have entered into a definitive agreement or an
    agreement in principle or made a proposal with respect to a tender offer or
    exchange offer for some portion or all of the Units, or the Partnership
    shall have authorized, recommended, or proposed, or shall have announced an
    intention to authorize, recommend, or propose, any other material change in
    its capitalization; or
 
        (F) any person or group shall have entered into a definitive agreement
    or agreement in principle with the Partnership with respect to a merger,
    consolidation or other business combination with the Partnership.
 
    The foregoing conditions are for the sole benefit of Purchaser and its
affiliates and may be asserted by Purchaser regardless of the circumstances
(other than any action or inaction by Parent, Purchaser or any of their
affiliates) giving rise to any such condition or may be waived by Purchaser, in
whole or in part, from time to time prior to the Expiration Date in its
reasonable discretion. The failure by Purchaser at any time to exercise any of
the foregoing rights shall not be deemed a waiver of any such right and each
such right shall be deemed an ongoing right and may be asserted at any time and
from time to time. Any reasonable determination by Purchaser concerning any of
the events described herein shall be final and binding.
 
15. CERTAIN LEGAL MATTERS
 
    The Purchaser is not aware of any license or other regulatory permit which
appears to be material to the business of the Partnership and that might be
adversely affected by the Purchaser's acquisition of Units pursuant to the
Offer, any approval or other action by any domestic or foreign governmental or
administrative agency that would be required prior to the acquisition of Units
by the Purchaser pursuant to the Offer, or any state takeover statute that is
applicable to the Offer. Should any such approval or other action be required,
or any such state takeover statute be applicable, the Purchaser will evaluate at
such time whether such approval or action will be sought or compliance with such
takeover statute will be effected. There can be no assurance that any such
approval, action, or compliance, if needed, would be obtained or effected or, if
obtained or effected, would be obtained or effected without substantial
conditions or adverse consequences. The Purchaser's obligation to purchase and
pay for the tendering Units is subject to certain conditions, including
conditions relating to the legal matters discussed herein. Section 14 above for
certain conditions to the offer.
 
    APPRAISAL RIGHTS.  Holders will not have appraisal rights as a result of the
Offer.
 
    MARGIN REQUIREMENTS.  The Units are not "margin securities" under the
regulations of the Board of Governors and the Federal Reserve System and,
accordingly, those regulations generally are not applicable to the Offer.
 
    ANTITRUST.  Under the Hart-Scott-Rodino Antitrust Improvements Act of 1976,
as amended (the "HSR Act"), and the rules and regulations that have been
promulgated thereunder by the Federal Trade Commission (the "FTC"), certain
acquisition transactions may not be consummated until certain information and
documentary material has been furnished for review by the Antitrust Division of
the Department of Justice (the "Antitrust Division") and the FTC and certain
waiting period requirements have been satisfied. The Purchaser does not
currently believe any filing is required under the HSR Act with respect to its
acquisition of Units contemplated by the Offer.
 
    In addition, the Antitrust Division and the FTC scrutinize the legality of
acquisitions, mergers, and other commercial transactions. At any time before or
after the Purchaser's purchase of Units, the Antitrust Division of the FTC could
take such action as either deems necessary or desirable in the public interest
regarding such purchase, including seeking to enjoin the purchase of Units
pursuant to the Offer, the divestiture of Units purchased thereunder or the
divestiture of substantial assets of the Partnership. Private
 
                                       21
<PAGE>
parties as well as state attorneys general may also bring legal actions under
the antitrust laws under certain circumstances. There can be no assurance that a
challenge to the Offer on antitrust grounds will not be made or, if such
challenge is made, what the result will be.
 
16. FEES AND EXPENSES
 
    Purchaser has retained State Street Bank and Trust Company to act as the
Depositary and MacKenzie Partners, Inc. as the Information Agent in connection
with the Offer. The Depositary and Information Agent will receive reasonable and
customary compensation for their services, will be reimbursed for certain
reasonable out-of-pocket expenses and will be indemnified against certain
liabilities and expenses in connection therewith, including certain liabilities
under the federal securities laws.
 
    Except as set forth above, Purchaser will not pay any fees or commissions to
any broker or dealer or other person for soliciting tenders of Units pursuant to
the Offer. Brokers, dealers, commercial banks and trust companies will be
reimbursed by Purchaser for customary mailing and handling expenses incurred by
them in forwarding the offering materials to their customers.
 
17. MISCELLANEOUS
 
    The Offer is not being made to (nor will tenders be accepted from or on
behalf of) Holders residing in any jurisdiction in which the making of the Offer
or the acceptance thereof would not be in compliance with the securities, blue
sky or other laws of the jurisdiction. However, Purchaser may, in its
discretion, take such action as it may deem necessary to make the Offer in any
jurisdiction and extend the Offer to Holders. In any jurisdiction where the
securities, blue sky or other laws require the Offer to be made by a licensed
broker or dealer, the Offer will be deemed to be made on behalf of Purchaser by
one or more registered brokers or dealers that are licensed under the laws of
the jurisdiction.
 
    Purchaser has filed with the Commission the Schedule 14D-1 pursuant to Rule
14d-1 under the Exchange Act containing certain additional information with
respect to the Offer. The Schedule and any amendments to the Schedule, including
exhibits, may be examined and copies may be obtained from the principal office
of the Commission in the manner set forth in Section 9 above (except that they
will not be available at the regional offices of the Commission).
 
    NO PERSON HAS BEEN AUTHORIZED TO GIVE ANY INFORMATION OR TO MAKE ANY
REPRESENTATION ON BEHALF OF PURCHASER NOT CONTAINED IN THIS OFFER TO PURCHASE OR
IN THE LETTER OF TRANSMITTAL AND, IF GIVEN OR MADE, THE INFORMATION OR
REPRESENTATION MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED.
 
<TABLE>
<S>                                            <C>
November 20, 1997                                                       PHARMAINVEST, L.L.C.
                                                            PHARMACEUTICAL ROYALTIES, L.L.C.
                                                     PHARMACEUTICAL ROYALTY INVESTMENTS LTD.
                                                             PHARMACEUTICAL PARTNERS, L.L.C.
</TABLE>
 
                                       22
<PAGE>
                                                                      SCHEDULE I
 
The following sets forth the name, present principal occupation or employment
and material occupation, positions, offices or employment for the past five
years of each member of the Manager of the Purchaser and the Funds. The Manager,
Pharmaceutical Partners, L.L.C. is the sole member of the Purchaser. The
business address of each such person is 70 East 55th Street, 23rd Floor, New
York, NY, 10022. Unless otherwise indicated below, each person is a citizen of
the United States.
 
    STEPHEN EVANS-FREKE, 45 years old, is a managing member of Pharmaceutical
Partners, L.L.C. ("PPLLC"), the Manager of the Purchaser. He currently serves as
Chairman and Chief Executive Officer of SUGEN, Inc., a biotechnology company
that he founded in 1991. Mr. Evans-Freke also served as non-executive Chairman
of the Board of Selectide Corporation, a drug discovery company he founded in
1990, until the sale of that company to Marion Merrell Dow in 1995. Prior to
founding SUGEN and Selectide, Mr. Evans-Freke had a 14 year career with
PaineWebber Inc. in which his last position was President of PaineWebber
Development Corporation and member of the Board of Directors of PaineWebber Inc.
Mr. Evans-Freke received a degree in Law from Trinity College, University of
Cambridge, England in 1972. Mr. Evans-Freke is a British citizen.
 
    PABLO LEGORRETA, 34 years old, is a Managing Member of PPLLC. Prior to
joining Pharmaceutical Partners in 1996, Mr. Legorreta was employed by Lazard
Freres in New York. Prior to joining Lazard Freres in 1991, Mr. Legorreta was
employed by the Lazard Houses in Paris, which he joined in 1988. Mr. Legorreta
earned a degree in Industrial Engineering from Universidad Iberoamericana in
Mexico City, Mexico, in 1985. Mr. Legorreta is a citizen of Mexico.
 
    DAVID MADDEN, 35 years old, has been a Managing Member of PPLLC since
February 1997. Mr. Madden was most recently President, Chief Executive Officer
and Director of Selectide Corporation. Mr. Madden was employed by Selectide from
1992 until the sale of the company to Marion Merrell Dow in 1995. Prior to
joining Selectide, Mr. Madden was a Vice President of PaineWebber Development
Corporation, which he joined in 1987 as an Associate. Mr. Madden received a
B.S.E.E. degree, MAGNA CUM LAUDE, from Union College in Schenectady, NY in 1984
and an M.B.A. from Columbia University in New York, NY in 1986.
 
    RORY RIGGS, 44 years old, is a Managing Member of PPLLC. He currently serves
as President of Biomatrix Corporation, which he joined in 1986. Prior to joining
Biomatrix Corporation, Mr. Riggs was interim President and Chief Executive
Officer of the RF&P Corporation from 1991 through 1995. Mr. Riggs received a
B.A. in Economics and Mathematics from Middlebury College in Middlebury, VT and
an M.B.A. from Columbia University in New York, NY.
 
                                      A-1
<PAGE>
Facsimile copies of the Letter of Transmittal, properly completed and duly
signed, will be accepted. The Letter of Transmittal and any other required
documents should be sent or delivered by each Holder or his or her broker,
dealer, commercial bank, trust company or other nominee to the Depositary or the
Purchaser, at one of the addresses set forth below:
<TABLE>
<CAPTION>
                 THE DEPOSITARY FOR THE OFFER IS:
               STATE STREET BANK AND TRUST COMPANY
                     CORPORATE REORGANIZATION
 
<S>           <C>                                     <C>
BY                                    BY MAIL:        BY
TELEPHONE:                                            FACSIMILE:
(800)                            P.O. Box 9061        (781)
426-5523                      Boston, MA 02205        794-6352
(781)
794-6388
 
                     BY OVERNIGHT OR EXPRESS MAIL
                           70 Campanelli Drive
                           Braintree, MA 02184
 
<CAPTION>
 
             THE INFORMATION AGENT FOR THE OFFER IS:
                     MACKENZIE PARTNERS, INC.
<S>           <C>                                     <C>
 
BY                                    BY MAIL:        BY
TELEPHONE:                                            FACSIMILE:
(800)                         156 Fifth Avenue        (212)
322-2885                    New York, NY 10010        929-0308
(212)
929-5500
<CAPTION>
 
                        THE PURCHASER IS:
                       PHARMAINVEST, L.L.C.
<S>           <C>                                     <C>
 
BY                                    BY MAIL:        BY
TELEPHONE:                                            FACSIMILE:
(800)                70 East 55th Street, 23rd Floor  (212)
600-1450                    New York, NY 10022        751-9324
(212)                                                 (212)
751-9300                                              759-9157
 
                                    BY E-MAIL:
                       [email protected]
</TABLE>
 
Questions and requests for assistance may be directed to the Information Agent
or Purchaser. Additional copies of this Offer to Purchase, the Letter of
Transmittal and other tender offer materials may be obtained from the
Information Agent or the Purchaser and will be furnished promptly at Purchaser's
expense. You may also contact your broker, dealer, commercial bank, trust
company or other nominee for assistance concerning the Offer.

<PAGE>
                             LETTER OF TRANSMITTAL
                                       TO
                  TENDER UNITS OF LIMITED PARTNERSHIP INTEREST
                                       IN
                        ALZA TTS RESEARCH PARTNERS, LTD.
           PURSUANT TO THE OFFER TO PURCHASE DATED NOVEMBER 20, 1997
                                       BY
                              PHARMAINVEST, L.L.C.
- --------------------------------------------------------------------------------
 
THE OFFER, PRORATION PERIOD AND WITHDRAWAL RIGHTS WILL EXPIRE AT MIDNIGHT,
EASTERN TIME, ON DECEMBER 19, 1997 (THE "EXPIRATION DATE") UNLESS SUCH OFFER IS
EXTENDED.
 
    The undersigned hereby tender(s) to PharmaInvest, L.L.C., a Delaware limited
liability company (the "Purchaser"), the number of units of limited partnership
interest ("Units") in ALZA TTS Research Partners, Ltd., a California limited
partnership (the "Partnership"), specified below, pursuant to the Purchaser's
offer to purchase up to 1,400 of the 3,200 issued and outstanding Units at a
purchase price of $12,000 per Unit, net to the seller in cash (the "Purchase
Price"), without interest thereon, upon the terms and subject to the conditions
set forth in the Offer to Purchase dated November 20, 1997 (the "Offer to
Purchase") and this Letter of Transmittal (the "Letter of Transmittal"), which,
together with the Offer to Purchase and any supplements, modifications or
amendments thereto, constitute the Offer (the "Offer"), all as more fully
described in the Offer to Purchase. HOLDERS WHO TENDER THEIR UNITS WILL NOT BE
OBLIGATED TO PAY ANY COMMISSIONS OR PARTNERSHIP TRANSFER FEES. Receipt of the
Offer to Purchase is hereby acknowledged. Capitalized terms used but not defined
herein have the respective meanings ascribed to them in the Offer to Purchase.
 
    By executing and delivering this Letter of Transmittal, a tendering Holder
irrevocably appoints designees of Purchaser as his or her attorneys-in-fact and
proxies, with full power of substitution, to the full extent of the Holder's
rights with respect to the Units (and with respect to any and all other
securities issued or issuable in respect of such Units on or after the date
hereof) tendered by the Holder. All such powers of attorney and proxies will be
considered coupled with an interest in the tendered Units and all prior powers
of attorney and proxies given by the Holder with respect to the Units will be
revoked, without further action, and no subsequent powers of attorney and
proxies may be given (and, if given, will not be deemed effective) by the
Holder. Designees of Purchaser will be empowered to exercise all voting and
other rights of the Holder with respect to such Units as they in their sole
discretion may deem proper, including, without limitation, in respect of any
annual or special meeting of the Holders, or any adjournment or postponement of
any such meeting, or in connection with any action by written consent in lieu of
any such meeting or otherwise. Purchaser reserves the absolute right to require
that, in order for Units to be validly tendered, immediately upon Purchaser's
acceptance for payment of the Units, Purchaser must be able to exercise full
voting and other rights with respect to the Units.
 
    Pursuant to such appointment as proxies and attorneys-in-fact, the Purchaser
and its designees each will have the power, among other things, (i) to seek to
transfer ownership of such Units on the books and records of the Partnership
(and execute and deliver any accompanying evidences of transfer and authenticity
any of them may deem necessary or appropriate in connection therewith,
including, without limitation, any documents or instruments required to be
executed under the Partnership Agreement or a "Transferor's (Sellers)
Application for Transfer" created by the NASD, if required), (ii) upon receipt
by the Depositary (as the tendering Holder's agent) of the Purchase Price, to be
allocated Tax Credits and tax losses and to receive any and all distributions
made by the Partnership after December 31, 1997 in respect of the Units tendered
by such Holder and accepted for payment by the Purchaser, regardless of the fact
that the record date for any such distribution may be a date prior to or after
the Expiration Date, (iii) the right to transfer or assign, in whole or from
time to time in part, to any third party, the right to purchase Units tendered
pursuant to the Offer, together with its rights under the Letter of Transmittal,
but any such transfer or assignment will not relieve the assigned party of its
obligations under the Offer or prejudice the right of tendering Holders to
receive payment for Units validly tendered and accepted for payment pursuant to
the Offer, and (iv) to execute and deliver to the Partnership, the General
Partner and/or designee (as the case may be) a change of address form
instructing the Partnership to send any and all future distributions to which
the Purchaser is entitled pursuant to the terms of the Offer in respect of
tendered Units to the address specified in such form and to endorse any check
payable to or upon the order of such Holder representing a distribution, if any,
to which the Purchaser is entitled pursuant to the terms of the Offer, in each
case on behalf of the tendering Holder. This power of attorney shall not be
affected by the subsequent mental disability of the Holder, and the Purchaser
shall not be required to post bond in any nature in connection with this power
of attorney. The Purchaser may assign such power of attorney to any person with
or without assigning the related Units with respect to which such power of
attorney was granted. If legal title to the Units is held through an IRA or
KEOGH or similar account, the Holder understands that this Letter of Transmittal
must be signed by the custodian of such IRA or KEOGH account and the Holder
hereby authorizes and directs the custodian of such IRA or KEOGH to confirm this
Letter of Transmittal.
 
    By executing this Letter of Transmittal, the undersigned represents that
either (a) the undersigned is not a plan subject to Title I of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA") or Section 4975 of
the Internal Revenue Code of 1986, as amended (the "Code"), or an entity deemed
to hold "plan assets" within the meaning of 29 C.F.R. Section2510.3-101 of any
such plan; or (b) the tender and acceptance of Units pursuant to the Offer will
not result in a non-exempt prohibited transaction under Section 406 of ERISA or
Section 4975 of the Code.
 
                          (Continued on Reverse Side)
 
<TABLE>
<CAPTION>
                                                              TOTAL
                                                              PURCHASE PRICE
           NUMBER OF     NUMBER OF(1)     PURCHASE PRICE(2)   IF ALL UNITS
           UNITS OWNED   UNITS TENDERED   PER UNIT            TENDERED
           -----------   --------------   -----------------   ---------------------
<S>        <C>           <C>              <C>                 <C>
 
           (1) If no indication is marked above, all Units held will be deemed to
           have been tendered.
           (2) Reduced by the amount of any distributions made by the Partnership
           after December 31, 1997.
</TABLE>
 
    (PLEASE INDICATE CHANGES OR CORRECTIONS TO THE ADDRESS ABOVE, IF NECESSARY.)
<PAGE>
    By executing this Letter of Transmittal, the undersigned represents that
this transfer has not been effected through an established securities market or
through a broker-dealer or matching agent which makes a market in Units or which
provides a widely available, regular and on-going opportunity to the Holder of
Units to sell or exchange their Units through a public means of obtaining or
providing information of offers to buy, sell or exchange Units.
 
    The undersigned recognizes that if proration is required pursuant to the
terms of the Offer, the Purchaser will accept for payment from among those Units
validly tendered and not properly withdrawn on or prior to the Expiration Date,
the maximum number of Units permitted pursuant to the Offer on a pro rata basis
with adjustments to avoid purchases which would violate the terms of the Offer,
based upon the number of Units validly tendered prior to the Expiration Date and
not properly withdrawn.
 
    The undersigned understands that a tender of Units to the Purchaser will
constitute a binding agreement between the undersigned and the Purchaser upon
the terms and subject to the conditions of the Offer. The undersigned recognizes
that under certain circumstances set forth in Section 2 ("Proration; Acceptance
for Payment for Units") and Section 14 ("Conditions of the Offer") of the Offer
to Purchase, the Purchaser may not be required to accept for payment any of the
Units tendered hereby. In such event, the undersigned understands that any
Letter of Transmittal for Units not accepted for payment will be destroyed by
the Purchaser. Except as stated in Section 4 ("Withdrawal Rights") of the Offer
to Purchaser, this tender is irrevocable, provided Units tendered pursuant to
the Offer may be withdrawn at any time prior to the Expiration Date. The
undersigned acknowledges that (i) upon acceptance of, and payment for, tendered
Units, the undersigned shall no longer be entitled to any benefits as a Holder.
 
<TABLE>
<S>                                                             <C>
                                                    SIGNATURE BOX--PUBLIC NOTARY
 
Please sign exactly as your name is printed on the front of     The Internal Revenue Service does not require your consent to any
this Letter of Transmittal. For joint owners, each joint        provision of this document other than the certifications required to
owner must sign. (SEE INSTRUCTION 2.) The signatory hereto      avoid backup withholding.
hereby certifies under penalties of perjury that the address    X
as printed or corrected on the front of this Letter of          --------------------------------------------------------------------
Transmittal and the Taxpayer Identification Number (i.e.,                      (Signature of Holder)          (Date)
the social security number) furnished in the blank provided     X
in this Signature Box is correct. The undersigned hereby        --------------------------------------------------------------------
represents and warrants for the benefit of the Partnership               Taxpayer Identification Number (See Instruction 4)
and the Purchaser that the Holder owns the Units tendered       X
hereby and has full power and authority to validly tender,      --------------------------------------------------------------------
sell, assign, transfer, convey and deliver the Units                          (Signature of Co-Holder)         (Date)
tendered hereby and that when the same are accepted for         (Title)
payment by the Purchaser, the Purchaser will acquire good,      --------------------------------------------------------------------
marketable and unencumbered title thereto, free and clear of    Telephone (Day) (   )       Telephone (Eve) (   )
all liens, restrictions, charges, encumbrances, conditional     --------------------------              --------------------------
sales agreements or other obligations relating to the sale      Notary Public Stamp:
or transfer thereof, and such Units will not be subject to      --------------------------------------------------------------------
any adverse claims, and that the transfer and the assignment    Authorized Signature:
contemplated herein is in compliance with all applicable        --------------------------------------------------------------------
laws and regulations and not in conflict with the
Partnership Agreement. All authority herein conferred or
agreed to be conferred shall survive the death or incapacity
of the undersigned and any obligations of the undersigned
shall be binding upon the heirs, personal representatives,
successors and assigns of the undersigned.
</TABLE>
 
                               TAX CERTIFICATIONS
 
                              SUBSTITUTE FORM W-9
                              (SEE INSTRUCTION 4)
 
The person signing this Letter of Transmittal hereby certifies the following to
the Purchaser under penalties of perjury:
 
(i) The Taxpayer Identification Number ("TIN") furnished in the space provided
for that purpose in the Signature Box of this Letter of Transmittal is the
correct TIN of the Holder; or if this box / / is checked, the Holder has applied
for a TIN. If the Holder has applied for a TIN, a TIN has not been issued to the
Holder, and either: (a) the Holder has mailed or delivered an application to
receive a TIN to the appropriate Internal Revenue Service ("IRS") Center or
Social Security Administration Office, or (b) the Holder intends to mail or
deliver an application in the near future, it is hereby understood that if the
Holder does not provide a TIN to the Purchaser within sixty (60) days 31% of all
reportable payments made to the Holder thereafter will be withheld until a TIN
is provided to the Purchaser; and
 
(ii) Unless this box / / is checked, the Holder is not subject to backup
withholding either because the Holder: (a) is exempt from backup withholding,
(b) has not been notified by the IRS that the Holder is subject to backup
withholding as a result of a failure to report all interest or dividends, or (c)
has been notified by the IRS that such Holder is no longer subject to backup
withholding.
 
Note: Place an "X" in the box in (ii) above, ONLY if you are unable to certify
that the Holder is not subject to backup withholding.
 
PLEASE CAREFULLY READ THE FOLLOWING INSTRUCTIONS FOR THIS LETTER OF TRANSMITTAL
FOR INFORMATION CALL THE INFORMATION AGENT, MACKENZIE PARTNERS, AT
(800) 322-2885
<PAGE>
                                  INSTRUCTIONS
             FORMING PART OF THE TERMS AND CONDITIONS OF THE OFFER
 
- --------------------------------------------------------------------------------
 
THE OFFER, PRORATION PERIOD AND WITHDRAWAL RIGHTS WILL EXPIRE AT MIDNIGHT,
EASTERN TIME, ON DECEMBER 19, 1997 (THE "EXPIRATION DATE") UNLESS SUCH OFFER IS
EXTENDED.
- --------------------------------------------------------------------------------
 
1. DELIVERY OF LETTER OF TRANSMITTAL.  For convenience in responding to the
  Offer, a pre-addressed, postage-paid envelope has been enclosed with the Offer
  to Purchase. HOWEVER, TO ENSURE RECEIPT OF THE LETTER OF TRANSMITTAL IT IS
  SUGGESTED THAT YOU USE OVERNIGHT COURIER DELIVERY OR, IF THE LETTER OF
  TRANSMITTAL IS TO BE DELIVERED BY UNITED STATES MAIL, THAT YOU USE CERTIFIED
  OR REGISTERED MAIL, RETURN RECEIPT REQUESTED.
 
  TENDER REQUIREMENTS.  To be effective, a duly completed and signed Letter of
  Transmittal, and any other required documents must be received by the
  Depositary at the address set forth below before the Expiration Date, unless
  extended. Letters of Transmittal which have been duly executed, but where no
  indication is marked in the "No. of Units Tendered" space, shall be deemed to
  have tendered all Units pursuant to the Offer.
 
<TABLE>
<S>                            <C>
BY MAIL, COURIER OR            State Street Bank and Trust Company
HAND DELIVERY                  70 Campanelli Drive
                               Braintree, MA 02184
 
FOR ADDITIONAL INFORMATION     (800) 426-5523
CALL:
</TABLE>
 
  UNITS IN BROKERAGE ACCOUNT.  All Units are registered in the records of the
  Partnership in the name of the tendering Holder (or Custodian for the
  tendering Holder, if a retirement account). In order to accept the Offer and
  tender Units, the Letter of Transmittal should be completed only by the
  Holder(s) listed on the front of the Letter of Transmittal and returned
  directly to the Depositary at the address listed above. Therefore, the Letter
  of Transmittal need not be submitted through a broker or brokerage firm.
 
  THE METHOD OF DELIVERY OF THE LETTER OF TRANSMITTAL AND ALL OTHER REQUIRED
  DOCUMENTS IS AT THE OPTION AND RISK OF THE TENDERING HOLDER AND DELIVERY WILL
  BE DEEMED MADE ONLY WHEN ACTUALLY RECEIVED BY THE DEPOSITARY. IN ALL CASES,
  SUFFICIENT TIME SHOULD BE ALLOWED TO ASSURE TIMELY DELIVERY.
 
2. SIGNATURE REQUIREMENTS.
 
  INDIVIDUAL AND JOINT OWNERS.  After carefully reading and completing the
  Letter of Transmittal, in order to tender Units, Holders must sign at the "X"
  in the SIGNATURE BOX of the Letter of Transmittal. The signature(s) must
  correspond exactly with the name printed (or corrected) on the front of the
  Letter of Transmittal, without any change whatsoever. If any Units are
  registered in the names of two or more joint Holders, all such Holders must
  sign the Letter of Transmittal.
 
  CUSTODIANS, TRUSTEES, CORPORATIONS AND FIDUCIARIES.  Custodian(s) and/or
  trustee(s) (if the Units are held in an IRA, KEOGH, pension or similar
  account), or executors, administrators, guardians, attorneys-in-fact, officers
  of a corporation, authorized partner of a partnership or other persons acting
  in a fiduciary or representative capacity must sign at the "X" in the
  SIGNATURE BOX and must submit proper evidence satisfactory to the Purchaser of
  their authority to so act. (See Instruction 3 herein).
 
  PUBLIC NOTARY.  All signatures on the Letter of Transmittal must be notarized
  by a Public Notary.
 
3. DOCUMENTATION REQUIREMENTS.  In addition to information required to be
  completed on the Letter of Transmittal, additional documentation may be
  required by the Purchaser under certain circumstances including, BUT NOT
  LIMITED TO THOSE LISTED BELOW. Questions on documentation should be directed
  to The Depositary at (800) 426-5523. ALL SIGNATURES MUST BE NOTARIZED (SEE
  INSTRUCTION 2).
 
<TABLE>
<S>                             <C>
DECEASED OWNER (JOINT TENANT)   --  Certified Copy of Death Certificate.
 
DECEASED OWNER (OTHERS)         --  Certified Copy of Death Certificate. (SEE ALSO
                                    EXECUTOR/ADMINISTRATOR/GUARDIAN BELOW).
</TABLE>
<PAGE>
<TABLE>
<S>                             <C>
EXECUTOR/ADMINISTRATOR/GUARDIAN --  Certified Copies of Court Appointment Documents for Executor or
                                    Administrator dated within 60 days; and
 
                                     (i) A copy of applicable provisions of the Will (Title Page,
                                        Executor(s) powers, asset distribution);
 
                                OR
 
                                    (ii) Certified copy of Estate distribution documents.
 
ATTORNEY-IN-FACT                --  Current Power of Attorney.
 
CORPORATIONS/PARTNERSHIPS       --  Certified copy of Corporate Resolution(s), (with raised
                                    corporate seal), or other evidence of authority to act.
                                    Partnerships should furnish copy of Partnership Agreement.
 
TRUST/PENSION PLANS             --  Copy of cover page of the Trust or Pension Plan, along with
                                    copy of the section(s) setting forth names and powers of
                                    Trustee(s) and any amendments to such sections or appointment
                                    of Successor Trustee(s).
</TABLE>
 
  4. TAX CERTIFICATIONS.  Holders tendering Units to the Purchaser pursuant to
  the Offer must certify correctness of the address as printed or corrected on
  the front of the Letter of Transmittal and his, her or its Taxpayer
  Identification Number ("TIN") as inserted in the Signature Box.
 
  SUBSTITUTE FORM W-9.
 
  PART (I), TAXPAYER IDENTIFICATION NUMBER -- The persons signing this Letter of
  Transmittal must provide to the Purchaser the Holder's correct TIN and certify
  its correctness as inserted in the Signature Box, under penalties of perjury.
  If a correct TIN is not provided, penalties may be imposed by the Internal
  Revenue Service ("IRS"), in addition to the Holder's being subject to Backup
  Withholding.
 
  PART (II), BACKUP WITHHOLDING -- in order to avoid 31% federal income tax
  Backup Withholding, the person signing this Letter of Transmittal must
  certify, under penalties of perjury, that such Holder is not subject to Backup
  Withholding. Certain Holders (including, among others, all Corporations and
  certain exempt non-profit organizations) are not subject to Backup
  Withholding. Backup Withholding is not an additional tax. If withholding
  results in an overpayment of taxes, a refund may be obtained from the IRS. DO
  NOT CHECK THE BOX IN THE SUBSTITUTE FORM W-9 PART (ii), UNLESS YOU HAVE BEEN
  NOTIFIED BY THE IRS THAT YOU ARE SUBJECT TO BACKUP WITHHOLDING.
 
  When Determining the TIN to Be Furnished, Please Refer to the Following NOTE
  as a Guideline:
 
  INDIVIDUAL ACCOUNTS should reflect their own TIN. JOINT ACCOUNTS should
  reflect the TIN of the person whose name appears first. TRUST ACCOUNTS should
  reflect the TIN assigned to the Trust. IRA CUSTODIAL ACCOUNTS should reflect
  the TIN of the custodian (not necessary to obtain). CUSTODIAL ACCOUNTS FOR THE
  BENEFIT OF MINORS should reflect the TIN of the minor. CORPORATIONS OR OTHER
  BUSINESS ENTITIES should reflect the TIN assigned to that entity.
 
5. VALIDITY OF LETTER OF TRANSMITTAL.  All questions as to the validity, form,
  eligibility (including time of receipt) and acceptance of a Letter of
  Transmittal will be determined by the Purchaser and such determination will be
  final and binding. The Letter of Transmittal will not be valid until any
  irregularities have been cured or waived. Neither the Purchaser nor The
  Depositary is under any duty to give notification of defects in a Letter of
  Transmittal and neither will incur liability for failure to give such
  notification.
 
6. CONDITIONAL TENDERS.  No alternative, conditional or contingent tenders will
  be accepted.
 
7. ASSIGNEE STATUS.  Assignees of Holders must provide documentation to the
  Information Agent/Depositary which demonstrates, to the satisfaction of the
  Purchaser, such person's status as an Assignee.
 
- --------------------------------------------------------------------------------
 
EACH HOLDER IS URGED TO READ CAREFULLY THE ENTIRE OFFER TO PURCHASE, THE LETTER
OF TRANSMITTAL AND RELATED DOCUMENTS BEFORE MAKING A DECISION TO TENDER.
- --------------------------------------------------------------------------------

<PAGE>
                              PHARMAINVEST, L.L.C.
 
                                                               November 20, 1997
 
                 OFFER TO PURCHASE AT $12,000 PER UNIT IN CASH
 
Dear Limited Partner of ALZA TTS Research Partners, Ltd.:
 
    PharmaInvest is offering to purchase up to 1,400 units of limited
partnership interest (the "Units") of ALZA TTS Research Partners (the
"Partnership") for $12,000 per Unit in cash (the "Purchase Price"). Pursuant to
the requirements for registered tender offers, we have detailed the terms and
conditions of the offer in the Offer to Purchase, which is enclosed with this
letter. The general partner of the Partnership will be mailing a comment on the
Offer to you in approximately 10 business days. WE URGE YOU READ THE ENCLOSED
MATERIAL CAREFULLY IN ORDER TO EVALUATE THE OFFER.
 
    PharmaInvest was formed to acquire royalty interests that derive cash flow
from the sales of biotechnology and pharmaceutical products. The principal asset
of the Partnership is a royalty on the sales of Duragesic-Registered Trademark-,
a pharmaceutical product within the scope of PharmaInvest's investment
objectives. As a result, any Units acquired in the Offer will represent one
component of a portfolio of other similar investments that PharmaInvest is now
assembling. Through diversification, PharmaInvest expects to address the risks
that may arise from holding a royalty interest in a single pharmaceutical
product.
 
    The Units were originally sold to you at $5,000 in 1983. From inception
through today, an original holder has received cash distributions of $7,143 per
Unit. The $12,000 Purchase Price would enable you to realize a substantial
return today, in lieu of receiving periodic payments over the next 8 to 9 years.
In addition, there is the potential for substantial tax savings, in that the
proceeds from tendering your Units would likely be taxed at today's federal
capital gain rate of 20%, rather than at ordinary income rates of up to 39.6%.
 
Following are some important features of the Offer:
 
- -  PREMIUM TO HISTORICAL OFFERS. Since there is no trading market in the Units,
    the price at which Units are bought and sold varies greatly depending on the
    venue in which buyers and sellers are matched. On various partnership
    matching services of which the Purchaser is aware, approximately 15 Units
    have been auctioned to the highest bidder over the last 12 months. According
    to Partnership Spectrum, in this venue Units have sold for a weighted
    average price of $8,889 over the last year, with the highest price of which
    PharmaInvest is aware having been $10,625 (after commissions and the
    anticipated distribution of $700 that will be made to Holders in December).
    In addition, there have been a number of unregistered offers made directly
    to Holders, the most recent of which PharmaInvest is aware was priced at
    $6,000 per Unit ($4,600 after adjusting for distributions made or expected
    to be made prior to the closing of the Offer).
 
- -  POTENTIAL TAX BENEFIT, ENHANCED BY CHANGE IN CAPITAL GAIN RATES TO 20%. Each
    Holder is generally taxable on his or her allocable share of Partnership
    profits, which are ordinary income. Ordinary income is taxed to individuals
    at rates of up to 39.6% at the federal level. The gain resulting from the
    sale of a Unit generally should be taxed to Holders at capital gain rates
    (currently 20% for most individuals disposing of capital assets held more
    than 18 months). A Holder who has been a limited partner since the original
    offering will generally have no basis in the Units. As a result, all or
    substantially all of the Purchase Price should be taxable as capital gain.
    The Purchaser is not expressing an opinion as to the tax consequences of
    tendering Units. Holders are strongly advised to consult their tax advisors
    with respect to the tax consequences of accepting the Offer.
<PAGE>
    The following example illustrates the potential federal income tax
consequences to Holders for whom the Units are capital assets that have no
remaining basis and have been held for more than 18 months. Note that the
example does not reflect the impact, if any, of state and local taxes on the
disposition or retention of the Units.
 
<TABLE>
<S>                                                                  <C>
Accepting the Offer:
Purchase Price.....................................................  $  12,000
Less: federal capital gains tax (20%)..............................     (2,400)
                                                                     ---------
Net proceeds.......................................................  $   9,600
 
Retaining your Units:
Distributions for the preceding 12 months..........................  $   2,418
Less: federal ordinary income tax (39.6%)..........................       (957)
                                                                     ---------
Net distributions..................................................  $   1,461
 
Net proceeds as a multiple of last 12 months distributions
  (net of federal taxes):..........................................      6.5 x
</TABLE>
 
    AS SHOWN ABOVE, BASED ON THE LAST 12 MONTHS AFTER-TAX DISTRIBUTIONS OF
$1,461, A HOLDER WHO RETAINS HIS/HER UNITS WOULD HAVE TO HOLD THE UNITS FOR AN
ADDITIONAL 6 1/2 YEARS TO REALIZE THE $9,600 OF AFTER-TAX PROCEEDS RECEIVED BY
ACCEPTING THE OFFER.
 
- -  SIMPLIFIED TAX RETURNS. The Offer may be attractive to certain Holders who
    wish in the future to avoid the expenses, delays and complications of filing
    complex income tax returns resulting from Form K-1s necessitated by
    ownership of Units.
 
- -  LIQUIDITY OPPORTUNITY. The Offer provides each Holder the opportunity to
    liquidate his or her investment in the Partnership without transfer fees and
    transaction costs generally incurred in secondary market sales. Although
    there are limited resale mechanisms available to Holders through partnership
    matching services, there is no formal trading market for the Units.
 
- -  VALUE DEPENDENT ON ONE PRODUCT. The bulk of the Partnership's value is based
    on the right to receive royalties on the sales of Duragesic. While the sales
    of Duragesic have grown over the last several years, there can be no
    assurance that they will continue to do so. ALZA and its marketing partner
    for Duragesic, Jannsen Pharmaceutica, are developing E-transfentanyl, a
    product that may be competitive with Duragesic. The Offer enables a Holder
    the opportunity to eliminate uncertainty with respect to future sales of
    Duragesic.
 
    Please review the enclosed Offer to Purchase carefully. As the Offer is
available for a limited period of time, we urge you to tender your Units
promptly by completing and signing page 2 of the Letter of Transmittal and
returning the Letter of Transmittal in the enclosed postage-paid envelope to the
Depositary. The Offer will expire at 12:00 midnight, New York City time,
December 19, 1997.
 
    If you have any questions or need assistance, please call our information
agent, MacKenzie Partners, Inc., at (800) 322-2885.
 
                                          Sincerely,
 
                                          PharmaInvest, L.L.C.
 
                                       2


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